TIZIANA LIFE SCIENCES PLC, a company incorporated and registered in England and Wales with company number 03508592 whose registered office is at 3^rd Floor 11-12 St. James’s Square, London SW1Y 4LB (“Topco”); and

ACCUSTEM SCIENCES LIMITED, a company incorporated and registered in England and Wales with company number 12647178 whose registered office is at 9^th Floor, 107 Cheapside, London EC2V 6DN (“Newco”).

Topco has announced its intention to effect the Demerger pursuant to which Newco will become the new holding company for the Demerged Business by virtue of its ownership of the Company and intends to seek admission of the Newco Shares to listing on the Official List and to trading on the Main Market of the London Stock Exchange.

Topco and Newco are party to a Demerger Agreement governing the implementation of the Demerger.

The parties wish to record certain additional terms upon which are intended to be encapsulated in the Demerger.

INTERPRETATION

In this agreement, unless the context otherwise requires:

In this agreement, unless the context otherwise requires:

references to “this agreement” shall include the Background and Schedules to it, which form part of this agreement, and references to clauses, the Background and Schedules are to clauses of and the Background and Schedules to this agreement;

clause, Schedule and paragraph headings shall not affect the interpretation of this agreement;

references to clauses and Schedules are to the clauses of, and Schedules to, this agreement and references to paragraphs are to paragraphs of the relevant Schedule;

the Schedules form part of this agreement and shall have effect as if set out in full in the body of this agreement. Any reference to this agreement includes the Schedules;

a reference to a “company” shall include any company, corporation or other body corporate, wherever and however incorporated or established;

a reference to a “holding company” or a “subsidiary” means a holding company or a subsidiary (as the case may be) as defined in section 1159 of the Companies Act 2006;

a reference to a statute, statutory provision or subordinate legislation is a reference to it as it is in force from time to time and includes any statute, statutory provision or subordinate legislation which it amends or re-enacts and subordinate legislation for the time being in force made under it;

a reference to “writing” or “written” includes email;

any words following the terms “including”, “include”, “in particular”, “for example” or any similar expression shall be construed as illustrative and shall not limit the sense of the words, description, definition, phrase or term preceding those terms. Where the context permits, “other” and “otherwise” are illustrative and shall not limit the sense of the words preceding them; and

references to a document in “agreed form” are to that document in the form agreed by the parties or on their behalf and initialled by them or on their behalf for identification.

ACCRUED RIGHTS OF CERTAIN PERSONS

The Circular identified that certain holders of options and warrants, the exercise of which would result in the issue of additional Topco Shares and suggested that appropriate proposals would be extended to such persons.

Newco shall procure that:

an additional 4,763,995 Newco Shares are issued to Gabriele Cerrone to reflect a realisation bonus accrued in Topco and in respect of which Mr Cerrone is unconditionally entitled through the issue of 4,763,995 Topco Shares (but for constraints on timing of delivery under Note 11 to Rule 9 of the UK Takeover Code);

an additional 397,347 Newco Shares are issued to Panetta Partners Limited to reflect a convertible loan note outstanding from Topco and in respect of which Panetta Partners Limited is entitled to exercise its conversion rights to convert the loan note and accrued interest and the exercise of associated warrants into397,347 Topco Shares (but for constraints on timing of exercise under Note 11 to Rule 9 of the UK Takeover Code);

an additional 1,830,775 Accustem Shares to Gabriele Cerrone credited as fully paid in respect of share options which Gabriele Cerrone would have exercised (and has undertaken to exercise) but for the constraints imposed by Note 11 to Rule 9 of the UK Takeover Code;

an additional 2,589,137 Accustem Shares to Gabriele Cerrone credited as fully paid in respect of a convertible loan note in respect of which Gabriele Cerrone would have exercised underlying conversion rights (and has undertaken to exercise the same) but for the constraints imposed by Note 11 to Rule 9 of the UK Takeover Code; and

to the extent that such shares were not entered in the register of members of Tiziana prior to the record date for the Demerger, the number of Newco Shares listed on the Schedule be issued to the persons listed in the Schedule credited as fully paid to reflect the exercise of certain holdings of options and warrants.

The allotment and issue by Newco of the Newco Shares pursuant to clause 2.2 (a) to (d) shall be satisfied by Topco paying to Newco the sum equal to 1.58 pence per NewCo Share, being the aggregate nominal value of the additional Newco Shares and a total payment of £151,383.

THE PLACING

FURTHER ASSURANCE

ASSIGNMENT

This agreement is personal to the parties and neither party shall assign, transfer, mortgage, charge, declare a trust of, or deal in any other manner with any of its rights and obligations under this agreement without the prior written consent of the other party.

Subject to clause 4.1, this agreement shall be binding on and shall enure to the benefit of the parties to this agreement and their respective successors and permitted assigns.

ENTIRE AGREEMENT

VARIATION AND WAIVER

No variation of this agreement shall be effective unless it is in writing and signed by the parties (or their authorised representatives).

A failure or delay by any person to exercise any right or remedy provided under this agreement or by law shall not constitute a waiver of that or any other right or remedy, nor shall it prevent or restrict the further exercise of that or any other right or remedy. No single or partial exercise of any right or remedy provided under this agreement or by law shall prevent or restrict the further exercise of that or any other right or remedy.

Except as expressly provided otherwise in this agreement, the rights and remedies provided under this agreement are in addition to, and not exclusive of, any rights or remedies provided by law.

COSTS

NOTICE

19.1     A notice given to a party under or in connection with this agreement:

shall be in writing and in English;

shall be sent to the relevant party for the attention of the contact and to the address email address specified in clause 8.2 (or such other address, email address or person as that party may notify to the other in accordance with the provisions of this clause 8); and

shall be:

delivered by hand;

sent by email;

sent by pre-paid first-class post or another next working day delivery service providing proof of delivery; and

unless proved otherwise is deemed received as set out in clause 8.4.

The addresses, email addresses, and named contacts for service of notice are:

Topco

address:             3^rd Floor 11-12 St James’s Square

SW1Y 4LB

for the attention of: [REDACTED]

email address: [REDACTED]

Newco

address:             9^th Floor, 107 Cheapside

EC2V 6DN

for the attention of: [REDACTED]

email address: [REDACTED]

A party may change its details for service of notices as specified in clause 8.2 by giving notice to the other party, provided that in the case of change to the party’s postal address the new address is an address in the UK. Any change notified pursuant to this clause shall take effect at 9.00 a.m. on the later of:

the date (if any) specified in the notice as the effective date for the change; and

five Business Days after deemed receipt of the notice of change.

Delivery of a notice is deemed to have taken effect (provided that all other requirements in this clause have been satisfied):

if delivered by hand, on signature of a delivery receipt or at the time the notice is left at the address;

if sent by email, at the time of transmission;

in the case of pre-paid first-class post or another next working day delivery service delivery to an address in the UK, at 9.00 am on the second Business Day after posting or at the time recorded by the delivery service;

if deemed receipt under the previous paragraphs of this clause 8.4 would occur outside business hours (meaning 9.00 am to 5.30 pm Monday to Friday on a day that is not a public holiday in the place of receipt), at 9.00 am on the day when business next starts in the place of receipt. For the purposes of this clause, all references to time are to local time in the place of deemed receipt.

This clause 8 does not apply to the service of any proceedings or other documents in any legal action or proceedings or, where applicable, any arbitration or other method of dispute resolution.

SEVERANCE

AGREEMENT SURVIVES THE DEMERGER EFFECTIVE DATE

THIRD PARTY RIGHTS

This agreement does not give rise to any rights under the Contracts (Rights of Third Parties) Act 1999 to enforce any term of this agreement.

The rights of the parties to rescind or vary this agreement are not subject to the consent of any other person.

COUNTERPARTS

GOVERNING LAW AND JURISDICTION

This agreement and any dispute or claim (including non-contractual disputes or claims) arising out of or in connection with it or its subject matter or formation shall be governed by and construed in accordance with the laws of England and Wales.

Each party irrevocably agrees that the courts of England and Wales shall have exclusive jurisdiction to settle any dispute or claim (including non-contractual disputes or claims) that arises out of or in connection with this agreement or its subject matter or formation.