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<?xml version="1.0" encoding="windows-1252"?> |
<!-- Generated by DFIN XBRL Instance Document - http://www.dfinsolutions.com/ - Version R3.0 - on 29-April-2023 [12:20:42] {AM} --> |
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| <roleRef xlink:type="simple" xlink:href="https://xbrl.sec.gov/ecd/2022q4/ecd-2022q4.xsd#PvpAdjustmentsOnly" roleURI="http://xbrl.sec.gov/ecd/role/PvpAdjustmentsOnly"/> |
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| <arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/> |
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| | <loc xlink:type="locator" xlink:href="biib-20221231.xsd#biib_Mr.viehbacherMember" xlink:label="Mr.viehbacherMember"/> |
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| | <loc xlink:type="locator" xlink:href="biib-20221231.xsd#biib_PriorFiscalYearendForAwardsThatVestedDuringTheYearMember" xlink:label="PriorFiscalYearendForAwardsThatVestedDuringTheYearMember"/> |
| | <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="AllAdjToCompMember" xlink:to="PriorFiscalYearendForAwardsThatVestedDuringTheYearMember" order="105"/> |
| | <loc xlink:type="locator" xlink:href="biib-20221231.xsd#biib_TotalEquityAwardAdjustmentsMember" xlink:label="TotalEquityAwardAdjustmentsMember"/> |
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| | <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="AllAdjToCompMember" xlink:to="YearoveryearChangeInFairValueOfEquityAwardsMember" order="107"/> |
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