SEC Info  
    Home      Search      My Interests      Help      Sign In      Please Sign In

Iovance Biotherapeutics, Inc. – ‘10-Q’ for 6/30/20 – ‘EX-101.CAL’

On:  Thursday, 8/6/20, at 5:16pm ET   ·   For:  6/30/20   ·   Accession #:  1104659-20-91526   ·   File #:  1-36860

Previous ‘10-Q’:  ‘10-Q’ on 5/5/20 for 3/31/20   ·   Next:  ‘10-Q’ on 11/5/20 for 9/30/20   ·   Latest:  ‘10-Q’ on 11/7/23 for 9/30/23   ·   9 References:   

Find Words in Filings emoji
 
  in    Show  and   Hints

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 8/06/20  Iovance Biotherapeutics, Inc.     10-Q        6/30/20   63:7.7M                                   Toppan Merrill/FA

Quarterly Report   —   Form 10-Q
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-Q        Quarterly Report                                    HTML   1.27M 
 2: EX-10.3     Material Contract                                   HTML     38K 
 3: EX-10.4     Material Contract                                   HTML     51K 
 4: EX-31.1     Certification -- §302 - SOA'02                      HTML     23K 
 5: EX-31.2     Certification -- §302 - SOA'02                      HTML     23K 
 6: EX-32.1     Certification -- §906 - SOA'02                      HTML     20K 
 7: EX-32.2     Certification -- §906 - SOA'02                      HTML     20K 
14: R1          Document And Entity Information                     HTML     71K 
15: R2          Condensed Consolidated Balance Sheets               HTML     90K 
16: R3          Condensed Consolidated Balance Sheets               HTML     40K 
                (Parenthetical)                                                  
17: R4          Condensed Consolidated Statements of Operations     HTML     40K 
18: R5          Condensed Consolidated Statements of Comprehensive  HTML     29K 
                Loss                                                             
19: R6          Condensed Consolidated Statements of Stockholders'  HTML     80K 
                Equity                                                           
20: R7          Condensed Consolidated Statements of Cash Flows     HTML     84K 
21: R8          General Organization and Business                   HTML     29K 
22: R9          Summary of Significant Accounting Policies          HTML    143K 
23: R10         Cash Equivalents and Short-Term Investments         HTML    108K 
24: R11         Balance Sheet Components                            HTML     37K 
25: R12         Stockholders' Equity                                HTML     30K 
26: R13         Stock Based Compensation                            HTML     71K 
27: R14         Licenses and Agreements                             HTML     38K 
28: R15         Legal Proceedings                                   HTML     37K 
29: R16         Leases                                              HTML    141K 
30: R17         Related Party Transactions                          HTML     22K 
31: R18         Subsequent Event                                    HTML     21K 
32: R19         Summary of Significant Accounting Policies          HTML    173K 
                (Policies)                                                       
33: R20         Summary of Significant Accounting Policies          HTML    127K 
                (Tables)                                                         
34: R21         Cash Equivalents and Short-Term Investments         HTML    108K 
                (Tables)                                                         
35: R22         Balance Sheet Components (Tables)                   HTML     36K 
36: R23         Stock Based Compensation (Tables)                   HTML     64K 
37: R24         Leases (Tables)                                     HTML    129K 
38: R25         General Organization and Business (Details)         HTML     44K 
39: R26         SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES - Cash,  HTML     38K 
                Cash equivalents and Restricted Cash (Details)                   
40: R27         SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES - Loss   HTML     28K 
                per share (Details)                                              
41: R28         SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES - Fair   HTML     25K 
                value (Details)                                                  
42: R29         SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES -        HTML     23K 
                Stock-based compensation expense (Details)                       
43: R30         SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES -        HTML     23K 
                Stock-based compensation by instrument (Details)                 
44: R31         Cash Equivalents and Short-Term Investments         HTML     26K 
                (Details)                                                        
45: R32         Cash Equivalents and Short-Term Investments -       HTML     23K 
                Short-term investments (Details)                                 
46: R33         CASH EQUIVALENTS AND SHORT-TERM INVESTMENTS - Cost  HTML     33K 
                and fair value (Details)                                         
47: R34         Balance Sheet Components (Details)                  HTML     34K 
48: R35         Stockholders' Equity (Details)                      HTML     90K 
49: R36         STOCK BASED COMPENSATION - Stock Options (Details)  HTML     59K 
50: R37         STOCK BASED COMPENSATION - Assumptions (Details)    HTML     31K 
51: R38         STOCK BASED COMPENSATION - Additional information   HTML    104K 
                (Details)                                                        
52: R39         Licenses and Agreements (Details)                   HTML     69K 
53: R40         Legal Proceedings (Details)                         HTML     51K 
54: R41         LEASES - Company's right-of-use asset and lease     HTML     28K 
                liabilities (Details)                                            
55: R42         LEASES - components of lease expenses (Details)     HTML     42K 
56: R43         LEASES - maturities of the Company's operating      HTML     45K 
                lease liabilities (Details)                                      
57: R44         LEASES - Additional information (Details)           HTML    142K 
58: R45         RELATED PARTY TRANSACTIONS - Additional             HTML     35K 
                information (Details)                                            
59: R46         Subsequent Event (Details)                          HTML     23K 
61: XML         IDEA XML File -- Filing Summary                      XML    106K 
13: XML         XBRL Instance -- iova-20200630x10q_htm               XML   1.90M 
60: EXCEL       IDEA Workbook of Financial Reports                  XLSX     88K 
 9: EX-101.CAL  XBRL Calculations -- iova-20200630_cal               XML    113K 
10: EX-101.DEF  XBRL Definitions -- iova-20200630_def                XML    491K 
11: EX-101.LAB  XBRL Labels -- iova-20200630_lab                     XML    881K 
12: EX-101.PRE  XBRL Presentations -- iova-20200630_pre              XML    744K 
 8: EX-101.SCH  XBRL Schema -- iova-20200630                         XSD    133K 
62: JSON        XBRL Instance as JSON Data -- MetaLinks              254±   388K 
63: ZIP         XBRL Zipped Folder -- 0001104659-20-091526-xbrl      Zip    351K 


‘EX-101.CAL’   —   XBRL Calculations — iova-20200630_cal


This Exhibit is an XBRL XML File.


                                                                                                                                                                                
<?xml version="1.0" encoding="windows-1252"?>
<!-- XBRL document created with Toppan Merrill Bridge 9.6.7401.38943 -->
<!-- Based on XBRL 2.1 -->
<!-- Created on: 8/6/2020 5:18:34 PM -->
<!-- Modified on: 8/6/2020 5:18:34 PM -->
<linkbase xmlns="http://www.xbrl.org/2003/linkbase" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xlink="http://www.w3.org/1999/xlink" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
<roleRef xlink:type="simple" xlink:href="iova-20200630.xsd#StatementCondensedConsolidatedBalanceSheets" roleURI="http://lbio.com/role/StatementCondensedConsolidatedBalanceSheets"/>
<roleRef xlink:type="simple" xlink:href="iova-20200630.xsd#StatementCondensedConsolidatedStatementsOfOperations" roleURI="http://lbio.com/role/StatementCondensedConsolidatedStatementsOfOperations"/>
<roleRef xlink:type="simple" xlink:href="iova-20200630.xsd#StatementCondensedConsolidatedStatementsOfComprehensiveLoss" roleURI="http://lbio.com/role/StatementCondensedConsolidatedStatementsOfComprehensiveLoss"/>
<roleRef xlink:type="simple" xlink:href="iova-20200630.xsd#StatementCondensedConsolidatedStatementsOfCashFlows" roleURI="http://lbio.com/role/StatementCondensedConsolidatedStatementsOfCashFlows"/>
<roleRef xlink:type="simple" xlink:href="iova-20200630.xsd#DisclosureSummaryOfSignificantAccountingPoliciesCashCashEquivalentsAndRestrictedCashDetails" roleURI="http://lbio.com/role/DisclosureSummaryOfSignificantAccountingPoliciesCashCashEquivalentsAndRestrictedCashDetails"/>
<roleRef xlink:type="simple" xlink:href="iova-20200630.xsd#DisclosureBalanceSheetComponentsDetails" roleURI="http://lbio.com/role/DisclosureBalanceSheetComponentsDetails"/>
<roleRef xlink:type="simple" xlink:href="iova-20200630.xsd#DisclosureLeasesCompanySRightOfUseAssetAndLeaseLiabilitiesDetails" roleURI="http://lbio.com/role/DisclosureLeasesCompanySRightOfUseAssetAndLeaseLiabilitiesDetails"/>
<roleRef xlink:type="simple" xlink:href="iova-20200630.xsd#DisclosureLeasesComponentsOfLeaseExpensesDetails" roleURI="http://lbio.com/role/DisclosureLeasesComponentsOfLeaseExpensesDetails"/>
<roleRef xlink:type="simple" xlink:href="iova-20200630.xsd#DisclosureLeasesMaturitiesOfCompanySOperatingLeaseLiabilitiesDetails" roleURI="http://lbio.com/role/DisclosureLeasesMaturitiesOfCompanySOperatingLeaseLiabilitiesDetails"/>
<roleRef xlink:type="simple" xlink:href="iova-20200630.xsd#DisclosureLeasesMaturitiesOfCompanySOperatingLeaseLiabilitiesDetailsCalc2" roleURI="http://lbio.com/role/DisclosureLeasesMaturitiesOfCompanySOperatingLeaseLiabilitiesDetailsCalc2"/>
<calculationLink xlink:role="http://lbio.com/role/StatementCondensedConsolidatedBalanceSheets" xlink:type="extended" xlink:title="00100 - Statement - Condensed Consolidated Balance Sheets">
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsCurrent" xlink:label="us-gaap_AssetsCurrent_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets" xlink:to="us-gaap_AssetsCurrent_637323311126623354" order="1" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="us-gaap_CashAndCashEquivalentsAtCarryingValue_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_AssetsCurrent_637323311126623354" xlink:to="us-gaap_CashAndCashEquivalentsAtCarryingValue_637323311126623354" order="1" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortTermInvestments" xlink:label="us-gaap_ShortTermInvestments_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_AssetsCurrent_637323311126623354" xlink:to="us-gaap_ShortTermInvestments_637323311126623354" order="2" use="optional" weight="1" priority="2"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:label="us-gaap_PrepaidExpenseAndOtherAssetsCurrent_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_AssetsCurrent_637323311126623354" xlink:to="us-gaap_PrepaidExpenseAndOtherAssetsCurrent_637323311126623354" order="3" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset" xlink:label="us-gaap_OperatingLeaseRightOfUseAsset_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets" xlink:to="us-gaap_OperatingLeaseRightOfUseAsset_637323311126623354" order="2" use="optional" weight="1" priority="2"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedCash" xlink:label="us-gaap_RestrictedCash_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets" xlink:to="us-gaap_RestrictedCash_637323311126623354" order="3" use="optional" weight="1" priority="2"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="us-gaap_PropertyPlantAndEquipmentNet_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets" xlink:to="us-gaap_PropertyPlantAndEquipmentNet_637323311126623354" order="4" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherAssetsNoncurrent" xlink:label="us-gaap_OtherAssetsNoncurrent_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets" xlink:to="us-gaap_OtherAssetsNoncurrent_637323311126623354" order="5" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="us-gaap_StockholdersEquity_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity" xlink:to="us-gaap_StockholdersEquity_637323311126623354" order="1" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockValue" xlink:label="us-gaap_PreferredStockValue_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_StockholdersEquity_637323311126623354" xlink:to="us-gaap_PreferredStockValue_637323311126623354" order="1" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockValue" xlink:label="us-gaap_CommonStockValue_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_StockholdersEquity_637323311126623354" xlink:to="us-gaap_CommonStockValue_637323311126623354" order="2" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_StockholdersEquity_637323311126623354" xlink:to="us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_637323311126623354" order="3" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="us-gaap_AdditionalPaidInCapital_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_StockholdersEquity_637323311126623354" xlink:to="us-gaap_AdditionalPaidInCapital_637323311126623354" order="4" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="us-gaap_RetainedEarningsAccumulatedDeficit_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_StockholdersEquity_637323311126623354" xlink:to="us-gaap_RetainedEarningsAccumulatedDeficit_637323311126623354" order="5" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Liabilities" xlink:label="us-gaap_Liabilities_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity" xlink:to="us-gaap_Liabilities_637323311126623354" order="2" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesCurrent" xlink:label="us-gaap_LiabilitiesCurrent_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_Liabilities_637323311126623354" xlink:to="us-gaap_LiabilitiesCurrent_637323311126623354" order="1" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountsPayableCurrent" xlink:label="us-gaap_AccountsPayableCurrent_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent_637323311126623354" xlink:to="us-gaap_AccountsPayableCurrent_637323311126623354" order="1" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent" xlink:label="us-gaap_AccruedLiabilitiesCurrent_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent_637323311126623354" xlink:to="us-gaap_AccruedLiabilitiesCurrent_637323311126623354" order="2" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent" xlink:label="us-gaap_OperatingLeaseLiabilityCurrent_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent_637323311126623354" xlink:to="us-gaap_OperatingLeaseLiabilityCurrent_637323311126623354" order="3" use="optional" weight="1" priority="2"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesNoncurrent" xlink:label="us-gaap_LiabilitiesNoncurrent_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_Liabilities_637323311126623354" xlink:to="us-gaap_LiabilitiesNoncurrent_637323311126623354" order="2" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent" xlink:label="us-gaap_OtherLiabilitiesNoncurrent_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesNoncurrent_637323311126623354" xlink:to="us-gaap_OtherLiabilitiesNoncurrent_637323311126623354" order="1" use="optional" weight="1" priority="2"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent" xlink:label="us-gaap_OperatingLeaseLiabilityNoncurrent_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesNoncurrent_637323311126623354" xlink:to="us-gaap_OperatingLeaseLiabilityNoncurrent_637323311126623354" order="2" use="optional" weight="1" priority="2"/>
</calculationLink>
<calculationLink xlink:role="http://lbio.com/role/StatementCondensedConsolidatedStatementsOfOperations" xlink:type="extended" xlink:title="00200 - Statement - Condensed Consolidated Statements of Operations">
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="us-gaap_NetIncomeLoss_636970545544882622"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="us-gaap_OperatingIncomeLoss_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetIncomeLoss_636970545544882622" xlink:to="us-gaap_OperatingIncomeLoss_637323311126623354" order="1" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingExpenses" xlink:label="us-gaap_OperatingExpenses_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_OperatingIncomeLoss_637323311126623354" xlink:to="us-gaap_OperatingExpenses_637323311126623354" order="1" use="optional" weight="-1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="us-gaap_ResearchAndDevelopmentExpense_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_OperatingExpenses_637323311126623354" xlink:to="us-gaap_ResearchAndDevelopmentExpense_637323311126623354" order="1" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GeneralAndAdministrativeExpense" xlink:label="us-gaap_GeneralAndAdministrativeExpense_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_OperatingExpenses_637323311126623354" xlink:to="us-gaap_GeneralAndAdministrativeExpense_637323311126623354" order="2" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InvestmentIncomeInterest" xlink:label="us-gaap_InvestmentIncomeInterest_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetIncomeLoss_636970545544882622" xlink:to="us-gaap_InvestmentIncomeInterest_637323311126623354" order="2" use="optional" weight="1"/>
</calculationLink>
<calculationLink xlink:role="http://lbio.com/role/StatementCondensedConsolidatedStatementsOfComprehensiveLoss" xlink:type="extended" xlink:title="00300 - Statement - Condensed Consolidated Statements of Comprehensive Loss">
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="us-gaap_NetIncomeLoss_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax" xlink:to="us-gaap_NetIncomeLoss_637323311126623354" order="1" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax" xlink:to="us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_637323311126623354" order="2" use="optional" weight="1"/>
</calculationLink>
<calculationLink xlink:role="http://lbio.com/role/StatementCondensedConsolidatedStatementsOfCashFlows" xlink:type="extended" xlink:title="00500 - Statement - Condensed Consolidated Statements of Cash Flows">
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect" xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="us-gaap_NetCashProvidedByUsedInOperatingActivities_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect" xlink:to="us-gaap_NetCashProvidedByUsedInOperatingActivities_637323311126623354" order="1" use="optional" weight="1" priority="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="us-gaap_NetIncomeLoss_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_637323311126623354" xlink:to="us-gaap_NetIncomeLoss_637323311126623354" order="1" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="us-gaap_DepreciationDepletionAndAmortization_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_637323311126623354" xlink:to="us-gaap_DepreciationDepletionAndAmortization_637323311126623354" order="2" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="iova-20200630.xsd#iova_NonCashLeaseExpense" xlink:label="iova_NonCashLeaseExpense_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_637323311126623354" xlink:to="iova_NonCashLeaseExpense_637323311126623354" order="3" use="optional" weight="1" priority="2"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainLossRelatedToLitigationSettlement" xlink:label="us-gaap_GainLossRelatedToLitigationSettlement_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_637323311126623354" xlink:to="us-gaap_GainLossRelatedToLitigationSettlement_637323311126623354" order="4" use="optional" weight="-1" priority="3"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AmortizationOfDebtDiscountPremium" xlink:label="us-gaap_AmortizationOfDebtDiscountPremium_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_637323311126623354" xlink:to="us-gaap_AmortizationOfDebtDiscountPremium_637323311126623354" order="5" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:label="us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_637323311126623354" xlink:to="us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_637323311126623354" order="6" use="optional" weight="-1"/>
<loc xlink:type="locator" xlink:href="iova-20200630.xsd#iova_IncreaseDecreaseInOperatingLeaseRightOfUseAsset" xlink:label="iova_IncreaseDecreaseInOperatingLeaseRightOfUseAsset_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_637323311126623354" xlink:to="iova_IncreaseDecreaseInOperatingLeaseRightOfUseAsset_637323311126623354" order="7" use="optional" weight="1" priority="2"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable" xlink:label="us-gaap_IncreaseDecreaseInAccountsPayable_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_637323311126623354" xlink:to="us-gaap_IncreaseDecreaseInAccountsPayable_637323311126623354" order="8" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities" xlink:label="us-gaap_IncreaseDecreaseInAccruedLiabilities_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_637323311126623354" xlink:to="us-gaap_IncreaseDecreaseInAccruedLiabilities_637323311126623354" order="9" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="us-gaap_ShareBasedCompensation_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_637323311126623354" xlink:to="us-gaap_ShareBasedCompensation_637323311126623354" order="10" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="us-gaap_NetCashProvidedByUsedInInvestingActivities_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect" xlink:to="us-gaap_NetCashProvidedByUsedInInvestingActivities_637323311126623354" order="2" use="optional" weight="1" priority="2"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities" xlink:label="us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInInvestingActivities_637323311126623354" xlink:to="us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities_637323311126623354" order="1" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecurities" xlink:label="us-gaap_PaymentsToAcquireAvailableForSaleSecurities_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInInvestingActivities_637323311126623354" xlink:to="us-gaap_PaymentsToAcquireAvailableForSaleSecurities_637323311126623354" order="2" use="optional" weight="-1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" xlink:label="us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInInvestingActivities_637323311126623354" xlink:to="us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_637323311126623354" order="3" use="optional" weight="-1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="us-gaap_NetCashProvidedByUsedInFinancingActivities_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect" xlink:to="us-gaap_NetCashProvidedByUsedInFinancingActivities_637323311126623354" order="3" use="optional" weight="1" priority="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation" xlink:label="us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInFinancingActivities_637323311126623354" xlink:to="us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_637323311126623354" order="1" use="optional" weight="-1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromStockOptionsExercised" xlink:label="us-gaap_ProceedsFromStockOptionsExercised_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInFinancingActivities_637323311126623354" xlink:to="us-gaap_ProceedsFromStockOptionsExercised_637323311126623354" order="2" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock" xlink:label="us-gaap_ProceedsFromIssuanceOfCommonStock_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInFinancingActivities_637323311126623354" xlink:to="us-gaap_ProceedsFromIssuanceOfCommonStock_637323311126623354" order="3" use="optional" weight="1" priority="2"/>
</calculationLink>
<calculationLink xlink:role="http://lbio.com/role/DisclosureSummaryOfSignificantAccountingPoliciesCashCashEquivalentsAndRestrictedCashDetails" xlink:type="extended" xlink:title="40201 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES - Cash, Cash equivalents and Restricted Cash (Details)">
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="us-gaap_CashAndCashEquivalentsAtCarryingValue_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:to="us-gaap_CashAndCashEquivalentsAtCarryingValue_637323311126623354" order="1" use="optional" weight="1" priority="2"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedCash" xlink:label="us-gaap_RestrictedCash_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:to="us-gaap_RestrictedCash_637323311126623354" order="2" use="optional" weight="1" priority="2"/>
</calculationLink>
<calculationLink xlink:role="http://lbio.com/role/DisclosureBalanceSheetComponentsDetails" xlink:type="extended" xlink:title="40401 - Disclosure - BALANCE SHEET COMPONENTS (Details)">
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent"/>
<loc xlink:type="locator" xlink:href="iova-20200630.xsd#iova_ClinicalRelatedExpensesCurrent" xlink:label="iova_ClinicalRelatedExpensesCurrent_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent" xlink:to="iova_ClinicalRelatedExpensesCurrent_637323311126623354" order="1" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccruedEmployeeBenefitsCurrent" xlink:label="us-gaap_AccruedEmployeeBenefitsCurrent_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent" xlink:to="us-gaap_AccruedEmployeeBenefitsCurrent_637323311126623354" order="2" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="iova-20200630.xsd#iova_ManufacturingRelatedExpensesCurrent" xlink:label="iova_ManufacturingRelatedExpensesCurrent_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent" xlink:to="iova_ManufacturingRelatedExpensesCurrent_637323311126623354" order="3" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="iova-20200630.xsd#iova_CommercialManufacturingFacilityRelatedCurrent" xlink:label="iova_CommercialManufacturingFacilityRelatedCurrent_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent" xlink:to="iova_CommercialManufacturingFacilityRelatedCurrent_637323311126623354" order="4" use="optional" weight="1" priority="2"/>
<loc xlink:type="locator" xlink:href="iova-20200630.xsd#iova_LegalAndRelatedServicesCurrent" xlink:label="iova_LegalAndRelatedServicesCurrent_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent" xlink:to="iova_LegalAndRelatedServicesCurrent_637323311126623354" order="5" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrent" xlink:label="us-gaap_OtherAccruedLiabilitiesCurrent_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent" xlink:to="us-gaap_OtherAccruedLiabilitiesCurrent_637323311126623354" order="6" use="optional" weight="1"/>
</calculationLink>
<calculationLink xlink:role="http://lbio.com/role/DisclosureLeasesCompanySRightOfUseAssetAndLeaseLiabilitiesDetails" xlink:type="extended" xlink:title="40901 - Disclosure - LEASES - Company's right-of-use asset and lease liabilities (Details)">
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeaseLiability" xlink:label="us-gaap_OperatingLeaseLiability_636970526555412622"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent" xlink:label="us-gaap_OperatingLeaseLiabilityCurrent_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_OperatingLeaseLiability_636970526555412622" xlink:to="us-gaap_OperatingLeaseLiabilityCurrent_637323311126623354" order="1" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent" xlink:label="us-gaap_OperatingLeaseLiabilityNoncurrent_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_OperatingLeaseLiability_636970526555412622" xlink:to="us-gaap_OperatingLeaseLiabilityNoncurrent_637323311126623354" order="2" use="optional" weight="1"/>
</calculationLink>
<calculationLink xlink:role="http://lbio.com/role/DisclosureLeasesComponentsOfLeaseExpensesDetails" xlink:type="extended" xlink:title="40902 - Disclosure - LEASES - components of lease expenses (Details)">
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LeaseCost" xlink:label="us-gaap_LeaseCost_636970526555442622"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeaseCost" xlink:label="us-gaap_OperatingLeaseCost_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_LeaseCost_636970526555442622" xlink:to="us-gaap_OperatingLeaseCost_637323311126623354" order="1" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_VariableLeaseCost" xlink:label="us-gaap_VariableLeaseCost_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_LeaseCost_636970526555442622" xlink:to="us-gaap_VariableLeaseCost_637323311126623354" order="2" use="optional" weight="1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortTermLeaseCost" xlink:label="us-gaap_ShortTermLeaseCost_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_LeaseCost_636970526555442622" xlink:to="us-gaap_ShortTermLeaseCost_637323311126623354" order="3" use="optional" weight="1"/>
</calculationLink>
<calculationLink xlink:role="http://lbio.com/role/DisclosureLeasesMaturitiesOfCompanySOperatingLeaseLiabilitiesDetails" xlink:type="extended" xlink:title="40903 - Disclosure - LEASES - maturities of the Company's operating lease liabilities (Details)">
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDue"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:to="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_637323311126623354" order="1" use="optional" weight="1" priority="2"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:to="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_637323311126623354" order="2" use="optional" weight="1" priority="2"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:to="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_637323311126623354" order="3" use="optional" weight="1" priority="2"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:to="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_637323311126623354" order="4" use="optional" weight="1" priority="2"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:to="us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter_637323311126623354" order="5" use="optional" weight="1" priority="2"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsRemainderOfFiscalYear" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsRemainderOfFiscalYear_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:to="us-gaap_OperatingLeasesFutureMinimumPaymentsRemainderOfFiscalYear_637323311126623354" order="6" use="optional" weight="1" priority="2"/>
</calculationLink>
<calculationLink xlink:role="http://lbio.com/role/DisclosureLeasesMaturitiesOfCompanySOperatingLeaseLiabilitiesDetailsCalc2" xlink:type="extended" xlink:title="41003 - Disclosure - LEASES - maturities of the Company's operating lease liabilities (Details) Calc 2">
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDue"/>
<loc xlink:type="locator" xlink:href="iova-20200630.xsd#iova_OperatingLeasePresentValueAdjustments" xlink:label="iova_OperatingLeasePresentValueAdjustments_637323311126623354"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:to="iova_OperatingLeasePresentValueAdjustments_637323311126623354" order="1" use="optional" weight="-1" priority="2"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeaseLiability" xlink:label="us-gaap_OperatingLeaseLiability_637323311126724109"/>
<calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:to="us-gaap_OperatingLeaseLiability_637323311126724109" order="2" use="optional" weight="1" priority="2"/>
</calculationLink>
</linkbase>


6 Subsequent Filings that Reference this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 2/28/24  Iovance Biotherapeutics, Inc.     10-K       12/31/23   95:11M                                    Toppan Merrill Bridge/FA
 2/28/23  Iovance Biotherapeutics, Inc.     10-K       12/31/22   78:10M                                    Toppan Merrill Bridge/FA
 2/24/22  Iovance Biotherapeutics, Inc.     10-K       12/31/21   79:10M                                    Toppan Merrill Bridge/FA
 2/25/21  Iovance Biotherapeutics, Inc.     10-K       12/31/20   84:11M                                    Toppan Merrill Bridge/FA
 2/09/21  Iovance Biotherapeutics, Inc.     424B5                  1:799K                                   Toppan Merrill/FA
11/05/20  Iovance Biotherapeutics, Inc.     10-Q        9/30/20   62:7.8M                                   Toppan Merrill Bridge/FA


3 Previous Filings that this Filing References

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 6/09/20  Iovance Biotherapeutics, Inc.     8-K:5,9     6/08/20   12:480K                                   Toppan Merrill/FA
 5/27/20  Iovance Biotherapeutics, Inc.     8-K:5,8,9   5/27/20   12:508K                                   Toppan Merrill/FA
 2/25/20  Iovance Biotherapeutics, Inc.     10-K       12/31/19   88:11M                                    Toppan Merrill/FA
Top
Filing Submission 0001104659-20-091526   –   Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)

Copyright © 2024 Fran Finnegan & Company LLC – All Rights Reserved.
AboutPrivacyRedactionsHelp — Sat., Apr. 27, 10:42:00.1pm ET