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Ownership Document
|
| Schema Version: X0306 |
| Document Type: 4 |
| Period of Report: 8/31/22 |
| Not Subject to Section 16: 0 |
| Issuer: |
| Issuer CIK: 874015 |
| Issuer Name: IONIS PHARMACEUTICALS INC |
| Issuer Trading Symbol: IONS |
| Reporting Owner: |
| Reporting Owner ID: |
| | Owner CIK: 1074773 |
| | Owner Name: HOUGEN ELIZABETH L |
| Reporting Owner Address: |
| | Owner Street 1: 2855 GAZELLE COURT |
| | Owner Street 2: |
| | Owner City: CARLSBAD |
| | Owner State: CA |
| | Owner ZIP Code: 92010 |
| | Owner State Description: |
| Reporting Owner Relationship: |
| | Is Director? No |
| | Is Officer? Yes |
| | Is Ten Percent Owner? No |
| | Is Other? No |
| | Officer Title: EVP, Finance & CFO |
| Non-Derivative Table: |
| Non-Derivative Transaction: |
| | Security Title: |
| | | Value: Common Stock |
| | Transaction Date: |
| | | Value: 8/31/22 |
| | Transaction Coding: |
| | | Transaction Form Type: 4 |
| | | Transaction Code: J |
| | | Equity Swap Involved? No |
| | | Footnote ID: F1 |
| | Transaction Amounts: |
| | | Transaction Shares: |
| Value: 202 |
| | | Transaction Price Per Share: |
| Value: 28.968 |
| | | Transaction Acquired-Disposed Code: |
| Value: A |
| | Post-Transaction Amounts: |
| | | Shares Owned Following Transaction: |
| Value: 58,561 |
| | Ownership Nature: |
| | | Direct or Indirect Ownership: |
| Value: D |
| Footnotes: |
| Footnote - F1: Reporting shares acquired under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on August 31, 2022. These shares may not be sold until February 28, 2023. |
| Owner Signature: |
| Signature Name: By: Patrick R. O'Neil, attorney-in-fact For: Elizabeth L. Hougen |
| Signature Date: 9/1/22 |
