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<?xml version="1.0" encoding="windows-1252"?> |
<ownershipDocument> |
| <schemaVersion> X0306 </schemaVersion> |
| <documentType> 4 </documentType> |
| <periodOfReport> 2021-05-13 </periodOfReport> |
| <issuer> |
| | <issuerCik> 0001053691 </issuerCik> |
| | <issuerName> Diffusion Pharmaceuticals Inc. </issuerName> |
| | <issuerTradingSymbol> DFFN </issuerTradingSymbol> |
| | </issuer> |
| <reportingOwner> |
| | <reportingOwnerId> |
| | | <rptOwnerCik> 0001297141 </rptOwnerCik> |
| | | <rptOwnerName> Hollingsworth Jane H </rptOwnerName> |
| | | </reportingOwnerId> |
| | <reportingOwnerAddress> |
| | | <rptOwnerStreet1> 1317 CARLTON AVE </rptOwnerStreet1> |
| | | <rptOwnerStreet2> SUITE 200 </rptOwnerStreet2> |
| | | <rptOwnerCity> CHARLOTTESVILLE </rptOwnerCity> |
| | | <rptOwnerState> VA </rptOwnerState> |
| | | <rptOwnerZipCode> 22902 </rptOwnerZipCode> |
| | | <rptOwnerStateDescription></rptOwnerStateDescription> |
| | | </reportingOwnerAddress> |
| | <reportingOwnerRelationship> |
| | | <isDirector> 1 </isDirector> |
| | | </reportingOwnerRelationship> |
| | </reportingOwner> |
| <nonDerivativeTable> |
| | <nonDerivativeTransaction> |
| | | <securityTitle> |
| <value> Common Stock </value> |
| </securityTitle> |
| | | <transactionDate> |
| <value> 2021-05-13 </value> |
| </transactionDate> |
| | | <transactionCoding> |
| <transactionFormType> 4 </transactionFormType> |
| <transactionCode> P </transactionCode> |
| <equitySwapInvolved> 0 </equitySwapInvolved> |
| </transactionCoding> |
| | | <transactionAmounts> |
| <transactionShares> |
| <value> 32786 </value> |
| </transactionShares> |
| <transactionPricePerShare> |
| <value> 0.61 </value> |
| <footnoteId id="F1"/> |
| </transactionPricePerShare> |
| <transactionAcquiredDisposedCode> |
| <value> A </value> |
| </transactionAcquiredDisposedCode> |
| </transactionAmounts> |
| | | <postTransactionAmounts> |
| <sharesOwnedFollowingTransaction> |
| <value> 32786 </value> |
| </sharesOwnedFollowingTransaction> |
| </postTransactionAmounts> |
| | | <ownershipNature> |
| <directOrIndirectOwnership> |
| <value> D </value> |
| </directOrIndirectOwnership> |
| </ownershipNature> |
| | | </nonDerivativeTransaction> |
| | </nonDerivativeTable> |
| <footnotes> |
| | <footnote id="F1"> The price reported is a weighted average price. The shares were purchased in multiple open-market transactions at prices ranging from $0.6097 to $0.6141, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full detail regarding the number of shares sold at each separate price within such range. </footnote> |
| | </footnotes> |
| <ownerSignature> |
| | <signatureName> /s/ William R. Elder, attorney-in-fact for the Reporting Person </signatureName> |
| | <signatureDate> 2021-05-17 </signatureDate> |
| | </ownerSignature> |
| </ownershipDocument> |