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| <?xml version="1.0" encoding="windows-1252"?> |
| <ownershipDocument> |
| <schemaVersion> X0306 </schemaVersion> |
| <documentType> 4 </documentType> |
| <periodOfReport> 2022-09-15 </periodOfReport> |
| <notSubjectToSection16> 0 </notSubjectToSection16> |
| <issuer> |
| | <issuerCik> 0001169987 </issuerCik> |
| | <issuerName> HTG MOLECULAR DIAGNOSTICS, INC </issuerName> |
| | <issuerTradingSymbol> HTGM </issuerTradingSymbol> |
| | </issuer> |
| <reportingOwner> |
| | <reportingOwnerId> |
| | | <rptOwnerCik> 0001261156 </rptOwnerCik> |
| | | <rptOwnerName> KIRITSY CHRISTOPHER P </rptOwnerName> |
| | | </reportingOwnerId> |
| | <reportingOwnerAddress> |
| | | <rptOwnerStreet1> C/O HTG MOLECULAR DIAGNOSTICS, INC. </rptOwnerStreet1> |
| | | <rptOwnerStreet2> 3430 E. GLOBAL LOOP </rptOwnerStreet2> |
| | | <rptOwnerCity> TUCSON </rptOwnerCity> |
| | | <rptOwnerState> AZ </rptOwnerState> |
| | | <rptOwnerZipCode> 85706 </rptOwnerZipCode> |
| | | <rptOwnerStateDescription></rptOwnerStateDescription> |
| | | </reportingOwnerAddress> |
| | <reportingOwnerRelationship> |
| | | <isDirector> 1 </isDirector> |
| | | <isOfficer> 0 </isOfficer> |
| | | <isTenPercentOwner> 0 </isTenPercentOwner> |
| | | <isOther> 0 </isOther> |
| | | </reportingOwnerRelationship> |
| | </reportingOwner> |
| <derivativeTable> |
| | <derivativeTransaction> |
| | | <securityTitle> |
| <value> Stock Option (right to buy) </value> |
| </securityTitle> |
| | | <conversionOrExercisePrice> |
| <value> 0.86 </value> |
| </conversionOrExercisePrice> |
| | | <transactionDate> |
| <value> 2022-09-15 </value> |
| </transactionDate> |
| | | <deemedExecutionDate></deemedExecutionDate> |
| | | <transactionCoding> |
| <transactionFormType> 4 </transactionFormType> |
| <transactionCode> A </transactionCode> |
| <equitySwapInvolved> 0 </equitySwapInvolved> |
| </transactionCoding> |
| | | <transactionTimeliness> |
| <value></value> |
| </transactionTimeliness> |
| | | <transactionAmounts> |
| <transactionShares> |
| <value> 4000 </value> |
| </transactionShares> |
| <transactionPricePerShare> |
| <value> 0.00 </value> |
| </transactionPricePerShare> |
| <transactionAcquiredDisposedCode> |
| <value> A </value> |
| </transactionAcquiredDisposedCode> |
| </transactionAmounts> |
| | | <exerciseDate> |
| <footnoteId id="F1"/> |
| </exerciseDate> |
| | | <expirationDate> |
| <value> 2032-09-14 </value> |
| </expirationDate> |
| | | <underlyingSecurity> |
| <underlyingSecurityTitle> |
| <value> Common Stock </value> |
| </underlyingSecurityTitle> |
| <underlyingSecurityShares> |
| <value> 4000 </value> |
| </underlyingSecurityShares> |
| </underlyingSecurity> |
| | | <postTransactionAmounts> |
| <sharesOwnedFollowingTransaction> |
| <value> 4000 </value> |
| </sharesOwnedFollowingTransaction> |
| </postTransactionAmounts> |
| | | <ownershipNature> |
| <directOrIndirectOwnership> |
| <value> D </value> |
| </directOrIndirectOwnership> |
| </ownershipNature> |
| | | </derivativeTransaction> |
| | </derivativeTable> |
| <footnotes> |
| | <footnote id="F1"> The shares will vest on the earlier of September 15, 2023 or the date of the next annual meeting of stockholders. </footnote> |
| | </footnotes> |
| <remarks></remarks> |
| <ownerSignature> |
| | <signatureName> /s/ Shaun D. McMeans, Attorney-in-Fact </signatureName> |
| | <signatureDate> 2022-09-15 </signatureDate> |
| | </ownerSignature> |
| </ownershipDocument> |
