As Of	Filer	Filing¹	For·On·As	Docs:Size	Issuer		Filing Agent

 2/24/21  Ionis Pharmaceuticals Inc.        10-K       12/31/20  111:23M                                                             
  1/6/21  Crooke Stanley T                  5          Dir.,Off.²  1:4K   Ionis Pharmaceuticals Inc.        Ionis Pharmas Inc.       
12/31/20  Ionis Pharmaceuticals Inc.        S-8        12/31/20    7:376K                                   Broadridge Fin’l So… Inc 

____________
¹	Filing/Form Types:
	5	Annual Statement of Changes in Beneficial Ownership of Securities by an Insider — Form 5 { The Filer is an Insider² of the Issuer }.
	10-K	Annual Report — Form 10-K.
	S-8	Registration Statement – Securities for an Employee Benefit Plan — Form S-8.
²	Insider:  The Filer is a Director, Officer, 10% Owner and/or Other “insider” of the Issuer.