As Of	Filer	Filing¹	For·On·As	Docs:Size	Issuer		Filing Agent

  5/5/16‡ Ionis Pharmaceuticals Inc.        10-Q        3/31/16   53:5.9M                                                            
  4/1/16  Crooke Stanley T                  4          Dir.,Off.²  1:17K  Ionis Pharmaceuticals Inc.        Ionis Pharmas Inc.       

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‡	A non-Insider-Ownership Filing that was accepted after the SEC “closed” at 5:30:00pm ET.  The legal “Filed As Of” date may be the next, or another, day.
¹	Filing/Form Types:
	4	Statement of Changes in Beneficial Ownership of Securities by an Insider — Form 4 { The Filer is an Insider² of the Issuer }.
	10-Q	Quarterly Report — Form 10-Q.
²	Insider:  The Filer is a Director, Officer, 10% Owner and/or Other “insider” of the Issuer.