As Of	Filer	Filing¹	For·On·As	Docs:Size	Issuer		Filing Agent

 2/14/20  Boxer Capital, LLC                SC 13G/A               1:101K Medicines Co./DE                  Donnelley … Solutions/FA 
          Avid Group Ltd.³
          Boxer Asset Management Inc.³
          Braslyn Ltd.³
          Joe Lewis³
          Tuesday Thirteen Inc.³
 2/12/20  Vanguard Group Inc.               SC 13G/A               1:13K  Medicines Co./DE                  Toppan Merrill/FA        
 2/12/20  Vanguard Specialized Funds        SC 13G/A               1:12K  Medicines Co./DE                  Toppan Merrill/FA        
 2/10/20  BlackRock Inc.                    SC 13G/A               1:13K  Medicines Co./DE                  Blackrock Global Al… Inc 
 1/28/20  Iridian Asset Management LLC/CT   SC 13G/A               1:39K  Medicines Co./DE                                           
 1/16/20  Medicines Co./DE                  15-12G      1/16/20    1:23K                                    Toppan Merrill/FA        
  1/9/20‡ Medicines Co./DE                  EFFECT       1/9/20    1:2K                                     SEC #5                   
  1/9/20‡ Medicines Co./DE                  EFFECT       1/9/20    1:2K                                     SEC #5                   
  1/9/20‡ Medicines Co./DE                  EFFECT       1/9/20    1:2K                                     SEC #5                   
  1/7/20  Sarissa Capital Management LP     SC 13D/A               1:76K  Medicines Co./DE                  Willkie Farr & Gallagher 
          Alexander J. Denner³
          Sarissa Capital Athena Fund Ltd.³
          Sarissa Capital Catapult Fund LLC³
          Sarissa Capital Hawkeye Fund LP³
          Sarissa Capital Offshore Master Fund LP³
  1/7/20  Westfield Capital Mgmt Co. LP     SC 13G/A               1:19K  Medicines Co./DE                  Adv Consultant Netw… Inc 
  1/6/20  Wijngaard Peter                   4          Officer²    1:16K  Medicines Co./DE                  Paul Weiss Ri… LLP 01/FA 
  1/6/20  Visioli Christopher               4          Officer²    1:8K   Medicines Co./DE                  Paul Weiss Ri… LLP 01/FA 
  1/6/20  Timney Mark                       4          Dir.,Off.²  1:12K  Medicines Co./DE                  Paul Weiss Ri… LLP 01/FA 
  1/6/20  Schlesinger Sarah J.              4          Director²   1:10K  Medicines Co./DE                  Paul Weiss Ri… LLP 01/FA 
  1/6/20  Rodin Stephen M                   4          Officer²    1:12K  Medicines Co./DE                  Paul Weiss Ri… LLP 01/FA 
  1/6/20  Panayiotopoulos Paris             4          Director²   1:11K  Medicines Co./DE                  Paul Weiss Ri… LLP 01/FA 
  1/6/20  Meanwell Clive                    4          Dir.,Off.²  1:18K  Medicines Co./DE                  Paul Weiss Ri… LLP 01/FA 
  1/6/20  Kelly John C.                     4          Director²   1:46K  Medicines Co./DE                  Paul Weiss Ri… LLP 01/FA 
  1/6/20  Germano Geno J                    4          Director²   1:10K  Medicines Co./DE                  Paul Weiss Ri… LLP 01/FA 

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‡	A non-Insider-Ownership Filing that was accepted after the SEC “closed” at 5:30:00pm ET.  The legal “Filed As Of” date may be the next, or another, day.
¹	Filing/Form Types:  /A
	4	Statement of Changes in Beneficial Ownership of Securities by an Insider — Form 4 { The Filer is an Insider² of the Issuer }.
	15-12G	Certification of a Termination of Registration of a Class of Securities — Form 15.
	EFFECT	SEC Notice of Effectiveness.
	SC 13D	Statement of Acquisition of Beneficial Ownership by an “Active” Investor — Schedule 13D.
	SC 13G	Statement of Acquisition of Beneficial Ownership by a “Passive” Investor — Schedule 13G.
	/A	Amendment to, or Amended version of, a previous Filing of this Type.
²	Insider:  The Filer is a Director, Officer, 10% Owner and/or Other “insider” of the Issuer.
³	Group Member:  A Registrant or non-Registrant party to this Filing made by a Group.