| | | | | | | | | | | | | | | | | | | | | |
<?xml version="1.0" encoding="windows-1252"?> |
<!-- XBRL Document Created with the Workiva Platform --> |
<!-- Copyright 2023 Workiva --> |
<!-- r:86a97863-9a18-4636-af43-fee1439e2a23,g:8d78583a-eaed-4025-8796-17e85358e13e --> |
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"> |
| <link:roleRef roleURI="http://www.exelixis.com/role/CondensedConsolidatedBalanceSheets" xlink:type="simple" xlink:href="exel-20230630.xsd#CondensedConsolidatedBalanceSheets"/> |
| <link:calculationLink xlink:role="http://www.exelixis.com/role/CondensedConsolidatedBalanceSheets" xlink:type="extended"> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_a2992517-3c4a-4dbe-8561-bdfb86e57b85" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquity"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_93cae92f-14b3-4116-a5bd-ac3ad26d039e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PreferredStockValue"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_a2992517-3c4a-4dbe-8561-bdfb86e57b85" xlink:to="loc_us-gaap_PreferredStockValue_93cae92f-14b3-4116-a5bd-ac3ad26d039e" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_8c70d30a-9513-43c3-be1b-b8d350dd4c08" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockValue"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_a2992517-3c4a-4dbe-8561-bdfb86e57b85" xlink:to="loc_us-gaap_CommonStockValue_8c70d30a-9513-43c3-be1b-b8d350dd4c08" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_5f96a8cc-bda5-48e6-a2a5-fbd23a3f62d8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdditionalPaidInCapital"/> |
| | <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_a2992517-3c4a-4dbe-8561-bdfb86e57b85" xlink:to="loc_us-gaap_AdditionalPaidInCapital_5f96a8cc-bda5-48e6-a2a5-fbd23a3f62d8" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_2cb967a0-d6e6-4054-8306-7785383bfdc3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/> |
| | <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_a2992517-3c4a-4dbe-8561-bdfb86e57b85" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_2cb967a0-d6e6-4054-8306-7785383bfdc3" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_917ddc3b-e008-4545-802b-708ea6e6c5b1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/> |
| | <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_a2992517-3c4a-4dbe-8561-bdfb86e57b85" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_917ddc3b-e008-4545-802b-708ea6e6c5b1" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_84201d28-f0c7-4e1e-8ca9-ace7ff40f87f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Assets"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_ad76f824-0035-40bb-bbb1-2738d82ee736" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentNet"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_84201d28-f0c7-4e1e-8ca9-ace7ff40f87f" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_ad76f824-0035-40bb-bbb1-2738d82ee736" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_exel_OperatingLeaseRightOfUseAssetAndOtherAssets_5c5d832c-02a9-4bc5-bc58-fb5cdeb08789" xlink:href="exel-20230630.xsd#exel_OperatingLeaseRightOfUseAssetAndOtherAssets"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_84201d28-f0c7-4e1e-8ca9-ace7ff40f87f" xlink:to="loc_exel_OperatingLeaseRightOfUseAssetAndOtherAssets_5c5d832c-02a9-4bc5-bc58-fb5cdeb08789" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_473877cc-c896-4908-8158-a5b759b03252" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Goodwill"/> |
| | <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_84201d28-f0c7-4e1e-8ca9-ace7ff40f87f" xlink:to="loc_us-gaap_Goodwill_473877cc-c896-4908-8158-a5b759b03252" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermInvestments_4136f425-a97c-43ac-970f-7719f572c680" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermInvestments"/> |
| | <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_84201d28-f0c7-4e1e-8ca9-ace7ff40f87f" xlink:to="loc_us-gaap_LongTermInvestments_4136f425-a97c-43ac-970f-7719f572c680" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_3d8548f8-d494-4e19-ae5c-585a307c760c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/> |
| | <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_84201d28-f0c7-4e1e-8ca9-ace7ff40f87f" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_3d8548f8-d494-4e19-ae5c-585a307c760c" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_ee3fa861-aead-4638-b963-202a46434e2f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsCurrent"/> |
| | <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_84201d28-f0c7-4e1e-8ca9-ace7ff40f87f" xlink:to="loc_us-gaap_AssetsCurrent_ee3fa861-aead-4638-b963-202a46434e2f" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_7134af6f-8f65-4254-9fd0-e56e54197706" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsCurrent"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_e1792491-97f9-461f-b04a-9a9f9f1787d4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShortTermInvestments"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_7134af6f-8f65-4254-9fd0-e56e54197706" xlink:to="loc_us-gaap_ShortTermInvestments_e1792491-97f9-461f-b04a-9a9f9f1787d4" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesNetCurrent_e545dfbc-44bd-4bd4-a1ca-958fb89210c6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ReceivablesNetCurrent"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_7134af6f-8f65-4254-9fd0-e56e54197706" xlink:to="loc_us-gaap_ReceivablesNetCurrent_e545dfbc-44bd-4bd4-a1ca-958fb89210c6" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_9a8b1b7d-15d8-4d24-b932-f65d35748306" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/> |
| | <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_7134af6f-8f65-4254-9fd0-e56e54197706" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_9a8b1b7d-15d8-4d24-b932-f65d35748306" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_21855ade-22cf-46f3-b570-188d90aff1e1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/> |
| | <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_7134af6f-8f65-4254-9fd0-e56e54197706" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_21855ade-22cf-46f3-b570-188d90aff1e1" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_0cc668f2-bd8a-4e6f-880d-cdcb068ea081" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryNet"/> |
| | <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_7134af6f-8f65-4254-9fd0-e56e54197706" xlink:to="loc_us-gaap_InventoryNet_0cc668f2-bd8a-4e6f-880d-cdcb068ea081" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_3354cea4-3030-476f-b1e4-65847fd1feb1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesCurrent"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_19c3f328-740b-43a4-b165-83f37722f024" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsPayableCurrent"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_3354cea4-3030-476f-b1e4-65847fd1feb1" xlink:to="loc_us-gaap_AccountsPayableCurrent_19c3f328-740b-43a4-b165-83f37722f024" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedEmployeeBenefitsCurrent_ce7d7e34-7e97-485f-a349-82372d23f32b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccruedEmployeeBenefitsCurrent"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_3354cea4-3030-476f-b1e4-65847fd1feb1" xlink:to="loc_us-gaap_AccruedEmployeeBenefitsCurrent_ce7d7e34-7e97-485f-a349-82372d23f32b" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_exel_AccruedClinicalLiabilitiesCurrent_cbda3a5a-154a-4b2d-951d-b760ed184da3" xlink:href="exel-20230630.xsd#exel_AccruedClinicalLiabilitiesCurrent"/> |
| | <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_3354cea4-3030-476f-b1e4-65847fd1feb1" xlink:to="loc_exel_AccruedClinicalLiabilitiesCurrent_cbda3a5a-154a-4b2d-951d-b760ed184da3" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerRefundLiabilityCurrent_a5ffb05f-e0d5-40b3-a6dc-5a31bd96906d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CustomerRefundLiabilityCurrent"/> |
| | <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_3354cea4-3030-476f-b1e4-65847fd1feb1" xlink:to="loc_us-gaap_CustomerRefundLiabilityCurrent_a5ffb05f-e0d5-40b3-a6dc-5a31bd96906d" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_exel_AccruedCollaborationLiabilityCurrent_df6445e8-3159-429f-817b-e5616f1b78dc" xlink:href="exel-20230630.xsd#exel_AccruedCollaborationLiabilityCurrent"/> |
| | <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_3354cea4-3030-476f-b1e4-65847fd1feb1" xlink:to="loc_exel_AccruedCollaborationLiabilityCurrent_df6445e8-3159-429f-817b-e5616f1b78dc" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_36e2cf47-5b69-411c-ad89-74c0cb7b9939" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/> |
| | <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_3354cea4-3030-476f-b1e4-65847fd1feb1" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_36e2cf47-5b69-411c-ad89-74c0cb7b9939" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_80a6868c-fa5f-498d-9953-f25523c8ce99" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Liabilities"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_4e234982-4e19-44b8-9322-eb9717c0b675" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesCurrent"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_80a6868c-fa5f-498d-9953-f25523c8ce99" xlink:to="loc_us-gaap_LiabilitiesCurrent_4e234982-4e19-44b8-9322-eb9717c0b675" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_ea68adaf-ae14-47b3-8ad5-5ffb85d7439b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_80a6868c-fa5f-498d-9953-f25523c8ce99" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_ea68adaf-ae14-47b3-8ad5-5ffb85d7439b" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_a37b6477-94ed-4cfc-ac96-a7aadc5e7985" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/> |
| | <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_80a6868c-fa5f-498d-9953-f25523c8ce99" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_a37b6477-94ed-4cfc-ac96-a7aadc5e7985" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_671257f8-898d-4da9-a5b6-9203dcc171ce" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherLiabilitiesNoncurrent"/> |
| | <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_80a6868c-fa5f-498d-9953-f25523c8ce99" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_671257f8-898d-4da9-a5b6-9203dcc171ce" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_e2851de0-8f36-42e9-9910-c34ab884e105" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_15568ae0-baa9-4343-aec8-911052363694" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Liabilities"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_e2851de0-8f36-42e9-9910-c34ab884e105" xlink:to="loc_us-gaap_Liabilities_15568ae0-baa9-4343-aec8-911052363694" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_86eddbc1-839c-4cfe-9b6d-e4878a11149c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommitmentsAndContingencies"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_e2851de0-8f36-42e9-9910-c34ab884e105" xlink:to="loc_us-gaap_CommitmentsAndContingencies_86eddbc1-839c-4cfe-9b6d-e4878a11149c" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_24f98adb-3013-4e93-99d1-d06f9c0a60e1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquity"/> |
| | <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_e2851de0-8f36-42e9-9910-c34ab884e105" xlink:to="loc_us-gaap_StockholdersEquity_24f98adb-3013-4e93-99d1-d06f9c0a60e1" xlink:type="arc"/> |
| | </link:calculationLink> |
| <link:roleRef roleURI="http://www.exelixis.com/role/CondensedConsolidatedStatementsofIncome" xlink:type="simple" xlink:href="exel-20230630.xsd#CondensedConsolidatedStatementsofIncome"/> |
| <link:calculationLink xlink:role="http://www.exelixis.com/role/CondensedConsolidatedStatementsofIncome" xlink:type="extended"> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossAttributableToParent_4ec8bf44-7282-4e0a-9901-c02ccb5886d1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossAttributableToParent"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_b39d3071-8a77-40d1-b0f8-7253759b15de" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingIncomeLoss"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossAttributableToParent_4ec8bf44-7282-4e0a-9901-c02ccb5886d1" xlink:to="loc_us-gaap_OperatingIncomeLoss_b39d3071-8a77-40d1-b0f8-7253759b15de" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeOther_255a84d5-4e79-4946-911e-cdf13a817b67" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestIncomeOther"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossAttributableToParent_4ec8bf44-7282-4e0a-9901-c02ccb5886d1" xlink:to="loc_us-gaap_InterestIncomeOther_255a84d5-4e79-4946-911e-cdf13a817b67" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_15b8ff6a-a94c-44c9-b030-df38738bef8e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherNonoperatingIncomeExpense"/> |
| | <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossAttributableToParent_4ec8bf44-7282-4e0a-9901-c02ccb5886d1" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_15b8ff6a-a94c-44c9-b030-df38738bef8e" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_86040535-78b2-4e03-9503-faa423caaa6f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossAttributableToParent_512dde48-7a45-419c-b182-ddb8d80d7cb7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossAttributableToParent"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_86040535-78b2-4e03-9503-faa423caaa6f" xlink:to="loc_us-gaap_IncomeLossAttributableToParent_512dde48-7a45-419c-b182-ddb8d80d7cb7" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_5c2f2145-0668-411d-b83b-a93741e35e62" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxExpenseBenefit"/> |
| | <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_86040535-78b2-4e03-9503-faa423caaa6f" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_5c2f2145-0668-411d-b83b-a93741e35e62" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_03550b23-6265-428e-b5a3-154a0bc1a118" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingIncomeLoss"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_a1ef5d5f-2088-4795-8383-a131f33458ce" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostsAndExpenses"/> |
| | <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_03550b23-6265-428e-b5a3-154a0bc1a118" xlink:to="loc_us-gaap_CostsAndExpenses_a1ef5d5f-2088-4795-8383-a131f33458ce" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_c6fe3dec-ac69-48f7-9132-98916a5ed194" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_03550b23-6265-428e-b5a3-154a0bc1a118" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_c6fe3dec-ac69-48f7-9132-98916a5ed194" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_c640f1dc-b06c-448e-827f-1e4883553326" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostsAndExpenses"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_cf367eda-7fa2-4f51-9f36-acd570ffd6a2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostOfGoodsAndServicesSold"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_c640f1dc-b06c-448e-827f-1e4883553326" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_cf367eda-7fa2-4f51-9f36-acd570ffd6a2" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_cd44b886-7ccd-4dd1-9b69-37024789b54e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentExpense"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_c640f1dc-b06c-448e-827f-1e4883553326" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_cd44b886-7ccd-4dd1-9b69-37024789b54e" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_2be1c75b-a818-4e35-ac96-90717807cea1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/> |
| | <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_c640f1dc-b06c-448e-827f-1e4883553326" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_2be1c75b-a818-4e35-ac96-90717807cea1" xlink:type="arc"/> |
| | </link:calculationLink> |
| <link:roleRef roleURI="http://www.exelixis.com/role/CondensedConsolidatedStatementsofComprehensiveIncome" xlink:type="simple" xlink:href="exel-20230630.xsd#CondensedConsolidatedStatementsofComprehensiveIncome"/> |
| <link:calculationLink xlink:role="http://www.exelixis.com/role/CondensedConsolidatedStatementsofComprehensiveIncome" xlink:type="extended"> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_410e338a-a2b6-4a63-b8e5-ccc7085737a4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_cca1869b-29ed-41e8-8c79-6608a6ccbbf6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_410e338a-a2b6-4a63-b8e5-ccc7085737a4" xlink:to="loc_us-gaap_NetIncomeLoss_cca1869b-29ed-41e8-8c79-6608a6ccbbf6" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_c2bc5f77-31cf-4a91-8e97-b8ddff8e3af8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_410e338a-a2b6-4a63-b8e5-ccc7085737a4" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_c2bc5f77-31cf-4a91-8e97-b8ddff8e3af8" xlink:type="arc"/> |
| | </link:calculationLink> |
| <link:roleRef roleURI="http://www.exelixis.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="exel-20230630.xsd#CondensedConsolidatedStatementsofCashFlows"/> |
| <link:calculationLink xlink:role="http://www.exelixis.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="extended"> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_cbfe0073-ccd8-4d88-a6ac-676d19b6c10b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_3ab7afc7-3f0f-4500-99b0-674683adad4f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_cbfe0073-ccd8-4d88-a6ac-676d19b6c10b" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_3ab7afc7-3f0f-4500-99b0-674683adad4f" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_dcfca90d-61f5-4b37-8def-32e3ecde8bd4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_cbfe0073-ccd8-4d88-a6ac-676d19b6c10b" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_dcfca90d-61f5-4b37-8def-32e3ecde8bd4" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_bd8d154c-39d7-4d31-9705-287e37d2c531" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/> |
| | <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_cbfe0073-ccd8-4d88-a6ac-676d19b6c10b" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_bd8d154c-39d7-4d31-9705-287e37d2c531" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7ff4424f-d25d-4af0-a992-6893641d70c0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_f4b1ad39-d037-4271-ad7b-799291115f0a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/> |
| | <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7ff4424f-d25d-4af0-a992-6893641d70c0" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_f4b1ad39-d037-4271-ad7b-799291115f0a" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireInvestments_f0405e4d-ef55-4fb1-a12c-db638b6cb296" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquireInvestments"/> |
| | <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7ff4424f-d25d-4af0-a992-6893641d70c0" xlink:to="loc_us-gaap_PaymentsToAcquireInvestments_f0405e4d-ef55-4fb1-a12c-db638b6cb296" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments_ebd3b5e1-f8ce-44c4-831f-7046ef7692ce" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments"/> |
| | <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7ff4424f-d25d-4af0-a992-6893641d70c0" xlink:to="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments_ebd3b5e1-f8ce-44c4-831f-7046ef7692ce" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireInProcessResearchAndDevelopment_f56c8670-8882-43f0-921a-1637b0fa5062" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquireInProcessResearchAndDevelopment"/> |
| | <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7ff4424f-d25d-4af0-a992-6893641d70c0" xlink:to="loc_us-gaap_PaymentsToAcquireInProcessResearchAndDevelopment_f56c8670-8882-43f0-921a-1637b0fa5062" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e6c860c3-7dc9-43ac-ab9c-33f89b0b0cef" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_d21469bb-d903-4fc8-917a-7eeea580eb8c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e6c860c3-7dc9-43ac-ab9c-33f89b0b0cef" xlink:to="loc_us-gaap_NetIncomeLoss_d21469bb-d903-4fc8-917a-7eeea580eb8c" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_72b036d3-d737-4d1e-b4a9-5a3d796b354d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DepreciationDepletionAndAmortization"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e6c860c3-7dc9-43ac-ab9c-33f89b0b0cef" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_72b036d3-d737-4d1e-b4a9-5a3d796b354d" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_429839bb-967f-4ff9-b7fe-c2f7871aed3c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensation"/> |
| | <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e6c860c3-7dc9-43ac-ab9c-33f89b0b0cef" xlink:to="loc_us-gaap_ShareBasedCompensation_429839bb-967f-4ff9-b7fe-c2f7871aed3c" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_exel_NoncashLeaseExpense_7466379f-977e-4935-991e-a7d0be3970a5" xlink:href="exel-20230630.xsd#exel_NoncashLeaseExpense"/> |
| | <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e6c860c3-7dc9-43ac-ab9c-33f89b0b0cef" xlink:to="loc_exel_NoncashLeaseExpense_7466379f-977e-4935-991e-a7d0be3970a5" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_0577130f-7948-4ce4-bd5d-0f31d701cca1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherNoncashIncomeExpense"/> |
| | <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e6c860c3-7dc9-43ac-ab9c-33f89b0b0cef" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_0577130f-7948-4ce4-bd5d-0f31d701cca1" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_f23ac5d8-1d49-46c7-9338-0240900ef504" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/> |
| | <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e6c860c3-7dc9-43ac-ab9c-33f89b0b0cef" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_f23ac5d8-1d49-46c7-9338-0240900ef504" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_3b517551-f62f-4707-a639-69402115cc8b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInInventories"/> |
| | <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e6c860c3-7dc9-43ac-ab9c-33f89b0b0cef" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_3b517551-f62f-4707-a639-69402115cc8b" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_c4c0761b-f2f1-4db8-ae32-2d836d8c885a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/> |
| | <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e6c860c3-7dc9-43ac-ab9c-33f89b0b0cef" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_c4c0761b-f2f1-4db8-ae32-2d836d8c885a" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_28a78995-c80c-422f-b645-d0c9a53ad4a0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/> |
| | <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e6c860c3-7dc9-43ac-ab9c-33f89b0b0cef" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_28a78995-c80c-422f-b645-d0c9a53ad4a0" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_3c2d993e-d6e5-42dc-8837-6107f0498cfd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/> |
| | <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e6c860c3-7dc9-43ac-ab9c-33f89b0b0cef" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_3c2d993e-d6e5-42dc-8837-6107f0498cfd" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_exel_IncreaseDecreaseInAccruedCollaborationLiabilities_9edc6380-53ec-492f-b3c5-9b29264cf2ab" xlink:href="exel-20230630.xsd#exel_IncreaseDecreaseInAccruedCollaborationLiabilities"/> |
| | <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e6c860c3-7dc9-43ac-ab9c-33f89b0b0cef" xlink:to="loc_exel_IncreaseDecreaseInAccruedCollaborationLiabilities_9edc6380-53ec-492f-b3c5-9b29264cf2ab" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_7e8ac881-a628-4d72-9b72-c55e863e135d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff"/> |
| | <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e6c860c3-7dc9-43ac-ab9c-33f89b0b0cef" xlink:to="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_7e8ac881-a628-4d72-9b72-c55e863e135d" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_ac4f94b3-347b-42a3-a757-33ef87bae742" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_36fe1d0f-3e09-481e-8e3c-9cfa978606b7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_ac4f94b3-347b-42a3-a757-33ef87bae742" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_36fe1d0f-3e09-481e-8e3c-9cfa978606b7" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_4a216b38-c9ab-4653-889f-8f421d462cab" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/> |
| | <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_ac4f94b3-347b-42a3-a757-33ef87bae742" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_4a216b38-c9ab-4653-889f-8f421d462cab" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_583e4465-72ae-4f91-b22d-cb369c7cd799" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/> |
| | <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_ac4f94b3-347b-42a3-a757-33ef87bae742" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_583e4465-72ae-4f91-b22d-cb369c7cd799" xlink:type="arc"/> |
| | </link:calculationLink> |
| <link:roleRef roleURI="http://www.exelixis.com/role/RevenuesContractAssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="exel-20230630.xsd#RevenuesContractAssetsandLiabilitiesDetails"/> |
| <link:calculationLink xlink:role="http://www.exelixis.com/role/RevenuesContractAssetsandLiabilitiesDetails" xlink:type="extended"> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiability_da72f9a9-bb36-4df5-b8d1-9bfaa2ed6335" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ContractWithCustomerLiability"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_be7b255a-09fc-4835-a6ee-3e70099abdb9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ContractWithCustomerLiability_da72f9a9-bb36-4df5-b8d1-9bfaa2ed6335" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_be7b255a-09fc-4835-a6ee-3e70099abdb9" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_2154d902-dd22-44ba-84d9-9a60e6e19be2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ContractWithCustomerLiability_da72f9a9-bb36-4df5-b8d1-9bfaa2ed6335" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_2154d902-dd22-44ba-84d9-9a60e6e19be2" xlink:type="arc"/> |
| | </link:calculationLink> |
| <link:roleRef roleURI="http://www.exelixis.com/role/CashandInvestmentsInvestmentsbySecurityTypeDetails" xlink:type="simple" xlink:href="exel-20230630.xsd#CashandInvestmentsInvestmentsbySecurityTypeDetails"/> |
| <link:calculationLink xlink:role="http://www.exelixis.com/role/CashandInvestmentsInvestmentsbySecurityTypeDetails" xlink:type="extended"> |
| | <link:loc xlink:type="locator" xlink:label="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_3264f956-3e77-4fcf-934f-4f3c2fbf6bb8" xlink:href="exel-20230630.xsd#exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsGrossUnrealizedLoss_83c4d86a-7df1-4260-afbb-e39303527077" xlink:href="exel-20230630.xsd#exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsGrossUnrealizedLoss"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_3264f956-3e77-4fcf-934f-4f3c2fbf6bb8" xlink:to="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsGrossUnrealizedLoss_83c4d86a-7df1-4260-afbb-e39303527077" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_4d4fbe90-0b43-4101-afd2-2355bd02c6a1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_3264f956-3e77-4fcf-934f-4f3c2fbf6bb8" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_4d4fbe90-0b43-4101-afd2-2355bd02c6a1" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecuritiesAmortizedCostBasis_3fd4df07-6570-4526-ab3e-265b580e48dd" xlink:href="exel-20230630.xsd#exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecuritiesAmortizedCostBasis"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAmortizedCost_494c45ba-6a35-46d4-a6e9-02569d99d55c" xlink:href="exel-20230630.xsd#exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAmortizedCost"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecuritiesAmortizedCostBasis_3fd4df07-6570-4526-ab3e-265b580e48dd" xlink:to="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAmortizedCost_494c45ba-6a35-46d4-a6e9-02569d99d55c" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_b86c6877-8857-4970-b60c-ea207a68e46e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecuritiesAmortizedCostBasis_3fd4df07-6570-4526-ab3e-265b580e48dd" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_b86c6877-8857-4970-b60c-ea207a68e46e" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAmortizedCost_43a06700-0316-4634-b477-575b6f5853ba" xlink:href="exel-20230630.xsd#exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAmortizedCost"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsGrossUnrealizedGain_c7a75799-1985-4a9e-b8ae-58df7f493302" xlink:href="exel-20230630.xsd#exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsGrossUnrealizedGain"/> |
| | <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAmortizedCost_43a06700-0316-4634-b477-575b6f5853ba" xlink:to="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsGrossUnrealizedGain_c7a75799-1985-4a9e-b8ae-58df7f493302" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsFairValueDisclosure_0f404af4-996e-4a54-8cd4-f9ba24b6f312" xlink:href="exel-20230630.xsd#exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsFairValueDisclosure"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAmortizedCost_43a06700-0316-4634-b477-575b6f5853ba" xlink:to="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsFairValueDisclosure_0f404af4-996e-4a54-8cd4-f9ba24b6f312" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsGrossUnrealizedLoss_72955d7b-f693-4f16-894c-946da780bf5e" xlink:href="exel-20230630.xsd#exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsGrossUnrealizedLoss"/> |
| | <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAmortizedCost_43a06700-0316-4634-b477-575b6f5853ba" xlink:to="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsGrossUnrealizedLoss_72955d7b-f693-4f16-894c-946da780bf5e" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_f6a89878-6891-482f-a714-1f7046ceb8c8" xlink:href="exel-20230630.xsd#exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsGrossUnrealizedGain_4f36b959-9e2d-4052-b9b0-cfee2f664d21" xlink:href="exel-20230630.xsd#exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsGrossUnrealizedGain"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_f6a89878-6891-482f-a714-1f7046ceb8c8" xlink:to="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsGrossUnrealizedGain_4f36b959-9e2d-4052-b9b0-cfee2f664d21" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_968cbccd-a276-4f34-acef-b9fbe5633a15" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_f6a89878-6891-482f-a714-1f7046ceb8c8" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_968cbccd-a276-4f34-acef-b9fbe5633a15" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecurities_a90cadfc-38e5-41fb-8862-fa8ee5d47515" xlink:href="exel-20230630.xsd#exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecurities"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_459b981f-4c29-4f1f-85bf-e9e59a92a94e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecurities_a90cadfc-38e5-41fb-8862-fa8ee5d47515" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_459b981f-4c29-4f1f-85bf-e9e59a92a94e" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsFairValueDisclosure_4408fc8c-fd95-410d-9411-922a39c37240" xlink:href="exel-20230630.xsd#exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsFairValueDisclosure"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecurities_a90cadfc-38e5-41fb-8862-fa8ee5d47515" xlink:to="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsFairValueDisclosure_4408fc8c-fd95-410d-9411-922a39c37240" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_b147f152-df49-49eb-8cef-a7c4fc34a176" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_505b087c-cc7f-4041-a54b-e6a7be030509" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_b147f152-df49-49eb-8cef-a7c4fc34a176" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_505b087c-cc7f-4041-a54b-e6a7be030509" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_518425d6-0727-4d16-864e-f3bf021b2d48" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_b147f152-df49-49eb-8cef-a7c4fc34a176" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_518425d6-0727-4d16-864e-f3bf021b2d48" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_4c71207c-5916-49df-83e2-929e02c58555" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/> |
| | <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_b147f152-df49-49eb-8cef-a7c4fc34a176" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_4c71207c-5916-49df-83e2-929e02c58555" xlink:type="arc"/> |
| | </link:calculationLink> |
| <link:roleRef roleURI="http://www.exelixis.com/role/CashandInvestmentsInvestmentsbySecurityTypeDetails_1" xlink:type="simple" xlink:href="exel-20230630.xsd#CashandInvestmentsInvestmentsbySecurityTypeDetails_1"/> |
| <link:calculationLink xlink:role="http://www.exelixis.com/role/CashandInvestmentsInvestmentsbySecurityTypeDetails_1" xlink:type="extended"> |
| | <link:loc xlink:type="locator" xlink:label="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecuritiesAmortizedCostBasis_9697773f-240b-472e-95b4-052449642f5c" xlink:href="exel-20230630.xsd#exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecuritiesAmortizedCostBasis"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecurities_fcd9c3dd-b082-4038-bccc-c6338cfddada" xlink:href="exel-20230630.xsd#exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecurities"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecuritiesAmortizedCostBasis_9697773f-240b-472e-95b4-052449642f5c" xlink:to="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecurities_fcd9c3dd-b082-4038-bccc-c6338cfddada" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_fb5fe9d7-8518-4350-b138-403978bcfd80" xlink:href="exel-20230630.xsd#exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecuritiesAmortizedCostBasis_9697773f-240b-472e-95b4-052449642f5c" xlink:to="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_fb5fe9d7-8518-4350-b138-403978bcfd80" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_dd3d872f-3fdf-46f6-b951-7c365fc17008" xlink:href="exel-20230630.xsd#exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/> |
| | <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecuritiesAmortizedCostBasis_9697773f-240b-472e-95b4-052449642f5c" xlink:to="loc_exel_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAndAvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_dd3d872f-3fdf-46f6-b951-7c365fc17008" xlink:type="arc"/> |
| | </link:calculationLink> |
| <link:roleRef roleURI="http://www.exelixis.com/role/CashandInvestmentsFairValueofCashEquivalentsandInvestmentsbyContractualMaturityDetails" xlink:type="simple" xlink:href="exel-20230630.xsd#CashandInvestmentsFairValueofCashEquivalentsandInvestmentsbyContractualMaturityDetails"/> |
| <link:calculationLink xlink:role="http://www.exelixis.com/role/CashandInvestmentsFairValueofCashEquivalentsandInvestmentsbyContractualMaturityDetails" xlink:type="extended"> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_8eb25a08-7b79-49d1-94f2-944fddb1e13a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_a4838a03-9f5d-4d16-a579-e655264b8a3b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_8eb25a08-7b79-49d1-94f2-944fddb1e13a" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_a4838a03-9f5d-4d16-a579-e655264b8a3b" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_f6dac8a3-15dc-4ff4-b8fe-80cc4c13aae6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_8eb25a08-7b79-49d1-94f2-944fddb1e13a" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_f6dac8a3-15dc-4ff4-b8fe-80cc4c13aae6" xlink:type="arc"/> |
| | </link:calculationLink> |
| <link:roleRef roleURI="http://www.exelixis.com/role/FairValueMeasurementsFairValueHierarchyDetails" xlink:type="simple" xlink:href="exel-20230630.xsd#FairValueMeasurementsFairValueHierarchyDetails"/> |
| <link:calculationLink xlink:role="http://www.exelixis.com/role/FairValueMeasurementsFairValueHierarchyDetails" xlink:type="extended"> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_398168bb-9209-4000-a976-5edf683e6bec" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsFairValueDisclosure"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_2f453526-b235-4b01-b092-c0592aa382f9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_398168bb-9209-4000-a976-5edf683e6bec" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_2f453526-b235-4b01-b092-c0592aa382f9" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_add731c6-a98f-4bff-a2e4-fe728aa7a72a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_398168bb-9209-4000-a976-5edf683e6bec" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_add731c6-a98f-4bff-a2e4-fe728aa7a72a" xlink:type="arc"/> |
| | </link:calculationLink> |
| <link:roleRef roleURI="http://www.exelixis.com/role/InventoryDetails" xlink:type="simple" xlink:href="exel-20230630.xsd#InventoryDetails"/> |
| <link:calculationLink xlink:role="http://www.exelixis.com/role/InventoryDetails" xlink:type="extended"> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryGross_11b292da-b895-4559-8f5f-0d11fc137c34" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryGross"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterials_2f28da8c-2bc9-47c5-a3a4-b375914ef7db" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryRawMaterials"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryGross_11b292da-b895-4559-8f5f-0d11fc137c34" xlink:to="loc_us-gaap_InventoryRawMaterials_2f28da8c-2bc9-47c5-a3a4-b375914ef7db" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcess_fb42bb75-299a-46b0-9d55-38e8bc7e1172" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryWorkInProcess"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryGross_11b292da-b895-4559-8f5f-0d11fc137c34" xlink:to="loc_us-gaap_InventoryWorkInProcess_fb42bb75-299a-46b0-9d55-38e8bc7e1172" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoods_a1f477ea-09da-455f-9499-6210c6341430" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryFinishedGoods"/> |
| | <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryGross_11b292da-b895-4559-8f5f-0d11fc137c34" xlink:to="loc_us-gaap_InventoryFinishedGoods_a1f477ea-09da-455f-9499-6210c6341430" xlink:type="arc"/> |
| | </link:calculationLink> |
| <link:roleRef roleURI="http://www.exelixis.com/role/NetIncomePerShareComputationofBasicandDilutedNetIncomePerShareDetails" xlink:type="simple" xlink:href="exel-20230630.xsd#NetIncomePerShareComputationofBasicandDilutedNetIncomePerShareDetails"/> |
| <link:calculationLink xlink:role="http://www.exelixis.com/role/NetIncomePerShareComputationofBasicandDilutedNetIncomePerShareDetails" xlink:type="extended"> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_da3c3abb-3b6f-4735-a229-6f31aaaecb7e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_5ca6dba6-21fb-47ac-9d2d-4cd7169c6165" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/> |
| | <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_da3c3abb-3b6f-4735-a229-6f31aaaecb7e" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_5ca6dba6-21fb-47ac-9d2d-4cd7169c6165" xlink:type="arc"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_6b53401a-17c0-433f-a0f7-9b08448d8a43" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment"/> |
| | <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_da3c3abb-3b6f-4735-a229-6f31aaaecb7e" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_6b53401a-17c0-433f-a0f7-9b08448d8a43" xlink:type="arc"/> |
| | </link:calculationLink> |
| </link:linkbase> |