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AVROBIO, Inc. – ‘10-Q’ for 6/30/22 – ‘EX-101.CAL’

On:  Tuesday, 8/9/22, at 4:31pm ET   ·   For:  6/30/22   ·   Accession #:  950170-22-16117   ·   File #:  1-38537

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  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 8/09/22  AVROBIO, Inc.                     10-Q        6/30/22   65:7.3M                                   Donnelley … Solutions/FA

Quarterly Report   —   Form 10-Q

Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-Q        Quarterly Report                                    HTML   2.40M 
 2: EX-10.3     Material Contract                                   HTML    306K 
 3: EX-31.1     Certification -- §302 - SOA'02                      HTML     26K 
 4: EX-31.2     Certification -- §302 - SOA'02                      HTML     26K 
 5: EX-32.1     Certification -- §906 - SOA'02                      HTML     23K 
11: R1          Document and Entity Information                     HTML     74K 
12: R2          Condensed Consolidated Balance Sheets               HTML    100K 
13: R3          Condensed Consolidated Balance Sheets               HTML     28K 
                (Parenthetical)                                                  
14: R4          Condensed Consolidated Statements of Operations     HTML     73K 
                and Comprehensive Loss                                           
15: R5          Condensed Consolidated Statements of Stockholders'  HTML     73K 
                Equity                                                           
16: R6          Condensed Consolidated Statements of Stockholders'  HTML     22K 
                Equity (Parenthetical)                                           
17: R7          Condensed Consolidated Statements of Cash Flows     HTML     98K 
18: R8          Nature of the Business                              HTML     28K 
19: R9          Summary of Significant Accounting Policies          HTML     50K 
20: R10         License Agreements                                  HTML     65K 
21: R11         Fair Value Measurement                              HTML     82K 
22: R12         Supplemental Balance Sheet Information              HTML    105K 
23: R13         Commitments and Contingencies                       HTML     27K 
24: R14         Note Payable                                        HTML     67K 
25: R15         Stockholders' Equity                                HTML     62K 
26: R16         Stock-Based Compensation                            HTML    154K 
27: R17         Net Loss Per Share                                  HTML     36K 
28: R18         Related Party Transactions                          HTML     30K 
29: R19         Restructuring Activities                            HTML     41K 
30: R20         Summary of Significant Accounting Policies          HTML     63K 
                (Policies)                                                       
31: R21         Fair Value Measurement (Tables)                     HTML     80K 
32: R22         Supplemental Balance Sheet Information (Tables)     HTML    102K 
33: R23         Note Payable (Tables)                               HTML     49K 
34: R24         Stockholders' Equity (Tables)                       HTML     56K 
35: R25         Stock-Based Compensation (Tables)                   HTML    149K 
36: R26         Net Loss Per Share (Tables)                         HTML     34K 
37: R27         Restructuring Activities (Tables)                   HTML     34K 
38: R28         Nature of the Business - Additional Information     HTML     38K 
                (Detail)                                                         
39: R29         Summary of Significant Accounting Policies -        HTML     22K 
                Additional Information (Detail)                                  
40: R30         License Agreements - Additional Information         HTML     93K 
                (Detail)                                                         
41: R31         Fair Value Measurement - Summary of Financial       HTML     29K 
                Assets Measured at Fair Value on Recurring Basis                 
                (Detail)                                                         
42: R32         Fair Value Measurement - Additional Information     HTML     21K 
                (Detail)                                                         
43: R33         Supplemental Balance Sheet Information - Summary    HTML     32K 
                of Prepaid Expenses and Other Current Assets                     
                (Detail)                                                         
44: R34         Supplemental Balance Sheet Information - Summary    HTML     34K 
                of Property and Equipment, Net (Detail)                          
45: R35         Supplemental Balance Sheet Information -            HTML     25K 
                Additional Information (Detail)                                  
46: R36         Supplemental Balance Sheet Information - Summary    HTML     30K 
                of Accrued Expenses (Detail)                                     
47: R37         Note Payable - Additional Information (Details)     HTML     70K 
48: R38         Note Payable - Carrying Value of Note Payable       HTML     26K 
                (Details)                                                        
49: R39         Note Payable - Future Principal Payments (Details)  HTML     31K 
50: R40         Stockholders' Equity - Additional Information       HTML     29K 
                (Detail)                                                         
51: R41         Stockholders' Equity - Summary of Common Stock      HTML     35K 
                Reserved for Future Issuance (Detail)                            
52: R42         Stock-Based Compensation - Summary of Assumptions   HTML     27K 
                that Used to Determine Grant-Date Fair Value of                  
                Stock Options Granted to Employees and Members of                
                Board of Directors (Detail)                                      
53: R43         Stock-Based Compensation - Summary of Stock Option  HTML     53K 
                Activity (Detail)                                                
54: R44         Stock-Based Compensation - Additional Information   HTML     35K 
                (Detail)                                                         
55: R45         Stock-Based Compensation - Summary of Restricted    HTML     42K 
                Common Stock Units (Detail)                                      
56: R46         Stock-Based Compensation - Schedule of Stock-based  HTML     27K 
                Compensation Expense (Detail)                                    
57: R47         Net Loss Per Share - Schedule of Dilutive Common    HTML     26K 
                Stock Equivalents Excluded from Computation of                   
                Diluted Net Loss per Share (Detail)                              
58: R48         Related Party Transactions - Additional             HTML     31K 
                Information (Detail)                                             
59: R49         Restructuring Activities - Additional Information   HTML     32K 
                (Detail)                                                         
60: R50         Restructuring Activities - Summary of Charges       HTML     29K 
                Related to Restructuring Activities (Detail)                     
63: XML         IDEA XML File -- Filing Summary                      XML    115K 
61: XML         XBRL Instance -- avro-20220630_htm                   XML   1.42M 
62: EXCEL       IDEA Workbook of Financial Reports                  XLSX    103K 
 6: EX-101.CAL  XBRL Calculations -- avro-20220630_cal               XML     97K 
 7: EX-101.DEF  XBRL Definitions -- avro-20220630_def                XML    321K 
 8: EX-101.LAB  XBRL Labels -- avro-20220630_lab                     XML    876K 
 9: EX-101.PRE  XBRL Presentations -- avro-20220630_pre              XML    594K 
10: EX-101.SCH  XBRL Schema -- avro-20220630                         XSD    128K 
64: JSON        XBRL Instance as JSON Data -- MetaLinks              271±   426K 
65: ZIP         XBRL Zipped Folder -- 0000950170-22-016117-xbrl      Zip    382K 


‘EX-101.CAL’   —   XBRL Calculations — avro-20220630_cal


This Exhibit is an XBRL XML File.


                                                                                                                                                                                
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<!-- DFIN New ActiveDisclosure (SM) XBRL Linkbase Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date :2022-08-09T10:49:44.2288+00:00 -->
<!-- Copyright (c) 2022 Donnelly Financial Solutions, Inc. All Rights Reserved. -->
<link:linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<link:roleRef roleURI="http://www.avrobio.com/20220630/taxonomy/role/Role_StatementCondensedConsolidatedBalanceSheets" xlink:href="avro-20220630.xsd#Role_StatementCondensedConsolidatedBalanceSheets" xlink:type="simple"/>
<link:roleRef roleURI="http://www.avrobio.com/20220630/taxonomy/role/Role_StatementCondensedConsolidatedStatementsOfOperationsAndComprehensiveLoss" xlink:href="avro-20220630.xsd#Role_StatementCondensedConsolidatedStatementsOfOperationsAndComprehensiveLoss" xlink:type="simple"/>
<link:roleRef roleURI="http://www.avrobio.com/20220630/taxonomy/role/Role_StatementCondensedConsolidatedStatementsOfCashFlows" xlink:href="avro-20220630.xsd#Role_StatementCondensedConsolidatedStatementsOfCashFlows" xlink:type="simple"/>
<link:roleRef roleURI="http://www.avrobio.com/20220630/taxonomy/role/Role_DisclosureSupplementalBalanceSheetInformationSummaryOfPrepaidExpensesAndOtherCurrentAssetsDetail" xlink:href="avro-20220630.xsd#Role_DisclosureSupplementalBalanceSheetInformationSummaryOfPrepaidExpensesAndOtherCurrentAssetsDetail" xlink:type="simple"/>
<link:roleRef roleURI="http://www.avrobio.com/20220630/taxonomy/role/Role_DisclosureSupplementalBalanceSheetInformationSummaryOfPropertyAndEquipmentNetDetail" xlink:href="avro-20220630.xsd#Role_DisclosureSupplementalBalanceSheetInformationSummaryOfPropertyAndEquipmentNetDetail" xlink:type="simple"/>
<link:roleRef roleURI="http://www.avrobio.com/20220630/taxonomy/role/Role_DisclosureSupplementalBalanceSheetInformationSummaryOfAccruedExpensesDetail" xlink:href="avro-20220630.xsd#Role_DisclosureSupplementalBalanceSheetInformationSummaryOfAccruedExpensesDetail" xlink:type="simple"/>
<link:roleRef roleURI="http://www.avrobio.com/20220630/taxonomy/role/Role_DisclosureNotePayableCarryingValueOfNotePayableDetails" xlink:href="avro-20220630.xsd#Role_DisclosureNotePayableCarryingValueOfNotePayableDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://www.avrobio.com/20220630/taxonomy/role/Role_DisclosureNotePayableFuturePrincipalPaymentsDetails" xlink:href="avro-20220630.xsd#Role_DisclosureNotePayableFuturePrincipalPaymentsDetails" xlink:type="simple"/>
<link:calculationLink xlink:type="extended" xlink:role="http://www.avrobio.com/20220630/taxonomy/role/Role_StatementCondensedConsolidatedBalanceSheets">
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent" xlink:to="us-gaap_AccountsPayableCurrent" order="0" weight="1.00" use="optional"/>
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_Liabilities" xlink:to="us-gaap_LiabilitiesCurrent" order="0" weight="1.00" use="optional"/>
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesAndStockholdersEquity" xlink:to="us-gaap_Liabilities" order="0" weight="1.00" use="optional"/>
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_AssetsCurrent" xlink:to="us-gaap_CashAndCashEquivalentsAtCarryingValue" order="0" weight="1.00" use="optional"/>
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_Assets" xlink:to="us-gaap_AssetsCurrent" order="0" weight="1.00" use="optional"/>
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_StockholdersEquity" xlink:to="us-gaap_CommonStockValue" order="0" weight="1.00" use="optional"/>
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_Liabilities" xlink:to="us-gaap_LongTermNotesPayable" order="1" weight="1.00" use="optional"/>
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_Assets" xlink:to="us-gaap_PropertyPlantAndEquipmentNet" order="1" weight="1.00" use="optional"/>
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent" xlink:to="us-gaap_AccruedLiabilitiesCurrent" order="1" weight="1.00" use="optional"/>
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_AssetsCurrent" xlink:to="us-gaap_PrepaidExpenseAndOtherAssetsCurrent" order="1" weight="1.00" use="optional"/>
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_StockholdersEquity" xlink:to="us-gaap_AdditionalPaidInCapitalCommonStock" order="1" weight="1.00" use="optional"/>
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesAndStockholdersEquity" xlink:to="us-gaap_CommitmentsAndContingencies" order="1" weight="1.00" use="optional"/>
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent" xlink:to="us-gaap_DeferredRentCreditCurrent" order="2" weight="1.00" use="optional"/>
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesAndStockholdersEquity" xlink:to="us-gaap_StockholdersEquity" order="2" weight="1.00" use="optional"/>
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_Liabilities" xlink:to="us-gaap_DeferredRentCreditNoncurrent" order="2" weight="1.00" use="optional"/>
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_StockholdersEquity" xlink:to="us-gaap_RetainedEarningsAccumulatedDeficit" order="2" weight="1.00" use="optional"/>
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_Assets" xlink:to="us-gaap_RestrictedCashNoncurrent" order="2" weight="1.00" use="optional"/>
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_Assets" xlink:to="us-gaap_OtherAssetsNoncurrent" order="3" weight="1.00" use="optional"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrent" xlink:label="us-gaap_LiabilitiesCurrent"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableCurrent" xlink:label="us-gaap_AccountsPayableCurrent"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities" xlink:label="us-gaap_Liabilities"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="us-gaap_LiabilitiesAndStockholdersEquity"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent" xlink:label="us-gaap_AssetsCurrent"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Assets" xlink:label="us-gaap_Assets"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity" xlink:label="us-gaap_StockholdersEquity"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockValue" xlink:label="us-gaap_CommonStockValue"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermNotesPayable" xlink:label="us-gaap_LongTermNotesPayable"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="us-gaap_PropertyPlantAndEquipmentNet"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesCurrent" xlink:label="us-gaap_AccruedLiabilitiesCurrent"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:label="us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapitalCommonStock" xlink:label="us-gaap_AdditionalPaidInCapitalCommonStock"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingencies" xlink:label="us-gaap_CommitmentsAndContingencies"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredRentCreditCurrent" xlink:label="us-gaap_DeferredRentCreditCurrent"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredRentCreditNoncurrent" xlink:label="us-gaap_DeferredRentCreditNoncurrent"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="us-gaap_RetainedEarningsAccumulatedDeficit"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashNoncurrent" xlink:label="us-gaap_RestrictedCashNoncurrent"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsNoncurrent" xlink:label="us-gaap_OtherAssetsNoncurrent"/>
</link:calculationLink>
<link:calculationLink xlink:type="extended" xlink:role="http://www.avrobio.com/20220630/taxonomy/role/Role_StatementCondensedConsolidatedStatementsOfOperationsAndComprehensiveLoss">
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_OperatingExpenses" xlink:to="us-gaap_ResearchAndDevelopmentExpense" order="0" weight="1.00" use="optional"/>
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_OperatingIncomeLoss" xlink:to="us-gaap_OperatingExpenses" order="0" weight="-1.00" use="optional"/>
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NonoperatingIncomeExpense" xlink:to="us-gaap_InvestmentIncomeNet" order="0" weight="1.00" use="optional"/>
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetIncomeLoss" xlink:to="us-gaap_OperatingIncomeLoss" order="0" weight="1.00" use="optional"/>
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NonoperatingIncomeExpense" xlink:to="us-gaap_OtherNonoperatingIncomeExpense" order="1" weight="1" use="optional"/>
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetIncomeLoss" xlink:to="us-gaap_NonoperatingIncomeExpense" order="1" weight="1.00" use="optional"/>
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_OperatingExpenses" xlink:to="us-gaap_GeneralAndAdministrativeExpense" order="1" weight="1.00" use="optional"/>
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<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="us-gaap_ResearchAndDevelopmentExpense"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss" xlink:label="us-gaap_OperatingIncomeLoss"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="us-gaap_NonoperatingIncomeExpense"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentIncomeNet" xlink:label="us-gaap_InvestmentIncomeNet"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss" xlink:label="us-gaap_NetIncomeLoss"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="us-gaap_OtherNonoperatingIncomeExpense"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GeneralAndAdministrativeExpense" xlink:label="us-gaap_GeneralAndAdministrativeExpense"/>
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<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:to="us-gaap_NetCashProvidedByUsedInOperatingActivities" order="0" weight="1.00" use="optional"/>
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:to="us-gaap_ProceedsFromStockOptionsExercised" order="0" weight="1.00" use="optional"/>
<link:calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:to="us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" order="0" weight="-1.00" use="optional"/>
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7 Subsequent Filings that Reference this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 4/29/24  AVROBIO, Inc.                     S-4/A                 80:15M                                    Donnelley … Solutions/FA
 4/15/24  AVROBIO, Inc.                     S-4/A                 91:17M                                    Donnelley … Solutions/FA
 3/26/24  AVROBIO, Inc.                     S-4/A       3/25/24   89:18M                                    Donnelley … Solutions/FA
 3/14/24  AVROBIO, Inc.                     10-K       12/31/23   80:9.4M                                   Donnelley … Solutions/FA
 2/14/24  AVROBIO, Inc.                     S-4                   91:25M                                    Donnelley … Solutions/FA
 3/23/23  AVROBIO, Inc.                     10-K       12/31/22   82:10M                                    Donnelley … Solutions/FA
11/08/22  AVROBIO, Inc.                     S-3                    8:1.8M                                   Broadridge Fin’l So… Inc


4 Previous Filings that this Filing References

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 6/10/22  AVROBIO, Inc.                     8-K:5,9     6/08/22   11:205K                                   ActiveDisclosure/FA
 5/10/22  AVROBIO, Inc.                     10-Q        3/31/22   64:5.9M                                   ActiveDisclosure/FA
11/05/20  AVROBIO, Inc.                     10-Q        9/30/20   61:6.1M                                   ActiveDisclosure/FA
 6/25/18  AVROBIO, Inc.                     8-K:5,9     6/20/18    3:148K                                   Donnelley … Solutions/FA
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