| | | | | | | | | | | | | | | | | | | | | |
<?xml version="1.0" encoding="windows-1252"?> |
<xbrl xml:lang="en-US" xmlns="http://www.xbrl.org/2003/instance" xmlns:dei="http://xbrl.sec.gov/dei/2021" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink"> |
| <link:schemaRef xlink:href="tvst-20220907.xsd" xlink:type="simple"/> |
| <context id="i1a5745c5f2984951811622a3bfc80473_D20220907-20220907"> |
| | <entity> |
| | | <identifier scheme="http://www.sec.gov/CIK"> 0001860782 </identifier> |
| | | </entity> |
| | <period> |
| | | <startDate> 2022-09-07 </startDate> |
| | | <endDate> 2022-09-07 </endDate> |
| | | </period> |
| | </context> |
| <dei:EntityCentralIndexKey contextRef="i1a5745c5f2984951811622a3bfc80473_D20220907-20220907" id="id3VybDovL2RvY3MudjEvZG9jOmYzNzJjYTE4ODdjMzRhMGI5OTgxMjQ4ODlmNmYyYjZjL3NlYzpmMzcyY2ExODg3YzM0YTBiOTk4MTI0ODg5ZjZmMmI2Y180L2ZyYWc6N2VhZjg2N2U1Y2VmNGJmOWI5ZjA3N2FhZTdiYjBhODQvdGFibGU6ZjgyYWEyMzhjNmIyNDM0NmJjYjA3ZGM0N2VhNTJjOTkvdGFibGVyYW5nZTpmODJhYTIzOGM2YjI0MzQ2YmNiMDdkYzQ3ZWE1MmM5OV8wLTEtMS0xLTY2NjQw_7c088d4e-27ee-40c7-b0e3-72f0c0b04a33"> 0001860782 </dei:EntityCentralIndexKey> |
| <dei:AmendmentFlag contextRef="i1a5745c5f2984951811622a3bfc80473_D20220907-20220907" id="id3VybDovL2RvY3MudjEvZG9jOmYzNzJjYTE4ODdjMzRhMGI5OTgxMjQ4ODlmNmYyYjZjL3NlYzpmMzcyY2ExODg3YzM0YTBiOTk4MTI0ODg5ZjZmMmI2Y180L2ZyYWc6N2VhZjg2N2U1Y2VmNGJmOWI5ZjA3N2FhZTdiYjBhODQvdGFibGU6ZjgyYWEyMzhjNmIyNDM0NmJjYjA3ZGM0N2VhNTJjOTkvdGFibGVyYW5nZTpmODJhYTIzOGM2YjI0MzQ2YmNiMDdkYzQ3ZWE1MmM5OV8xLTEtMS0xLTY2NjQw_ad72b46c-4a23-4693-ba50-a5c39936e879"> false </dei:AmendmentFlag> |
| <dei:DocumentType contextRef="i1a5745c5f2984951811622a3bfc80473_D20220907-20220907" id="id3VybDovL2RvY3MudjEvZG9jOmYzNzJjYTE4ODdjMzRhMGI5OTgxMjQ4ODlmNmYyYjZjL3NlYzpmMzcyY2ExODg3YzM0YTBiOTk4MTI0ODg5ZjZmMmI2Y18xL2ZyYWc6ODNjMjk3YTc5MjE2NDViYWI0ZTljZTMxNmY5MjBiYmIvdGV4dHJlZ2lvbjo4M2MyOTdhNzkyMTY0NWJhYjRlOWNlMzE2ZjkyMGJiYl8xMzIz_ceeb4339-4cb5-43ca-82ef-16c1d5042412"> 8-K </dei:DocumentType> |
| <dei:DocumentPeriodEndDate contextRef="i1a5745c5f2984951811622a3bfc80473_D20220907-20220907" id="id3VybDovL2RvY3MudjEvZG9jOmYzNzJjYTE4ODdjMzRhMGI5OTgxMjQ4ODlmNmYyYjZjL3NlYzpmMzcyY2ExODg3YzM0YTBiOTk4MTI0ODg5ZjZmMmI2Y18xL2ZyYWc6ODNjMjk3YTc5MjE2NDViYWI0ZTljZTMxNmY5MjBiYmIvdGV4dHJlZ2lvbjo4M2MyOTdhNzkyMTY0NWJhYjRlOWNlMzE2ZjkyMGJiYl8yNzY_01ca100c-e73d-4fbb-9fda-80f9cedddb56"> 2022-09-07 </dei:DocumentPeriodEndDate> |
| <dei:EntityRegistrantName contextRef="i1a5745c5f2984951811622a3bfc80473_D20220907-20220907" id="id3VybDovL2RvY3MudjEvZG9jOmYzNzJjYTE4ODdjMzRhMGI5OTgxMjQ4ODlmNmYyYjZjL3NlYzpmMzcyY2ExODg3YzM0YTBiOTk4MTI0ODg5ZjZmMmI2Y18xL2ZyYWc6ODNjMjk3YTc5MjE2NDViYWI0ZTljZTMxNmY5MjBiYmIvdGV4dHJlZ2lvbjo4M2MyOTdhNzkyMTY0NWJhYjRlOWNlMzE2ZjkyMGJiYl8xMzI0_27eb0c9f-d84c-4b2e-b8e2-ac18a37cbe4d"> 2seventy bio, Inc. </dei:EntityRegistrantName> |
| <dei:EntityIncorporationStateCountryCode contextRef="i1a5745c5f2984951811622a3bfc80473_D20220907-20220907" id="id3VybDovL2RvY3MudjEvZG9jOmYzNzJjYTE4ODdjMzRhMGI5OTgxMjQ4ODlmNmYyYjZjL3NlYzpmMzcyY2ExODg3YzM0YTBiOTk4MTI0ODg5ZjZmMmI2Y18xL2ZyYWc6ODNjMjk3YTc5MjE2NDViYWI0ZTljZTMxNmY5MjBiYmIvdGFibGU6ZGZiMmIwNTNmZDVlNGQzYmJkMTk1NGMzMWEwOWE1YzEvdGFibGVyYW5nZTpkZmIyYjA1M2ZkNWU0ZDNiYmQxOTU0YzMxYTA5YTVjMV8wLTAtMS0xLTY2NjQw_ed2b1d66-bd8c-4f7e-a9c5-3658825de1b4"> DE </dei:EntityIncorporationStateCountryCode> |
| <dei:EntityFileNumber contextRef="i1a5745c5f2984951811622a3bfc80473_D20220907-20220907" id="id3VybDovL2RvY3MudjEvZG9jOmYzNzJjYTE4ODdjMzRhMGI5OTgxMjQ4ODlmNmYyYjZjL3NlYzpmMzcyY2ExODg3YzM0YTBiOTk4MTI0ODg5ZjZmMmI2Y18xL2ZyYWc6ODNjMjk3YTc5MjE2NDViYWI0ZTljZTMxNmY5MjBiYmIvdGFibGU6ZGZiMmIwNTNmZDVlNGQzYmJkMTk1NGMzMWEwOWE1YzEvdGFibGVyYW5nZTpkZmIyYjA1M2ZkNWU0ZDNiYmQxOTU0YzMxYTA5YTVjMV8wLTEtMS0xLTY2NjQw_4f302b9f-44b6-41bf-bf4e-83664c1ad24d"> 001-40791 </dei:EntityFileNumber> |
| <dei:EntityTaxIdentificationNumber contextRef="i1a5745c5f2984951811622a3bfc80473_D20220907-20220907" id="id3VybDovL2RvY3MudjEvZG9jOmYzNzJjYTE4ODdjMzRhMGI5OTgxMjQ4ODlmNmYyYjZjL3NlYzpmMzcyY2ExODg3YzM0YTBiOTk4MTI0ODg5ZjZmMmI2Y18xL2ZyYWc6ODNjMjk3YTc5MjE2NDViYWI0ZTljZTMxNmY5MjBiYmIvdGFibGU6ZGZiMmIwNTNmZDVlNGQzYmJkMTk1NGMzMWEwOWE1YzEvdGFibGVyYW5nZTpkZmIyYjA1M2ZkNWU0ZDNiYmQxOTU0YzMxYTA5YTVjMV8wLTItMS0xLTY2NjQw_305e81e5-6c4e-4aa9-b1ce-c8f60c26e1d6"> 86-3658454 </dei:EntityTaxIdentificationNumber> |
| <dei:EntityAddressAddressLine1 contextRef="i1a5745c5f2984951811622a3bfc80473_D20220907-20220907" id="id3VybDovL2RvY3MudjEvZG9jOmYzNzJjYTE4ODdjMzRhMGI5OTgxMjQ4ODlmNmYyYjZjL3NlYzpmMzcyY2ExODg3YzM0YTBiOTk4MTI0ODg5ZjZmMmI2Y18xL2ZyYWc6ODNjMjk3YTc5MjE2NDViYWI0ZTljZTMxNmY5MjBiYmIvdGFibGU6ZGZiMmIwNTNmZDVlNGQzYmJkMTk1NGMzMWEwOWE1YzEvdGFibGVyYW5nZTpkZmIyYjA1M2ZkNWU0ZDNiYmQxOTU0YzMxYTA5YTVjMV8zLTAtMS0xLTY2NjQw_c1e2ca4c-fc7b-4376-aa08-811f0a208314"> 60 Binney Street, </dei:EntityAddressAddressLine1> |
| <dei:EntityAddressPostalZipCode contextRef="i1a5745c5f2984951811622a3bfc80473_D20220907-20220907" id="id3VybDovL2RvY3MudjEvZG9jOmYzNzJjYTE4ODdjMzRhMGI5OTgxMjQ4ODlmNmYyYjZjL3NlYzpmMzcyY2ExODg3YzM0YTBiOTk4MTI0ODg5ZjZmMmI2Y18xL2ZyYWc6ODNjMjk3YTc5MjE2NDViYWI0ZTljZTMxNmY5MjBiYmIvdGFibGU6ZGZiMmIwNTNmZDVlNGQzYmJkMTk1NGMzMWEwOWE1YzEvdGFibGVyYW5nZTpkZmIyYjA1M2ZkNWU0ZDNiYmQxOTU0YzMxYTA5YTVjMV8zLTItMS0xLTY2NjQw_56cf4e74-e902-4841-a8b4-e08cc99a32b5"> 02142 </dei:EntityAddressPostalZipCode> |
| <dei:EntityAddressCityOrTown contextRef="i1a5745c5f2984951811622a3bfc80473_D20220907-20220907" id="id3VybDovL2RvY3MudjEvZG9jOmYzNzJjYTE4ODdjMzRhMGI5OTgxMjQ4ODlmNmYyYjZjL3NlYzpmMzcyY2ExODg3YzM0YTBiOTk4MTI0ODg5ZjZmMmI2Y18xL2ZyYWc6ODNjMjk3YTc5MjE2NDViYWI0ZTljZTMxNmY5MjBiYmIvdGFibGU6ZGZiMmIwNTNmZDVlNGQzYmJkMTk1NGMzMWEwOWE1YzEvdGFibGVyYW5nZTpkZmIyYjA1M2ZkNWU0ZDNiYmQxOTU0YzMxYTA5YTVjMV80LTAtMS0xLTY2NjQwL3RleHRyZWdpb246ZTZlMWFmNmQ3NjAzNDYzNDlkYjQyNDRlZTY5MGJhNjJfNA_31e731ba-2ae2-49c0-8745-949938d93015"> Cambridge </dei:EntityAddressCityOrTown> |
| <dei:EntityAddressStateOrProvince contextRef="i1a5745c5f2984951811622a3bfc80473_D20220907-20220907" id="id3VybDovL2RvY3MudjEvZG9jOmYzNzJjYTE4ODdjMzRhMGI5OTgxMjQ4ODlmNmYyYjZjL3NlYzpmMzcyY2ExODg3YzM0YTBiOTk4MTI0ODg5ZjZmMmI2Y18xL2ZyYWc6ODNjMjk3YTc5MjE2NDViYWI0ZTljZTMxNmY5MjBiYmIvdGFibGU6ZGZiMmIwNTNmZDVlNGQzYmJkMTk1NGMzMWEwOWE1YzEvdGFibGVyYW5nZTpkZmIyYjA1M2ZkNWU0ZDNiYmQxOTU0YzMxYTA5YTVjMV80LTAtMS0xLTY2NjQwL3RleHRyZWdpb246ZTZlMWFmNmQ3NjAzNDYzNDlkYjQyNDRlZTY5MGJhNjJfOA_b961dfce-3389-473d-81fe-b702d81f24be"> MA </dei:EntityAddressStateOrProvince> |
| <dei:CityAreaCode contextRef="i1a5745c5f2984951811622a3bfc80473_D20220907-20220907" id="id3VybDovL2RvY3MudjEvZG9jOmYzNzJjYTE4ODdjMzRhMGI5OTgxMjQ4ODlmNmYyYjZjL3NlYzpmMzcyY2ExODg3YzM0YTBiOTk4MTI0ODg5ZjZmMmI2Y18xL2ZyYWc6ODNjMjk3YTc5MjE2NDViYWI0ZTljZTMxNmY5MjBiYmIvdGV4dHJlZ2lvbjo4M2MyOTdhNzkyMTY0NWJhYjRlOWNlMzE2ZjkyMGJiYl8xMzI1_d9cbe9ae-990d-4356-8c8c-97d812bc1e6b"> 339 </dei:CityAreaCode> |
| <dei:LocalPhoneNumber contextRef="i1a5745c5f2984951811622a3bfc80473_D20220907-20220907" id="id3VybDovL2RvY3MudjEvZG9jOmYzNzJjYTE4ODdjMzRhMGI5OTgxMjQ4ODlmNmYyYjZjL3NlYzpmMzcyY2ExODg3YzM0YTBiOTk4MTI0ODg5ZjZmMmI2Y18xL2ZyYWc6ODNjMjk3YTc5MjE2NDViYWI0ZTljZTMxNmY5MjBiYmIvdGV4dHJlZ2lvbjo4M2MyOTdhNzkyMTY0NWJhYjRlOWNlMzE2ZjkyMGJiYl8xMzI2_669483cd-5b7c-49dd-8edf-1abd6973012b"> 499-9300 </dei:LocalPhoneNumber> |
| <dei:WrittenCommunications contextRef="i1a5745c5f2984951811622a3bfc80473_D20220907-20220907" id="id3VybDovL2RvY3MudjEvZG9jOmYzNzJjYTE4ODdjMzRhMGI5OTgxMjQ4ODlmNmYyYjZjL3NlYzpmMzcyY2ExODg3YzM0YTBiOTk4MTI0ODg5ZjZmMmI2Y18xL2ZyYWc6ODNjMjk3YTc5MjE2NDViYWI0ZTljZTMxNmY5MjBiYmIvdGFibGU6YmY2NmJjMzllYWNiNDVhOTkwNmY5MTc2YTAwZDg1ZGQvdGFibGVyYW5nZTpiZjY2YmMzOWVhY2I0NWE5OTA2ZjkxNzZhMDBkODVkZF8wLTAtMS0xLTY2NjQw_45500bff-9277-43ca-870f-0145a004843c"> false </dei:WrittenCommunications> |
| <dei:SolicitingMaterial contextRef="i1a5745c5f2984951811622a3bfc80473_D20220907-20220907" id="id3VybDovL2RvY3MudjEvZG9jOmYzNzJjYTE4ODdjMzRhMGI5OTgxMjQ4ODlmNmYyYjZjL3NlYzpmMzcyY2ExODg3YzM0YTBiOTk4MTI0ODg5ZjZmMmI2Y18xL2ZyYWc6ODNjMjk3YTc5MjE2NDViYWI0ZTljZTMxNmY5MjBiYmIvdGFibGU6YmY2NmJjMzllYWNiNDVhOTkwNmY5MTc2YTAwZDg1ZGQvdGFibGVyYW5nZTpiZjY2YmMzOWVhY2I0NWE5OTA2ZjkxNzZhMDBkODVkZF8yLTAtMS0xLTY2NjQw_02b8e8c1-d93c-4866-9e8d-9fdeae393c32"> false </dei:SolicitingMaterial> |
| <dei:PreCommencementTenderOffer contextRef="i1a5745c5f2984951811622a3bfc80473_D20220907-20220907" id="id3VybDovL2RvY3MudjEvZG9jOmYzNzJjYTE4ODdjMzRhMGI5OTgxMjQ4ODlmNmYyYjZjL3NlYzpmMzcyY2ExODg3YzM0YTBiOTk4MTI0ODg5ZjZmMmI2Y18xL2ZyYWc6ODNjMjk3YTc5MjE2NDViYWI0ZTljZTMxNmY5MjBiYmIvdGFibGU6YmY2NmJjMzllYWNiNDVhOTkwNmY5MTc2YTAwZDg1ZGQvdGFibGVyYW5nZTpiZjY2YmMzOWVhY2I0NWE5OTA2ZjkxNzZhMDBkODVkZF80LTAtMS0xLTY2NjQw_105c33c5-5b7f-4133-b72b-41f1e74414c4"> false </dei:PreCommencementTenderOffer> |
| <dei:PreCommencementIssuerTenderOffer contextRef="i1a5745c5f2984951811622a3bfc80473_D20220907-20220907" id="id3VybDovL2RvY3MudjEvZG9jOmYzNzJjYTE4ODdjMzRhMGI5OTgxMjQ4ODlmNmYyYjZjL3NlYzpmMzcyY2ExODg3YzM0YTBiOTk4MTI0ODg5ZjZmMmI2Y18xL2ZyYWc6ODNjMjk3YTc5MjE2NDViYWI0ZTljZTMxNmY5MjBiYmIvdGFibGU6YmY2NmJjMzllYWNiNDVhOTkwNmY5MTc2YTAwZDg1ZGQvdGFibGVyYW5nZTpiZjY2YmMzOWVhY2I0NWE5OTA2ZjkxNzZhMDBkODVkZF82LTAtMS0xLTY2NjQw_c95e97c3-dd4a-452d-b50c-4f691807a9ca"> false </dei:PreCommencementIssuerTenderOffer> |
| <dei:Security12bTitle contextRef="i1a5745c5f2984951811622a3bfc80473_D20220907-20220907" id="id3VybDovL2RvY3MudjEvZG9jOmYzNzJjYTE4ODdjMzRhMGI5OTgxMjQ4ODlmNmYyYjZjL3NlYzpmMzcyY2ExODg3YzM0YTBiOTk4MTI0ODg5ZjZmMmI2Y18xL2ZyYWc6ODNjMjk3YTc5MjE2NDViYWI0ZTljZTMxNmY5MjBiYmIvdGFibGU6M2QzNmRlYmZhMmZhNDE4OTg0YjFmZjRkNzMzODFlYTcvdGFibGVyYW5nZTozZDM2ZGViZmEyZmE0MTg5ODRiMWZmNGQ3MzM4MWVhN18xLTAtMS0xLTY2NjQw_f9cc1099-27b3-4e29-a51b-c92cedf80fa2"> Common Stock, $0.0001 par value per share </dei:Security12bTitle> |
| <dei:TradingSymbol contextRef="i1a5745c5f2984951811622a3bfc80473_D20220907-20220907" id="id3VybDovL2RvY3MudjEvZG9jOmYzNzJjYTE4ODdjMzRhMGI5OTgxMjQ4ODlmNmYyYjZjL3NlYzpmMzcyY2ExODg3YzM0YTBiOTk4MTI0ODg5ZjZmMmI2Y18xL2ZyYWc6ODNjMjk3YTc5MjE2NDViYWI0ZTljZTMxNmY5MjBiYmIvdGFibGU6M2QzNmRlYmZhMmZhNDE4OTg0YjFmZjRkNzMzODFlYTcvdGFibGVyYW5nZTozZDM2ZGViZmEyZmE0MTg5ODRiMWZmNGQ3MzM4MWVhN18xLTEtMS0xLTY2NjQw_7c506a9b-8bed-4778-b02f-070f85b715b5"> TSVT </dei:TradingSymbol> |
| <dei:SecurityExchangeName contextRef="i1a5745c5f2984951811622a3bfc80473_D20220907-20220907" id="id3VybDovL2RvY3MudjEvZG9jOmYzNzJjYTE4ODdjMzRhMGI5OTgxMjQ4ODlmNmYyYjZjL3NlYzpmMzcyY2ExODg3YzM0YTBiOTk4MTI0ODg5ZjZmMmI2Y18xL2ZyYWc6ODNjMjk3YTc5MjE2NDViYWI0ZTljZTMxNmY5MjBiYmIvdGFibGU6M2QzNmRlYmZhMmZhNDE4OTg0YjFmZjRkNzMzODFlYTcvdGFibGVyYW5nZTozZDM2ZGViZmEyZmE0MTg5ODRiMWZmNGQ3MzM4MWVhN18xLTItMS0xLTY2NjQw_ceccb804-abbf-4491-9eb7-ca1598da8d48"> NASDAQ </dei:SecurityExchangeName> |
| <dei:EntityEmergingGrowthCompany contextRef="i1a5745c5f2984951811622a3bfc80473_D20220907-20220907" id="id3VybDovL2RvY3MudjEvZG9jOmYzNzJjYTE4ODdjMzRhMGI5OTgxMjQ4ODlmNmYyYjZjL3NlYzpmMzcyY2ExODg3YzM0YTBiOTk4MTI0ODg5ZjZmMmI2Y18xL2ZyYWc6ODNjMjk3YTc5MjE2NDViYWI0ZTljZTMxNmY5MjBiYmIvdGV4dHJlZ2lvbjo4M2MyOTdhNzkyMTY0NWJhYjRlOWNlMzE2ZjkyMGJiYl8xMzI3_fdb9c0a1-14a6-4f0f-9608-942a1a8774fb"> true </dei:EntityEmergingGrowthCompany> |
| <dei:EntityExTransitionPeriod contextRef="i1a5745c5f2984951811622a3bfc80473_D20220907-20220907" id="id3VybDovL2RvY3MudjEvZG9jOmYzNzJjYTE4ODdjMzRhMGI5OTgxMjQ4ODlmNmYyYjZjL3NlYzpmMzcyY2ExODg3YzM0YTBiOTk4MTI0ODg5ZjZmMmI2Y18xL2ZyYWc6ODNjMjk3YTc5MjE2NDViYWI0ZTljZTMxNmY5MjBiYmIvdGV4dHJlZ2lvbjo4M2MyOTdhNzkyMTY0NWJhYjRlOWNlMzE2ZjkyMGJiYl8xMzI4_5d54d2a4-bbda-4211-bada-173c68eeb24d"> false </dei:EntityExTransitionPeriod> |
| </xbrl> |