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<?xml version="1.0" encoding="windows-1252"?> |
<xbrl xmlns="http://www.xbrl.org/2003/instance" xmlns:XBIO="http://xeneticbio.com/20240322" xmlns:dei="http://xbrl.sec.gov/dei/2023" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:us-gaap="http://fasb.org/us-gaap/2023" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xlink="http://www.w3.org/1999/xlink"> |
| <link:schemaRef xlink:href="xbio-20240322.xsd" xlink:type="simple"/> |
| <context id="AsOf2024-03-22"> |
| | <entity> |
| | | <identifier scheme="http://www.sec.gov/CIK"> 0001534525 </identifier> |
| | | </entity> |
| | <period> |
| | | <startDate> 2024-03-22 </startDate> |
| | | <endDate> 2024-03-22 </endDate> |
| | | </period> |
| | </context> |
| <context id="From2024-03-222024-03-22_custom_CommonStock0.001ParValuePerShareMember"> |
| | <entity> |
| | | <identifier scheme="http://www.sec.gov/CIK"> 0001534525 </identifier> |
| | | <segment> |
| <xbrldi:explicitMember dimension="us-gaap:StatementClassOfStockAxis"> XBIO:CommonStock0.001ParValuePerShareMember </xbrldi:explicitMember> |
| </segment> |
| | | </entity> |
| | <period> |
| | | <startDate> 2024-03-22 </startDate> |
| | | <endDate> 2024-03-22 </endDate> |
| | | </period> |
| | </context> |
| <context id="From2024-03-222024-03-22_custom_PurchaseWarrantsMember"> |
| | <entity> |
| | | <identifier scheme="http://www.sec.gov/CIK"> 0001534525 </identifier> |
| | | <segment> |
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| </segment> |
| | | </entity> |
| | <period> |
| | | <startDate> 2024-03-22 </startDate> |
| | | <endDate> 2024-03-22 </endDate> |
| | | </period> |
| | </context> |
| <unit id="USD"> |
| | <measure> iso4217:USD </measure> |
| | </unit> |
| <unit id="Shares"> |
| | <measure> shares </measure> |
| | </unit> |
| <unit id="USDPShares"> |
| | <divide> |
| | | <unitNumerator> |
| <measure> iso4217:USD </measure> |
| </unitNumerator> |
| | | <unitDenominator> |
| <measure> shares </measure> |
| </unitDenominator> |
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| | </unit> |
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| <dei:SolicitingMaterial contextRef="AsOf2024-03-22" id="Fact000022"> false </dei:SolicitingMaterial> |
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| <dei:TradingSymbol contextRef="From2024-03-222024-03-22_custom_PurchaseWarrantsMember" id="Fact000029"> XBIOW </dei:TradingSymbol> |
| <dei:SecurityExchangeName contextRef="From2024-03-222024-03-22_custom_PurchaseWarrantsMember" id="Fact000030"> NASDAQ </dei:SecurityExchangeName> |
| <dei:EntityEmergingGrowthCompany contextRef="AsOf2024-03-22" id="Fact000031"> false </dei:EntityEmergingGrowthCompany> |
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