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<!-- DFIN ActiveDisclosure(SM) XBRL Schema Document - http://www.dfinsolutions.com/ --> |
<!-- Creation Date : 2020-11-05T18:27:43.0848377+00:00 --> |
<!-- Version : 5.0.1.513 --> |
<!-- Package ID : f2a6b57778d344c6a67ec9b6ad473d9e --> |
<!-- Copyright (c) 2020 Donnelley Financial Solutions, Inc. All Rights Reserved. --> |
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| <link:definition> 100350 - Disclosure - Stockholders' Equity - Additional Information (Detail) </link:definition> |
| <link:usedOn> link:calculationLink </link:usedOn> |
| <link:usedOn> link:presentationLink </link:usedOn> |
| <link:usedOn> link:definitionLink </link:usedOn> |
| </link:roleType> |
| | | <link:roleType roleURI="http://www.avrobio.com/20200930/taxonomy/role/DisclosureStockholdersEquitySummaryOfCommonStockReservedForFutureIssuanceDetail" id="Role_DisclosureStockholdersEquitySummaryOfCommonStockReservedForFutureIssuanceDetail"> |
| <link:definition> 100360 - Disclosure - Stockholders' Equity - Summary of Common Stock Reserved for Future Issuance (Detail) </link:definition> |
| <link:usedOn> link:calculationLink </link:usedOn> |
| <link:usedOn> link:presentationLink </link:usedOn> |
| <link:usedOn> link:definitionLink </link:usedOn> |
| </link:roleType> |
| | | <link:roleType roleURI="http://www.avrobio.com/20200930/taxonomy/role/DisclosureStockBasedCompensationSummaryOfAssumptionsThatUsedToDetermineGrantDateFairValueOfStockOptionsGrantedToEmployeesAndMembersOfBoardOfDirectorsDetail" id="Role_DisclosureStockBasedCompensationSummaryOfAssumptionsThatUsedToDetermineGrantDateFairValueOfStockOptionsGrantedToEmployeesAndMembersOfBoardOfDirectorsDetail"> |
| <link:definition> 100370 - Disclosure - Stock-Based Compensation - Summary of Assumptions that Used to Determine Grant-Date Fair Value of Stock Options Granted to Employees and Members of Board of Directors (Detail) </link:definition> |
| <link:usedOn> link:calculationLink </link:usedOn> |
| <link:usedOn> link:presentationLink </link:usedOn> |
| <link:usedOn> link:definitionLink </link:usedOn> |
| </link:roleType> |
| | | <link:roleType roleURI="http://www.avrobio.com/20200930/taxonomy/role/DisclosureStockBasedCompensationSummaryOfStockOptionActivityDetail" id="Role_DisclosureStockBasedCompensationSummaryOfStockOptionActivityDetail"> |
| <link:definition> 100380 - Disclosure - Stock-Based Compensation - Summary of Stock Option Activity (Detail) </link:definition> |
| <link:usedOn> link:calculationLink </link:usedOn> |
| <link:usedOn> link:presentationLink </link:usedOn> |
| <link:usedOn> link:definitionLink </link:usedOn> |
| </link:roleType> |
| | | <link:roleType roleURI="http://www.avrobio.com/20200930/taxonomy/role/DisclosureStockBasedCompensationAdditionalInformationDetail" id="Role_DisclosureStockBasedCompensationAdditionalInformationDetail"> |
| <link:definition> 100390 - Disclosure - Stock-Based Compensation - Additional Information (Detail) </link:definition> |
| <link:usedOn> link:calculationLink </link:usedOn> |
| <link:usedOn> link:presentationLink </link:usedOn> |
| <link:usedOn> link:definitionLink </link:usedOn> |
| </link:roleType> |
| | | <link:roleType roleURI="http://www.avrobio.com/20200930/taxonomy/role/DisclosureStockBasedCompensationSummaryOfRestrictedStockUnitActivityDetail" id="Role_DisclosureStockBasedCompensationSummaryOfRestrictedStockUnitActivityDetail"> |
| <link:definition> 100400 - Disclosure - Stock-Based Compensation - Summary of Restricted Stock Unit Activity (Detail) </link:definition> |
| <link:usedOn> link:calculationLink </link:usedOn> |
| <link:usedOn> link:presentationLink </link:usedOn> |
| <link:usedOn> link:definitionLink </link:usedOn> |
| </link:roleType> |
| | | <link:roleType roleURI="http://www.avrobio.com/20200930/taxonomy/role/DisclosureStockBasedCompensationScheduleOfStockBasedCompensationExpenseDetail" id="Role_DisclosureStockBasedCompensationScheduleOfStockBasedCompensationExpenseDetail"> |
| <link:definition> 100410 - Disclosure - Stock-Based Compensation - Schedule of Stock-based Compensation Expense (Detail) </link:definition> |
| <link:usedOn> link:calculationLink </link:usedOn> |
| <link:usedOn> link:presentationLink </link:usedOn> |
| <link:usedOn> link:definitionLink </link:usedOn> |
| </link:roleType> |
| | | <link:roleType roleURI="http://www.avrobio.com/20200930/taxonomy/role/DisclosureLicenseAgreementsAdditionalInformationDetail" id="Role_DisclosureLicenseAgreementsAdditionalInformationDetail"> |
| <link:definition> 100420 - Disclosure - License Agreements - Additional Information (Detail) </link:definition> |
| <link:usedOn> link:calculationLink </link:usedOn> |
| <link:usedOn> link:presentationLink </link:usedOn> |
| <link:usedOn> link:definitionLink </link:usedOn> |
| </link:roleType> |
| | | <link:roleType roleURI="http://www.avrobio.com/20200930/taxonomy/role/DisclosureNetLossPerShareAttributableToCommonStockholdersScheduleOfDilutiveCommonStockEquivalentsExcludedFromComputationOfDilutedNetLossPerShareDetail" id="Role_DisclosureNetLossPerShareAttributableToCommonStockholdersScheduleOfDilutiveCommonStockEquivalentsExcludedFromComputationOfDilutedNetLossPerShareDetail"> |
| <link:definition> 100430 - Disclosure - Net Loss per Share Attributable to Common Stockholders - Schedule of Dilutive Common Stock Equivalents Excluded from Computation of Diluted Net Loss per Share (Detail) </link:definition> |
| <link:usedOn> link:calculationLink </link:usedOn> |
| <link:usedOn> link:presentationLink </link:usedOn> |
| <link:usedOn> link:definitionLink </link:usedOn> |
| </link:roleType> |
| | | <link:roleType roleURI="http://www.avrobio.com/20200930/taxonomy/role/DisclosureCommitmentsAndContingenciesAdditionalInformationDetail" id="Role_DisclosureCommitmentsAndContingenciesAdditionalInformationDetail"> |
| <link:definition> 100440 - Disclosure - Commitments and Contingencies - Additional Information (Detail) </link:definition> |
| <link:usedOn> link:calculationLink </link:usedOn> |
| <link:usedOn> link:presentationLink </link:usedOn> |
| <link:usedOn> link:definitionLink </link:usedOn> |
| </link:roleType> |
| | | <link:roleType roleURI="http://www.avrobio.com/20200930/taxonomy/role/DisclosureRelatedPartyTransactionsAdditionalInformationDetail" id="Role_DisclosureRelatedPartyTransactionsAdditionalInformationDetail"> |
| <link:definition> 100450 - Disclosure - Related Party Transactions - Additional information (Detail) </link:definition> |
| <link:usedOn> link:calculationLink </link:usedOn> |
| <link:usedOn> link:presentationLink </link:usedOn> |
| <link:usedOn> link:definitionLink </link:usedOn> |
| </link:roleType> |
| | | </xsd:appinfo> |
| | </xsd:annotation> |
| <xsd:element id="avro_AtTheMarketFacilityMember" name="AtTheMarketFacilityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/> |
| <xsd:element id="avro_DeferredRentExpense" name="DeferredRentExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/> |
| <xsd:element id="avro_PrepaidExpensesAndOtherCurrentAssetsDisclosureTextBlock" name="PrepaidExpensesAndOtherCurrentAssetsDisclosureTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/> |
| <xsd:element id="avro_LicenseAgreementDisclosureTextBlock" name="LicenseAgreementDisclosureTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/> |
| <xsd:element id="avro_ReclassificationsPolicyTextBlock" name="ReclassificationsPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/> |
| <xsd:element id="avro_EmergingGrowthCompanyStatusPolicyTextBlock" name="EmergingGrowthCompanyStatusPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/> |
| <xsd:element id="avro_RecentlyAdoptedAccountingPronouncementsPolicyTextBlock" name="RecentlyAdoptedAccountingPronouncementsPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/> |
| <xsd:element id="avro_ScheduleOfAccruedExpensesAndOtherCurrentLiabilitiesTableTextBlock" name="ScheduleOfAccruedExpensesAndOtherCurrentLiabilitiesTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/> |
| <xsd:element id="avro_FairValueInputAmountTransferBetweenLevels" name="FairValueInputAmountTransferBetweenLevels" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/> |
| <xsd:element id="avro_TaxIncentiveRefundCurrent" name="TaxIncentiveRefundCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/> |
| <xsd:element id="avro_PrepaidResearchAndDevelopmentCostsCurrent" name="PrepaidResearchAndDevelopmentCostsCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/> |
| <xsd:element id="avro_PrepaidCompensationAndBenefitCostsCurrent" name="PrepaidCompensationAndBenefitCostsCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/> |
| <xsd:element id="avro_AccruedResearchAndDevelopmentExpenseCurrent" name="AccruedResearchAndDevelopmentExpenseCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/> |
| <xsd:element id="avro_AccruedLicenseAgreementCurrent" name="AccruedLicenseAgreementCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/> |
| <xsd:element id="avro_UndesignatedPreferredStock" name="UndesignatedPreferredStock" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/> |
| <xsd:element id="avro_UndesignatedPreferredStockOutstanding" name="UndesignatedPreferredStockOutstanding" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/> |
| <xsd:element id="avro_TwoThousandEighteenStockOptionAndIncentivePlanMember" name="TwoThousandEighteenStockOptionAndIncentivePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/> |
| <xsd:element id="avro_TwoThousandEighteenEmployeeStockPurchasePlanMember" name="TwoThousandEighteenEmployeeStockPurchasePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/> |
| <xsd:element id="avro_TwoThousandNineteenInducementPlanMember" name="TwoThousandNineteenInducementPlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/> |
| <xsd:element id="avro_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedAndExpirationsInPeriod" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedAndExpirationsInPeriod" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/> |
| <xsd:element id="avro_AdditionalResearchAndDevelopmentExpense" name="AdditionalResearchAndDevelopmentExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/> |
| <xsd:element id="avro_UpfrontLicenseFees" name="UpfrontLicenseFees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/> |
| <xsd:element id="avro_LicenseAgreementsAbstract" name="LicenseAgreementsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/> |
| <xsd:element id="avro_LicenseAgreementLineItems" name="LicenseAgreementLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/> |
| <xsd:element id="avro_LicenseAgreementTable" name="LicenseAgreementTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/> |
| <xsd:element id="avro_UniversityOfManchesterAgreementMember" name="UniversityOfManchesterAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/> |
| <xsd:element id="avro_MPSIILicenseAgreementMember" name="MPSIILicenseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/> |
| <xsd:element id="avro_UHNagreementMember" name="UHNagreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/> |
| <xsd:element id="avro_FabrylicenseagreementMember" name="FabrylicenseagreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/> |
| <xsd:element id="avro_Interleukin12LicenseAgreementMember" name="Interleukin12LicenseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/> |
| <xsd:element id="avro_BioMarinPharmaceuticalIncMember" name="BioMarinPharmaceuticalIncMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/> |
| <xsd:element id="avro_GenstemTherapeuticsIncMember" name="GenstemTherapeuticsIncMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/> |
| <xsd:element id="avro_LundUniversityRightsHoldersAgreementMember" name="LundUniversityRightsHoldersAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/> |
| <xsd:element id="avro_MilestonePayments" name="MilestonePayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/> |
| <xsd:element id="avro_MilestonePaymentPaid" name="MilestonePaymentPaid" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/> |
| <xsd:element id="avro_MilestonePaymentDue" name="MilestonePaymentDue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/> |
| <xsd:element id="avro_AgreementExpirationPeriod" name="AgreementExpirationPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/> |
| <xsd:element id="avro_AgreementExpirationDescription" name="AgreementExpirationDescription" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/> |
| <xsd:element id="avro_ClinicalTrialCostRelatedToResearchAndDevelopmentExpense" name="ClinicalTrialCostRelatedToResearchAndDevelopmentExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/> |
| <xsd:element id="avro_CostOfMilestonePayment" name="CostOfMilestonePayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/> |
| <xsd:element id="avro_OptionFee" name="OptionFee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/> |
| <xsd:element id="avro_MilestoneFees" name="MilestoneFees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/> |
| <xsd:element id="avro_LicenseMaintenanceFees" name="LicenseMaintenanceFees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/> |
| <xsd:element id="avro_PaymentsUponClosingOfInitialPublicOffering" name="PaymentsUponClosingOfInitialPublicOffering" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/> |
| <xsd:element id="avro_LicenseAgreementExpenses" name="LicenseAgreementExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/> |
| <xsd:element id="avro_MilestonePayment" name="MilestonePayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/> |
| <xsd:element id="avro_LeaseExpirationMonthAndYear" name="LeaseExpirationMonthAndYear" type="xbrli:gYearMonthItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/> |
| <xsd:element id="avro_OperatingLeaseAnnualIncreaseInRentalPercentage" name="OperatingLeaseAnnualIncreaseInRentalPercentage" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/> |
| <xsd:element id="avro_AnnualLeasePaymentsDescription" name="AnnualLeasePaymentsDescription" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/> |
| <xsd:element id="avro_IncreaseDecreaseInLeaseObligations" name="IncreaseDecreaseInLeaseObligations" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/> |
| <xsd:element id="avro_CommitmentsAndContingenciesDisclosureLineItems" name="CommitmentsAndContingenciesDisclosureLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/> |
| <xsd:element id="avro_CommitmentsAndContingenciesDisclosureTable" name="CommitmentsAndContingenciesDisclosureTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/> |
| <xsd:element id="avro_LicenseAgreementMember" name="LicenseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/> |
| <xsd:element id="avro_OfficersAndBoardMembersMember" name="OfficersAndBoardMembersMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/> |
| <xsd:element id="avro_SubleaseAgreementMember" name="SubleaseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/> |
| </xsd:schema> |