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Achieve Life Sciences, Inc. – ‘10-Q’ for 6/30/22 – ‘EX-101.DEF’

On:  Thursday, 8/11/22, at 4:11pm ET   ·   For:  6/30/22   ·   Accession #:  1564590-22-29122   ·   File #:  33-80623

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  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 8/11/22  Achieve Life Sciences, Inc.       10-Q        6/30/22   60:7.3M                                   ActiveDisclosure/FA

Quarterly Report   —   Form 10-Q

Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-Q        Quarterly Report                                    HTML   2.15M 
 2: EX-31.1     Certification -- §302 - SOA'02                      HTML     22K 
 3: EX-32.1     Certification -- §906 - SOA'02                      HTML     20K 
 9: R1          Document and Entity Information                     HTML     75K 
10: R2          Consolidated Balance Sheets (Unaudited)             HTML    118K 
11: R3          Consolidated Balance Sheets (Parenthetical)         HTML     39K 
                (Unaudited)                                                      
12: R4          Consolidated Statements of Loss and Comprehensive   HTML     69K 
                Loss (Unaudited)                                                 
13: R5          Consolidated Statements of Cash Flows (Unaudited)   HTML     84K 
14: R6          Consolidated Statements of Stockholder's Equity     HTML     86K 
                (Unaudited)                                                      
15: R7          Nature of Business, Basis of Presentation and       HTML     28K 
                Going Concern Uncertainty                                        
16: R8          Accounting Policies                                 HTML     23K 
17: R9          Government Grant                                    HTML     23K 
18: R10         Intangibles                                         HTML     62K 
19: R11         License Agreements                                  HTML     27K 
20: R12         Fair Value Measurements                             HTML    132K 
21: R13         Convertible Debt                                    HTML     58K 
22: R14         Common Stock                                        HTML    207K 
23: R15         Commitments and Contingencies                       HTML    128K 
24: R16         Intangibles (Tables)                                HTML     62K 
25: R17         Fair Value Measurements (Tables)                    HTML    149K 
26: R18         Convertible Debt (Tables)                           HTML     70K 
27: R19         Common Stock (Tables)                               HTML    186K 
28: R20         Commitments and Contingencies (Tables)              HTML    125K 
29: R21         Nature of Business, Basis of Presentation and       HTML     43K 
                Going Concern Uncertainty - Additional Information               
                (Detail)                                                         
30: R22         Government Grant - Additional Information           HTML     31K 
                (Details)                                                        
31: R23         Intangibles - Additional Information (Detail)       HTML     29K 
32: R24         Intangibles - Components of Intangible Assets       HTML     28K 
                (Detail)                                                         
33: R25         Intangibles - Estimated Future Amortization         HTML     30K 
                Expense Related to Intangible Assets (Detail)                    
34: R26         License Agreements - Additional Information         HTML     27K 
                (Detail)                                                         
35: R27         Fair Value Measurements - Additional Information    HTML     24K 
                (Detail)                                                         
36: R28         Fair Value Measurements - Summary of Assets         HTML     30K 
                Measured at Fair Value on Recurring Basis (Detail)               
37: R29         Fair Value Measurements - Summary of Cash           HTML     27K 
                Equivalents (Detail)                                             
38: R30         Fair Value Measurements - Schedule of Aggregate     HTML     27K 
                Fair Value of Principal Amount of Convertible Debt               
                (Detail)                                                         
39: R31         Convertible Debt - Additional Information           HTML     73K 
                (Details)                                                        
40: R32         Convertible Debt - Schedule of Convertible Debt     HTML     30K 
                Balance (Details)                                                
41: R33         Common Stock - Authorized - Additional Information  HTML     27K 
                (Detail)                                                         
42: R34         Common Stock - Issued and Outstanding Shares -      HTML     57K 
                Additional Information (Detail)                                  
43: R35         Common Stock - Stock Options - Additional           HTML    100K 
                Information (Detail)                                             
44: R36         Common Stock - Summary of Stock Options Activity    HTML     34K 
                (Detail)                                                         
45: R37         Common Stock - Summary of Fair Value of Each Stock  HTML     29K 
                Award for Employees and Directors (Detail)                       
46: R38         Common Stock - Summary of Share-Based Compensation  HTML     27K 
                Expense for Stock Options, Restricted Stock and                  
                Employee Share Purchase Plan (Detail)                            
47: R39         Common Stock - Restricted Stock Unit Awards -       HTML     30K 
                Additional Information (Detail)                                  
48: R40         Common Stock - Summary of Restricted Stock Unit     HTML     37K 
                Award Activity (Detail)                                          
49: R41         Common Stock - Employee Share Purchase Plan -       HTML     24K 
                Additional Information (Detail)                                  
50: R42         Common Stock - Summary of Outstanding Warrants      HTML     52K 
                (Detail)                                                         
51: R43         Common Stock - Common Stock Warrants - Additional   HTML     31K 
                Information (Detail)                                             
52: R44         Commitments and Contingencies - Summary of          HTML     25K 
                Contractual Obligations (Detail)                                 
53: R45         Commitments and Contingencies - Additional          HTML     68K 
                Information (Detail)                                             
54: R46         Commitments and Contingencies - Summary of Future   HTML     26K 
                Minimum Annual Lease Payments (Detail)                           
55: R47         Commitments and Contingencies - Summary of Other    HTML     28K 
                Information Related to Leases (Detail)                           
58: XML         IDEA XML File -- Filing Summary                      XML    109K 
56: XML         XBRL Instance -- achv-10q_20220630_htm               XML   1.57M 
57: EXCEL       IDEA Workbook of Financial Reports                  XLSX     98K 
 5: EX-101.CAL  XBRL Calculations -- achv-20220630_cal               XML    110K 
 6: EX-101.DEF  XBRL Definitions -- achv-20220630_def                XML    496K 
 7: EX-101.LAB  XBRL Labels -- achv-20220630_lab                     XML    967K 
 8: EX-101.PRE  XBRL Presentations -- achv-20220630_pre              XML    710K 
 4: EX-101.SCH  XBRL Schema -- achv-20220630                         XSD    150K 
59: JSON        XBRL Instance as JSON Data -- MetaLinks              288±   461K 
60: ZIP         XBRL Zipped Folder -- 0001564590-22-029122-xbrl      Zip    350K 


‘EX-101.DEF’   —   XBRL Definitions — achv-20220630_def


This Exhibit is an XBRL XML File.


                                                                                                                                                                                
<?xml version="1.0" encoding="windows-1252"?>
<!-- DFIN ActiveDisclosure(SM) XBRL Linkbase Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date : 2022-08-04T21:09:01.6766473+00:00 -->
<!-- Version : 5.0.1.747 -->
<!-- Package ID : 3521f3e1fb7a4adbb0298f01b09c20f7 -->
<!-- Copyright (c) 2022 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
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<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:type="locator" xlink:label="us-gaap_RetainedEarningsAccumulatedDeficit"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapitalCommonStock" xlink:type="locator" xlink:label="us-gaap_AdditionalPaidInCapitalCommonStock"/>
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<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockValue" xlink:type="locator" xlink:label="us-gaap_PreferredStockValue"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityAbstract" xlink:type="locator" xlink:label="us-gaap_StockholdersEquityAbstract"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingencies" xlink:type="locator" xlink:label="us-gaap_CommitmentsAndContingencies"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities" xlink:type="locator" xlink:label="us-gaap_Liabilities"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent" xlink:type="locator" xlink:label="us-gaap_OperatingLeaseLiabilityNoncurrent"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConvertibleDebtNoncurrent" xlink:type="locator" xlink:label="us-gaap_ConvertibleDebtNoncurrent"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrent" xlink:type="locator" xlink:label="us-gaap_LiabilitiesCurrent"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityCurrent" xlink:type="locator" xlink:label="us-gaap_OperatingLeaseLiabilityCurrent"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent" xlink:type="locator" xlink:label="us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
<link:loc xlink:href="achv-20220630.xsd#achv_AccruedLiabilitiesClinicalCurrent" xlink:type="locator" xlink:label="achv_AccruedLiabilitiesClinicalCurrent"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAccruedLiabilitiesCurrent" xlink:type="locator" xlink:label="us-gaap_OtherAccruedLiabilitiesCurrent"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableCurrent" xlink:type="locator" xlink:label="us-gaap_AccountsPayableCurrent"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrentAbstract" xlink:type="locator" xlink:label="us-gaap_LiabilitiesCurrentAbstract"/>
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<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Assets" xlink:type="locator" xlink:label="us-gaap_Assets"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Goodwill" xlink:type="locator" xlink:label="us-gaap_Goodwill"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsNet" xlink:type="locator" xlink:label="us-gaap_FiniteLivedIntangibleAssetsNet"/>
<link:loc xlink:href="achv-20220630.xsd#achv_OtherAssetsAndRestrictedCash" xlink:type="locator" xlink:label="achv_OtherAssetsAndRestrictedCash"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAsset" xlink:type="locator" xlink:label="us-gaap_OperatingLeaseRightOfUseAsset"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent" xlink:type="locator" xlink:label="us-gaap_AssetsCurrent"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:type="locator" xlink:label="us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GrantsReceivableCurrent" xlink:type="locator" xlink:label="us-gaap_GrantsReceivableCurrent"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:type="locator" xlink:label="us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrentAbstract" xlink:type="locator" xlink:label="us-gaap_AssetsCurrentAbstract"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsAbstract" xlink:type="locator" xlink:label="us-gaap_AssetsAbstract"/>
<link:loc xlink:href="achv-20220630.xsd#achv_SeriesBConvertiblePreferredStockMember" xlink:type="locator" xlink:label="achv_SeriesBConvertiblePreferredStockMember"/>
<link:loc xlink:href="achv-20220630.xsd#achv_SeriesAConvertiblePreferredStockMember" xlink:type="locator" xlink:label="achv_SeriesAConvertiblePreferredStockMember"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:type="locator" xlink:label="us-gaap_ClassOfStockDomain"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:type="locator" xlink:label="us-gaap_ClassOfStockDomain_2"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:type="locator" xlink:label="us-gaap_StatementClassOfStockAxis"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable" xlink:type="locator" xlink:label="us-gaap_StatementTable"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:type="locator" xlink:label="us-gaap_StatementLineItems"/>
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LiabilitiesCurrentAbstract" xlink:to="us-gaap_EmployeeRelatedLiabilitiesCurrent" order="11190.00" priority="2" use="optional"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LiabilitiesCurrentAbstract" xlink:to="us-gaap_OperatingLeaseLiabilityCurrent" order="11230.00" priority="2" use="optional"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_LiabilitiesCurrentAbstract" xlink:to="us-gaap_LiabilitiesCurrent" order="11270.00" priority="2" use="optional"/>
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_OtherCommitmentsLineItems" xlink:to="achv_LeaseSecurityDepositYearOne" order="10980.00" priority="2" use="optional"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_OtherCommitmentsLineItems" xlink:to="achv_LeaseSecurityDepositYearTwo" order="11000.00" priority="2" use="optional"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_OtherCommitmentsLineItems" xlink:to="achv_LeaseSecurityDepositThereafter" order="11020.00" priority="2" use="optional"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_OtherCommitmentsLineItems" xlink:to="us-gaap_OperatingLeaseExpense" order="11070.00" priority="2" use="optional"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_OtherCommitmentsLineItems" xlink:to="us-gaap_GuaranteeObligationsCurrentCarryingValue" order="11180.00" priority="2" use="optional"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_OtherCommitmentsLineItems" xlink:to="achv_IndemnificationExpense" order="11230.00" priority="2" use="optional"/>
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<link:roleRef roleURI="http://achievelifesciences.com/20220630/taxonomy/role/DisclosureCommitmentsAndContingenciesSummaryOfFutureMinimumAnnualLeasePaymentsDetail" xlink:href="achv-20220630.xsd#Role_DisclosureCommitmentsAndContingenciesSummaryOfFutureMinimumAnnualLeasePaymentsDetail" xlink:type="simple"/>
<link:definitionLink xlink:type="extended" xlink:role="http://achievelifesciences.com/20220630/taxonomy/role/DisclosureCommitmentsAndContingenciesSummaryOfFutureMinimumAnnualLeasePaymentsDetail">
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<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths" xlink:type="locator" xlink:label="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear" xlink:type="locator" xlink:label="us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
<link:loc xlink:href="achv-20220630.xsd#achv_VancouverOfficeOperatingLeaseMember" xlink:type="locator" xlink:label="achv_VancouverOfficeOperatingLeaseMember"/>
<link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:type="locator" xlink:label="us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_TypeOfArrangementAxis" xlink:to="us-gaap_ArrangementsAndNonarrangementTransactionsMember" order="10090.00" priority="2" use="optional"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:to="achv_VancouverOfficeOperatingLeaseMember" order="10110.00" priority="2" use="optional"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_OperatingLeasedAssetsLineItems" xlink:to="us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear" order="10180.00" priority="2" use="optional"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_OperatingLeasedAssetsLineItems" xlink:to="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths" order="10200.00" priority="2" use="optional"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_OperatingLeasedAssetsLineItems" xlink:to="us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue" order="10220.00" priority="2" use="optional"/>
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2 Subsequent Filings that Reference this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 1/12/23  Achieve Life Sciences, Inc.       424B7                  1:173K                                   Donnelley … Solutions/FA
12/29/22  Achieve Life Sciences, Inc.       S-3                    4:276K                                   Donnelley … Solutions/FA


1 Previous Filing that this Filing References

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 4/27/22  Achieve Life Sciences, Inc.       8-K:1,2,8,9 4/26/22   14:3.8M                                   ActiveDisclosure/FA
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