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AVROBIO, Inc. – ‘10-K’ for 12/31/21 – ‘EX-101.SCH’

On:  Thursday, 3/17/22, at 4:50pm ET   ·   For:  12/31/21   ·   Accession #:  1564590-22-10895   ·   File #:  1-38537

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  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 3/17/22  AVROBIO, Inc.                     10-K       12/31/21   78:9.1M                                   ActiveDisclosure/FA

Annual Report   —   Form 10-K

Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-K        Annual Report                                       HTML   1.29M 
 2: EX-10.22    Material Contract                                   HTML    144K 
 3: EX-21.1     Subsidiaries List                                   HTML     23K 
 4: EX-23.1     Consent of Expert or Counsel                        HTML     28K 
 5: EX-31.1     Certification -- §302 - SOA'02                      HTML     31K 
 6: EX-31.2     Certification -- §302 - SOA'02                      HTML     31K 
 7: EX-32.1     Certification -- §906 - SOA'02                      HTML     26K 
13: R1          Document and Entity Information                     HTML     99K 
14: R2          Consolidated Balance Sheets                         HTML    108K 
15: R3          Consolidated Balance Sheets (Parenthetical)         HTML     40K 
16: R4          Consolidated Statements of Operations and           HTML     61K 
                Comprehensive Loss                                               
17: R5          Consolidated Statements of Stockholders' Equity     HTML     75K 
18: R6          Consolidated Statements of Stockholders' Equity     HTML     27K 
                (Parenthetical)                                                  
19: R7          Consolidated Statements of Cash Flows               HTML    104K 
20: R8          Nature of the Business                              HTML     28K 
21: R9          Summary of Significant Accounting Policies          HTML     68K 
22: R10         License Agreements                                  HTML     46K 
23: R11         Fair Value of Financial Assets and Liabilities      HTML     79K 
24: R12         Supplemental Balance Sheet Information              HTML    111K 
25: R13         Commitments and Contingencies                       HTML     45K 
26: R14         Note Payable                                        HTML     56K 
27: R15         Common Stock                                        HTML     65K 
28: R16         Stock-Based Compensation                            HTML    144K 
29: R17         401(k) Savings Plan                                 HTML     29K 
30: R18         Income Taxes                                        HTML    116K 
31: R19         Net Loss per Share                                  HTML     44K 
32: R20         Related Party Transactions                          HTML     28K 
33: R21         Subsequent Events                                   HTML     28K 
34: R22         Summary of Significant Accounting Policies          HTML    113K 
                (Policies)                                                       
35: R23         Summary of Significant Accounting Policies          HTML     29K 
                (Tables)                                                         
36: R24         Fair Value of Financial Assets and Liabilities      HTML     79K 
                (Tables)                                                         
37: R25         Supplemental Balance Sheet Information (Tables)     HTML    116K 
38: R26         Commitments and Contingencies (Tables)              HTML     37K 
39: R27         Note Payable (Tables)                               HTML     49K 
40: R28         Common Stock (Tables)                               HTML     58K 
41: R29         Stock-Based Compensation (Tables)                   HTML    135K 
42: R30         Income Taxes (Tables)                               HTML    109K 
43: R31         Net Loss per Share (Tables)                         HTML     43K 
44: R32         Nature of the Business - Additional Information     HTML     29K 
                (Detail)                                                         
45: R33         Summary of Significant Accounting Policies -        HTML     34K 
                Additional Information (Detail)                                  
46: R34         Summary of Significant Accounting Policies -        HTML     33K 
                Schedule of Property and Equipment Estimated                     
                Useful Life (Detail)                                             
47: R35         License Agreements - Additional Information         HTML     90K 
                (Detail)                                                         
48: R36         Fair Value of Financial Assets and Liabilities -    HTML     32K 
                Summary of Financial Assets and Liabilities                      
                Measured at Fair Value on Recurring Basis (Detail)               
49: R37         Fair Value of Financial Assets and Liabilities -    HTML     24K 
                Additional Information (Detail)                                  
50: R38         Supplemental Balance Sheet Information - Summary    HTML     38K 
                of Prepaid Expenses and Other Current Assets                     
                (Detail)                                                         
51: R39         Supplemental Balance Sheet Information - Summary    HTML     38K 
                of Property and Equipment, Net (Detail)                          
52: R40         Supplemental Balance Sheet Information -            HTML     25K 
                Additional Information (Detail)                                  
53: R41         Supplemental Balance Sheet Information - Summary    HTML     25K 
                of Restricted Cash (Detail)                                      
54: R42         Supplemental Balance Sheet Information - Summary    HTML     35K 
                of Accrued Expenses (Detail)                                     
55: R43         Commitments and Contingencies - Additional          HTML     48K 
                Information (Detail)                                             
56: R44         Commitments and Contingencies - Summary of Future   HTML     35K 
                Minimum Lease Payments Due Under Operating Leases                
                (Detail)                                                         
57: R45         Note Payable - Additional Information (Details)     HTML     70K 
58: R46         Note Payable - Carrying Value of Note Payable       HTML     30K 
                (Details)                                                        
59: R47         Note Payable - Future Principal Payments (Details)  HTML     35K 
60: R48         Common Stock - Additional Information (Detail)      HTML     65K 
61: R49         Common Stock - Summary of Common Stock Reserved     HTML     39K 
                for Future Issuance (Detail)                                     
62: R50         Stock-Based Compensation - Additional Information   HTML     80K 
                (Detail)                                                         
63: R51         Stock-Based Compensation - Summary of Assumptions   HTML     31K 
                that Used to Determine Grant-Date Fair Value of                  
                Stock Options Granted to Employees and Members of                
                Board (Detail)                                                   
64: R52         Stock-Based Compensation - Summary of Stock Option  HTML     58K 
                Activity (Detail)                                                
65: R53         Stock-Based Compensation - Summary of Restricted    HTML     43K 
                Stock Award and Restricted Stock Unit Activity                   
                (Detail)                                                         
66: R54         Stock-Based Compensation - Schedule of Stock-based  HTML     30K 
                Compensation Expense (Detail)                                    
67: R55         401(k) Savings Plan - Additional Information        HTML     30K 
                (Detail)                                                         
68: R56         Income Taxes - Additional Information (Detail)      HTML     68K 
69: R57         Income Taxes - Schedule of Reconciliation of        HTML     43K 
                Income Tax Expense (Benefit) (Detail)                            
70: R58         Income Taxes - Schedule of Deferred Tax Assets and  HTML     46K 
                Liabilities (Detail)                                             
71: R59         Net Loss per Share - Schedule of Dilutive Common    HTML     30K 
                Stock Equivalents Excluded from Computation of                   
                Diluted Net Loss per Share (Detail)                              
72: R60         Related Party Transactions - Additional             HTML     41K 
                Information (Detail)                                             
73: R61         Subsequent Events - Additional Information          HTML     28K 
                (Detail)                                                         
76: XML         IDEA XML File -- Filing Summary                      XML    140K 
74: XML         XBRL Instance -- avro-10k_20211231_htm               XML   1.65M 
75: EXCEL       IDEA Workbook of Financial Reports                  XLSX     92K 
 9: EX-101.CAL  XBRL Calculations -- avro-20211231_cal               XML    140K 
10: EX-101.DEF  XBRL Definitions -- avro-20211231_def                XML    456K 
11: EX-101.LAB  XBRL Labels -- avro-20211231_lab                     XML   1.18M 
12: EX-101.PRE  XBRL Presentations -- avro-20211231_pre              XML    826K 
 8: EX-101.SCH  XBRL Schema -- avro-20211231                         XSD    171K 
77: JSON        XBRL Instance as JSON Data -- MetaLinks              347±   525K 
78: ZIP         XBRL Zipped Folder -- 0001564590-22-010895-xbrl      Zip    445K

‘EX-101.SCH’   —   XBRL Schema — avro-20211231

This Exhibit is an XBRL XML File.

                                                                                                                                                                                
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<xsd:element id="avro_CollaborativeAgreementExpenses" name="CollaborativeAgreementExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
<xsd:element id="avro_OptionFee" name="OptionFee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
<xsd:element id="avro_MilestoneFees" name="MilestoneFees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
<xsd:element id="avro_LicenseMaintenanceFees" name="LicenseMaintenanceFees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
<xsd:element id="avro_PaymentsUponClosingOfInitialPublicOffering" name="PaymentsUponClosingOfInitialPublicOffering" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
<xsd:element id="avro_LicenseAgreementExpenses" name="LicenseAgreementExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
<xsd:element id="avro_MilestonePayment" name="MilestonePayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
<xsd:element id="avro_FairValueInputAmountTransferBetweenLevels" name="FairValueInputAmountTransferBetweenLevels" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
<xsd:element id="avro_TaxIncentiveRefundCurrent" name="TaxIncentiveRefundCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
<xsd:element id="avro_PrepaidResearchAndDevelopmentCostsCurrent" name="PrepaidResearchAndDevelopmentCostsCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
<xsd:element id="avro_PrepaidCompensationBenefits" name="PrepaidCompensationBenefits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
<xsd:element id="avro_SupplementalBalanceSheetInformationDisclosuresAbstract" name="SupplementalBalanceSheetInformationDisclosuresAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_AccruedResearchAndDevelopmentExpenseCurrent" name="AccruedResearchAndDevelopmentExpenseCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
<xsd:element id="avro_LeaseExpirationMonthAndYear" name="LeaseExpirationMonthAndYear" type="xbrli:gYearMonthItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
<xsd:element id="avro_OperatingLeaseAnnualIncreaseInRentalPercentage" name="OperatingLeaseAnnualIncreaseInRentalPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
<xsd:element id="avro_CommitmentsAndContingenciesDisclosureLineItems" name="CommitmentsAndContingenciesDisclosureLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_CommitmentsAndContingenciesDisclosureTable" name="CommitmentsAndContingenciesDisclosureTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_RestrictedCashMember" name="RestrictedCashMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_AnnualLeasePaymentsDescription" name="AnnualLeasePaymentsDescription" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
<xsd:element id="avro_DebtInstrumentNumberOfTranches" name="DebtInstrumentNumberOfTranches" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
<xsd:element id="avro_LineOfCreditFacilityAdditionalDiscretionary" name="LineOfCreditFacilityAdditionalDiscretionary" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
<xsd:element id="avro_EndOfTermChargeAsPercentageOnPrincipalAmount" name="EndOfTermChargeAsPercentageOnPrincipalAmount" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
<xsd:element id="avro_DebtDisclosureLineItems" name="DebtDisclosureLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_DebtDisclosureTable" name="DebtDisclosureTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_LoanAndSecurityAgreementMember" name="LoanAndSecurityAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_TermLoanFacilityMember" name="TermLoanFacilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_SiliconValleyBankMember" name="SiliconValleyBankMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_RegulatoryMilestoneMember" name="RegulatoryMilestoneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_TermLoanPrepaymentDuringFirstYearMember" name="TermLoanPrepaymentDuringFirstYearMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_TermLoanPrepaymentDuringSecondYearMember" name="TermLoanPrepaymentDuringSecondYearMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_TermLoanPrepaymentAfterSecondYearMember" name="TermLoanPrepaymentAfterSecondYearMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_LegalExpensesMember" name="LegalExpensesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_LineOfCreditFacilityPrepaymentOfPremiumPercentage" name="LineOfCreditFacilityPrepaymentOfPremiumPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
<xsd:element id="avro_UndesignatedPreferredStock" name="UndesignatedPreferredStock" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
<xsd:element id="avro_UndesignatedSharesOfPreferredStockOutstanding" name="UndesignatedSharesOfPreferredStockOutstanding" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
<xsd:element id="avro_JulyTwoThousandNineteenFollowOnOfferingMember" name="JulyTwoThousandNineteenFollowOnOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_FebruaryTwoThousandTwentyFollowOnOfferingMember" name="FebruaryTwoThousandTwentyFollowOnOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_NovemberTwoThousandTwentyFollowOnOfferingMember" name="NovemberTwoThousandTwentyFollowOnOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_CommonStockCapitalSharesAmountAvailableForFutureIssuance" name="CommonStockCapitalSharesAmountAvailableForFutureIssuance" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
<xsd:element id="avro_TwoThousandEighteenStockOptionAndIncentivePlanMember" name="TwoThousandEighteenStockOptionAndIncentivePlanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_TwoThousandNineteenInducementPlanMember" name="TwoThousandNineteenInducementPlanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_TwoThousandTwentyInducementPlanMember" name="TwoThousandTwentyInducementPlanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_TwoThousandFifteenStockOptionAndGrantPlanMember" name="TwoThousandFifteenStockOptionAndGrantPlanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_NumberOfSharesOfCommonStockOutstandingIncreasePercentage" name="NumberOfSharesOfCommonStockOutstandingIncreasePercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
<xsd:element id="avro_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedAndExpirationsInPeriod" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedAndExpirationsInPeriod" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
<xsd:element id="avro_AdditionalResearchAndDevelopmentExpense" name="AdditionalResearchAndDevelopmentExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
<xsd:element id="avro_IncomeTaxesLineItems" name="IncomeTaxesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_IncomeTaxesTable" name="IncomeTaxesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_ExpirationThrough2037Member" name="ExpirationThrough2037Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_ExpirationThrough2039Member" name="ExpirationThrough2039Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_OrphanDrugCreditMember" name="OrphanDrugCreditMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_ExpirationThrough2033Member" name="ExpirationThrough2033Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_EffectiveIncomeTaxRateReconciliationPermanentDifference" name="EffectiveIncomeTaxRateReconciliationPermanentDifference" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
<xsd:element id="avro_DeferredTaxAssetsCapitalizedStartUpAndOrganizationalCosts" name="DeferredTaxAssetsCapitalizedStartUpAndOrganizationalCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
<xsd:element id="avro_DeferredTaxAssetsLicenseAgreement" name="DeferredTaxAssetsLicenseAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
<xsd:element id="avro_PayrollTaxLiabilityCappedPerYear" name="PayrollTaxLiabilityCappedPerYear" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
<xsd:element id="avro_TaxCreditCarryforwardsExpirationPeriod" name="TaxCreditCarryforwardsExpirationPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
<xsd:element id="avro_OperatingLossAndTaxCreditCarryforwardsLimitationsThresholdPercentageOfCumulativeChangesInOwnershipInterestOfSignificantShareholdersConsidered" name="OperatingLossAndTaxCreditCarryforwardsLimitationsThresholdPercentageOfCumulativeChangesInOwnershipInterestOfSignificantShareholdersConsidered" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
<xsd:element id="avro_OperatingLossAndTaxCreditCarryforwardsLimitationsPeriodOverWhichCumulativeChangesInOwnershipInterestOfSignificantShareholdersConsidered" name="OperatingLossAndTaxCreditCarryforwardsLimitationsPeriodOverWhichCumulativeChangesInOwnershipInterestOfSignificantShareholdersConsidered" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
<xsd:element id="avro_RestrictedStockAwardsAndUnitsMember" name="RestrictedStockAwardsAndUnitsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_ProvisionForMaximumCashPayment" name="ProvisionForMaximumCashPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
<xsd:element id="avro_LicenseAgreementMember" name="LicenseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_StockPurchaseAgreementMember" name="StockPurchaseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_OfficersAndBoardMembersMember" name="OfficersAndBoardMembersMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
<xsd:element id="avro_SubleaseAgreementMember" name="SubleaseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
</xsd:schema>

7 Subsequent Filings that Reference this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 4/29/24  AVROBIO, Inc.                     S-4/A                 80:15M                                    Donnelley … Solutions/FA
 4/15/24  AVROBIO, Inc.                     S-4/A                 91:17M                                    Donnelley … Solutions/FA
 3/26/24  AVROBIO, Inc.                     S-4/A       3/25/24   89:18M                                    Donnelley … Solutions/FA
 3/14/24  AVROBIO, Inc.                     10-K       12/31/23   80:9.4M                                   Donnelley … Solutions/FA
 2/14/24  AVROBIO, Inc.                     S-4                   91:25M                                    Donnelley … Solutions/FA
 3/23/23  AVROBIO, Inc.                     10-K       12/31/22   82:10M                                    Donnelley … Solutions/FA
11/08/22  AVROBIO, Inc.                     S-3                    8:1.8M                                   Broadridge Fin’l So… Inc

14 Previous Filings that this Filing References

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

11/04/21  AVROBIO, Inc.                     10-Q        9/30/21   58:6.8M                                   ActiveDisclosure/FA
 5/13/21  AVROBIO, Inc.                     10-Q        3/31/21   62:5.3M                                   ActiveDisclosure/FA
 3/18/21  AVROBIO, Inc.                     10-K       12/31/20   73:9.1M                                   ActiveDisclosure/FA
11/05/20  AVROBIO, Inc.                     10-Q        9/30/20   61:6.1M                                   ActiveDisclosure/FA
 6/09/20  AVROBIO, Inc.                     8-K:5,9     6/04/20    2:66K                                    ActiveDisclosure/FA
 3/16/20  AVROBIO, Inc.                     10-K       12/31/19   85:8.4M                                   ActiveDisclosure/FA
12/20/19  AVROBIO, Inc.                     S-8        12/20/19    4:170K                                   Donnelley … Solutions/FA
 3/25/19  AVROBIO, Inc.                     S-8         3/25/19    4:96K                                    Donnelley … Solutions/FA
 3/25/19  AVROBIO, Inc.                     10-K       12/31/18   85:7.2M                                   Donnelley … Solutions/FA
12/21/18  AVROBIO, Inc.                     8-K:5,7,9  12/17/18    3:177K                                   Donnelley … Solutions/FA
 6/25/18  AVROBIO, Inc.                     8-K:5,9     6/20/18    3:148K                                   Donnelley … Solutions/FA
 6/11/18  AVROBIO, Inc.                     S-1/A¶                18:5.4M                                   Donnelley … Solutions/FA
 6/01/18  AVROBIO, Inc.                     S-1/A                  3:497K                                   Donnelley … Solutions/FA
 5/25/18  AVROBIO, Inc.                     S-1                   15:5.5M                                   Donnelley … Solutions/FA
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