SEC Info  
    Home      Search      My Interests      Help      Sign In      Please Sign In

10x Genomics, Inc. – ‘10-Q’ for 6/30/22 – ‘EX-101.DEF’

On:  Monday, 8/8/22, at 7:30pm ET   ·   As of:  8/9/22   ·   For:  6/30/22   ·   Accession #:  1770787-22-49   ·   File #:  1-39035

Previous ‘10-Q’:  ‘10-Q’ on 5/5/22 for 3/31/22   ·   Next:  ‘10-Q’ on 11/3/22 for 9/30/22   ·   Latest:  ‘10-Q’ on 11/3/23 for 9/30/23   ·   5 References:   

Find Words in Filings emoji
 
  in    Show  and   Hints

  As Of               Filer                 Filing    For·On·As Docs:Size

 8/09/22  10x Genomics, Inc.                10-Q        6/30/22   56:5.4M

Quarterly Report   —   Form 10-Q

Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-Q        Quarterly Report                                    HTML   1.08M 
 2: EX-10.1     Material Contract                                   HTML    133K 
 3: EX-31.1     Certification -- §302 - SOA'02                      HTML     22K 
 4: EX-31.2     Certification -- §302 - SOA'02                      HTML     22K 
 5: EX-32.1     Certification -- §906 - SOA'02                      HTML     19K 
 6: EX-32.2     Certification -- §906 - SOA'02                      HTML     19K 
12: R1          Cover Page                                          HTML     74K 
13: R2          Condensed Consolidated Balance Sheets               HTML    128K 
14: R3          Condensed Consolidated Statements of Operations     HTML    102K 
15: R4          Condensed Consolidated Statements of Comprehensive  HTML     46K 
                Loss                                                             
16: R5          Condensed Consolidated Statements of Stockholders?  HTML     79K 
                Equity                                                           
17: R6          Condensed Consolidated Statements of Cash Flows     HTML    120K 
18: R7          Description of Business and Basis of Presentation   HTML     24K 
19: R8          Summary of Significant Accounting Policies          HTML     30K 
20: R9          Other Financial Statement Information               HTML    107K 
21: R10         Commitments and Contingencies                       HTML     38K 
22: R11         Capital Stock                                       HTML     24K 
23: R12         Equity Incentive Plans                              HTML     48K 
24: R13         Net Loss Per Share                                  HTML     34K 
25: R14         Subsequent Events                                   HTML     20K 
26: R15         Summary of Significant Accounting Policies          HTML     43K 
                (Policies)                                                       
27: R16         Other Financial Statement Information (Tables)      HTML    120K 
28: R17         Commitments and Contingencies (Tables)              HTML     33K 
29: R18         Equity Incentive Plans (Tables)                     HTML     50K 
30: R19         Net Loss Per Share (Tables)                         HTML     33K 
31: R20         Summary of Significant Accounting Policies -        HTML     19K 
                Additional Information (Detail)                                  
32: R21         Other Financial Statement Information -             HTML     47K 
                Available-for-Sale Securities (Details)                          
33: R22         Other Financial Statement Information - Additional  HTML     36K 
                Information (Detail)                                             
34: R23         Other Financial Statement Information -             HTML     36K 
                Contractual Maturities of Marketable Securities                  
                (Details)                                                        
35: R24         Other Financial Statement Information - Schedule    HTML     28K 
                of Inventory (Detail)                                            
36: R25         Other Financial Statement Information - Schedule    HTML     34K 
                of Accrued Compensation and Related Benefits                     
                (Detail)                                                         
37: R26         Other Financial Statement Information - Schedule    HTML     40K 
                of Accrued Expense And Other Current Liabilities                 
                (Detail)                                                         
38: R27         Other Financial Statement Information - Schedule    HTML     25K 
                of Changes in the Reserve for Product Warranties                 
                (Detail)                                                         
39: R28         Other Financial Statement Information - Revenue     HTML     22K 
                Recognition (Details)                                            
40: R29         Other Financial Statement Information - Schedule    HTML     30K 
                of Revenue by Source (Detail)                                    
41: R30         Other Financial Statement Information - Schedule    HTML     35K 
                of Revenue by Geographic Region (Details)                        
42: R31         Commitments and Contingencies - Additional          HTML     24K 
                Information (Detail)                                             
43: R32         Commitments and Contingencies - Summary of          HTML     40K 
                Company's Operating Lease Liabilities (Detail)                   
44: R33         Commitments and Contingencies - Summary of          HTML     22K 
                Additional Information Related to Operating Leases               
                (Detail)                                                         
45: R34         Capital Stock - Additional Information (Detail)     HTML     32K 
46: R35         Equity Incentive Plans - Additional Information     HTML     29K 
                (Detail)                                                         
47: R36         Equity Incentive Plans - Recorded Stock-Based       HTML     28K 
                Compensation Expense in the Condensed Consolidated               
                Statement of Operations (Details)                                
48: R37         Equity Incentive Plans - Summary of RSU Activity    HTML     41K 
                (Detail)                                                         
49: R38         Equity Incentive Plans - Summary of Company's       HTML     41K 
                Stock Option Activity (Details)                                  
50: R39         Net Loss Per Share - Shares of Common Stock         HTML     35K 
                Equivalents Were Excluded From The Computation of                
                Diluted Net Loss Per Share (Details)                             
51: R40         Subsequent Events (Details)                         HTML     26K 
54: XML         IDEA XML File -- Filing Summary                      XML     95K 
52: XML         XBRL Instance -- txg-20220630_htm                    XML   1.08M 
53: EXCEL       IDEA Workbook of Financial Reports                  XLSX     82K 
 8: EX-101.CAL  XBRL Calculations -- txg-20220630_cal                XML    179K 
 9: EX-101.DEF  XBRL Definitions -- txg-20220630_def                 XML    258K 
10: EX-101.LAB  XBRL Labels -- txg-20220630_lab                      XML   1.06M 
11: EX-101.PRE  XBRL Presentations -- txg-20220630_pre               XML    571K 
 7: EX-101.SCH  XBRL Schema -- txg-20220630                          XSD     99K 
55: JSON        XBRL Instance as JSON Data -- MetaLinks              291±   441K 
56: ZIP         XBRL Zipped Folder -- 0001770787-22-000049-xbrl      Zip    496K 


‘EX-101.DEF’   —   XBRL Definitions — txg-20220630_def


This Exhibit is an XBRL XML File.


                                                                                                                                                                                
<?xml version="1.0" encoding="windows-1252"?>
<!-- XBRL Document Created with Wdesk from Workiva -->
<!-- Copyright 2022 Workiva -->
<!-- r:7ea11a44-0927-4732-8014-55dc67ee4c4e,g:5b179022-b75e-468f-b9e4-732fb75a9a81 -->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
<link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
<link:roleRef roleURI="http://www.10xgenomics.com/role/CoverPage" xlink:type="simple" xlink:href="txg-20220630.xsd#CoverPage"/>
<link:definitionLink xlink:role="http://www.10xgenomics.com/role/CoverPage" xlink:type="extended" id="i8a6d722a3e0646c58e54139046965cbc_CoverPage">
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityInformationLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_00d683f9-4f90-4572-aee0-859b07e658ad" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentType"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_DocumentType_00d683f9-4f90-4572-aee0-859b07e658ad" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_DocumentQuarterlyReport_c7a746d5-1d7f-46ba-9dc7-96b47cd67c7f" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentQuarterlyReport"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_DocumentQuarterlyReport_c7a746d5-1d7f-46ba-9dc7-96b47cd67c7f" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_66216917-d424-4b5d-a37d-e5b98a73d665" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentPeriodEndDate"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_DocumentPeriodEndDate_66216917-d424-4b5d-a37d-e5b98a73d665" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_DocumentTransitionReport_629b33c4-3373-441a-8f60-41ba3a233a0d" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentTransitionReport"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_DocumentTransitionReport_629b33c4-3373-441a-8f60-41ba3a233a0d" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_20efac46-0164-4eef-b444-cdedc3c42ca7" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityFileNumber"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_EntityFileNumber_20efac46-0164-4eef-b444-cdedc3c42ca7" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_a689a14a-c72a-4d74-b9f1-6541d198d78a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityRegistrantName"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_EntityRegistrantName_a689a14a-c72a-4d74-b9f1-6541d198d78a" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_af8874e2-0918-4aae-a1e1-8a0bc2816dcb" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityIncorporationStateCountryCode"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_EntityIncorporationStateCountryCode_af8874e2-0918-4aae-a1e1-8a0bc2816dcb" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_9f31089c-fad3-4ce7-99ad-e129208425de" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityTaxIdentificationNumber"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_EntityTaxIdentificationNumber_9f31089c-fad3-4ce7-99ad-e129208425de" xlink:type="arc" order="7"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_0bdbc766-d046-46f4-9089-f33ad4f17a39" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressAddressLine1"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_EntityAddressAddressLine1_0bdbc766-d046-46f4-9089-f33ad4f17a39" xlink:type="arc" order="8"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_d67d5025-c7f6-4307-a627-7e7245fb1283" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressCityOrTown"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_EntityAddressCityOrTown_d67d5025-c7f6-4307-a627-7e7245fb1283" xlink:type="arc" order="9"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_c551da36-f321-41b7-90c3-8c230f4c9e22" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressStateOrProvince"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_EntityAddressStateOrProvince_c551da36-f321-41b7-90c3-8c230f4c9e22" xlink:type="arc" order="10"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_eac03f40-57fd-4573-bc9a-9f2a6e92a6f6" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressPostalZipCode"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_EntityAddressPostalZipCode_eac03f40-57fd-4573-bc9a-9f2a6e92a6f6" xlink:type="arc" order="11"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_e84fc986-8290-4858-b44a-acd257a5e899" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CityAreaCode"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_CityAreaCode_e84fc986-8290-4858-b44a-acd257a5e899" xlink:type="arc" order="12"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_ae260f3b-e196-4a71-a083-654ef9110ddb" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LocalPhoneNumber"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_LocalPhoneNumber_ae260f3b-e196-4a71-a083-654ef9110ddb" xlink:type="arc" order="13"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_ef481a63-5149-434a-989d-9db7fadaf0ab" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_Security12bTitle"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_Security12bTitle_ef481a63-5149-434a-989d-9db7fadaf0ab" xlink:type="arc" order="14"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_8325605e-7a35-45ce-81a2-7297c8940ae1" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_TradingSymbol"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_TradingSymbol_8325605e-7a35-45ce-81a2-7297c8940ae1" xlink:type="arc" order="15"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_50170117-e85c-4368-ba69-14fed213af67" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_SecurityExchangeName"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_SecurityExchangeName_50170117-e85c-4368-ba69-14fed213af67" xlink:type="arc" order="16"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_0a8dd4ac-f1e6-43ca-b479-bf986b303fe0" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCurrentReportingStatus"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_EntityCurrentReportingStatus_0a8dd4ac-f1e6-43ca-b479-bf986b303fe0" xlink:type="arc" order="17"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityInteractiveDataCurrent_7b28eb2a-a8d6-4c1f-ad75-82880f7c6c8d" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityInteractiveDataCurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_EntityInteractiveDataCurrent_7b28eb2a-a8d6-4c1f-ad75-82880f7c6c8d" xlink:type="arc" order="18"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_e2a6bbcb-31e9-47b1-903f-2c03e3ff9a2a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityFilerCategory"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_EntityFilerCategory_e2a6bbcb-31e9-47b1-903f-2c03e3ff9a2a" xlink:type="arc" order="19"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness_2d8eeab9-1969-4b96-bcd8-cd172b7fb97f" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntitySmallBusiness"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_EntitySmallBusiness_2d8eeab9-1969-4b96-bcd8-cd172b7fb97f" xlink:type="arc" order="20"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_ccba5937-4ada-4d93-bd30-d41181fc43db" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityEmergingGrowthCompany"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_EntityEmergingGrowthCompany_ccba5937-4ada-4d93-bd30-d41181fc43db" xlink:type="arc" order="21"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany_cbb59aa3-a9fe-4eb8-9bde-f5c7241eb367" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityShellCompany"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_EntityShellCompany_cbb59aa3-a9fe-4eb8-9bde-f5c7241eb367" xlink:type="arc" order="22"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_51a81c06-25bb-4818-81e1-d1afc6bb7590" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCommonStockSharesOutstanding"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_51a81c06-25bb-4818-81e1-d1afc6bb7590" xlink:type="arc" order="23"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_b078f524-9784-4aa7-a0fa-c075e3f0e0a2" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_AmendmentFlag"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_AmendmentFlag_b078f524-9784-4aa7-a0fa-c075e3f0e0a2" xlink:type="arc" order="24"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_32edd658-626d-460a-80ac-96ce32a73997" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentFiscalYearFocus"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_DocumentFiscalYearFocus_32edd658-626d-460a-80ac-96ce32a73997" xlink:type="arc" order="25"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_1e187812-8a9b-4a25-b770-07666bb9c40f" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentFiscalPeriodFocus"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_DocumentFiscalPeriodFocus_1e187812-8a9b-4a25-b770-07666bb9c40f" xlink:type="arc" order="26"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_c7b6327c-65df-46a8-bd47-956f14b8f98e" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CurrentFiscalYearEndDate"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_CurrentFiscalYearEndDate_c7b6327c-65df-46a8-bd47-956f14b8f98e" xlink:type="arc" order="27"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_54777147-ce5b-4b27-8018-e0b4791f7b2c" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCentralIndexKey"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_EntityCentralIndexKey_54777147-ce5b-4b27-8018-e0b4791f7b2c" xlink:type="arc" order="28"/>
<link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationTable_fe9350bd-bd04-4d8a-b48a-5f4edf4a0f3a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentInformationTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_dei_EntityInformationLineItems_14b6bbe1-e657-46cf-a289-7ac00959284c" xlink:to="loc_dei_DocumentInformationTable_fe9350bd-bd04-4d8a-b48a-5f4edf4a0f3a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_8e9aa376-7767-4de6-bdb2-3576e2b3ccf1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_DocumentInformationTable_fe9350bd-bd04-4d8a-b48a-5f4edf4a0f3a" xlink:to="loc_us-gaap_StatementClassOfStockAxis_8e9aa376-7767-4de6-bdb2-3576e2b3ccf1" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_8e9aa376-7767-4de6-bdb2-3576e2b3ccf1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_8e9aa376-7767-4de6-bdb2-3576e2b3ccf1" xlink:to="loc_us-gaap_ClassOfStockDomain_8e9aa376-7767-4de6-bdb2-3576e2b3ccf1_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_ff611534-082b-4f23-82e9-9476614894d5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_8e9aa376-7767-4de6-bdb2-3576e2b3ccf1" xlink:to="loc_us-gaap_ClassOfStockDomain_ff611534-082b-4f23-82e9-9476614894d5" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_ddaa8b34-92e5-4399-a0b9-d0164414ab73" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_ff611534-082b-4f23-82e9-9476614894d5" xlink:to="loc_us-gaap_CommonClassAMember_ddaa8b34-92e5-4399-a0b9-d0164414ab73" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_34ea15f3-72eb-4a1b-8f20-e3a1c14df107" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassBMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_ff611534-082b-4f23-82e9-9476614894d5" xlink:to="loc_us-gaap_CommonClassBMember_34ea15f3-72eb-4a1b-8f20-e3a1c14df107" xlink:type="arc" order="1"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.10xgenomics.com/role/CondensedConsolidatedStatementsofStockholdersEquity" xlink:type="simple" xlink:href="txg-20220630.xsd#CondensedConsolidatedStatementsofStockholdersEquity"/>
<link:definitionLink xlink:role="http://www.10xgenomics.com/role/CondensedConsolidatedStatementsofStockholdersEquity" xlink:type="extended" id="ibe59545839cc419eb326f2df4040e378_CondensedConsolidatedStatementsofStockholdersEquity">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_5dabd3d6-180e-43b5-8c54-d3dcebedf526" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4470a4c2-5596-42eb-9057-5c75c617ff71" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_5dabd3d6-180e-43b5-8c54-d3dcebedf526" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4470a4c2-5596-42eb-9057-5c75c617ff71" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_c37576e8-7dd0-4754-9a3f-3ecfabc90c21" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharesOutstanding"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4470a4c2-5596-42eb-9057-5c75c617ff71" xlink:to="loc_us-gaap_SharesOutstanding_c37576e8-7dd0-4754-9a3f-3ecfabc90c21" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_1b9d49ed-8d8b-495b-b156-4d2d0d2f147a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4470a4c2-5596-42eb-9057-5c75c617ff71" xlink:to="loc_us-gaap_StockholdersEquity_1b9d49ed-8d8b-495b-b156-4d2d0d2f147a" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_6995f147-1fd9-4fb5-9637-2322b00e52b4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4470a4c2-5596-42eb-9057-5c75c617ff71" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_6995f147-1fd9-4fb5-9637-2322b00e52b4" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_f80d7bbf-aff4-4e73-a2e2-70fcd4243678" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4470a4c2-5596-42eb-9057-5c75c617ff71" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_f80d7bbf-aff4-4e73-a2e2-70fcd4243678" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_txg_AdjustmentsToAdditionalPaidInCapitalVestingOfSharesIncludingEarlyExerciseOfOptions_3beea6c5-bc1d-4012-b94e-a5926087e7f9" xlink:href="txg-20220630.xsd#txg_AdjustmentsToAdditionalPaidInCapitalVestingOfSharesIncludingEarlyExerciseOfOptions"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4470a4c2-5596-42eb-9057-5c75c617ff71" xlink:to="loc_txg_AdjustmentsToAdditionalPaidInCapitalVestingOfSharesIncludingEarlyExerciseOfOptions_3beea6c5-bc1d-4012-b94e-a5926087e7f9" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_257b9005-9d30-4e58-b994-86a0ad137248" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4470a4c2-5596-42eb-9057-5c75c617ff71" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_257b9005-9d30-4e58-b994-86a0ad137248" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_93d8b49a-f292-4737-ba76-6dc2c8aeceee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4470a4c2-5596-42eb-9057-5c75c617ff71" xlink:to="loc_us-gaap_NetIncomeLoss_93d8b49a-f292-4737-ba76-6dc2c8aeceee" xlink:type="arc" order="7"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_7d50580e-f353-403e-be46-9c9e0d51eb91" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4470a4c2-5596-42eb-9057-5c75c617ff71" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_7d50580e-f353-403e-be46-9c9e0d51eb91" xlink:type="arc" order="8"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_a6f78d72-980c-4e7c-8f67-d0ad341613fd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharesOutstanding"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_1ce5f87e-4d0b-4038-ad24-92db9d3080be" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_3d60015f-e94d-47a5-a2c8-68bbeb71f002" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_5dabd3d6-180e-43b5-8c54-d3dcebedf526" xlink:to="loc_us-gaap_StatementTable_3d60015f-e94d-47a5-a2c8-68bbeb71f002" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_fc40f9c4-d715-4aeb-875e-3174bb393bc5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_3d60015f-e94d-47a5-a2c8-68bbeb71f002" xlink:to="loc_us-gaap_StatementClassOfStockAxis_fc40f9c4-d715-4aeb-875e-3174bb393bc5" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_fc40f9c4-d715-4aeb-875e-3174bb393bc5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_fc40f9c4-d715-4aeb-875e-3174bb393bc5" xlink:to="loc_us-gaap_ClassOfStockDomain_fc40f9c4-d715-4aeb-875e-3174bb393bc5_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_ee9076a4-1797-4dd7-8885-cc41c85fbc88" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_fc40f9c4-d715-4aeb-875e-3174bb393bc5" xlink:to="loc_us-gaap_ClassOfStockDomain_ee9076a4-1797-4dd7-8885-cc41c85fbc88" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_0463652e-d8c1-403b-bba2-e38e100bf915" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_ee9076a4-1797-4dd7-8885-cc41c85fbc88" xlink:to="loc_us-gaap_CommonClassAMember_0463652e-d8c1-403b-bba2-e38e100bf915" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_6acc2397-99a4-4fc2-aa40-acf097e7a8f0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_3d60015f-e94d-47a5-a2c8-68bbeb71f002" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_6acc2397-99a4-4fc2-aa40-acf097e7a8f0" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_6acc2397-99a4-4fc2-aa40-acf097e7a8f0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_6acc2397-99a4-4fc2-aa40-acf097e7a8f0" xlink:to="loc_us-gaap_EquityComponentDomain_6acc2397-99a4-4fc2-aa40-acf097e7a8f0_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_75b1ffe7-6be4-43ef-97f7-79deb55b0eb1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_6acc2397-99a4-4fc2-aa40-acf097e7a8f0" xlink:to="loc_us-gaap_EquityComponentDomain_75b1ffe7-6be4-43ef-97f7-79deb55b0eb1" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_9ee80fba-226a-4010-8e0f-a563832a79b1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_75b1ffe7-6be4-43ef-97f7-79deb55b0eb1" xlink:to="loc_us-gaap_CommonStockMember_9ee80fba-226a-4010-8e0f-a563832a79b1" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_5d9853ce-b133-4c35-8f1a-515e3aae9b87" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_75b1ffe7-6be4-43ef-97f7-79deb55b0eb1" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_5d9853ce-b133-4c35-8f1a-515e3aae9b87" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_c06bfc9c-db3d-451d-ac95-7ddbace05f1c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_75b1ffe7-6be4-43ef-97f7-79deb55b0eb1" xlink:to="loc_us-gaap_RetainedEarningsMember_c06bfc9c-db3d-451d-ac95-7ddbace05f1c" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_90a77051-0f0f-4a53-9d65-486bfc0972e4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_75b1ffe7-6be4-43ef-97f7-79deb55b0eb1" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_90a77051-0f0f-4a53-9d65-486bfc0972e4" xlink:type="arc" order="3"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.10xgenomics.com/role/OtherFinancialStatementInformationAvailableforSaleSecuritiesDetails" xlink:type="simple" xlink:href="txg-20220630.xsd#OtherFinancialStatementInformationAvailableforSaleSecuritiesDetails"/>
<link:definitionLink xlink:role="http://www.10xgenomics.com/role/OtherFinancialStatementInformationAvailableforSaleSecuritiesDetails" xlink:type="extended" id="i6db47e52457a44869398e46e40c97db6_OtherFinancialStatementInformationAvailableforSaleSecuritiesDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesLineItems_49134d8a-ab6f-459c-8f1f-c9f5c2eb7593" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MarketableSecuritiesLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsAtCarryingValue_410ab322-c823-46a6-91d9-ea4bd809b904" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MoneyMarketFundsAtCarryingValue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_49134d8a-ab6f-459c-8f1f-c9f5c2eb7593" xlink:to="loc_us-gaap_MoneyMarketFundsAtCarryingValue_410ab322-c823-46a6-91d9-ea4bd809b904" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_0224ea9f-5e0f-4dd6-87f2-09fd21220a22" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_49134d8a-ab6f-459c-8f1f-c9f5c2eb7593" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_0224ea9f-5e0f-4dd6-87f2-09fd21220a22" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_0812eea1-3202-411b-ad63-affb3bc96887" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_49134d8a-ab6f-459c-8f1f-c9f5c2eb7593" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_0812eea1-3202-411b-ad63-affb3bc96887" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_59571768-98d1-4066-b200-6e65165b42d3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_49134d8a-ab6f-459c-8f1f-c9f5c2eb7593" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_59571768-98d1-4066-b200-6e65165b42d3" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_a735377d-69c8-4e67-921d-d334d15a2ef1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_49134d8a-ab6f-459c-8f1f-c9f5c2eb7593" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_a735377d-69c8-4e67-921d-d334d15a2ef1" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_txg_DebtSecuritiesAvailableForSaleAmortizedCostIncludingMoneyMarketFunds_c0ff955a-6f4a-4b51-91cb-ade4415ac6bc" xlink:href="txg-20220630.xsd#txg_DebtSecuritiesAvailableForSaleAmortizedCostIncludingMoneyMarketFunds"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_49134d8a-ab6f-459c-8f1f-c9f5c2eb7593" xlink:to="loc_txg_DebtSecuritiesAvailableForSaleAmortizedCostIncludingMoneyMarketFunds_c0ff955a-6f4a-4b51-91cb-ade4415ac6bc" xlink:type="arc" order="5"/>
<link:loc xlink:type="locator" xlink:label="loc_txg_DebtSecuritiesAvailableForSaleIncludingMoneyMarketFunds_3ec09eed-d5d3-469b-8e49-60176843536d" xlink:href="txg-20220630.xsd#txg_DebtSecuritiesAvailableForSaleIncludingMoneyMarketFunds"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_49134d8a-ab6f-459c-8f1f-c9f5c2eb7593" xlink:to="loc_txg_DebtSecuritiesAvailableForSaleIncludingMoneyMarketFunds_3ec09eed-d5d3-469b-8e49-60176843536d" xlink:type="arc" order="6"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesTable_1431d81d-3e80-4b20-98ee-0ee70477a7ae" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MarketableSecuritiesTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_49134d8a-ab6f-459c-8f1f-c9f5c2eb7593" xlink:to="loc_us-gaap_MarketableSecuritiesTable_1431d81d-3e80-4b20-98ee-0ee70477a7ae" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_59a807f2-aa1c-4d68-bd86-2267bac65111" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_MarketableSecuritiesTable_1431d81d-3e80-4b20-98ee-0ee70477a7ae" xlink:to="loc_us-gaap_FinancialInstrumentAxis_59a807f2-aa1c-4d68-bd86-2267bac65111" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_59a807f2-aa1c-4d68-bd86-2267bac65111_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_59a807f2-aa1c-4d68-bd86-2267bac65111" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_59a807f2-aa1c-4d68-bd86-2267bac65111_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_8b7289db-f224-45f8-8915-bd1496665c95" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_59a807f2-aa1c-4d68-bd86-2267bac65111" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_8b7289db-f224-45f8-8915-bd1496665c95" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_234661b0-dfd4-42aa-835d-fa96d5724c93" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MoneyMarketFundsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_8b7289db-f224-45f8-8915-bd1496665c95" xlink:to="loc_us-gaap_MoneyMarketFundsMember_234661b0-dfd4-42aa-835d-fa96d5724c93" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_8e902c82-7f7e-4287-bad1-58622e82b7f0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_8b7289db-f224-45f8-8915-bd1496665c95" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_8e902c82-7f7e-4287-bad1-58622e82b7f0" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentDebtSecuritiesMember_2c587874-0132-4cb5-8b77-9daa6e8d7846" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USGovernmentDebtSecuritiesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_8b7289db-f224-45f8-8915-bd1496665c95" xlink:to="loc_us-gaap_USGovernmentDebtSecuritiesMember_2c587874-0132-4cb5-8b77-9daa6e8d7846" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetBackedSecuritiesMember_fc950a62-cd71-449d-af49-baf85331714e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetBackedSecuritiesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_8b7289db-f224-45f8-8915-bd1496665c95" xlink:to="loc_us-gaap_AssetBackedSecuritiesMember_fc950a62-cd71-449d-af49-baf85331714e" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_b996135b-130c-4e1b-9049-1d20eb7118b7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_MarketableSecuritiesTable_1431d81d-3e80-4b20-98ee-0ee70477a7ae" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_b996135b-130c-4e1b-9049-1d20eb7118b7" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_b996135b-130c-4e1b-9049-1d20eb7118b7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_b996135b-130c-4e1b-9049-1d20eb7118b7" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_b996135b-130c-4e1b-9049-1d20eb7118b7_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_1157475d-7978-4d83-b140-4376bccf1238" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_b996135b-130c-4e1b-9049-1d20eb7118b7" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_1157475d-7978-4d83-b140-4376bccf1238" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_ff79b8c3-764d-4e35-815c-46066c3c5b0c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel1Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_1157475d-7978-4d83-b140-4376bccf1238" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_ff79b8c3-764d-4e35-815c-46066c3c5b0c" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_87fffee1-6640-4dbe-b648-08e7daa62d67" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel2Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_1157475d-7978-4d83-b140-4376bccf1238" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_87fffee1-6640-4dbe-b648-08e7daa62d67" xlink:type="arc" order="1"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.10xgenomics.com/role/OtherFinancialStatementInformationAdditionalInformationDetail" xlink:type="simple" xlink:href="txg-20220630.xsd#OtherFinancialStatementInformationAdditionalInformationDetail"/>
<link:definitionLink xlink:role="http://www.10xgenomics.com/role/OtherFinancialStatementInformationAdditionalInformationDetail" xlink:type="extended" id="ia0e1392bed8443c2957bec6032646ab9_OtherFinancialStatementInformationAdditionalInformationDetail">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskLineItems_c753f28e-bf68-46b1-8322-c02c2de39360" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsAtCarryingValue_91e95b75-806d-48a0-955a-2cfba7f46471" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MoneyMarketFundsAtCarryingValue"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_c753f28e-bf68-46b1-8322-c02c2de39360" xlink:to="loc_us-gaap_MoneyMarketFundsAtCarryingValue_91e95b75-806d-48a0-955a-2cfba7f46471" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligation_2b8b58a0-c885-43b5-99e4-f8bc7cb62ef7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligation"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_c753f28e-bf68-46b1-8322-c02c2de39360" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligation_2b8b58a0-c885-43b5-99e4-f8bc7cb62ef7" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_a4ef2c9c-e77b-4d61-98ae-f7c533211616" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_c753f28e-bf68-46b1-8322-c02c2de39360" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_a4ef2c9c-e77b-4d61-98ae-f7c533211616" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiability_2f569149-f720-4e55-89cf-3a5c6f4c8195" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiability"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_c753f28e-bf68-46b1-8322-c02c2de39360" xlink:to="loc_us-gaap_ContractWithCustomerLiability_2f569149-f720-4e55-89cf-3a5c6f4c8195" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_e12f55f2-e1e0-4a41-bcd3-ce9b1e625a85" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiabilityRevenueRecognized"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_c753f28e-bf68-46b1-8322-c02c2de39360" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_e12f55f2-e1e0-4a41-bcd3-ce9b1e625a85" xlink:type="arc" order="4"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTable_39e87840-622e-4ec2-90d0-16da841776f9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_c753f28e-bf68-46b1-8322-c02c2de39360" xlink:to="loc_us-gaap_ConcentrationRiskTable_39e87840-622e-4ec2-90d0-16da841776f9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_b66a5c05-8f18-4219-9fa2-318c60201983" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_39e87840-622e-4ec2-90d0-16da841776f9" xlink:to="loc_srt_ProductOrServiceAxis_b66a5c05-8f18-4219-9fa2-318c60201983" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_b66a5c05-8f18-4219-9fa2-318c60201983_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_b66a5c05-8f18-4219-9fa2-318c60201983" xlink:to="loc_srt_ProductsAndServicesDomain_b66a5c05-8f18-4219-9fa2-318c60201983_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_7b054f88-aa96-4783-8648-62a4c667986f" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_b66a5c05-8f18-4219-9fa2-318c60201983" xlink:to="loc_srt_ProductsAndServicesDomain_7b054f88-aa96-4783-8648-62a4c667986f" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_txg_ProductsAndServicesExcludingGrantRevenueMember_55cb91ab-2d19-4939-9775-da22be2656d9" xlink:href="txg-20220630.xsd#txg_ProductsAndServicesExcludingGrantRevenueMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_7b054f88-aa96-4783-8648-62a4c667986f" xlink:to="loc_txg_ProductsAndServicesExcludingGrantRevenueMember_55cb91ab-2d19-4939-9775-da22be2656d9" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAxis_37644509-9437-48ee-9f34-37a0c9842956" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_39e87840-622e-4ec2-90d0-16da841776f9" xlink:to="loc_us-gaap_CashAndCashEquivalentsAxis_37644509-9437-48ee-9f34-37a0c9842956" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_37644509-9437-48ee-9f34-37a0c9842956_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_37644509-9437-48ee-9f34-37a0c9842956" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_37644509-9437-48ee-9f34-37a0c9842956_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_869a8272-bcc7-43c2-89c5-25f6af9c17d3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_37644509-9437-48ee-9f34-37a0c9842956" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_869a8272-bcc7-43c2-89c5-25f6af9c17d3" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_1a0338dd-d6ca-4ff6-8117-0afb56559ce9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MoneyMarketFundsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_869a8272-bcc7-43c2-89c5-25f6af9c17d3" xlink:to="loc_us-gaap_MoneyMarketFundsMember_1a0338dd-d6ca-4ff6-8117-0afb56559ce9" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_66975b6b-af72-446a-9f61-4c2efc361152" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_39e87840-622e-4ec2-90d0-16da841776f9" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_66975b6b-af72-446a-9f61-4c2efc361152" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_66975b6b-af72-446a-9f61-4c2efc361152_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_66975b6b-af72-446a-9f61-4c2efc361152" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_66975b6b-af72-446a-9f61-4c2efc361152_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_0727ceb1-5bb2-4c0e-a552-7de13a17c963" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_66975b6b-af72-446a-9f61-4c2efc361152" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_0727ceb1-5bb2-4c0e-a552-7de13a17c963" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_a8416293-0f62-4bb6-9a8b-46e1c44399dd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel1Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_0727ceb1-5bb2-4c0e-a552-7de13a17c963" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_a8416293-0f62-4bb6-9a8b-46e1c44399dd" xlink:type="arc" order="0"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.10xgenomics.com/role/OtherFinancialStatementInformationRevenueRecognitionDetails" xlink:type="simple" xlink:href="txg-20220630.xsd#OtherFinancialStatementInformationRevenueRecognitionDetails"/>
<link:definitionLink xlink:role="http://www.10xgenomics.com/role/OtherFinancialStatementInformationRevenueRecognitionDetails" xlink:type="extended" id="i2341c4730ee541b18393fd4e4d22d8bd_OtherFinancialStatementInformationRevenueRecognitionDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_e618199c-ef20-4280-9941-0447055eabb9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1_8068046a-c47b-4d1b-b1f8-cbada6a73a68" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_e618199c-ef20-4280-9941-0447055eabb9" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1_8068046a-c47b-4d1b-b1f8-cbada6a73a68" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_b1972064-f337-42d4-838b-f680dadd0385" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_e618199c-ef20-4280-9941-0447055eabb9" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_b1972064-f337-42d4-838b-f680dadd0385" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionStartDateAxis_86b772c2-c47d-4ccc-94b7-e1641f636c4e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionStartDateAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_b1972064-f337-42d4-838b-f680dadd0385" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionStartDateAxis_86b772c2-c47d-4ccc-94b7-e1641f636c4e" xlink:type="arc" order="1"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.10xgenomics.com/role/OtherFinancialStatementInformationRevenueRecognitionDetails_1" xlink:type="simple" xlink:href="txg-20220630.xsd#OtherFinancialStatementInformationRevenueRecognitionDetails_1"/>
<link:definitionLink xlink:role="http://www.10xgenomics.com/role/OtherFinancialStatementInformationRevenueRecognitionDetails_1" xlink:type="extended" id="i3b7aa721759a483086c3aedf6c733ee6_OtherFinancialStatementInformationRevenueRecognitionDetails_1">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_e618199c-ef20-4280-9941-0447055eabb9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1_8068046a-c47b-4d1b-b1f8-cbada6a73a68" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_e618199c-ef20-4280-9941-0447055eabb9" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1_8068046a-c47b-4d1b-b1f8-cbada6a73a68" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_b1972064-f337-42d4-838b-f680dadd0385" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_e618199c-ef20-4280-9941-0447055eabb9" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_b1972064-f337-42d4-838b-f680dadd0385" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.10xgenomics.com/role/OtherFinancialStatementInformationScheduleofRevenuebySourceDetail" xlink:type="simple" xlink:href="txg-20220630.xsd#OtherFinancialStatementInformationScheduleofRevenuebySourceDetail"/>
<link:definitionLink xlink:role="http://www.10xgenomics.com/role/OtherFinancialStatementInformationScheduleofRevenuebySourceDetail" xlink:type="extended" id="i058ffe91966f4bbfbe191f87987ba187_OtherFinancialStatementInformationScheduleofRevenuebySourceDetail">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_41407ceb-9438-4bd8-b493-5257425d420f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_c317bfd0-b293-49a4-8da2-816b7cb85a87" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_41407ceb-9438-4bd8-b493-5257425d420f" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_c317bfd0-b293-49a4-8da2-816b7cb85a87" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_bba608ee-2da3-49da-9228-ada4186d196d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_41407ceb-9438-4bd8-b493-5257425d420f" xlink:to="loc_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_bba608ee-2da3-49da-9228-ada4186d196d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_46cd3bbd-b12c-47f6-9c2a-514f6c3ba7cc" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_bba608ee-2da3-49da-9228-ada4186d196d" xlink:to="loc_srt_ProductOrServiceAxis_46cd3bbd-b12c-47f6-9c2a-514f6c3ba7cc" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_46cd3bbd-b12c-47f6-9c2a-514f6c3ba7cc_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_46cd3bbd-b12c-47f6-9c2a-514f6c3ba7cc" xlink:to="loc_srt_ProductsAndServicesDomain_46cd3bbd-b12c-47f6-9c2a-514f6c3ba7cc_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_a7efb276-82db-452a-8370-667e6ec6582f" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_46cd3bbd-b12c-47f6-9c2a-514f6c3ba7cc" xlink:to="loc_srt_ProductsAndServicesDomain_a7efb276-82db-452a-8370-667e6ec6582f" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_txg_InstrumentsMember_396d355b-2039-4122-a6d0-dfac5fde4b12" xlink:href="txg-20220630.xsd#txg_InstrumentsMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_a7efb276-82db-452a-8370-667e6ec6582f" xlink:to="loc_txg_InstrumentsMember_396d355b-2039-4122-a6d0-dfac5fde4b12" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_txg_ConsumablesMember_14119e98-96bf-44fc-8d62-c9726459615d" xlink:href="txg-20220630.xsd#txg_ConsumablesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_a7efb276-82db-452a-8370-667e6ec6582f" xlink:to="loc_txg_ConsumablesMember_14119e98-96bf-44fc-8d62-c9726459615d" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ServiceMember_956effbb-8dc7-45fb-bd0f-c0087ffea867" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ServiceMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_a7efb276-82db-452a-8370-667e6ec6582f" xlink:to="loc_us-gaap_ServiceMember_956effbb-8dc7-45fb-bd0f-c0087ffea867" xlink:type="arc" order="2"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.10xgenomics.com/role/OtherFinancialStatementInformationScheduleofRevenuebyGeographicRegionDetails" xlink:type="simple" xlink:href="txg-20220630.xsd#OtherFinancialStatementInformationScheduleofRevenuebyGeographicRegionDetails"/>
<link:definitionLink xlink:role="http://www.10xgenomics.com/role/OtherFinancialStatementInformationScheduleofRevenuebyGeographicRegionDetails" xlink:type="extended" id="i8f5c0947d4bb473ab271524134055932_OtherFinancialStatementInformationScheduleofRevenuebyGeographicRegionDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_ab2d47b6-c022-4930-81ef-375d0a9f6aa1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_fc200ac7-6834-47f6-923a-4018919b1f2f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_ab2d47b6-c022-4930-81ef-375d0a9f6aa1" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_fc200ac7-6834-47f6-923a-4018919b1f2f" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_95495d79-3d1e-41b8-952e-88f0662419f2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_ab2d47b6-c022-4930-81ef-375d0a9f6aa1" xlink:to="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_95495d79-3d1e-41b8-952e-88f0662419f2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_ecc6e7ac-0abf-4c6b-b816-ab1c5a118217" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_95495d79-3d1e-41b8-952e-88f0662419f2" xlink:to="loc_srt_StatementGeographicalAxis_ecc6e7ac-0abf-4c6b-b816-ab1c5a118217" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_ecc6e7ac-0abf-4c6b-b816-ab1c5a118217_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_ecc6e7ac-0abf-4c6b-b816-ab1c5a118217" xlink:to="loc_srt_SegmentGeographicalDomain_ecc6e7ac-0abf-4c6b-b816-ab1c5a118217_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_44346991-97b5-4dc1-9cdb-555766513fee" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_ecc6e7ac-0abf-4c6b-b816-ab1c5a118217" xlink:to="loc_srt_SegmentGeographicalDomain_44346991-97b5-4dc1-9cdb-555766513fee" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_country_US_5c926bd3-68f6-461b-afdb-47740b344d43" xlink:href="https://xbrl.sec.gov/country/2022/country-2022.xsd#country_US"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_44346991-97b5-4dc1-9cdb-555766513fee" xlink:to="loc_country_US_5c926bd3-68f6-461b-afdb-47740b344d43" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EMEAMember_7decc095-a911-464b-993e-aaa7446de100" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EMEAMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_44346991-97b5-4dc1-9cdb-555766513fee" xlink:to="loc_us-gaap_EMEAMember_7decc095-a911-464b-993e-aaa7446de100" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_country_CN_3b0fa885-13f4-4f83-ae78-217b21f86357" xlink:href="https://xbrl.sec.gov/country/2022/country-2022.xsd#country_CN"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_44346991-97b5-4dc1-9cdb-555766513fee" xlink:to="loc_country_CN_3b0fa885-13f4-4f83-ae78-217b21f86357" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_txg_AsiaPacificExcludingChinaMember_0f59eb71-a07d-4e0c-96be-e399077282e2" xlink:href="txg-20220630.xsd#txg_AsiaPacificExcludingChinaMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_44346991-97b5-4dc1-9cdb-555766513fee" xlink:to="loc_txg_AsiaPacificExcludingChinaMember_0f59eb71-a07d-4e0c-96be-e399077282e2" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_txg_NorthAmericaExcludingUnitedStatesMember_22942c59-70cc-480f-9fc8-b764ada3666a" xlink:href="txg-20220630.xsd#txg_NorthAmericaExcludingUnitedStatesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_44346991-97b5-4dc1-9cdb-555766513fee" xlink:to="loc_txg_NorthAmericaExcludingUnitedStatesMember_22942c59-70cc-480f-9fc8-b764ada3666a" xlink:type="arc" order="4"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.10xgenomics.com/role/CommitmentsandContingenciesAdditionalInformationDetail" xlink:type="simple" xlink:href="txg-20220630.xsd#CommitmentsandContingenciesAdditionalInformationDetail"/>
<link:definitionLink xlink:role="http://www.10xgenomics.com/role/CommitmentsandContingenciesAdditionalInformationDetail" xlink:type="extended" id="ia67450d52226465c85d87523c47004e9_CommitmentsandContingenciesAdditionalInformationDetail">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_29e2d1fe-78d1-45f3-9299-4d997d53347a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LossContingenciesLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_txg_LesseeOperatingLeaseLeaseNotYetCommencedToBePaidYearOne_08616ec5-0583-4ebe-a32d-1d72c9df8f24" xlink:href="txg-20220630.xsd#txg_LesseeOperatingLeaseLeaseNotYetCommencedToBePaidYearOne"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_29e2d1fe-78d1-45f3-9299-4d997d53347a" xlink:to="loc_txg_LesseeOperatingLeaseLeaseNotYetCommencedToBePaidYearOne_08616ec5-0583-4ebe-a32d-1d72c9df8f24" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLeaseNotYetCommencedTermOfContract1_a506d504-ce0d-4506-9e83-046be3743eb0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLeaseNotYetCommencedTermOfContract1"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_29e2d1fe-78d1-45f3-9299-4d997d53347a" xlink:to="loc_us-gaap_LesseeOperatingLeaseLeaseNotYetCommencedTermOfContract1_a506d504-ce0d-4506-9e83-046be3743eb0" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_2e0e2217-0ae2-4674-9cae-2f77468bbaa8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LossContingenciesTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_29e2d1fe-78d1-45f3-9299-4d997d53347a" xlink:to="loc_us-gaap_LossContingenciesTable_2e0e2217-0ae2-4674-9cae-2f77468bbaa8" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_a472fd5d-d168-4022-bae0-af691e913e8d" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_2e0e2217-0ae2-4674-9cae-2f77468bbaa8" xlink:to="loc_srt_StatementGeographicalAxis_a472fd5d-d168-4022-bae0-af691e913e8d" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_a472fd5d-d168-4022-bae0-af691e913e8d_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_a472fd5d-d168-4022-bae0-af691e913e8d" xlink:to="loc_srt_SegmentGeographicalDomain_a472fd5d-d168-4022-bae0-af691e913e8d_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_dd4cfb4a-9d5d-4e26-afb7-914611d3c47d" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_a472fd5d-d168-4022-bae0-af691e913e8d" xlink:to="loc_srt_SegmentGeographicalDomain_dd4cfb4a-9d5d-4e26-afb7-914611d3c47d" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_txg_PleasantonCaliforniaMember_d93e339d-879a-40d2-8b67-92f7d6630c4b" xlink:href="txg-20220630.xsd#txg_PleasantonCaliforniaMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_dd4cfb4a-9d5d-4e26-afb7-914611d3c47d" xlink:to="loc_txg_PleasantonCaliforniaMember_d93e339d-879a-40d2-8b67-92f7d6630c4b" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermAxis_b3b5d504-f377-4d62-a83d-279f8df3b95f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseContractualTermAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_2e0e2217-0ae2-4674-9cae-2f77468bbaa8" xlink:to="loc_us-gaap_LeaseContractualTermAxis_b3b5d504-f377-4d62-a83d-279f8df3b95f" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermDomain_b3b5d504-f377-4d62-a83d-279f8df3b95f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseContractualTermDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LeaseContractualTermAxis_b3b5d504-f377-4d62-a83d-279f8df3b95f" xlink:to="loc_us-gaap_LeaseContractualTermDomain_b3b5d504-f377-4d62-a83d-279f8df3b95f_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermDomain_9615b67e-890d-4a63-831b-66a4e91aac37" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseContractualTermDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LeaseContractualTermAxis_b3b5d504-f377-4d62-a83d-279f8df3b95f" xlink:to="loc_us-gaap_LeaseContractualTermDomain_9615b67e-890d-4a63-831b-66a4e91aac37" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_txg_A2023Member_a8573aa2-72ae-4177-8ae0-241c4c15a286" xlink:href="txg-20220630.xsd#txg_A2023Member"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LeaseContractualTermDomain_9615b67e-890d-4a63-831b-66a4e91aac37" xlink:to="loc_txg_A2023Member_a8573aa2-72ae-4177-8ae0-241c4c15a286" xlink:type="arc" order="0"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.10xgenomics.com/role/CapitalStockAdditionalInformationDetail" xlink:type="simple" xlink:href="txg-20220630.xsd#CapitalStockAdditionalInformationDetail"/>
<link:definitionLink xlink:role="http://www.10xgenomics.com/role/CapitalStockAdditionalInformationDetail" xlink:type="extended" id="ic372f5b610774f6d855420882c58b929_CapitalStockAdditionalInformationDetail">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_558f1f7e-334a-45b1-81cc-4f20b47c2359" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_6ebd7020-5121-4e27-938d-0686cde87128" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesIssued"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_558f1f7e-334a-45b1-81cc-4f20b47c2359" xlink:to="loc_us-gaap_CommonStockSharesIssued_6ebd7020-5121-4e27-938d-0686cde87128" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_7717cc9e-ba7d-49ef-8620-1cf4ee8b64c5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_558f1f7e-334a-45b1-81cc-4f20b47c2359" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_7717cc9e-ba7d-49ef-8620-1cf4ee8b64c5" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConversionOfStockSharesConverted1_7d320b6a-0ab9-4823-9c68-c68125b84d95" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConversionOfStockSharesConverted1"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_558f1f7e-334a-45b1-81cc-4f20b47c2359" xlink:to="loc_us-gaap_ConversionOfStockSharesConverted1_7d320b6a-0ab9-4823-9c68-c68125b84d95" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_b9ce01e3-dd37-4a9e-8f2f-5d255655d082" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfStockByClassTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_558f1f7e-334a-45b1-81cc-4f20b47c2359" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_b9ce01e3-dd37-4a9e-8f2f-5d255655d082" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_e2d72482-7386-41bb-bec6-4fea19930d9a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_b9ce01e3-dd37-4a9e-8f2f-5d255655d082" xlink:to="loc_us-gaap_StatementClassOfStockAxis_e2d72482-7386-41bb-bec6-4fea19930d9a" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_e2d72482-7386-41bb-bec6-4fea19930d9a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_e2d72482-7386-41bb-bec6-4fea19930d9a" xlink:to="loc_us-gaap_ClassOfStockDomain_e2d72482-7386-41bb-bec6-4fea19930d9a_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_180f928e-8840-486d-89a3-8db017e63e36" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_e2d72482-7386-41bb-bec6-4fea19930d9a" xlink:to="loc_us-gaap_ClassOfStockDomain_180f928e-8840-486d-89a3-8db017e63e36" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_c14d1732-30f4-4d99-a519-ce0e53aa22fd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_180f928e-8840-486d-89a3-8db017e63e36" xlink:to="loc_us-gaap_CommonClassAMember_c14d1732-30f4-4d99-a519-ce0e53aa22fd" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_9c64d863-8ca6-4465-874c-27ef9d8c444a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassBMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_180f928e-8840-486d-89a3-8db017e63e36" xlink:to="loc_us-gaap_CommonClassBMember_9c64d863-8ca6-4465-874c-27ef9d8c444a" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConversionOfStockByUniqueDescriptionAxis_81db58cf-25bd-4513-972a-7fb6e0189b2a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConversionOfStockByUniqueDescriptionAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_b9ce01e3-dd37-4a9e-8f2f-5d255655d082" xlink:to="loc_us-gaap_ConversionOfStockByUniqueDescriptionAxis_81db58cf-25bd-4513-972a-7fb6e0189b2a" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConversionOfStockNameDomain_81db58cf-25bd-4513-972a-7fb6e0189b2a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConversionOfStockNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConversionOfStockByUniqueDescriptionAxis_81db58cf-25bd-4513-972a-7fb6e0189b2a" xlink:to="loc_us-gaap_ConversionOfStockNameDomain_81db58cf-25bd-4513-972a-7fb6e0189b2a_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConversionOfStockNameDomain_0b98a4dc-a60e-4245-b4ae-7d222f6cefad" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConversionOfStockNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConversionOfStockByUniqueDescriptionAxis_81db58cf-25bd-4513-972a-7fb6e0189b2a" xlink:to="loc_us-gaap_ConversionOfStockNameDomain_0b98a4dc-a60e-4245-b4ae-7d222f6cefad" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_txg_SharesConvertedFromClassBToClassAMember_12bace67-4d0d-470f-9292-957fc26da677" xlink:href="txg-20220630.xsd#txg_SharesConvertedFromClassBToClassAMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConversionOfStockNameDomain_0b98a4dc-a60e-4245-b4ae-7d222f6cefad" xlink:to="loc_txg_SharesConvertedFromClassBToClassAMember_12bace67-4d0d-470f-9292-957fc26da677" xlink:type="arc" order="0"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.10xgenomics.com/role/EquityIncentivePlansAdditionalInformationDetail" xlink:type="simple" xlink:href="txg-20220630.xsd#EquityIncentivePlansAdditionalInformationDetail"/>
<link:definitionLink xlink:role="http://www.10xgenomics.com/role/EquityIncentivePlansAdditionalInformationDetail" xlink:type="extended" id="ica3d309548ce4c4095e159c5c39107a5_EquityIncentivePlansAdditionalInformationDetail">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7c3adccc-db26-4655-a74e-3e6571a7d41b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_604c75e3-ded6-4913-9815-832e294f29bb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockCapitalSharesReservedForFutureIssuance"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7c3adccc-db26-4655-a74e-3e6571a7d41b" xlink:to="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_604c75e3-ded6-4913-9815-832e294f29bb" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent_043a5b05-d693-438a-9b62-47e46bce5309" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7c3adccc-db26-4655-a74e-3e6571a7d41b" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent_043a5b05-d693-438a-9b62-47e46bce5309" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_5943fd2e-7bf7-4314-942c-1f971a963c54" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7c3adccc-db26-4655-a74e-3e6571a7d41b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_5943fd2e-7bf7-4314-942c-1f971a963c54" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_668aee11-61cf-4f90-b3d7-9fc9d426bd89" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7c3adccc-db26-4655-a74e-3e6571a7d41b" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_668aee11-61cf-4f90-b3d7-9fc9d426bd89" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_b3694ea3-ec67-46d9-911f-aae157a92352" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_668aee11-61cf-4f90-b3d7-9fc9d426bd89" xlink:to="loc_us-gaap_StatementClassOfStockAxis_b3694ea3-ec67-46d9-911f-aae157a92352" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_b3694ea3-ec67-46d9-911f-aae157a92352_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_b3694ea3-ec67-46d9-911f-aae157a92352" xlink:to="loc_us-gaap_ClassOfStockDomain_b3694ea3-ec67-46d9-911f-aae157a92352_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_0eaaef79-068d-495b-962b-42466802d0e9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_b3694ea3-ec67-46d9-911f-aae157a92352" xlink:to="loc_us-gaap_ClassOfStockDomain_0eaaef79-068d-495b-962b-42466802d0e9" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_8e225f61-2114-40c9-a954-828a79536852" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_0eaaef79-068d-495b-962b-42466802d0e9" xlink:to="loc_us-gaap_CommonClassAMember_8e225f61-2114-40c9-a954-828a79536852" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_a15a8d0c-025e-4d4f-8320-5bdaec74b9a9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_668aee11-61cf-4f90-b3d7-9fc9d426bd89" xlink:to="loc_us-gaap_PlanNameAxis_a15a8d0c-025e-4d4f-8320-5bdaec74b9a9" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_a15a8d0c-025e-4d4f-8320-5bdaec74b9a9_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_a15a8d0c-025e-4d4f-8320-5bdaec74b9a9" xlink:to="loc_us-gaap_PlanNameDomain_a15a8d0c-025e-4d4f-8320-5bdaec74b9a9_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_caa43405-0361-4d3b-abad-b6e6b740fa84" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_a15a8d0c-025e-4d4f-8320-5bdaec74b9a9" xlink:to="loc_us-gaap_PlanNameDomain_caa43405-0361-4d3b-abad-b6e6b740fa84" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_txg_TwoThousandNineteenEmployeeStockPurchasePlanMember_75ef80e7-98cd-4fe1-98d1-251fa54075b7" xlink:href="txg-20220630.xsd#txg_TwoThousandNineteenEmployeeStockPurchasePlanMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_caa43405-0361-4d3b-abad-b6e6b740fa84" xlink:to="loc_txg_TwoThousandNineteenEmployeeStockPurchasePlanMember_75ef80e7-98cd-4fe1-98d1-251fa54075b7" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_37b5c08b-87d7-4578-8f4a-68bbff9029b4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_668aee11-61cf-4f90-b3d7-9fc9d426bd89" xlink:to="loc_us-gaap_AwardTypeAxis_37b5c08b-87d7-4578-8f4a-68bbff9029b4" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_37b5c08b-87d7-4578-8f4a-68bbff9029b4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_37b5c08b-87d7-4578-8f4a-68bbff9029b4" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_37b5c08b-87d7-4578-8f4a-68bbff9029b4_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_148405d9-b659-4e20-a46a-44dd6dbccbdf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_37b5c08b-87d7-4578-8f4a-68bbff9029b4" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_148405d9-b659-4e20-a46a-44dd6dbccbdf" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockMember_73b40428-5d8a-4b03-968d-34de24dfca23" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_148405d9-b659-4e20-a46a-44dd6dbccbdf" xlink:to="loc_us-gaap_EmployeeStockMember_73b40428-5d8a-4b03-968d-34de24dfca23" xlink:type="arc" order="0"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.10xgenomics.com/role/EquityIncentivePlansRecordedStockBasedCompensationExpenseintheCondensedConsolidatedStatementofOperationsDetails" xlink:type="simple" xlink:href="txg-20220630.xsd#EquityIncentivePlansRecordedStockBasedCompensationExpenseintheCondensedConsolidatedStatementofOperationsDetails"/>
<link:definitionLink xlink:role="http://www.10xgenomics.com/role/EquityIncentivePlansRecordedStockBasedCompensationExpenseintheCondensedConsolidatedStatementofOperationsDetails" xlink:type="extended" id="i98cbf071b8ab4c77ab9b813a77bd59dc_EquityIncentivePlansRecordedStockBasedCompensationExpenseintheCondensedConsolidatedStatementofOperationsDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_5107ca4d-b5a0-4f77-8ef6-54d1cc18cae9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_c557a28a-3284-40e2-b586-a4b5a3076854" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_5107ca4d-b5a0-4f77-8ef6-54d1cc18cae9" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_c557a28a-3284-40e2-b586-a4b5a3076854" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_96ab96db-9765-42ec-8362-93479e46fe70" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_5107ca4d-b5a0-4f77-8ef6-54d1cc18cae9" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_96ab96db-9765-42ec-8362-93479e46fe70" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_db29ae7d-a423-47a0-81f1-85a95990ab2c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_96ab96db-9765-42ec-8362-93479e46fe70" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_db29ae7d-a423-47a0-81f1-85a95990ab2c" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_db29ae7d-a423-47a0-81f1-85a95990ab2c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_db29ae7d-a423-47a0-81f1-85a95990ab2c" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_db29ae7d-a423-47a0-81f1-85a95990ab2c_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_06597ba3-030a-4940-b2c8-daeaa23e7c6f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_db29ae7d-a423-47a0-81f1-85a95990ab2c" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_06597ba3-030a-4940-b2c8-daeaa23e7c6f" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfSalesMember_d8dbb637-08d2-414b-a1cc-3a8d8540dabe" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostOfSalesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_06597ba3-030a-4940-b2c8-daeaa23e7c6f" xlink:to="loc_us-gaap_CostOfSalesMember_d8dbb637-08d2-414b-a1cc-3a8d8540dabe" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_c8f49760-569b-4677-8f6c-753a48fc76dc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_06597ba3-030a-4940-b2c8-daeaa23e7c6f" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_c8f49760-569b-4677-8f6c-753a48fc76dc" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_311cd3b2-10af-40ca-90aa-fd8b3266df70" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_06597ba3-030a-4940-b2c8-daeaa23e7c6f" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_311cd3b2-10af-40ca-90aa-fd8b3266df70" xlink:type="arc" order="2"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.10xgenomics.com/role/NetLossPerShareSharesofCommonStockEquivalentsWereExcludedFromTheComputationofDilutedNetLossPerShareDetails" xlink:type="simple" xlink:href="txg-20220630.xsd#NetLossPerShareSharesofCommonStockEquivalentsWereExcludedFromTheComputationofDilutedNetLossPerShareDetails"/>
<link:definitionLink xlink:role="http://www.10xgenomics.com/role/NetLossPerShareSharesofCommonStockEquivalentsWereExcludedFromTheComputationofDilutedNetLossPerShareDetails" xlink:type="extended" id="ie8bd727b72874b2a8161d860c3c2cf2f_NetLossPerShareSharesofCommonStockEquivalentsWereExcludedFromTheComputationofDilutedNetLossPerShareDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_724224de-65e5-4ce0-ac40-157ddf1192c8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_c73619b4-c6d9-4b97-9beb-39c9014c4df2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_724224de-65e5-4ce0-ac40-157ddf1192c8" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_c73619b4-c6d9-4b97-9beb-39c9014c4df2" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_a1bbbe98-1322-48ec-83ef-4b1e9730ac71" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_724224de-65e5-4ce0-ac40-157ddf1192c8" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_a1bbbe98-1322-48ec-83ef-4b1e9730ac71" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_46748821-9524-471a-98ff-fa226b226175" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_a1bbbe98-1322-48ec-83ef-4b1e9730ac71" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_46748821-9524-471a-98ff-fa226b226175" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_46748821-9524-471a-98ff-fa226b226175_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_46748821-9524-471a-98ff-fa226b226175" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_46748821-9524-471a-98ff-fa226b226175_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_5d5c0050-fa15-4c04-b702-3632b394096c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_46748821-9524-471a-98ff-fa226b226175" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_5d5c0050-fa15-4c04-b702-3632b394096c" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_658adf1f-6898-45c7-b990-e6364b90024f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_5d5c0050-fa15-4c04-b702-3632b394096c" xlink:to="loc_us-gaap_EmployeeStockOptionMember_658adf1f-6898-45c7-b990-e6364b90024f" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_8edf29b8-58db-406f-9f8f-2ad0f9e0a2e9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_5d5c0050-fa15-4c04-b702-3632b394096c" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_8edf29b8-58db-406f-9f8f-2ad0f9e0a2e9" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_txg_SharesUnderEsppPlanMember_1c51c77c-6a25-4a9c-a9e1-2bc5de1b653e" xlink:href="txg-20220630.xsd#txg_SharesUnderEsppPlanMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_5d5c0050-fa15-4c04-b702-3632b394096c" xlink:to="loc_txg_SharesUnderEsppPlanMember_1c51c77c-6a25-4a9c-a9e1-2bc5de1b653e" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_txg_SharesSubjectToRepurchaseMember_8c0b739c-e0cf-4e00-8838-c30d5d38227e" xlink:href="txg-20220630.xsd#txg_SharesSubjectToRepurchaseMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_5d5c0050-fa15-4c04-b702-3632b394096c" xlink:to="loc_txg_SharesSubjectToRepurchaseMember_8c0b739c-e0cf-4e00-8838-c30d5d38227e" xlink:type="arc" order="3"/>
<link:loc xlink:type="locator" xlink:label="loc_txg_ContingentRestrictedSharesMember_833b2025-3585-46a2-9c1d-46690ef5f833" xlink:href="txg-20220630.xsd#txg_ContingentRestrictedSharesMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_5d5c0050-fa15-4c04-b702-3632b394096c" xlink:to="loc_txg_ContingentRestrictedSharesMember_833b2025-3585-46a2-9c1d-46690ef5f833" xlink:type="arc" order="4"/>
</link:definitionLink>
<link:roleRef roleURI="http://www.10xgenomics.com/role/SubsequentEventsDetails" xlink:type="simple" xlink:href="txg-20220630.xsd#SubsequentEventsDetails"/>
<link:definitionLink xlink:role="http://www.10xgenomics.com/role/SubsequentEventsDetails" xlink:type="extended" id="i9ec0732757d148c19b1182b49a340703_SubsequentEventsDetails">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventLineItems_885649a3-f234-43c2-bed6-a67ab44a5375" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventLineItems"/>
<link:loc xlink:type="locator" xlink:label="loc_txg_ReductionInForceExpectedTerminationOfPercentage_5b3bca04-3378-42e2-93bf-5c98f4d44744" xlink:href="txg-20220630.xsd#txg_ReductionInForceExpectedTerminationOfPercentage"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_885649a3-f234-43c2-bed6-a67ab44a5375" xlink:to="loc_txg_ReductionInForceExpectedTerminationOfPercentage_5b3bca04-3378-42e2-93bf-5c98f4d44744" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeveranceCosts1_08b0bce0-35f3-40c3-b313-0ed481568d3c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeveranceCosts1"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_885649a3-f234-43c2-bed6-a67ab44a5375" xlink:to="loc_us-gaap_SeveranceCosts1_08b0bce0-35f3-40c3-b313-0ed481568d3c" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTable_e8e4becb-66f3-4090-b08c-07b282ea5900" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTable"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SubsequentEventLineItems_885649a3-f234-43c2-bed6-a67ab44a5375" xlink:to="loc_us-gaap_SubsequentEventTable_e8e4becb-66f3-4090-b08c-07b282ea5900" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_9ac673b2-ce8a-4d58-9a7d-99c14e5450f0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_e8e4becb-66f3-4090-b08c-07b282ea5900" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_9ac673b2-ce8a-4d58-9a7d-99c14e5450f0" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_9ac673b2-ce8a-4d58-9a7d-99c14e5450f0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_9ac673b2-ce8a-4d58-9a7d-99c14e5450f0" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_9ac673b2-ce8a-4d58-9a7d-99c14e5450f0_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_744e0b70-e9e1-4ce2-a78d-e03711fa3e61" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_9ac673b2-ce8a-4d58-9a7d-99c14e5450f0" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_744e0b70-e9e1-4ce2-a78d-e03711fa3e61" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_38ddbca0-ff0d-4bfd-80e2-57a3ec439a83" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_744e0b70-e9e1-4ce2-a78d-e03711fa3e61" xlink:to="loc_us-gaap_SubsequentEventMember_38ddbca0-ff0d-4bfd-80e2-57a3ec439a83" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_8ef04c15-5769-4d18-907d-59447dd49dc8" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_e8e4becb-66f3-4090-b08c-07b282ea5900" xlink:to="loc_srt_RangeAxis_8ef04c15-5769-4d18-907d-59447dd49dc8" xlink:type="arc" order="2"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_8ef04c15-5769-4d18-907d-59447dd49dc8_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_8ef04c15-5769-4d18-907d-59447dd49dc8" xlink:to="loc_srt_RangeMember_8ef04c15-5769-4d18-907d-59447dd49dc8_default" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_67c9bb85-7eea-4db0-a6d6-9eaa0f4d083b" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_8ef04c15-5769-4d18-907d-59447dd49dc8" xlink:to="loc_srt_RangeMember_67c9bb85-7eea-4db0-a6d6-9eaa0f4d083b" xlink:type="arc" order="1"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_5fcc47cb-28c3-49eb-8e1f-ad1e68d21569" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_67c9bb85-7eea-4db0-a6d6-9eaa0f4d083b" xlink:to="loc_srt_MinimumMember_5fcc47cb-28c3-49eb-8e1f-ad1e68d21569" xlink:type="arc" order="0"/>
<link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_f83266d7-a856-4a43-ac2c-866d2f4c83ea" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
<link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_67c9bb85-7eea-4db0-a6d6-9eaa0f4d083b" xlink:to="loc_srt_MaximumMember_f83266d7-a856-4a43-ac2c-866d2f4c83ea" xlink:type="arc" order="1"/>
</link:definitionLink>
</link:linkbase>


2 Subsequent Filings that Reference this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 2/15/24  10x Genomics, Inc.                10-K       12/31/23   95:15M
 2/16/23  10x Genomics, Inc.                10-K       12/31/22   93:23M


3 Previous Filings that this Filing References

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 3/26/20  10x Genomics, Inc.                8-K:5,9     3/26/20    2:130K                                   Donnelley … Solutions/FA
 9/16/19  10x Genomics, Inc.                8-K:3,5,7,8 9/13/19    4:207K                                   Donnelley … Solutions/FA
 8/19/19  10x Genomics, Inc.                S-1                   24:13M                                    Donnelley … Solutions/FA
Top
Filing Submission 0001770787-22-000049   –   Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)

Copyright © 2024 Fran Finnegan & Company LLC – All Rights Reserved.
AboutPrivacyRedactionsHelp — Sun., Apr. 28, 5:29:17.2pm ET