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| <link:usedOn> link:calculationLink </link:usedOn> |
| <link:usedOn> link:definitionLink </link:usedOn> |
| </link:roleType> |
| | | <link:roleType roleURI="http://oragenics.com/role/ScheduleOfSupplementalBalanceSheetInformationRelatedToLeasesDetails" id="ScheduleOfSupplementalBalanceSheetInformationRelatedToLeasesDetails"> |
| <link:definition> 995559 - Disclosure - Schedule of Supplemental Balance Sheet Information Related to Leases (Details) </link:definition> |
| <link:usedOn> link:presentationLink </link:usedOn> |
| <link:usedOn> link:calculationLink </link:usedOn> |
| <link:usedOn> link:definitionLink </link:usedOn> |
| </link:roleType> |
| | | <link:roleType roleURI="http://oragenics.com/role/ScheduleOfOperatingLeaseLiabilitiesDetails" id="ScheduleOfOperatingLeaseLiabilitiesDetails"> |
| <link:definition> 995560 - Disclosure - Schedule of Operating lease liabilities (Details) </link:definition> |
| <link:usedOn> link:presentationLink </link:usedOn> |
| <link:usedOn> link:calculationLink </link:usedOn> |
| <link:usedOn> link:definitionLink </link:usedOn> |
| </link:roleType> |
| | | <link:roleType roleURI="http://oragenics.com/role/ScheduleOfCostComponentOfOperatingLeasesDetails" id="ScheduleOfCostComponentOfOperatingLeasesDetails"> |
| <link:definition> 995561 - Disclosure - Schedule of Cost Component of Operating Leases (Details) </link:definition> |
| <link:usedOn> link:presentationLink </link:usedOn> |
| <link:usedOn> link:calculationLink </link:usedOn> |
| <link:usedOn> link:definitionLink </link:usedOn> |
| </link:roleType> |
| | | <link:roleType roleURI="http://oragenics.com/role/ScheduleOfSupplementalCashFlowInformationRelatedToOperatingLeasesDetails" id="ScheduleOfSupplementalCashFlowInformationRelatedToOperatingLeasesDetails"> |
| <link:definition> 995562 - Disclosure - Schedule of Supplemental Cash Flow Information Related to Operating Leases (Details) </link:definition> |
| <link:usedOn> link:presentationLink </link:usedOn> |
| <link:usedOn> link:calculationLink </link:usedOn> |
| <link:usedOn> link:definitionLink </link:usedOn> |
| </link:roleType> |
| | | <link:roleType roleURI="http://oragenics.com/role/CommitmentsAndContingenciesDetailsNarrative" id="CommitmentsAndContingenciesDetailsNarrative"> |
| <link:definition> 995563 - Disclosure - Commitments and Contingencies (Details Narrative) </link:definition> |
| <link:usedOn> link:presentationLink </link:usedOn> |
| <link:usedOn> link:calculationLink </link:usedOn> |
| <link:usedOn> link:definitionLink </link:usedOn> |
| </link:roleType> |
| | | <link:roleType roleURI="http://oragenics.com/role/SubsequentEventsDetailsNarrative" id="SubsequentEventsDetailsNarrative"> |
| <link:definition> 995564 - Disclosure - Subsequent Events (Details Narrative) </link:definition> |
| <link:usedOn> link:presentationLink </link:usedOn> |
| <link:usedOn> link:calculationLink </link:usedOn> |
| <link:usedOn> link:definitionLink </link:usedOn> |
| </link:roleType> |
| | | <link:linkbaseRef xlink:type="simple" xlink:href="ogen-20231231_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:title="Presentation Links"/> |
| | | <link:linkbaseRef xlink:type="simple" xlink:href="ogen-20231231_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:title="Label Links"/> |
| | | <link:linkbaseRef xlink:type="simple" xlink:href="ogen-20231231_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:title="Calculation Links"/> |
| | | <link:linkbaseRef xlink:type="simple" xlink:href="ogen-20231231_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:title="Definition Links"/> |
| | | </appinfo> |
| | </annotation> |
| <import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/> |
| <import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/> |
| <import namespace="http://xbrl.sec.gov/dei/2023" schemaLocation="https://xbrl.sec.gov/dei/2023/dei-2023.xsd"/> |
| <import namespace="http://fasb.org/us-gaap/2023" schemaLocation="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd"/> |
| <import namespace="http://fasb.org/us-types/2023" schemaLocation="https://xbrl.fasb.org/us-gaap/2023/elts/us-types-2023.xsd"/> |
| <import namespace="http://www.xbrl.org/dtr/type/2022-03-31" schemaLocation="https://www.xbrl.org/dtr/type/2022-03-31/types.xsd"/> |
| <import namespace="http://xbrl.sec.gov/ecd/2023" schemaLocation="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd"/> |
| <import namespace="http://xbrl.sec.gov/country/2023" schemaLocation="https://xbrl.sec.gov/country/2023/country-2023.xsd"/> |
| <import namespace="http://fasb.org/srt/2023" schemaLocation="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd"/> |
| <import namespace="http://fasb.org/srt-types/2023" schemaLocation="https://xbrl.fasb.org/srt/2023/elts/srt-types-2023.xsd"/> |
| <element id="OGEN_OdysseyHealthIncMember" name="OdysseyHealthIncMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_LaboratoryEquipmentMember" name="LaboratoryEquipmentMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_OfficeandComputerEquipmentMember" name="OfficeandComputerEquipmentMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_DirectorsAndOfficersLiabilityMember" name="DirectorsAndOfficersLiabilityMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_OfficersMember" name="OfficersMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_SecuritiesPurchaseAgreementMember" name="SecuritiesPurchaseAgreementMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_AssetPurchaseAgreementMember" name="AssetPurchaseAgreementMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_RangeOneMember" name="RangeOneMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_RangeTwoMember" name="RangeTwoMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_RangeThreeMember" name="RangeThreeMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_RangeFourMember" name="RangeFourMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_RangeFiveMember" name="RangeFiveMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_RangeSixMember" name="RangeSixMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_TwoThousandTwentyOneEquityIncentivePlanMember" name="TwoThousandTwentyOneEquityIncentivePlanMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_ResearchandDevelopmentMember" name="ResearchandDevelopmentMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_AlachuaFacilityMember" name="AlachuaFacilityMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_TampaFacilityMember" name="TampaFacilityMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_PrepaidResearchAndDevelopmentExpense" name="PrepaidResearchAndDevelopmentExpense" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_StockIssuedDuringPeriodValueConversionOfSeriesFPreferredStockToCommonStock" name="StockIssuedDuringPeriodValueConversionOfSeriesFPreferredStockToCommonStock" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_StockIssuedDuringPeriodSharesConversionOfSeriesFPreferredStockToCommonStock" name="StockIssuedDuringPeriodSharesConversionOfSeriesFPreferredStockToCommonStock" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_StockIssuedDuringPeriodValueConversionOfSeriesBPreferredStockToCommonStock" name="StockIssuedDuringPeriodValueConversionOfSeriesBPreferredStockToCommonStock" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_StockIssuedDuringPeriodSharesConversionOfSeriesBPreferredStockToCommonStock" name="StockIssuedDuringPeriodSharesConversionOfSeriesBPreferredStockToCommonStock" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_StockIssuedDuringPeriodValueProceedsFromIssuanceForCommonStock" name="StockIssuedDuringPeriodValueProceedsFromIssuanceForCommonStock" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_StockIssuedDuringPeriodSharesProceedsFromIssuanceForCommonStock" name="StockIssuedDuringPeriodSharesProceedsFromIssuanceForCommonStock" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_WriteOffOfInProcessResearchAndDevelopment" name="WriteOffOfInProcessResearchAndDevelopment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_IncreaseDecreaseInOperatingLeaseRightOfUseAssets" name="IncreaseDecreaseInOperatingLeaseRightOfUseAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_IncreaseDecreaseInPrepaidResearchAndDevelopment" name="IncreaseDecreaseInPrepaidResearchAndDevelopment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_IssuanceOfSeriesFPreferredStockForInprocessResearchAndDevelopment" name="IssuanceOfSeriesFPreferredStockForInprocessResearchAndDevelopment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_ConversionOfStockAmountConverted" name="ConversionOfStockAmountConverted" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_ConversionOfStockAmountIssued" name="ConversionOfStockAmountIssued" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_DisclosurePrepaidExpenseAssetsCurrentAndLongtermAbstract" name="DisclosurePrepaidExpenseAssetsCurrentAndLongtermAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_PrepaidExpenseAssetsDisclosureTextBlock" name="PrepaidExpenseAssetsDisclosureTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_ScheduleOfPrepaidExpenseAndOtherCurrentAssetsTableTextBlock" name="ScheduleOfPrepaidExpenseAndOtherCurrentAssetsTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_ScheduleOfSupplementalBalanceSheetInformationRelatedToLeasesTableTextBlock" name="ScheduleOfSupplementalBalanceSheetInformationRelatedToLeasesTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_ScheduleOfSupplementalCashFlowInformationRelatedToOperatingLeasesTableTextBlock" name="ScheduleOfSupplementalCashFlowInformationRelatedToOperatingLeasesTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_NetProceedsFromIssuanceOrSaleOfEquity" name="NetProceedsFromIssuanceOrSaleOfEquity" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_CurrentAndLongTermPrepaidAssets" name="CurrentAndLongTermPrepaidAssets" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_ClassOfWarrantOrRightOutstandingExercisable" name="ClassOfWarrantOrRightOutstandingExercisable" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisable" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisable" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedInPeriodFairValue" name="SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedInPeriodFairValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_PrepaidExpenseAndOtherCurrentAssetsDisclosureTextBlock" name="PrepaidExpenseAndOtherCurrentAssetsDisclosureTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_SecurityPurchaseAgreementMember" name="SecurityPurchaseAgreementMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_CommonStocksSharesOutstanding" name="CommonStocksSharesOutstanding" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_RangeSevenMember" name="RangeSevenMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_UnrecognizedTaxBenefitsIncreasesForReturnToProvisionTrueUp" name="UnrecognizedTaxBenefitsIncreasesForReturnToProvisionTrueUp" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_GainLossOnDisposalOfFixedAssets" name="GainLossOnDisposalOfFixedAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_UnderwritingAgreementMember" name="UnderwritingAgreementMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_BusinessCombinationConsiderationTransferred" name="BusinessCombinationConsiderationTransferred" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item"/> |
| <element id="OGEN_ThirdPartyVendorMember" name="ThirdPartyVendorMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item"/> |
| </schema> |