SEC Info  
    Home      Search      My Interests      Help      Sign In      Please Sign In

Oragenics Inc. – ‘10-K’ for 12/31/23 – ‘EX-101.CAL’

On:  Friday, 3/29/24, at 4:16pm ET   ·   For:  12/31/23   ·   Accession #:  1493152-24-11979   ·   File #:  1-32188

Previous ‘10-K’:  ‘10-K’ on 4/17/23 for 12/31/22   ·   Latest ‘10-K’:  This Filing   ·   31 References:   

Find Words in Filings emoji
 
  in    Show  and   Hints

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 3/29/24  Oragenics Inc.                    10-K       12/31/23   80:6.5M                                   M2 Compliance LLC/FA

Annual Report   —   Form 10-K   —   SEA’34

Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-K        Annual Report                                       HTML   2.33M 
 2: EX-4.8      Instrument Defining the Rights of Security Holders  HTML     72K 
 3: EX-23.1     Consent of Expert or Counsel                        HTML     22K 
 4: EX-23.2     Consent of Expert or Counsel                        HTML     21K 
 9: EX-97.1     Clawback Policy re: Recovery of Erroneously         HTML     37K 
                Awarded Compensation                                             
 5: EX-31.1     Certification -- §302 - SOA'02                      HTML     26K 
 6: EX-31.2     Certification -- §302 - SOA'02                      HTML     26K 
 7: EX-32.1     Certification -- §906 - SOA'02                      HTML     23K 
 8: EX-32.2     Certification -- §906 - SOA'02                      HTML     23K 
15: R1          Cover                                               HTML    103K 
16: R2          Consolidated Balance Sheets                         HTML    101K 
17: R3          Consolidated Balance Sheets (Parenthetical)         HTML     45K 
18: R4          Consolidated Statements of Operations               HTML     89K 
19: R5          Consolidated Statements of Changes in               HTML     82K 
                Shareholders' Equity                                             
20: R6          Consolidated Statements of Cash Flows               HTML    105K 
21: R7          Pay vs Performance Disclosure                       HTML     34K 
22: R8          Insider Trading Arrangements                        HTML     28K 
23: R9          Basis of Presentation                               HTML     36K 
24: R10         Significant Accounting Policies                     HTML     51K 
25: R11         Acquisition of Concussion Assets                    HTML     32K 
26: R12         Property and Equipment, net                         HTML     34K 
27: R13         Accounts Payable and Accrued Expenses               HTML     29K 
28: R14         Short-Term Notes Payable                            HTML     32K 
29: R15         Prepaid Expense Assets - Current and Long-Term      HTML     30K 
30: R16         Shareholders? Equity                                HTML     65K 
31: R17         Stock Compensation Plan                             HTML     77K 
32: R18         Retirement Plan                                     HTML     29K 
33: R19         Income Taxes                                        HTML     72K 
34: R20         Commitments and Contingencies                       HTML     49K 
35: R21         Subsequent Events                                   HTML     30K 
36: R22         Significant Accounting Policies (Policies)          HTML     91K 
37: R23         Acquisition of Concussion Assets (Tables)           HTML     27K 
38: R24         Property and Equipment, net (Tables)                HTML     31K 
39: R25         Accounts Payable and Accrued Expenses (Tables)      HTML     28K 
40: R26         Short-Term Notes Payable (Tables)                   HTML     31K 
41: R27         Prepaid Expense Assets - Current and Long-Term      HTML     28K 
                (Tables)                                                         
42: R28         Shareholders? Equity (Tables)                       HTML     40K 
43: R29         Stock Compensation Plan (Tables)                    HTML     69K 
44: R30         Income Taxes (Tables)                               HTML     65K 
45: R31         Commitments and Contingencies (Tables)              HTML     45K 
46: R32         Basis of Presentation (Details Narrative)           HTML     48K 
47: R33         Significant Accounting Policies (Details            HTML     31K 
                Narrative)                                                       
48: R34         Schedule of Acquisition of Assets (Details)         HTML     35K 
49: R35         Acquisition of Concussion Assets (Details           HTML     35K 
                Narrative)                                                       
50: R36         Summary of Property and Equipment, Net (Details)    HTML     39K 
51: R37         Property and Equipment, net (Details Narrative)     HTML     28K 
52: R38         Summary of Accounts Payable and Accrued Expenses    HTML     33K 
                (Details)                                                        
53: R39         Summary of Short-Term Notes payable (Details)       HTML     24K 
54: R40         Summary of Short-Term Notes payable (Details)       HTML     32K 
                (Parenthetical)                                                  
55: R41         Schedule of Expense and Other Current Assets        HTML     34K 
                (Details)                                                        
56: R42         Schedule of Warrants Outstanding and Exercisable    HTML     46K 
                (Details)                                                        
57: R43         Shareholders? Equity (Details Narrative)            HTML     72K 
58: R44         Summary of Assumptions Used to Estimate the Fair    HTML     40K 
                Value of Stock Options Granted (Details)                         
59: R45         Summary of Stock Option Activity (Details)          HTML     58K 
60: R46         Summary of Weighted Average Grant Fair Value of     HTML     28K 
                Stock Options (Details)                                          
61: R47         Schedule of Restricted Stock Activity (Details)     HTML     42K 
62: R48         Stock Compensation Plan (Details Narrative)         HTML     49K 
63: R49         Retirement Plan (Details Narrative)                 HTML     25K 
64: R50         Schedule of Components of Provision for Income      HTML     34K 
                Taxes (Details)                                                  
65: R51         Summary of Components of Deferred Tax (Details)     HTML     39K 
66: R52         Schedule of Reconciliation of Tax Computed at       HTML     39K 
                Statutory Federal Rate (Details)                                 
67: R53         Schedule of Reconciliation of Tax Computed at       HTML     24K 
                Statutory Federal Rate (Details) (Parenthetical)                 
68: R54         Schedule of Reconciliation of Unrecognized Tax      HTML     31K 
                Benefits (Details)                                               
69: R55         Income Taxes (Details Narrative)                    HTML     37K 
70: R56         Schedule of Supplemental Balance Sheet Information  HTML     26K 
                Related to Leases (Details)                                      
71: R57         Schedule of Operating lease liabilities (Details)   HTML     29K 
72: R58         Schedule of Cost Component of Operating Leases      HTML     28K 
                (Details)                                                        
73: R59         Schedule of Supplemental Cash Flow Information      HTML     24K 
                Related to Operating Leases (Details)                            
74: R60         Commitments and Contingencies (Details Narrative)   HTML     51K 
75: R61         Subsequent Events (Details Narrative)               HTML     31K 
77: XML         IDEA XML File -- Filing Summary                      XML    135K 
80: XML         XBRL Instance -- form10-k_htm                        XML    839K 
76: EXCEL       IDEA Workbook of Financial Report Info              XLSX    111K 
11: EX-101.CAL  XBRL Calculations -- ogen-20231231_cal               XML    163K 
12: EX-101.DEF  XBRL Definitions -- ogen-20231231_def                XML    329K 
13: EX-101.LAB  XBRL Labels -- ogen-20231231_lab                     XML    942K 
14: EX-101.PRE  XBRL Presentations -- ogen-20231231_pre              XML    722K 
10: EX-101.SCH  XBRL Schema -- ogen-20231231                         XSD    124K 
78: JSON        XBRL Instance as JSON Data -- MetaLinks              404±   569K 
79: ZIP         XBRL Zipped Folder -- 0001493152-24-011979-xbrl      Zip    459K 


‘EX-101.CAL’   —   XBRL Calculations — ogen-20231231_cal


This Exhibit is an XBRL File.


                                                                                                                                                                                
<?xml version="1.0" standalone="no" encoding="windows-1252"?>
<!-- Field: Doc-Info; Name: Generator; Value: GoFiler Complete; Version: 5.22a -->
<!-- Field: Doc-Info; Name: VendorURI; Value: https://www.novaworks.com -->
<!-- Field: Doc-Info; Name: Status; Value: 0x00000000 -->
<link:linkbase xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xbrli="http://www.xbrl.org/2003/instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
<link:roleRef roleURI="http://oragenics.com/role/Cover" xlink:href="ogen-20231231.xsd#Cover" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/BalanceSheets" xlink:href="ogen-20231231.xsd#BalanceSheets" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/BalanceSheetsParenthetical" xlink:href="ogen-20231231.xsd#BalanceSheetsParenthetical" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/StatementsOfOperations" xlink:href="ogen-20231231.xsd#StatementsOfOperations" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/StatementsOfChangesInShareholdersEquity" xlink:href="ogen-20231231.xsd#StatementsOfChangesInShareholdersEquity" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/StatementsOfCashFlows" xlink:href="ogen-20231231.xsd#StatementsOfCashFlows" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/BasisOfPresentation" xlink:href="ogen-20231231.xsd#BasisOfPresentation" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/SignificantAccountingPolicies" xlink:href="ogen-20231231.xsd#SignificantAccountingPolicies" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/AcquisitionOfConcussionAssets" xlink:href="ogen-20231231.xsd#AcquisitionOfConcussionAssets" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/PropertyAndEquipmentNet" xlink:href="ogen-20231231.xsd#PropertyAndEquipmentNet" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/AccountsPayableAndAccruedExpenses" xlink:href="ogen-20231231.xsd#AccountsPayableAndAccruedExpenses" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/Short-termNotesPayable" xlink:href="ogen-20231231.xsd#Short-termNotesPayable" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/PrepaidExpenseAssetsCurrentAndLong-term" xlink:href="ogen-20231231.xsd#PrepaidExpenseAssetsCurrentAndLong-term" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/ShareholdersEquity" xlink:href="ogen-20231231.xsd#ShareholdersEquity" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/StockCompensationPlan" xlink:href="ogen-20231231.xsd#StockCompensationPlan" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/RetirementPlan" xlink:href="ogen-20231231.xsd#RetirementPlan" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/IncomeTaxes" xlink:href="ogen-20231231.xsd#IncomeTaxes" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/CommitmentsAndContingencies" xlink:href="ogen-20231231.xsd#CommitmentsAndContingencies" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/SubsequentEvents" xlink:href="ogen-20231231.xsd#SubsequentEvents" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/SignificantAccountingPoliciesPolicies" xlink:href="ogen-20231231.xsd#SignificantAccountingPoliciesPolicies" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/AcquisitionOfConcussionAssetsTables" xlink:href="ogen-20231231.xsd#AcquisitionOfConcussionAssetsTables" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/PropertyAndEquipmentNetTables" xlink:href="ogen-20231231.xsd#PropertyAndEquipmentNetTables" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/AccountsPayableAndAccruedExpensesTables" xlink:href="ogen-20231231.xsd#AccountsPayableAndAccruedExpensesTables" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/Short-termNotesPayableTables" xlink:href="ogen-20231231.xsd#Short-termNotesPayableTables" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/PrepaidExpenseAssetsCurrentAndLong-termTables" xlink:href="ogen-20231231.xsd#PrepaidExpenseAssetsCurrentAndLong-termTables" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/ShareholdersEquityTables" xlink:href="ogen-20231231.xsd#ShareholdersEquityTables" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/StockCompensationPlanTables" xlink:href="ogen-20231231.xsd#StockCompensationPlanTables" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/IncomeTaxesTables" xlink:href="ogen-20231231.xsd#IncomeTaxesTables" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/CommitmentsAndContingenciesTables" xlink:href="ogen-20231231.xsd#CommitmentsAndContingenciesTables" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/BasisOfPresentationDetailsNarrative" xlink:href="ogen-20231231.xsd#BasisOfPresentationDetailsNarrative" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/SignificantAccountingPoliciesDetailsNarrative" xlink:href="ogen-20231231.xsd#SignificantAccountingPoliciesDetailsNarrative" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/ScheduleOfAcquisitionOfAssetsDetails" xlink:href="ogen-20231231.xsd#ScheduleOfAcquisitionOfAssetsDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/AcquisitionOfConcussionAssetsDetailsNarrative" xlink:href="ogen-20231231.xsd#AcquisitionOfConcussionAssetsDetailsNarrative" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/SummaryOfPropertyAndEquipmentNetDetails" xlink:href="ogen-20231231.xsd#SummaryOfPropertyAndEquipmentNetDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/PropertyAndEquipmentNetDetailsNarrative" xlink:href="ogen-20231231.xsd#PropertyAndEquipmentNetDetailsNarrative" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/SummaryOfAccountsPayableAndAccruedExpensesDetails" xlink:href="ogen-20231231.xsd#SummaryOfAccountsPayableAndAccruedExpensesDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/SummaryOfShort-termNotesPayableDetails" xlink:href="ogen-20231231.xsd#SummaryOfShort-termNotesPayableDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/SummaryOfShort-termNotesPayableDetailsParenthetical" xlink:href="ogen-20231231.xsd#SummaryOfShort-termNotesPayableDetailsParenthetical" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/ScheduleOfExpenseAndOtherCurrentAssetsDetails" xlink:href="ogen-20231231.xsd#ScheduleOfExpenseAndOtherCurrentAssetsDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/ScheduleOfWarrantsOutstandingAndExercisableDetails" xlink:href="ogen-20231231.xsd#ScheduleOfWarrantsOutstandingAndExercisableDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/ShareholdersEquityDetailsNarrative" xlink:href="ogen-20231231.xsd#ShareholdersEquityDetailsNarrative" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/SummaryOfAssumptionsUsedToEstimateFairValueOfStockOptionsGrantedDetails" xlink:href="ogen-20231231.xsd#SummaryOfAssumptionsUsedToEstimateFairValueOfStockOptionsGrantedDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/SummaryOfStockOptionActivityDetails" xlink:href="ogen-20231231.xsd#SummaryOfStockOptionActivityDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/SummaryOfWeightedAverageGrantFairValueOfStockOptionsDetails" xlink:href="ogen-20231231.xsd#SummaryOfWeightedAverageGrantFairValueOfStockOptionsDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/ScheduleOfRestrictedStockActivityDetails" xlink:href="ogen-20231231.xsd#ScheduleOfRestrictedStockActivityDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/StockCompensationPlanDetailsNarrative" xlink:href="ogen-20231231.xsd#StockCompensationPlanDetailsNarrative" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/RetirementPlanDetailsNarrative" xlink:href="ogen-20231231.xsd#RetirementPlanDetailsNarrative" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/ScheduleOfComponentsOfProvisionForIncomeTaxesDetails" xlink:href="ogen-20231231.xsd#ScheduleOfComponentsOfProvisionForIncomeTaxesDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/SummaryOfComponentsOfDeferredTaxDetails" xlink:href="ogen-20231231.xsd#SummaryOfComponentsOfDeferredTaxDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/ScheduleOfReconciliationOfTaxComputedAtStatutoryFederalRateDetails" xlink:href="ogen-20231231.xsd#ScheduleOfReconciliationOfTaxComputedAtStatutoryFederalRateDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/ScheduleOfReconciliationOfTaxComputedAtStatutoryFederalRateDetailsParenthetical" xlink:href="ogen-20231231.xsd#ScheduleOfReconciliationOfTaxComputedAtStatutoryFederalRateDetailsParenthetical" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/ScheduleOfReconciliationOfUnrecognizedTaxBenefitsDetails" xlink:href="ogen-20231231.xsd#ScheduleOfReconciliationOfUnrecognizedTaxBenefitsDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/IncomeTaxesDetailsNarrative" xlink:href="ogen-20231231.xsd#IncomeTaxesDetailsNarrative" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/ScheduleOfSupplementalBalanceSheetInformationRelatedToLeasesDetails" xlink:href="ogen-20231231.xsd#ScheduleOfSupplementalBalanceSheetInformationRelatedToLeasesDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/ScheduleOfOperatingLeaseLiabilitiesDetails" xlink:href="ogen-20231231.xsd#ScheduleOfOperatingLeaseLiabilitiesDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/ScheduleOfCostComponentOfOperatingLeasesDetails" xlink:href="ogen-20231231.xsd#ScheduleOfCostComponentOfOperatingLeasesDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/ScheduleOfSupplementalCashFlowInformationRelatedToOperatingLeasesDetails" xlink:href="ogen-20231231.xsd#ScheduleOfSupplementalCashFlowInformationRelatedToOperatingLeasesDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/CommitmentsAndContingenciesDetailsNarrative" xlink:href="ogen-20231231.xsd#CommitmentsAndContingenciesDetailsNarrative" xlink:type="simple"/>
<link:roleRef roleURI="http://oragenics.com/role/SubsequentEventsDetailsNarrative" xlink:href="ogen-20231231.xsd#SubsequentEventsDetailsNarrative" xlink:type="simple"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/Cover" xlink:title="00000001 - Document - Cover"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/BalanceSheets" xlink:title="00000002 - Statement - Consolidated Balance Sheets">
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsCurrent" xlink:label="loc_us-gaapAssetsCurrent"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaapCashAndCashEquivalentsAtCarryingValue"/>
<link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssetsCurrent" xlink:to="loc_us-gaapCashAndCashEquivalentsAtCarryingValue" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:label="loc_us-gaapPrepaidExpenseAndOtherAssetsCurrent"/>
<link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssetsCurrent" xlink:to="loc_us-gaapPrepaidExpenseAndOtherAssetsCurrent" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Assets" xlink:label="loc_us-gaapAssets"/>
<link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapAssetsCurrent" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaapPropertyPlantAndEquipmentNet"/>
<link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapPropertyPlantAndEquipmentNet" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="ogen-20231231.xsd#OGEN_PrepaidResearchAndDevelopmentExpense" xlink:label="loc_OGENPrepaidResearchAndDevelopmentExpense"/>
<link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_OGENPrepaidResearchAndDevelopmentExpense" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseRightOfUseAsset" xlink:label="loc_us-gaapOperatingLeaseRightOfUseAsset"/>
<link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapOperatingLeaseRightOfUseAsset" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_us-gaapLiabilitiesCurrent"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent" xlink:label="loc_us-gaapAccountsPayableAndAccruedLiabilitiesCurrent"/>
<link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_us-gaapAccountsPayableAndAccruedLiabilitiesCurrent" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NotesPayableCurrent" xlink:label="loc_us-gaapNotesPayableCurrent"/>
<link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_us-gaapNotesPayableCurrent" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseLiabilityCurrent" xlink:label="loc_us-gaapOperatingLeaseLiabilityCurrent"/>
<link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_us-gaapOperatingLeaseLiabilityCurrent" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesNoncurrent" xlink:label="loc_us-gaapLiabilitiesNoncurrent"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent" xlink:label="loc_us-gaapOperatingLeaseLiabilityNoncurrent"/>
<link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesNoncurrent" xlink:to="loc_us-gaapOperatingLeaseLiabilityNoncurrent" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaapStockholdersEquity"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PreferredStockValue" xlink:label="loc_us-gaapPreferredStockValue"/>
<link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquity" xlink:to="loc_us-gaapPreferredStockValue" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockValue" xlink:label="loc_us-gaapCommonStockValue"/>
<link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquity" xlink:to="loc_us-gaapCommonStockValue" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="loc_us-gaapAdditionalPaidInCapital"/>
<link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquity" xlink:to="loc_us-gaapAdditionalPaidInCapital" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaapRetainedEarningsAccumulatedDeficit"/>
<link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquity" xlink:to="loc_us-gaapRetainedEarningsAccumulatedDeficit" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaapLiabilitiesAndStockholdersEquity"/>
<link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesAndStockholdersEquity" xlink:to="loc_us-gaapLiabilitiesCurrent" xlink:type="arc" weight="1"/>
<link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesAndStockholdersEquity" xlink:to="loc_us-gaapLiabilitiesNoncurrent" xlink:type="arc" weight="1"/>
<link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesAndStockholdersEquity" xlink:to="loc_us-gaapStockholdersEquity" xlink:type="arc" weight="1"/>
</link:calculationLink>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/BalanceSheetsParenthetical" xlink:title="00000003 - Statement - Consolidated Balance Sheets (Parenthetical)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/StatementsOfOperations" xlink:title="00000004 - Statement - Consolidated Statements of Operations">
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingExpenses" xlink:label="loc_us-gaapOperatingExpenses"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="loc_us-gaapResearchAndDevelopmentExpense"/>
<link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingExpenses" xlink:to="loc_us-gaapResearchAndDevelopmentExpense" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GeneralAndAdministrativeExpense" xlink:label="loc_us-gaapGeneralAndAdministrativeExpense"/>
<link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingExpenses" xlink:to="loc_us-gaapGeneralAndAdministrativeExpense" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaapOperatingIncomeLoss"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:label="loc_us-gaapRevenueFromContractWithCustomerExcludingAssessedTax"/>
<link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingIncomeLoss" xlink:to="loc_us-gaapRevenueFromContractWithCustomerExcludingAssessedTax" xlink:type="arc" weight="1"/>
<link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingIncomeLoss" xlink:to="loc_us-gaapOperatingExpenses" xlink:type="arc" weight="-1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_us-gaapNonoperatingIncomeExpense"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InvestmentIncomeInterest" xlink:label="loc_us-gaapInvestmentIncomeInterest"/>
<link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNonoperatingIncomeExpense" xlink:to="loc_us-gaapInvestmentIncomeInterest" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestExpense" xlink:label="loc_us-gaapInterestExpense"/>
<link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNonoperatingIncomeExpense" xlink:to="loc_us-gaapInterestExpense" xlink:type="arc" weight="-1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="loc_us-gaapOtherNonoperatingIncomeExpense"/>
<link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNonoperatingIncomeExpense" xlink:to="loc_us-gaapOtherNonoperatingIncomeExpense" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:label="loc_us-gaapIncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
<link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapIncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:to="loc_us-gaapOperatingIncomeLoss" xlink:type="arc" weight="1"/>
<link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapIncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:to="loc_us-gaapNonoperatingIncomeExpense" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaapNetIncomeLoss"/>
<link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetIncomeLoss" xlink:to="loc_us-gaapIncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_us-gaapIncomeTaxExpenseBenefit"/>
<link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetIncomeLoss" xlink:to="loc_us-gaapIncomeTaxExpenseBenefit" xlink:type="arc" weight="-1"/>
</link:calculationLink>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/StatementsOfChangesInShareholdersEquity" xlink:title="00000005 - Statement - Consolidated Statements of Changes in Shareholders&apos; Equity"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/StatementsOfCashFlows" xlink:title="00000006 - Statement - Consolidated Statements of Cash Flows">
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaapNetCashProvidedByUsedInOperatingActivities"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaapNetIncomeLoss"/>
<link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapNetIncomeLoss" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="ogen-20231231.xsd#OGEN_WriteOffOfInProcessResearchAndDevelopment" xlink:label="loc_OGENWriteOffOfInProcessResearchAndDevelopment"/>
<link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_OGENWriteOffOfInProcessResearchAndDevelopment" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DepreciationAndAmortization" xlink:label="loc_us-gaapDepreciationAndAmortization"/>
<link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapDepreciationAndAmortization" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GainLossOnSaleOfPropertyPlantEquipment" xlink:label="loc_us-gaapGainLossOnSaleOfPropertyPlantEquipment"/>
<link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapGainLossOnSaleOfPropertyPlantEquipment" xlink:type="arc" weight="-1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaapShareBasedCompensation"/>
<link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapShareBasedCompensation" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInOtherReceivables" xlink:label="loc_us-gaapIncreaseDecreaseInOtherReceivables"/>
<link:calculationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInOtherReceivables" xlink:type="arc" weight="-1"/>
<link:loc xlink:type="locator" xlink:href="ogen-20231231.xsd#OGEN_IncreaseDecreaseInOperatingLeaseRightOfUseAssets" xlink:label="loc_OGENIncreaseDecreaseInOperatingLeaseRightOfUseAssets"/>
<link:calculationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_OGENIncreaseDecreaseInOperatingLeaseRightOfUseAssets" xlink:type="arc" weight="-1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:label="loc_us-gaapIncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
<link:calculationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:type="arc" weight="-1"/>
<link:loc xlink:type="locator" xlink:href="ogen-20231231.xsd#OGEN_IncreaseDecreaseInPrepaidResearchAndDevelopment" xlink:label="loc_OGENIncreaseDecreaseInPrepaidResearchAndDevelopment"/>
<link:calculationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_OGENIncreaseDecreaseInPrepaidResearchAndDevelopment" xlink:type="arc" weight="-1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInOperatingLeaseLiability" xlink:label="loc_us-gaapIncreaseDecreaseInOperatingLeaseLiability"/>
<link:calculationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInOperatingLeaseLiability" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities" xlink:label="loc_us-gaapIncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
<link:calculationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInAccountsPayableAndAccruedLiabilities" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaapNetCashProvidedByUsedInInvestingActivities"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment" xlink:label="loc_us-gaapProceedsFromSaleOfPropertyPlantAndEquipment"/>
<link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInInvestingActivities" xlink:to="loc_us-gaapProceedsFromSaleOfPropertyPlantAndEquipment" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquireInProcessResearchAndDevelopment" xlink:label="loc_us-gaapPaymentsToAcquireInProcessResearchAndDevelopment"/>
<link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInInvestingActivities" xlink:to="loc_us-gaapPaymentsToAcquireInProcessResearchAndDevelopment" xlink:type="arc" weight="-1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" xlink:label="loc_us-gaapPaymentsToAcquirePropertyPlantAndEquipment"/>
<link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInInvestingActivities" xlink:to="loc_us-gaapPaymentsToAcquirePropertyPlantAndEquipment" xlink:type="arc" weight="-1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaapNetCashProvidedByUsedInFinancingActivities"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RepaymentsOfShortTermDebt" xlink:label="loc_us-gaapRepaymentsOfShortTermDebt"/>
<link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_us-gaapRepaymentsOfShortTermDebt" xlink:type="arc" weight="-1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromIssuanceOfPrivatePlacement" xlink:label="loc_us-gaapProceedsFromIssuanceOfPrivatePlacement"/>
<link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_us-gaapProceedsFromIssuanceOfPrivatePlacement" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:label="loc_us-gaapCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
<link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:to="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:type="arc" weight="1"/>
<link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:to="loc_us-gaapNetCashProvidedByUsedInInvestingActivities" xlink:type="arc" weight="1"/>
<link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:to="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:type="arc" weight="1"/>
</link:calculationLink>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/BasisOfPresentation" xlink:title="995512 - Disclosure - Basis of Presentation"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/SignificantAccountingPolicies" xlink:title="995513 - Disclosure - Significant Accounting Policies"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/AcquisitionOfConcussionAssets" xlink:title="995514 - Disclosure - Acquisition of Concussion Assets"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/PropertyAndEquipmentNet" xlink:title="995515 - Disclosure - Property and Equipment, net"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/AccountsPayableAndAccruedExpenses" xlink:title="995516 - Disclosure - Accounts Payable and Accrued Expenses"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/Short-termNotesPayable" xlink:title="995517 - Disclosure - Short-Term Notes Payable"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/PrepaidExpenseAssetsCurrentAndLong-term" xlink:title="995518 - Disclosure - Prepaid Expense Assets &#8211; Current and Long-Term"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/ShareholdersEquity" xlink:title="995519 - Disclosure - Shareholders&#8217; Equity"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/StockCompensationPlan" xlink:title="995520 - Disclosure - Stock Compensation Plan"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/RetirementPlan" xlink:title="995521 - Disclosure - Retirement Plan"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/IncomeTaxes" xlink:title="995522 - Disclosure - Income Taxes"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/CommitmentsAndContingencies" xlink:title="995523 - Disclosure - Commitments and Contingencies"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/SubsequentEvents" xlink:title="995524 - Disclosure - Subsequent Events"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/SignificantAccountingPoliciesPolicies" xlink:title="995525 - Disclosure - Significant Accounting Policies (Policies)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/AcquisitionOfConcussionAssetsTables" xlink:title="995526 - Disclosure - Acquisition of Concussion Assets (Tables)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/PropertyAndEquipmentNetTables" xlink:title="995527 - Disclosure - Property and Equipment, net (Tables)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/AccountsPayableAndAccruedExpensesTables" xlink:title="995528 - Disclosure - Accounts Payable and Accrued Expenses (Tables)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/Short-termNotesPayableTables" xlink:title="995529 - Disclosure - Short-Term Notes Payable (Tables)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/PrepaidExpenseAssetsCurrentAndLong-termTables" xlink:title="995530 - Disclosure - Prepaid Expense Assets &#8211; Current and Long-Term (Tables)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/ShareholdersEquityTables" xlink:title="995531 - Disclosure - Shareholders&#8217; Equity (Tables)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/StockCompensationPlanTables" xlink:title="995532 - Disclosure - Stock Compensation Plan (Tables)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/IncomeTaxesTables" xlink:title="995533 - Disclosure - Income Taxes (Tables)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/CommitmentsAndContingenciesTables" xlink:title="995534 - Disclosure - Commitments and Contingencies (Tables)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/BasisOfPresentationDetailsNarrative" xlink:title="995535 - Disclosure - Basis of Presentation (Details Narrative)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/SignificantAccountingPoliciesDetailsNarrative" xlink:title="995536 - Disclosure - Significant Accounting Policies (Details Narrative)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/ScheduleOfAcquisitionOfAssetsDetails" xlink:title="995537 - Disclosure - Schedule of Acquisition of Assets (Details)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/AcquisitionOfConcussionAssetsDetailsNarrative" xlink:title="995538 - Disclosure - Acquisition of Concussion Assets (Details Narrative)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/SummaryOfPropertyAndEquipmentNetDetails" xlink:title="995539 - Disclosure - Summary of Property and Equipment, Net (Details)">
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaapPropertyPlantAndEquipmentNet"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentGross" xlink:label="loc_us-gaapPropertyPlantAndEquipmentGross"/>
<link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapPropertyPlantAndEquipmentNet" xlink:to="loc_us-gaapPropertyPlantAndEquipmentGross" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:label="loc_us-gaapAccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
<link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapPropertyPlantAndEquipmentNet" xlink:to="loc_us-gaapAccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:type="arc" weight="-1"/>
</link:calculationLink>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/PropertyAndEquipmentNetDetailsNarrative" xlink:title="995540 - Disclosure - Property and Equipment, net (Details Narrative)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/SummaryOfAccountsPayableAndAccruedExpensesDetails" xlink:title="995541 - Disclosure - Summary of Accounts Payable and Accrued Expenses (Details)">
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent" xlink:label="loc_us-gaapAccountsPayableAndAccruedLiabilitiesCurrent"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsPayableTradeCurrent" xlink:label="loc_us-gaapAccountsPayableTradeCurrent"/>
<link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAccountsPayableAndAccruedLiabilitiesCurrent" xlink:to="loc_us-gaapAccountsPayableTradeCurrent" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccruedLiabilitiesCurrent" xlink:label="loc_us-gaapAccruedLiabilitiesCurrent"/>
<link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAccountsPayableAndAccruedLiabilitiesCurrent" xlink:to="loc_us-gaapAccruedLiabilitiesCurrent" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccruedProfessionalFeesCurrent" xlink:label="loc_us-gaapAccruedProfessionalFeesCurrent"/>
<link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAccountsPayableAndAccruedLiabilitiesCurrent" xlink:to="loc_us-gaapAccruedProfessionalFeesCurrent" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccruedVacationCurrent" xlink:label="loc_us-gaapAccruedVacationCurrent"/>
<link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAccountsPayableAndAccruedLiabilitiesCurrent" xlink:to="loc_us-gaapAccruedVacationCurrent" xlink:type="arc" weight="1"/>
</link:calculationLink>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/SummaryOfShort-termNotesPayableDetails" xlink:title="995542 - Disclosure - Summary of Short-Term Notes payable (Details)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/SummaryOfShort-termNotesPayableDetailsParenthetical" xlink:title="995543 - Disclosure - Summary of Short-Term Notes payable (Details) (Parenthetical)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/ScheduleOfExpenseAndOtherCurrentAssetsDetails" xlink:title="995544 - Disclosure - Schedule of Expense and Other Current Assets (Details)">
<link:loc xlink:type="locator" xlink:href="ogen-20231231.xsd#OGEN_CurrentAndLongTermPrepaidAssets" xlink:label="loc_OGENCurrentAndLongTermPrepaidAssets"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PrepaidExpenseCurrent" xlink:label="loc_us-gaapPrepaidExpenseCurrent"/>
<link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_OGENCurrentAndLongTermPrepaidAssets" xlink:to="loc_us-gaapPrepaidExpenseCurrent" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PrepaidInsurance" xlink:label="loc_us-gaapPrepaidInsurance"/>
<link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_OGENCurrentAndLongTermPrepaidAssets" xlink:to="loc_us-gaapPrepaidInsurance" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherPrepaidExpenseCurrent" xlink:label="loc_us-gaapOtherPrepaidExpenseCurrent"/>
<link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_OGENCurrentAndLongTermPrepaidAssets" xlink:to="loc_us-gaapOtherPrepaidExpenseCurrent" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DepositsAssetsCurrent" xlink:label="loc_us-gaapDepositsAssetsCurrent"/>
<link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_OGENCurrentAndLongTermPrepaidAssets" xlink:to="loc_us-gaapDepositsAssetsCurrent" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="ogen-20231231.xsd#OGEN_PrepaidResearchAndDevelopmentExpense" xlink:label="loc_OGENPrepaidResearchAndDevelopmentExpense"/>
<link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_OGENCurrentAndLongTermPrepaidAssets" xlink:to="loc_OGENPrepaidResearchAndDevelopmentExpense" xlink:type="arc" weight="1"/>
</link:calculationLink>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/ScheduleOfWarrantsOutstandingAndExercisableDetails" xlink:title="995545 - Disclosure - Schedule of Warrants Outstanding and Exercisable (Details)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/ShareholdersEquityDetailsNarrative" xlink:title="995546 - Disclosure - Shareholders&#8217; Equity (Details Narrative)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/SummaryOfAssumptionsUsedToEstimateFairValueOfStockOptionsGrantedDetails" xlink:title="995547 - Disclosure - Summary of Assumptions Used to Estimate the Fair Value of Stock Options Granted (Details)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/SummaryOfStockOptionActivityDetails" xlink:title="995548 - Disclosure - Summary of Stock Option Activity (Details)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/SummaryOfWeightedAverageGrantFairValueOfStockOptionsDetails" xlink:title="995549 - Disclosure - Summary of Weighted Average Grant Fair Value of Stock Options (Details)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/ScheduleOfRestrictedStockActivityDetails" xlink:title="995550 - Disclosure - Schedule of Restricted Stock Activity (Details)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/StockCompensationPlanDetailsNarrative" xlink:title="995551 - Disclosure - Stock Compensation Plan (Details Narrative)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/RetirementPlanDetailsNarrative" xlink:title="995552 - Disclosure - Retirement Plan (Details Narrative)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/ScheduleOfComponentsOfProvisionForIncomeTaxesDetails" xlink:title="995553 - Disclosure - Schedule of Components of Provision for Income Taxes (Details)">
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_us-gaapIncomeTaxExpenseBenefit"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit" xlink:label="loc_us-gaapCurrentIncomeTaxExpenseBenefit"/>
<link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapIncomeTaxExpenseBenefit" xlink:to="loc_us-gaapCurrentIncomeTaxExpenseBenefit" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit" xlink:label="loc_us-gaapDeferredIncomeTaxExpenseBenefit"/>
<link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapIncomeTaxExpenseBenefit" xlink:to="loc_us-gaapDeferredIncomeTaxExpenseBenefit" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount" xlink:label="loc_us-gaapValuationAllowanceDeferredTaxAssetChangeInAmount"/>
<link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapIncomeTaxExpenseBenefit" xlink:to="loc_us-gaapValuationAllowanceDeferredTaxAssetChangeInAmount" xlink:type="arc" weight="-1"/>
</link:calculationLink>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/SummaryOfComponentsOfDeferredTaxDetails" xlink:title="995554 - Disclosure - Summary of Components of Deferred Tax (Details)">
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsGross" xlink:label="loc_us-gaapDeferredTaxAssetsGross"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwards" xlink:label="loc_us-gaapDeferredTaxAssetsOperatingLossCarryforwards"/>
<link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapDeferredTaxAssetsGross" xlink:to="loc_us-gaapDeferredTaxAssetsOperatingLossCarryforwards" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsCompensatedAbsences" xlink:label="loc_us-gaapDeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsCompensatedAbsences"/>
<link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapDeferredTaxAssetsGross" xlink:to="loc_us-gaapDeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsCompensatedAbsences" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost" xlink:label="loc_us-gaapDeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost"/>
<link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapDeferredTaxAssetsGross" xlink:to="loc_us-gaapDeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsInProcessResearchAndDevelopment" xlink:label="loc_us-gaapDeferredTaxAssetsInProcessResearchAndDevelopment"/>
<link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapDeferredTaxAssetsGross" xlink:to="loc_us-gaapDeferredTaxAssetsInProcessResearchAndDevelopment" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsGoodwillAndIntangibleAssets" xlink:label="loc_us-gaapDeferredTaxAssetsGoodwillAndIntangibleAssets"/>
<link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapDeferredTaxAssetsGross" xlink:to="loc_us-gaapDeferredTaxAssetsGoodwillAndIntangibleAssets" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsNet" xlink:label="loc_us-gaapDeferredTaxAssetsNet"/>
<link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapDeferredTaxAssetsNet" xlink:to="loc_us-gaapDeferredTaxAssetsGross" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsValuationAllowance" xlink:label="loc_us-gaapDeferredTaxAssetsValuationAllowance"/>
<link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapDeferredTaxAssetsNet" xlink:to="loc_us-gaapDeferredTaxAssetsValuationAllowance" xlink:type="arc" weight="-1"/>
</link:calculationLink>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/ScheduleOfReconciliationOfTaxComputedAtStatutoryFederalRateDetails" xlink:title="995555 - Disclosure - Schedule of Reconciliation of Tax Computed at Statutory Federal Rate (Details)">
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_us-gaapIncomeTaxExpenseBenefit"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate" xlink:label="loc_us-gaapIncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate"/>
<link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapIncomeTaxExpenseBenefit" xlink:to="loc_us-gaapIncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes" xlink:label="loc_us-gaapIncomeTaxReconciliationStateAndLocalIncomeTaxes"/>
<link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapIncomeTaxExpenseBenefit" xlink:to="loc_us-gaapIncomeTaxReconciliationStateAndLocalIncomeTaxes" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxReconciliationPriorYearIncomeTaxes" xlink:label="loc_us-gaapIncomeTaxReconciliationPriorYearIncomeTaxes"/>
<link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapIncomeTaxExpenseBenefit" xlink:to="loc_us-gaapIncomeTaxReconciliationPriorYearIncomeTaxes" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance" xlink:label="loc_us-gaapIncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance"/>
<link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapIncomeTaxExpenseBenefit" xlink:to="loc_us-gaapIncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxReconciliationNondeductibleExpense" xlink:label="loc_us-gaapIncomeTaxReconciliationNondeductibleExpense"/>
<link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapIncomeTaxExpenseBenefit" xlink:to="loc_us-gaapIncomeTaxReconciliationNondeductibleExpense" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxReconciliationOtherReconcilingItems" xlink:label="loc_us-gaapIncomeTaxReconciliationOtherReconcilingItems"/>
<link:calculationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapIncomeTaxExpenseBenefit" xlink:to="loc_us-gaapIncomeTaxReconciliationOtherReconcilingItems" xlink:type="arc" weight="1"/>
</link:calculationLink>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/ScheduleOfReconciliationOfTaxComputedAtStatutoryFederalRateDetailsParenthetical" xlink:title="995556 - Disclosure - Schedule of Reconciliation of Tax Computed at Statutory Federal Rate (Details) (Parenthetical)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/ScheduleOfReconciliationOfUnrecognizedTaxBenefitsDetails" xlink:title="995557 - Disclosure - Schedule of Reconciliation of Unrecognized Tax Benefits (Details)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/IncomeTaxesDetailsNarrative" xlink:title="995558 - Disclosure - Income Taxes (Details Narrative)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/ScheduleOfSupplementalBalanceSheetInformationRelatedToLeasesDetails" xlink:title="995559 - Disclosure - Schedule of Supplemental Balance Sheet Information Related to Leases (Details)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/ScheduleOfOperatingLeaseLiabilitiesDetails" xlink:title="995560 - Disclosure - Schedule of Operating lease liabilities (Details)">
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue" xlink:label="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDue"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths" xlink:label="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
<link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDue" xlink:to="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths" xlink:type="arc" weight="1"/>
</link:calculationLink>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/ScheduleOfCostComponentOfOperatingLeasesDetails" xlink:title="995561 - Disclosure - Schedule of Cost Component of Operating Leases (Details)">
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LeaseCost" xlink:label="loc_us-gaapLeaseCost"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseCost" xlink:label="loc_us-gaapOperatingLeaseCost"/>
<link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLeaseCost" xlink:to="loc_us-gaapOperatingLeaseCost" xlink:type="arc" weight="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShortTermLeaseCost" xlink:label="loc_us-gaapShortTermLeaseCost"/>
<link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLeaseCost" xlink:to="loc_us-gaapShortTermLeaseCost" xlink:type="arc" weight="1"/>
</link:calculationLink>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/ScheduleOfSupplementalCashFlowInformationRelatedToOperatingLeasesDetails" xlink:title="995562 - Disclosure - Schedule of Supplemental Cash Flow Information Related to Operating Leases (Details)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/CommitmentsAndContingenciesDetailsNarrative" xlink:title="995563 - Disclosure - Commitments and Contingencies (Details Narrative)"/>
<link:calculationLink xlink:type="extended" xlink:role="http://oragenics.com/role/SubsequentEventsDetailsNarrative" xlink:title="995564 - Disclosure - Subsequent Events (Details Narrative)"/>
</link:linkbase>


31 Previous Filings that this Filing References

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

12/29/23  Oragenics Inc.                    8-K:2,5,9  12/28/23   11:384K                                   M2 Compliance LLC/FA
12/15/23  Oragenics Inc.                    8-K:3,5,9  12/14/23   13:517K                                   M2 Compliance LLC/FA
12/08/23  Oragenics Inc.                    8-K:5,9    12/04/23   11:335K                                   M2 Compliance LLC/FA
 3/08/23  Oragenics Inc.                    8-K:5,9     3/07/23   12:391K                                   M2 Compliance LLC/FA
 1/23/23  Oragenics Inc.                    8-K:3,5,9   1/20/23   12:2.5M                                   M2 Compliance LLC/FA
 6/23/22  Oragenics Inc.                    8-K:5,9     6/23/22   12:417K                                   M2 Compliance LLC/FA
 3/24/22  Oragenics Inc.                    10-K       12/31/21   77:7M                                     M2 Compliance LLC/FA
 2/28/22  Oragenics Inc.                    8-K:3,5,9   2/25/22   16:777K                                   M2 Compliance LLC/FA
11/15/21  Oragenics Inc.                    10-Q        9/30/21   49:3.7M                                   M2 Compliance LLC/FA
 8/14/20  Oragenics Inc.                    10-Q        6/30/20   54:3M                                     M2 Compliance LLC/FA
 5/04/20  Oragenics Inc.                    8-K:1,2,3,5 5/01/20    5:676K                                   M2 Compliance LLC/FA
 3/04/20  Oragenics Inc.                    10-K       12/31/19   75:5.4M                                   M2 Compliance LLC/FA
 6/21/19  Oragenics Inc.                    8-K:5,9     6/20/19    2:39K                                    Donnelley … Solutions/FA
 7/17/18  Oragenics Inc.                    8-K:1,5,8,9 7/13/18    6:485K                                   Donnelley … Solutions/FA
 7/09/18  Oragenics Inc.                    S-1/A       7/06/18    6:1M                                     Donnelley … Solutions/FA
 6/26/18  Oragenics Inc.                    8-K:5,9     6/22/18    3:47K                                    Donnelley … Solutions/FA
 4/10/18  Oragenics Inc.                    8-K:1,3,9   4/06/18    6:386K                                   Donnelley … Solutions/FA
 1/19/18  Oragenics Inc.                    8-K:3,5,9   1/19/18    2:28K                                    Donnelley … Solutions/FA
12/29/17  Oragenics Inc.                    8-K:5,8,9  12/29/17    4:212K                                   Donnelley … Solutions/FA
11/09/17  Oragenics Inc.                    8-K:1,3,5,811/08/17   13:688K                                   Donnelley … Solutions/FA
 8/01/17  Oragenics Inc.                    8-K:1,3,9   7/27/17    3:209K                                   Donnelley … Solutions/FA
 5/05/17  Oragenics Inc.                    8-K:5,9     5/04/17    2:31K                                    Donnelley … Solutions/FA
 3/18/15  Oragenics Inc.                    8-K:5,9     3/16/15    4:109K                                   Donnelley … Solutions/FA
 8/07/14  Oragenics Inc.                    10-Q        6/30/14   46:2.2M                                   Donnelley … Solutions/FA
 3/26/13  Oragenics Inc.                    10-K       12/31/12   74:5.9M                                   Donnelley … Solutions/FA
10/25/12  Oragenics Inc.                    8-K:5,9    10/23/12    2:134K                                   Donnelley … Solutions/FA
 4/16/12  Oragenics Inc.                    10-K       12/31/11   39:3M                                     Donnelley … Solutions/FA
11/14/11  Oragenics Inc.                    10-Q        9/30/11   28:1M                                     Donnelley … Solutions/FA
 8/24/10  Oragenics Inc.                    8-K:5,9     8/20/10    2:19K                                    Donnelley … Solutions/FA
 6/09/10  Oragenics Inc.                    8-K:5,9     6/04/10    3:79K                                    Toppan Merrill/FA
10/16/02  Oragenics Inc.                    SB-2                  45:1.3M                                   Law Office of Con… PS/FA
Top
Filing Submission 0001493152-24-011979   –   Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)

Copyright © 2024 Fran Finnegan & Company LLC – All Rights Reserved.
AboutPrivacyRedactionsHelp — Thu., May 16, 9:16:12.3am ET