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Creative Medical Technology Holdings, Inc. – ‘10-Q’ for 6/30/22 – ‘EX-101.DEF’

On:  Friday, 8/12/22, at 4:46pm ET   ·   For:  6/30/22   ·   Accession #:  1477932-22-5931   ·   File #:  1-41120

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  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 8/12/22  Creative Medical Tech Holdin… Inc 10-Q        6/30/22   46:3.3M                                   Discount Edgar/FA

Quarterly Report   —   Form 10-Q

Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-Q        Quarterly Report                                    HTML    870K 
 2: EX-31.1     Certification -- §302 - SOA'02                      HTML     19K 
 3: EX-31.2     Certification -- §302 - SOA'02                      HTML     19K 
 4: EX-32.1     Certification -- §906 - SOA'02                      HTML     15K 
 5: EX-32.2     Certification -- §906 - SOA'02                      HTML     15K 
11: R1          Cover                                               HTML     62K 
12: R2          Condensed Consolidated Balance Sheets               HTML     87K 
13: R3          Condensed Consolidated Balance Sheets               HTML     23K 
                (Parenthetical)                                                  
14: R4          Unaudited Condensed Consolidated Statements of      HTML    100K 
                Operations                                                       
15: R5          Unaudited Condensed Consolidated Statements of      HTML     96K 
                Cash Flows                                                       
16: R6          Unaudited Condensed Consolidated Statements of      HTML     83K 
                Stockholders' Equity (Deficit)                                   
17: R7          Organization and Summary of Significant Accounting  HTML     43K 
                Policies                                                         
18: R8          Licensing Agreements                                HTML     38K 
19: R9          Related Party Transactions                          HTML     23K 
20: R10         Debt                                                HTML     22K 
21: R11         Derivative Liabilities                              HTML     19K 
22: R12         Stockbased Compensation                             HTML     34K 
23: R13         Stockholders Equity                                 HTML     26K 
24: R14         Subsequent Events                                   HTML     17K 
25: R15         Organization and Summary of Significant Accounting  HTML     63K 
                Policies (Policies)                                              
26: R16         Organization and Summary of Significant Accounting  HTML     24K 
                Policies (Tables)                                                
27: R17         Licensing Agreements (Tables)                       HTML     22K 
28: R18         Stockbased Compensation (Tables)                    HTML     34K 
29: R19         Stockholders Equity (Tables)                        HTML     18K 
30: R20         Organization and Summary of Significant Accounting  HTML     40K 
                Policies (Details)                                               
31: R21         Organization and Summary of Significant Accounting  HTML     21K 
                Policies (Details Narrative)                                     
32: R22         Licensing Agreements (Details)                      HTML     27K 
33: R23         Licensing Agreements (Details Narrative)            HTML     89K 
34: R24         Related Party Transactions (Details Narrative)      HTML     60K 
35: R25         Debt (Details Narrative)                            HTML     51K 
36: R26         Derivative Liabilities (Details Narrative)          HTML     50K 
37: R27         Stockbased Compensation (Details)                   HTML     25K 
38: R28         Stockbased Compensation (Details 1)                 HTML     43K 
39: R29         Stockbased Compensation (Details Narrative)         HTML     30K 
40: R30         Stockholders Equity (Details)                       HTML     24K 
41: R31         Stockholders Equity (Details Narrative)             HTML     30K 
44: XML         IDEA XML File -- Filing Summary                      XML     74K 
42: XML         XBRL Instance -- celz_10q_htm                        XML    688K 
43: EXCEL       IDEA Workbook of Financial Reports                  XLSX     77K 
 8: EX-101.CAL  XBRL Calculations -- celz-20220630_cal               XML    100K 
10: EX-101.DEF  XBRL Definitions -- celz-20220630_def                XML    293K 
 7: EX-101.LAB  XBRL Labels -- celz-20220630_lab                     XML    604K 
 9: EX-101.PRE  XBRL Presentations -- celz-20220630_pre              XML    468K 
 6: EX-101.SCH  XBRL Schema -- celz-20220630                         XSD    133K 
45: JSON        XBRL Instance as JSON Data -- MetaLinks              239±   326K 
46: ZIP         XBRL Zipped Folder -- 0001477932-22-005931-xbrl      Zip    161K

‘EX-101.DEF’   —   XBRL Definitions — celz-20220630_def

This Exhibit is an XBRL XML File.

                                                                                                                                                                                
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<link:loc xlink:type="locator" xlink:href="celz-20220630.xsd#celz_WarrantsMember" xlink:label="loc_celzWarrantsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapAntidilutiveSecuritiesNameDomain" xlink:to="loc_celzWarrantsMember" order="11"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xlink:label="loc_us-gaapShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStatementLineItems" xlink:to="loc_us-gaapShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" order="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross" xlink:label="loc_us-gaapShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStatementLineItems" xlink:to="loc_us-gaapShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross" order="2"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xlink:label="loc_us-gaapStockIssuedDuringPeriodSharesStockOptionsExercised"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStatementLineItems" xlink:to="loc_us-gaapStockIssuedDuringPeriodSharesStockOptionsExercised" order="3"/>
<link:loc xlink:type="locator" xlink:href="celz-20220630.xsd#celz_WeightedAverageExercisePriceOutstandingEnding" xlink:label="loc_celzWeightedAverageExercisePriceOutstandingEnding"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStatementLineItems" xlink:to="loc_celzWeightedAverageExercisePriceOutstandingEnding" order="4"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://celz.com/role/StockholdersEquityDetailsNarrative" xlink:title="000031 - Disclosure - STOCKHOLDERS EQUITY (Details Narrative)">
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaapStatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaapStatementTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaapStatementLineItems" xlink:to="loc_us-gaapStatementTable" order="2000" xbrldt:contextElement="segment" xbrldt:closed="true"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionAxis" xlink:label="loc_us-gaapRelatedPartyTransactionAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaapStatementTable" xlink:to="loc_us-gaapRelatedPartyTransactionAxis" order="10"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionDomain" xlink:label="loc_us-gaapRelatedPartyTransactionDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaapRelatedPartyTransactionAxis" xlink:to="loc_us-gaapRelatedPartyTransactionDomain" order="20"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionDomain" xlink:label="loc_us-gaapRelatedPartyTransactionDomain_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaapRelatedPartyTransactionAxis" xlink:to="loc_us-gaapRelatedPartyTransactionDomain_10" order="30" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="celz-20220630.xsd#celz_RothCapitalPartnersMember" xlink:label="loc_celzRothCapitalPartnersMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapRelatedPartyTransactionDomain" xlink:to="loc_celzRothCapitalPartnersMember" order="11"/>
<link:loc xlink:type="locator" xlink:href="celz-20220630.xsd#celz_DescriptionOfAmendment" xlink:label="loc_celzDescriptionOfAmendment"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStatementLineItems" xlink:to="loc_celzDescriptionOfAmendment" order="1"/>
<link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockCapitalSharesReservedForFutureIssuance" xlink:label="loc_us-gaapCommonStockCapitalSharesReservedForFutureIssuance"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStatementLineItems" xlink:to="loc_us-gaapCommonStockCapitalSharesReservedForFutureIssuance" order="2"/>
<link:loc xlink:type="locator" xlink:href="celz-20220630.xsd#celz_PreFundedWarrantsExercisePrice" xlink:label="loc_celzPreFundedWarrantsExercisePrice"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStatementLineItems" xlink:to="loc_celzPreFundedWarrantsExercisePrice" order="3"/>
<link:loc xlink:type="locator" xlink:href="celz-20220630.xsd#celz_PurchaseOfWarrantsShares" xlink:label="loc_celzPurchaseOfWarrantsShares"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStatementLineItems" xlink:to="loc_celzPurchaseOfWarrantsShares" order="4"/>
<link:loc xlink:type="locator" xlink:href="celz-20220630.xsd#celz_PurchaseOfPreFundedWarrantAndRelatedCommonWarrant" xlink:label="loc_celzPurchaseOfPreFundedWarrantAndRelatedCommonWarrant"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStatementLineItems" xlink:to="loc_celzPurchaseOfPreFundedWarrantAndRelatedCommonWarrant" order="5"/>
<link:loc xlink:type="locator" xlink:href="celz-20220630.xsd#celz_CommonWarrantsTerm" xlink:label="loc_celzCommonWarrantsTerm"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStatementLineItems" xlink:to="loc_celzCommonWarrantsTerm" order="6"/>
<link:loc xlink:type="locator" xlink:href="celz-20220630.xsd#celz_CommonWarrantsExercisePrice" xlink:label="loc_celzCommonWarrantsExercisePrice"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStatementLineItems" xlink:to="loc_celzCommonWarrantsExercisePrice" order="7"/>
<link:loc xlink:type="locator" xlink:href="celz-20220630.xsd#celz_CombinedOfferingPriceOfPreFundedWarrantAndRelatedCommonWarrant" xlink:label="loc_celzCombinedOfferingPriceOfPreFundedWarrantAndRelatedCommonWarrant"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStatementLineItems" xlink:to="loc_celzCombinedOfferingPriceOfPreFundedWarrantAndRelatedCommonWarrant" order="8"/>
<link:loc xlink:type="locator" xlink:href="celz-20220630.xsd#celz_PaidPlacementAgentFee" xlink:label="loc_celzPaidPlacementAgentFee"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStatementLineItems" xlink:to="loc_celzPaidPlacementAgentFee" order="9"/>
<link:loc xlink:type="locator" xlink:href="celz-20220630.xsd#celz_IssuedWarrantToPurchaseSharesOfCommonStock" xlink:label="loc_celzIssuedWarrantToPurchaseSharesOfCommonStock"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaapStatementLineItems" xlink:to="loc_celzIssuedWarrantToPurchaseSharesOfCommonStock" order="10"/>
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</link:linkbase>

7 Previous Filings that this Filing References

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

11/09/21  Creative Medical Tech Holdin… Inc 8-K:3,5,8,911/08/21   14:504K                                   Discount Edgar/FA
11/05/21  Creative Medical Tech Holdin… Inc 8-K:3,5,9  11/02/21   15:1.5M                                   Discount Edgar/FA
 4/02/21  Creative Medical Tech Holdin… Inc 8-K:1,3,5,9 3/30/21    3:648K                                   Discount Edgar/FA
 3/17/21  Creative Medical Tech Holdin… Inc 10-K       12/31/20   60:8.3M                                   Discount Edgar/FA
 3/12/21  Creative Medical Tech Holdin… Inc 8-K:3,5,8,9 3/11/21    3:518K                                   Discount Edgar/FA
 1/16/18  Creative Medical Tech Holdin… Inc 8-K:1,5,9   1/12/18    2:47K                                    Toppan Merrill/FA
11/18/08  Creative Medical Tech Holdin… Inc 10-12G                 6:516K                                   Action Edgar Fil… Svc/FA
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