SEC Info℠  
    Home      Search      My Interests      Help      Sign In      Please Sign In

Cryoport, Inc. – ‘10-Q’ for 6/30/22 – ‘EX-101.SCH’

On:  Thursday, 8/4/22, at 5:04pm ET   ·   For:  6/30/22   ·   Accession #:  1410578-22-2045   ·   File #:  1-34632

Previous ‘10-Q’:  ‘10-Q’ on 5/5/22 for 3/31/22   ·   Next:  ‘10-Q’ on 11/4/22 for 9/30/22   ·   Latest:  ‘10-Q’ on 11/9/23 for 9/30/23

Find Words in Filings emoji
 		  in    Show  and   ↓Hints

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 8/04/22  Cryoport, Inc.                    10-Q        6/30/22   91:11M                                    Toppan Merrill/FA2

Quarterly Report   —   Form 10-Q

Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-Q        Quarterly Report                                    HTML   2.63M 
 2: EX-31.1     Certification -- §302 - SOA'02                      HTML     31K 
 3: EX-31.2     Certification -- §302 - SOA'02                      HTML     31K 
 4: EX-32.1     Certification -- §906 - SOA'02                      HTML     30K 
10: R1          Document and Entity Information                     HTML     78K 
11: R2          Condensed Consolidated Balance Sheets               HTML    148K 
12: R3          Condensed Consolidated Balance Sheets               HTML     50K 
                (Parenthetical)                                                  
13: R4          Condensed Consolidated Statements of Operations     HTML    123K 
14: R5          Condensed Consolidated Statements of Comprehensive  HTML     56K 
                Loss                                                             
15: R6          Condensed Consolidated Statements of Stockholders'  HTML    121K 
                Equity                                                           
16: R7          Condensed Consolidated Statements of Stockholders'  HTML     27K 
                Equity (Parenthetical)                                           
17: R8          Condensed Consolidated Statements of Cash Flows     HTML    156K 
18: R9          Condensed Consolidated Statements of Cash Flows     HTML     27K 
                (Parenthetical)                                                  
19: R10         Management's Representation and Basis of            HTML     29K 
                Presentation                                                     
20: R11         Nature of the Business                              HTML     30K 
21: R12         Summary of Significant Accounting Policies          HTML    175K 
22: R13         Acquisitions                                        HTML     31K 
23: R14         Cash, Cash Equivalents and Short-Term Investments   HTML    126K 
24: R15         Fair Value Measurements                             HTML    119K 
25: R16         Inventory                                           HTML     39K 
26: R17         Goodwill and Intangible Assets                      HTML    132K 
27: R18         Convertible Senior Notes                            HTML     84K 
28: R19         Note Payable                                        HTML     71K 
29: R20         Leases                                              HTML     72K 
30: R21         Commitments and Contingencies                       HTML     33K 
31: R22         Stockholders' Equity                                HTML     58K 
32: R23         Stock-Based Compensation                            HTML    113K 
33: R24         Subsequent Events                                   HTML     29K 
34: R25         Summary of Significant Accounting Policies          HTML    247K 
                (Policies)                                                       
35: R26         Summary of Significant Accounting Policies          HTML    121K 
                (Tables)                                                         
36: R27         Cash, Cash Equivalents and Short-Term Investments   HTML    128K 
                (Tables)                                                         
37: R28         Fair Value Measurements (Tables)                    HTML    115K 
38: R29         Inventory (Tables)                                  HTML     40K 
39: R30         Goodwill and Intangible Assets (Tables)             HTML    139K 
40: R31         Convertible Senior Notes (Tables)                   HTML     57K 
41: R32         Notes Payable (Tables)                              HTML     72K 
42: R33         Leases (Tables)                                     HTML     76K 
43: R34         Stockholders' Equity (Tables)                       HTML     33K 
44: R35         Stock-Based Compensation (Tables)                   HTML    116K 
45: R36         Summary of Significant Accounting Policies -        HTML     41K 
                Disaggregates Our Revenues by Major Source                       
                (Details)                                                        
46: R37         Summary of Significant Accounting Policies -        HTML     41K 
                Disaggregation Our Geographical Revenues by Origin               
                (Details)                                                        
47: R38         Summary of Significant Accounting Policies -        HTML     63K 
                Earnings Per Share (Details)                                     
48: R39         Summary of Significant Accounting Policies -        HTML     42K 
                Antidilutive Shares (Details)                                    
49: R40         Summary of Significant Accounting Policies -        HTML    138K 
                Additional Information (Details)                                 
50: R41         Acquisition - Additional Information (Details)      HTML     54K 
51: R42         Cash, Cash Equivalents and Short-Term Investments   HTML     52K 
                (Details)                                                        
52: R43         Cash, Cash Equivalents and Short-Term Investments   HTML     38K 
                - Available-for-sale Investments (Details)                       
53: R44         Cash, Cash Equivalents and Short-Term Investments   HTML     47K 
                - Contractual Maturities (Details)                               
54: R45         Cash, Cash Equivalents and Short-Term Investments   HTML     30K 
                - Equity Investments (Details)                                   
55: R46         Cash, Cash Equivalents and Short-Term Investments   HTML     30K 
                - Additional Information (Details)                               
56: R47         Fair Value Measurements (Details)                   HTML     38K 
57: R48         Fair Value Measurements - Additional Information    HTML     29K 
                (Details)                                                        
58: R49         Fair Value Measurements - Estimated fair values     HTML     34K 
                and the carrying values (Details)                                
59: R50         Inventory (Details)                                 HTML     34K 
60: R51         Goodwill and Intangible Assets - Schedule of        HTML     42K 
                goodwill (Details)                                               
61: R52         Goodwill and Intangible Assets - Intangible Assets  HTML     55K 
                (Details)                                                        
62: R53         Goodwill and Intangible Assets - Expected Future    HTML     40K 
                Amortization (Details)                                           
63: R54         Goodwill and Intangible Assets - Additional         HTML     28K 
                Information (Details)                                            
64: R55         Convertible Senior Notes - Components of            HTML     34K 
                Convertible notes payable (Details)                              
65: R56         Convertible Senior Notes - Interest expenses        HTML     34K 
                incurred on Convertible notes payable (Details)                  
66: R57         Convertible Senior Notes - Additional information   HTML    115K 
                (Details)                                                        
67: R58         Notes Payable (Details)                             HTML     48K 
68: R59         Notes Payable - Interest expense (Details)          HTML     37K 
69: R60         Note Payable - CRYOPDP Note (Details)               HTML     47K 
70: R61         Notes Payable - Cell&Co Notes (Details)             HTML     36K 
71: R62         Notes Payable - Future note payments (Details)      HTML     52K 
72: R63         Leases - Components Of Lease Cost (Details)         HTML     27K 
73: R64         Leases - Supplemental Cash Flows Information        HTML     40K 
                (Details)                                                        
74: R65         Leases - Future Payments Under Non-Cancellable      HTML     48K 
                Leases (Details)                                                 
75: R66         Leases - Additional Information (Details)           HTML     30K 
76: R67         Commitments and Contingencies (Details)             HTML     37K 
77: R68         Stockholders' Equity - Common Stock Reserved for    HTML     39K 
                Future Issuance (Details)                                        
78: R69         Stockholders' Equity - Repurchase Program           HTML     34K 
                (Details)                                                        
79: R70         Stockholders' Equity - November 2021 Registered     HTML     42K 
                Direct Placement and Stock Purchase Agreements                   
                (Details)                                                        
80: R71         Stockholders' Equity - Additional Information       HTML    152K 
                (Details)                                                        
81: R72         Stock-Based Compensation - Assumptions Used to      HTML     43K 
                Estimate Fair Value of Stock Options (Details)                   
82: R73         Stock-Based Compensation - Stock-based              HTML     31K 
                Compensation Expense (Details)                                   
83: R74         Stock-Based Compensation - Stock Option Activity    HTML     82K 
                (Details)                                                        
84: R75         Stock-Based Compensation - Restricted stock unit    HTML     49K 
                (Details)                                                        
85: R76         Stock-Based Compensation - Additional Information   HTML     63K 
                (Details)                                                        
86: R77         Subsequent Events (Details)                         HTML     31K 
89: XML         IDEA XML File -- Filing Summary                      XML    169K 
87: XML         XBRL Instance -- cyrx-20220630x10q_htm               XML   2.90M 
88: EXCEL       IDEA Workbook of Financial Reports                  XLSX    189K 
 6: EX-101.CAL  XBRL Calculations -- cyrx-20220630_cal               XML    206K 
 7: EX-101.DEF  XBRL Definitions -- cyrx-20220630_def                XML    812K 
 8: EX-101.LAB  XBRL Labels -- cyrx-20220630_lab                     XML   1.58M 
 9: EX-101.PRE  XBRL Presentations -- cyrx-20220630_pre              XML   1.18M 
 5: EX-101.SCH  XBRL Schema -- cyrx-20220630                         XSD    220K 
90: JSON        XBRL Instance as JSON Data -- MetaLinks              475±   744K 
91: ZIP         XBRL Zipped Folder -- 0001410578-22-002045-xbrl      Zip    457K

‘EX-101.SCH’   —   XBRL Schema — cyrx-20220630

This Exhibit is an XBRL XML File.

                                                                                                                                                                                
<?xml version="1.0" encoding="windows-1252"?>
<!-- XBRL document created with Toppan Merrill Bridge 9.6.8167.22744 -->
<!-- Based on XBRL 2.1 -->
<!-- Created on: 8/4/2022 8:24:07 PM -->
<!-- Modified on: 8/4/2022 8:24:07 PM -->
<xsd:schema targetNamespace="http://www.Cryoport.com/20220630" elementFormDefault="qualified" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:cyrx="http://www.Cryoport.com/20220630" xmlns:deprecated="http://www.xbrl.org/2009/role/deprecated" xmlns:ref="http://www.xbrl.org/2006/ref" xmlns:us-roles="http://fasb.org/us-roles/2022" xmlns:currency="http://xbrl.sec.gov/currency/2022" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xl="http://www.xbrl.org/2003/XLink" xmlns:us-types="http://fasb.org/us-types/2022" xmlns:srt-roles="http://fasb.org/srt-roles/2022" xmlns:utr="http://www.xbrl.org/2009/utr" xmlns:us-gaap="http://fasb.org/us-gaap/2022" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:sic="http://xbrl.sec.gov/sic/2022" xmlns:stpr="http://xbrl.sec.gov/stpr/2022" xmlns:srt-types="http://fasb.org/srt-types/2022" xmlns:enum2="http://xbrl.org/2020/extensible-enumerations-2.0" xmlns:country="http://xbrl.sec.gov/country/2022" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:dei="http://xbrl.sec.gov/dei/2022" xmlns:naics="http://xbrl.sec.gov/naics/2022" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2020-01-21" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:exch="http://xbrl.sec.gov/exch/2022" xmlns:attributeFormDefault="unqualified" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:srt="http://fasb.org/srt/2022" xmlns:dtr="http://www.xbrl.org/2009/dtr" xmlns:cef="http://xbrl.sec.gov/cef/2022" xmlns:xbrldi="http://xbrl.org/2006/xbrldi">
<xsd:annotation>
<xsd:appinfo>
<link:roleType roleURI="http://www.Cryoport.com/role/StatementCondensedConsolidatedBalanceSheets" id="StatementCondensedConsolidatedBalanceSheets">
<link:definition> 00100 - Statement - Condensed Consolidated Balance Sheets </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/StatementCondensedConsolidatedStatementsOfOperations" id="StatementCondensedConsolidatedStatementsOfOperations">
<link:definition> 00200 - Statement - Condensed Consolidated Statements of Operations </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/StatementCondensedConsolidatedStatementsOfComprehensiveLoss" id="StatementCondensedConsolidatedStatementsOfComprehensiveLoss">
<link:definition> 00300 - Statement - Condensed Consolidated Statements of Comprehensive Loss </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/StatementCondensedConsolidatedStatementsOfCashFlows" id="StatementCondensedConsolidatedStatementsOfCashFlows">
<link:definition> 00500 - Statement - Condensed Consolidated Statements of Cash Flows </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureCashCashEquivalentsAndShortTermInvestmentsEquityInvestmentsDetailss" id="DisclosureCashCashEquivalentsAndShortTermInvestmentsEquityInvestmentsDetailss">
<link:definition> 40404 - Disclosure - Cash, Cash Equivalents and Short-Term Investments - Equity Investments (Details </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureCashCashEquivalentsAndShortTermInvestmentsDetails" id="DisclosureCashCashEquivalentsAndShortTermInvestmentsDetails">
<link:definition> 40501 - Disclosure - Cash, Cash Equivalents and Short-Term Investments (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureCashCashEquivalentsAndShortTermInvestmentsContractualMaturitiesDetails" id="DisclosureCashCashEquivalentsAndShortTermInvestmentsContractualMaturitiesDetails">
<link:definition> 40503 - Disclosure - Cash, Cash Equivalents and Short-Term Investments - Contractual Maturities (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureInventoryDetails" id="DisclosureInventoryDetails">
<link:definition> 40701 - Disclosure - Inventory (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureGoodwillAndIntangibleAssetsExpectedFutureAmortizationDetailss" id="DisclosureGoodwillAndIntangibleAssetsExpectedFutureAmortizationDetailss">
<link:definition> 40803 - Disclosure - Goodwill and Intangible Assets - Expected future amortization (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureConvertibleSeniorNotesComponentsOfConvertibleNotesPayableDetails" id="DisclosureConvertibleSeniorNotesComponentsOfConvertibleNotesPayableDetails">
<link:definition> 40901 - Disclosure - Convertible Senior Notes - Components of Convertible notes payable (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureConvertibleSeniorNotesInterestExpensesIncurredOnConvertibleNotesPayableDetails" id="DisclosureConvertibleSeniorNotesInterestExpensesIncurredOnConvertibleNotesPayableDetails">
<link:definition> 40902 - Disclosure - Convertible Senior Notes - Interest expenses incurred on Convertible notes payable (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureNotesPayableInterestExpenseDetails" id="DisclosureNotesPayableInterestExpenseDetails">
<link:definition> 41002 - Disclosure - Notes Payable - Interest expense (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureNotesPayableFutureNotePaymentsDetails" id="DisclosureNotesPayableFutureNotePaymentsDetails">
<link:definition> 41005 - Disclosure - Notes Payable - Future note payments (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureLeasesComponentsOfLeaseCostDetails" id="DisclosureLeasesComponentsOfLeaseCostDetails">
<link:definition> 41101 - Disclosure - Leases - Components Of Lease Cost (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureLeasesFuturePaymentsUnderNonCancellableLeasesDetails" id="DisclosureLeasesFuturePaymentsUnderNonCancellableLeasesDetails">
<link:definition> 41103 - Disclosure - Leases - Future Payments Under Non-Cancellable Leases (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureLeasesFuturePaymentsUnderNonCancellableLeasesCal2Details" id="DisclosureLeasesFuturePaymentsUnderNonCancellableLeasesCal2Details">
<link:definition> 41203 - Disclosure - Leases - Future Payments Under Non-Cancellable Leases cal2 (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/StatementCondensedConsolidatedBalanceSheetsParenthetical" id="StatementCondensedConsolidatedBalanceSheetsParenthetical">
<link:definition> 00105 - Statement - Condensed Consolidated Balance Sheets (Parenthetical) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/StatementCondensedConsolidatedStatementsOfStockholdersEquity" id="StatementCondensedConsolidatedStatementsOfStockholdersEquity">
<link:definition> 00400 - Statement - Condensed Consolidated Statements of Stockholders' Equity </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/StatementCondensedConsolidatedStatementsOfStockholdersEquityParenthetical" id="StatementCondensedConsolidatedStatementsOfStockholdersEquityParenthetical">
<link:definition> 00405 - Statement - Condensed Consolidated Statements of Stockholders' Equity (Parenthetical) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/StatementCondensedConsolidatedStatementsOfCashFlowsParenthetical" id="StatementCondensedConsolidatedStatementsOfCashFlowsParenthetical">
<link:definition> 00505 - Statement - Condensed Consolidated Statements of Cash Flows (Parenthetical) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureSummaryOfSignificantAccountingPoliciesPolicies" id="DisclosureSummaryOfSignificantAccountingPoliciesPolicies">
<link:definition> 20301 - Disclosure - Summary of Significant Accounting Policies (Policies) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureStockBasedCompensationTables" id="DisclosureStockBasedCompensationTables">
<link:definition> 31403 - Disclosure - Stock-Based Compensation (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureSummaryOfSignificantAccountingPoliciesDisaggregatesOurRevenuesByMajorSourceDetails" id="DisclosureSummaryOfSignificantAccountingPoliciesDisaggregatesOurRevenuesByMajorSourceDetails">
<link:definition> 40301 - Disclosure - Summary of Significant Accounting Policies - Disaggregates Our Revenues by Major Source (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureSummaryOfSignificantAccountingPoliciesDisaggregationOurGeographicalRevenuesByOriginDetails" id="DisclosureSummaryOfSignificantAccountingPoliciesDisaggregationOurGeographicalRevenuesByOriginDetails">
<link:definition> 40302 - Disclosure - Summary of Significant Accounting Policies - Disaggregation Our Geographical Revenues by Origin (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureSummaryOfSignificantAccountingPoliciesEarningsPerShareDetails" id="DisclosureSummaryOfSignificantAccountingPoliciesEarningsPerShareDetails">
<link:definition> 40303 - Disclosure - Summary of Significant Accounting Policies - Earnings Per Share (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureSummaryOfSignificantAccountingPoliciesAntidilutiveSharesDetails" id="DisclosureSummaryOfSignificantAccountingPoliciesAntidilutiveSharesDetails">
<link:definition> 40304 - Disclosure - Summary of Significant Accounting Policies - Antidilutive Shares (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureSummaryOfSignificantAccountingPoliciesAdditionalInformationDetails" id="DisclosureSummaryOfSignificantAccountingPoliciesAdditionalInformationDetails">
<link:definition> 40305 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureAcquisitionAdditionalInformationDetails" id="DisclosureAcquisitionAdditionalInformationDetails">
<link:definition> 40401 - Disclosure - Acquisition - Additional Information (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureCashCashEquivalentsAndShortTermInvestmentsAvailableForSaleInvestmentsDetails" id="DisclosureCashCashEquivalentsAndShortTermInvestmentsAvailableForSaleInvestmentsDetails">
<link:definition> 40502 - Disclosure - Cash, Cash Equivalents and Short-Term Investments - Available-for-sale Investments (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureCashCashEquivalentsAndShortTermInvestmentsEquityInvestmentsDetails" id="DisclosureCashCashEquivalentsAndShortTermInvestmentsEquityInvestmentsDetails">
<link:definition> 40504 - Disclosure - Cash, Cash Equivalents and Short-Term Investments - Equity Investments (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureCashCashEquivalentsAndShortTermInvestmentsAdditionalInformationDetails" id="DisclosureCashCashEquivalentsAndShortTermInvestmentsAdditionalInformationDetails">
<link:definition> 40505 - Disclosure - Cash, Cash Equivalents and Short-Term Investments - Additional Information (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureFairValueMeasurementsDetails" id="DisclosureFairValueMeasurementsDetails">
<link:definition> 40601 - Disclosure - Fair Value Measurements (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureFairValueMeasurementsEstimatedFairValuesAndCarryingValuesDetails" id="DisclosureFairValueMeasurementsEstimatedFairValuesAndCarryingValuesDetails">
<link:definition> 40603 - Disclosure - Fair Value Measurements - Estimated fair values and the carrying values (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureGoodwillAndIntangibleAssetsScheduleOfGoodwillDetails" id="DisclosureGoodwillAndIntangibleAssetsScheduleOfGoodwillDetails">
<link:definition> 40801 - Disclosure - Goodwill and Intangible Assets - Schedule of goodwill (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureGoodwillAndIntangibleAssetsIntangibleAssetsDetails" id="DisclosureGoodwillAndIntangibleAssetsIntangibleAssetsDetails">
<link:definition> 40802 - Disclosure - Goodwill and Intangible Assets - Intangible Assets (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureConvertibleSeniorNotesAdditionalInformationDetails" id="DisclosureConvertibleSeniorNotesAdditionalInformationDetails">
<link:definition> 40903 - Disclosure - Convertible Senior Notes - Additional information (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureNotesPayableDetails" id="DisclosureNotesPayableDetails">
<link:definition> 41001 - Disclosure - Notes Payable (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureNotePayableCryopdpNoteDetails" id="DisclosureNotePayableCryopdpNoteDetails">
<link:definition> 41003 - Disclosure - Note Payable - CRYOPDP Note (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureNotesPayableCellCoNotesDetails" id="DisclosureNotesPayableCellCoNotesDetails">
<link:definition> 41004 - Disclosure - Notes Payable - Cell&Co Notes (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureLeasesSupplementalCashFlowsInformationDetails" id="DisclosureLeasesSupplementalCashFlowsInformationDetails">
<link:definition> 41102 - Disclosure - Leases - Supplemental Cash Flows Information (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureLeasesAdditionalInformationDetails" id="DisclosureLeasesAdditionalInformationDetails">
<link:definition> 41104 - Disclosure - Leases - Additional Information (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureCommitmentsAndContingenciesDetails" id="DisclosureCommitmentsAndContingenciesDetails">
<link:definition> 41201 - Disclosure - Commitments and Contingencies (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureStockholdersEquityCommonStockReservedForFutureIssuanceDetails" id="DisclosureStockholdersEquityCommonStockReservedForFutureIssuanceDetails">
<link:definition> 41301 - Disclosure - Stockholders' Equity - Common Stock Reserved for Future Issuance (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureStockholdersEquityNovember2021RegisteredDirectPlacementAndStockPurchaseAgreementsDetails" id="DisclosureStockholdersEquityNovember2021RegisteredDirectPlacementAndStockPurchaseAgreementsDetails">
<link:definition> 41303 - Disclosure - Stockholders' Equity - November 2021 Registered Direct Placement and Stock Purchase Agreements (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureStockholdersEquityAdditionalInformationDetails" id="DisclosureStockholdersEquityAdditionalInformationDetails">
<link:definition> 41304 - Disclosure - Stockholders' Equity - Additional Information (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureStockBasedCompensationAssumptionsUsedToEstimateFairValueOfStockOptionsDetails" id="DisclosureStockBasedCompensationAssumptionsUsedToEstimateFairValueOfStockOptionsDetails">
<link:definition> 41401 - Disclosure - Stock-Based Compensation - Assumptions Used to Estimate Fair Value of Stock Options (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureStockBasedCompensationStockBasedCompensationExpenseDetails" id="DisclosureStockBasedCompensationStockBasedCompensationExpenseDetails">
<link:definition> 41402 - Disclosure - Stock-Based Compensation - Stock-based Compensation Expense (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureStockBasedCompensationStockOptionActivityDetails" id="DisclosureStockBasedCompensationStockOptionActivityDetails">
<link:definition> 41403 - Disclosure - Stock-Based Compensation - Stock Option Activity (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureStockBasedCompensationRestrictedStockUnitDetails" id="DisclosureStockBasedCompensationRestrictedStockUnitDetails">
<link:definition> 41404 - Disclosure - Stock-Based Compensation - Restricted stock unit (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureStockBasedCompensationAdditionalInformationDetails" id="DisclosureStockBasedCompensationAdditionalInformationDetails">
<link:definition> 41405 - Disclosure - Stock-Based Compensation - Additional Information (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureSubsequentEventsDetails" id="DisclosureSubsequentEventsDetails">
<link:definition> 41501 - Disclosure - Subsequent Events (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DocumentDocumentAndEntityInformation" id="DocumentDocumentAndEntityInformation">
<link:definition> 00090 - Document - Document and Entity Information </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureManagementSRepresentationAndBasisOfPresentation" id="DisclosureManagementSRepresentationAndBasisOfPresentation">
<link:definition> 10101 - Disclosure - Management's Representation and Basis of Presentation </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureNatureOfBusiness" id="DisclosureNatureOfBusiness">
<link:definition> 10201 - Disclosure - Nature of the Business </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureSummaryOfSignificantAccountingPolicies" id="DisclosureSummaryOfSignificantAccountingPolicies">
<link:definition> 10301 - Disclosure - Summary of Significant Accounting Policies </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureAcquisitions" id="DisclosureAcquisitions">
<link:definition> 10401 - Disclosure - Acquisitions </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureCashCashEquivalentsAndShortTermInvestments" id="DisclosureCashCashEquivalentsAndShortTermInvestments">
<link:definition> 10501 - Disclosure - Cash, Cash Equivalents and Short-Term Investments </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureFairValueMeasurements" id="DisclosureFairValueMeasurements">
<link:definition> 10601 - Disclosure - Fair Value Measurements </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureInventory" id="DisclosureInventory">
<link:definition> 10701 - Disclosure - Inventory </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureGoodwillAndIntangibleAssets" id="DisclosureGoodwillAndIntangibleAssets">
<link:definition> 10801 - Disclosure - Goodwill and Intangible Assets </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureConvertibleSeniorNotes" id="DisclosureConvertibleSeniorNotes">
<link:definition> 10901 - Disclosure - Convertible Senior Notes </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureNotePayable" id="DisclosureNotePayable">
<link:definition> 11001 - Disclosure - Note Payable </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureLeases" id="DisclosureLeases">
<link:definition> 11101 - Disclosure - Leases </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureCommitmentsAndContingencies" id="DisclosureCommitmentsAndContingencies">
<link:definition> 11201 - Disclosure - Commitments and Contingencies </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureStockholdersEquity" id="DisclosureStockholdersEquity">
<link:definition> 11301 - Disclosure - Stockholders' Equity </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureStockBasedCompensation" id="DisclosureStockBasedCompensation">
<link:definition> 11401 - Disclosure - Stock-Based Compensation </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureSubsequentEvents" id="DisclosureSubsequentEvents">
<link:definition> 11501 - Disclosure - Subsequent Events </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureSummaryOfSignificantAccountingPoliciesTables" id="DisclosureSummaryOfSignificantAccountingPoliciesTables">
<link:definition> 30303 - Disclosure - Summary of Significant Accounting Policies (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureCashCashEquivalentsAndShortTermInvestmentsTables" id="DisclosureCashCashEquivalentsAndShortTermInvestmentsTables">
<link:definition> 30503 - Disclosure - Cash, Cash Equivalents and Short-Term Investments (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureFairValueMeasurementsTables" id="DisclosureFairValueMeasurementsTables">
<link:definition> 30603 - Disclosure - Fair Value Measurements (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureInventoryTables" id="DisclosureInventoryTables">
<link:definition> 30703 - Disclosure - Inventory (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureGoodwillAndIntangibleAssetsTables" id="DisclosureGoodwillAndIntangibleAssetsTables">
<link:definition> 30803 - Disclosure - Goodwill and Intangible Assets (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureConvertibleSeniorNotesTables" id="DisclosureConvertibleSeniorNotesTables">
<link:definition> 30903 - Disclosure - Convertible Senior Notes (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureNotesPayableTables" id="DisclosureNotesPayableTables">
<link:definition> 31003 - Disclosure - Notes Payable (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureLeasesTables" id="DisclosureLeasesTables">
<link:definition> 31103 - Disclosure - Leases (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureStockholdersEquityTables" id="DisclosureStockholdersEquityTables">
<link:definition> 31303 - Disclosure - Stockholders' Equity (Tables) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureFairValueMeasurementsAdditionalInformationDetails" id="DisclosureFairValueMeasurementsAdditionalInformationDetails">
<link:definition> 40602 - Disclosure - Fair Value Measurements - Additional Information (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureGoodwillAndIntangibleAssetsExpectedFutureAmortizationDetails" id="DisclosureGoodwillAndIntangibleAssetsExpectedFutureAmortizationDetails">
<link:definition> 40803 - Disclosure - Goodwill and Intangible Assets - Expected Future Amortization (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureGoodwillAndIntangibleAssetsAdditionalInformationDetails" id="DisclosureGoodwillAndIntangibleAssetsAdditionalInformationDetails">
<link:definition> 40804 - Disclosure - Goodwill and Intangible Assets - Additional Information (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureStockholdersEquityRepurchaseProgramDetails" id="DisclosureStockholdersEquityRepurchaseProgramDetails">
<link:definition> 41302 - Disclosure - Stockholders' Equity - Repurchase Program (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:linkbaseRef xlink:type="simple" xlink:href="cyrx-20220630_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase"/>
<link:linkbaseRef xlink:type="simple" xlink:href="cyrx-20220630_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase"/>
<link:linkbaseRef xlink:type="simple" xlink:href="cyrx-20220630_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase"/>
<link:linkbaseRef xlink:type="simple" xlink:href="cyrx-20220630_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase"/>
<link:roleType roleURI="http://www.Cryoport.com/role/DisclosureStandardAndCustomAxisDomainDefaults" id="DisclosureStandardAndCustomAxisDomainDefaults">
<link:definition> 99900 - Disclosure - Standard And Custom Axis Domain Defaults </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
</xsd:appinfo>
</xsd:annotation>
<xsd:import namespace="http://xbrl.sec.gov/dei/2022" schemaLocation="https://xbrl.sec.gov/dei/2022/dei-2022.xsd"/>
<xsd:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
<xsd:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd"/>
<xsd:import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd"/>
<xsd:import namespace="http://www.xbrl.org/2009/role/net" schemaLocation="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd"/>
<xsd:import namespace="http://www.xbrl.org/dtr/type/2020-01-21" schemaLocation="https://www.xbrl.org/dtr/type/2020-01-21/types.xsd"/>
<xsd:import namespace="http://fasb.org/us-roles/2022" schemaLocation="https://xbrl.fasb.org/us-gaap/2022/elts/us-roles-2022.xsd"/>
<xsd:import namespace="http://fasb.org/us-gaap/2022" schemaLocation="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd"/>
<xsd:import namespace="http://fasb.org/srt/2022" schemaLocation="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd"/>
<xsd:element name="ClassBConvertiblePreferredStockMember" id="cyrx_ClassBConvertiblePreferredStockMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="StockIssuedDuringPeriodValueStockOptionsAndWarrantsExercised" id="cyrx_StockIssuedDuringPeriodValueStockOptionsAndWarrantsExercised" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element name="StockIssuedDuringPeriodSharesStockOptionsAndWarrantsExercised" id="cyrx_StockIssuedDuringPeriodSharesStockOptionsAndWarrantsExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="OfferingCostAxis" id="cyrx_OfferingCostAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="OfferingCostDomain" id="cyrx_OfferingCostDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="RightOfUseAssetObtainedInExchangeForOperatingLeasesLiability" id="cyrx_RightOfUseAssetObtainedInExchangeForOperatingLeasesLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element name="RepaymentOfFinanceLeaseLiabilities" id="cyrx_RepaymentOfFinanceLeaseLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element name="LesseeOperatingAndFinanceLeasesTextBlock" id="cyrx_LesseeOperatingAndFinanceLeasesTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="ScheduleOfLeaseSupplementalCashFlowAndOtherDisclosuresTableTextBlock" id="cyrx_ScheduleOfLeaseSupplementalCashFlowAndOtherDisclosuresTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="ScheduleOfCommonStockReservedForFutureIssuancesTableTextBlock" id="cyrx_ScheduleOfCommonStockReservedForFutureIssuancesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="RevenueRecognitionTable" id="cyrx_RevenueRecognitionTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="BiopharmaceuticalMember" id="cyrx_BiopharmaceuticalMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="ReproductiveMedicineMember" id="cyrx_ReproductiveMedicineMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="AnimalHealthMember" id="cyrx_AnimalHealthMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="RevenueRecognitionLineItems" id="cyrx_RevenueRecognitionLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="ScheduleOfSignificantAccountingPoliciesTable" id="cyrx_ScheduleOfSignificantAccountingPoliciesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="ForeignCustomersMember" id="cyrx_ForeignCustomersMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="SignificantAccountingPoliciesAdditionalInformationLineItems" id="cyrx_SignificantAccountingPoliciesAdditionalInformationLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="MaturityPeriodOfHighlyLiquidInvestments" id="cyrx_MaturityPeriodOfHighlyLiquidInvestments" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="InstallmentsAxis" id="cyrx_InstallmentsAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="InstallmentsDomain" id="cyrx_InstallmentsDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="CashPaidForAmountsIncludedInMeasurementOfLeaseLiabilitiesAbstract" id="cyrx_CashPaidForAmountsIncludedInMeasurementOfLeaseLiabilitiesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="RightofuseAssetsObtainedInExchangeForLeaseObligationsAbstract" id="cyrx_RightofuseAssetsObtainedInExchangeForLeaseObligationsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="WeightedAverageRemainingLeaseTermAbstract" id="cyrx_WeightedAverageRemainingLeaseTermAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="WeightedAverageDiscountRateAbstract" id="cyrx_WeightedAverageDiscountRateAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="LeaseWeightedAverageRemainingLeaseTerm1" id="cyrx_LeaseWeightedAverageRemainingLeaseTerm1" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="LesseeOptionToExtend" id="cyrx_LesseeOptionToExtend" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="ScheduleOfStockholdersEquityTable" id="cyrx_ScheduleOfStockholdersEquityTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="InvestorsAxis" id="cyrx_InvestorsAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="InvestorsDomain" id="cyrx_InvestorsDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="ServicesAxis" id="cyrx_ServicesAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="ServicesDomain" id="cyrx_ServicesDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" id="cyrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="EngineeringAndDevelopmentMember" id="cyrx_EngineeringAndDevelopmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" id="cyrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="Plan2018Member" id="cyrx_Plan2018Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="NumberOfMembers" id="cyrx_NumberOfMembers" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="NatureOfBusinessAbstract" id="cyrx_NatureOfBusinessAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="EquipmentAndFurnitureMember" id="cyrx_EquipmentAndFurnitureMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="PatentsAndTrademarksMember" id="cyrx_PatentsAndTrademarksMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="ReclassificationOfRealizedGainOnAvailableForSaleDebtSecuritiesToEarnings" id="cyrx_ReclassificationOfRealizedGainOnAvailableForSaleDebtSecuritiesToEarnings" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element name="PublicOfferingMember" id="cyrx_PublicOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="NonCashNetUnrealizedGainLossOnAvailableForSaleSecurities" id="cyrx_NonCashNetUnrealizedGainLossOnAvailableForSaleSecurities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element name="RealizedLossOnInvestmentsInEquitySecurities" id="cyrx_RealizedLossOnInvestmentsInEquitySecurities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element name="NumberOfCustomers" id="cyrx_NumberOfCustomers" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="FutureAmortizationOfFiniteLivedIntangibleAssets" id="cyrx_FutureAmortizationOfFiniteLivedIntangibleAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element name="ScheduleOfInterestExpensesOnConvertibleNotesPayableTableTextBlock" id="cyrx_ScheduleOfInterestExpensesOnConvertibleNotesPayableTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="ScenarioOneMember" id="cyrx_ScenarioOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="ScenarioTwoMember" id="cyrx_ScenarioTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="ThirdPartyOfferingRelatedCosts" id="cyrx_ThirdPartyOfferingRelatedCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element name="DebtInstrumentRedemptionThresholdTradingDays" id="cyrx_DebtInstrumentRedemptionThresholdTradingDays" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="DebtInstrumentRedemptionThresholdConsecutiveTradingDays" id="cyrx_DebtInstrumentRedemptionThresholdConsecutiveTradingDays" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="DebtInstrumentRegistrationDefaultAdditionalInterestRate" id="cyrx_DebtInstrumentRegistrationDefaultAdditionalInterestRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="DebtInstrumentRegistrationDefaultThresholdMaximumCombinedInterestRate" id="cyrx_DebtInstrumentRegistrationDefaultThresholdMaximumCombinedInterestRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="DebtInstrumentRegistrationDefaultCashPaymentToEachNoteholderPercentage" id="cyrx_DebtInstrumentRegistrationDefaultCashPaymentToEachNoteholderPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="ConvertibleSeniorNotesMember" id="cyrx_ConvertibleSeniorNotesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour" id="cyrx_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant"/>
<xsd:element name="InterestAmountOnAccountsPayableAndAccruedLiabilities" id="cyrx_InterestAmountOnAccountsPayableAndAccruedLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element name="ClassCConvertiblePreferredStockMember" id="cyrx_ClassCConvertiblePreferredStockMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="MveCryobiologicalStorageBusinessMember" id="cyrx_MveCryobiologicalStorageBusinessMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="CryopdpMember" id="cyrx_CryopdpMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="PreferredStockRedemptionPeriodAxis" id="cyrx_PreferredStockRedemptionPeriodAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="PreferredStockRedemptionPeriodDomain" id="cyrx_PreferredStockRedemptionPeriodDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="PreferredStockRedemptionPeriodOneMember" id="cyrx_PreferredStockRedemptionPeriodOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="PreferredStockRedemptionPeriodTwoMember" id="cyrx_PreferredStockRedemptionPeriodTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="PreferredStockRedemptionPeriodThreeMember" id="cyrx_PreferredStockRedemptionPeriodThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="ReimbursementOfTransactionalExpenses" id="cyrx_ReimbursementOfTransactionalExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element name="NetProceedsFromIssuanceOfPrivatePlacement" id="cyrx_NetProceedsFromIssuanceOfPrivatePlacement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element name="PreferredStockConvertibleConversionPricePerShare" id="cyrx_PreferredStockConvertibleConversionPricePerShare" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="PreferredStockConvertibleConversionRate" id="cyrx_PreferredStockConvertibleConversionRate" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="PreferredStockConvertibleThresholdTradingDays" id="cyrx_PreferredStockConvertibleThresholdTradingDays" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="PreferredStockConvertibleThresholdConsecutiveTradingDays" id="cyrx_PreferredStockConvertibleThresholdConsecutiveTradingDays" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="PreferredStockConvertibleStockPriceTriggerPercentage" id="cyrx_PreferredStockConvertibleStockPriceTriggerPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="DeemedDividend" id="cyrx_DeemedDividend" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element name="PreferredStockSharesToBeRedeemed" id="cyrx_PreferredStockSharesToBeRedeemed" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="PreferredStockRedemptionPricePercentage" id="cyrx_PreferredStockRedemptionPricePercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="PreferredStockIfNotRepurchasedDividendRatePercentage" id="cyrx_PreferredStockIfNotRepurchasedDividendRatePercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="NumberOfBoardMemberWhoCanBeElectedByPreferredStockHolders" id="cyrx_NumberOfBoardMemberWhoCanBeElectedByPreferredStockHolders" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="PreferredStockOwnershipPercentageToExerciseRightToNominateBoard" id="cyrx_PreferredStockOwnershipPercentageToExerciseRightToNominateBoard" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="PreferredClassCMember" id="cyrx_PreferredClassCMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="FreezerMember" id="cyrx_FreezerMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="TruckAndAutoMember" id="cyrx_TruckAndAutoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="NumberOfInstallments" id="cyrx_NumberOfInstallments" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="NotesPayableTextBlock" id="cyrx_NotesPayableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="AgentNetworkMember" id="cyrx_AgentNetworkMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="PaidInKindDividendOnSeriesCConvertiblePreferredStockValue" id="cyrx_PaidInKindDividendOnSeriesCConvertiblePreferredStockValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element name="PaidInKindDividendOnSeriesCConvertiblePreferredStocksValue" id="cyrx_PaidInKindDividendOnSeriesCConvertiblePreferredStocksValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element name="BusinessCombinationsAcquisitionCostsPolicyPolicyTextBlock" id="cyrx_BusinessCombinationsAcquisitionCostsPolicyPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="AdjustmentsToAdditionalPaidInCapitalPaidInKindDividends" id="cyrx_AdjustmentsToAdditionalPaidInCapitalPaidInKindDividends" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element name="StatutoryCreditUsageLimitForResearchAndDevelopmentForTaxRelief" id="cyrx_StatutoryCreditUsageLimitForResearchAndDevelopmentForTaxRelief" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element name="TaxExaminationPeriodForForeignSubsidiaries" id="cyrx_TaxExaminationPeriodForForeignSubsidiaries" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="AdjustmentsToAdditionalPaidInCapitalConversionCosts" id="cyrx_AdjustmentsToAdditionalPaidInCapitalConversionCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element name="CostOfSeriesCPreferredStockConversionIncludedInAdditionalPaidInCapitalAndAccountsPayableAndAccruedLiabilities" id="cyrx_CostOfSeriesCPreferredStockConversionIncludedInAdditionalPaidInCapitalAndAccountsPayableAndAccruedLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element name="GoodwillAdjustmentIncludedInDeferredTaxLiability" id="cyrx_GoodwillAdjustmentIncludedInDeferredTaxLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element name="GoodwillAdjustmentIncludedInFixedAssets" id="cyrx_GoodwillAdjustmentIncludedInFixedAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element name="NoteValuationAdjustmentIncludedInNotePayableAndGoodwill" id="cyrx_NoteValuationAdjustmentIncludedInNotePayableAndGoodwill" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsIssuedInPeriod" id="cyrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsIssuedInPeriod" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="PreferredStockConvertibleConversionCost" id="cyrx_PreferredStockConvertibleConversionCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element name="AcquireeWorkingCapitalSettlementIncludedInGoodwillAndAccountsPayable" id="cyrx_AcquireeWorkingCapitalSettlementIncludedInGoodwillAndAccountsPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element name="CriticalTransportSolutionsAustraliaAndFairgateMember" id="cyrx_CriticalTransportSolutionsAustraliaAndFairgateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="BusinessCombinationContingentConsiderationLiabilityFairValueDisclosure" id="cyrx_BusinessCombinationContingentConsiderationLiabilityFairValueDisclosure" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant"/>
<xsd:element name="FirstInstallmentRepayableNoLaterThanDecember312021Member" id="cyrx_FirstInstallmentRepayableNoLaterThanDecember312021Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="SecondInstallmentRepayableNoLaterThanDecember312022Member" id="cyrx_SecondInstallmentRepayableNoLaterThanDecember312022Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorizedButUnissued" id="cyrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorizedButUnissued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="ThresholdUsedForCalculatingConcentrationOfRisk" id="cyrx_ThresholdUsedForCalculatingConcentrationOfRisk" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="CustomerMember" id="cyrx_CustomerMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="CostOfServicesRevenuesPolicyTextBlock" id="cyrx_CostOfServicesRevenuesPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="CostOfProductRevenuesPolicyTextBlock" id="cyrx_CostOfProductRevenuesPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="BusinessCombinationPriorPeriodAdjustmentDeferredTax" id="cyrx_BusinessCombinationPriorPeriodAdjustmentDeferredTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element name="SeniorNotes2025Member" id="cyrx_SeniorNotes2025Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="SeniorNotes2026Member" id="cyrx_SeniorNotes2026Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="CashRepurchasePrise" id="cyrx_CashRepurchasePrise" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element name="LossOnExtinguishmentOfDebt" id="cyrx_LossOnExtinguishmentOfDebt" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element name="TotalRemainingPrincipalAmountOutstanding" id="cyrx_TotalRemainingPrincipalAmountOutstanding" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element name="ExclusiveRightOfNoteholdersMaximumPercentageOfSpecialInterestOnPrincipalAmount" id="cyrx_ExclusiveRightOfNoteholdersMaximumPercentageOfSpecialInterestOnPrincipalAmount" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="ExclusiveRightOfNoteholdersMaximumNumberOfDaysToReceiveSpecialInterestOnSeniorNotes" id="cyrx_ExclusiveRightOfNoteholdersMaximumNumberOfDaysToReceiveSpecialInterestOnSeniorNotes" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="MveBiologicalSolutionsMember" id="cyrx_MveBiologicalSolutionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="DebtInstrumentConvertibleConversionPrice" id="cyrx_DebtInstrumentConvertibleConversionPrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="instant"/>
<xsd:element name="DebtInstrumentConvertibleThresholdMaximumConversionRatio" id="cyrx_DebtInstrumentConvertibleThresholdMaximumConversionRatio" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="AccumulatedOtherComprehensiveIncomeLoss" id="cyrx_AccumulatedOtherComprehensiveIncomeLoss" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="instant"/>
<xsd:element name="ConcurrentPlacementMember" id="cyrx_ConcurrentPlacementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="DebtInstrumentRedemptionPrincipalAmountRedeemed" id="cyrx_DebtInstrumentRedemptionPrincipalAmountRedeemed" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration"/>
<xsd:element name="NetProceedsAfterDeductingBankerFeesToBeUsedForGeneralCorporatePurposes" id="cyrx_NetProceedsAfterDeductingBankerFeesToBeUsedForGeneralCorporatePurposes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration"/>
<xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardWeightedaverageFairvalueperShares" id="cyrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardWeightedaverageFairvalueperShares" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="CellCoBioservicesMember" id="cyrx_CellCoBioservicesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration"/>
<xsd:element name="PaymentsForProceedsFromInsuranceProceedsForLossFromFixedAssets" id="cyrx_PaymentsForProceedsFromInsuranceProceedsForLossFromFixedAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit"/>
<xsd:element name="CurrentPortionOfOperatingLeaseLiability" id="cyrx_CurrentPortionOfOperatingLeaseLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit"/>
<xsd:element name="NonCurrentPortionOfOperatingLeaseLiability" id="cyrx_NonCurrentPortionOfOperatingLeaseLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit"/>
<xsd:element name="RevenuePracticalExpedientRemainingPerformanceObligation." id="cyrx_RevenuePracticalExpedientRemainingPerformanceObligation." type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false"/>
<xsd:element name="PaymentsToAcquireCellAndCo" id="cyrx_PaymentsToAcquireCellAndCo" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit"/>
<xsd:element name="PaymentsToAcquireCtsaAndFairGate" id="cyrx_PaymentsToAcquireCtsaAndFairGate" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit"/>
<xsd:element name="ScheduleOfInterestExpenseOnNotesPayableTableTextBlock" id="cyrx_ScheduleOfInterestExpenseOnNotesPayableTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false"/>
<xsd:element name="NotesPayableMember" id="cyrx_NotesPayableMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true"/>
<xsd:element name="NotesPayableMaturingOnJuly2027Member" id="cyrx_NotesPayableMaturingOnJuly2027Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true"/>
<xsd:element name="NotesPayableMaturingOnJuly2030Member" id="cyrx_NotesPayableMaturingOnJuly2030Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true"/>
<xsd:element name="PolarExpressMadridSpainMember" id="cyrx_PolarExpressMadridSpainMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true"/>
<xsd:element name="CellMattersBasedInLiegeBelgiumMember" id="cyrx_CellMattersBasedInLiegeBelgiumMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true"/>
<xsd:element name="NonCashActivityOfCommonStockIssuedForCellCoAcquisition" id="cyrx_NonCashActivityOfCommonStockIssuedForCellCoAcquisition" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit"/>
<xsd:element name="BusinessCombinationConsiderationUpfrontFees" id="cyrx_BusinessCombinationConsiderationUpfrontFees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit"/>
<xsd:element name="BusinessCombinationAcquisitionEquityInterestSharesIssuable" id="cyrx_BusinessCombinationAcquisitionEquityInterestSharesIssuable" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false"/>
<xsd:element name="ExcessAndObsoleteInventory" id="cyrx_ExcessAndObsoleteInventory" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit"/>
</xsd:schema>

↑Top
Filing Submission 0001410578-22-002045   –   Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)
Copyright © 2024 Fran Finnegan & Company LLC – All Rights Reserved.
About — Privacy — Redactions — Help — Sun., May 5, 1:27:00.1pm ET