| | | | | | | | | | | | | | | | | | | | | |
<?xml version="1.0" encoding="windows-1252"?> |
<xbrl xml:lang="en-US" xmlns="http://www.xbrl.org/2003/instance" xmlns:dei="http://xbrl.sec.gov/dei/2019-01-31" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink"> |
| <link:schemaRef xlink:href="blue-20210420.xsd" xlink:type="simple"/> |
| <context id="i6010e777a5c24091b16eb4556fb40a74_D20210420-20210420"> |
| | <entity> |
| | | <identifier scheme="http://www.sec.gov/CIK"> 0001293971 </identifier> |
| | | </entity> |
| | <period> |
| | | <startDate> 2021-04-20 </startDate> |
| | | <endDate> 2021-04-20 </endDate> |
| | | </period> |
| | </context> |
| <dei:EntityCentralIndexKey contextRef="i6010e777a5c24091b16eb4556fb40a74_D20210420-20210420" id="id3VybDovL2RvY3MudjEvZG9jOmI4YThlMDc5NjE2NTQ2NzA4MjhjZDg0YjljNDYzMGU2L3NlYzpiOGE4ZTA3OTYxNjU0NjcwODI4Y2Q4NGI5YzQ2MzBlNl80L2ZyYWc6NTlkY2FiMWQ4ZmVjNDAzOGI2NjI5OGY3MjUyZWY4MzIvdGFibGU6MzdmMzYxMzAzZWUyNDY2NjkyMzkyYTkxN2JiMGZmYzkvdGFibGVyYW5nZTozN2YzNjEzMDNlZTI0NjY2OTIzOTJhOTE3YmIwZmZjOV8yLTEtMS0xLTA_679c2246-0b23-4e11-b7d5-81a781aeb3f5"> 0001293971 </dei:EntityCentralIndexKey> |
| <dei:AmendmentFlag contextRef="i6010e777a5c24091b16eb4556fb40a74_D20210420-20210420" id="id3VybDovL2RvY3MudjEvZG9jOmI4YThlMDc5NjE2NTQ2NzA4MjhjZDg0YjljNDYzMGU2L3NlYzpiOGE4ZTA3OTYxNjU0NjcwODI4Y2Q4NGI5YzQ2MzBlNl80L2ZyYWc6NTlkY2FiMWQ4ZmVjNDAzOGI2NjI5OGY3MjUyZWY4MzIvdGFibGU6MzdmMzYxMzAzZWUyNDY2NjkyMzkyYTkxN2JiMGZmYzkvdGFibGVyYW5nZTozN2YzNjEzMDNlZTI0NjY2OTIzOTJhOTE3YmIwZmZjOV81LTEtMS0xLTA_20d9705c-35b9-44d8-a276-778ad9feee93"> false </dei:AmendmentFlag> |
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| <dei:DocumentPeriodEndDate contextRef="i6010e777a5c24091b16eb4556fb40a74_D20210420-20210420" id="id3VybDovL2RvY3MudjEvZG9jOmI4YThlMDc5NjE2NTQ2NzA4MjhjZDg0YjljNDYzMGU2L3NlYzpiOGE4ZTA3OTYxNjU0NjcwODI4Y2Q4NGI5YzQ2MzBlNl8xL2ZyYWc6ZTYyYmQwZTdjOGRkNGViNTk1NWMzZTk2NDFiYzVmMGUvdGV4dHJlZ2lvbjplNjJiZDBlN2M4ZGQ0ZWI1OTU1YzNlOTY0MWJjNWYwZV8yNzU_f78b28ed-d451-4b0d-b180-024d154b2eaa"> 2021-04-20 </dei:DocumentPeriodEndDate> |
| <dei:EntityRegistrantName contextRef="i6010e777a5c24091b16eb4556fb40a74_D20210420-20210420" id="id3VybDovL2RvY3MudjEvZG9jOmI4YThlMDc5NjE2NTQ2NzA4MjhjZDg0YjljNDYzMGU2L3NlYzpiOGE4ZTA3OTYxNjU0NjcwODI4Y2Q4NGI5YzQ2MzBlNl8xL2ZyYWc6ZTYyYmQwZTdjOGRkNGViNTk1NWMzZTk2NDFiYzVmMGUvdGV4dHJlZ2lvbjplNjJiZDBlN2M4ZGQ0ZWI1OTU1YzNlOTY0MWJjNWYwZV8zMDU_ecc12aff-4223-4c11-81f2-e5502a30bfcc"> bluebird bio, Inc. </dei:EntityRegistrantName> |
| <dei:EntityIncorporationStateCountryCode contextRef="i6010e777a5c24091b16eb4556fb40a74_D20210420-20210420" id="id3VybDovL2RvY3MudjEvZG9jOmI4YThlMDc5NjE2NTQ2NzA4MjhjZDg0YjljNDYzMGU2L3NlYzpiOGE4ZTA3OTYxNjU0NjcwODI4Y2Q4NGI5YzQ2MzBlNl8xL2ZyYWc6ZTYyYmQwZTdjOGRkNGViNTk1NWMzZTk2NDFiYzVmMGUvdGFibGU6MTlhZTYwNWVlMjVhNDQwZGIzODg5ZDdlZTc0MDAyODcvdGFibGVyYW5nZToxOWFlNjA1ZWUyNWE0NDBkYjM4ODlkN2VlNzQwMDI4N18wLTAtMS0xLTA_1cc85f4b-76ca-49ec-b053-d86f0e0ff2d2"> DE </dei:EntityIncorporationStateCountryCode> |
| <dei:EntityFileNumber contextRef="i6010e777a5c24091b16eb4556fb40a74_D20210420-20210420" id="id3VybDovL2RvY3MudjEvZG9jOmI4YThlMDc5NjE2NTQ2NzA4MjhjZDg0YjljNDYzMGU2L3NlYzpiOGE4ZTA3OTYxNjU0NjcwODI4Y2Q4NGI5YzQ2MzBlNl8xL2ZyYWc6ZTYyYmQwZTdjOGRkNGViNTk1NWMzZTk2NDFiYzVmMGUvdGFibGU6MTlhZTYwNWVlMjVhNDQwZGIzODg5ZDdlZTc0MDAyODcvdGFibGVyYW5nZToxOWFlNjA1ZWUyNWE0NDBkYjM4ODlkN2VlNzQwMDI4N18wLTEtMS0xLTA_cca178c0-6528-4225-acd0-cf6c1bd2af4d"> 001-35966 </dei:EntityFileNumber> |
| <dei:EntityTaxIdentificationNumber contextRef="i6010e777a5c24091b16eb4556fb40a74_D20210420-20210420" id="id3VybDovL2RvY3MudjEvZG9jOmI4YThlMDc5NjE2NTQ2NzA4MjhjZDg0YjljNDYzMGU2L3NlYzpiOGE4ZTA3OTYxNjU0NjcwODI4Y2Q4NGI5YzQ2MzBlNl8xL2ZyYWc6ZTYyYmQwZTdjOGRkNGViNTk1NWMzZTk2NDFiYzVmMGUvdGFibGU6MTlhZTYwNWVlMjVhNDQwZGIzODg5ZDdlZTc0MDAyODcvdGFibGVyYW5nZToxOWFlNjA1ZWUyNWE0NDBkYjM4ODlkN2VlNzQwMDI4N18wLTItMS0xLTA_83de4e8d-67da-4232-abd1-8212030fd780"> 13-3680878 </dei:EntityTaxIdentificationNumber> |
| <dei:EntityAddressAddressLine1 contextRef="i6010e777a5c24091b16eb4556fb40a74_D20210420-20210420" id="id3VybDovL2RvY3MudjEvZG9jOmI4YThlMDc5NjE2NTQ2NzA4MjhjZDg0YjljNDYzMGU2L3NlYzpiOGE4ZTA3OTYxNjU0NjcwODI4Y2Q4NGI5YzQ2MzBlNl8xL2ZyYWc6ZTYyYmQwZTdjOGRkNGViNTk1NWMzZTk2NDFiYzVmMGUvdGFibGU6MTlhZTYwNWVlMjVhNDQwZGIzODg5ZDdlZTc0MDAyODcvdGFibGVyYW5nZToxOWFlNjA1ZWUyNWE0NDBkYjM4ODlkN2VlNzQwMDI4N18zLTAtMS0xLTAvdGV4dHJlZ2lvbjozNTQwMDZiMzhhNjc0YTVlODlkMGI0NTJiM2M1NTliN180_ba86f5cb-4f9e-43a8-97e1-c2064de85b62"> 60 Binney Street </dei:EntityAddressAddressLine1> |
| <dei:EntityAddressCityOrTown contextRef="i6010e777a5c24091b16eb4556fb40a74_D20210420-20210420" id="id3VybDovL2RvY3MudjEvZG9jOmI4YThlMDc5NjE2NTQ2NzA4MjhjZDg0YjljNDYzMGU2L3NlYzpiOGE4ZTA3OTYxNjU0NjcwODI4Y2Q4NGI5YzQ2MzBlNl8xL2ZyYWc6ZTYyYmQwZTdjOGRkNGViNTk1NWMzZTk2NDFiYzVmMGUvdGFibGU6MTlhZTYwNWVlMjVhNDQwZGIzODg5ZDdlZTc0MDAyODcvdGFibGVyYW5nZToxOWFlNjA1ZWUyNWE0NDBkYjM4ODlkN2VlNzQwMDI4N18zLTAtMS0xLTAvdGV4dHJlZ2lvbjozNTQwMDZiMzhhNjc0YTVlODlkMGI0NTJiM2M1NTliN184_a83e1746-a1bc-4f30-bed5-db3e971717c7"> Cambridge </dei:EntityAddressCityOrTown> |
| <dei:EntityAddressStateOrProvince contextRef="i6010e777a5c24091b16eb4556fb40a74_D20210420-20210420" id="id3VybDovL2RvY3MudjEvZG9jOmI4YThlMDc5NjE2NTQ2NzA4MjhjZDg0YjljNDYzMGU2L3NlYzpiOGE4ZTA3OTYxNjU0NjcwODI4Y2Q4NGI5YzQ2MzBlNl8xL2ZyYWc6ZTYyYmQwZTdjOGRkNGViNTk1NWMzZTk2NDFiYzVmMGUvdGFibGU6MTlhZTYwNWVlMjVhNDQwZGIzODg5ZDdlZTc0MDAyODcvdGFibGVyYW5nZToxOWFlNjA1ZWUyNWE0NDBkYjM4ODlkN2VlNzQwMDI4N18zLTAtMS0xLTAvdGV4dHJlZ2lvbjozNTQwMDZiMzhhNjc0YTVlODlkMGI0NTJiM2M1NTliN18xMg_d3e595cb-01d8-4f5c-820f-2bb17d78c65d"> MA </dei:EntityAddressStateOrProvince> |
| <dei:EntityAddressPostalZipCode contextRef="i6010e777a5c24091b16eb4556fb40a74_D20210420-20210420" id="id3VybDovL2RvY3MudjEvZG9jOmI4YThlMDc5NjE2NTQ2NzA4MjhjZDg0YjljNDYzMGU2L3NlYzpiOGE4ZTA3OTYxNjU0NjcwODI4Y2Q4NGI5YzQ2MzBlNl8xL2ZyYWc6ZTYyYmQwZTdjOGRkNGViNTk1NWMzZTk2NDFiYzVmMGUvdGFibGU6MTlhZTYwNWVlMjVhNDQwZGIzODg5ZDdlZTc0MDAyODcvdGFibGVyYW5nZToxOWFlNjA1ZWUyNWE0NDBkYjM4ODlkN2VlNzQwMDI4N18zLTItMS0xLTA_59a5a6af-a846-4046-9514-3fcbbbf7891c"> 02142 </dei:EntityAddressPostalZipCode> |
| <dei:CityAreaCode contextRef="i6010e777a5c24091b16eb4556fb40a74_D20210420-20210420" id="id3VybDovL2RvY3MudjEvZG9jOmI4YThlMDc5NjE2NTQ2NzA4MjhjZDg0YjljNDYzMGU2L3NlYzpiOGE4ZTA3OTYxNjU0NjcwODI4Y2Q4NGI5YzQ2MzBlNl8xL2ZyYWc6ZTYyYmQwZTdjOGRkNGViNTk1NWMzZTk2NDFiYzVmMGUvdGV4dHJlZ2lvbjplNjJiZDBlN2M4ZGQ0ZWI1OTU1YzNlOTY0MWJjNWYwZV80Nzk_6bd49bb9-b6ae-4e1b-ac21-6c25173e9af4"> 339 </dei:CityAreaCode> |
| <dei:LocalPhoneNumber contextRef="i6010e777a5c24091b16eb4556fb40a74_D20210420-20210420" id="id3VybDovL2RvY3MudjEvZG9jOmI4YThlMDc5NjE2NTQ2NzA4MjhjZDg0YjljNDYzMGU2L3NlYzpiOGE4ZTA3OTYxNjU0NjcwODI4Y2Q4NGI5YzQ2MzBlNl8xL2ZyYWc6ZTYyYmQwZTdjOGRkNGViNTk1NWMzZTk2NDFiYzVmMGUvdGV4dHJlZ2lvbjplNjJiZDBlN2M4ZGQ0ZWI1OTU1YzNlOTY0MWJjNWYwZV80ODM_7de4480f-7506-4f74-ad2d-953b923dbb1c"> 499-9300 </dei:LocalPhoneNumber> |
| <dei:WrittenCommunications contextRef="i6010e777a5c24091b16eb4556fb40a74_D20210420-20210420" id="id3VybDovL2RvY3MudjEvZG9jOmI4YThlMDc5NjE2NTQ2NzA4MjhjZDg0YjljNDYzMGU2L3NlYzpiOGE4ZTA3OTYxNjU0NjcwODI4Y2Q4NGI5YzQ2MzBlNl8xL2ZyYWc6ZTYyYmQwZTdjOGRkNGViNTk1NWMzZTk2NDFiYzVmMGUvdGFibGU6ODZkNjFhNGUyZTRjNDdiMTk3ZWNkYjFlYmQwZjQ1YzkvdGFibGVyYW5nZTo4NmQ2MWE0ZTJlNGM0N2IxOTdlY2RiMWViZDBmNDVjOV8wLTAtMS0xLTA_1c500e1b-ee9b-4bfe-8cbc-cd3207cbfc5c"> false </dei:WrittenCommunications> |
| <dei:SolicitingMaterial contextRef="i6010e777a5c24091b16eb4556fb40a74_D20210420-20210420" id="id3VybDovL2RvY3MudjEvZG9jOmI4YThlMDc5NjE2NTQ2NzA4MjhjZDg0YjljNDYzMGU2L3NlYzpiOGE4ZTA3OTYxNjU0NjcwODI4Y2Q4NGI5YzQ2MzBlNl8xL2ZyYWc6ZTYyYmQwZTdjOGRkNGViNTk1NWMzZTk2NDFiYzVmMGUvdGFibGU6ODZkNjFhNGUyZTRjNDdiMTk3ZWNkYjFlYmQwZjQ1YzkvdGFibGVyYW5nZTo4NmQ2MWE0ZTJlNGM0N2IxOTdlY2RiMWViZDBmNDVjOV8xLTAtMS0xLTA_9943ce16-ed82-4a0d-93dc-8a170a8395d4"> false </dei:SolicitingMaterial> |
| <dei:PreCommencementTenderOffer contextRef="i6010e777a5c24091b16eb4556fb40a74_D20210420-20210420" id="id3VybDovL2RvY3MudjEvZG9jOmI4YThlMDc5NjE2NTQ2NzA4MjhjZDg0YjljNDYzMGU2L3NlYzpiOGE4ZTA3OTYxNjU0NjcwODI4Y2Q4NGI5YzQ2MzBlNl8xL2ZyYWc6ZTYyYmQwZTdjOGRkNGViNTk1NWMzZTk2NDFiYzVmMGUvdGFibGU6ODZkNjFhNGUyZTRjNDdiMTk3ZWNkYjFlYmQwZjQ1YzkvdGFibGVyYW5nZTo4NmQ2MWE0ZTJlNGM0N2IxOTdlY2RiMWViZDBmNDVjOV8yLTAtMS0xLTA_0c25c99c-2d68-473f-be14-e448a722eee3"> false </dei:PreCommencementTenderOffer> |
| <dei:PreCommencementIssuerTenderOffer contextRef="i6010e777a5c24091b16eb4556fb40a74_D20210420-20210420" id="id3VybDovL2RvY3MudjEvZG9jOmI4YThlMDc5NjE2NTQ2NzA4MjhjZDg0YjljNDYzMGU2L3NlYzpiOGE4ZTA3OTYxNjU0NjcwODI4Y2Q4NGI5YzQ2MzBlNl8xL2ZyYWc6ZTYyYmQwZTdjOGRkNGViNTk1NWMzZTk2NDFiYzVmMGUvdGFibGU6ODZkNjFhNGUyZTRjNDdiMTk3ZWNkYjFlYmQwZjQ1YzkvdGFibGVyYW5nZTo4NmQ2MWE0ZTJlNGM0N2IxOTdlY2RiMWViZDBmNDVjOV8zLTAtMS0xLTA_b0642b44-af84-46be-9dff-a613af1006ac"> false </dei:PreCommencementIssuerTenderOffer> |
| <dei:Security12bTitle contextRef="i6010e777a5c24091b16eb4556fb40a74_D20210420-20210420" id="id3VybDovL2RvY3MudjEvZG9jOmI4YThlMDc5NjE2NTQ2NzA4MjhjZDg0YjljNDYzMGU2L3NlYzpiOGE4ZTA3OTYxNjU0NjcwODI4Y2Q4NGI5YzQ2MzBlNl8xL2ZyYWc6ZTYyYmQwZTdjOGRkNGViNTk1NWMzZTk2NDFiYzVmMGUvdGFibGU6MjgxMDk5NDc1MzYxNGI4ZWExMTkzZDg4YzA5ZjM1MTQvdGFibGVyYW5nZToyODEwOTk0NzUzNjE0YjhlYTExOTNkODhjMDlmMzUxNF8xLTAtMS0xLTA_0c179549-f862-4db4-9e2b-dba2a1887a9a"> Common Stock, $0.01 par value per share </dei:Security12bTitle> |
| <dei:TradingSymbol contextRef="i6010e777a5c24091b16eb4556fb40a74_D20210420-20210420" id="id3VybDovL2RvY3MudjEvZG9jOmI4YThlMDc5NjE2NTQ2NzA4MjhjZDg0YjljNDYzMGU2L3NlYzpiOGE4ZTA3OTYxNjU0NjcwODI4Y2Q4NGI5YzQ2MzBlNl8xL2ZyYWc6ZTYyYmQwZTdjOGRkNGViNTk1NWMzZTk2NDFiYzVmMGUvdGFibGU6MjgxMDk5NDc1MzYxNGI4ZWExMTkzZDg4YzA5ZjM1MTQvdGFibGVyYW5nZToyODEwOTk0NzUzNjE0YjhlYTExOTNkODhjMDlmMzUxNF8xLTEtMS0xLTA_109c8f3a-e878-4b34-b5bf-c97bb1c2b289"> BLUE </dei:TradingSymbol> |
| <dei:SecurityExchangeName contextRef="i6010e777a5c24091b16eb4556fb40a74_D20210420-20210420" id="id3VybDovL2RvY3MudjEvZG9jOmI4YThlMDc5NjE2NTQ2NzA4MjhjZDg0YjljNDYzMGU2L3NlYzpiOGE4ZTA3OTYxNjU0NjcwODI4Y2Q4NGI5YzQ2MzBlNl8xL2ZyYWc6ZTYyYmQwZTdjOGRkNGViNTk1NWMzZTk2NDFiYzVmMGUvdGFibGU6MjgxMDk5NDc1MzYxNGI4ZWExMTkzZDg4YzA5ZjM1MTQvdGFibGVyYW5nZToyODEwOTk0NzUzNjE0YjhlYTExOTNkODhjMDlmMzUxNF8xLTItMS0xLTA_017afd31-b1c9-4413-b054-d97fc1e866fc"> NASDAQ </dei:SecurityExchangeName> |
| <dei:EntityEmergingGrowthCompany contextRef="i6010e777a5c24091b16eb4556fb40a74_D20210420-20210420" id="id3VybDovL2RvY3MudjEvZG9jOmI4YThlMDc5NjE2NTQ2NzA4MjhjZDg0YjljNDYzMGU2L3NlYzpiOGE4ZTA3OTYxNjU0NjcwODI4Y2Q4NGI5YzQ2MzBlNl8xL2ZyYWc6ZTYyYmQwZTdjOGRkNGViNTk1NWMzZTk2NDFiYzVmMGUvdGV4dHJlZ2lvbjplNjJiZDBlN2M4ZGQ0ZWI1OTU1YzNlOTY0MWJjNWYwZV8xMTYx_5280faef-82cb-4a8c-9cef-612ceb395615"> false </dei:EntityEmergingGrowthCompany> |
| </xbrl> |