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AVROBIO, Inc. – ‘10-K’ for 12/31/18 – ‘EX-101.SCH’

On:  Monday, 3/25/19, at 4:31pm ET   ·   For:  12/31/18   ·   Accession #:  1193125-19-85321   ·   File #:  1-38537

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  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 3/25/19  AVROBIO, Inc.                     10-K       12/31/18   85:7.2M                                   Donnelley … Solutions/FA

Annual Report   —   Form 10-K   —   Sect. 13 / 15(d) – SEA’34
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-K        Annual Report                                       HTML   1.06M 
 2: EX-10.13    Material Contract                                   HTML     84K 
 3: EX-10.14    Material Contract                                   HTML     61K 
 4: EX-10.15    Material Contract                                   HTML     90K 
 5: EX-21.1     Subsidiaries List                                   HTML     24K 
 6: EX-23.1     Consent of Experts or Counsel                       HTML     25K 
 7: EX-31.1     Certification -- §302 - SOA'02                      HTML     30K 
 8: EX-31.2     Certification -- §302 - SOA'02                      HTML     30K 
 9: EX-32.1     Certification -- §906 - SOA'02                      HTML     28K 
16: R1          Document and Entity Information                     HTML     63K 
17: R2          Consolidated Balance Sheets                         HTML     94K 
18: R3          Consolidated Balance Sheets (Parenthetical)         HTML     45K 
19: R4          Consolidated Statements of Operations and           HTML     68K 
                Comprehensive Loss                                               
20: R5          Consolidated Statements of Redeemable Convertible   HTML     98K 
                Preferred Stock and Stockholders' (Deficit) Equity               
21: R6          Consolidated Statements of Redeemable Convertible   HTML     30K 
                Preferred Stock and Stockholders' (Deficit) Equity               
                (Parenthetical)                                                  
22: R7          Consolidated Statements of Cash Flows               HTML    111K 
23: R8          Nature of the Business                              HTML     34K 
24: R9          Summary of Significant Accounting Policies          HTML    112K 
25: R10         Fair Value of Financial Assets and Liabilities      HTML     64K 
26: R11         Prepaid Expenses and Other Current Assets           HTML     33K 
27: R12         Property and Equipment, Net                         HTML     34K 
28: R13         Accrued Expenses                                    HTML     33K 
29: R14         Loan Agreement and Warrant to Purchase Preferred    HTML     33K 
                Stock                                                            
30: R15         Redeemable Convertible Preferred Stock              HTML     41K 
31: R16         Common Stock                                        HTML     46K 
32: R17         Stock-Based Compensation                            HTML     71K 
33: R18         License Agreements                                  HTML     53K 
34: R19         Income Taxes                                        HTML     64K 
35: R20         Net Loss per Share Attributable to Common           HTML     34K 
                Stockholders                                                     
36: R21         Commitments and Contingencies                       HTML     43K 
37: R22         Related Party Transactions                          HTML     37K 
38: R23         Benefit Plans                                       HTML     31K 
39: R24         Subsequent Events                                   HTML     29K 
40: R25         Summary of Significant Accounting Policies          HTML    157K 
                (Policies)                                                       
41: R26         Summary of Significant Accounting Policies          HTML     36K 
                (Tables)                                                         
42: R27         Fair Value of Financial Assets and Liabilities      HTML     64K 
                (Tables)                                                         
43: R28         Prepaid Expenses and Other Current Assets (Tables)  HTML     34K 
44: R29         Property and Equipment, Net (Tables)                HTML     34K 
45: R30         Accrued Expenses (Tables)                           HTML     32K 
46: R31         Redeemable Convertible Preferred Stock (Tables)     HTML     36K 
47: R32         Common Stock (Tables)                               HTML     43K 
48: R33         Stock-Based Compensation (Tables)                   HTML     62K 
49: R34         Income Taxes (Tables)                               HTML     52K 
50: R35         Net Loss per Share Attributable to Common           HTML     33K 
                Stockholders (Tables)                                            
51: R36         Commitments and Contingencies (Tables)              HTML     33K 
52: R37         Nature of the Business - Additional Information     HTML     38K 
                (Detail)                                                         
53: R38         Summary of Significant Accounting Policies -        HTML     44K 
                Additional Information (Detail)                                  
54: R39         Summary of Significant Accounting Policies -        HTML     36K 
                Estimated Useful Lives of Property and Equipment                 
                (Detail)                                                         
55: R40         Summary of Significant Accounting Policies -        HTML     38K 
                Statements of cash flows subsequent to the                       
                adoption of ASU (Detail)                                         
56: R41         Fair Value of Financial Assets and Liabilities -    HTML     51K 
                Summary of Financial Assets and Liabilities                      
                Measured at Fair Value on Recurring Basis (Detail)               
57: R42         Fair Value of Financial Assets and Liabilities -    HTML     48K 
                Additional Information (Detail)                                  
58: R43         Fair Value of Financial Assets and Liabilities -    HTML     39K 
                Summary of Changes in Fair Value of Preferred                    
                Stock Warrant Liability for Fair Value Determined                
                by Level 3 Inputs (Detail)                                       
59: R44         Fair Value of Financial Assets and Liabilities -    HTML     37K 
                Summary of Changes in Fair Value of Derivative                   
                Liability for Fair Value Determined by Level 3                   
                Inputs (Detail)                                                  
60: R45         Prepaid Expenses and Other Current Assets -         HTML     45K 
                Summary of Prepaid Expenses and Other Current                    
                Assets (Detail)                                                  
61: R46         Property and Equipment, Net - Summary of Property   HTML     42K 
                and Equipment, Net (Detail)                                      
62: R47         Property and Equipment, Net - Additional            HTML     29K 
                Information (Detail)                                             
63: R48         Accrued Expenses - Summary of Accrued Expenses and  HTML     41K 
                Other Current Liabilities (Detail)                               
64: R49         Loan Agreement and Warrant to Purchase Preferred    HTML     61K 
                Stock - Additional Information (Detail)                          
65: R50         Redeemable Convertible Preferred Stock -            HTML     81K 
                Additional Information (Detail)                                  
66: R51         Redeemable Convertible Preferred Stock - Summary    HTML     59K 
                of Preferred Stock (Detail)                                      
67: R52         Common Stock - Additional Information (Detail)      HTML     66K 
68: R53         Common Stock - Summary of Common Stock Reserved     HTML     44K 
                for Future Issuance (Detail)                                     
69: R54         Stock-Based Compensation - Additional Information   HTML     66K 
                (Detail)                                                         
70: R55         Stock-Based Compensation - Summary of Assumptions   HTML     37K 
                that Used to Determine Grant-Date Fair Value of                  
                Stock Options Granted to Employees and Members of                
                Board (Detail)                                                   
71: R56         Stock-Based Compensation - Summary of Stock Option  HTML     72K 
                Activity (Detail)                                                
72: R57         Stock-Based Compensation - Summary of Restricted    HTML     40K 
                Stock Unit Activity (Detail)                                     
73: R58         Stock-Based Compensation - Schedule of Stock-based  HTML     34K 
                Compensation Expense (Detail)                                    
74: R59         License Agreements - Additional Information         HTML     83K 
                (Detail)                                                         
75: R60         Income Taxes - Additional Information (Detail)      HTML     79K 
76: R61         Income Taxes - Schedule of Reconciliation of        HTML     54K 
                Income Tax Expense (Benefit) (Detail)                            
77: R62         Income Taxes - Schedule of Deferred Tax Assets and  HTML     60K 
                Liabilities (Detail)                                             
78: R63         Net Loss per Share - Schedule of Dilutive Common    HTML     38K 
                Stock Equivalents Excluded from Computation of                   
                Diluted Net Loss per Share (Detail)                              
79: R64         Commitments and Contingencies - Additional          HTML     42K 
                Information (Detail)                                             
80: R65         Commitments and Contingencies - Schedule Of Future  HTML     43K 
                Minimum Rental Payment Under Operating Lease                     
                (Detail)                                                         
81: R66         Related Party Transactions - Additional             HTML     66K 
                information (Detail)                                             
82: R67         Benefit Plans - Additional Information (Detail)     HTML     30K 
84: XML         IDEA XML File -- Filing Summary                      XML    152K 
83: EXCEL       IDEA Workbook of Financial Reports                  XLSX     87K 
10: EX-101.INS  XBRL Instance -- avro-20181231                       XML   1.21M 
12: EX-101.CAL  XBRL Calculations -- avro-20181231_cal               XML    169K 
13: EX-101.DEF  XBRL Definitions -- avro-20181231_def                XML    511K 
14: EX-101.LAB  XBRL Labels -- avro-20181231_lab                     XML   1.25M 
15: EX-101.PRE  XBRL Presentations -- avro-20181231_pre              XML    884K 
11: EX-101.SCH  XBRL Schema -- avro-20181231                         XSD    187K 
85: ZIP         XBRL Zipped Folder -- 0001193125-19-085321-xbrl      Zip    162K

‘EX-101.SCH’   —   XBRL Schema — avro-20181231

This Exhibit is an XBRL XML File.

                                                                                                                                                                                
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<element name="EffectiveIncomeTaxRateReconciliationTaxCutsAndJobsAct2017Percent" id="avro_EffectiveIncomeTaxRateReconciliationTaxCutsAndJobsAct2017Percent" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="EmergingGrowthCompanyStatusPolicyTextBlock" id="avro_EmergingGrowthCompanyStatusPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ExercisableWarrantsToPurchaseCommonStock" id="avro_ExercisableWarrantsToPurchaseCommonStock" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ExpirationThrough2033Member" id="avro_ExpirationThrough2033Member" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ExpirationThrough2037Member" id="avro_ExpirationThrough2037Member" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ExpirationThrough2038Member" id="avro_ExpirationThrough2038Member" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="FabrylicenseagreementMember" id="avro_FabrylicenseagreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="FairValueInputAmountTransferBetweenLevels" id="avro_FairValueInputAmountTransferBetweenLevels" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityConversionPreferredWarrantsToCommonStockWarrants" id="avro_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityConversionPreferredWarrantsToCommonStockWarrants" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityWarrantToPurchaseRedeemableConvertiblePreferredStock" id="avro_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityWarrantToPurchaseRedeemableConvertiblePreferredStock" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="FairValueOfAssetsAndLiabilitiesMeasuredOnNonRecurringBasisLineItems" id="avro_FairValueOfAssetsAndLiabilitiesMeasuredOnNonRecurringBasisLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="FairValueOfWarrantsAtIssuance" id="avro_FairValueOfWarrantsAtIssuance" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ForeignExchangeLoss" id="avro_ForeignExchangeLoss" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="GenstemTherapeuticsIncMember" id="avro_GenstemTherapeuticsIncMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="IncreaseDecreaseInDeferredTaxAssets" id="avro_IncreaseDecreaseInDeferredTaxAssets" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="Interleukin12LicenseAgreementMember" id="avro_Interleukin12LicenseAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="IssuanceOfCommonStock" id="avro_IssuanceOfCommonStock" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="IssuanceOfCommonStockNetOfIssuanceCosts" id="avro_IssuanceOfCommonStockNetOfIssuanceCosts" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="IssuanceOfWarrantsInConnectionWithDebt" id="avro_IssuanceOfWarrantsInConnectionWithDebt" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LicenseAgreementDisclosureTextBlock" id="avro_LicenseAgreementDisclosureTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LicenseAgreementExpenses" id="avro_LicenseAgreementExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LicenseAgreementLineItems" id="avro_LicenseAgreementLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LicenseAgreementMember" id="avro_LicenseAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LicenseAgreementsAbstract" id="avro_LicenseAgreementsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LicenseAgreementTable" id="avro_LicenseAgreementTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem"/>
<element name="LicenseMaintenanceFees" id="avro_LicenseMaintenanceFees" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LoanAgreementAndWarrantToPurchasePreferredStockDisclosureTextBlock" id="avro_LoanAgreementAndWarrantToPurchasePreferredStockDisclosureTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LundUniversityRightsHoldersAgreementMember" id="avro_LundUniversityRightsHoldersAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="MilestonePayment" id="avro_MilestonePayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="MilestonePayments" id="avro_MilestonePayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NetIncomeLossAvailableToCommonStockholdersBasicAndDiluted" id="avro_NetIncomeLossAvailableToCommonStockholdersBasicAndDiluted" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NetIncomeLossPerShareAttributableToCommonStockholdersPolicyTextBlock" id="avro_NetIncomeLossPerShareAttributableToCommonStockholdersPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NumberOfSharesOfCommonStockOutstandingIncreasePercentage" id="avro_NumberOfSharesOfCommonStockOutstandingIncreasePercentage" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="OfficersAndBoardMembersMember" id="avro_OfficersAndBoardMembersMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="OperatingLeaseAnnualIncreaseInRentalPercentage" id="avro_OperatingLeaseAnnualIncreaseInRentalPercentage" type="num:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="OperatingLossAndTaxCreditCarryforwardsLimitationsPeriodOverWhichCumulativeChangesInOwnershipInterestOfSignificantShareholdersConsidered" id="avro_OperatingLossAndTaxCreditCarryforwardsLimitationsPeriodOverWhichCumulativeChangesInOwnershipInterestOfSignificantShareholdersConsidered" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="OperatingLossAndTaxCreditCarryforwardsLimitationsThresholdPercentageOfCumulativeChangesInOwnershipInterestOfSignificantShareholdersConsidered" id="avro_OperatingLossAndTaxCreditCarryforwardsLimitationsThresholdPercentageOfCumulativeChangesInOwnershipInterestOfSignificantShareholdersConsidered" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="OptionFee" id="avro_OptionFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PaymentOfDilutionLiability" id="avro_PaymentOfDilutionLiability" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PaymentsUponClosingOfInitialPublicOffering" id="avro_PaymentsUponClosingOfInitialPublicOffering" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PayrollTaxLiabilityCappedPerYear" id="avro_PayrollTaxLiabilityCappedPerYear" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PrepaidExpensesAndOtherCurrentAssetsDisclosureTextBlock" id="avro_PrepaidExpensesAndOtherCurrentAssetsDisclosureTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PrepaidResearchAndDevelopmentCostsCurrent" id="avro_PrepaidResearchAndDevelopmentCostsCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PropertyAndEquipmentHeldForSale" id="avro_PropertyAndEquipmentHeldForSale" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ProvisionForMaximumCashPayment" id="avro_ProvisionForMaximumCashPayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PurchasesOfPropertyAndEquipmentPaidForByLandlord" id="avro_PurchasesOfPropertyAndEquipmentPaidForByLandlord" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="RecentlyAdoptedAccountingPronouncementsPolicyTextBlock" id="avro_RecentlyAdoptedAccountingPronouncementsPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="RestrictedCashMember" id="avro_RestrictedCashMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SalesMilestoneMember" id="avro_SalesMilestoneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ScheduleOfPropertyPlantAndEquipmentEstimatedUsefulLifeTableTextBlock" id="avro_ScheduleOfPropertyPlantAndEquipmentEstimatedUsefulLifeTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SeriesAConvertiblePreferredStockMember" id="avro_SeriesAConvertiblePreferredStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SeriesARedeemableConvertiblePreferredStockMember" id="avro_SeriesARedeemableConvertiblePreferredStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SeriesBConvertiblePreferredStockMember" id="avro_SeriesBConvertiblePreferredStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SeriesBRedeemableConvertiblePreferredStockMember" id="avro_SeriesBRedeemableConvertiblePreferredStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SeriesSeedConvertiblePreferredStockMember" id="avro_SeriesSeedConvertiblePreferredStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedAndExpirationsInPeriod" id="avro_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedAndExpirationsInPeriod" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsUnvested" id="avro_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsUnvested" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsUnvestedAggregateIntrinsicValue" id="avro_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsUnvestedAggregateIntrinsicValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsUnvestedWeightedAverageExercisePrice" id="avro_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsUnvestedWeightedAverageExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsUnvestedWeightedAverageRemainingContractualTerm1" id="avro_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsUnvestedWeightedAverageRemainingContractualTerm1" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SignificantAccountingPoliciesAbstract" id="avro_SignificantAccountingPoliciesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SignificantOfAccountingPoliciesLineItems" id="avro_SignificantOfAccountingPoliciesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SignificantOfAccountingPoliciesTable" id="avro_SignificantOfAccountingPoliciesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem"/>
<element name="StockIssuedDuringPeriodSharesWarrantsExercised" id="avro_StockIssuedDuringPeriodSharesWarrantsExercised" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="StockIssuedDuringPeriodValueWarrantsExercised" id="avro_StockIssuedDuringPeriodValueWarrantsExercised" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="StockPurchaseAgreementMember" id="avro_StockPurchaseAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SubleaseAgreementMember" id="avro_SubleaseAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TaxCreditCarryforwardsExpirationPeriod" id="avro_TaxCreditCarryforwardsExpirationPeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TaxIncentiveRefundCurrent" id="avro_TaxIncentiveRefundCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TemporaryEquityIssuanceOfRedeemableConvertiblePreferredStockNetOfIssuanceCosts" id="avro_TemporaryEquityIssuanceOfRedeemableConvertiblePreferredStockNetOfIssuanceCosts" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TemporaryEquityReservedForFutureIssuance" id="avro_TemporaryEquityReservedForFutureIssuance" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TemporaryEquitySharesIssuedForDividendsShares" id="avro_TemporaryEquitySharesIssuedForDividendsShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TemporaryEquitySharesIssuedForDividendsValue" id="avro_TemporaryEquitySharesIssuedForDividendsValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TemporaryEquityStockIssuanceCosts" id="avro_TemporaryEquityStockIssuanceCosts" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TemporaryEquityStockIssuedDuringPeriodShareNewIssues" id="avro_TemporaryEquityStockIssuedDuringPeriodShareNewIssues" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TemporaryEquityStockIssuedDuringPeriodSharesNewIssuesToSettledAccruedLiabilityOfLicense" id="avro_TemporaryEquityStockIssuedDuringPeriodSharesNewIssuesToSettledAccruedLiabilityOfLicense" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TemporaryEquityStockIssuedDuringPeriodValueNewIssuesToSettledAccruedLiabilityOfLicenseCost" id="avro_TemporaryEquityStockIssuedDuringPeriodValueNewIssuesToSettledAccruedLiabilityOfLicenseCost" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TemporaryEquityTextBlock" id="avro_TemporaryEquityTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TwoThousandEighteenEmployeeStockPurchasePlanMember" id="avro_TwoThousandEighteenEmployeeStockPurchasePlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TwoThousandEighteenStockOptionAndIncentivePlanMember" id="avro_TwoThousandEighteenStockOptionAndIncentivePlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TwoThousandFifteenStockOptionAndGrantPlanMember" id="avro_TwoThousandFifteenStockOptionAndGrantPlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="UHNagreementMember" id="avro_UHNagreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="UndesignatedPreferredStock" id="avro_UndesignatedPreferredStock" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="UndesignatedPreferredStockOutstanding" id="avro_UndesignatedPreferredStockOutstanding" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="UpfrontLicenseFees" id="avro_UpfrontLicenseFees" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="UpfrontPaymentPaidInCash" id="avro_UpfrontPaymentPaidInCash" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WarrantsToPurchaseRedeemableConvertiblePreferredStockMember" id="avro_WarrantsToPurchaseRedeemableConvertiblePreferredStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
</schema>

10 Subsequent Filings that Reference this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 4/29/24  AVROBIO, Inc.                     S-4/A                 80:15M                                    Donnelley … Solutions/FA
 4/15/24  AVROBIO, Inc.                     S-4/A                 91:17M                                    Donnelley … Solutions/FA
 3/26/24  AVROBIO, Inc.                     S-4/A       3/25/24   89:18M                                    Donnelley … Solutions/FA
 3/14/24  AVROBIO, Inc.                     10-K       12/31/23   80:9.4M                                   Donnelley … Solutions/FA
 2/14/24  AVROBIO, Inc.                     S-4                   91:25M                                    Donnelley … Solutions/FA
 3/23/23  AVROBIO, Inc.                     10-K       12/31/22   82:10M                                    Donnelley … Solutions/FA
 3/17/22  AVROBIO, Inc.                     10-K       12/31/21   78:9.1M                                   ActiveDisclosure/FA
 3/18/21  AVROBIO, Inc.                     10-K       12/31/20   73:9.1M                                   ActiveDisclosure/FA
11/20/20  AVROBIO, Inc.                     424B5                  1:5.2M                                   Donnelley … Solutions/FA
11/19/20  AVROBIO, Inc.                     424B5                  1:5.1M                                   Donnelley … Solutions/FA
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Filing Submission 0001193125-19-085321   –   Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)
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