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AVROBIO, Inc. – ‘S-4/A’ on 3/25/24 – ‘EX-101.DEF’

On:  Monday, 3/25/24, at 6:21pm ET   ·   As of:  3/26/24   ·   Accession #:  1193125-24-76669   ·   File #:  333-277048

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  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 3/26/24  AVROBIO, Inc.                     S-4/A       3/25/24   89:18M                                    Donnelley … Solutions/FA

Pre-Effective Amendment to Registration Statement – Securities for a Merger   —   Form S-4   —   SA’33

Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: S-4/A       Pre-Effective Amendment to Registration Statement   HTML   6.92M 
                - Securities for a Merger                                        
 2: EX-5.1      Opinion of Counsel re: Legality                     HTML     29K 
 3: EX-10.35    Material Contract                                   HTML    164K 
 4: EX-10.36    Material Contract                                   HTML    177K 
 5: EX-10.37    Material Contract                                   HTML     93K 
 6: EX-10.38    Material Contract                                   HTML    112K 
 7: EX-10.39    Material Contract                                   HTML    190K 
 8: EX-10.40    Material Contract                                   HTML    149K 
 9: EX-21.1     Subsidiaries List                                   HTML     23K 
10: EX-23.1     Consent of Expert or Counsel                        HTML     24K 
11: EX-23.2     Consent of Expert or Counsel                        HTML     24K 
13: EX-FILING FEES  Filing Fees                                     HTML     44K 
12: EX-99.10    Miscellaneous Exhibit                               HTML     27K 
24: R1          Cover Page                                          HTML     59K 
25: R2          Consolidated Balance Sheets                         HTML    114K 
26: R3          Consolidated Balance Sheets (Parenthetical)         HTML     46K 
27: R4          Consolidated Statements Of Operations And           HTML     84K 
                Comprehensive Income (Loss)                                      
28: R5          Consolidated Statements of Stockholders' Equity     HTML     66K 
29: R6          Consolidated Statements of Cash Flows               HTML    118K 
30: R7          Nature of the Business                              HTML     36K 
31: R8          Summary of Significant Accounting Policies          HTML     70K 
32: R9          License and Purchase Agreements                     HTML     51K 
33: R10         Fair Value of Financial Assets and Liabilities      HTML     49K 
34: R11         Supplemental Balance Sheet Information              HTML     62K 
35: R12         Leases                                              HTML     44K 
36: R13         Note Payable                                        HTML     40K 
37: R14         Common Stock                                        HTML     49K 
38: R15         Stock-Based Compensation                            HTML     78K 
39: R16         401(k) Savings Plan                                 HTML     31K 
40: R17         Commitments and Contingencies                       HTML     34K 
41: R18         Income Taxes                                        HTML     73K 
42: R19         Net Income (Loss) per Share                         HTML     50K 
43: R20         Related Party Transactions                          HTML     32K 
44: R21         Restructuring                                       HTML     37K 
45: R22         Subsequent Events                                   HTML     30K 
46: R23         Summary of Significant Accounting Policies          HTML    109K 
                (Policies)                                                       
47: R24         Summary of Significant Accounting Policies          HTML     29K 
                (Tables)                                                         
48: R25         Fair Value of Financial Assets and Liabilities      HTML     48K 
                (Tables)                                                         
49: R26         Supplemental Balance Sheet Information (Tables)     HTML     67K 
50: R27         Leases (Tables)                                     HTML     43K 
51: R28         Note Payable (Tables)                               HTML     31K 
52: R29         Common Stock (Tables)                               HTML     41K 
53: R30         Stock-Based Compensation (Tables)                   HTML     68K 
54: R31         Income Taxes (Tables)                               HTML     67K 
55: R32         Net Income (Loss) per Share (Tables)                HTML     51K 
56: R33         Restructuring (Tables)                              HTML     32K 
57: R34         Nature of the Business - Additional Information     HTML     44K 
                (Detail)                                                         
58: R35         Summary of Significant Accounting Policies -        HTML     39K 
                Additional Information (Detail)                                  
59: R36         Summary of Significant Accounting Policies -        HTML     35K 
                Schedule of Property and Equipment Estimated                     
                Useful Life (Detail)                                             
60: R37         License and Purchase Agreements - Additional        HTML    104K 
                Information (Detail)                                             
61: R38         Fair Value of Financial Assets and Liabilities -    HTML     35K 
                Summary of Financial Assets and Liabilities                      
                Measured at Fair Value on Recurring Basis (Detail)               
62: R39         Fair Value of Financial Assets and Liabilities -    HTML     27K 
                Additional Information (Detail)                                  
63: R40         Supplemental Balance Sheet Information - Summary    HTML     37K 
                of Prepaid Expenses and Other Current Assets                     
                (Detail)                                                         
64: R41         Supplemental Balance Sheet Information - Summary    HTML     44K 
                of Property and Equipment, Net (Detail)                          
65: R42         Supplemental Balance Sheet Information -            HTML     28K 
                Additional Information (Detail)                                  
66: R43         Supplemental Balance Sheet Information - Summary    HTML     30K 
                of Restricted Cash (Detail)                                      
67: R44         Supplemental Balance Sheet Information - Summary    HTML     36K 
                of Accrued Expenses (Detail)                                     
68: R45         Leases - Additional Information (Detail)            HTML     47K 
69: R46         Leases - Schedule of effective lease cost           HTML     31K 
                comprehensive income loss (Details)                              
70: R47         Leases - Summary of Future Minimum Lease Payments   HTML     39K 
                Due Under Operating Leases (Details)                             
71: R48         Note Payable - Additional Information (Details)     HTML     76K 
72: R49         Note Payable - Carrying Value of Note Payable       HTML     32K 
                (Details)                                                        
73: R50         Common Stock - Additional Information (Detail)      HTML     70K 
74: R51         Common Stock - Summary of Common Stock Reserved     HTML     46K 
                for Future Issuance (Detail)                                     
75: R52         Stock-Based Compensation - Additional Information   HTML     91K 
                (Detail)                                                         
76: R53         Stock-Based Compensation - Summary of Assumptions   HTML     33K 
                that Used to Determine Grant-Date Fair Value of                  
                Stock Options Granted to Employees and Members of                
                Board (Detail)                                                   
77: R54         Stock-Based Compensation - Summary of Stock Option  HTML     61K 
                Activity (Detail)                                                
78: R55         Stock-Based Compensation - Summary of Restricted    HTML     55K 
                Stock Award and Restricted Stock Unit Activity                   
                (Detail)                                                         
79: R56         Stock-Based Compensation - Schedule of Stock-based  HTML     33K 
                Compensation Expense (Detail)                                    
80: R57         401(k) Savings Plan - Additional Information        HTML     33K 
                (Detail)                                                         
81: R58         Income Taxes - Additional Information (Detail)      HTML     62K 
82: R59         Income Taxes - Schedule of Reconciliation of        HTML     50K 
                Income Tax Expense (Benefit) (Detail)                            
83: R60         Income Taxes - Schedule of Deferred Tax Assets and  HTML     58K 
                Liabilities (Detail)                                             
84: R61         Net Income (Loss) Per Share - Components of Basic   HTML     56K 
                and Diluted Earnings Per Share (Details)                         
85: R62         Net Income (Loss) Per Share - Schedule of Dilutive  HTML     33K 
                Common Stock Equivalents Excluded from Computation               
                of Diluted Net Loss per Share (Detail)                           
86: R63         Related Party Transactions - Additional             HTML     44K 
                Information (Detail)                                             
87: R64         Restructuring - Additional Information (Details)    HTML     56K 
88: R65         Restructuring - Schedule of Restructuring           HTML     37K 
                Activities (Details)                                             
89: R66         Subsequent Events - Additional Information          HTML     33K 
                (Details)                                                        
20: XML         IDEA XML File -- Filing Summary                      XML    152K 
23: XML         XBRL Instance -- d770053ds4a_htm                     XML   1.23M 
19: EXCEL       IDEA Workbook of Financial Report Info              XLSX    150K 
15: EX-101.CAL  XBRL Calculations -- avro-20231231_cal               XML    112K 
16: EX-101.DEF  XBRL Definitions -- avro-20231231_def                XML    541K 
17: EX-101.LAB  XBRL Labels -- avro-20231231_lab                     XML   1.19M 
18: EX-101.PRE  XBRL Presentations -- avro-20231231_pre              XML    838K 
14: EX-101.SCH  XBRL Schema -- avro-20231231                         XSD    194K 
21: JSON        XBRL Instance as JSON Data -- MetaLinks              444±   653K 
22: ZIP         XBRL Zipped Folder -- 0001193125-24-076669-xbrl      Zip   3.19M

‘EX-101.DEF’   —   XBRL Definitions — avro-20231231_def

This Exhibit is an XBRL File.

                                                                                                                                                                                
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1 Subsequent Filing that References this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 4/15/24  AVROBIO, Inc.                     S-4/A                 91:17M                                    Donnelley … Solutions/FA

19 Previous Filings that this Filing References

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 2/14/24  AVROBIO, Inc.                     S-4                   91:25M                                    Donnelley … Solutions/FA
 8/10/23  AVROBIO, Inc.                     10-Q        6/30/23   69:9.5M                                   Donnelley … Solutions/FA
 3/23/23  AVROBIO, Inc.                     10-K       12/31/22   82:10M                                    Donnelley … Solutions/FA
 8/09/22  AVROBIO, Inc.                     10-Q        6/30/22   65:7.3M                                   Donnelley … Solutions/FA
 6/10/22  AVROBIO, Inc.                     8-K:5,9     6/08/22   11:205K                                   ActiveDisclosure/FA
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11/05/20  AVROBIO, Inc.                     10-Q        9/30/20   61:6.1M                                   ActiveDisclosure/FA
 6/09/20  AVROBIO, Inc.                     8-K:5,9     6/04/20    2:66K                                    ActiveDisclosure/FA
 3/16/20  AVROBIO, Inc.                     10-K       12/31/19   85:8.4M                                   ActiveDisclosure/FA
12/20/19  AVROBIO, Inc.                     S-8        12/20/19    4:170K                                   Donnelley … Solutions/FA
 3/25/19  AVROBIO, Inc.                     S-8         3/25/19    4:96K                                    Donnelley … Solutions/FA
 3/25/19  AVROBIO, Inc.                     10-K       12/31/18   85:7.2M                                   Donnelley … Solutions/FA
12/21/18  AVROBIO, Inc.                     8-K:5,7,9  12/17/18    3:177K                                   Donnelley … Solutions/FA
 6/25/18  AVROBIO, Inc.                     8-K:5,9     6/20/18    3:148K                                   Donnelley … Solutions/FA
 6/11/18  AVROBIO, Inc.                     S-1/A¶                18:5.4M                                   Donnelley … Solutions/FA
 6/01/18  AVROBIO, Inc.                     S-1/A                  3:497K                                   Donnelley … Solutions/FA
 5/25/18  AVROBIO, Inc.                     S-1                   15:5.5M                                   Donnelley … Solutions/FA
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