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AVROBIO, Inc. – ‘S-4/A’ on 3/25/24 – ‘EX-101.SCH’

On:  Monday, 3/25/24, at 6:21pm ET   ·   As of:  3/26/24   ·   Accession #:  1193125-24-76669   ·   File #:  333-277048

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  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 3/26/24  AVROBIO, Inc.                     S-4/A       3/25/24   89:18M                                    Donnelley … Solutions/FA

Pre-Effective Amendment to Registration Statement – Securities for a Merger   —   Form S-4   —   SA’33

Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: S-4/A       Pre-Effective Amendment to Registration Statement   HTML   6.92M 
                - Securities for a Merger                                        
 2: EX-5.1      Opinion of Counsel re: Legality                     HTML     29K 
 3: EX-10.35    Material Contract                                   HTML    164K 
 4: EX-10.36    Material Contract                                   HTML    177K 
 5: EX-10.37    Material Contract                                   HTML     93K 
 6: EX-10.38    Material Contract                                   HTML    112K 
 7: EX-10.39    Material Contract                                   HTML    190K 
 8: EX-10.40    Material Contract                                   HTML    149K 
 9: EX-21.1     Subsidiaries List                                   HTML     23K 
10: EX-23.1     Consent of Expert or Counsel                        HTML     24K 
11: EX-23.2     Consent of Expert or Counsel                        HTML     24K 
13: EX-FILING FEES  Filing Fees                                     HTML     44K 
12: EX-99.10    Miscellaneous Exhibit                               HTML     27K 
24: R1          Cover Page                                          HTML     59K 
25: R2          Consolidated Balance Sheets                         HTML    114K 
26: R3          Consolidated Balance Sheets (Parenthetical)         HTML     46K 
27: R4          Consolidated Statements Of Operations And           HTML     84K 
                Comprehensive Income (Loss)                                      
28: R5          Consolidated Statements of Stockholders' Equity     HTML     66K 
29: R6          Consolidated Statements of Cash Flows               HTML    118K 
30: R7          Nature of the Business                              HTML     36K 
31: R8          Summary of Significant Accounting Policies          HTML     70K 
32: R9          License and Purchase Agreements                     HTML     51K 
33: R10         Fair Value of Financial Assets and Liabilities      HTML     49K 
34: R11         Supplemental Balance Sheet Information              HTML     62K 
35: R12         Leases                                              HTML     44K 
36: R13         Note Payable                                        HTML     40K 
37: R14         Common Stock                                        HTML     49K 
38: R15         Stock-Based Compensation                            HTML     78K 
39: R16         401(k) Savings Plan                                 HTML     31K 
40: R17         Commitments and Contingencies                       HTML     34K 
41: R18         Income Taxes                                        HTML     73K 
42: R19         Net Income (Loss) per Share                         HTML     50K 
43: R20         Related Party Transactions                          HTML     32K 
44: R21         Restructuring                                       HTML     37K 
45: R22         Subsequent Events                                   HTML     30K 
46: R23         Summary of Significant Accounting Policies          HTML    109K 
                (Policies)                                                       
47: R24         Summary of Significant Accounting Policies          HTML     29K 
                (Tables)                                                         
48: R25         Fair Value of Financial Assets and Liabilities      HTML     48K 
                (Tables)                                                         
49: R26         Supplemental Balance Sheet Information (Tables)     HTML     67K 
50: R27         Leases (Tables)                                     HTML     43K 
51: R28         Note Payable (Tables)                               HTML     31K 
52: R29         Common Stock (Tables)                               HTML     41K 
53: R30         Stock-Based Compensation (Tables)                   HTML     68K 
54: R31         Income Taxes (Tables)                               HTML     67K 
55: R32         Net Income (Loss) per Share (Tables)                HTML     51K 
56: R33         Restructuring (Tables)                              HTML     32K 
57: R34         Nature of the Business - Additional Information     HTML     44K 
                (Detail)                                                         
58: R35         Summary of Significant Accounting Policies -        HTML     39K 
                Additional Information (Detail)                                  
59: R36         Summary of Significant Accounting Policies -        HTML     35K 
                Schedule of Property and Equipment Estimated                     
                Useful Life (Detail)                                             
60: R37         License and Purchase Agreements - Additional        HTML    104K 
                Information (Detail)                                             
61: R38         Fair Value of Financial Assets and Liabilities -    HTML     35K 
                Summary of Financial Assets and Liabilities                      
                Measured at Fair Value on Recurring Basis (Detail)               
62: R39         Fair Value of Financial Assets and Liabilities -    HTML     27K 
                Additional Information (Detail)                                  
63: R40         Supplemental Balance Sheet Information - Summary    HTML     37K 
                of Prepaid Expenses and Other Current Assets                     
                (Detail)                                                         
64: R41         Supplemental Balance Sheet Information - Summary    HTML     44K 
                of Property and Equipment, Net (Detail)                          
65: R42         Supplemental Balance Sheet Information -            HTML     28K 
                Additional Information (Detail)                                  
66: R43         Supplemental Balance Sheet Information - Summary    HTML     30K 
                of Restricted Cash (Detail)                                      
67: R44         Supplemental Balance Sheet Information - Summary    HTML     36K 
                of Accrued Expenses (Detail)                                     
68: R45         Leases - Additional Information (Detail)            HTML     47K 
69: R46         Leases - Schedule of effective lease cost           HTML     31K 
                comprehensive income loss (Details)                              
70: R47         Leases - Summary of Future Minimum Lease Payments   HTML     39K 
                Due Under Operating Leases (Details)                             
71: R48         Note Payable - Additional Information (Details)     HTML     76K 
72: R49         Note Payable - Carrying Value of Note Payable       HTML     32K 
                (Details)                                                        
73: R50         Common Stock - Additional Information (Detail)      HTML     70K 
74: R51         Common Stock - Summary of Common Stock Reserved     HTML     46K 
                for Future Issuance (Detail)                                     
75: R52         Stock-Based Compensation - Additional Information   HTML     91K 
                (Detail)                                                         
76: R53         Stock-Based Compensation - Summary of Assumptions   HTML     33K 
                that Used to Determine Grant-Date Fair Value of                  
                Stock Options Granted to Employees and Members of                
                Board (Detail)                                                   
77: R54         Stock-Based Compensation - Summary of Stock Option  HTML     61K 
                Activity (Detail)                                                
78: R55         Stock-Based Compensation - Summary of Restricted    HTML     55K 
                Stock Award and Restricted Stock Unit Activity                   
                (Detail)                                                         
79: R56         Stock-Based Compensation - Schedule of Stock-based  HTML     33K 
                Compensation Expense (Detail)                                    
80: R57         401(k) Savings Plan - Additional Information        HTML     33K 
                (Detail)                                                         
81: R58         Income Taxes - Additional Information (Detail)      HTML     62K 
82: R59         Income Taxes - Schedule of Reconciliation of        HTML     50K 
                Income Tax Expense (Benefit) (Detail)                            
83: R60         Income Taxes - Schedule of Deferred Tax Assets and  HTML     58K 
                Liabilities (Detail)                                             
84: R61         Net Income (Loss) Per Share - Components of Basic   HTML     56K 
                and Diluted Earnings Per Share (Details)                         
85: R62         Net Income (Loss) Per Share - Schedule of Dilutive  HTML     33K 
                Common Stock Equivalents Excluded from Computation               
                of Diluted Net Loss per Share (Detail)                           
86: R63         Related Party Transactions - Additional             HTML     44K 
                Information (Detail)                                             
87: R64         Restructuring - Additional Information (Details)    HTML     56K 
88: R65         Restructuring - Schedule of Restructuring           HTML     37K 
                Activities (Details)                                             
89: R66         Subsequent Events - Additional Information          HTML     33K 
                (Details)                                                        
20: XML         IDEA XML File -- Filing Summary                      XML    152K 
23: XML         XBRL Instance -- d770053ds4a_htm                     XML   1.23M 
19: EXCEL       IDEA Workbook of Financial Report Info              XLSX    150K 
15: EX-101.CAL  XBRL Calculations -- avro-20231231_cal               XML    112K 
16: EX-101.DEF  XBRL Definitions -- avro-20231231_def                XML    541K 
17: EX-101.LAB  XBRL Labels -- avro-20231231_lab                     XML   1.19M 
18: EX-101.PRE  XBRL Presentations -- avro-20231231_pre              XML    838K 
14: EX-101.SCH  XBRL Schema -- avro-20231231                         XSD    194K 
21: JSON        XBRL Instance as JSON Data -- MetaLinks              444±   653K 
22: ZIP         XBRL Zipped Folder -- 0001193125-24-076669-xbrl      Zip   3.19M

‘EX-101.SCH’   —   XBRL Schema — avro-20231231

This Exhibit is an XBRL File.

                                                                                                                                                                                
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<link:definition> 1040 - Disclosure - Supplemental Balance Sheet Information - Summary of Prepaid Expenses and Other Current Assets (Detail) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.aw.com/role/SupplementalBalanceSheetInformationSummaryOfPropertyAndEquipmentNetDetail" id="SupplementalBalanceSheetInformationSummaryOfPropertyAndEquipmentNetDetail">
<link:definition> 1041 - Disclosure - Supplemental Balance Sheet Information - Summary of Property and Equipment, Net (Detail) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.aw.com/role/SupplementalBalanceSheetInformationAdditionalInformationDetail" id="SupplementalBalanceSheetInformationAdditionalInformationDetail">
<link:definition> 1042 - Disclosure - Supplemental Balance Sheet Information - Additional Information (Detail) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.aw.com/role/SupplementalBalanceSheetInformationSummaryOfRestrictedCashDetail" id="SupplementalBalanceSheetInformationSummaryOfRestrictedCashDetail">
<link:definition> 1043 - Disclosure - Supplemental Balance Sheet Information - Summary of Restricted Cash (Detail) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.aw.com/role/SupplementalBalanceSheetInformationSummaryOfAccruedExpensesDetail" id="SupplementalBalanceSheetInformationSummaryOfAccruedExpensesDetail">
<link:definition> 1044 - Disclosure - Supplemental Balance Sheet Information - Summary of Accrued Expenses (Detail) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.aw.com/role/LeasesAdditionalInformationDetail" id="LeasesAdditionalInformationDetail">
<link:definition> 1045 - Disclosure - Leases - Additional Information (Detail) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.aw.com/role/LeasesScheduleOfEffectiveLeaseCostComprehensiveIncomeLossDetails" id="LeasesScheduleOfEffectiveLeaseCostComprehensiveIncomeLossDetails">
<link:definition> 1046 - Disclosure - Leases - Schedule of effective lease cost comprehensive income loss (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.aw.com/role/LeasesSummaryOfFutureMinimumLeasePaymentsDueUnderOperatingLeasesDetails" id="LeasesSummaryOfFutureMinimumLeasePaymentsDueUnderOperatingLeasesDetails">
<link:definition> 1047 - Disclosure - Leases - Summary of Future Minimum Lease Payments Due Under Operating Leases (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.aw.com/role/NotePayableAdditionalInformationDetails" id="NotePayableAdditionalInformationDetails">
<link:definition> 1048 - Disclosure - Note Payable - Additional Information (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.aw.com/role/NotePayableCarryingValueOfNotePayableDetails" id="NotePayableCarryingValueOfNotePayableDetails">
<link:definition> 1049 - Disclosure - Note Payable - Carrying Value of Note Payable (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.aw.com/role/CommonStockAdditionalInformationDetail" id="CommonStockAdditionalInformationDetail">
<link:definition> 1050 - Disclosure - Common Stock - Additional Information (Detail) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.aw.com/role/CommonStockSummaryOfCommonStockReservedForFutureIssuanceDetail" id="CommonStockSummaryOfCommonStockReservedForFutureIssuanceDetail">
<link:definition> 1051 - Disclosure - Common Stock - Summary of Common Stock Reserved for Future Issuance (Detail) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.aw.com/role/StockBasedCompensationAdditionalInformationDetail" id="StockBasedCompensationAdditionalInformationDetail">
<link:definition> 1052 - Disclosure - Stock-Based Compensation - Additional Information (Detail) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.aw.com/role/StockBasedCompensationSummaryOfAssumptionsThatUsedToDetermineGrantDateFairValueOfStockOptionsGrantedToEmployeesAndMembersOfBoardDetail" id="StockBasedCompensationSummaryOfAssumptionsThatUsedToDetermineGrantDateFairValueOfStockOptionsGrantedToEmployeesAndMembersOfBoardDetail">
<link:definition> 1053 - Disclosure - Stock-Based Compensation - Summary of Assumptions that Used to Determine Grant-Date Fair Value of Stock Options Granted to Employees and Members of Board (Detail) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.aw.com/role/StockBasedCompensationSummaryOfStockOptionActivityDetail" id="StockBasedCompensationSummaryOfStockOptionActivityDetail">
<link:definition> 1054 - Disclosure - Stock-Based Compensation - Summary of Stock Option Activity (Detail) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.aw.com/role/StockBasedCompensationSummaryOfRestrictedStockAwardAndRestrictedStockUnitActivityDetail" id="StockBasedCompensationSummaryOfRestrictedStockAwardAndRestrictedStockUnitActivityDetail">
<link:definition> 1055 - Disclosure - Stock-Based Compensation - Summary of Restricted Stock Award and Restricted Stock Unit Activity (Detail) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.aw.com/role/StockBasedCompensationScheduleOfStockBasedCompensationExpenseDetail" id="StockBasedCompensationScheduleOfStockBasedCompensationExpenseDetail">
<link:definition> 1056 - Disclosure - Stock-Based Compensation - Schedule of Stock-based Compensation Expense (Detail) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.aw.com/role/KSavingsPlanAdditionalInformationDetail" id="KSavingsPlanAdditionalInformationDetail">
<link:definition> 1057 - Disclosure - 401(k) Savings Plan - Additional Information (Detail) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.aw.com/role/IncomeTaxesAdditionalInformationDetail" id="IncomeTaxesAdditionalInformationDetail">
<link:definition> 1058 - Disclosure - Income Taxes - Additional Information (Detail) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.aw.com/role/IncomeTaxesScheduleOfReconciliationOfIncomeTaxExpenseBenefitDetail" id="IncomeTaxesScheduleOfReconciliationOfIncomeTaxExpenseBenefitDetail">
<link:definition> 1059 - Disclosure - Income Taxes - Schedule of Reconciliation of Income Tax Expense (Benefit) (Detail) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.aw.com/role/IncomeTaxesScheduleOfDeferredTaxAssetsAndLiabilitiesDetail" id="IncomeTaxesScheduleOfDeferredTaxAssetsAndLiabilitiesDetail">
<link:definition> 1060 - Disclosure - Income Taxes - Schedule of Deferred Tax Assets and Liabilities (Detail) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.aw.com/role/NetIncomeLossPerShareComponentsOfBasicAndDilutedEarningsPerShareDetails" id="NetIncomeLossPerShareComponentsOfBasicAndDilutedEarningsPerShareDetails">
<link:definition> 1061 - Disclosure - Net Income (Loss) Per Share - Components of Basic and Diluted Earnings Per Share (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.aw.com/role/NetIncomeLossPerShareScheduleOfDilutiveCommonStockEquivalentsExcludedFromComputationOfDilutedNetLossPerShareDetail" id="NetIncomeLossPerShareScheduleOfDilutiveCommonStockEquivalentsExcludedFromComputationOfDilutedNetLossPerShareDetail">
<link:definition> 1062 - Disclosure - Net Income (Loss) Per Share - Schedule of Dilutive Common Stock Equivalents Excluded from Computation of Diluted Net Loss per Share (Detail) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.aw.com/role/RelatedPartyTransactionsAdditionalInformationDetail" id="RelatedPartyTransactionsAdditionalInformationDetail">
<link:definition> 1063 - Disclosure - Related Party Transactions - Additional Information (Detail) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.aw.com/role/RestructuringAdditionalInformationDetails" id="RestructuringAdditionalInformationDetails">
<link:definition> 1064 - Disclosure - Restructuring - Additional Information (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.aw.com/role/RestructuringScheduleOfRestructuringActivitiesDetails" id="RestructuringScheduleOfRestructuringActivitiesDetails">
<link:definition> 1065 - Disclosure - Restructuring - Schedule of Restructuring Activities (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.aw.com/role/SubsequentEventsAdditionalInformationDetails" id="SubsequentEventsAdditionalInformationDetails">
<link:definition> 1066 - Disclosure - Subsequent Events - Additional Information (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
</link:roleType>
<link:linkbaseRef xlink:type="simple" xlink:href="avro-20231231_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase"/>
<link:linkbaseRef xlink:type="simple" xlink:href="avro-20231231_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase"/>
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<import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
<import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
<import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd"/>
<import namespace="http://fasb.org/us-gaap/2023" schemaLocation="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd"/>
<import namespace="http://xbrl.sec.gov/country/2023" schemaLocation="https://xbrl.sec.gov/country/2023/country-2023.xsd"/>
<import namespace="http://xbrl.sec.gov/currency/2023" schemaLocation="https://xbrl.sec.gov/currency/2023/currency-2023.xsd"/>
<import namespace="http://xbrl.sec.gov/exch/2023" schemaLocation="https://xbrl.sec.gov/exch/2023/exch-2023.xsd"/>
<import namespace="http://xbrl.sec.gov/naics/2023" schemaLocation="https://xbrl.sec.gov/naics/2023/naics-2023.xsd"/>
<import namespace="http://xbrl.sec.gov/sic/2023" schemaLocation="https://xbrl.sec.gov/sic/2023/sic-2023.xsd"/>
<import namespace="http://xbrl.sec.gov/stpr/2023" schemaLocation="https://xbrl.sec.gov/stpr/2023/stpr-2023.xsd"/>
<import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd"/>
<import namespace="http://www.xbrl.org/2009/role/net" schemaLocation="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd"/>
<import namespace="http://www.xbrl.org/2009/arcrole/fact-explanatoryFact" schemaLocation="http://www.xbrl.org/lrr/arcrole/factExplanatory-2009-12-16.xsd"/>
<import namespace="http://xbrl.sec.gov/dei/2023" schemaLocation="https://xbrl.sec.gov/dei/2023/dei-2023.xsd"/>
<import namespace="http://fasb.org/us-types/2023" schemaLocation="https://xbrl.fasb.org/us-gaap/2023/elts/us-types-2023.xsd"/>
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<import namespace="http://fasb.org/srt/2023" schemaLocation="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd"/>
<import namespace="http://www.xbrl.org/dtr/type/2020-01-21" schemaLocation="https://www.xbrl.org/dtr/type/2020-01-21/types.xsd"/>
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<element name="CommonStockOfferingCostsIncurredButNotYetPaid" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_CommonStockOfferingCostsIncurredButNotYetPaid" substitutionGroup="xbrli:item" xbrli:balance="credit"/>
<element name="RepaymentOfNotePayableIncludingEndOfTermCharge" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_RepaymentOfNotePayableIncludingEndOfTermCharge" substitutionGroup="xbrli:item" xbrli:balance="credit"/>
<element name="ProceedsFromSaleOfPropertyPlantAndEquipments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_ProceedsFromSaleOfPropertyPlantAndEquipments" substitutionGroup="xbrli:item" xbrli:balance="debit"/>
<element name="GainLossOnExtinguishmentOfOperatingLease" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_GainLossOnExtinguishmentOfOperatingLease" substitutionGroup="xbrli:item" xbrli:balance="credit"/>
<element name="GainLossOnImpairmentOfLeaseholdImprovements" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_GainLossOnImpairmentOfLeaseholdImprovements" substitutionGroup="xbrli:item" xbrli:balance="debit"/>
<element name="NonCashInterestExpense" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_NonCashInterestExpense" substitutionGroup="xbrli:item" xbrli:balance="debit"/>
<element name="NonCashLeaseExpense" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_NonCashLeaseExpense" substitutionGroup="xbrli:item" xbrli:balance="debit"/>
<element name="CurrentAndNonCurrentOperatingLeaseLiabilities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_CurrentAndNonCurrentOperatingLeaseLiabilities" substitutionGroup="xbrli:item" xbrli:balance="credit"/>
<element name="LicenseAgreementsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_LicenseAgreementsAbstract" substitutionGroup="xbrli:item"/>
<element name="LicenseAgreementDisclosureTextBlock" type="dtr-types:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_LicenseAgreementDisclosureTextBlock" substitutionGroup="xbrli:item"/>
<element name="ScheduleOfPropertyPlantAndEquipmentEstimatedUsefulLifeTableTextBlock" type="dtr-types:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_ScheduleOfPropertyPlantAndEquipmentEstimatedUsefulLifeTableTextBlock" substitutionGroup="xbrli:item"/>
<element name="ScheduleOfEffectiveLeaseCostComprehensiveIncomeLossTableTextBlock" type="dtr-types:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_ScheduleOfEffectiveLeaseCostComprehensiveIncomeLossTableTextBlock" substitutionGroup="xbrli:item"/>
<element name="CashPaymentOfClosingTheTransaction" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="avro_CashPaymentOfClosingTheTransaction" substitutionGroup="xbrli:item" xbrli:balance="credit"/>
<element name="CompanyWorkforceReductionNumberOfEmployees" type="xbrli:integerItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="avro_CompanyWorkforceReductionNumberOfEmployees" substitutionGroup="xbrli:item"/>
<element name="ReductionInWorkforcePercentage" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="avro_ReductionInWorkforcePercentage" substitutionGroup="xbrli:item"/>
<element name="AssetPurchaseAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_AssetPurchaseAgreementMember" substitutionGroup="xbrli:item"/>
<element name="SignificantAccountingPoliciesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_SignificantAccountingPoliciesAbstract" substitutionGroup="xbrli:item"/>
<element name="SignificantOfAccountingPoliciesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_SignificantOfAccountingPoliciesTable" substitutionGroup="xbrldt:hypercubeItem"/>
<element name="SignificantOfAccountingPoliciesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_SignificantOfAccountingPoliciesLineItems" substitutionGroup="xbrli:item"/>
<element name="ForeignExchangeLoss" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_ForeignExchangeLoss" substitutionGroup="xbrli:item" xbrli:balance="debit"/>
<element name="PropertyPlantAndEquipmentEstimatedUsefulLife" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_PropertyPlantAndEquipmentEstimatedUsefulLife" substitutionGroup="xbrli:item"/>
<element name="LicenseAgreementTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_LicenseAgreementTable" substitutionGroup="xbrldt:hypercubeItem"/>
<element name="BioMarinPharmaceuticalIncMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_BioMarinPharmaceuticalIncMember" substitutionGroup="xbrli:item"/>
<element name="GenstemTherapeuticsIncMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_GenstemTherapeuticsIncMember" substitutionGroup="xbrli:item"/>
<element name="LundUniversityRightsHoldersAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_LundUniversityRightsHoldersAgreementMember" substitutionGroup="xbrli:item"/>
<element name="UHNagreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_UHNagreementMember" substitutionGroup="xbrli:item"/>
<element name="UniversityOfManchesterAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_UniversityOfManchesterAgreementMember" substitutionGroup="xbrli:item"/>
<element name="LicenseAgreementLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_LicenseAgreementLineItems" substitutionGroup="xbrli:item"/>
<element name="ClinicalTrialCostRelatedToResearchAndDevelopmentExpense" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_ClinicalTrialCostRelatedToResearchAndDevelopmentExpense" substitutionGroup="xbrli:item" xbrli:balance="debit"/>
<element name="CollaborativeAgreementExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_CollaborativeAgreementExpenses" substitutionGroup="xbrli:item" xbrli:balance="debit"/>
<element name="LicenseAgreementExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_LicenseAgreementExpenses" substitutionGroup="xbrli:item" xbrli:balance="debit"/>
<element name="LicenseMaintenanceFees" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_LicenseMaintenanceFees" substitutionGroup="xbrli:item" xbrli:balance="debit"/>
<element name="MilestoneFees" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_MilestoneFees" substitutionGroup="xbrli:item" xbrli:balance="debit"/>
<element name="MilestonePayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_MilestonePayment" substitutionGroup="xbrli:item" xbrli:balance="credit"/>
<element name="MilestonePaymentPaid" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_MilestonePaymentPaid" substitutionGroup="xbrli:item" xbrli:balance="credit"/>
<element name="MilestonePaymentToBePaid" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="avro_MilestonePaymentToBePaid" substitutionGroup="xbrli:item" xbrli:balance="credit"/>
<element name="OptionFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="avro_OptionFee" substitutionGroup="xbrli:item" xbrli:balance="credit"/>
<element name="PaymentsUponClosingOfInitialPublicOffering" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_PaymentsUponClosingOfInitialPublicOffering" substitutionGroup="xbrli:item" xbrli:balance="debit"/>
<element name="UpfrontLicenseFees" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_UpfrontLicenseFees" substitutionGroup="xbrli:item" xbrli:balance="credit"/>
<element name="FabrylicenseagreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_FabrylicenseagreementMember" substitutionGroup="xbrli:item"/>
<element name="Interleukin12LicenseAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_Interleukin12LicenseAgreementMember" substitutionGroup="xbrli:item"/>
<element name="MPSIILicenseAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_MPSIILicenseAgreementMember" substitutionGroup="xbrli:item"/>
<element name="SaleOfCystinosisProgramMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_SaleOfCystinosisProgramMember" substitutionGroup="xbrli:item"/>
<element name="FairValueInputAmountTransferBetweenLevels" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="avro_FairValueInputAmountTransferBetweenLevels" substitutionGroup="xbrli:item" xbrli:balance="credit"/>
<element name="SupplementalBalanceSheetInformationDisclosuresAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_SupplementalBalanceSheetInformationDisclosuresAbstract" substitutionGroup="xbrli:item"/>
<element name="PrepaidCompensationBenefits" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="avro_PrepaidCompensationBenefits" substitutionGroup="xbrli:item" xbrli:balance="debit"/>
<element name="PrepaidResearchAndDevelopmentCostsCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="avro_PrepaidResearchAndDevelopmentCostsCurrent" substitutionGroup="xbrli:item" xbrli:balance="debit"/>
<element name="TaxIncentiveRefundCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="avro_TaxIncentiveRefundCurrent" substitutionGroup="xbrli:item" xbrli:balance="debit"/>
<element name="SaleOfAssets" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="avro_SaleOfAssets" substitutionGroup="xbrli:item" xbrli:balance="credit"/>
<element name="AccruedResearchAndDevelopmentExpenseCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="avro_AccruedResearchAndDevelopmentExpenseCurrent" substitutionGroup="xbrli:item" xbrli:balance="credit"/>
<element name="RestrictedCashMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_RestrictedCashMember" substitutionGroup="xbrli:item"/>
<element name="AnnualLeasePaymentsDescription" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_AnnualLeasePaymentsDescription" substitutionGroup="xbrli:item"/>
<element name="CashPaymentsForOperatingLeases" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_CashPaymentsForOperatingLeases" substitutionGroup="xbrli:item" xbrli:balance="debit"/>
<element name="LeaseExpirationMonthAndYear" type="xbrli:gYearMonthItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_LeaseExpirationMonthAndYear" substitutionGroup="xbrli:item"/>
<element name="OperatingLeaseAnnualIncreaseInRentalPercentage" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="avro_OperatingLeaseAnnualIncreaseInRentalPercentage" substitutionGroup="xbrli:item"/>
<element name="Operatingleasesfutureminimumpaymentdue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_Operatingleasesfutureminimumpaymentdue" substitutionGroup="xbrli:item" xbrli:balance="credit"/>
<element name="OperatingLeasesFutureMinimumPaymentDueCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_OperatingLeasesFutureMinimumPaymentDueCurrent" substitutionGroup="xbrli:item" xbrli:balance="credit"/>
<element name="OperatingLeasesFutureMinimumPaymentDueInFourYears" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_OperatingLeasesFutureMinimumPaymentDueInFourYears" substitutionGroup="xbrli:item" xbrli:balance="credit"/>
<element name="OperatingLeasesFutureMinimumPaymentDueInThreeYears" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_OperatingLeasesFutureMinimumPaymentDueInThreeYears" substitutionGroup="xbrli:item" xbrli:balance="credit"/>
<element name="OperatingLeasesFutureMinimumPaymentDueInTwoYears" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_OperatingLeasesFutureMinimumPaymentDueInTwoYears" substitutionGroup="xbrli:item" xbrli:balance="credit"/>
<element name="OperatingLeasesFutureMinimumPaymentDueThereafter" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_OperatingLeasesFutureMinimumPaymentDueThereafter" substitutionGroup="xbrli:item" xbrli:balance="credit"/>
<element name="DebtDisclosureTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_DebtDisclosureTable" substitutionGroup="xbrldt:hypercubeItem"/>
<element name="TermLoanFacilityMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_TermLoanFacilityMember" substitutionGroup="xbrli:item"/>
<element name="TermLoanPrepaymentAfterSecondYearMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_TermLoanPrepaymentAfterSecondYearMember" substitutionGroup="xbrli:item"/>
<element name="TermLoanPrepaymentDuringFirstYearMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_TermLoanPrepaymentDuringFirstYearMember" substitutionGroup="xbrli:item"/>
<element name="TermLoanPrepaymentDuringSecondYearMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_TermLoanPrepaymentDuringSecondYearMember" substitutionGroup="xbrli:item"/>
<element name="DebtDisclosureLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_DebtDisclosureLineItems" substitutionGroup="xbrli:item"/>
<element name="DebtInstrumentNumberOfTranches" type="xbrli:integerItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_DebtInstrumentNumberOfTranches" substitutionGroup="xbrli:item"/>
<element name="EndOfTermChargeAsPercentageOnPrincipalAmount" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_EndOfTermChargeAsPercentageOnPrincipalAmount" substitutionGroup="xbrli:item"/>
<element name="LineOfCreditFacilityAdditionalDiscretionary" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="avro_LineOfCreditFacilityAdditionalDiscretionary" substitutionGroup="xbrli:item" xbrli:balance="credit"/>
<element name="LineOfCreditFacilityPrepaymentOfPremiumPercentage" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_LineOfCreditFacilityPrepaymentOfPremiumPercentage" substitutionGroup="xbrli:item"/>
<element name="RegulatoryMilestoneMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_RegulatoryMilestoneMember" substitutionGroup="xbrli:item"/>
<element name="LegalExpensesMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_LegalExpensesMember" substitutionGroup="xbrli:item"/>
<element name="SiliconValleyBankMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_SiliconValleyBankMember" substitutionGroup="xbrli:item"/>
<element name="LoanAndSecurityAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_LoanAndSecurityAgreementMember" substitutionGroup="xbrli:item"/>
<element name="UndesignatedPreferredStock" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="avro_UndesignatedPreferredStock" substitutionGroup="xbrli:item"/>
<element name="UndesignatedSharesOfPreferredStockOutstanding" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="avro_UndesignatedSharesOfPreferredStockOutstanding" substitutionGroup="xbrli:item"/>
<element name="AtTheMarketFacilityMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_AtTheMarketFacilityMember" substitutionGroup="xbrli:item"/>
<element name="FebruaryTwoThousandTwentyFollowOnOfferingMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_FebruaryTwoThousandTwentyFollowOnOfferingMember" substitutionGroup="xbrli:item"/>
<element name="JulyTwoThousandNineteenFollowOnOfferingMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_JulyTwoThousandNineteenFollowOnOfferingMember" substitutionGroup="xbrli:item"/>
<element name="NovemberTwoThousandTwentyFollowOnOfferingMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_NovemberTwoThousandTwentyFollowOnOfferingMember" substitutionGroup="xbrli:item"/>
<element name="TwoThousandEighteenEmployeeStockPurchasePlanMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_TwoThousandEighteenEmployeeStockPurchasePlanMember" substitutionGroup="xbrli:item"/>
<element name="TwoThousandEighteenStockOptionAndIncentivePlanMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_TwoThousandEighteenStockOptionAndIncentivePlanMember" substitutionGroup="xbrli:item"/>
<element name="TwoThousandNineteenInducementPlanMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_TwoThousandNineteenInducementPlanMember" substitutionGroup="xbrli:item"/>
<element name="TwoThousandTwentyInducementPlanMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_TwoThousandTwentyInducementPlanMember" substitutionGroup="xbrli:item"/>
<element name="TwoThousandFifteenStockOptionAndGrantPlanMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_TwoThousandFifteenStockOptionAndGrantPlanMember" substitutionGroup="xbrli:item"/>
<element name="NumberOfSharesOfCommonStockOutstandingIncreasePercentage" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_NumberOfSharesOfCommonStockOutstandingIncreasePercentage" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAllocateAdditionalShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_ShareBasedCompensationArrangementByShareBasedPaymentAwardAllocateAdditionalShares" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedAndExpirationsInPeriod" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedAndExpirationsInPeriod" substitutionGroup="xbrli:item"/>
<element name="IncomeTaxesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_IncomeTaxesTable" substitutionGroup="xbrldt:hypercubeItem"/>
<element name="IncomeTaxesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_IncomeTaxesLineItems" substitutionGroup="xbrli:item"/>
<element name="DecreasedDeferredTaxAssetsValuationAllowance" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_DecreasedDeferredTaxAssetsValuationAllowance" substitutionGroup="xbrli:item" xbrli:balance="debit"/>
<element name="OperatingLossAndTaxCreditCarryforwardsLimitationsPeriodOverWhichCumulativeChangesInOwnershipInterestOfSignificantShareholdersConsidered" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_OperatingLossAndTaxCreditCarryforwardsLimitationsPeriodOverWhichCumulativeChangesInOwnershipInterestOfSignificantShareholdersConsidered" substitutionGroup="xbrli:item"/>
<element name="OperatingLossAndTaxCreditCarryforwardsLimitationsThresholdPercentageOfCumulativeChangesInOwnershipInterestOfSignificantShareholdersConsidered" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_OperatingLossAndTaxCreditCarryforwardsLimitationsThresholdPercentageOfCumulativeChangesInOwnershipInterestOfSignificantShareholdersConsidered" substitutionGroup="xbrli:item"/>
<element name="PayrollTaxLiabilityCappedPerYear" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="avro_PayrollTaxLiabilityCappedPerYear" substitutionGroup="xbrli:item" xbrli:balance="credit"/>
<element name="TaxCreditCarryforwardsExpirationPeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_TaxCreditCarryforwardsExpirationPeriod" substitutionGroup="xbrli:item"/>
<element name="OrphanDrugCreditMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_OrphanDrugCreditMember" substitutionGroup="xbrli:item"/>
<element name="ExpirationThrough2033Member" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_ExpirationThrough2033Member" substitutionGroup="xbrli:item"/>
<element name="ExpirationThrough2039Member" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_ExpirationThrough2039Member" substitutionGroup="xbrli:item"/>
<element name="EffectiveIncomeTaxRateReconciliationChangeIndeferredTrueUps1" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_EffectiveIncomeTaxRateReconciliationChangeIndeferredTrueUps1" substitutionGroup="xbrli:item"/>
<element name="Effectiveincometaxratereconciliationchangeinstateratechanges1" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_Effectiveincometaxratereconciliationchangeinstateratechanges1" substitutionGroup="xbrli:item"/>
<element name="Effectiveincometaxratereconciliationchangeinstock1" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_Effectiveincometaxratereconciliationchangeinstock1" substitutionGroup="xbrli:item"/>
<element name="EffectiveIncomeTaxRateReconciliationPermanentDifference" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_EffectiveIncomeTaxRateReconciliationPermanentDifference" substitutionGroup="xbrli:item"/>
<element name="DeferredTaxAssetsCapitalizedStartUpAndOrganizationalCosts" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="avro_DeferredTaxAssetsCapitalizedStartUpAndOrganizationalCosts" substitutionGroup="xbrli:item" xbrli:balance="debit"/>
<element name="DeferredTaxAssetsLicenseAgreement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="avro_DeferredTaxAssetsLicenseAgreement" substitutionGroup="xbrli:item" xbrli:balance="debit"/>
<element name="LeaseLiability" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="avro_LeaseLiability" substitutionGroup="xbrli:item" xbrli:balance="credit"/>
<element name="DeferredIncomesTaxLiabilitiesNet" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="avro_DeferredIncomesTaxLiabilitiesNet" substitutionGroup="xbrli:item" xbrli:balance="credit"/>
<element name="DeferredTaxLiabilitiesRightOfUseAsset" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="avro_DeferredTaxLiabilitiesRightOfUseAsset" substitutionGroup="xbrli:item" xbrli:balance="debit"/>
<element name="TotalDeferredTaxLiabilities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="avro_TotalDeferredTaxLiabilities" substitutionGroup="xbrli:item" xbrli:balance="credit"/>
<element name="EmployeeStockPurchaseProgram" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_EmployeeStockPurchaseProgram" substitutionGroup="xbrli:item"/>
<element name="OptionsToPurchaseCommonShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_OptionsToPurchaseCommonShares" substitutionGroup="xbrli:item"/>
<element name="UnvestedRestrictedStockAwardsAndUnits" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_UnvestedRestrictedStockAwardsAndUnits" substitutionGroup="xbrli:item"/>
<element name="WeightedAverageCommonShareOutstandingBasic" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_WeightedAverageCommonShareOutstandingBasic" substitutionGroup="xbrli:item"/>
<element name="WeightedAverageCommonShareOutstandingDiluted" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_WeightedAverageCommonShareOutstandingDiluted" substitutionGroup="xbrli:item"/>
<element name="RestrictedStockAwardsAndUnitsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_RestrictedStockAwardsAndUnitsMember" substitutionGroup="xbrli:item"/>
<element name="StockPurchaseAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_StockPurchaseAgreementMember" substitutionGroup="xbrli:item"/>
<element name="ProvisionForMaximumCashPayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_ProvisionForMaximumCashPayment" substitutionGroup="xbrli:item" xbrli:balance="debit"/>
<element name="OfficersAndBoardMembersMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_OfficersAndBoardMembersMember" substitutionGroup="xbrli:item"/>
<element name="LicenseAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_LicenseAgreementMember" substitutionGroup="xbrli:item"/>
<element name="SubleaseAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_SubleaseAgreementMember" substitutionGroup="xbrli:item"/>
<element name="DecemberTwoThousandTwentyThreeWorkforceReductionMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_DecemberTwoThousandTwentyThreeWorkforceReductionMember" substitutionGroup="xbrli:item"/>
<element name="EmployeeSeveranceAndOtherBenefitMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_EmployeeSeveranceAndOtherBenefitMember" substitutionGroup="xbrli:item"/>
<element name="JulyTwoThousandTwentyThreeWorkforceReductionMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_JulyTwoThousandTwentyThreeWorkforceReductionMember" substitutionGroup="xbrli:item"/>
<element name="CompanyWorkforceReduction" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="avro_CompanyWorkforceReduction" substitutionGroup="xbrli:item"/>
<element name="ExpenseRelatedToEmployeeBenefits" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="avro_ExpenseRelatedToEmployeeBenefits" substitutionGroup="xbrli:item" xbrli:balance="debit"/>
<element name="OutstandingRestructuringLiabilities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="avro_OutstandingRestructuringLiabilities" substitutionGroup="xbrli:item" xbrli:balance="credit"/>
<element name="BoardOfDirectorChairmanMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="avro_BoardOfDirectorChairmanMember" substitutionGroup="xbrli:item"/>
<element name="TerminationFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="avro_TerminationFee" substitutionGroup="xbrli:item" xbrli:balance="credit"/>
<element name="TerminationFeeToBePaid" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="avro_TerminationFeeToBePaid" substitutionGroup="xbrli:item" xbrli:balance="debit"/>
</schema>

1 Subsequent Filing that References this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 4/15/24  AVROBIO, Inc.                     S-4/A                 91:17M                                    Donnelley … Solutions/FA

19 Previous Filings that this Filing References

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 2/14/24  AVROBIO, Inc.                     S-4                   91:25M                                    Donnelley … Solutions/FA
 8/10/23  AVROBIO, Inc.                     10-Q        6/30/23   69:9.5M                                   Donnelley … Solutions/FA
 3/23/23  AVROBIO, Inc.                     10-K       12/31/22   82:10M                                    Donnelley … Solutions/FA
 8/09/22  AVROBIO, Inc.                     10-Q        6/30/22   65:7.3M                                   Donnelley … Solutions/FA
 6/10/22  AVROBIO, Inc.                     8-K:5,9     6/08/22   11:205K                                   ActiveDisclosure/FA
 3/17/22  AVROBIO, Inc.                     10-K       12/31/21   78:9.1M                                   ActiveDisclosure/FA
 5/13/21  AVROBIO, Inc.                     10-Q        3/31/21   62:5.3M                                   ActiveDisclosure/FA
 3/18/21  AVROBIO, Inc.                     10-K       12/31/20   73:9.1M                                   ActiveDisclosure/FA
11/05/20  AVROBIO, Inc.                     10-Q        9/30/20   61:6.1M                                   ActiveDisclosure/FA
 6/09/20  AVROBIO, Inc.                     8-K:5,9     6/04/20    2:66K                                    ActiveDisclosure/FA
 3/16/20  AVROBIO, Inc.                     10-K       12/31/19   85:8.4M                                   ActiveDisclosure/FA
12/20/19  AVROBIO, Inc.                     S-8        12/20/19    4:170K                                   Donnelley … Solutions/FA
 3/25/19  AVROBIO, Inc.                     S-8         3/25/19    4:96K                                    Donnelley … Solutions/FA
 3/25/19  AVROBIO, Inc.                     10-K       12/31/18   85:7.2M                                   Donnelley … Solutions/FA
12/21/18  AVROBIO, Inc.                     8-K:5,7,9  12/17/18    3:177K                                   Donnelley … Solutions/FA
 6/25/18  AVROBIO, Inc.                     8-K:5,9     6/20/18    3:148K                                   Donnelley … Solutions/FA
 6/11/18  AVROBIO, Inc.                     S-1/A¶                18:5.4M                                   Donnelley … Solutions/FA
 6/01/18  AVROBIO, Inc.                     S-1/A                  3:497K                                   Donnelley … Solutions/FA
 5/25/18  AVROBIO, Inc.                     S-1                   15:5.5M                                   Donnelley … Solutions/FA
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Filing Submission 0001193125-24-076669   –   Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)
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