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Ionis Pharmaceuticals Inc. – ‘8-K’ for 2/28/24 – ‘XML’

On:  Thursday, 2/29/24, at 9:10am ET   ·   For:  2/28/24   ·   Accession #:  1140361-24-10288   ·   File #:  0-19125

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  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 2/29/24  Ionis Pharmaceuticals Inc.        8-K:1,5,9   2/28/24   10:156K                                   Broadridge Fin’l So… Inc

Current Report   —   Form 8-K

Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 8-K         Current Report                                      HTML     29K 
 5: R1          Document and Entity Information                     HTML     45K 
 7: XML         IDEA XML File -- Filing Summary                      XML     11K 
10: XML         XBRL Instance -- ef20022767_8k_htm                   XML     15K 
 6: EXCEL       IDEA Workbook of Financial Report Info              XLSX      8K 
 3: EX-101.LAB  XBRL Labels -- ions-20240228_lab                     XML     63K 
 4: EX-101.PRE  XBRL Presentations -- ions-20240228_pre              XML     45K 
 2: EX-101.SCH  XBRL Schema -- ions-20240228                         XSD     14K 
 8: JSON        XBRL Instance as JSON Data -- MetaLinks               13±    20K 
 9: ZIP         XBRL Zipped Folder -- 0001140361-24-010288-xbrl      Zip     14K 


‘XML’   —   XBRL Instance — ef20022767_8k_htm


This Document is an XBRL File.


                                                                                                                                                                                
<?xml version="1.0" encoding="windows-1252"?>
<xbrl xmlns="http://www.xbrl.org/2003/instance" xmlns:dei="http://xbrl.sec.gov/dei/2023" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink">
<link:schemaRef xlink:href="ions-20240228.xsd" xlink:type="simple"/>
<context id="c20240228to20240228">
<entity>
<identifier scheme="http://www.sec.gov/CIK"> 0000874015 </identifier>
</entity>
<period>
<startDate> 2024-02-28 </startDate>
<endDate> 2024-02-28 </endDate>
</period>
</context>
<dei:AmendmentFlag contextRef="c20240228to20240228" id="Fact_ec55fb31fd1d44558447658956a6469b"> false </dei:AmendmentFlag>
<dei:EntityCentralIndexKey contextRef="c20240228to20240228" id="Fact_6a92fc63a24f46379faff5164451dff3"> 0000874015 </dei:EntityCentralIndexKey>
<dei:DocumentType contextRef="c20240228to20240228" id="Fact_264e3e209a224ac69d86c6c847d5896c"> 8-K </dei:DocumentType>
<dei:DocumentPeriodEndDate contextRef="c20240228to20240228" id="Fact_d55812b82b9f47d08e4a8c220aa5b8f9"> 2024-02-28 </dei:DocumentPeriodEndDate>
<dei:EntityRegistrantName contextRef="c20240228to20240228" id="Fact_35fa0494691649b49daffffa3717c6fd"> IONIS PHARMACEUTICALS, INC. </dei:EntityRegistrantName>
<dei:EntityIncorporationStateCountryCode contextRef="c20240228to20240228" id="Fact_93d89aa516f041acb9954b8a1310711d"> DE </dei:EntityIncorporationStateCountryCode>
<dei:EntityFileNumber contextRef="c20240228to20240228" id="Fact_e949f2c1cbd54bc6869ac60b26092824"> 000-19125 </dei:EntityFileNumber>
<dei:EntityTaxIdentificationNumber contextRef="c20240228to20240228" id="Fact_3a2dc7e2a7794dccb02ec28920328530"> 33-0336973 </dei:EntityTaxIdentificationNumber>
<dei:EntityAddressAddressLine1 contextRef="c20240228to20240228" id="Fact_80398ff54f5146d285ffcd30f7da5ff4"> 2855 Gazelle Court </dei:EntityAddressAddressLine1>
<dei:EntityAddressCityOrTown contextRef="c20240228to20240228" id="Fact_d0ebc08678924f53a02a8b3795e0187e"> Carlsbad </dei:EntityAddressCityOrTown>
<dei:EntityAddressStateOrProvince contextRef="c20240228to20240228" id="Fact_606667751016410f99dcae7686ff8d45"> CA </dei:EntityAddressStateOrProvince>
<dei:EntityAddressPostalZipCode contextRef="c20240228to20240228" id="Fact_a8b8419f430e47f5b0801501524ed606"> 92010 </dei:EntityAddressPostalZipCode>
<dei:CityAreaCode contextRef="c20240228to20240228" id="Fact_abd7a3cdc662496a932416cd08d2b892"> 760 </dei:CityAreaCode>
<dei:LocalPhoneNumber contextRef="c20240228to20240228" id="Fact_6f7723e2e15e4f1988d4c892dceb977e"> 931-9200 </dei:LocalPhoneNumber>
<dei:WrittenCommunications contextRef="c20240228to20240228" id="Fact_7a7fe00b95ea4fdd934aadd811c1f2b2"> false </dei:WrittenCommunications>
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<dei:PreCommencementTenderOffer contextRef="c20240228to20240228" id="Fact_ac372ab5c81e46e2887eed8e0e7fcd36"> false </dei:PreCommencementTenderOffer>
<dei:PreCommencementIssuerTenderOffer contextRef="c20240228to20240228" id="Fact_f7f20cb38e4a43c59eb86bcd022fefd3"> false </dei:PreCommencementIssuerTenderOffer>
<dei:Security12bTitle contextRef="c20240228to20240228" id="Fact_8a1173149ecd4e3180d5b7adadf4b898"> Common Stock, $.001 Par Value </dei:Security12bTitle>
<dei:TradingSymbol contextRef="c20240228to20240228" id="Fact_39df7b54f7d74f3a876b81c9b01674ad"> IONS </dei:TradingSymbol>
<dei:SecurityExchangeName contextRef="c20240228to20240228" id="Fact_633d52228a824d8780205a8088e637eb"> NASDAQ </dei:SecurityExchangeName>
<dei:EntityEmergingGrowthCompany contextRef="c20240228to20240228" id="Fact_deabdee1191949efaec34cb81be450be"> false </dei:EntityEmergingGrowthCompany>
</xbrl>

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Filing Submission 0001140361-24-010288   –   Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)

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