SEC Info℠  
    Home      Search      My Interests      Help      Sign In      Please Sign In

Illumina, Inc. – ‘10-Q’ for 6/28/15 – ‘EX-101.DEF’

On:  Friday, 7/31/15, at 4:27pm ET   ·   For:  6/28/15   ·   Accession #:  1110803-15-140   ·   File #:  1-35406

Previous ‘10-Q’:  ‘10-Q’ on 5/1/15 for 3/29/15   ·   Next:  ‘10-Q’ on 11/2/15 for 9/27/15   ·   Latest:  ‘10-Q’ on 5/3/24 for 3/31/24   ·   4 References:   

Find Words in Filings emoji
 		  in    Show  and   ↓Hints

  As Of               Filer                 Filing    For·On·As Docs:Size

 7/31/15  Illumina, Inc.                    10-Q        6/28/15   56:5.4M

Quarterly Report   —   Form 10-Q   —   Sect. 13 / 15(d) – SEA’34
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-Q        Quarterly Report                                    HTML    414K 
 2: EX-10.1     Material Contract                                   HTML    277K 
 3: EX-31.1     CEO Certification Pursuant to Section 302 of the    HTML     28K 
                Sarbanes-Oxley Act                                               
 4: EX-31.2     CFO Certification Pursuant to Section 302 of the    HTML     26K 
                Sarbanes-Oxley Act                                               
 5: EX-32.1     CEO Certification Pursuant to 18 U.S.C Section      HTML     20K 
                1350                                                             
 6: EX-32.2     CFO Certification Pursuant to 18 U.S.C Section      HTML     20K 
                1350                                                             
35: R1          Document and Entity Information                     HTML     36K 
26: R2          Condensed Consolidated Balance Sheets (Unaudited)   HTML    100K 
33: R3          Condensed Consolidated Statements of Income         HTML     98K 
                (Unaudited)                                                      
37: R4          Condensed Consolidated Statements of Comprehensive  HTML     29K 
                Income (Unaudited)                                               
50: R5          Condensed Consolidated Statements of Cash Flows     HTML    136K 
                (Unaudited)                                                      
27: R6          Basis of Presentation and Summary of Significant    HTML     53K 
                Accounting Policies                                              
32: R7          Balance Sheet Account Details                       HTML    131K 
23: R8          Fair Value Measurements                             HTML     99K 
18: R9          Convertible Senior Notes                            HTML     62K 
51: R10         Share-based Compensation Expense                    HTML     52K 
39: R11         Stockholders' Equity                                HTML     71K 
38: R12         Income Taxes                                        HTML     24K 
43: R13         Legal Proceedings                                   HTML     23K 
44: R14         Basis of Presentation and Summary of Significant    HTML     58K 
                Accounting Policies (Policies)                                   
42: R15         Basis of Presentation and Summary of Significant    HTML     41K 
                Accounting Policies (Tables)                                     
45: R16         Balance Sheet Account Details (Tables)              HTML    129K 
34: R17         Fair Value Measurements (Tables)                    HTML     95K 
36: R18         Convertible Senior Notes (Tables)                   HTML     40K 
41: R19         Share-based Compensation Expense (Tables)           HTML     53K 
56: R20         Stockholders' Equity (Tables)                       HTML     58K 
47: R21         Basis of Presentation and Summary of Significant    HTML     39K 
                Accounting Policies (Details)                                    
29: R22         Basis of Presentation and Summary of Significant    HTML     19K 
                Accounting Policies (Details Textual)                            
40: R23         Balance Sheet Account Details (Details)             HTML     38K 
31: R24         Balance Sheet Account Details (Details 1)           HTML     28K 
16: R25         Balance Sheet Account Details (Details 2)           HTML     30K 
48: R26         Balance Sheet Account Details (Details 3)           HTML     44K 
52: R27         Balance Sheet Account Details (Details 4)           HTML     26K 
20: R28         Balance Sheet Account Details (Details 5)           HTML     26K 
19: R29         Balance Sheet Account Details (Details Textual)     HTML     44K 
21: R30         Fair Value Measurements (Details)                   HTML     72K 
22: R31         Fair Value Measurements (Details Textual)           HTML     29K 
24: R32         Convertible Senior Notes (Details)                  HTML     35K 
15: R33         Convertible Senior Notes (Details 1)                HTML     37K 
46: R34         Convertible Senior Notes (Details Textual)          HTML    104K 
28: R35         Share-based Compensation Expense (Details)          HTML     35K 
30: R36         Share-based Compensation Expense (Details 1)        HTML     39K 
17: R37         Share-based Compensation Expense (Details Textual)  HTML     22K 
55: R38         Stockholders' Equity (Details)                      HTML     52K 
13: R39         Stockholders' Equity (Details 1)                    HTML     34K 
25: R40         Stockholders' Equity (Details Textual)              HTML     53K 
49: R41         Income Taxes (Details Textual)                      HTML     23K 
53: XML         IDEA XML File -- Filing Summary                      XML     93K 
14: EXCEL       IDEA Workbook of Financial Reports                  XLSX     53K 
 7: EX-101.INS  XBRL Instance -- ilmn-20150628                       XML   1.28M 
 9: EX-101.CAL  XBRL Calculations -- ilmn-20150628_cal               XML    179K 
10: EX-101.DEF  XBRL Definitions -- ilmn-20150628_def                XML    275K 
11: EX-101.LAB  XBRL Labels -- ilmn-20150628_lab                     XML   1.04M 
12: EX-101.PRE  XBRL Presentations -- ilmn-20150628_pre              XML    556K 
 8: EX-101.SCH  XBRL Schema -- ilmn-20150628                         XSD     93K 
54: ZIP         XBRL Zipped Folder -- 0001110803-15-000140-xbrl      Zip    138K

‘EX-101.DEF’   —   XBRL Definitions — ilmn-20150628_def

This Exhibit is an XBRL XML File.

                                                                                                                                                                                
<?xml version="1.0" encoding="windows-1252"?>
<!-- XBRL Document Created with Wdesk from Workiva -->
<!-- -->
<linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns="http://www.xbrl.org/2003/linkbase" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<roleRef roleURI="http://www.illumina.com/role/BalanceSheetAccountDetails" xlink:href="ilmn-20150628.xsd#BalanceSheetAccountDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/BalanceSheetAccountDetailsDetails" xlink:href="ilmn-20150628.xsd#BalanceSheetAccountDetailsDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/BalanceSheetAccountDetailsDetails1" xlink:href="ilmn-20150628.xsd#BalanceSheetAccountDetailsDetails1" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/BalanceSheetAccountDetailsDetails2" xlink:href="ilmn-20150628.xsd#BalanceSheetAccountDetailsDetails2" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/BalanceSheetAccountDetailsDetails3" xlink:href="ilmn-20150628.xsd#BalanceSheetAccountDetailsDetails3" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/BalanceSheetAccountDetailsDetails4" xlink:href="ilmn-20150628.xsd#BalanceSheetAccountDetailsDetails4" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/BalanceSheetAccountDetailsDetails5" xlink:href="ilmn-20150628.xsd#BalanceSheetAccountDetailsDetails5" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/BalanceSheetAccountDetailsDetailsTextual" xlink:href="ilmn-20150628.xsd#BalanceSheetAccountDetailsDetailsTextual" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/BalanceSheetAccountDetailsTables" xlink:href="ilmn-20150628.xsd#BalanceSheetAccountDetailsTables" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/BasisOfPresentationAndSummaryOfSignificantAccountingPolicies" xlink:href="ilmn-20150628.xsd#BasisOfPresentationAndSummaryOfSignificantAccountingPolicies" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesDetails" xlink:href="ilmn-20150628.xsd#BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesDetailsTextual" xlink:href="ilmn-20150628.xsd#BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesDetailsTextual" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesPolicies" xlink:href="ilmn-20150628.xsd#BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesPolicies" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesTables" xlink:href="ilmn-20150628.xsd#BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesTables" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/CondensedConsolidatedBalanceSheetsUnaudited" xlink:href="ilmn-20150628.xsd#CondensedConsolidatedBalanceSheetsUnaudited" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/CondensedConsolidatedStatementsOfCashFlowsUnaudited" xlink:href="ilmn-20150628.xsd#CondensedConsolidatedStatementsOfCashFlowsUnaudited" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/CondensedConsolidatedStatementsOfComprehensiveIncomeUnaudited" xlink:href="ilmn-20150628.xsd#CondensedConsolidatedStatementsOfComprehensiveIncomeUnaudited" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/CondensedConsolidatedStatementsOfIncomeUnaudited" xlink:href="ilmn-20150628.xsd#CondensedConsolidatedStatementsOfIncomeUnaudited" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/ConvertibleSeniorNotes" xlink:href="ilmn-20150628.xsd#ConvertibleSeniorNotes" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/ConvertibleSeniorNotesDetails" xlink:href="ilmn-20150628.xsd#ConvertibleSeniorNotesDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/ConvertibleSeniorNotesDetails1" xlink:href="ilmn-20150628.xsd#ConvertibleSeniorNotesDetails1" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/ConvertibleSeniorNotesDetailsTextual" xlink:href="ilmn-20150628.xsd#ConvertibleSeniorNotesDetailsTextual" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/ConvertibleSeniorNotesTables" xlink:href="ilmn-20150628.xsd#ConvertibleSeniorNotesTables" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/DocumentAndEntityInformation" xlink:href="ilmn-20150628.xsd#DocumentAndEntityInformation" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/FairValueMeasurements" xlink:href="ilmn-20150628.xsd#FairValueMeasurements" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/FairValueMeasurementsDetails" xlink:href="ilmn-20150628.xsd#FairValueMeasurementsDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/FairValueMeasurementsDetailsTextual" xlink:href="ilmn-20150628.xsd#FairValueMeasurementsDetailsTextual" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/FairValueMeasurementsTables" xlink:href="ilmn-20150628.xsd#FairValueMeasurementsTables" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/IncomeTaxes" xlink:href="ilmn-20150628.xsd#IncomeTaxes" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/IncomeTaxesDetailsTextual" xlink:href="ilmn-20150628.xsd#IncomeTaxesDetailsTextual" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/LegalProceedings" xlink:href="ilmn-20150628.xsd#LegalProceedings" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/ShareBasedCompensationExpense" xlink:href="ilmn-20150628.xsd#ShareBasedCompensationExpense" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/ShareBasedCompensationExpenseDetails" xlink:href="ilmn-20150628.xsd#ShareBasedCompensationExpenseDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/ShareBasedCompensationExpenseDetails1" xlink:href="ilmn-20150628.xsd#ShareBasedCompensationExpenseDetails1" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/ShareBasedCompensationExpenseDetailsTextual" xlink:href="ilmn-20150628.xsd#ShareBasedCompensationExpenseDetailsTextual" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/ShareBasedCompensationExpenseTables" xlink:href="ilmn-20150628.xsd#ShareBasedCompensationExpenseTables" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/StockholdersEquity" xlink:href="ilmn-20150628.xsd#StockholdersEquity" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/StockholdersEquityDetails" xlink:href="ilmn-20150628.xsd#StockholdersEquityDetails" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/StockholdersEquityDetails1" xlink:href="ilmn-20150628.xsd#StockholdersEquityDetails1" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/StockholdersEquityDetailsTextual" xlink:href="ilmn-20150628.xsd#StockholdersEquityDetailsTextual" xlink:type="simple"/>
<roleRef roleURI="http://www.illumina.com/role/StockholdersEquityTables" xlink:href="ilmn-20150628.xsd#StockholdersEquityTables" xlink:type="simple"/>
<arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all" xlink:type="simple"/>
<arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default" xlink:type="simple"/>
<arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain" xlink:type="simple"/>
<arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member" xlink:type="simple"/>
<arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension" xlink:type="simple"/>
<definitionLink xlink:role="http://www.illumina.com/role/BalanceSheetAccountDetails" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/BalanceSheetAccountDetailsDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_DF97413B8D12608FA82BDFF91FEB9F86" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesTable" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_EBA65FC210E8B206AACCDFF91FEB1292" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_DF97413B8D12608FA82BDFF91FEB9F86" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_EBA65FC210E8B206AACCDFF91FEB1292" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_AF04011979386E85898CDFF91FEBCB10" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_EBA65FC210E8B206AACCDFF91FEB1292" xlink:to="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_AF04011979386E85898CDFF91FEBCB10" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_E4F7B7752EE11EC622EEDFF91FEBDDAA_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_AF04011979386E85898CDFF91FEBCB10" xlink:to="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_E4F7B7752EE11EC622EEDFF91FEBDDAA_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_E4F7B7752EE11EC622EEDFF91FEBDDAA" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_AF04011979386E85898CDFF91FEBCB10" xlink:to="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_E4F7B7752EE11EC622EEDFF91FEBDDAA" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_USGovernmentSponsoredEnterprisesDebtSecuritiesMember" xlink:label="loc_us-gaap_USGovernmentSponsoredEnterprisesDebtSecuritiesMember_2F4CB0ABBB340F503A95DFF91FEB52A0" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_E4F7B7752EE11EC622EEDFF91FEBDDAA" xlink:to="loc_us-gaap_USGovernmentSponsoredEnterprisesDebtSecuritiesMember_2F4CB0ABBB340F503A95DFF91FEB52A0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_CorporateDebtSecuritiesMember" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_0EB9F17F34A9ADDDC42CDFF91FEB8587" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_E4F7B7752EE11EC622EEDFF91FEBDDAA" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_0EB9F17F34A9ADDDC42CDFF91FEB8587" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_FFD3B9BAA871CFAC81ADDFF91FEBE3DC" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_E4F7B7752EE11EC622EEDFF91FEBDDAA" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_FFD3B9BAA871CFAC81ADDFF91FEBE3DC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShortTermInvestmentsAbstract" xlink:label="loc_us-gaap_ShortTermInvestmentsAbstract_DF701C67D15C4DD9D4D8DFF91FEB4B4B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_DF97413B8D12608FA82BDFF91FEB9F86" xlink:to="loc_us-gaap_ShortTermInvestmentsAbstract_DF701C67D15C4DD9D4D8DFF91FEB4B4B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAbstract" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAbstract_F7458666910DCD018BA9DFF91FEB15CD" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermInvestmentsAbstract_DF701C67D15C4DD9D4D8DFF91FEB4B4B" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAbstract_F7458666910DCD018BA9DFF91FEB15CD" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAmortizedCost" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_F2007B88933DE5F873B1DFF91FEB2740" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_F7458666910DCD018BA9DFF91FEB15CD" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_F2007B88933DE5F873B1DFF91FEB2740" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_DA514CFFA217052B75F1DFF91FEB336D" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_F7458666910DCD018BA9DFF91FEB15CD" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_DA514CFFA217052B75F1DFF91FEB336D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_DD083252DE3B5709F935DFF91FEB7264" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_F7458666910DCD018BA9DFF91FEB15CD" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_DD083252DE3B5709F935DFF91FEB7264" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_AEAA7DE036A804818696DFF91FEBD934" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_F7458666910DCD018BA9DFF91FEB15CD" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_AEAA7DE036A804818696DFF91FEBD934" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.illumina.com/role/BalanceSheetAccountDetailsDetails1" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/BalanceSheetAccountDetailsDetails2" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/BalanceSheetAccountDetailsDetails3" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/BalanceSheetAccountDetailsDetails4" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/BalanceSheetAccountDetailsDetails5" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/BalanceSheetAccountDetailsDetailsTextual" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_151C41B039769102A41CDB6A72069A0A" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_349610916F584E029F0CDB6A72068093" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_151C41B039769102A41CDB6A72069A0A" xlink:to="loc_us-gaap_StatementTable_349610916F584E029F0CDB6A72068093" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_085757C6551B20A341D3DB6A7206447F" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_349610916F584E029F0CDB6A72068093" xlink:to="loc_us-gaap_RangeAxis_085757C6551B20A341D3DB6A7206447F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_803227124B398986CA8EDB6A72066824_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RangeAxis_085757C6551B20A341D3DB6A7206447F" xlink:to="loc_us-gaap_RangeMember_803227124B398986CA8EDB6A72066824_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_803227124B398986CA8EDB6A72066824" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RangeAxis_085757C6551B20A341D3DB6A7206447F" xlink:to="loc_us-gaap_RangeMember_803227124B398986CA8EDB6A72066824" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_78E8DDD2EA7A3637ED6EDB6A7206EBE9" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RangeMember_803227124B398986CA8EDB6A72066824" xlink:to="loc_us-gaap_MinimumMember_78E8DDD2EA7A3637ED6EDB6A7206EBE9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_A49168BE852B5DD1ECA1DB6A7206CBDB" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RangeMember_803227124B398986CA8EDB6A72066824" xlink:to="loc_us-gaap_MaximumMember_A49168BE852B5DD1ECA1DB6A7206CBDB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_CostMethodInvestments" xlink:label="loc_us-gaap_CostMethodInvestments_B339B72F1D5D646411DFDB6A72069041" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_151C41B039769102A41CDB6A72069A0A" xlink:to="loc_us-gaap_CostMethodInvestments_B339B72F1D5D646411DFDB6A72069041" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_RevenueFromRelatedParties" xlink:label="loc_us-gaap_RevenueFromRelatedParties_A7D131C6CE5DCDC50AFBDB6A720671F0" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_151C41B039769102A41CDB6A72069A0A" xlink:to="loc_us-gaap_RevenueFromRelatedParties_A7D131C6CE5DCDC50AFBDB6A720671F0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_CostMethodInvestmentsRealizedGains" xlink:label="loc_us-gaap_CostMethodInvestmentsRealizedGains_0F96C2CB988FD8A5EDFDDB6A72060B9A" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_151C41B039769102A41CDB6A72069A0A" xlink:to="loc_us-gaap_CostMethodInvestmentsRealizedGains_0F96C2CB988FD8A5EDFDDB6A72060B9A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_DerivativeNotionalAmount" xlink:label="loc_invest_DerivativeNotionalAmount_0E0921C97188B939855FDB6A7206F964" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_151C41B039769102A41CDB6A72069A0A" xlink:to="loc_invest_DerivativeNotionalAmount_0E0921C97188B939855FDB6A7206F964" xlink:type="arc"/>
<loc xlink:href="ilmn-20150628.xsd#ilmn_InstrumentWarrantyPeriod" xlink:label="loc_ilmn_InstrumentWarrantyPeriod_8F2F1EFA2E459ECE888BDB6A7206EC3C" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_151C41B039769102A41CDB6A72069A0A" xlink:to="loc_ilmn_InstrumentWarrantyPeriod_8F2F1EFA2E459ECE888BDB6A7206EC3C" xlink:type="arc"/>
<loc xlink:href="ilmn-20150628.xsd#ilmn_WarrantyonConsumableSalesThroughtheExpirationDate" xlink:label="loc_ilmn_WarrantyonConsumableSalesThroughtheExpirationDate_D013FC610883AD4AB820DB6A7206F396" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_151C41B039769102A41CDB6A72069A0A" xlink:to="loc_ilmn_WarrantyonConsumableSalesThroughtheExpirationDate_D013FC610883AD4AB820DB6A7206F396" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_LesseeLeasingArrangementsOperatingLeasesTermOfContract" xlink:label="loc_us-gaap_LesseeLeasingArrangementsOperatingLeasesTermOfContract_5AC8C5453173468782D2DB6A72062D1B" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_151C41B039769102A41CDB6A72069A0A" xlink:to="loc_us-gaap_LesseeLeasingArrangementsOperatingLeasesTermOfContract_5AC8C5453173468782D2DB6A72062D1B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_4AD83E784415C0B2669FDB6A7206CC68" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_151C41B039769102A41CDB6A72069A0A" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_4AD83E784415C0B2669FDB6A7206CC68" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.illumina.com/role/BalanceSheetAccountDetailsTables" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/BasisOfPresentationAndSummaryOfSignificantAccountingPolicies" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesDetails" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesDetailsTextual" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesPolicies" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/BasisOfPresentationAndSummaryOfSignificantAccountingPoliciesTables" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/CondensedConsolidatedBalanceSheetsUnaudited" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/CondensedConsolidatedStatementsOfCashFlowsUnaudited" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/CondensedConsolidatedStatementsOfComprehensiveIncomeUnaudited" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/CondensedConsolidatedStatementsOfIncomeUnaudited" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/ConvertibleSeniorNotes" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/ConvertibleSeniorNotesDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ExtinguishmentOfDebtLineItems" xlink:label="loc_us-gaap_ExtinguishmentOfDebtLineItems_9FFCAE265251F16F5EDEDF82F94CE969" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ScheduleOfExtinguishmentOfDebtTable" xlink:label="loc_us-gaap_ScheduleOfExtinguishmentOfDebtTable_659113E990A76851C852DF82F94C92B4" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ExtinguishmentOfDebtLineItems_9FFCAE265251F16F5EDEDF82F94CE969" xlink:to="loc_us-gaap_ScheduleOfExtinguishmentOfDebtTable_659113E990A76851C852DF82F94C92B4" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_9DE516BCDD7419E54EC6DF82F94CDE56" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfExtinguishmentOfDebtTable_659113E990A76851C852DF82F94C92B4" xlink:to="loc_us-gaap_DebtInstrumentAxis_9DE516BCDD7419E54EC6DF82F94CDE56" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_396B8F41583694535E38DF82F94C8A11_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_9DE516BCDD7419E54EC6DF82F94CDE56" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_396B8F41583694535E38DF82F94C8A11_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_396B8F41583694535E38DF82F94C8A11" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_9DE516BCDD7419E54EC6DF82F94CDE56" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_396B8F41583694535E38DF82F94C8A11" xlink:type="arc"/>
<loc xlink:href="ilmn-20150628.xsd#ilmn_ConvertibleSeniorNotesDueTwoZeroOneSixMember" xlink:label="loc_ilmn_ConvertibleSeniorNotesDueTwoZeroOneSixMember_74C5D8409A0DD103A4BFDF82F94C1F77" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_396B8F41583694535E38DF82F94C8A11" xlink:to="loc_ilmn_ConvertibleSeniorNotesDueTwoZeroOneSixMember_74C5D8409A0DD103A4BFDF82F94C1F77" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_RepaymentsOfConvertibleDebt" xlink:label="loc_us-gaap_RepaymentsOfConvertibleDebt_187DD9CBF62C7792A5B4DF82F94CE05C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ExtinguishmentOfDebtLineItems_9FFCAE265251F16F5EDEDF82F94CE969" xlink:to="loc_us-gaap_RepaymentsOfConvertibleDebt_187DD9CBF62C7792A5B4DF82F94CE05C" xlink:type="arc"/>
<loc xlink:href="ilmn-20150628.xsd#ilmn_ConversionValueOverPrincipalAmountPaidInSharesOfCommonStock" xlink:label="loc_ilmn_ConversionValueOverPrincipalAmountPaidInSharesOfCommonStock_C27CC33612A09E7B3D75DF82F94D033B" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ExtinguishmentOfDebtLineItems_9FFCAE265251F16F5EDEDF82F94CE969" xlink:to="loc_ilmn_ConversionValueOverPrincipalAmountPaidInSharesOfCommonStock_C27CC33612A09E7B3D75DF82F94D033B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentConvertibleNumberOfEquityInstruments" xlink:label="loc_us-gaap_DebtInstrumentConvertibleNumberOfEquityInstruments_2A877C9BC8CDC4502354DF82F94D3C01" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ExtinguishmentOfDebtLineItems_9FFCAE265251F16F5EDEDF82F94CE969" xlink:to="loc_us-gaap_DebtInstrumentConvertibleNumberOfEquityInstruments_2A877C9BC8CDC4502354DF82F94D3C01" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_A85053C82F928F41CCE2DF82F94DA146" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ExtinguishmentOfDebtLineItems_9FFCAE265251F16F5EDEDF82F94CE969" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_A85053C82F928F41CCE2DF82F94DA146" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_FairValueInputsDiscountRate" xlink:label="loc_us-gaap_FairValueInputsDiscountRate_50EEFDB7512A6EBD3FB9DF82F94D9C7C" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ExtinguishmentOfDebtLineItems_9FFCAE265251F16F5EDEDF82F94CE969" xlink:to="loc_us-gaap_FairValueInputsDiscountRate_50EEFDB7512A6EBD3FB9DF82F94D9C7C" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.illumina.com/role/ConvertibleSeniorNotesDetails1" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_48ACF5D10AB3412380ADD1C865B49C57" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="loc_us-gaap_DebtInstrumentTable_100119067572F5E1C5C7D1C865B4107B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_48ACF5D10AB3412380ADD1C865B49C57" xlink:to="loc_us-gaap_DebtInstrumentTable_100119067572F5E1C5C7D1C865B4107B" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_A1E2E40704278EBD190BD1C865B4038F" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_100119067572F5E1C5C7D1C865B4107B" xlink:to="loc_us-gaap_DebtInstrumentAxis_A1E2E40704278EBD190BD1C865B4038F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_9F962FE4241AFDDD4504D1C865B4AD9F_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_A1E2E40704278EBD190BD1C865B4038F" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_9F962FE4241AFDDD4504D1C865B4AD9F_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_9F962FE4241AFDDD4504D1C865B4AD9F" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_A1E2E40704278EBD190BD1C865B4038F" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_9F962FE4241AFDDD4504D1C865B4AD9F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentsAbstract" xlink:label="loc_us-gaap_DebtInstrumentsAbstract_84AB32EE125A4BC4199AD1C865B46F2E" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_48ACF5D10AB3412380ADD1C865B49C57" xlink:to="loc_us-gaap_DebtInstrumentsAbstract_84AB32EE125A4BC4199AD1C865B46F2E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_6DAE5F63E89E99B6D1F7D1C865B4BD9B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_84AB32EE125A4BC4199AD1C865B46F2E" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_6DAE5F63E89E99B6D1F7D1C865B4BD9B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_BCEAE1D7F4366297F06DD1C865B4A0DB" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_84AB32EE125A4BC4199AD1C865B46F2E" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_BCEAE1D7F4366297F06DD1C865B4A0DB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtLongtermAndShorttermCombinedAmount" xlink:label="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_F531FBDC363F4A90F931D1C865B44100" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_84AB32EE125A4BC4199AD1C865B46F2E" xlink:to="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_F531FBDC363F4A90F931D1C865B44100" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ConvertibleDebtCurrent" xlink:label="loc_us-gaap_ConvertibleDebtCurrent_56C60B703A841B5073B9D1C865B47A95" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_84AB32EE125A4BC4199AD1C865B46F2E" xlink:to="loc_us-gaap_ConvertibleDebtCurrent_56C60B703A841B5073B9D1C865B47A95" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ConvertibleDebtNoncurrent" xlink:label="loc_us-gaap_ConvertibleDebtNoncurrent_2E66C5EC65D79A4C34ADD1C865B45EB0" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_84AB32EE125A4BC4199AD1C865B46F2E" xlink:to="loc_us-gaap_ConvertibleDebtNoncurrent_2E66C5EC65D79A4C34ADD1C865B45EB0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent" xlink:label="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_D8ECD54C38EFD894F85DD1C865B4FC24" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_84AB32EE125A4BC4199AD1C865B46F2E" xlink:to="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_D8ECD54C38EFD894F85DD1C865B4FC24" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_LongTermDebtFairValue" xlink:label="loc_us-gaap_LongTermDebtFairValue_4112AC096BFF4E73E122D1C865B49517" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_84AB32EE125A4BC4199AD1C865B46F2E" xlink:to="loc_us-gaap_LongTermDebtFairValue_4112AC096BFF4E73E122D1C865B49517" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentConvertibleRemainingDiscountAmortizationPeriod1" xlink:label="loc_us-gaap_DebtInstrumentConvertibleRemainingDiscountAmortizationPeriod1_F83B6CD7ABB1E08DE773D1C865B4CDDE" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentsAbstract_84AB32EE125A4BC4199AD1C865B46F2E" xlink:to="loc_us-gaap_DebtInstrumentConvertibleRemainingDiscountAmortizationPeriod1_F83B6CD7ABB1E08DE773D1C865B4CDDE" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.illumina.com/role/ConvertibleSeniorNotesDetailsTextual" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_94C21E894D88CEE03A9ADFEDAA176DE9" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="loc_us-gaap_DebtInstrumentTable_B5C30A4A80E49BFD222BDFEDAA17BD6B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_94C21E894D88CEE03A9ADFEDAA176DE9" xlink:to="loc_us-gaap_DebtInstrumentTable_B5C30A4A80E49BFD222BDFEDAA17BD6B" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_E8072A012D20CC0B41CBDFEDAA1786CF" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_B5C30A4A80E49BFD222BDFEDAA17BD6B" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_E8072A012D20CC0B41CBDFEDAA1786CF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_C086A464B9EB574FB0E4DFEDAA171A02_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_E8072A012D20CC0B41CBDFEDAA1786CF" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_C086A464B9EB574FB0E4DFEDAA171A02_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_C086A464B9EB574FB0E4DFEDAA171A02" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_E8072A012D20CC0B41CBDFEDAA1786CF" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_C086A464B9EB574FB0E4DFEDAA171A02" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_95F0C04033299D4F11BCDFEDAA173CB7" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_C086A464B9EB574FB0E4DFEDAA171A02" xlink:to="loc_us-gaap_SubsequentEventMember_95F0C04033299D4F11BCDFEDAA173CB7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_F91C2B0FE5E9298AFB7DDFEDAA170A35" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_B5C30A4A80E49BFD222BDFEDAA17BD6B" xlink:to="loc_us-gaap_DebtInstrumentAxis_F91C2B0FE5E9298AFB7DDFEDAA170A35" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_3825293B6A927042607EDFEDAA17F1D2_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_F91C2B0FE5E9298AFB7DDFEDAA170A35" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_3825293B6A927042607EDFEDAA17F1D2_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_3825293B6A927042607EDFEDAA17F1D2" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_F91C2B0FE5E9298AFB7DDFEDAA170A35" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_3825293B6A927042607EDFEDAA17F1D2" xlink:type="arc"/>
<loc xlink:href="ilmn-20150628.xsd#ilmn_ConvertibleSeniorNotesdueTwoZeroOneNineMember" xlink:label="loc_ilmn_ConvertibleSeniorNotesdueTwoZeroOneNineMember_5118BFED7FD4515E5F0BDFEDAA17DA83" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_3825293B6A927042607EDFEDAA17F1D2" xlink:to="loc_ilmn_ConvertibleSeniorNotesdueTwoZeroOneNineMember_5118BFED7FD4515E5F0BDFEDAA17DA83" xlink:type="arc"/>
<loc xlink:href="ilmn-20150628.xsd#ilmn_ConvertibleSeniorNotesdueTwoZeroTwoOneMember" xlink:label="loc_ilmn_ConvertibleSeniorNotesdueTwoZeroTwoOneMember_4277D126DB72020A65FEDFEDAA177B38" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_3825293B6A927042607EDFEDAA17F1D2" xlink:to="loc_ilmn_ConvertibleSeniorNotesdueTwoZeroTwoOneMember_4277D126DB72020A65FEDFEDAA177B38" xlink:type="arc"/>
<loc xlink:href="ilmn-20150628.xsd#ilmn_ConvertibleSeniorNotesdueTwoZeroOneNineandTwoZeroTwoOneMember" xlink:label="loc_ilmn_ConvertibleSeniorNotesdueTwoZeroOneNineandTwoZeroTwoOneMember_288F11C9C077B83D17B8DFEDAA172628" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_3825293B6A927042607EDFEDAA17F1D2" xlink:to="loc_ilmn_ConvertibleSeniorNotesdueTwoZeroOneNineandTwoZeroTwoOneMember_288F11C9C077B83D17B8DFEDAA172628" xlink:type="arc"/>
<loc xlink:href="ilmn-20150628.xsd#ilmn_ConvertibleSeniorNotesDueTwoZeroOneSixMember" xlink:label="loc_ilmn_ConvertibleSeniorNotesDueTwoZeroOneSixMember_6667AA93DB1B938A2044DFEDAA17A690" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_3825293B6A927042607EDFEDAA17F1D2" xlink:to="loc_ilmn_ConvertibleSeniorNotesDueTwoZeroOneSixMember_6667AA93DB1B938A2044DFEDAA17A690" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_55217E1D38FA18987D31DFEDAA17679C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_94C21E894D88CEE03A9ADFEDAA176DE9" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_55217E1D38FA18987D31DFEDAA17679C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_6E96EC0E21441C7AB6F4DFEDAA175895" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_94C21E894D88CEE03A9ADFEDAA176DE9" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_6E96EC0E21441C7AB6F4DFEDAA175895" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentMaturityDate" xlink:label="loc_us-gaap_DebtInstrumentMaturityDate_1A2CE3F047413F905B15DFEDAA17C5E1" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_94C21E894D88CEE03A9ADFEDAA176DE9" xlink:to="loc_us-gaap_DebtInstrumentMaturityDate_1A2CE3F047413F905B15DFEDAA17C5E1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_78C4F96A5F9BD6021C2DDFEDAA173518" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_94C21E894D88CEE03A9ADFEDAA176DE9" xlink:to="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_78C4F96A5F9BD6021C2DDFEDAA173518" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtLongtermAndShorttermCombinedAmount" xlink:label="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_BFFC7C9A3B1ACFAF2539DFEDAA17DF3A" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_94C21E894D88CEE03A9ADFEDAA176DE9" xlink:to="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_BFFC7C9A3B1ACFAF2539DFEDAA17DF3A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent" xlink:label="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_A72DF509FD9394911BC2DFEDAA17C36F" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_94C21E894D88CEE03A9ADFEDAA176DE9" xlink:to="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_A72DF509FD9394911BC2DFEDAA17C36F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ProceedsFromIssuanceOfDebt" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfDebt_AA9DE9C4C1DF6571DB17DFEDAA17EC4E" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_94C21E894D88CEE03A9ADFEDAA176DE9" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfDebt_AA9DE9C4C1DF6571DB17DFEDAA17EC4E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionRatio1" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_AE8D127A9AC5FA07A84DDFEDAA17E3B6" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_94C21E894D88CEE03A9ADFEDAA176DE9" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_AE8D127A9AC5FA07A84DDFEDAA17E3B6" xlink:type="arc"/>
<loc xlink:href="ilmn-20150628.xsd#ilmn_DifferenceBetweenDailyConversionValueAndDailyVwapToCalculateDailyShareAmount" xlink:label="loc_ilmn_DifferenceBetweenDailyConversionValueAndDailyVwapToCalculateDailyShareAmount_C977E76150041DD14108DFEDAA17C293" xlink:type="locator"/>
<definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_94C21E894D88CEE03A9ADFEDAA176DE9" xlink:to="loc_ilmn_DifferenceBetweenDailyConversionValueAndDailyVwapToCalculateDailyShareAmount_C977E76150041DD14108DFEDAA17C293" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionPrice1" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_10E249EB8B5ED324DB6BDFEDAA17ADE0" xlink:type="locator"/>
<definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_94C21E894D88CEE03A9ADFEDAA176DE9" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_10E249EB8B5ED324DB6BDFEDAA17ADE0" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentConvertibleTermsOfConversionFeature" xlink:label="loc_us-gaap_DebtInstrumentConvertibleTermsOfConversionFeature_6BD08BBF618EA3B3DC21DFEDAA174143" xlink:type="locator"/>
<definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_94C21E894D88CEE03A9ADFEDAA176DE9" xlink:to="loc_us-gaap_DebtInstrumentConvertibleTermsOfConversionFeature_6BD08BBF618EA3B3DC21DFEDAA174143" xlink:type="arc"/>
<loc xlink:href="ilmn-20150628.xsd#ilmn_NumberOfConsecutiveTradingDaysInMeasurementPeriod" xlink:label="loc_ilmn_NumberOfConsecutiveTradingDaysInMeasurementPeriod_2E0EC853DC8E34E16106DFEDAA17C1DB" xlink:type="locator"/>
<definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_94C21E894D88CEE03A9ADFEDAA176DE9" xlink:to="loc_ilmn_NumberOfConsecutiveTradingDaysInMeasurementPeriod_2E0EC853DC8E34E16106DFEDAA17C1DB" xlink:type="arc"/>
<loc xlink:href="ilmn-20150628.xsd#ilmn_ConversionTriggeringCommonStockTradingPriceAsPercentageOfPriceLastReportedInMeasurementPeriodConvertedAtConversionRate" xlink:label="loc_ilmn_ConversionTriggeringCommonStockTradingPriceAsPercentageOfPriceLastReportedInMeasurementPeriodConvertedAtConversionRate_925965C7CA1F56640BF5DFEDAA17642C" xlink:type="locator"/>
<definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_94C21E894D88CEE03A9ADFEDAA176DE9" xlink:to="loc_ilmn_ConversionTriggeringCommonStockTradingPriceAsPercentageOfPriceLastReportedInMeasurementPeriodConvertedAtConversionRate_925965C7CA1F56640BF5DFEDAA17642C" xlink:type="arc"/>
<loc xlink:href="ilmn-20150628.xsd#ilmn_Observationperiodfortheobservationvalue" xlink:label="loc_ilmn_Observationperiodfortheobservationvalue_79C81490F3920442326ADFEDAA171B63" xlink:type="locator"/>
<definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_94C21E894D88CEE03A9ADFEDAA176DE9" xlink:to="loc_ilmn_Observationperiodfortheobservationvalue_79C81490F3920442326ADFEDAA171B63" xlink:type="arc"/>
<loc xlink:href="ilmn-20150628.xsd#ilmn_NumberOfConsecutiveTradingDaysOnWhichTradingPriceIsExaminedForTriggeringOfConversion1" xlink:label="loc_ilmn_NumberOfConsecutiveTradingDaysOnWhichTradingPriceIsExaminedForTriggeringOfConversion1_B65F1B5B44ED3C0B74C6DFEDAA171B3D" xlink:type="locator"/>
<definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_94C21E894D88CEE03A9ADFEDAA176DE9" xlink:to="loc_ilmn_NumberOfConsecutiveTradingDaysOnWhichTradingPriceIsExaminedForTriggeringOfConversion1_B65F1B5B44ED3C0B74C6DFEDAA171B3D" xlink:type="arc"/>
<loc xlink:href="ilmn-20150628.xsd#ilmn_ConversionTriggeringCommonStockPriceAsPercentageOfApplicableConversionPriceInEffectOnLastTradingDayOfImmediatelyPrecedingCalendarQuarter" xlink:label="loc_ilmn_ConversionTriggeringCommonStockPriceAsPercentageOfApplicableConversionPriceInEffectOnLastTradingDayOfImmediatelyPrecedingCalendarQuarter_7F1BA3CCC24D7BE1BBA4DFEDAA27CCC3" xlink:type="locator"/>
<definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_94C21E894D88CEE03A9ADFEDAA176DE9" xlink:to="loc_ilmn_ConversionTriggeringCommonStockPriceAsPercentageOfApplicableConversionPriceInEffectOnLastTradingDayOfImmediatelyPrecedingCalendarQuarter_7F1BA3CCC24D7BE1BBA4DFEDAA27CCC3" xlink:type="arc"/>
<loc xlink:href="ilmn-20150628.xsd#ilmn_Convertibleseniornoteconversionendperiod" xlink:label="loc_ilmn_Convertibleseniornoteconversionendperiod_C1D272BFD66746B13E4EDFEDAA2700A9" xlink:type="locator"/>
<definitionArc order="17" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_94C21E894D88CEE03A9ADFEDAA176DE9" xlink:to="loc_ilmn_Convertibleseniornoteconversionendperiod_C1D272BFD66746B13E4EDFEDAA2700A9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentRepurchasedFaceAmount" xlink:label="loc_us-gaap_DebtInstrumentRepurchasedFaceAmount_FC29E6419B9A7692A14FDFEDAA2766B4" xlink:type="locator"/>
<definitionArc order="18" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_94C21E894D88CEE03A9ADFEDAA176DE9" xlink:to="loc_us-gaap_DebtInstrumentRepurchasedFaceAmount_FC29E6419B9A7692A14FDFEDAA2766B4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_RepaymentsOfConvertibleDebt" xlink:label="loc_us-gaap_RepaymentsOfConvertibleDebt_41B91CDCA0EA6DF6AC3FDFEDAA279A86" xlink:type="locator"/>
<definitionArc order="19" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_94C21E894D88CEE03A9ADFEDAA176DE9" xlink:to="loc_us-gaap_RepaymentsOfConvertibleDebt_41B91CDCA0EA6DF6AC3FDFEDAA279A86" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_F17463B9156034CC0A35DFEDAA27D970" xlink:type="locator"/>
<definitionArc order="20" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_94C21E894D88CEE03A9ADFEDAA176DE9" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_F17463B9156034CC0A35DFEDAA27D970" xlink:type="arc"/>
<loc xlink:href="ilmn-20150628.xsd#ilmn_DebtInstrumentRepurchaseAmountDebtComponent" xlink:label="loc_ilmn_DebtInstrumentRepurchaseAmountDebtComponent_42BF5D7BF36F401FEE69DFEDAA2786F1" xlink:type="locator"/>
<definitionArc order="21" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_94C21E894D88CEE03A9ADFEDAA176DE9" xlink:to="loc_ilmn_DebtInstrumentRepurchaseAmountDebtComponent_42BF5D7BF36F401FEE69DFEDAA2786F1" xlink:type="arc"/>
<loc xlink:href="ilmn-20150628.xsd#ilmn_DebtInstrumentRepurchaseAmountEquityComponent" xlink:label="loc_ilmn_DebtInstrumentRepurchaseAmountEquityComponent_8E91782046F1A58B78F5DFEDAA279BDE" xlink:type="locator"/>
<definitionArc order="22" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_94C21E894D88CEE03A9ADFEDAA176DE9" xlink:to="loc_ilmn_DebtInstrumentRepurchaseAmountEquityComponent_8E91782046F1A58B78F5DFEDAA279BDE" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal" xlink:label="loc_us-gaap_DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal_D40AD68B18976F10C214DFEDAA271886" xlink:type="locator"/>
<definitionArc order="23" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_94C21E894D88CEE03A9ADFEDAA176DE9" xlink:to="loc_us-gaap_DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal_D40AD68B18976F10C214DFEDAA271886" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.illumina.com/role/ConvertibleSeniorNotesTables" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/DocumentAndEntityInformation" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/FairValueMeasurements" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/FairValueMeasurementsDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9A7E3377B106A9E3A6C0BD10E59C93C5" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_10DFB3E1C42200C5552CBD10E59C6435" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9A7E3377B106A9E3A6C0BD10E59C93C5" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_10DFB3E1C42200C5552CBD10E59C6435" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_46E3D6AA80110CF2B49EBD10E59C89FC" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_10DFB3E1C42200C5552CBD10E59C6435" xlink:to="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_46E3D6AA80110CF2B49EBD10E59C89FC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_06D2E964FAAAD15D2406BD10E59C86C2_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_46E3D6AA80110CF2B49EBD10E59C89FC" xlink:to="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_06D2E964FAAAD15D2406BD10E59C86C2_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_06D2E964FAAAD15D2406BD10E59C86C2" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_46E3D6AA80110CF2B49EBD10E59C89FC" xlink:to="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_06D2E964FAAAD15D2406BD10E59C86C2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_USGovernmentSponsoredEnterprisesDebtSecuritiesMember" xlink:label="loc_us-gaap_USGovernmentSponsoredEnterprisesDebtSecuritiesMember_D48B5B77B6437AC4E096BD10E59C435F" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_06D2E964FAAAD15D2406BD10E59C86C2" xlink:to="loc_us-gaap_USGovernmentSponsoredEnterprisesDebtSecuritiesMember_D48B5B77B6437AC4E096BD10E59C435F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_CorporateDebtSecuritiesMember" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_C97E1B0C7FC679AAB686BD10E59C9BF9" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_06D2E964FAAAD15D2406BD10E59C86C2" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_C97E1B0C7FC679AAB686BD10E59C9BF9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_61E06804B53DA9F577C5BD10E59C0374" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_06D2E964FAAAD15D2406BD10E59C86C2" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_61E06804B53DA9F577C5BD10E59C0374" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_98890FA32A5805F64DF5BD10E59C266E" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_10DFB3E1C42200C5552CBD10E59C6435" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_98890FA32A5805F64DF5BD10E59C266E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_DF8E1AC699D0739B9663BD10E59C8FA9_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_98890FA32A5805F64DF5BD10E59C266E" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_DF8E1AC699D0739B9663BD10E59C8FA9_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_DF8E1AC699D0739B9663BD10E59C8FA9" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_98890FA32A5805F64DF5BD10E59C266E" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_DF8E1AC699D0739B9663BD10E59C8FA9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_6793E3C63E59E8A3A307BD10E59CD3FC" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_DF8E1AC699D0739B9663BD10E59C8FA9" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_6793E3C63E59E8A3A307BD10E59CD3FC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_6D276435D264353C6526BD10E59C70C3" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_DF8E1AC699D0739B9663BD10E59C8FA9" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_6D276435D264353C6526BD10E59C70C3" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_A17F4141929641962C7FBD10E59CB778" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_DF8E1AC699D0739B9663BD10E59C8FA9" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_A17F4141929641962C7FBD10E59CB778" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_C18AD7AC1876D2C26372BD10E59C1DD5" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_10DFB3E1C42200C5552CBD10E59C6435" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_C18AD7AC1876D2C26372BD10E59C1DD5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_807266D0A81871E975DDBD10E59C250D_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_C18AD7AC1876D2C26372BD10E59C1DD5" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_807266D0A81871E975DDBD10E59C250D_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_807266D0A81871E975DDBD10E59C250D" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_C18AD7AC1876D2C26372BD10E59C1DD5" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_807266D0A81871E975DDBD10E59C250D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_42054024B072F68BD25FBD10E59C46F9" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_807266D0A81871E975DDBD10E59C250D" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_42054024B072F68BD25FBD10E59C46F9" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_AssetsFairValueDisclosureAbstract" xlink:label="loc_us-gaap_AssetsFairValueDisclosureAbstract_D32C08E51D1D1A159545BD10E59CE9A8" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9A7E3377B106A9E3A6C0BD10E59C93C5" xlink:to="loc_us-gaap_AssetsFairValueDisclosureAbstract_D32C08E51D1D1A159545BD10E59CE9A8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_CashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashEquivalentsAtCarryingValue_A55C0BE0102E530D3F47BD10E59CFD2E" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_D32C08E51D1D1A159545BD10E59CE9A8" xlink:to="loc_us-gaap_CashEquivalentsAtCarryingValue_A55C0BE0102E530D3F47BD10E59CFD2E" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_InvestmentsFairValueDisclosure" xlink:label="loc_us-gaap_InvestmentsFairValueDisclosure_25FF5B48416B3125F850BD10E59C1D5B" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_D32C08E51D1D1A159545BD10E59CE9A8" xlink:to="loc_us-gaap_InvestmentsFairValueDisclosure_25FF5B48416B3125F850BD10E59C1D5B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DeferredCompensationPlanAssets" xlink:label="loc_us-gaap_DeferredCompensationPlanAssets_44274873397A27B21350BD10E59C2A46" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_D32C08E51D1D1A159545BD10E59CE9A8" xlink:to="loc_us-gaap_DeferredCompensationPlanAssets_44274873397A27B21350BD10E59C2A46" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_AssetsFairValueDisclosure" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_E5B4455AB469439F2382BD10E59C828C" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_D32C08E51D1D1A159545BD10E59CE9A8" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_E5B4455AB469439F2382BD10E59C828C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosureAbstract" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_C938D8534B4CBF5340CDBD10E59C2D75" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9A7E3377B106A9E3A6C0BD10E59C93C5" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_C938D8534B4CBF5340CDBD10E59C2D75" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_F0BB6B049F38E22C8A55BD10E59CB0C2" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_C938D8534B4CBF5340CDBD10E59C2D75" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_F0BB6B049F38E22C8A55BD10E59CB0C2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_DeferredCompensationCashbasedArrangementsLiabilityCurrentAndNoncurrent" xlink:label="loc_us-gaap_DeferredCompensationCashbasedArrangementsLiabilityCurrentAndNoncurrent_ADA202421C0F866FADA3BD10E59C9E21" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_C938D8534B4CBF5340CDBD10E59C2D75" xlink:to="loc_us-gaap_DeferredCompensationCashbasedArrangementsLiabilityCurrentAndNoncurrent_ADA202421C0F866FADA3BD10E59C9E21" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosure" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_079AB83292D4BB7E4FC4BD10E59CADF6" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_C938D8534B4CBF5340CDBD10E59C2D75" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosure_079AB83292D4BB7E4FC4BD10E59CADF6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_77FA711100B8553935AEBD10E59C3792" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9A7E3377B106A9E3A6C0BD10E59C93C5" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_77FA711100B8553935AEBD10E59C3792" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_45D2FBC5DE1912A25724BD10E59CF837" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_77FA711100B8553935AEBD10E59C3792" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_45D2FBC5DE1912A25724BD10E59CF837" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.illumina.com/role/FairValueMeasurementsDetailsTextual" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_4D4D3DC11C79055B31AE6ED451A7128A" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_228818C91B9CC453318B6ED4519F35CC" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_4D4D3DC11C79055B31AE6ED451A7128A" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_228818C91B9CC453318B6ED4519F35CC" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_2BD99115D9CDCB09109F6ED451A0104F" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_228818C91B9CC453318B6ED4519F35CC" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_2BD99115D9CDCB09109F6ED451A0104F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_22DA2C85734A5FBC51406ED451A5738A_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_2BD99115D9CDCB09109F6ED451A0104F" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_22DA2C85734A5FBC51406ED451A5738A_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_22DA2C85734A5FBC51406ED451A5738A" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_2BD99115D9CDCB09109F6ED451A0104F" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_22DA2C85734A5FBC51406ED451A5738A" xlink:type="arc"/>
<loc xlink:href="ilmn-20150628.xsd#ilmn_VerinataMember" xlink:label="loc_ilmn_VerinataMember_63B9B0C5AEC5801D1D056ED451A68D3F" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_22DA2C85734A5FBC51406ED451A5738A" xlink:to="loc_ilmn_VerinataMember_63B9B0C5AEC5801D1D056ED451A68D3F" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_8ADC513F1E98E1FF69126ED451A6B554" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_228818C91B9CC453318B6ED4519F35CC" xlink:to="loc_us-gaap_RangeAxis_8ADC513F1E98E1FF69126ED451A6B554" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_80C90E01324A1DF6870C6ED451A68540_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RangeAxis_8ADC513F1E98E1FF69126ED451A6B554" xlink:to="loc_us-gaap_RangeMember_80C90E01324A1DF6870C6ED451A68540_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_80C90E01324A1DF6870C6ED451A68540" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RangeAxis_8ADC513F1E98E1FF69126ED451A6B554" xlink:to="loc_us-gaap_RangeMember_80C90E01324A1DF6870C6ED451A68540" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_CCE20DC8B9F1DA0684526ED451A6C21C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RangeMember_80C90E01324A1DF6870C6ED451A68540" xlink:to="loc_us-gaap_MaximumMember_CCE20DC8B9F1DA0684526ED451A6C21C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_CA64FD5F4099A7D466766ED451A709CF" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RangeMember_80C90E01324A1DF6870C6ED451A68540" xlink:to="loc_us-gaap_MinimumMember_CA64FD5F4099A7D466766ED451A709CF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_FairValueInputsDiscountRate" xlink:label="loc_us-gaap_FairValueInputsDiscountRate_5A44BA563F56F0FDCB546ED451A76ABE" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_4D4D3DC11C79055B31AE6ED451A7128A" xlink:to="loc_us-gaap_FairValueInputsDiscountRate_5A44BA563F56F0FDCB546ED451A76ABE" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_FairValueAssumptionsExpectedVolatilityRate" xlink:label="loc_us-gaap_FairValueAssumptionsExpectedVolatilityRate_61B8EFEFEAD18D8FFA246ED451A7B5DD" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_4D4D3DC11C79055B31AE6ED451A7128A" xlink:to="loc_us-gaap_FairValueAssumptionsExpectedVolatilityRate_61B8EFEFEAD18D8FFA246ED451A7B5DD" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_FairValueAssumptionsRiskFreeInterestRate" xlink:label="loc_us-gaap_FairValueAssumptionsRiskFreeInterestRate_B436C1887C805BAD570A6ED451A7A219" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_4D4D3DC11C79055B31AE6ED451A7128A" xlink:to="loc_us-gaap_FairValueAssumptionsRiskFreeInterestRate_B436C1887C805BAD570A6ED451A7A219" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.illumina.com/role/FairValueMeasurementsTables" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/IncomeTaxes" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/IncomeTaxesDetailsTextual" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/LegalProceedings" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/ShareBasedCompensationExpense" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/ShareBasedCompensationExpenseDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CAE82F15967ACF3815CD117C6904AE3D" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_29688C5FFE0AD4CC01E7117C69042C90" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CAE82F15967ACF3815CD117C6904AE3D" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_29688C5FFE0AD4CC01E7117C69042C90" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_275E325841F4AC5A7525117C690410A5" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_29688C5FFE0AD4CC01E7117C69042C90" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_275E325841F4AC5A7525117C690410A5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_305CBA35D314CA0BB58D117C690464BA_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_275E325841F4AC5A7525117C690410A5" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_305CBA35D314CA0BB58D117C690464BA_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_305CBA35D314CA0BB58D117C690464BA" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_275E325841F4AC5A7525117C690410A5" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_305CBA35D314CA0BB58D117C690464BA" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_CostOfSalesMember" xlink:label="loc_us-gaap_CostOfSalesMember_8FEAF43F8F35A684F124117C69040FB6" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_305CBA35D314CA0BB58D117C690464BA" xlink:to="loc_us-gaap_CostOfSalesMember_8FEAF43F8F35A684F124117C69040FB6" xlink:type="arc"/>
<loc xlink:href="ilmn-20150628.xsd#ilmn_CostOfServiceAndOtherRevenueMember" xlink:label="loc_ilmn_CostOfServiceAndOtherRevenueMember_4FC24682D10258B59A7B117C6904D1D8" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_305CBA35D314CA0BB58D117C690464BA" xlink:to="loc_ilmn_CostOfServiceAndOtherRevenueMember_4FC24682D10258B59A7B117C6904D1D8" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ResearchAndDevelopmentExpenseMember" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_3E1A03EAF0E53C99E51A117C690405A7" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_305CBA35D314CA0BB58D117C690464BA" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_3E1A03EAF0E53C99E51A117C690405A7" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_00BA59B25C7AC0E6229F117C69048BDF" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_305CBA35D314CA0BB58D117C690464BA" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_00BA59B25C7AC0E6229F117C69048BDF" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationAbstract" xlink:label="loc_us-gaap_ShareBasedCompensationAbstract_AEBCD196691104D4C90A117C69046C4B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CAE82F15967ACF3815CD117C6904AE3D" xlink:to="loc_us-gaap_ShareBasedCompensationAbstract_AEBCD196691104D4C90A117C69046C4B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_45EBBD6D8C941D0B7FC8117C69049498" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationAbstract_AEBCD196691104D4C90A117C69046C4B" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_45EBBD6D8C941D0B7FC8117C69049498" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_2FF1FB2E6F7074F3D465117C69045F36" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationAbstract_AEBCD196691104D4C90A117C69046C4B" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_2FF1FB2E6F7074F3D465117C69045F36" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_A2A5C5E66793ECFBCC22117C6904BC30" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationAbstract_AEBCD196691104D4C90A117C69046C4B" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_A2A5C5E66793ECFBCC22117C6904BC30" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.illumina.com/role/ShareBasedCompensationExpenseDetails1" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_B350971D5B8B4FC9CE40BD10E57C6AFA" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_B0ACF5887D6252D2BE73BD10E57C8C79" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_B350971D5B8B4FC9CE40BD10E57C6AFA" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_B0ACF5887D6252D2BE73BD10E57C8C79" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_7D2B15BEFA6A4A88D637BD10E57C0976" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_B0ACF5887D6252D2BE73BD10E57C8C79" xlink:to="loc_us-gaap_AwardTypeAxis_7D2B15BEFA6A4A88D637BD10E57C0976" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_1D855EFF5207847AA86CBD10E57C6B93_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_7D2B15BEFA6A4A88D637BD10E57C0976" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_1D855EFF5207847AA86CBD10E57C6B93_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_1D855EFF5207847AA86CBD10E57C6B93" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_7D2B15BEFA6A4A88D637BD10E57C0976" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_1D855EFF5207847AA86CBD10E57C6B93" xlink:type="arc"/>
<loc xlink:href="ilmn-20150628.xsd#ilmn_EmployeeStockPurchaseRightsMember" xlink:label="loc_ilmn_EmployeeStockPurchaseRightsMember_B45D606FDA9C2D7AD91CBD10E57CB9B5" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_1D855EFF5207847AA86CBD10E57C6B93" xlink:to="loc_ilmn_EmployeeStockPurchaseRightsMember_B45D606FDA9C2D7AD91CBD10E57CB9B5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_2CC9BBCD566EA5D0E3E5BD10E57C3171" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_B0ACF5887D6252D2BE73BD10E57C8C79" xlink:to="loc_us-gaap_RangeAxis_2CC9BBCD566EA5D0E3E5BD10E57C3171" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_A6506DC12617F3CF63F9BD10E57CA84A_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RangeAxis_2CC9BBCD566EA5D0E3E5BD10E57C3171" xlink:to="loc_us-gaap_RangeMember_A6506DC12617F3CF63F9BD10E57CA84A_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_A6506DC12617F3CF63F9BD10E57CA84A" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RangeAxis_2CC9BBCD566EA5D0E3E5BD10E57C3171" xlink:to="loc_us-gaap_RangeMember_A6506DC12617F3CF63F9BD10E57CA84A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_97D2C712BE7EE5E7B153BD10E57C86B5" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RangeMember_A6506DC12617F3CF63F9BD10E57CA84A" xlink:to="loc_us-gaap_MinimumMember_97D2C712BE7EE5E7B153BD10E57C86B5" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_A742DB449C894A4A8557BD10E57C22FC" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RangeMember_A6506DC12617F3CF63F9BD10E57CA84A" xlink:to="loc_us-gaap_MaximumMember_A742DB449C894A4A8557BD10E57C22FC" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_E971080ECE8E00A74F56BD10E57C9746" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_B350971D5B8B4FC9CE40BD10E57C6AFA" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_E971080ECE8E00A74F56BD10E57C9746" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum_733ECDFA3553573D1739BD10E57C3D47" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_E971080ECE8E00A74F56BD10E57C9746" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum_733ECDFA3553573D1739BD10E57C3D47" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum_EEE639E7E5C7C75BE7CFBD10E57C6431" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_E971080ECE8E00A74F56BD10E57C9746" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum_EEE639E7E5C7C75BE7CFBD10E57C6431" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum_A16D01C0E522EACAD188BD10E57CD1BD" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_E971080ECE8E00A74F56BD10E57C9746" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum_A16D01C0E522EACAD188BD10E57CD1BD" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum_6635C229A8276EA7B771BD10E57C16DB" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_E971080ECE8E00A74F56BD10E57C9746" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum_6635C229A8276EA7B771BD10E57C16DB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_4D6C65D050AE6F52CA9CBD10E57C18D2" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_E971080ECE8E00A74F56BD10E57C9746" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_4D6C65D050AE6F52CA9CBD10E57C18D2" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_35DC038ED1137C5C2061BD10E57CAC75" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_E971080ECE8E00A74F56BD10E57C9746" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_35DC038ED1137C5C2061BD10E57CAC75" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_F4FA06413B80EECF296EBD10E57C7498" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_E971080ECE8E00A74F56BD10E57C9746" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_F4FA06413B80EECF296EBD10E57C7498" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.illumina.com/role/ShareBasedCompensationExpenseDetailsTextual" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/ShareBasedCompensationExpenseTables" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/StockholdersEquity" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/StockholdersEquityDetails" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_28C66DE0F8AA588A450ABD10E56D21E3" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_F06C67DF1CFAC07F8638BD10E56D2B9C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_28C66DE0F8AA588A450ABD10E56D21E3" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_F06C67DF1CFAC07F8638BD10E56D2B9C" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_9EBFD11C7A4E48CC1542BD10E56DCF1D" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_F06C67DF1CFAC07F8638BD10E56D2B9C" xlink:to="loc_us-gaap_AwardTypeAxis_9EBFD11C7A4E48CC1542BD10E56DCF1D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_F2694CC5F279A3F3E9C2BD10E56D2EC4_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_9EBFD11C7A4E48CC1542BD10E56DCF1D" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_F2694CC5F279A3F3E9C2BD10E56D2EC4_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_F2694CC5F279A3F3E9C2BD10E56D2EC4" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_9EBFD11C7A4E48CC1542BD10E56DCF1D" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_F2694CC5F279A3F3E9C2BD10E56D2EC4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_RestrictedStockMember" xlink:label="loc_us-gaap_RestrictedStockMember_7597BE6EED20F5959D7CBD10E56D472C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_F2694CC5F279A3F3E9C2BD10E56D2EC4" xlink:to="loc_us-gaap_RestrictedStockMember_7597BE6EED20F5959D7CBD10E56D472C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_RestrictedStockUnitsRSUMember" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_AA9CDCA677B5315512ABBD10E56D5CF4" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_F2694CC5F279A3F3E9C2BD10E56D2EC4" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_AA9CDCA677B5315512ABBD10E56D5CF4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_PerformanceSharesMember" xlink:label="loc_us-gaap_PerformanceSharesMember_AEC3359B5B0862264045BD10E56DCB3A" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_F2694CC5F279A3F3E9C2BD10E56D2EC4" xlink:to="loc_us-gaap_PerformanceSharesMember_AEC3359B5B0862264045BD10E56DCB3A" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_E1D37DCB1A42B91E3F92BD10E56D11B6" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_28C66DE0F8AA588A450ABD10E56D21E3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_E1D37DCB1A42B91E3F92BD10E56D11B6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_52A377201B8CF915DCB1BD10E56D0A56" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_28C66DE0F8AA588A450ABD10E56D21E3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_52A377201B8CF915DCB1BD10E56D0A56" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_29A2B33F4E5151202102BD10E56DFD47" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_28C66DE0F8AA588A450ABD10E56D21E3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_29A2B33F4E5151202102BD10E56DFD47" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_B5FD9667C26C135136F2BD10E56DE207" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_28C66DE0F8AA588A450ABD10E56D21E3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_B5FD9667C26C135136F2BD10E56DE207" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_7D3AA7133CCB17022A58BD10E56D4702" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_28C66DE0F8AA588A450ABD10E56D21E3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_7D3AA7133CCB17022A58BD10E56D4702" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_5C621CD52A35EBA52A8CBD10E56D4BF4" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_28C66DE0F8AA588A450ABD10E56D21E3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_5C621CD52A35EBA52A8CBD10E56D4BF4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_A19470C0D47888203D36BD10E56DACB1" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_28C66DE0F8AA588A450ABD10E56D21E3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_A19470C0D47888203D36BD10E56DACB1" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_15533C05DE33035AD417BD10E56DEC92" xlink:type="locator"/>
<definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_28C66DE0F8AA588A450ABD10E56D21E3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_15533C05DE33035AD417BD10E56DEC92" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.illumina.com/role/StockholdersEquityDetails1" xlink:type="extended"/>
<definitionLink xlink:role="http://www.illumina.com/role/StockholdersEquityDetailsTextual" xlink:type="extended">
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_B46DBC9F999A474F4AB1D743E687AE69" xlink:type="locator"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_CCB9A1129828EAEBCBFED743E687761E" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_B46DBC9F999A474F4AB1D743E687AE69" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_CCB9A1129828EAEBCBFED743E687761E" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareRepurchaseProgramAxis" xlink:label="loc_us-gaap_ShareRepurchaseProgramAxis_58298D591EE8855DB4A4D743E687E02B" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_CCB9A1129828EAEBCBFED743E687761E" xlink:to="loc_us-gaap_ShareRepurchaseProgramAxis_58298D591EE8855DB4A4D743E687E02B" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareRepurchaseProgramDomain" xlink:label="loc_us-gaap_ShareRepurchaseProgramDomain_7E8BC3F00CB3A0F1638BD743E687E98C_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_58298D591EE8855DB4A4D743E687E02B" xlink:to="loc_us-gaap_ShareRepurchaseProgramDomain_7E8BC3F00CB3A0F1638BD743E687E98C_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareRepurchaseProgramDomain" xlink:label="loc_us-gaap_ShareRepurchaseProgramDomain_7E8BC3F00CB3A0F1638BD743E687E98C" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_58298D591EE8855DB4A4D743E687E02B" xlink:to="loc_us-gaap_ShareRepurchaseProgramDomain_7E8BC3F00CB3A0F1638BD743E687E98C" xlink:type="arc"/>
<loc xlink:href="ilmn-20150628.xsd#ilmn_January302014StockRepurchaseProgramMember" xlink:label="loc_ilmn_January302014StockRepurchaseProgramMember_891C6DE0D1CF29BBAD1AD743E6872DD4" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareRepurchaseProgramDomain_7E8BC3F00CB3A0F1638BD743E687E98C" xlink:to="loc_ilmn_January302014StockRepurchaseProgramMember_891C6DE0D1CF29BBAD1AD743E6872DD4" xlink:type="arc"/>
<loc xlink:href="ilmn-20150628.xsd#ilmn_May12015StockRepurchasePlanMember" xlink:label="loc_ilmn_May12015StockRepurchasePlanMember_5D899A829A816442B954D743E68768DE" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareRepurchaseProgramDomain_7E8BC3F00CB3A0F1638BD743E687E98C" xlink:to="loc_ilmn_May12015StockRepurchasePlanMember_5D899A829A816442B954D743E68768DE" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_PlanNameAxis" xlink:label="loc_us-gaap_PlanNameAxis_5D3794EB7F88F4205862D743E6870AEA" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_CCB9A1129828EAEBCBFED743E687761E" xlink:to="loc_us-gaap_PlanNameAxis_5D3794EB7F88F4205862D743E6870AEA" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_PlanNameDomain" xlink:label="loc_us-gaap_PlanNameDomain_FDE66B13433C7167A4E2D743E6874F85_default" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_5D3794EB7F88F4205862D743E6870AEA" xlink:to="loc_us-gaap_PlanNameDomain_FDE66B13433C7167A4E2D743E6874F85_default" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_PlanNameDomain" xlink:label="loc_us-gaap_PlanNameDomain_FDE66B13433C7167A4E2D743E6874F85" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_5D3794EB7F88F4205862D743E6870AEA" xlink:to="loc_us-gaap_PlanNameDomain_FDE66B13433C7167A4E2D743E6874F85" xlink:type="arc"/>
<loc xlink:href="ilmn-20150628.xsd#ilmn_A2015StockPlanMember" xlink:label="loc_ilmn_A2015StockPlanMember_897B4890303C018B24DBD743E687530F" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_FDE66B13433C7167A4E2D743E6874F85" xlink:to="loc_ilmn_A2015StockPlanMember_897B4890303C018B24DBD743E687530F" xlink:type="arc"/>
<loc xlink:href="ilmn-20150628.xsd#ilmn_A2015Illuminaand2005SolexaStockPlansMember" xlink:label="loc_ilmn_A2015Illuminaand2005SolexaStockPlansMember_01D116E2E51D6963E1A4D743E6873214" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_FDE66B13433C7167A4E2D743E6874F85" xlink:to="loc_ilmn_A2015Illuminaand2005SolexaStockPlansMember_01D116E2E51D6963E1A4D743E6873214" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_EmployeeStockMember" xlink:label="loc_us-gaap_EmployeeStockMember_0BC929AC29F762C71C41D743E6877AA6" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_FDE66B13433C7167A4E2D743E6874F85" xlink:to="loc_us-gaap_EmployeeStockMember_0BC929AC29F762C71C41D743E6877AA6" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized_D34D8BE3DB4701CAEE71D743E68721ED" xlink:type="locator"/>
<definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_B46DBC9F999A474F4AB1D743E687AE69" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized_D34D8BE3DB4701CAEE71D743E68721ED" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_AA82C8965103937437F4D743E68794CD" xlink:type="locator"/>
<definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_B46DBC9F999A474F4AB1D743E687AE69" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_AA82C8965103937437F4D743E68794CD" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_FCA4B77FA928539F2805D743E6879AE4" xlink:type="locator"/>
<definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_B46DBC9F999A474F4AB1D743E687AE69" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_FCA4B77FA928539F2805D743E6879AE4" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_1DD1B2F358FF5B24F8A8D743E687C68D" xlink:type="locator"/>
<definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_B46DBC9F999A474F4AB1D743E687AE69" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_1DD1B2F358FF5B24F8A8D743E687C68D" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent_7798244786FB52CFCE15D743E687C06C" xlink:type="locator"/>
<definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_B46DBC9F999A474F4AB1D743E687AE69" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent_7798244786FB52CFCE15D743E687C06C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_5E0EDF120E23E4B7259BD743E6876C52" xlink:type="locator"/>
<definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_B46DBC9F999A474F4AB1D743E687AE69" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_5E0EDF120E23E4B7259BD743E6876C52" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_StockRepurchaseProgramAuthorizedAmount1" xlink:label="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_B7F50A47701EFDE7E977D743E68788BB" xlink:type="locator"/>
<definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_B46DBC9F999A474F4AB1D743E687AE69" xlink:to="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_B7F50A47701EFDE7E977D743E68788BB" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_TreasuryStockSharesAcquired" xlink:label="loc_us-gaap_TreasuryStockSharesAcquired_63D9E4E6E80AED646096D743E6877683" xlink:type="locator"/>
<definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_B46DBC9F999A474F4AB1D743E687AE69" xlink:to="loc_us-gaap_TreasuryStockSharesAcquired_63D9E4E6E80AED646096D743E6877683" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_B5DFF178158D5D74EFA7D743E687221C" xlink:type="locator"/>
<definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_B46DBC9F999A474F4AB1D743E687AE69" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_B5DFF178158D5D74EFA7D743E687221C" xlink:type="arc"/>
<loc xlink:href="http://xbrl.fasb.org/us-gaap/2014/elts/us-gaap-2014-01-31.xsd#us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1" xlink:label="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_5486E5D248F22E0A0A5ED743E68730E9" xlink:type="locator"/>
<definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_B46DBC9F999A474F4AB1D743E687AE69" xlink:to="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_5486E5D248F22E0A0A5ED743E68730E9" xlink:type="arc"/>
</definitionLink>
<definitionLink xlink:role="http://www.illumina.com/role/StockholdersEquityTables" xlink:type="extended"/>
</linkbase>

4 Subsequent Filings that Reference this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 2/16/24  Illumina, Inc.                    10-K       12/31/23  111:18M
 2/17/23  Illumina, Inc.                    10-K        1/01/23  108:17M
 2/18/22  Illumina, Inc.                    10-K        1/02/22  108:15M
 2/17/21  Illumina, Inc.                    10-K        1/03/21  102:13M
↑Top
Filing Submission 0001110803-15-000140   –   Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)
Copyright © 2024 Fran Finnegan & Company LLC – All Rights Reserved.
About — Privacy — Redactions — Help — Thu., May 16, 2:43:04.2am ET