SEC Info  
    Home      Search      My Interests      Help      Sign In      Please Sign In

Illumina, Inc. – ‘10-Q’ for 7/2/23 – ‘EX-101.CAL’

On:  Thursday, 8/10/23, at 4:38pm ET   ·   For:  7/2/23   ·   Accession #:  1110803-23-64   ·   File #:  1-35406

Previous ‘10-Q’:  ‘10-Q’ on 5/5/23 for 4/2/23   ·   Next:  ‘10-Q’ on 11/13/23 for 10/1/23   ·   Latest:  ‘10-Q’ on 5/3/24 for 3/31/24   ·   9 References:   

Find Words in Filings emoji
 
  in    Show  and   Hints

  As Of               Filer                 Filing    For·On·As Docs:Size

 8/10/23  Illumina, Inc.                    10-Q        7/02/23   73:8.1M

Quarterly Report   —   Form 10-Q

Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-Q        Quarterly Report                                    HTML   1.81M 
 2: EX-10.1     Material Contract                                   HTML    104K 
 3: EX-31.1     Certification -- §302 - SOA'02                      HTML     28K 
 4: EX-31.2     Certification -- §302 - SOA'02                      HTML     28K 
 5: EX-32.1     Certification -- §906 - SOA'02                      HTML     23K 
 6: EX-32.2     Certification -- §906 - SOA'02                      HTML     24K 
12: R1          Cover Page                                          HTML     73K 
13: R2          Condensed Consolidated Balance Sheets               HTML    122K 
14: R3          Condensed Consolidated Statements of Operations     HTML    120K 
15: R4          Condensed Consolidated Statements of Comprehensive  HTML     40K 
                Income (Loss)                                                    
16: R5          Condensed Consolidated Statements of Stockholders?  HTML    120K 
                Equity                                                           
17: R6          Condensed Consolidated Statements of Cash Flows     HTML    111K 
18: R7          Organization and Significant Accounting Policies    HTML     51K 
19: R8          Revenue                                             HTML     90K 
20: R9          Investments and Fair Value Measurements             HTML     94K 
21: R10         Debt                                                HTML     59K 
22: R11         Stockholders? Equity                                HTML     87K 
23: R12         Supplemental Balance Sheet Details                  HTML     90K 
24: R13         Legal Proceedings                                   HTML     33K 
25: R14         Income Taxes                                        HTML     29K 
26: R15         Segment Information                                 HTML     56K 
27: R16         Pay vs Performance Disclosure                       HTML     34K 
28: R17         Insider Trading Arrangements                        HTML     47K 
29: R18         Organization and Significant Accounting Policies    HTML     39K 
                (Policies)                                                       
30: R19         Organization and Significant Accounting Policies    HTML     40K 
                (Tables)                                                         
31: R20         Revenue (Tables)                                    HTML     84K 
32: R21         Investments and Fair Value Measurements (Tables)    HTML     90K 
33: R22         Debt (Tables)                                       HTML     44K 
34: R23         Stockholders? Equity (Tables)                       HTML    106K 
35: R24         Supplemental Balance Sheet Details (Tables)         HTML     90K 
36: R25         Segment Information (Tables)                        HTML     51K 
37: R26         Organization and Significant Accounting Policies -  HTML     37K 
                Summary of Calculation of Weighted Average Shares                
                used to Calculate Basic and Diluted Earnings Per                 
                Share (Details)                                                  
38: R27         Revenue - Disaggregation of Revenue (Details)       HTML     62K 
39: R28         Revenue - Performance Obligation (Details)          HTML     38K 
40: R29         Revenue - Narrative (Details)                       HTML     31K 
41: R30         Investments and Fair Value Measurements -           HTML    109K 
                Narrative (Details)                                              
42: R31         Investments and Fair Value Measurements - Schedule  HTML     29K 
                of Marketable Equity Securities (Details)                        
43: R32         Investments and Fair Value Measurements - Fair      HTML     57K 
                Value Hierarchy of Assets and Liabilities                        
                (Details)                                                        
44: R33         Investments and Fair Value Measurements - Changes   HTML     28K 
                in Estimated Fair Value of Acquisition Related                   
                Contingent Consideration Liabilities (Details)                   
45: R34         Debt - Summary of Term Debt Obligations (Details)   HTML     55K 
46: R35         Debt - Narrative (Details)                          HTML    118K 
47: R36         Debt - Summary of Convertible Debt Obligations      HTML     44K 
                (Details)                                                        
48: R37         Stockholders? Equity - Narrative (Details)          HTML     48K 
49: R38         Stockholders? Equity - Summary of Restricted Stock  HTML     52K 
                Activity and Related Information (Details)                       
50: R39         Stockholders? Equity - Summary of Stock Option      HTML     51K 
                Activity Under all Stock Option Plans (Details)                  
51: R40         Stockholders? Equity - Narrative - Other Liability  HTML     45K 
                - Classified Awards (Details)                                    
52: R41         Stockholders? Equity - Other Liability -            HTML     36K 
                Classified Awards (Details)                                      
53: R42         Stockholders? Equity - Narrative - Employee Stock   HTML     38K 
                Purchase Plan (Details)                                          
54: R43         Stockholders? Equity- Summary of Assumptions Used   HTML     50K 
                to Estimate the Weighted Average Fair Value Per                  
                Share (Details)                                                  
55: R44         Stockholders? Equity - Narrative - Share            HTML     34K 
                Repurchases (Details)                                            
56: R45         Stockholders? Equity - Summary of Share-based       HTML     46K 
                Compensation Expense for all Stock Awards                        
                (Details)                                                        
57: R46         Supplemental Balance Sheet Details - Schedule of    HTML     29K 
                Accounts Receivable (Details)                                    
58: R47         Supplemental Balance Sheet Details - Summary of     HTML     34K 
                Inventory (Details)                                              
59: R48         Supplemental Balance Sheet Details - Summary of     HTML     39K 
                Accrued Liabilities (Details)                                    
60: R49         Supplemental Balance Sheet Details - Summary of     HTML     29K 
                Changes in Reserve for Product Warranties                        
                (Details)                                                        
61: R50         Supplemental Balance Sheet Details - Pre-Tax        HTML     36K 
                Restructuring Charge (Details)                                   
62: R51         Supplemental Balance Sheet Details - Pre-Tax        HTML     45K 
                Charges and Total Costs (Details)                                
63: R52         Supplemental Balance Sheet Details - Narrative -    HTML     29K 
                Warranties (Details)                                             
64: R53         Supplemental Balance Sheet Details - Narrative -    HTML     44K 
                Goodwill (Details)                                               
65: R54         Supplemental Balance Sheet Details - Narrative -    HTML     51K 
                Derivatives (Details)                                            
66: R55         Legal Proceedings (Details)                         HTML     33K 
67: R56         Income Taxes (Details)                              HTML     33K 
68: R57         Segment Information - Summary of Operating          HTML     43K 
                Performance and Assets by Segment (Details)                      
71: XML         IDEA XML File -- Filing Summary                      XML    130K 
69: XML         XBRL Instance -- ilmn-20230702_htm                   XML   1.74M 
70: EXCEL       IDEA Workbook of Financial Report Info              XLSX    129K 
 8: EX-101.CAL  XBRL Calculations -- ilmn-20230702_cal               XML    167K 
 9: EX-101.DEF  XBRL Definitions -- ilmn-20230702_def                XML    662K 
10: EX-101.LAB  XBRL Labels -- ilmn-20230702_lab                     XML   1.73M 
11: EX-101.PRE  XBRL Presentations -- ilmn-20230702_pre              XML   1.02M 
 7: EX-101.SCH  XBRL Schema -- ilmn-20230702                         XSD    148K 
72: JSON        XBRL Instance as JSON Data -- MetaLinks              518±   764K 
73: ZIP         XBRL Zipped Folder -- 0001110803-23-000064-xbrl      Zip    370K 


‘EX-101.CAL’   —   XBRL Calculations — ilmn-20230702_cal


This Exhibit is an XBRL File.


                                                                                                                                                                                
<?xml version="1.0" encoding="windows-1252"?>
<!-- XBRL Document Created with the Workiva Platform -->
<!-- Copyright 2023 Workiva -->
<!-- r:11d9117d-3d80-45c8-b030-6bb5747865b3,g:b2b0e67b-de9a-4173-a190-403e6751e35c -->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
<link:roleRef roleURI="http://www.illumina.com/role/CondensedConsolidatedBalanceSheets" xlink:type="simple" xlink:href="ilmn-20230702.xsd#CondensedConsolidatedBalanceSheets"/>
<link:calculationLink xlink:role="http://www.illumina.com/role/CondensedConsolidatedBalanceSheets" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_d5cfe3cb-fc22-4aeb-95ea-64134c19577d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Assets"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_f982c50d-26e7-4c0f-8a9f-0efa5435b760" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsCurrent"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d5cfe3cb-fc22-4aeb-95ea-64134c19577d" xlink:to="loc_us-gaap_AssetsCurrent_f982c50d-26e7-4c0f-8a9f-0efa5435b760" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_e9ac4069-b357-4588-80d5-3563b28ff4f7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d5cfe3cb-fc22-4aeb-95ea-64134c19577d" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_e9ac4069-b357-4588-80d5-3563b28ff4f7" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_a1d02077-6936-4dc6-b96c-23ee7f6b2325" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d5cfe3cb-fc22-4aeb-95ea-64134c19577d" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_a1d02077-6936-4dc6-b96c-23ee7f6b2325" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_9cff718c-b9c0-46e3-b35d-669f6b397214" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Goodwill"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d5cfe3cb-fc22-4aeb-95ea-64134c19577d" xlink:to="loc_us-gaap_Goodwill_9cff718c-b9c0-46e3-b35d-669f6b397214" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_32c7ef00-e220-4c49-afdc-5f8ecbb2b036" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
<link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d5cfe3cb-fc22-4aeb-95ea-64134c19577d" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_32c7ef00-e220-4c49-afdc-5f8ecbb2b036" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_217bd75a-7fd7-41f3-8421-06831829f562" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherAssetsNoncurrent"/>
<link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d5cfe3cb-fc22-4aeb-95ea-64134c19577d" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_217bd75a-7fd7-41f3-8421-06831829f562" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_275ebc30-b5bc-4513-b06a-15d6244cad0f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesCurrent"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_a846b2be-ac68-4856-ba7c-2c378578edc9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsPayableCurrent"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_275ebc30-b5bc-4513-b06a-15d6244cad0f" xlink:to="loc_us-gaap_AccountsPayableCurrent_a846b2be-ac68-4856-ba7c-2c378578edc9" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_56376391-de2f-435a-a8b3-d4eb105e2e4c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_275ebc30-b5bc-4513-b06a-15d6244cad0f" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_56376391-de2f-435a-a8b3-d4eb105e2e4c" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesPayableCurrent_9b043903-0363-4bc5-b5ec-92e1d4817a9e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NotesPayableCurrent"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_275ebc30-b5bc-4513-b06a-15d6244cad0f" xlink:to="loc_us-gaap_NotesPayableCurrent_9b043903-0363-4bc5-b5ec-92e1d4817a9e" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtCurrent_157d83be-75be-4172-ab6f-4dfe94c01c45" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConvertibleDebtCurrent"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_275ebc30-b5bc-4513-b06a-15d6244cad0f" xlink:to="loc_us-gaap_ConvertibleDebtCurrent_157d83be-75be-4172-ab6f-4dfe94c01c45" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_b350b0c0-5865-45f3-a6cd-a60d7b357c45" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsCurrent"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_a8b5446d-4486-4a60-a4f6-60f4c5647423" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_b350b0c0-5865-45f3-a6cd-a60d7b357c45" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_a8b5446d-4486-4a60-a4f6-60f4c5647423" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_d938118e-bd6f-464d-9acf-69cc806286f2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShortTermInvestments"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_b350b0c0-5865-45f3-a6cd-a60d7b357c45" xlink:to="loc_us-gaap_ShortTermInvestments_d938118e-bd6f-464d-9acf-69cc806286f2" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_146bd408-5929-4369-aca3-b65f84c6a146" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsReceivableNetCurrent"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_b350b0c0-5865-45f3-a6cd-a60d7b357c45" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_146bd408-5929-4369-aca3-b65f84c6a146" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_724d85ab-a915-4d83-bc77-4b78c79ef716" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryNet"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_b350b0c0-5865-45f3-a6cd-a60d7b357c45" xlink:to="loc_us-gaap_InventoryNet_724d85ab-a915-4d83-bc77-4b78c79ef716" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_709c0d47-3042-4547-a396-f4f0427d7917" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
<link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_b350b0c0-5865-45f3-a6cd-a60d7b357c45" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_709c0d47-3042-4547-a396-f4f0427d7917" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_0a578f65-c7d0-46de-9cf6-db994dd23c85" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_369a0b34-93d6-4155-b9df-878a9864a680" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockValue"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_0a578f65-c7d0-46de-9cf6-db994dd23c85" xlink:to="loc_us-gaap_CommonStockValue_369a0b34-93d6-4155-b9df-878a9864a680" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_504f0de8-f0bc-4323-abbd-9eae3752dd72" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdditionalPaidInCapital"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_0a578f65-c7d0-46de-9cf6-db994dd23c85" xlink:to="loc_us-gaap_AdditionalPaidInCapital_504f0de8-f0bc-4323-abbd-9eae3752dd72" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_464addcf-e693-48e3-8fb5-5ad5d6e45073" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_0a578f65-c7d0-46de-9cf6-db994dd23c85" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_464addcf-e693-48e3-8fb5-5ad5d6e45073" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_3e8117d0-60f1-44aa-817e-642e13374ec7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_0a578f65-c7d0-46de-9cf6-db994dd23c85" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_3e8117d0-60f1-44aa-817e-642e13374ec7" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValue_b43ba29d-385c-4878-a574-1a3a4f81f298" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TreasuryStockValue"/>
<link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_0a578f65-c7d0-46de-9cf6-db994dd23c85" xlink:to="loc_us-gaap_TreasuryStockValue_b43ba29d-385c-4878-a574-1a3a4f81f298" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_c0edc1f0-cb9b-4376-8667-945e26446e17" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_0cdc2c9b-c53e-4367-9517-7a729a06a0aa" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesCurrent"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_c0edc1f0-cb9b-4376-8667-945e26446e17" xlink:to="loc_us-gaap_LiabilitiesCurrent_0cdc2c9b-c53e-4367-9517-7a729a06a0aa" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_684f8ec3-2b7a-4553-aad3-9a1bf637b657" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_c0edc1f0-cb9b-4376-8667-945e26446e17" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_684f8ec3-2b7a-4553-aad3-9a1bf637b657" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermNotesPayable_fba0754c-1242-4aeb-b8b9-7cd56ce6df68" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermNotesPayable"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_c0edc1f0-cb9b-4376-8667-945e26446e17" xlink:to="loc_us-gaap_LongTermNotesPayable_fba0754c-1242-4aeb-b8b9-7cd56ce6df68" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_4fa710f6-2be1-43e4-9408-393a2104c4cc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_c0edc1f0-cb9b-4376-8667-945e26446e17" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_4fa710f6-2be1-43e4-9408-393a2104c4cc" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_4f049152-b55e-467e-a7b3-1911300305a9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
<link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_c0edc1f0-cb9b-4376-8667-945e26446e17" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_4f049152-b55e-467e-a7b3-1911300305a9" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.illumina.com/role/CondensedConsolidatedStatementsofOperations" xlink:type="simple" xlink:href="ilmn-20230702.xsd#CondensedConsolidatedStatementsofOperations"/>
<link:calculationLink xlink:role="http://www.illumina.com/role/CondensedConsolidatedStatementsofOperations" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_279ab92e-f89d-4692-938c-b64bad09df95" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostOfRevenue"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_c14b80f0-5b82-4db8-b923-42125f7fa63c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostOfRevenue_279ab92e-f89d-4692-938c-b64bad09df95" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_c14b80f0-5b82-4db8-b923-42125f7fa63c" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSoldAmortization_2a2b45ef-4d5d-4f79-be7b-75ae693ff9ba" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostOfGoodsAndServicesSoldAmortization"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostOfRevenue_279ab92e-f89d-4692-938c-b64bad09df95" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSoldAmortization_2a2b45ef-4d5d-4f79-be7b-75ae693ff9ba" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_a231a6d0-7234-4fd1-b94f-4be80b81e088" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingIncomeLoss"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_78715c50-597e-468a-ad7b-65121ee9e730" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GrossProfit"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_a231a6d0-7234-4fd1-b94f-4be80b81e088" xlink:to="loc_us-gaap_GrossProfit_78715c50-597e-468a-ad7b-65121ee9e730" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_ea4d227a-30d9-4231-8f58-a42f5bce088c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingExpenses"/>
<link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_a231a6d0-7234-4fd1-b94f-4be80b81e088" xlink:to="loc_us-gaap_OperatingExpenses_ea4d227a-30d9-4231-8f58-a42f5bce088c" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_39404a69-84b3-4e00-8af0-4f93c77372e0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingExpenses"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_ad407d72-b9c1-4ca2-b9f6-58c34b80aea0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_39404a69-84b3-4e00-8af0-4f93c77372e0" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_ad407d72-b9c1-4ca2-b9f6-58c34b80aea0" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_cd92a190-ada0-48ec-9c98-6c2d9c87feb6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_39404a69-84b3-4e00-8af0-4f93c77372e0" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_cd92a190-ada0-48ec-9c98-6c2d9c87feb6" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossRelatedToLitigationSettlement_848540f1-8bbd-484d-8886-ea0220d5ea5d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GainLossRelatedToLitigationSettlement"/>
<link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_39404a69-84b3-4e00-8af0-4f93c77372e0" xlink:to="loc_us-gaap_GainLossRelatedToLitigationSettlement_848540f1-8bbd-484d-8886-ea0220d5ea5d" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_a93a4096-dbb2-4a6c-8651-8ba123aa2a8d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GrossProfit"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_aa6a5234-b6f4-451c-8304-c41969a3bf84" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_a93a4096-dbb2-4a6c-8651-8ba123aa2a8d" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_aa6a5234-b6f4-451c-8304-c41969a3bf84" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_cda8bfd4-3981-4579-a027-10ee62625c6f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostOfRevenue"/>
<link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_a93a4096-dbb2-4a6c-8651-8ba123aa2a8d" xlink:to="loc_us-gaap_CostOfRevenue_cda8bfd4-3981-4579-a027-10ee62625c6f" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_f1d39814-0025-4b29-b931-d3a8388090c1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_736ebf91-0d36-494b-b116-fc4a562c02ba" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingIncomeLoss"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_f1d39814-0025-4b29-b931-d3a8388090c1" xlink:to="loc_us-gaap_OperatingIncomeLoss_736ebf91-0d36-494b-b116-fc4a562c02ba" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_b6746b71-e4fe-4f04-8a90-6132dd896eb0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NonoperatingIncomeExpense"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_f1d39814-0025-4b29-b931-d3a8388090c1" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_b6746b71-e4fe-4f04-8a90-6132dd896eb0" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_d400c949-8fad-48a4-89e9-88681eab7898" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NonoperatingIncomeExpense"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_e7fdf048-11d0-4341-98dd-d2990fe28135" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InvestmentIncomeInterest"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_d400c949-8fad-48a4-89e9-88681eab7898" xlink:to="loc_us-gaap_InvestmentIncomeInterest_e7fdf048-11d0-4341-98dd-d2990fe28135" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_05c0ae6b-cc9e-4d56-abb0-6f88e8a5f814" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestExpense"/>
<link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_d400c949-8fad-48a4-89e9-88681eab7898" xlink:to="loc_us-gaap_InterestExpense_05c0ae6b-cc9e-4d56-abb0-6f88e8a5f814" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_e362d5a9-78fc-4ead-9416-67fc829d69b3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_d400c949-8fad-48a4-89e9-88681eab7898" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_e362d5a9-78fc-4ead-9416-67fc829d69b3" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_e229a85c-ef12-437b-b04f-b4aba1ba44d8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_418c0cdc-dc69-49ba-8963-dcb6bfde6e58" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_e229a85c-ef12-437b-b04f-b4aba1ba44d8" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_418c0cdc-dc69-49ba-8963-dcb6bfde6e58" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_d9885288-5ba2-4d6f-9e3f-63a26cb6dcd7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
<link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_e229a85c-ef12-437b-b04f-b4aba1ba44d8" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_d9885288-5ba2-4d6f-9e3f-63a26cb6dcd7" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.illumina.com/role/CondensedConsolidatedStatementsofComprehensiveIncomeLoss" xlink:type="simple" xlink:href="ilmn-20230702.xsd#CondensedConsolidatedStatementsofComprehensiveIncomeLoss"/>
<link:calculationLink xlink:role="http://www.illumina.com/role/CondensedConsolidatedStatementsofComprehensiveIncomeLoss" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_265293d4-c834-4f7c-b7ac-8988b32a66f8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_5e94e604-370f-4de9-86a7-4c5f08f9769d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_265293d4-c834-4f7c-b7ac-8988b32a66f8" xlink:to="loc_us-gaap_NetIncomeLoss_5e94e604-370f-4de9-86a7-4c5f08f9769d" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTaxParent_91405a47-3822-4137-8624-7281ad4ee92b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTaxParent"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_265293d4-c834-4f7c-b7ac-8988b32a66f8" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTaxParent_91405a47-3822-4137-8624-7281ad4ee92b" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.illumina.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="ilmn-20230702.xsd#CondensedConsolidatedStatementsofCashFlows"/>
<link:calculationLink xlink:role="http://www.illumina.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_ccaaf948-8549-4298-aaef-bc1a0439c814" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
<link:loc xlink:type="locator" xlink:label="loc_ilmn_ProceedsFromStrategicInvestments_04c85afc-bbd0-428c-9444-99e6754b1db9" xlink:href="ilmn-20230702.xsd#ilmn_ProceedsFromStrategicInvestments"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_ccaaf948-8549-4298-aaef-bc1a0439c814" xlink:to="loc_ilmn_ProceedsFromStrategicInvestments_04c85afc-bbd0-428c-9444-99e6754b1db9" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_ilmn_PaymentsForStrategicInvestments_fd1b9619-4e45-42a1-9153-e8cdab157b9e" xlink:href="ilmn-20230702.xsd#ilmn_PaymentsForStrategicInvestments"/>
<link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_ccaaf948-8549-4298-aaef-bc1a0439c814" xlink:to="loc_ilmn_PaymentsForStrategicInvestments_fd1b9619-4e45-42a1-9153-e8cdab157b9e" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_1247a643-bdce-484e-b061-92bbaf6c7cba" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
<link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_ccaaf948-8549-4298-aaef-bc1a0439c814" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_1247a643-bdce-484e-b061-92bbaf6c7cba" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireIntangibleAssets_978794ea-029c-4505-949b-b97c07b7af54" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquireIntangibleAssets"/>
<link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_ccaaf948-8549-4298-aaef-bc1a0439c814" xlink:to="loc_us-gaap_PaymentsToAcquireIntangibleAssets_978794ea-029c-4505-949b-b97c07b7af54" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_436a16fe-c6b9-4e6e-891f-29c919bfcf0f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
<link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_ccaaf948-8549-4298-aaef-bc1a0439c814" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_436a16fe-c6b9-4e6e-891f-29c919bfcf0f" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_525258cc-829b-4cef-97fd-12f41a7eff57" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1e0ba18c-765f-4b52-8bbf-be24fec2e78e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_525258cc-829b-4cef-97fd-12f41a7eff57" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1e0ba18c-765f-4b52-8bbf-be24fec2e78e" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_1fd87d29-411b-4902-8e77-9d14e2a08465" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_525258cc-829b-4cef-97fd-12f41a7eff57" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_1fd87d29-411b-4902-8e77-9d14e2a08465" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_14393015-43e7-48b1-9103-0bb1d07cd247" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_525258cc-829b-4cef-97fd-12f41a7eff57" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_14393015-43e7-48b1-9103-0bb1d07cd247" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_29cf9b4b-5e5d-463b-8a75-e1b0e73a731d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_525258cc-829b-4cef-97fd-12f41a7eff57" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_29cf9b4b-5e5d-463b-8a75-e1b0e73a731d" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb4148cd-16ca-47ab-b182-47d398f9c37e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_501f59e6-e1a8-44f6-8431-1aabaccc04e8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb4148cd-16ca-47ab-b182-47d398f9c37e" xlink:to="loc_us-gaap_NetIncomeLoss_501f59e6-e1a8-44f6-8431-1aabaccc04e8" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_18a9092c-5c04-4811-951c-5270b76e6364" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Depreciation"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb4148cd-16ca-47ab-b182-47d398f9c37e" xlink:to="loc_us-gaap_Depreciation_18a9092c-5c04-4811-951c-5270b76e6364" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_dfb9dbf5-ab84-4b57-922e-67692fe63518" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb4148cd-16ca-47ab-b182-47d398f9c37e" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_dfb9dbf5-ab84-4b57-922e-67692fe63518" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_324ad729-5568-4720-8882-1ff989bdd898" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensation"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb4148cd-16ca-47ab-b182-47d398f9c37e" xlink:to="loc_us-gaap_ShareBasedCompensation_324ad729-5568-4720-8882-1ff989bdd898" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_79c5d572-fa99-46f1-91ec-40b012686106" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInDeferredIncomeTaxes"/>
<link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb4148cd-16ca-47ab-b182-47d398f9c37e" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_79c5d572-fa99-46f1-91ec-40b012686106" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnInvestments_b7e1c1b3-7e22-4f2f-99b1-5336c91abdf7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GainLossOnInvestments"/>
<link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb4148cd-16ca-47ab-b182-47d398f9c37e" xlink:to="loc_us-gaap_GainLossOnInvestments_b7e1c1b3-7e22-4f2f-99b1-5336c91abdf7" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_ilmn_ContingentValueRightUnrealizedGainLoss_cac65e3f-c9d0-41f0-8179-41fc1cb045c5" xlink:href="ilmn-20230702.xsd#ilmn_ContingentValueRightUnrealizedGainLoss"/>
<link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb4148cd-16ca-47ab-b182-47d398f9c37e" xlink:to="loc_ilmn_ContingentValueRightUnrealizedGainLoss_cac65e3f-c9d0-41f0-8179-41fc1cb045c5" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_fe06df26-520f-41a3-ba21-a0f6844b9796" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1"/>
<link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb4148cd-16ca-47ab-b182-47d398f9c37e" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_fe06df26-520f-41a3-ba21-a0f6844b9796" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_73d05c23-bc39-416a-a546-c260a91e60ec" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherNoncashIncomeExpense"/>
<link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb4148cd-16ca-47ab-b182-47d398f9c37e" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_73d05c23-bc39-416a-a546-c260a91e60ec" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_b7ed9bdf-468d-40ba-98f5-250d9806e698" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
<link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb4148cd-16ca-47ab-b182-47d398f9c37e" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_b7ed9bdf-468d-40ba-98f5-250d9806e698" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_41cd0182-9cf5-4de0-b153-52f19f284ea3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInInventories"/>
<link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb4148cd-16ca-47ab-b182-47d398f9c37e" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_41cd0182-9cf5-4de0-b153-52f19f284ea3" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_060a7bf2-1a32-4d6c-8928-1aff1425e71e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
<link:calculationArc order="12" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb4148cd-16ca-47ab-b182-47d398f9c37e" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_060a7bf2-1a32-4d6c-8928-1aff1425e71e" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_ilmn_IncreaseDecreaseOfOperatingLeasesNet_39ff4bf9-db28-46de-95ac-ece949398c1b" xlink:href="ilmn-20230702.xsd#ilmn_IncreaseDecreaseOfOperatingLeasesNet"/>
<link:calculationArc order="13" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb4148cd-16ca-47ab-b182-47d398f9c37e" xlink:to="loc_ilmn_IncreaseDecreaseOfOperatingLeasesNet_39ff4bf9-db28-46de-95ac-ece949398c1b" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_f2b2e8d2-d620-4a55-bb03-a72e06fd3233" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentAssets"/>
<link:calculationArc order="14" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb4148cd-16ca-47ab-b182-47d398f9c37e" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_f2b2e8d2-d620-4a55-bb03-a72e06fd3233" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_1bc56825-fa84-42d5-b3a9-df871cb205b2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
<link:calculationArc order="15" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb4148cd-16ca-47ab-b182-47d398f9c37e" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_1bc56825-fa84-42d5-b3a9-df871cb205b2" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_edd4f719-077a-4338-8a90-6bab254ecd57" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
<link:calculationArc order="16" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb4148cd-16ca-47ab-b182-47d398f9c37e" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_edd4f719-077a-4338-8a90-6bab254ecd57" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_69fe8695-0fb2-4c94-812d-ce9b6b237bec" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities"/>
<link:calculationArc order="17" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb4148cd-16ca-47ab-b182-47d398f9c37e" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_69fe8695-0fb2-4c94-812d-ce9b6b237bec" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_e428842b-49d7-456f-a020-b8fe30e53b51" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf"/>
<link:calculationArc order="18" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fb4148cd-16ca-47ab-b182-47d398f9c37e" xlink:to="loc_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_e428842b-49d7-456f-a020-b8fe30e53b51" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_555db607-e4ba-4e16-b41a-cc7c45b50c7b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_7e717ff4-7946-4d12-866c-ccc405e2e1df" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
<link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_555db607-e4ba-4e16-b41a-cc7c45b50c7b" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_7e717ff4-7946-4d12-866c-ccc405e2e1df" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_51c30103-ace0-4893-88a3-7c809f16122d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsOfDebtIssuanceCosts"/>
<link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_555db607-e4ba-4e16-b41a-cc7c45b50c7b" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_51c30103-ace0-4893-88a3-7c809f16122d" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_a41353a8-d9f6-4805-99ce-41c50799b61f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_555db607-e4ba-4e16-b41a-cc7c45b50c7b" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_a41353a8-d9f6-4805-99ce-41c50799b61f" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_4c7eaa50-e7ee-48c2-9be8-5313fff233d9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
<link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_555db607-e4ba-4e16-b41a-cc7c45b50c7b" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_4c7eaa50-e7ee-48c2-9be8-5313fff233d9" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.illumina.com/role/OrganizationandSignificantAccountingPoliciesSummaryofCalculationofWeightedAverageSharesusedtoCalculateBasicandDilutedEarningsPerShareDetails" xlink:type="simple" xlink:href="ilmn-20230702.xsd#OrganizationandSignificantAccountingPoliciesSummaryofCalculationofWeightedAverageSharesusedtoCalculateBasicandDilutedEarningsPerShareDetails"/>
<link:calculationLink xlink:role="http://www.illumina.com/role/OrganizationandSignificantAccountingPoliciesSummaryofCalculationofWeightedAverageSharesusedtoCalculateBasicandDilutedEarningsPerShareDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_9cb0f32c-9a02-4e69-ada4-41ba9e6e5c43" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_c6388314-085f-4c62-bbb5-a3ff7217e345" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_9cb0f32c-9a02-4e69-ada4-41ba9e6e5c43" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_c6388314-085f-4c62-bbb5-a3ff7217e345" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.illumina.com/role/InvestmentsandFairValueMeasurementsScheduleofMarketableEquitySecuritiesDetails" xlink:type="simple" xlink:href="ilmn-20230702.xsd#InvestmentsandFairValueMeasurementsScheduleofMarketableEquitySecuritiesDetails"/>
<link:calculationLink xlink:role="http://www.illumina.com/role/InvestmentsandFairValueMeasurementsScheduleofMarketableEquitySecuritiesDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiGainLoss_760dc8c5-18f5-45b5-a2e6-17c1ef3c00f4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquitySecuritiesFvNiGainLoss"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss_202b7dbe-f494-4aba-aa99-f8709cd994a1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EquitySecuritiesFvNiGainLoss_760dc8c5-18f5-45b5-a2e6-17c1ef3c00f4" xlink:to="loc_us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss_202b7dbe-f494-4aba-aa99-f8709cd994a1" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiRealizedGainLoss_1cd96726-177b-4048-be0e-0090bada750c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquitySecuritiesFvNiRealizedGainLoss"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EquitySecuritiesFvNiGainLoss_760dc8c5-18f5-45b5-a2e6-17c1ef3c00f4" xlink:to="loc_us-gaap_EquitySecuritiesFvNiRealizedGainLoss_1cd96726-177b-4048-be0e-0090bada750c" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.illumina.com/role/InvestmentsandFairValueMeasurementsFairValueHierarchyofAssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="ilmn-20230702.xsd#InvestmentsandFairValueMeasurementsFairValueHierarchyofAssetsandLiabilitiesDetails"/>
<link:calculationLink xlink:role="http://www.illumina.com/role/InvestmentsandFairValueMeasurementsFairValueHierarchyofAssetsandLiabilitiesDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_eb48658f-76e0-4c7e-baf7-7d93e3bdeac9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_d8045562-4690-4d07-a1b3-2f6c9a34b3ed" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_eb48658f-76e0-4c7e-baf7-7d93e3bdeac9" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_d8045562-4690-4d07-a1b3-2f6c9a34b3ed" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredCompensationLiabilityCurrentAndNoncurrent_bba88d22-190c-491f-bcd4-6e80c462ea4e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredCompensationLiabilityCurrentAndNoncurrent"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_eb48658f-76e0-4c7e-baf7-7d93e3bdeac9" xlink:to="loc_us-gaap_DeferredCompensationLiabilityCurrentAndNoncurrent_bba88d22-190c-491f-bcd4-6e80c462ea4e" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_859cf109-4556-4fff-9774-4e9ec4614b78" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsFairValueDisclosure"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_b1b545b5-d06e-4b37-bceb-70cce17a1e5d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_859cf109-4556-4fff-9774-4e9ec4614b78" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_b1b545b5-d06e-4b37-bceb-70cce17a1e5d" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_f699407f-fcb1-43f9-af25-4faa1a6d16c0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquitySecuritiesFvNi"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_859cf109-4556-4fff-9774-4e9ec4614b78" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_f699407f-fcb1-43f9-af25-4faa1a6d16c0" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_ilmn_ContingentValueRightFairValueDisclosure_bdbf4323-7db7-4704-b4b8-602cd2677103" xlink:href="ilmn-20230702.xsd#ilmn_ContingentValueRightFairValueDisclosure"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_859cf109-4556-4fff-9774-4e9ec4614b78" xlink:to="loc_ilmn_ContingentValueRightFairValueDisclosure_bdbf4323-7db7-4704-b4b8-602cd2677103" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredCompensationPlanAssets_4e400e3a-0b3b-4934-bf4b-eac45ef0de93" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredCompensationPlanAssets"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_859cf109-4556-4fff-9774-4e9ec4614b78" xlink:to="loc_us-gaap_DeferredCompensationPlanAssets_4e400e3a-0b3b-4934-bf4b-eac45ef0de93" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.illumina.com/role/DebtSummaryofConvertibleDebtObligationsDetails" xlink:type="simple" xlink:href="ilmn-20230702.xsd#DebtSummaryofConvertibleDebtObligationsDetails"/>
<link:calculationLink xlink:role="http://www.illumina.com/role/DebtSummaryofConvertibleDebtObligationsDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_edac9b0b-2d8e-4729-a015-b4f7e60991a1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtLongtermAndShorttermCombinedAmount"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_2df5a01f-bdfa-4930-ac41-ce808171f486" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentFaceAmount"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_edac9b0b-2d8e-4729-a015-b4f7e60991a1" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_2df5a01f-bdfa-4930-ac41-ce808171f486" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_48069663-f829-40ab-8d9d-77bb2c854f60" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentUnamortizedDiscount"/>
<link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_edac9b0b-2d8e-4729-a015-b4f7e60991a1" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_48069663-f829-40ab-8d9d-77bb2c854f60" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.illumina.com/role/StockholdersEquitySummaryofSharebasedCompensationExpenseforallStockAwardsDetails" xlink:type="simple" xlink:href="ilmn-20230702.xsd#StockholdersEquitySummaryofSharebasedCompensationExpenseforallStockAwardsDetails"/>
<link:calculationLink xlink:role="http://www.illumina.com/role/StockholdersEquitySummaryofSharebasedCompensationExpenseforallStockAwardsDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_f644b508-a2a8-4b71-8099-4bd26926be63" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_b16dfbca-5f5a-4b99-b3f4-73dc48bea032" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_f644b508-a2a8-4b71-8099-4bd26926be63" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_b16dfbca-5f5a-4b99-b3f4-73dc48bea032" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_5de0a7b5-e8ea-4e1d-9464-247cd4ccde12" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense"/>
<link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_f644b508-a2a8-4b71-8099-4bd26926be63" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_5de0a7b5-e8ea-4e1d-9464-247cd4ccde12" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.illumina.com/role/SupplementalBalanceSheetDetailsScheduleofAccountsReceivableDetails" xlink:type="simple" xlink:href="ilmn-20230702.xsd#SupplementalBalanceSheetDetailsScheduleofAccountsReceivableDetails"/>
<link:calculationLink xlink:role="http://www.illumina.com/role/SupplementalBalanceSheetDetailsScheduleofAccountsReceivableDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_8059a759-4a5d-4600-8ad0-2b85dfa81d79" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsReceivableNetCurrent"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableGrossCurrent_301235d5-6ff1-485b-8654-6a4a75dd6f66" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsReceivableGrossCurrent"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsReceivableNetCurrent_8059a759-4a5d-4600-8ad0-2b85dfa81d79" xlink:to="loc_us-gaap_AccountsReceivableGrossCurrent_301235d5-6ff1-485b-8654-6a4a75dd6f66" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_7ba93cab-56c8-43da-ab42-e3ab462e0604" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent"/>
<link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsReceivableNetCurrent_8059a759-4a5d-4600-8ad0-2b85dfa81d79" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_7ba93cab-56c8-43da-ab42-e3ab462e0604" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.illumina.com/role/SupplementalBalanceSheetDetailsSummaryofInventoryDetails" xlink:type="simple" xlink:href="ilmn-20230702.xsd#SupplementalBalanceSheetDetailsSummaryofInventoryDetails"/>
<link:calculationLink xlink:role="http://www.illumina.com/role/SupplementalBalanceSheetDetailsSummaryofInventoryDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_e0c6b687-4b49-4338-bf75-4f0c3f7bd648" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryNet"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryGross_7d3dd3ca-c79b-49e6-8e42-608a4bfe339a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryGross"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_e0c6b687-4b49-4338-bf75-4f0c3f7bd648" xlink:to="loc_us-gaap_InventoryGross_7d3dd3ca-c79b-49e6-8e42-608a4bfe339a" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryValuationReserves_2b9b500e-5f42-444d-9d9f-5807f0df4d52" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryValuationReserves"/>
<link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_e0c6b687-4b49-4338-bf75-4f0c3f7bd648" xlink:to="loc_us-gaap_InventoryValuationReserves_2b9b500e-5f42-444d-9d9f-5807f0df4d52" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryGross_bc542f3d-19f0-4b31-b00e-7e96361a331b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryGross"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterials_374dc08b-6414-47d9-b94b-2254a838a1d7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryRawMaterials"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryGross_bc542f3d-19f0-4b31-b00e-7e96361a331b" xlink:to="loc_us-gaap_InventoryRawMaterials_374dc08b-6414-47d9-b94b-2254a838a1d7" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcess_8e6884cb-0f9a-4ea9-b4f4-5686b3979a25" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryWorkInProcess"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryGross_bc542f3d-19f0-4b31-b00e-7e96361a331b" xlink:to="loc_us-gaap_InventoryWorkInProcess_8e6884cb-0f9a-4ea9-b4f4-5686b3979a25" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoods_ba9f2139-58eb-443b-9376-233cd42d217c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryFinishedGoods"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryGross_bc542f3d-19f0-4b31-b00e-7e96361a331b" xlink:to="loc_us-gaap_InventoryFinishedGoods_ba9f2139-58eb-443b-9376-233cd42d217c" xlink:type="arc"/>
</link:calculationLink>
<link:roleRef roleURI="http://www.illumina.com/role/SupplementalBalanceSheetDetailsSummaryofAccruedLiabilitiesDetails" xlink:type="simple" xlink:href="ilmn-20230702.xsd#SupplementalBalanceSheetDetailsSummaryofAccruedLiabilitiesDetails"/>
<link:calculationLink xlink:role="http://www.illumina.com/role/SupplementalBalanceSheetDetailsSummaryofAccruedLiabilitiesDetails" xlink:type="extended">
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_a900bd11-a822-4421-a7cd-e6dee353e3e0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationReserveCurrent_0c420c58-130f-4005-8fce-c65e700c8151" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LitigationReserveCurrent"/>
<link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_a900bd11-a822-4421-a7cd-e6dee353e3e0" xlink:to="loc_us-gaap_LitigationReserveCurrent_0c420c58-130f-4005-8fce-c65e700c8151" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_115e0043-4a49-46da-8d18-3f9463c614d9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
<link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_a900bd11-a822-4421-a7cd-e6dee353e3e0" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_115e0043-4a49-46da-8d18-3f9463c614d9" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_929f554f-b0e6-4d52-a033-e13e4b56451a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
<link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_a900bd11-a822-4421-a7cd-e6dee353e3e0" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_929f554f-b0e6-4d52-a033-e13e4b56451a" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxesPayableCurrent_cc0491bd-2212-4f00-88c4-d288979a08fc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TaxesPayableCurrent"/>
<link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_a900bd11-a822-4421-a7cd-e6dee353e3e0" xlink:to="loc_us-gaap_TaxesPayableCurrent_cc0491bd-2212-4f00-88c4-d288979a08fc" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_e940ee9a-3b8b-45c4-b7b7-b8021c86478d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
<link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_a900bd11-a822-4421-a7cd-e6dee353e3e0" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_e940ee9a-3b8b-45c4-b7b7-b8021c86478d" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_ilmn_AccruedLiabilityClassifiedAwardsCurrent_48e0cf51-7b54-4724-8fd4-44db6b30e6c7" xlink:href="ilmn-20230702.xsd#ilmn_AccruedLiabilityClassifiedAwardsCurrent"/>
<link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_a900bd11-a822-4421-a7cd-e6dee353e3e0" xlink:to="loc_ilmn_AccruedLiabilityClassifiedAwardsCurrent_48e0cf51-7b54-4724-8fd4-44db6b30e6c7" xlink:type="arc"/>
<link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_82a713ef-7494-4a48-bef8-3d93253e670e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
<link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_a900bd11-a822-4421-a7cd-e6dee353e3e0" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_82a713ef-7494-4a48-bef8-3d93253e670e" xlink:type="arc"/>
</link:calculationLink>
</link:linkbase>


4 Subsequent Filings that Reference this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 2/16/24  Illumina, Inc.                    10-K       12/31/23  111:18M
 1/09/24  Illumina, Inc.                    8-K:2,9     1/09/24   11:227K
11/13/23  Illumina, Inc.                    10-Q       10/01/23   75:8.2M
11/09/23  Illumina, Inc.                    8-K:2,9    11/09/23   11:1.2M


5 Previous Filings that this Filing References

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 5/05/23  Illumina, Inc.                    10-Q        4/02/23   67:7.1M
 2/17/23  Illumina, Inc.                    10-K        1/01/23  108:17M
 8/11/22  Illumina, Inc.                    10-Q        7/03/22   72:9M
 2/18/22  Illumina, Inc.                    10-K        1/02/22  108:15M
 8/18/21  Illumina, Inc.                    8-K:1,2,8,9 8/18/21   12:686K                                   Cravath Swaine & … 01/FA
Top
Filing Submission 0001110803-23-000064   –   Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)

Copyright © 2024 Fran Finnegan & Company LLC – All Rights Reserved.
AboutPrivacyRedactionsHelp — Thu., May 16, 6:52:41.1pm ET