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111, Inc. – ‘20-F’ for 12/31/22 – ‘EX-101.SCH’

On:  Friday, 4/28/23, at 6:18am ET   ·   For:  12/31/22   ·   Accession #:  1104659-23-51944   ·   File #:  1-38639

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  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 4/28/23  111, Inc.                         20-F       12/31/22  109:13M                                    Toppan Merrill/FA

Annual or Annual-Transition Report by a Foreign Non-Canadian Issuer   —   Form 20-F   —   SEA’34

Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 20-F        Annual or Annual-Transition Report by a Foreign     HTML   3.82M 
                Non-Canadian Issuer                                              
 2: EX-8.1      Opinion of Counsel re: Tax Matters                  HTML     34K 
 5: EX-13.1     Annual or Quarterly Report to Security Holders      HTML     31K 
 6: EX-13.2     Annual or Quarterly Report to Security Holders      HTML     31K 
 3: EX-12.1     Statement re: the Computation of Ratios             HTML     34K 
 4: EX-12.2     Statement re: the Computation of Ratios             HTML     35K 
 7: EX-15.1     Letter re: Unaudited Interim Financial Info         HTML     31K 
 8: EX-15.2     Letter re: Unaudited Interim Financial Info         HTML     29K 
 9: EX-15.3     Letter re: Unaudited Interim Financial Info         HTML     31K 
10: EX-16.1     Letter re: a Change in Accountant                   HTML     36K 
16: R1          Document and Entity Information                     HTML    111K 
17: R2          Consolidated Balance Sheets                         HTML    159K 
18: R3          Consolidated Balance Sheets (Parenthetical)         HTML     43K 
19: R4          Consolidated Statements of Comprehensive Loss       HTML    135K 
20: R5          Consolidated Statements of Comprehensive Loss       HTML     32K 
                (Parenthetical)                                                  
21: R6          Consolidated Statements of Changes in               HTML    117K 
                Shareholders' Equity (Deficit)                                   
22: R7          Consolidated Statements of Cash Flows               HTML    162K 
23: R8          Organization and Principal Activities               HTML     55K 
24: R9          Summary of Principal Accounting Policies            HTML    243K 
25: R10         Short-Term Investments                              HTML     38K 
26: R11         Notes Receivable                                    HTML     32K 
27: R12         Inventories                                         HTML     37K 
28: R13         Prepayments and Other Current Assets                HTML     46K 
29: R14         Leases                                              HTML     52K 
30: R15         Short-Term Borrowings                               HTML     37K 
31: R16         Accrued Expenses and Other Current Liabilities      HTML     53K 
32: R17         Redeemable Non-Controlling Interests                HTML     43K 
33: R18         Non-Controlling Interests                           HTML     34K 
34: R19         Ordinary Shares                                     HTML     39K 
35: R20         Net Revenues                                        HTML     64K 
36: R21         Share-Based Compensation                            HTML    155K 
37: R22         Loss Per Share                                      HTML     52K 
38: R23         Income Tax Expense                                  HTML     69K 
39: R24         Mainland China Contribution Plan                    HTML     33K 
40: R25         Restricted Net Assets                               HTML     33K 
41: R26         Commitments and Contingencies                       HTML     33K 
42: R27         Subsequent Events                                   HTML     33K 
43: R28         Additional Financial Information- Financial         HTML    193K 
                Statements Schedule I                                            
44: R29         Summary of Principal Accounting Policies            HTML    322K 
                (Policies)                                                       
45: R30         Organization and Principal Activities (Tables)      HTML     52K 
46: R31         Summary of Principal Accounting Policies (Tables)   HTML    157K 
47: R32         Short-Term Investments (Tables)                     HTML     37K 
48: R33         Inventories (Tables)                                HTML     38K 
49: R34         Prepayments and Other Current Assets (Tables)       HTML     46K 
50: R35         Leases (Tables)                                     HTML     50K 
51: R36         Accrued Expenses and Other Current Liabilities      HTML     52K 
                (Tables)                                                         
52: R37         Redeemable Non-Controlling Interests (Tables)       HTML     41K 
53: R38         Net Revenues (Tables)                               HTML     61K 
54: R39         Share-Based Compensation (Tables)                   HTML    148K 
55: R40         Loss Per Share (Tables)                             HTML     52K 
56: R41         Income Tax Expense (Tables)                         HTML     63K 
57: R42         Organization and Principal Activities (Details)     HTML     52K 
58: R43         SUMMARY OF PRINCIPAL ACCOUNTING POLICIES - Basis    HTML     40K 
                of presentation (Details)                                        
59: R44         SUMMARY OF PRINCIPAL ACCOUNTING POLICIES - Basis    HTML     66K 
                of consolidation (Details)                                       
60: R45         SUMMARY OF PRINCIPAL ACCOUNTING POLICIES -          HTML    129K 
                Balances of the VIEs and Short-term investments                  
                (Details)                                                        
61: R46         SUMMARY OF PRINCIPAL ACCOUNTING POLICIES -          HTML     37K 
                Accounts receivable net (Details)                                
62: R47         SUMMARY OF PRINCIPAL ACCOUNTING POLICIES -          HTML     50K 
                Property and equipment (Details)                                 
63: R48         SUMMARY OF PRINCIPAL ACCOUNTING POLICIES -          HTML     41K 
                Intangible assets and Impairment of long-lived                   
                assets (Details)                                                 
64: R49         SUMMARY OF PRINCIPAL ACCOUNTING POLICIES - Product  HTML     42K 
                revenues and Service revenues (Details)                          
65: R50         SUMMARY OF PRINCIPAL ACCOUNTING POLICIES - Selling  HTML     44K 
                and marketing expenses and Others (Details)                      
66: R51         SUMMARY OF PRINCIPAL ACCOUNTING POLICIES -          HTML     35K 
                Concentration of credit risk (Details)                           
67: R52         SUMMARY OF PRINCIPAL ACCOUNTING POLICIES - Fair     HTML     46K 
                value (Details)                                                  
68: R53         SUMMARY OF PRINCIPAL ACCOUNTING POLICIES -          HTML     37K 
                Treasury shares (Details)                                        
69: R54         SUMMARY OF PRINCIPAL ACCOUNTING POLICIES - Product  HTML     67K 
                revenues and segment profit (Loss) (Details)                     
70: R55         SUMMARY OF PRINCIPAL ACCOUNTING POLICIES -          HTML     65K 
                Reconciliation of reportable segment revenues                    
                (Details)                                                        
71: R56         SUMMARY OF PRINCIPAL ACCOUNTING POLICIES -          HTML     53K 
                Revenues from different product groups and                       
                services (Details)                                               
72: R57         SUMMARY OF PRINCIPAL ACCOUNTING POLICIES - Leases   HTML     35K 
                and Convenience translation (Details)                            
73: R58         SUMMARY OF PRINCIPAL ACCOUNTING POLICIES -          HTML     51K 
                Structured payment arrangement (Details)                         
74: R59         Short-Term Investments (Details)                    HTML     43K 
75: R60         Notes Receivable (Details)                          HTML     40K 
76: R61         Inventories (Details)                               HTML     34K 
77: R62         Prepayments and Other Current Assets (Details)      HTML     48K 
78: R63         Leases (Details)                                    HTML     74K 
79: R64         Short-Term Borrowings (Details)                     HTML    117K 
80: R65         Accrued Expenses and Other Current Liabilities      HTML     57K 
                (Details)                                                        
81: R66         Redeemable Non-Controlling Interests (Details)      HTML     58K 
82: R67         Non-Controlling Interests (Details)                 HTML     55K 
83: R68         Ordinary Shares (Details)                           HTML     73K 
84: R69         NET REVENUES - Disaggregation of revenues           HTML     49K 
                (Details)                                                        
85: R70         NET REVENUES - Contract balance (Details)           HTML     48K 
86: R71         NET REVENUES - Additional information (Details)     HTML     36K 
87: R72         Share-Based Compensation (Details)                  HTML     73K 
88: R73         Share-Based Compensation - Non-Employee Share       HTML     67K 
                Options (Details)                                                
89: R74         SHARE-BASED COMPENSATION - Assumptions used to      HTML     53K 
                estimate the fair values of the share options                    
                granted (Details)                                                
90: R75         SHARE-BASED COMPENSATION - Employee and             HTML    104K 
                Non-Employee Share Options Activity (Details)                    
91: R76         SHARE-BASED COMPENSATION - Restricted Share Units   HTML     97K 
                and Employee ownership plan (Details)                            
92: R77         SHARE-BASED COMPENSATION - Employee ownership plan  HTML     67K 
                of Yaofang (Details)                                             
93: R78         SHARE-BASED COMPENSATION - Share-based              HTML     39K 
                compensation for all share options and restricted                
                share units (Details)                                            
94: R79         LOSS PER SHARE - Computation of basic and diluted   HTML     54K 
                loss per share (Details)                                         
95: R80         LOSS PER SHARE - Share options and restricted       HTML     34K 
                share units outstanding excluded from calculation                
                of diluted loss per share (Details)                              
96: R81         Income Tax Expense (Details)                        HTML     56K 
97: R82         Income Tax Expense - Principal components of        HTML     53K 
                deferred income tax assets and liabilities                       
                (Details)                                                        
98: R83         Mainland China Contribution Plan (Details)          HTML     31K 
99: R84         Restricted Net Assets (Details)                     HTML     37K 
100: R85         Subsequent Events (Details)                         HTML     34K  
101: R86         Additional Financial Information - Financial        HTML    110K  
                Statements Schedule I - Balance Sheets (Details)                 
102: R87         Additional Financial Information - Financial        HTML     76K  
                Statements Schedule I - Statements of                            
                Comprehensive Loss (Details)                                     
103: R88         Additional Financial Information - Financial        HTML     32K  
                Statements Schedule I - Statements of                            
                Comprehensive Loss - Additional Information                      
                (Details)                                                        
104: R89         Additional Financial Information - Financial        HTML     92K  
                Statements Schedule I - Statements of Cash Flows                 
                (Details)                                                        
107: XML         IDEA XML File -- Filing Summary                      XML    200K  
105: XML         XBRL Instance -- yi-20221231x20f_htm                 XML   2.80M  
106: EXCEL       IDEA Workbook of Financial Reports                  XLSX    221K  
13: EX-101.CAL  XBRL Calculations -- yi-20221231_cal                 XML    228K 
14: EX-101.DEF  XBRL Definitions -- yi-20221231_def                  XML    969K 
15: EX-101.LAB  XBRL Labels -- yi-20221231_lab                       XML   1.79M 
11: EX-101.PRE  XBRL Presentations -- yi-20221231_pre                XML   1.45M 
12: EX-101.SCH  XBRL Schema -- yi-20221231                           XSD    247K 
108: JSON        XBRL Instance as JSON Data -- MetaLinks              537±   872K  
109: ZIP         XBRL Zipped Folder -- 0001104659-23-051944-xbrl      Zip    990K

‘EX-101.SCH’   —   XBRL Schema — yi-20221231

This Exhibit is an XBRL XML File.

                                                                                                                                                                                
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<!-- Modified on: 4/28/2023 9:59:27 AM -->
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<link:definition> 99900 - Disclosure - Standard And Custom Axis Domain Defaults </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
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<link:roleType roleURI="http://www.111.com.cn/role/StatementConsolidatedBalanceSheets" id="StatementConsolidatedBalanceSheets">
<link:definition> 00100 - Statement - CONSOLIDATED BALANCE SHEETS </link:definition>
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<link:roleType roleURI="http://www.111.com.cn/role/StatementConsolidatedStatementsOfComprehensiveLoss" id="StatementConsolidatedStatementsOfComprehensiveLoss">
<link:definition> 00200 - Statement - CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType roleURI="http://www.111.com.cn/role/StatementConsolidatedStatementsOfCashFlows" id="StatementConsolidatedStatementsOfCashFlows">
<link:definition> 00400 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:definition> 40212 - Disclosure - SUMMARY OF PRINCIPAL ACCOUNTING POLICIES - Product revenues and segment profit (loss) (Details) </link:definition>
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<link:definition> 40213 - Disclosure - SUMMARY OF PRINCIPAL ACCOUNTING POLICIES - Reconciliation of reportable segment revenues (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
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<link:roleType roleURI="http://www.111.com.cn/role/DisclosurePrepaymentsAndOtherCurrentAssetsDetails" id="DisclosurePrepaymentsAndOtherCurrentAssetsDetails">
<link:definition> 40601 - Disclosure - PREPAYMENTS AND OTHER CURRENT ASSETS (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.111.com.cn/role/DisclosureLeasesDetails" id="DisclosureLeasesDetails">
<link:definition> 40701 - Disclosure - LEASES (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType roleURI="http://www.111.com.cn/role/DisclosureAccruedExpensesAndOtherCurrentLiabilitiesDetails" id="DisclosureAccruedExpensesAndOtherCurrentLiabilitiesDetails">
<link:definition> 40901 - Disclosure - ACCRUED EXPENSES AND OTHER CURRENT LIABILITIES (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
</link:roleType>
<link:roleType roleURI="http://www.111.com.cn/role/DisclosureLeasesDetailsCalc2" id="DisclosureLeasesDetailsCalc2">
<link:definition> 409011 - Disclosure - LEASES (Details) - Calc 2 </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:roleType roleURI="http://www.111.com.cn/role/DisclosureIncomeTaxExpenseDetails" id="DisclosureIncomeTaxExpenseDetails">
<link:definition> 41601 - Disclosure - INCOME TAX EXPENSE (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
<link:usedOn> link:definitionLink </link:usedOn>
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<link:definition> 41602 - Disclosure - INCOME TAX EXPENSE - Principal components of deferred income tax assets and liabilities (Details) </link:definition>
<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
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<link:usedOn> link:presentationLink </link:usedOn>
<link:usedOn> link:calculationLink </link:usedOn>
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<link:definition> 00105 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical) </link:definition>
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<link:usedOn> link:calculationLink </link:usedOn>
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<link:definition> 00205 - Statement - CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS (Parenthetical) </link:definition>
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<link:definition> 00300 - Statement - CONSOLIDATED STATEMENTS OF CHANGES IN SHAREHOLDERS' EQUITY (DEFICIT) </link:definition>
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<link:definition> 31403 - Disclosure - SHARE-BASED COMPENSATION (Tables) </link:definition>
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<link:definition> 40101 - Disclosure - ORGANIZATION AND PRINCIPAL ACTIVITIES (Details) </link:definition>
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<link:definition> 40202 - Disclosure - SUMMARY OF PRINCIPAL ACCOUNTING POLICIES - Basis of consolidation (Details) </link:definition>
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<link:definition> 40203 - Disclosure - SUMMARY OF PRINCIPAL ACCOUNTING POLICIES - Balances of the VIEs and Short-term investments (Details) </link:definition>
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<link:definition> 40208 - Disclosure - SUMMARY OF PRINCIPAL ACCOUNTING POLICIES - Selling and marketing expenses and Others (Details) </link:definition>
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<xsd:element id="yi_AmericanDepositaryShareMember" name="AmericanDepositaryShareMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration"/>
<xsd:element id="yi_ProceedsFromRedeemableNonControllingInterestEquityCommonShareHolders" name="ProceedsFromRedeemableNonControllingInterestEquityCommonShareHolders" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit"/>
<xsd:element id="yi_PaymentForOtherFinancingActivities" name="PaymentForOtherFinancingActivities" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit"/>
<xsd:element id="yi_ShanxiYaofangPharmacyCoLtdMember" name="ShanxiYaofangPharmacyCoLtdMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration"/>
<xsd:element id="yi_LiaoningYaofangPharmacyCoLtdMember" name="LiaoningYaofangPharmacyCoLtdMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration"/>
<xsd:element id="yi_NonControllingInterestsPolicyTextBlock" name="NonControllingInterestsPolicyTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration"/>
<xsd:element id="yi_RedeemableNonControllingInterestsDisclosureTextBlock" name="RedeemableNonControllingInterestsDisclosureTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration"/>
<xsd:element id="yi_YaofangMember" name="YaofangMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration"/>
<xsd:element id="yi_PercentageOfTemporaryOrdinarySharesIssuedToPrivatePlacementInvestors" name="PercentageOfTemporaryOrdinarySharesIssuedToPrivatePlacementInvestors" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration"/>
<xsd:element id="yi_AnnualInterestRate" name="AnnualInterestRate" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration"/>
<xsd:element id="yi_MovementInRedeemableMinorityInterestNumberOfSharesRollForward" name="MovementInRedeemableMinorityInterestNumberOfSharesRollForward" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration"/>
<xsd:element id="yi_TemporaryEquityStockIncludingPortionAttributableToNonControllingInterests" name="TemporaryEquityStockIncludingPortionAttributableToNonControllingInterests" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant"/>
<xsd:element id="yi_VestingWithinTwoYearsMember" name="VestingWithinTwoYearsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration"/>
<xsd:element id="yi_VestingOverTwoYearsThereafterMember" name="VestingOverTwoYearsThereafterMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration"/>
<xsd:element id="yi_CapitalContributionFromNonControllingShareholders" name="CapitalContributionFromNonControllingShareholders" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit"/>
<xsd:element id="yi_ShareOptionsAndRestrictedShareUnitsMember" name="ShareOptionsAndRestrictedShareUnitsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration"/>
<xsd:element id="yi_EmployeeOwnershipPlanOfYaofangMember" name="EmployeeOwnershipPlanOfYaofangMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration"/>
<xsd:element id="yi_FairValueOfOrdinaryShares" name="FairValueOfOrdinaryShares" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant"/>
<xsd:element id="yi_ChinaMerchantBankMember" name="ChinaMerchantBankMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration"/>
<xsd:element id="yi_IndustrialBankMember" name="IndustrialBankMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration"/>
<xsd:element id="yi_ShanghaiPudongTechnologyFinancialServiceCo.Ltd.Member" name="ShanghaiPudongTechnologyFinancialServiceCo.Ltd.Member" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration"/>
<xsd:element id="yi_ChinaConstructionBankMember" name="ChinaConstructionBankMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration"/>
<xsd:element id="yi_DebtToAssetRatio" name="DebtToAssetRatio" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration"/>
<xsd:element id="yi_LiquidityRatio" name="LiquidityRatio" nillable="true" type="xbrli:pureItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration"/>
<xsd:element id="yi_SeveralOtherFinancialInstitutionsMember" name="SeveralOtherFinancialInstitutionsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration"/>
<xsd:element id="yi_ExchangeTradedFundProductsAndWealthManagementProductsMember" name="ExchangeTradedFundProductsAndWealthManagementProductsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration"/>
<xsd:element id="yi_NumberOfPharmacy" name="NumberOfPharmacy" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant"/>
<xsd:element id="yi_NumberOfMedicineMarketplaces" name="NumberOfMedicineMarketplaces" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant"/>
<xsd:element id="yi_DeferredTaxAssetsProvisionForImpairmentOfAssets" name="DeferredTaxAssetsProvisionForImpairmentOfAssets" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit"/>
<xsd:element id="yi_IncreaseDecreaseInAccountsReceivableExcludingCreditLoss" name="IncreaseDecreaseInAccountsReceivableExcludingCreditLoss" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit"/>
<xsd:element id="yi_AccountsReceivableAndOtherReceivablesCreditLossExpenseReversal" name="AccountsReceivableAndOtherReceivablesCreditLossExpenseReversal" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit"/>
<xsd:element id="yi_ReconciliationOfCashCashEquivalentsAndRestrictedCashAbstract" name="ReconciliationOfCashCashEquivalentsAndRestrictedCashAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration"/>
<xsd:element id="yi_FulfillmentExpenses" name="FulfillmentExpenses" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit"/>
<xsd:element id="yi_ScheduleOfWeightedAverageRemainingLeaseTermsAndWeightedAverageDiscountRatesLeasesTableTextBlock" name="ScheduleOfWeightedAverageRemainingLeaseTermsAndWeightedAverageDiscountRatesLeasesTableTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration"/>
<xsd:element name="NetIncomeLossAttributableToAdjustmentAttributableToRedeemableNonControllingInterest" id="yi_NetIncomeLossAttributableToAdjustmentAttributableToRedeemableNonControllingInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit"/>
<xsd:element name="WithholdingIncomeTaxOnUndistributedProfits" id="yi_WithholdingIncomeTaxOnUndistributedProfits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit"/>
<xsd:element name="IncreaseDecreaseRightOfUseAssetDueToLeaseModification" id="yi_IncreaseDecreaseRightOfUseAssetDueToLeaseModification" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit"/>
<xsd:element name="ImpairmentRecognizedForNonFinancialAssets" id="yi_ImpairmentRecognizedForNonFinancialAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit"/>
<xsd:element name="LiabilityUnderReverseFactoringProgramCurrent" id="yi_LiabilityUnderReverseFactoringProgramCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit"/>
<xsd:element name="StructuredPaymentArrangementPolicyTextBlock" id="yi_StructuredPaymentArrangementPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false"/>
<xsd:element name="NumberOfDaysForRepaymentOfSettlementProceeds" id="yi_NumberOfDaysForRepaymentOfSettlementProceeds" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false"/>
<xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionContractualLifeOfOption" id="yi_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionContractualLifeOfOption" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false"/>
<xsd:element name="IncomeTaxesAbstract" id="yi_IncomeTaxesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true"/>
<xsd:element name="EarningLossPerShareBasicAndDilutedOtherDisclosuresAbstract" id="yi_EarningLossPerShareBasicAndDilutedOtherDisclosuresAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true"/>
<xsd:element name="SignificantAccountingPoliciesTable" id="yi_SignificantAccountingPoliciesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" nillable="true" xbrli:periodType="duration" abstract="true"/>
<xsd:element name="SignificantAccountingPoliciesLineItems" id="yi_SignificantAccountingPoliciesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true"/>
<xsd:element name="TemporaryEquityNumberOfSharesIncreased" id="yi_TemporaryEquityNumberOfSharesIncreased" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false"/>
<xsd:element name="CommonStockValueAuthorized" id="yi_CommonStockValueAuthorized" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit"/>
<xsd:element name="GuangdongYihaoPharmacyCo.LtdMember" id="yi_GuangdongYihaoPharmacyCo.LtdMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true"/>
<xsd:element name="GuangdongYihaoPharmaceuticalChainCo.LtdMember" id="yi_GuangdongYihaoPharmaceuticalChainCo.LtdMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true"/>
<xsd:element name="ChongquingYihaoPharmacyCo.LtdMember" id="yi_ChongquingYihaoPharmacyCo.LtdMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true"/>
<xsd:element name="TianjinYihaoPharmacyCo.LtdMember" id="yi_TianjinYihaoPharmacyCo.LtdMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true"/>
<xsd:element name="KunshanYifangPharmacyCo.LtdMember" id="yi_KunshanYifangPharmacyCo.LtdMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true"/>
<xsd:element name="HubeiYihaoPharmacyCo.LtdMember" id="yi_HubeiYihaoPharmacyCo.LtdMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true"/>
<xsd:element name="PaymentOfVieReorganization" id="yi_PaymentOfVieReorganization" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit"/>
<xsd:element name="LiabilityUnderFactoringProgramCurrent" id="yi_LiabilityUnderFactoringProgramCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit"/>
<xsd:element name="CashPaidByCustomerButHeldByThirdPartyCompanies" id="yi_CashPaidByCustomerButHeldByThirdPartyCompanies" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit"/>
<xsd:element name="NetIncomeLossAttributableToRedeemablesNoncontrollingInterests" id="yi_NetIncomeLossAttributableToRedeemablesNoncontrollingInterests" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit"/>
<xsd:element name="YihaoPharmaceuticalChainMember" id="yi_YihaoPharmaceuticalChainMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true"/>
<xsd:element name="MaximumPercentageOfHoldingOfEquityInterestsOfForeignInvestedTelecommunicationsEnterprisesIfThoseBusinessAreInECommerce" id="yi_MaximumPercentageOfHoldingOfEquityInterestsOfForeignInvestedTelecommunicationsEnterprisesIfThoseBusinessAreInECommerce" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false"/>
<xsd:element name="PercentageOfEquityHeldInEnterprisesWhichHaveECommerceBusiness" id="yi_PercentageOfEquityHeldInEnterprisesWhichHaveECommerceBusiness" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false"/>
<xsd:element name="PercentageOfContributionToConsolidatedTotalAssets" id="yi_PercentageOfContributionToConsolidatedTotalAssets" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false"/>
<xsd:element name="PercentageOfContributionToConsolidatedTotalLiabilities" id="yi_PercentageOfContributionToConsolidatedTotalLiabilities" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false"/>
<xsd:element name="PercentageOfContributionToConsolidatedRevenue" id="yi_PercentageOfContributionToConsolidatedRevenue" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false"/>
<xsd:element name="PercentageOfContributionToConsolidatedOperatingCashFlow" id="yi_PercentageOfContributionToConsolidatedOperatingCashFlow" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false"/>
<xsd:element name="PercentageOfContributionToConsolidatedInvestingCashFlow" id="yi_PercentageOfContributionToConsolidatedInvestingCashFlow" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false"/>
<xsd:element name="PercentageOfContributionToConsolidatedFinancingCashFlow" id="yi_PercentageOfContributionToConsolidatedFinancingCashFlow" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false"/>
<xsd:element name="PersonalReimbursementCurrent" id="yi_PersonalReimbursementCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit"/>
<xsd:element name="IncomeLossFromSubsidiariesAndShareOfLossInFormerVariableIntertestEntities" id="yi_IncomeLossFromSubsidiariesAndShareOfLossInFormerVariableIntertestEntities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit"/>
<xsd:element name="FormerVariableInterestEntityAndItsSubsidiariesMember" id="yi_FormerVariableInterestEntityAndItsSubsidiariesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true"/>
<xsd:element name="NumberOfGranteesAffectedForIncrementalCost" id="yi_NumberOfGranteesAffectedForIncrementalCost" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false"/>
<xsd:element name="FactoringProgramProceedsObtainedForSettlement" id="yi_FactoringProgramProceedsObtainedForSettlement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit"/>
<xsd:element name="FactoringProgramRepaymentsMade" id="yi_FactoringProgramRepaymentsMade" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit"/>
<xsd:element name="NumberOfDaysForFactoringProgramRepaymentOfSettlementProceeds" id="yi_NumberOfDaysForFactoringProgramRepaymentOfSettlementProceeds" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false"/>
<xsd:element name="OneInvestorMember" id="yi_OneInvestorMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true"/>
</xsd:schema>

2 Subsequent Filings that Reference this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 8/14/23  SEC                               UPLOAD9/12/23    2:39K  111, Inc.
 7/21/23  SEC                               UPLOAD9/12/23    2:47K  111, Inc.

5 Previous Filings that this Filing References

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 4/30/21  111, Inc.                         20-F       12/31/20  119:15M                                    Toppan Merrill/FA
 4/16/20  111, Inc.                         20-F       12/31/19  116:12M                                    Toppan Merrill/FA
 1/22/19  111, Inc.                         S-8         1/22/19    4:593K                                   Toppan Merrill/FA
 8/29/18  111, Inc.                         F-1/A                 13:5.9M                                   Toppan Merrill-FA
 8/15/18  111, Inc.                         F-1                   26:7.9M                                   Toppan Merrill-FA
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