| | | | | | | | | | | | | | | | | | | | | |
<?xml version="1.0" encoding="windows-1252"?> |
<xbrl xml:lang="en-US" xmlns="http://www.xbrl.org/2003/instance" xmlns:dei="http://xbrl.sec.gov/dei/2020-01-31" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink"> |
| <link:schemaRef xlink:href="exel-20210225.xsd" xlink:type="simple"/> |
| <context id="i21806cf0ba0346ca8eaea1ef840cc405_D20210303-20210303"> |
| | <entity> |
| | | <identifier scheme="http://www.sec.gov/CIK"> 0000939767 </identifier> |
| | | </entity> |
| | <period> |
| | | <startDate> 2021-03-03 </startDate> |
| | | <endDate> 2021-03-03 </endDate> |
| | | </period> |
| | </context> |
| <dei:DocumentPeriodEndDate contextRef="i21806cf0ba0346ca8eaea1ef840cc405_D20210303-20210303" id="id3VybDovL2RvY3MudjEvZG9jOjk3MjU2YWVkYzUwNjQ3ODU4Mjc1YjA4MTYyMTUwZjU2L3NlYzo5NzI1NmFlZGM1MDY0Nzg1ODI3NWIwODE2MjE1MGY1Nl80L2ZyYWc6OWJlMzcwNDhjYWNiNGJlODgxNjQ1YTM5NzI0YjdjYzYvdGFibGU6Yzk5OGIzMjZlMmU3NGEzZGJhOWJhOGIzYzc0OWI5OTAvdGFibGVyYW5nZTpjOTk4YjMyNmUyZTc0YTNkYmE5YmE4YjNjNzQ5Yjk5MF8xLTEtMS0xLTA_6b48d1db-e564-4175-be43-9ef3fc3e6812"> 2021-02-25 </dei:DocumentPeriodEndDate> |
| <dei:EntityCentralIndexKey contextRef="i21806cf0ba0346ca8eaea1ef840cc405_D20210303-20210303" id="id3VybDovL2RvY3MudjEvZG9jOjk3MjU2YWVkYzUwNjQ3ODU4Mjc1YjA4MTYyMTUwZjU2L3NlYzo5NzI1NmFlZGM1MDY0Nzg1ODI3NWIwODE2MjE1MGY1Nl80L2ZyYWc6OWJlMzcwNDhjYWNiNGJlODgxNjQ1YTM5NzI0YjdjYzYvdGFibGU6Yzk5OGIzMjZlMmU3NGEzZGJhOWJhOGIzYzc0OWI5OTAvdGFibGVyYW5nZTpjOTk4YjMyNmUyZTc0YTNkYmE5YmE4YjNjNzQ5Yjk5MF8yLTEtMS0xLTA_bf29235c-6c62-485d-8f43-22f4af322712"> 0000939767 </dei:EntityCentralIndexKey> |
| <dei:AmendmentFlag contextRef="i21806cf0ba0346ca8eaea1ef840cc405_D20210303-20210303" id="id3VybDovL2RvY3MudjEvZG9jOjk3MjU2YWVkYzUwNjQ3ODU4Mjc1YjA4MTYyMTUwZjU2L3NlYzo5NzI1NmFlZGM1MDY0Nzg1ODI3NWIwODE2MjE1MGY1Nl80L2ZyYWc6OWJlMzcwNDhjYWNiNGJlODgxNjQ1YTM5NzI0YjdjYzYvdGFibGU6Yzk5OGIzMjZlMmU3NGEzZGJhOWJhOGIzYzc0OWI5OTAvdGFibGVyYW5nZTpjOTk4YjMyNmUyZTc0YTNkYmE5YmE4YjNjNzQ5Yjk5MF81LTEtMS0xLTA_0f00e079-3315-4aea-8b8b-46b50e61ab1c"> false </dei:AmendmentFlag> |
| <dei:CurrentFiscalYearEndDate contextRef="i21806cf0ba0346ca8eaea1ef840cc405_D20210303-20210303" id="id3VybDovL2RvY3MudjEvZG9jOjk3MjU2YWVkYzUwNjQ3ODU4Mjc1YjA4MTYyMTUwZjU2L3NlYzo5NzI1NmFlZGM1MDY0Nzg1ODI3NWIwODE2MjE1MGY1Nl80L2ZyYWc6OWJlMzcwNDhjYWNiNGJlODgxNjQ1YTM5NzI0YjdjYzYvdGFibGU6Yzk5OGIzMjZlMmU3NGEzZGJhOWJhOGIzYzc0OWI5OTAvdGFibGVyYW5nZTpjOTk4YjMyNmUyZTc0YTNkYmE5YmE4YjNjNzQ5Yjk5MF82LTEtMS0xLTEwNA_2a3b2dc1-5bfb-41cf-9191-d14d6281b4cd"> --12-31 </dei:CurrentFiscalYearEndDate> |
| <dei:DocumentType contextRef="i21806cf0ba0346ca8eaea1ef840cc405_D20210303-20210303" id="id3VybDovL2RvY3MudjEvZG9jOjk3MjU2YWVkYzUwNjQ3ODU4Mjc1YjA4MTYyMTUwZjU2L3NlYzo5NzI1NmFlZGM1MDY0Nzg1ODI3NWIwODE2MjE1MGY1Nl8xL2ZyYWc6MTI0M2Q5ZjEwNzEwNGJiMTk1YWRiZTEzODVlN2E5YTUvdGFibGU6YmQ4YzRhYmQ1MjMzNGQxNDlmMmI5ZmRhYTQ1ZDc1ODUvdGFibGVyYW5nZTpiZDhjNGFiZDUyMzM0ZDE0OWYyYjlmZGFhNDVkNzU4NV8wLTEtMS0xLTA_393189e4-b2fe-4c7b-b5ca-28be9db46a40"> 8-K </dei:DocumentType> |
| <dei:DocumentPeriodEndDate contextRef="i21806cf0ba0346ca8eaea1ef840cc405_D20210303-20210303" id="id3VybDovL2RvY3MudjEvZG9jOjk3MjU2YWVkYzUwNjQ3ODU4Mjc1YjA4MTYyMTUwZjU2L3NlYzo5NzI1NmFlZGM1MDY0Nzg1ODI3NWIwODE2MjE1MGY1Nl8xL2ZyYWc6MTI0M2Q5ZjEwNzEwNGJiMTk1YWRiZTEzODVlN2E5YTUvdGV4dHJlZ2lvbjoxMjQzZDlmMTA3MTA0YmIxOTVhZGJlMTM4NWU3YTlhNV8xMDk5NTExNjI5NDI4_6b48d1db-e564-4175-be43-9ef3fc3e6812"> 2021-02-25 </dei:DocumentPeriodEndDate> |
| <dei:EntityRegistrantName contextRef="i21806cf0ba0346ca8eaea1ef840cc405_D20210303-20210303" id="id3VybDovL2RvY3MudjEvZG9jOjk3MjU2YWVkYzUwNjQ3ODU4Mjc1YjA4MTYyMTUwZjU2L3NlYzo5NzI1NmFlZGM1MDY0Nzg1ODI3NWIwODE2MjE1MGY1Nl8xL2ZyYWc6MTI0M2Q5ZjEwNzEwNGJiMTk1YWRiZTEzODVlN2E5YTUvdGFibGU6ZmZmMDk3NzVkZWYwNDQ0ODkxOTA0OWMwZTAwYjc2NWYvdGFibGVyYW5nZTpmZmYwOTc3NWRlZjA0NDQ4OTE5MDQ5YzBlMDBiNzY1Zl8xLTAtMS0xLTA_c0d9d434-6f66-4e2d-8cda-23442150e227"> EXELIXIS, INC. </dei:EntityRegistrantName> |
| <dei:EntityIncorporationStateCountryCode contextRef="i21806cf0ba0346ca8eaea1ef840cc405_D20210303-20210303" id="id3VybDovL2RvY3MudjEvZG9jOjk3MjU2YWVkYzUwNjQ3ODU4Mjc1YjA4MTYyMTUwZjU2L3NlYzo5NzI1NmFlZGM1MDY0Nzg1ODI3NWIwODE2MjE1MGY1Nl8xL2ZyYWc6MTI0M2Q5ZjEwNzEwNGJiMTk1YWRiZTEzODVlN2E5YTUvdGFibGU6MjBjZGRmYzY5OGI5NGQ1MDk4YjVhZWVkNzYyOTJhY2YvdGFibGVyYW5nZToyMGNkZGZjNjk4Yjk0ZDUwOThiNWFlZWQ3NjI5MmFjZl8wLTAtMS0xLTA_d2f9973d-b718-44ea-a09f-093e4a8dad18"> DE </dei:EntityIncorporationStateCountryCode> |
| <dei:EntityFileNumber contextRef="i21806cf0ba0346ca8eaea1ef840cc405_D20210303-20210303" id="id3VybDovL2RvY3MudjEvZG9jOjk3MjU2YWVkYzUwNjQ3ODU4Mjc1YjA4MTYyMTUwZjU2L3NlYzo5NzI1NmFlZGM1MDY0Nzg1ODI3NWIwODE2MjE1MGY1Nl8xL2ZyYWc6MTI0M2Q5ZjEwNzEwNGJiMTk1YWRiZTEzODVlN2E5YTUvdGFibGU6MjBjZGRmYzY5OGI5NGQ1MDk4YjVhZWVkNzYyOTJhY2YvdGFibGVyYW5nZToyMGNkZGZjNjk4Yjk0ZDUwOThiNWFlZWQ3NjI5MmFjZl8wLTEtMS0xLTA_acdb5d61-f7e5-459f-abfd-6b1f16c88808"> 000-30235 </dei:EntityFileNumber> |
| <dei:EntityTaxIdentificationNumber contextRef="i21806cf0ba0346ca8eaea1ef840cc405_D20210303-20210303" id="id3VybDovL2RvY3MudjEvZG9jOjk3MjU2YWVkYzUwNjQ3ODU4Mjc1YjA4MTYyMTUwZjU2L3NlYzo5NzI1NmFlZGM1MDY0Nzg1ODI3NWIwODE2MjE1MGY1Nl8xL2ZyYWc6MTI0M2Q5ZjEwNzEwNGJiMTk1YWRiZTEzODVlN2E5YTUvdGFibGU6MjBjZGRmYzY5OGI5NGQ1MDk4YjVhZWVkNzYyOTJhY2YvdGFibGVyYW5nZToyMGNkZGZjNjk4Yjk0ZDUwOThiNWFlZWQ3NjI5MmFjZl8wLTItMS0xLTA_d5daff21-6fcb-4355-be21-39cbf65ab282"> 04-3257395 </dei:EntityTaxIdentificationNumber> |
| <dei:EntityAddressAddressLine1 contextRef="i21806cf0ba0346ca8eaea1ef840cc405_D20210303-20210303" id="id3VybDovL2RvY3MudjEvZG9jOjk3MjU2YWVkYzUwNjQ3ODU4Mjc1YjA4MTYyMTUwZjU2L3NlYzo5NzI1NmFlZGM1MDY0Nzg1ODI3NWIwODE2MjE1MGY1Nl8xL2ZyYWc6MTI0M2Q5ZjEwNzEwNGJiMTk1YWRiZTEzODVlN2E5YTUvdGV4dHJlZ2lvbjoxMjQzZDlmMTA3MTA0YmIxOTVhZGJlMTM4NWU3YTlhNV8xNTk4_3334676c-2868-4f48-b7e0-9b981505bb27"> 1851 Harbor Bay Parkway </dei:EntityAddressAddressLine1> |
| <dei:EntityAddressCityOrTown contextRef="i21806cf0ba0346ca8eaea1ef840cc405_D20210303-20210303" id="id3VybDovL2RvY3MudjEvZG9jOjk3MjU2YWVkYzUwNjQ3ODU4Mjc1YjA4MTYyMTUwZjU2L3NlYzo5NzI1NmFlZGM1MDY0Nzg1ODI3NWIwODE2MjE1MGY1Nl8xL2ZyYWc6MTI0M2Q5ZjEwNzEwNGJiMTk1YWRiZTEzODVlN2E5YTUvdGV4dHJlZ2lvbjoxMjQzZDlmMTA3MTA0YmIxOTVhZGJlMTM4NWU3YTlhNV8xNjA2_588448cb-750e-4103-8ce0-55465e850465"> Alameda </dei:EntityAddressCityOrTown> |
| <dei:EntityAddressStateOrProvince contextRef="i21806cf0ba0346ca8eaea1ef840cc405_D20210303-20210303" id="id3VybDovL2RvY3MudjEvZG9jOjk3MjU2YWVkYzUwNjQ3ODU4Mjc1YjA4MTYyMTUwZjU2L3NlYzo5NzI1NmFlZGM1MDY0Nzg1ODI3NWIwODE2MjE1MGY1Nl8xL2ZyYWc6MTI0M2Q5ZjEwNzEwNGJiMTk1YWRiZTEzODVlN2E5YTUvdGV4dHJlZ2lvbjoxMjQzZDlmMTA3MTA0YmIxOTVhZGJlMTM4NWU3YTlhNV8xNjA3_180ed033-0046-416f-9ff0-e40969f47f09"> CA </dei:EntityAddressStateOrProvince> |
| <dei:EntityAddressPostalZipCode contextRef="i21806cf0ba0346ca8eaea1ef840cc405_D20210303-20210303" id="id3VybDovL2RvY3MudjEvZG9jOjk3MjU2YWVkYzUwNjQ3ODU4Mjc1YjA4MTYyMTUwZjU2L3NlYzo5NzI1NmFlZGM1MDY0Nzg1ODI3NWIwODE2MjE1MGY1Nl8xL2ZyYWc6MTI0M2Q5ZjEwNzEwNGJiMTk1YWRiZTEzODVlN2E5YTUvdGV4dHJlZ2lvbjoxMjQzZDlmMTA3MTA0YmIxOTVhZGJlMTM4NWU3YTlhNV8xNjAw_8f74cb3d-7433-4148-be6f-e9f0e55d0868"> 94502 </dei:EntityAddressPostalZipCode> |
| <dei:CityAreaCode contextRef="i21806cf0ba0346ca8eaea1ef840cc405_D20210303-20210303" id="id3VybDovL2RvY3MudjEvZG9jOjk3MjU2YWVkYzUwNjQ3ODU4Mjc1YjA4MTYyMTUwZjU2L3NlYzo5NzI1NmFlZGM1MDY0Nzg1ODI3NWIwODE2MjE1MGY1Nl8xL2ZyYWc6MTI0M2Q5ZjEwNzEwNGJiMTk1YWRiZTEzODVlN2E5YTUvdGV4dHJlZ2lvbjoxMjQzZDlmMTA3MTA0YmIxOTVhZGJlMTM4NWU3YTlhNV8xNTk5_c2a14d9e-05dc-4b7e-8ee6-fcc5c80f7ffc"> 650 </dei:CityAreaCode> |
| <dei:LocalPhoneNumber contextRef="i21806cf0ba0346ca8eaea1ef840cc405_D20210303-20210303" id="id3VybDovL2RvY3MudjEvZG9jOjk3MjU2YWVkYzUwNjQ3ODU4Mjc1YjA4MTYyMTUwZjU2L3NlYzo5NzI1NmFlZGM1MDY0Nzg1ODI3NWIwODE2MjE1MGY1Nl8xL2ZyYWc6MTI0M2Q5ZjEwNzEwNGJiMTk1YWRiZTEzODVlN2E5YTUvdGV4dHJlZ2lvbjoxMjQzZDlmMTA3MTA0YmIxOTVhZGJlMTM4NWU3YTlhNV8xNjAx_03c02c55-dcf4-4dc1-8f99-c4558c0d3474"> 837-7000 </dei:LocalPhoneNumber> |
| <dei:WrittenCommunications contextRef="i21806cf0ba0346ca8eaea1ef840cc405_D20210303-20210303" id="id3VybDovL2RvY3MudjEvZG9jOjk3MjU2YWVkYzUwNjQ3ODU4Mjc1YjA4MTYyMTUwZjU2L3NlYzo5NzI1NmFlZGM1MDY0Nzg1ODI3NWIwODE2MjE1MGY1Nl8xL2ZyYWc6MTI0M2Q5ZjEwNzEwNGJiMTk1YWRiZTEzODVlN2E5YTUvdGV4dHJlZ2lvbjoxMjQzZDlmMTA3MTA0YmIxOTVhZGJlMTM4NWU3YTlhNV8xNjAy_8aa1b68c-1a68-4459-ac94-8ccac3378b80"> false </dei:WrittenCommunications> |
| <dei:SolicitingMaterial contextRef="i21806cf0ba0346ca8eaea1ef840cc405_D20210303-20210303" id="id3VybDovL2RvY3MudjEvZG9jOjk3MjU2YWVkYzUwNjQ3ODU4Mjc1YjA4MTYyMTUwZjU2L3NlYzo5NzI1NmFlZGM1MDY0Nzg1ODI3NWIwODE2MjE1MGY1Nl8xL2ZyYWc6MTI0M2Q5ZjEwNzEwNGJiMTk1YWRiZTEzODVlN2E5YTUvdGV4dHJlZ2lvbjoxMjQzZDlmMTA3MTA0YmIxOTVhZGJlMTM4NWU3YTlhNV8xNjAz_7fc3250c-f40b-4d06-abd0-d9d5d118cccb"> false </dei:SolicitingMaterial> |
| <dei:PreCommencementTenderOffer contextRef="i21806cf0ba0346ca8eaea1ef840cc405_D20210303-20210303" id="id3VybDovL2RvY3MudjEvZG9jOjk3MjU2YWVkYzUwNjQ3ODU4Mjc1YjA4MTYyMTUwZjU2L3NlYzo5NzI1NmFlZGM1MDY0Nzg1ODI3NWIwODE2MjE1MGY1Nl8xL2ZyYWc6MTI0M2Q5ZjEwNzEwNGJiMTk1YWRiZTEzODVlN2E5YTUvdGV4dHJlZ2lvbjoxMjQzZDlmMTA3MTA0YmIxOTVhZGJlMTM4NWU3YTlhNV8xNTk3_79ed9211-9a96-4bd0-845a-b7db8542513a"> false </dei:PreCommencementTenderOffer> |
| <dei:PreCommencementIssuerTenderOffer contextRef="i21806cf0ba0346ca8eaea1ef840cc405_D20210303-20210303" id="id3VybDovL2RvY3MudjEvZG9jOjk3MjU2YWVkYzUwNjQ3ODU4Mjc1YjA4MTYyMTUwZjU2L3NlYzo5NzI1NmFlZGM1MDY0Nzg1ODI3NWIwODE2MjE1MGY1Nl8xL2ZyYWc6MTI0M2Q5ZjEwNzEwNGJiMTk1YWRiZTEzODVlN2E5YTUvdGV4dHJlZ2lvbjoxMjQzZDlmMTA3MTA0YmIxOTVhZGJlMTM4NWU3YTlhNV8xNjA0_2bfd244f-2297-4a81-a267-ada7c2073976"> false </dei:PreCommencementIssuerTenderOffer> |
| <dei:Security12bTitle contextRef="i21806cf0ba0346ca8eaea1ef840cc405_D20210303-20210303" id="id3VybDovL2RvY3MudjEvZG9jOjk3MjU2YWVkYzUwNjQ3ODU4Mjc1YjA4MTYyMTUwZjU2L3NlYzo5NzI1NmFlZGM1MDY0Nzg1ODI3NWIwODE2MjE1MGY1Nl8xL2ZyYWc6MTI0M2Q5ZjEwNzEwNGJiMTk1YWRiZTEzODVlN2E5YTUvdGFibGU6MWYyNmFjY2ZhZjM4NGY5NmI2MTY4NWY2MDYxZmYxNDUvdGFibGVyYW5nZToxZjI2YWNjZmFmMzg0Zjk2YjYxNjg1ZjYwNjFmZjE0NV8xLTAtMS0xLTA_bc9b29b1-cfd1-4dd3-86b5-dedd648eae01"> Common Stock $.001 Par Value per Share </dei:Security12bTitle> |
| <dei:TradingSymbol contextRef="i21806cf0ba0346ca8eaea1ef840cc405_D20210303-20210303" id="id3VybDovL2RvY3MudjEvZG9jOjk3MjU2YWVkYzUwNjQ3ODU4Mjc1YjA4MTYyMTUwZjU2L3NlYzo5NzI1NmFlZGM1MDY0Nzg1ODI3NWIwODE2MjE1MGY1Nl8xL2ZyYWc6MTI0M2Q5ZjEwNzEwNGJiMTk1YWRiZTEzODVlN2E5YTUvdGFibGU6MWYyNmFjY2ZhZjM4NGY5NmI2MTY4NWY2MDYxZmYxNDUvdGFibGVyYW5nZToxZjI2YWNjZmFmMzg0Zjk2YjYxNjg1ZjYwNjFmZjE0NV8xLTEtMS0xLTA_8cdeddee-f126-4488-96b4-11a787c65713"> EXEL </dei:TradingSymbol> |
| <dei:SecurityExchangeName contextRef="i21806cf0ba0346ca8eaea1ef840cc405_D20210303-20210303" id="id3VybDovL2RvY3MudjEvZG9jOjk3MjU2YWVkYzUwNjQ3ODU4Mjc1YjA4MTYyMTUwZjU2L3NlYzo5NzI1NmFlZGM1MDY0Nzg1ODI3NWIwODE2MjE1MGY1Nl8xL2ZyYWc6MTI0M2Q5ZjEwNzEwNGJiMTk1YWRiZTEzODVlN2E5YTUvdGFibGU6MWYyNmFjY2ZhZjM4NGY5NmI2MTY4NWY2MDYxZmYxNDUvdGFibGVyYW5nZToxZjI2YWNjZmFmMzg0Zjk2YjYxNjg1ZjYwNjFmZjE0NV8xLTItMS0xLTA_759f6776-72e9-4dfd-a3c4-cbf714bf237d"> NASDAQ </dei:SecurityExchangeName> |
| <dei:EntityEmergingGrowthCompany contextRef="i21806cf0ba0346ca8eaea1ef840cc405_D20210303-20210303" id="id3VybDovL2RvY3MudjEvZG9jOjk3MjU2YWVkYzUwNjQ3ODU4Mjc1YjA4MTYyMTUwZjU2L3NlYzo5NzI1NmFlZGM1MDY0Nzg1ODI3NWIwODE2MjE1MGY1Nl8xL2ZyYWc6MTI0M2Q5ZjEwNzEwNGJiMTk1YWRiZTEzODVlN2E5YTUvdGV4dHJlZ2lvbjoxMjQzZDlmMTA3MTA0YmIxOTVhZGJlMTM4NWU3YTlhNV8xNjA1_0c990ec9-c0b0-4d1f-a8f2-615468eb25ad"> false </dei:EntityEmergingGrowthCompany> |
| </xbrl> |