SEC Info  
    Home      Search      My Interests      Help      Sign In      Please Sign In

Nymox Pharmaceutical Corp. – ‘20-F’ for 12/31/20 – ‘EX-101.DEF’

On:  Monday, 3/29/21, at 4:42pm ET   ·   For:  12/31/20   ·   Accession #:  1640334-21-680   ·   File #:  1-12033

Previous ‘20-F’:  ‘20-F’ on 3/30/20 for 12/31/19   ·   Next:  ‘20-F/A’ on 6/11/21 for 12/31/20   ·   Latest:  ‘20-F’ on 5/2/23 for 12/31/22   ·   4 References:   

Find Words in Filings emoji
 
  in    Show  and   Hints

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 3/29/21  Nymox Pharmaceutical Corp.        20-F       12/31/20  103:4.4M                                   Pubco Reporting … Inc/FA

Annual or Annual-Transition Report by a Foreign Non-Canadian Issuer   —   Form 20-F   —   SEA’34
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 20-F        Annual or Annual-Transition Report by a Foreign     HTML    684K 
                Non-Canadian Issuer                                              
 4: EX-13.A     Annual or Quarterly Report to Security Holders      HTML     24K 
 5: EX-13.B     Annual or Quarterly Report to Security Holders      HTML     24K 
 2: EX-12.A     Statement re: the Computation of Ratios             HTML     28K 
 3: EX-12.B     Statement re: the Computation of Ratios             HTML     28K 
12: R1          Cover                                               HTML     59K 
13: R2          Consolidated Statements of Comprehensive Loss       HTML     72K 
14: R3          Consolidated Statements of Financial Position       HTML     83K 
15: R4          Consolidated Statements of Financial Position       HTML     26K 
                (Parenthetical)                                                  
16: R5          Consolidated Statements of Cash Flow                HTML     85K 
17: R6          Consolidated Statements of Changes in Equity        HTML     59K 
18: R7          Business Activities and Basis of Presentation       HTML     30K 
19: R8          Going Concern Considerations                        HTML     26K 
20: R9          Significant Estimates                               HTML     25K 
21: R10         Significant Accounting Policies                     HTML     63K 
22: R11         New Accounting Standards and Interpretations        HTML     28K 
23: R12         Property and Equipment                              HTML     63K 
24: R13         Intangible Assets                                   HTML     25K 
25: R14         Accounts Payable and Accrued Liabilities            HTML     32K 
26: R15         Operating Leases and Commitments                    HTML     42K 
27: R16         Share Capital                                       HTML     33K 
28: R17         Stock Options                                       HTML     47K 
29: R18         Share Based Compensation                            HTML     30K 
30: R19         Warrants                                            HTML     43K 
31: R20         Income Taxes                                        HTML     55K 
32: R21         Earnings Per Share                                  HTML     31K 
33: R22         Financial Instruments Fair Value Disclosures        HTML     25K 
34: R23         Finance Income and Finance Costs                    HTML     34K 
35: R24         Segment Disclosures                                 HTML     34K 
36: R25         Concentrations                                      HTML     29K 
37: R26         Related Party Transactions                          HTML     34K 
38: R27         Research and Development Expenses                   HTML     33K 
39: R28         Personnel Expenses                                  HTML     31K 
40: R29         Capital Disclosures and Financial Risk              HTML     25K 
41: R30         Foreign Exchange Risk                               HTML     25K 
42: R31         Credit Risk                                         HTML     25K 
43: R32         Interest Rate Risk                                  HTML     24K 
44: R33         Liquidity Risk                                      HTML     29K 
45: R34         Subsequent Events                                   HTML     25K 
46: R35         Significant Accounting Policies (Policies)          HTML     92K 
47: R36         Significant Accounting Policies (Tables)            HTML     25K 
48: R37         New Accounting Standards and Interpretations        HTML     27K 
                (Tables)                                                         
49: R38         Property and Equipment (Tables)                     HTML     62K 
50: R39         Accounts Payable and Accrued Liabilities (Tables)   HTML     30K 
51: R40         Operating Leases and Commitments (Tables)           HTML     39K 
52: R41         Share Capital (Tables)                              HTML     30K 
53: R42         Stock Options (Tables)                              HTML     45K 
54: R43         Share Based Compensation (Tables)                   HTML     28K 
55: R44         Warrants (Tables)                                   HTML     39K 
56: R45         Income Taxes (Tables)                               HTML     50K 
57: R46         Earnings Per Share (Tables)                         HTML     28K 
58: R47         Finance Income and Finance Costs (Tables)           HTML     32K 
59: R48         Segment Disclosures (Tables)                        HTML     32K 
60: R49         Concentrations (Tables)                             HTML     27K 
61: R50         Related Party Transactions (Tables)                 HTML     28K 
62: R51         Research and Development Expenses (Tables)          HTML     31K 
63: R52         Personnel Expenses (Tables)                         HTML     29K 
64: R53         Liquidity Risk (Tables)                             HTML     27K 
65: R54         Significant Accounting Policies (Details)           HTML     31K 
66: R55         Significant Accounting Policies (Details            HTML     30K 
                Narrative)                                                       
67: R56         Property and Equipment (Details)                    HTML     48K 
68: R57         Property and Equipment (Details Narrative)          HTML     26K 
69: R58         Intangible Assets (Details Narrative)               HTML     29K 
70: R59         Accounts Payable and Accrued Liabilities (Details)  HTML     32K 
71: R60         Operating Leases and Commitments (Details)          HTML     29K 
72: R61         Operating Leases and Commitments (Details 1)        HTML     33K 
73: R62         Operating Leases and Commitment (Details            HTML     37K 
                Narrative)                                                       
74: R63         Share Capital (Details)                             HTML     26K 
75: R64         Share Capital (Details Narrative)                   HTML     35K 
76: R65         Stock Options (Details)                             HTML     48K 
77: R66         Stock Options (Details 1)                           HTML     42K 
78: R67         Stock Options (Details Narrative)                   HTML     27K 
79: R68         Share Based Compensation (Details)                  HTML     32K 
80: R69         Share Based Compensation (Details Narrative)        HTML     36K 
81: R70         Warrants (Details)                                  HTML     36K 
82: R71         Warrants (Details Narrative)                        HTML     30K 
83: R72         Income Taxes (Details)                              HTML     37K 
84: R73         Income Taxes (Details 1)                            HTML     27K 
85: R74         Income Taxes (Details 2)                            HTML     79K 
86: R75         Income Taxes (Details Narrative)                    HTML     25K 
87: R76         Earnings Per Share (Details)                        HTML     28K 
88: R77         Finance Income and Finance Costs (Details)          HTML     37K 
89: R78         Segment Disclosures (Details)                       HTML     40K 
90: R79         Concentrations (Details)                            HTML     32K 
91: R80         Related Party Transactions (Details)                HTML     34K 
92: R81         Related Party Transactions (Details Narrative)      HTML     33K 
93: R82         Research and Development Expenses (Details)         HTML     37K 
94: R83         Personnel Expenses (Details)                        HTML     31K 
95: R84         Personnel Expenses (Details Narrative)              HTML     29K 
96: R85         Capital Disclosures and Financial Risk (Details     HTML     32K 
                Narrative)                                                       
97: R86         Foreign Exchange Risk (Details Narrative)           HTML     25K 
98: R87         Credit Risk (Details Narrative)                     HTML     29K 
99: R88         Interest Rate Risk (Details Narrative)              HTML     24K 
100: R89         Liquidity Risk (Details)                            HTML     33K  
102: XML         IDEA XML File -- Filing Summary                      XML    188K  
101: EXCEL       IDEA Workbook of Financial Reports                  XLSX    106K  
 6: EX-101.INS  XBRL Instance -- nymox-20201231                      XML   1.27M 
 9: EX-101.CAL  XBRL Calculations -- nymox-20201231_cal              XML    150K 
11: EX-101.DEF  XBRL Definitions -- nymox-20201231_def               XML    385K 
 8: EX-101.LAB  XBRL Labels -- nymox-20201231_lab                    XML    773K 
10: EX-101.PRE  XBRL Presentations -- nymox-20201231_pre             XML    662K 
 7: EX-101.SCH  XBRL Schema -- nymox-20201231                        XSD    264K 
103: ZIP         XBRL Zipped Folder -- 0001640334-21-000680-xbrl      Zip    122K  


‘EX-101.DEF’   —   XBRL Definitions — nymox-20201231_def


This Exhibit is an XBRL XML File.


                                                                                                                                                                                
<?xml version="1.0" standalone="yes" encoding="windows-1252"?>
<!-- XBRL Document Created with XBRLMaster -->
<!-- Version: 2.3.08 -->
<!-- Based on XBRL 2.1 -->
<!-- Date of creation: 03/28/2021 -->
<!-- Software architectural design and coding: Dipendra K. Singh -->
<!-- Copyright (c) 2021 I-NET Business Solutions, Inc. All Rights Reserved. -->
<link:linkbase xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
<link:roleRef roleURI="http://nymox.com/role/Cover" xlink:href="nymox-20201231.xsd#Cover" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/ConsolidatedStatementsOfComprehensiveLoss" xlink:href="nymox-20201231.xsd#ConsolidatedStatementsOfComprehensiveLoss" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/ConsolidatedStatementsOfFinancialPosition" xlink:href="nymox-20201231.xsd#ConsolidatedStatementsOfFinancialPosition" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/ConsolidatedStatementsOfFinancialPositionParenthetical" xlink:href="nymox-20201231.xsd#ConsolidatedStatementsOfFinancialPositionParenthetical" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/ConsolidatedStatementsOfCashFlow" xlink:href="nymox-20201231.xsd#ConsolidatedStatementsOfCashFlow" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/ConsolidatedStatementsOfChangesInEquity" xlink:href="nymox-20201231.xsd#ConsolidatedStatementsOfChangesInEquity" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/BusinessActivitiesAndBasisOfPresentation" xlink:href="nymox-20201231.xsd#BusinessActivitiesAndBasisOfPresentation" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/GoingConcernConsiderations" xlink:href="nymox-20201231.xsd#GoingConcernConsiderations" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/SignificantEstimates" xlink:href="nymox-20201231.xsd#SignificantEstimates" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/SignificantAccountingPolicies" xlink:href="nymox-20201231.xsd#SignificantAccountingPolicies" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/NewAccountingStandardsAndInterpretations" xlink:href="nymox-20201231.xsd#NewAccountingStandardsAndInterpretations" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/PropertyAndEquipment" xlink:href="nymox-20201231.xsd#PropertyAndEquipment" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/IntangibleAssets" xlink:href="nymox-20201231.xsd#IntangibleAssets" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/AccountsPayableAndAccruedLiabilities" xlink:href="nymox-20201231.xsd#AccountsPayableAndAccruedLiabilities" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/OperatingLeasesAndCommitments" xlink:href="nymox-20201231.xsd#OperatingLeasesAndCommitments" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/ShareCapital" xlink:href="nymox-20201231.xsd#ShareCapital" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/StockOptions" xlink:href="nymox-20201231.xsd#StockOptions" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/ShareBasedCompensation" xlink:href="nymox-20201231.xsd#ShareBasedCompensation" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/WARRANTS" xlink:href="nymox-20201231.xsd#WARRANTS" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/IncomeTaxes" xlink:href="nymox-20201231.xsd#IncomeTaxes" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/EarningsPerShare" xlink:href="nymox-20201231.xsd#EarningsPerShare" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/FinancialInstrumentsFairValueDisclosures" xlink:href="nymox-20201231.xsd#FinancialInstrumentsFairValueDisclosures" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/FinanceIncomeAndFinanceCosts" xlink:href="nymox-20201231.xsd#FinanceIncomeAndFinanceCosts" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/SegmentDisclosures" xlink:href="nymox-20201231.xsd#SegmentDisclosures" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/CONCENTRATIONS" xlink:href="nymox-20201231.xsd#CONCENTRATIONS" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/RelatedPartyTransactions" xlink:href="nymox-20201231.xsd#RelatedPartyTransactions" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/ResearchAndDevelopmentExpenses" xlink:href="nymox-20201231.xsd#ResearchAndDevelopmentExpenses" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/PersonnelExpenses" xlink:href="nymox-20201231.xsd#PersonnelExpenses" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/CapitalDisclosuresAndFinancialRisk" xlink:href="nymox-20201231.xsd#CapitalDisclosuresAndFinancialRisk" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/ForeignExchangeRisk" xlink:href="nymox-20201231.xsd#ForeignExchangeRisk" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/CreditRisk" xlink:href="nymox-20201231.xsd#CreditRisk" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/InterestRateRisk" xlink:href="nymox-20201231.xsd#InterestRateRisk" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/LiquidityRisk" xlink:href="nymox-20201231.xsd#LiquidityRisk" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/SubsequentEvents" xlink:href="nymox-20201231.xsd#SubsequentEvents" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/SignificantAccountingPoliciesPolicies" xlink:href="nymox-20201231.xsd#SignificantAccountingPoliciesPolicies" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/SignificantAccountingPoliciesTables" xlink:href="nymox-20201231.xsd#SignificantAccountingPoliciesTables" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/NewAccountingStandardsAndInterpretationsTables" xlink:href="nymox-20201231.xsd#NewAccountingStandardsAndInterpretationsTables" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/PropertyAndEquipmentTables" xlink:href="nymox-20201231.xsd#PropertyAndEquipmentTables" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/AccountsPayableAndAccruedLiabilitiesTables" xlink:href="nymox-20201231.xsd#AccountsPayableAndAccruedLiabilitiesTables" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/OperatingLeasesAndCommitmentsTables" xlink:href="nymox-20201231.xsd#OperatingLeasesAndCommitmentsTables" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/ShareCapitalTables" xlink:href="nymox-20201231.xsd#ShareCapitalTables" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/StockOptionsTables" xlink:href="nymox-20201231.xsd#StockOptionsTables" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/ShareBasedCompensationTables" xlink:href="nymox-20201231.xsd#ShareBasedCompensationTables" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/WarrantsTables" xlink:href="nymox-20201231.xsd#WarrantsTables" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/IncomeTaxesTables" xlink:href="nymox-20201231.xsd#IncomeTaxesTables" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/EarningsPerShareTables" xlink:href="nymox-20201231.xsd#EarningsPerShareTables" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/FinanceIncomeAndFinanceCostsTables" xlink:href="nymox-20201231.xsd#FinanceIncomeAndFinanceCostsTables" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/SegmentDisclosuresTables" xlink:href="nymox-20201231.xsd#SegmentDisclosuresTables" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/ConcentrationsTables" xlink:href="nymox-20201231.xsd#ConcentrationsTables" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/RelatedPartyTransactionsTables" xlink:href="nymox-20201231.xsd#RelatedPartyTransactionsTables" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/ResearchAndDevelopmentExpensesTables" xlink:href="nymox-20201231.xsd#ResearchAndDevelopmentExpensesTables" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/PersonnelExpensesTables" xlink:href="nymox-20201231.xsd#PersonnelExpensesTables" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/LiquidityRiskTables" xlink:href="nymox-20201231.xsd#LiquidityRiskTables" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/SignificantAccountingPoliciesDetails" xlink:href="nymox-20201231.xsd#SignificantAccountingPoliciesDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/SignificantAccountingPoliciesDetailsNarrative" xlink:href="nymox-20201231.xsd#SignificantAccountingPoliciesDetailsNarrative" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/PropertyAndEquipmentDetails" xlink:href="nymox-20201231.xsd#PropertyAndEquipmentDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/PropertyAndEquipmentDetailsNarrative" xlink:href="nymox-20201231.xsd#PropertyAndEquipmentDetailsNarrative" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/IntangibleAssetsDetailsNarrative" xlink:href="nymox-20201231.xsd#IntangibleAssetsDetailsNarrative" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/AccountsPayableAndAccruedLiabilitiesDetails" xlink:href="nymox-20201231.xsd#AccountsPayableAndAccruedLiabilitiesDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/OperatingLeasesAndCommitmentsDetails" xlink:href="nymox-20201231.xsd#OperatingLeasesAndCommitmentsDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/OperatingLeasesAndCommitmentsDetails1" xlink:href="nymox-20201231.xsd#OperatingLeasesAndCommitmentsDetails1" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/OperatingLeasesAndCommitmentDetailsNarrative" xlink:href="nymox-20201231.xsd#OperatingLeasesAndCommitmentDetailsNarrative" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/ShareCapitalDetails" xlink:href="nymox-20201231.xsd#ShareCapitalDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/ShareCapitalDetailsNarrative" xlink:href="nymox-20201231.xsd#ShareCapitalDetailsNarrative" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/StockOptionsDetails" xlink:href="nymox-20201231.xsd#StockOptionsDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/StockOptionsDetails1" xlink:href="nymox-20201231.xsd#StockOptionsDetails1" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/StockOptionsDetailsNarrative" xlink:href="nymox-20201231.xsd#StockOptionsDetailsNarrative" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/ShareBasedCompensationDetails" xlink:href="nymox-20201231.xsd#ShareBasedCompensationDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/ShareBasedCompensationDetailsNarrative" xlink:href="nymox-20201231.xsd#ShareBasedCompensationDetailsNarrative" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/WarrantsDetails" xlink:href="nymox-20201231.xsd#WarrantsDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/WarrantsDetailsNarrative" xlink:href="nymox-20201231.xsd#WarrantsDetailsNarrative" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/IncomeTaxesDetails" xlink:href="nymox-20201231.xsd#IncomeTaxesDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/IncomeTaxesDetails1" xlink:href="nymox-20201231.xsd#IncomeTaxesDetails1" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/IncomeTaxesDetails2" xlink:href="nymox-20201231.xsd#IncomeTaxesDetails2" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/IncomeTaxesDetailsNarrative" xlink:href="nymox-20201231.xsd#IncomeTaxesDetailsNarrative" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/EarningsPerShareDetails" xlink:href="nymox-20201231.xsd#EarningsPerShareDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/FinanceIncomeAndFinanceCostsDetails" xlink:href="nymox-20201231.xsd#FinanceIncomeAndFinanceCostsDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/SegmentDisclosuresDetails" xlink:href="nymox-20201231.xsd#SegmentDisclosuresDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/ConcentrationsDetails" xlink:href="nymox-20201231.xsd#ConcentrationsDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/RelatedPartyTransactionsDetails" xlink:href="nymox-20201231.xsd#RelatedPartyTransactionsDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/RelatedPartyTransactionsDetailsNarrative" xlink:href="nymox-20201231.xsd#RelatedPartyTransactionsDetailsNarrative" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/ResearchAndDevelopmentExpensesDetails" xlink:href="nymox-20201231.xsd#ResearchAndDevelopmentExpensesDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/PersonnelExpensesDetails" xlink:href="nymox-20201231.xsd#PersonnelExpensesDetails" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/PersonnelExpensesDetailsNarrative" xlink:href="nymox-20201231.xsd#PersonnelExpensesDetailsNarrative" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/CapitalDisclosuresAndFinancialRiskDetailsNarrative" xlink:href="nymox-20201231.xsd#CapitalDisclosuresAndFinancialRiskDetailsNarrative" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/ForeignExchangeRiskDetailsNarrative" xlink:href="nymox-20201231.xsd#ForeignExchangeRiskDetailsNarrative" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/CreditRiskDetailsNarrative" xlink:href="nymox-20201231.xsd#CreditRiskDetailsNarrative" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/InterestRateRiskDetailsNarrative" xlink:href="nymox-20201231.xsd#InterestRateRiskDetailsNarrative" xlink:type="simple"/>
<link:roleRef roleURI="http://nymox.com/role/LiquidityRiskDetails" xlink:href="nymox-20201231.xsd#LiquidityRiskDetails" xlink:type="simple"/>
<link:arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension" arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension"/>
<link:arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain" arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain"/>
<link:arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member" arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member"/>
<link:arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all" arcroleURI="http://xbrl.org/int/dim/arcrole/all"/>
<link:arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#notAll" arcroleURI="http://xbrl.org/int/dim/arcrole/notAll"/>
<link:arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default" arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/Cover" xlink:title="00000001 - Document - Cover Page Information">
<link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CoverAbstract" xlink:label="loc_deiCover"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/ConsolidatedStatementsOfComprehensiveLoss" xlink:title="000002 - Statement - Consolidated Statements of Comprehensive Loss"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/ConsolidatedStatementsOfFinancialPosition" xlink:title="000003 - Statement - Consolidated Statements of Financial Position"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/ConsolidatedStatementsOfFinancialPositionParenthetical" xlink:title="000004 - Statement - Consolidated Statements of Financial Position (Parenthetical)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/ConsolidatedStatementsOfCashFlow" xlink:title="000005 - Statement - Consolidated Statements of Cash Flow"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/ConsolidatedStatementsOfChangesInEquity" xlink:title="000006 - Statement - Consolidated Statements of Changes in Equity">
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementLineItems" xlink:label="loc_nymoxStatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementTable" xlink:label="loc_nymoxStatementTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStatementTable" order="2000" xbrldt:contextElement="segment" xbrldt:closed="true"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_ComponentsOfEquityAxis" xlink:label="loc_ifrs-fullComponentsOfEquityAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_nymoxStatementTable" xlink:to="loc_ifrs-fullComponentsOfEquityAxis" order="20"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_EquityMember" xlink:label="loc_ifrs-fullEquityMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-fullComponentsOfEquityAxis" xlink:to="loc_ifrs-fullEquityMember" order="30"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_EquityMember" xlink:label="loc_ifrs-fullEquityMember_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ifrs-fullComponentsOfEquityAxis" xlink:to="loc_ifrs-fullEquityMember_10" order="40" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_IssuedCapitalMember" xlink:label="loc_ifrs-fullIssuedCapitalMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullEquityMember" xlink:to="loc_ifrs-fullIssuedCapitalMember" order="21"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_SharePremiumMember" xlink:label="loc_ifrs-fullSharePremiumMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullEquityMember" xlink:to="loc_ifrs-fullSharePremiumMember" order="22"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_OtherReservesMember" xlink:label="loc_ifrs-fullOtherReservesMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullEquityMember" xlink:to="loc_ifrs-fullOtherReservesMember" order="23"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_RetainedEarningsMember" xlink:label="loc_ifrs-fullRetainedEarningsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullEquityMember" xlink:to="loc_ifrs-fullRetainedEarningsMember" order="24"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_NumberOfSharesIssued" xlink:label="loc_ifrs-fullNumberOfSharesIssued"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullNumberOfSharesIssued" order="1"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_Equity" xlink:label="loc_ifrs-fullEquity"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullEquity" order="2"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_SharesIssuanceForCashAndSubscriptionsShares" xlink:label="loc_nymoxSharesIssuanceForCashAndSubscriptionsShares"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxSharesIssuanceForCashAndSubscriptionsShares" order="3"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_SharesIssuanceForCashAndSubscriptionsAmount" xlink:label="loc_nymoxSharesIssuanceForCashAndSubscriptionsAmount"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxSharesIssuanceForCashAndSubscriptionsAmount" order="4"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StockbasedCommissionShares" xlink:label="loc_nymoxStockbasedCommissionShares"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStockbasedCommissionShares" order="5"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StockbasedCommissionAmount" xlink:label="loc_nymoxStockbasedCommissionAmount"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStockbasedCommissionAmount" order="6"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StockbasedCompensationShares" xlink:label="loc_nymoxStockbasedCompensationShares"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStockbasedCompensationShares" order="7"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StockbasedCompensationAmount" xlink:label="loc_nymoxStockbasedCompensationAmount"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStockbasedCompensationAmount" order="8"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_ProfitLoss" xlink:label="loc_ifrs-fullProfitLoss"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullProfitLoss" order="9"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_LeaseAdoptionPriorYearCumulativeEffect" xlink:label="loc_nymoxLeaseAdoptionPriorYearCumulativeEffect"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxLeaseAdoptionPriorYearCumulativeEffect" order="10"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_WarrantIssued" xlink:label="loc_nymoxWarrantIssued"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxWarrantIssued" order="11"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StockbasedCompensationAndServiceFeeShares" xlink:label="loc_nymoxStockbasedCompensationAndServiceFeeShares"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStockbasedCompensationAndServiceFeeShares" order="12"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StockbasedCompensationAndServiceFeeAmount" xlink:label="loc_nymoxStockbasedCompensationAndServiceFeeAmount"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStockbasedCompensationAndServiceFeeAmount" order="13"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/BusinessActivitiesAndBasisOfPresentation" xlink:title="000007 - Disclosure - BUSINESS ACTIVITIES AND BASIS OF PRESENTATION"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/GoingConcernConsiderations" xlink:title="000008 - Disclosure - GOING CONCERN CONSIDERATIONS"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/SignificantEstimates" xlink:title="000009 - Disclosure - SIGNIFICANT ESTIMATES"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/SignificantAccountingPolicies" xlink:title="000010 - Disclosure - SIGNIFICANT ACCOUNTING POLICIES"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/NewAccountingStandardsAndInterpretations" xlink:title="000011 - Disclosure - NEW ACCOUNTING STANDARDS AND INTERPRETATIONS"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/PropertyAndEquipment" xlink:title="000012 - Disclosure - PROPERTY AND EQUIPMENT"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/IntangibleAssets" xlink:title="000013 - Disclosure - INTANGIBLE ASSETS"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/AccountsPayableAndAccruedLiabilities" xlink:title="000014 - Disclosure - ACCOUNTS PAYABLE AND ACCRUED LIABILITIES"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/OperatingLeasesAndCommitments" xlink:title="000015 - Disclosure - OPERATING LEASES AND COMMITMENTS"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/ShareCapital" xlink:title="000016 - Disclosure - SHARE CAPITAL"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/StockOptions" xlink:title="000017 - Disclosure - STOCK OPTIONS"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/ShareBasedCompensation" xlink:title="000018 - Disclosure - SHARE BASED COMPENSATION"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/WARRANTS" xlink:title="000019 - Disclosure - WARRANTS"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/IncomeTaxes" xlink:title="000020 - Disclosure - INCOME TAXES"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/EarningsPerShare" xlink:title="000021 - Disclosure - EARNINGS PER SHARE"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/FinancialInstrumentsFairValueDisclosures" xlink:title="000022 - Disclosure - FINANCIAL INSTRUMENTS FAIR VALUE DISCLOSURES"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/FinanceIncomeAndFinanceCosts" xlink:title="000023 - Disclosure - FINANCE INCOME AND FINANCE COSTS"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/SegmentDisclosures" xlink:title="000024 - Disclosure - SEGMENT DISCLOSURES"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/CONCENTRATIONS" xlink:title="000025 - Disclosure - CONCENTRATIONS"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/RelatedPartyTransactions" xlink:title="000026 - Disclosure - RELATED PARTY TRANSACTIONS"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/ResearchAndDevelopmentExpenses" xlink:title="000027 - Disclosure - RESEARCH AND DEVELOPMENT EXPENSES"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/PersonnelExpenses" xlink:title="000028 - Disclosure - PERSONNEL EXPENSES"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/CapitalDisclosuresAndFinancialRisk" xlink:title="000029 - Disclosure - CAPITAL DISCLOSURES AND FINANCIAL RISK"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/ForeignExchangeRisk" xlink:title="000030 - Disclosure - FOREIGN EXCHANGE RISK"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/CreditRisk" xlink:title="000031 - Disclosure - CREDIT RISK"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/InterestRateRisk" xlink:title="000032 - Disclosure - INTEREST RATE RISK"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/LiquidityRisk" xlink:title="000033 - Disclosure - LIQUIDITY RISK"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/SubsequentEvents" xlink:title="000034 - Disclosure - SUBSEQUENT EVENTS"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/SignificantAccountingPoliciesPolicies" xlink:title="000035 - Disclosure - SIGNIFICANT ACCOUNTING POLICIES (Policies)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/SignificantAccountingPoliciesTables" xlink:title="000036 - Disclosure - SIGNIFICANT ACCOUNTING POLICIES (Tables)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/NewAccountingStandardsAndInterpretationsTables" xlink:title="000037 - Disclosure - NEW ACCOUNTING STANDARDS AND INTERPRETATIONS (Tables)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/PropertyAndEquipmentTables" xlink:title="000038 - Disclosure - PROPERTY AND EQUIPMENT (Tables)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/AccountsPayableAndAccruedLiabilitiesTables" xlink:title="000039 - Disclosure - ACCOUNTS PAYABLE AND ACCRUED LIABILITIES (Tables)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/OperatingLeasesAndCommitmentsTables" xlink:title="000040 - Disclosure - OPERATING LEASES AND COMMITMENTS (Tables)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/ShareCapitalTables" xlink:title="000041 - Disclosure - SHARE CAPITAL (Tables)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/StockOptionsTables" xlink:title="000042 - Disclosure - STOCK OPTIONS (Tables)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/ShareBasedCompensationTables" xlink:title="000043 - Disclosure - SHARE BASED COMPENSATION (Tables)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/WarrantsTables" xlink:title="000044 - Disclosure - WARRANTS (Tables)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/IncomeTaxesTables" xlink:title="000045 - Disclosure - INCOME TAXES (Tables)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/EarningsPerShareTables" xlink:title="000046 - Disclosure - EARNINGS PER SHARE (Tables)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/FinanceIncomeAndFinanceCostsTables" xlink:title="000047 - Disclosure - FINANCE INCOME AND FINANCE COSTS (Tables)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/SegmentDisclosuresTables" xlink:title="000048 - Disclosure - SEGMENT DISCLOSURES (Tables)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/ConcentrationsTables" xlink:title="000049 - Disclosure - CONCENTRATIONS (Tables)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/RelatedPartyTransactionsTables" xlink:title="000050 - Disclosure - RELATED PARTY TRANSACTIONS (Tables)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/ResearchAndDevelopmentExpensesTables" xlink:title="000051 - Disclosure - RESEARCH AND DEVELOPMENT EXPENSES (Tables)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/PersonnelExpensesTables" xlink:title="000052 - Disclosure - PERSONNEL EXPENSES (Tables)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/LiquidityRiskTables" xlink:title="000053 - Disclosure - LIQUIDITY RISK (Tables)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/SignificantAccountingPoliciesDetails" xlink:title="000054 - Disclosure - SIGNIFICANT ACCOUNTING POLICIES (Details)">
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementLineItems" xlink:label="loc_nymoxStatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementTable" xlink:label="loc_nymoxStatementTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStatementTable" order="2000" xbrldt:contextElement="segment" xbrldt:closed="true"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_ClassesOfAssetsAxis" xlink:label="loc_ifrs-fullClassesOfAssetsAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_nymoxStatementTable" xlink:to="loc_ifrs-fullClassesOfAssetsAxis" order="20"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_ClassesOfAssetsMember" xlink:label="loc_ifrs-fullClassesOfAssetsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-fullClassesOfAssetsAxis" xlink:to="loc_ifrs-fullClassesOfAssetsMember" order="30"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_ClassesOfAssetsMember" xlink:label="loc_ifrs-fullClassesOfAssetsMember_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ifrs-fullClassesOfAssetsAxis" xlink:to="loc_ifrs-fullClassesOfAssetsMember_10" order="40" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_LaboratoryEquipmentMember" xlink:label="loc_nymoxLaboratoryEquipmentMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullClassesOfAssetsMember" xlink:to="loc_nymoxLaboratoryEquipmentMember" order="21"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_ComputerEquipmentMember" xlink:label="loc_ifrs-fullComputerEquipmentMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullClassesOfAssetsMember" xlink:to="loc_ifrs-fullComputerEquipmentMember" order="22"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_OfficeEquipmentAndFixturesMember" xlink:label="loc_nymoxOfficeEquipmentAndFixturesMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullClassesOfAssetsMember" xlink:to="loc_nymoxOfficeEquipmentAndFixturesMember" order="23"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_PropertyAndEquipmentEstimatedUsefulLives" xlink:label="loc_nymoxPropertyAndEquipmentEstimatedUsefulLives"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxPropertyAndEquipmentEstimatedUsefulLives" order="1"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/SignificantAccountingPoliciesDetailsNarrative" xlink:title="000055 - Disclosure - SIGNIFICANT ACCOUNTING POLICIES (Details Narrative)">
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementLineItems" xlink:label="loc_nymoxStatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementTable" xlink:label="loc_nymoxStatementTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStatementTable" order="2000" xbrldt:contextElement="segment" xbrldt:closed="true"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_CreationDateAxis" xlink:label="loc_ifrs-fullCreationDateAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_nymoxStatementTable" xlink:to="loc_ifrs-fullCreationDateAxis" order="20"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_DefaultFinancialStatementsDateMember" xlink:label="loc_ifrs-fullDefaultFinancialStatementsDateMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-fullCreationDateAxis" xlink:to="loc_ifrs-fullDefaultFinancialStatementsDateMember" order="30"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_DefaultFinancialStatementsDateMember" xlink:label="loc_ifrs-fullDefaultFinancialStatementsDateMember_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ifrs-fullCreationDateAxis" xlink:to="loc_ifrs-fullDefaultFinancialStatementsDateMember_10" order="40" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_JanuaryOneTwoZeroOneNineMember" xlink:label="loc_nymoxJanuaryOneTwoZeroOneNineMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullDefaultFinancialStatementsDateMember" xlink:to="loc_nymoxJanuaryOneTwoZeroOneNineMember" order="21"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_TradeAndOtherCurrentReceivables" xlink:label="loc_ifrs-fullTradeAndOtherCurrentReceivables"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullTradeAndOtherCurrentReceivables" order="1"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_ImmaterialCumulativeAdjustment" xlink:label="loc_nymoxImmaterialCumulativeAdjustment"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxImmaterialCumulativeAdjustment" order="2"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/PropertyAndEquipmentDetails" xlink:title="000056 - Disclosure - PROPERTY AND EQUIPMENT (Details)">
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementLineItems" xlink:label="loc_nymoxStatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementTable" xlink:label="loc_nymoxStatementTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStatementTable" order="2000" xbrldt:contextElement="segment" xbrldt:closed="true"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_ClassesOfAssetsAxis" xlink:label="loc_ifrs-fullClassesOfAssetsAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_nymoxStatementTable" xlink:to="loc_ifrs-fullClassesOfAssetsAxis" order="10"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_ClassesOfAssetsMember" xlink:label="loc_ifrs-fullClassesOfAssetsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-fullClassesOfAssetsAxis" xlink:to="loc_ifrs-fullClassesOfAssetsMember" order="20"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_ClassesOfAssetsMember" xlink:label="loc_ifrs-fullClassesOfAssetsMember_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ifrs-fullClassesOfAssetsAxis" xlink:to="loc_ifrs-fullClassesOfAssetsMember_10" order="30" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_LaboratoryEquipmentMember" xlink:label="loc_nymoxLaboratoryEquipmentMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullClassesOfAssetsMember" xlink:to="loc_nymoxLaboratoryEquipmentMember" order="11"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_ComputerEquipmentMember" xlink:label="loc_ifrs-fullComputerEquipmentMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullClassesOfAssetsMember" xlink:to="loc_ifrs-fullComputerEquipmentMember" order="12"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_OfficeEquipmentMember" xlink:label="loc_ifrs-fullOfficeEquipmentMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullClassesOfAssetsMember" xlink:to="loc_ifrs-fullOfficeEquipmentMember" order="13"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_PropertyPlantAndEquipmentCarryingAmountAtCostOfRevaluedAssets" xlink:label="loc_ifrs-fullPropertyPlantAndEquipmentCarryingAmountAtCostOfRevaluedAssets"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullPropertyPlantAndEquipmentCarryingAmountAtCostOfRevaluedAssets" order="1"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_AdditionsOtherThanThroughBusinessCombinationsPropertyPlantAndEquipment" xlink:label="loc_ifrs-fullAdditionsOtherThanThroughBusinessCombinationsPropertyPlantAndEquipment"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullAdditionsOtherThanThroughBusinessCombinationsPropertyPlantAndEquipment" order="2"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_AccumulatedDepreciationAndAmortizationAssets" xlink:label="loc_nymoxAccumulatedDepreciationAndAmortizationAssets"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxAccumulatedDepreciationAndAmortizationAssets" order="4"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_DepreciationExpense" xlink:label="loc_ifrs-fullDepreciationExpense"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullDepreciationExpense" order="5"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_CarryingValueOfPropertyAndEquipment" xlink:label="loc_nymoxCarryingValueOfPropertyAndEquipment"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxCarryingValueOfPropertyAndEquipment" order="7"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/PropertyAndEquipmentDetailsNarrative" xlink:title="000057 - Disclosure - PROPERTY AND EQUIPMENT (Details Narrative)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/IntangibleAssetsDetailsNarrative" xlink:title="000058 - Disclosure - INTANGIBLE ASSETS (Details Narrative)">
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementLineItems" xlink:label="loc_nymoxStatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementTable" xlink:label="loc_nymoxStatementTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStatementTable" order="2000" xbrldt:contextElement="segment" xbrldt:closed="true"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_ClassesOfIntangibleAssetsAndGoodwillAxis" xlink:label="loc_ifrs-fullClassesOfIntangibleAssetsAndGoodwillAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_nymoxStatementTable" xlink:to="loc_ifrs-fullClassesOfIntangibleAssetsAndGoodwillAxis" order="20"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_IntangibleAssetsAndGoodwillMember" xlink:label="loc_ifrs-fullIntangibleAssetsAndGoodwillMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-fullClassesOfIntangibleAssetsAndGoodwillAxis" xlink:to="loc_ifrs-fullIntangibleAssetsAndGoodwillMember" order="30"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_IntangibleAssetsAndGoodwillMember" xlink:label="loc_ifrs-fullIntangibleAssetsAndGoodwillMember_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ifrs-fullClassesOfIntangibleAssetsAndGoodwillAxis" xlink:to="loc_ifrs-fullIntangibleAssetsAndGoodwillMember_10" order="40" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_IntellectualPropertyRightsMember" xlink:label="loc_nymoxIntellectualPropertyRightsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullIntangibleAssetsAndGoodwillMember" xlink:to="loc_nymoxIntellectualPropertyRightsMember" order="21"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_IntangibleAssetsAndGoodwill" xlink:label="loc_ifrs-fullIntangibleAssetsAndGoodwill"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullIntangibleAssetsAndGoodwill" order="1"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_AmortisationExpense" xlink:label="loc_ifrs-fullAmortisationExpense"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullAmortisationExpense" order="2"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/AccountsPayableAndAccruedLiabilitiesDetails" xlink:title="000059 - Disclosure - ACCOUNTS PAYABLE AND ACCRUED LIABILITIES (Details)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/OperatingLeasesAndCommitmentsDetails" xlink:title="000060 - Disclosure - OPERATING LEASES AND COMMITMENTS (Details)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/OperatingLeasesAndCommitmentsDetails1" xlink:title="000061 - Disclosure - OPERATING LEASES AND COMMITMENTS (Details 1)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/OperatingLeasesAndCommitmentDetailsNarrative" xlink:title="000062 - Disclosure - OPERATING LEASES AND COMMITMENT (Details Narrative)">
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementLineItems" xlink:label="loc_nymoxStatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementTable" xlink:label="loc_nymoxStatementTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStatementTable" order="2000" xbrldt:contextElement="segment" xbrldt:closed="true"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_CreationDateAxis" xlink:label="loc_ifrs-fullCreationDateAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_nymoxStatementTable" xlink:to="loc_ifrs-fullCreationDateAxis" order="10"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_DefaultFinancialStatementsDateMember" xlink:label="loc_ifrs-fullDefaultFinancialStatementsDateMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-fullCreationDateAxis" xlink:to="loc_ifrs-fullDefaultFinancialStatementsDateMember" order="20"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_DefaultFinancialStatementsDateMember" xlink:label="loc_ifrs-fullDefaultFinancialStatementsDateMember_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ifrs-fullCreationDateAxis" xlink:to="loc_ifrs-fullDefaultFinancialStatementsDateMember_10" order="30" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_JanuaryOneTwoZeroOneNineMember" xlink:label="loc_nymoxJanuaryOneTwoZeroOneNineMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullDefaultFinancialStatementsDateMember" xlink:to="loc_nymoxJanuaryOneTwoZeroOneNineMember" order="11"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_OctoberTwoZeroTwoZeroMember" xlink:label="loc_nymoxOctoberTwoZeroTwoZeroMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullDefaultFinancialStatementsDateMember" xlink:to="loc_nymoxOctoberTwoZeroTwoZeroMember" order="12"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_LeaseLiabilities" xlink:label="loc_ifrs-fullLeaseLiabilities"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullLeaseLiabilities" order="1"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_FuturePaymentAmount" xlink:label="loc_nymoxFuturePaymentAmount"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxFuturePaymentAmount" order="2"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_AverageRemainingYears" xlink:label="loc_nymoxAverageRemainingYears"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxAverageRemainingYears" order="3"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_LeaseExpirydate" xlink:label="loc_nymoxLeaseExpirydate"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxLeaseExpirydate" order="4"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_ImmaterialCumulativeAdjustment" xlink:label="loc_nymoxImmaterialCumulativeAdjustment"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxImmaterialCumulativeAdjustment" order="5"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_DiscountRateDescription" xlink:label="loc_nymoxDiscountRateDescription"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxDiscountRateDescription" order="6"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/ShareCapitalDetails" xlink:title="000063 - Disclosure - SHARE CAPITAL (Details)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/ShareCapitalDetailsNarrative" xlink:title="000064 - Disclosure - SHARE CAPITAL (Details Narrative)">
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementLineItems" xlink:label="loc_nymoxStatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementTable" xlink:label="loc_nymoxStatementTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStatementTable" order="2000" xbrldt:contextElement="segment" xbrldt:closed="true"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:label="loc_ifrs-fullCategoriesOfRelatedPartiesAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_nymoxStatementTable" xlink:to="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" order="20"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_EntitysTotalForRelatedPartiesMember" xlink:label="loc_ifrs-fullEntitysTotalForRelatedPartiesMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" xlink:to="loc_ifrs-fullEntitysTotalForRelatedPartiesMember" order="30"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_EntitysTotalForRelatedPartiesMember" xlink:label="loc_ifrs-fullEntitysTotalForRelatedPartiesMember_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" xlink:to="loc_ifrs-fullEntitysTotalForRelatedPartiesMember_10" order="40" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_ChardanCapitalMarketsLLCMember" xlink:label="loc_nymoxChardanCapitalMarketsLLCMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullEntitysTotalForRelatedPartiesMember" xlink:to="loc_nymoxChardanCapitalMarketsLLCMember" order="21"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_ThreePrivatePlacementsMember" xlink:label="loc_nymoxThreePrivatePlacementsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullEntitysTotalForRelatedPartiesMember" xlink:to="loc_nymoxThreePrivatePlacementsMember" order="22"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_ProspectusSupplementAndAccompanyingProspectusDescription" xlink:label="loc_nymoxProspectusSupplementAndAccompanyingProspectusDescription"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxProspectusSupplementAndAccompanyingProspectusDescription" order="1"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_ProceedsFromIssuanceOfCommonStocks" xlink:label="loc_nymoxProceedsFromIssuanceOfCommonStocks"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxProceedsFromIssuanceOfCommonStocks" order="2"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_FeesCharges" xlink:label="loc_nymoxFeesCharges"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxFeesCharges" order="3"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_CommonStockShareIssued" xlink:label="loc_nymoxCommonStockShareIssued"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxCommonStockShareIssued" order="4"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_PricePerShare" xlink:label="loc_nymoxPricePerShare"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxPricePerShare" order="5"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/StockOptionsDetails" xlink:title="000065 - Disclosure - STOCK OPTIONS (Details)">
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementLineItems" xlink:label="loc_nymoxStatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementTable" xlink:label="loc_nymoxStatementTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStatementTable" order="2000" xbrldt:contextElement="segment" xbrldt:closed="true"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_ClassesOfFinancialAssetsAxis" xlink:label="loc_ifrs-fullClassesOfFinancialAssetsAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_nymoxStatementTable" xlink:to="loc_ifrs-fullClassesOfFinancialAssetsAxis" order="20"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_FinancialAssetsMember" xlink:label="loc_ifrs-fullFinancialAssetsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-fullClassesOfFinancialAssetsAxis" xlink:to="loc_ifrs-fullFinancialAssetsMember" order="30"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_FinancialAssetsMember" xlink:label="loc_ifrs-fullFinancialAssetsMember_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ifrs-fullClassesOfFinancialAssetsAxis" xlink:to="loc_ifrs-fullFinancialAssetsMember_10" order="40" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StockOptionsMember" xlink:label="loc_nymoxStockOptionsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullFinancialAssetsMember" xlink:to="loc_nymoxStockOptionsMember" order="21"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_NumberOfOutstandingBalanceBeginning" xlink:label="loc_nymoxNumberOfOutstandingBalanceBeginning"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxNumberOfOutstandingBalanceBeginning" order="1"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_NumberOfShareOptionsExpiredUnderlyingShares" xlink:label="loc_nymoxNumberOfShareOptionsExpiredUnderlyingShares"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxNumberOfShareOptionsExpiredUnderlyingShares" order="2"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_NumberOfShareOptionsGrantedUnderlyingShares" xlink:label="loc_nymoxNumberOfShareOptionsGrantedUnderlyingShares"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxNumberOfShareOptionsGrantedUnderlyingShares" order="3"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_NumberOfOutstandingBalanceEnding" xlink:label="loc_nymoxNumberOfOutstandingBalanceEnding"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxNumberOfOutstandingBalanceEnding" order="4"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_NumberOfShareOptionsOutstandingExercisableUnderlyingShares" xlink:label="loc_nymoxNumberOfShareOptionsOutstandingExercisableUnderlyingShares"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxNumberOfShareOptionsOutstandingExercisableUnderlyingShares" order="5"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_WeightedAverageExercisePriceBeginning" xlink:label="loc_nymoxWeightedAverageExercisePriceBeginning"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxWeightedAverageExercisePriceBeginning" order="6"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_WeightedAverageExercisePriceExpired" xlink:label="loc_nymoxWeightedAverageExercisePriceExpired"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxWeightedAverageExercisePriceExpired" order="7"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_WeightedAverageExercisePriceGranted" xlink:label="loc_nymoxWeightedAverageExercisePriceGranted"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxWeightedAverageExercisePriceGranted" order="8"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_WeightedAverageExercisePriceEnding" xlink:label="loc_nymoxWeightedAverageExercisePriceEnding"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxWeightedAverageExercisePriceEnding" order="9"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_WeightedAverageExercisePriceOptionsExercisable" xlink:label="loc_nymoxWeightedAverageExercisePriceOptionsExercisable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxWeightedAverageExercisePriceOptionsExercisable" order="10"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_WeightedAverageRemainingContractualLifeInYearsBeginning" xlink:label="loc_nymoxWeightedAverageRemainingContractualLifeInYearsBeginning"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxWeightedAverageRemainingContractualLifeInYearsBeginning" order="11"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_WeightedAverageRemainingContractualLifeInYearsGranted" xlink:label="loc_nymoxWeightedAverageRemainingContractualLifeInYearsGranted"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxWeightedAverageRemainingContractualLifeInYearsGranted" order="12"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_WeightedAverageRemainingContractualLifeOptionsOutstanding" xlink:label="loc_nymoxWeightedAverageRemainingContractualLifeOptionsOutstanding"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxWeightedAverageRemainingContractualLifeOptionsOutstanding" order="13"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_WeightedAverageRemainingContractualLifeInExercisable" xlink:label="loc_nymoxWeightedAverageRemainingContractualLifeInExercisable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxWeightedAverageRemainingContractualLifeInExercisable" order="14"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/StockOptionsDetails1" xlink:title="000066 - Disclosure - STOCK OPTIONS (Details 1)">
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementLineItems" xlink:label="loc_nymoxStatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementTable" xlink:label="loc_nymoxStatementTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStatementTable" order="2000" xbrldt:contextElement="segment" xbrldt:closed="true"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_RangeAxis" xlink:label="loc_ifrs-fullRangeAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_nymoxStatementTable" xlink:to="loc_ifrs-fullRangeAxis" order="20"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_RangesMember" xlink:label="loc_ifrs-fullRangesMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-fullRangeAxis" xlink:to="loc_ifrs-fullRangesMember" order="30"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_RangesMember" xlink:label="loc_ifrs-fullRangesMember_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ifrs-fullRangeAxis" xlink:to="loc_ifrs-fullRangesMember_10" order="40" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_MinimumMember" xlink:label="loc_nymoxMinimumMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullRangesMember" xlink:to="loc_nymoxMinimumMember" order="21"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_MaximumMember" xlink:label="loc_nymoxMaximumMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullRangesMember" xlink:to="loc_nymoxMaximumMember" order="22"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_OptionSharePrice" xlink:label="loc_nymoxOptionSharePrice"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxOptionSharePrice" order="1"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_OptionExercisePrice" xlink:label="loc_nymoxOptionExercisePrice"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxOptionExercisePrice" order="2"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_DescriptionOfRiskFreeInterestRateShareOptionsGranted" xlink:label="loc_ifrs-fullDescriptionOfRiskFreeInterestRateShareOptionsGranted"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullDescriptionOfRiskFreeInterestRateShareOptionsGranted" order="3"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_DescriptionOfExpectedVolatilityShareOptionsGranted" xlink:label="loc_ifrs-fullDescriptionOfExpectedVolatilityShareOptionsGranted"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullDescriptionOfExpectedVolatilityShareOptionsGranted" order="4"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_ExpectedOptionLifeInYears" xlink:label="loc_nymoxExpectedOptionLifeInYears"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxExpectedOptionLifeInYears" order="5"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_ExpectedDividendYieldShareOptionsGranted" xlink:label="loc_nymoxExpectedDividendYieldShareOptionsGranted"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxExpectedDividendYieldShareOptionsGranted" order="6"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/StockOptionsDetailsNarrative" xlink:title="000067 - Disclosure - STOCK OPTIONS (Details Narrative)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/ShareBasedCompensationDetails" xlink:title="000068 - Disclosure - SHARE BASED COMPENSATION (Details)">
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementLineItems" xlink:label="loc_nymoxStatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementTable" xlink:label="loc_nymoxStatementTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStatementTable" order="2000" xbrldt:contextElement="segment" xbrldt:closed="true"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_ClassesOfFinancialAssetsAxis" xlink:label="loc_ifrs-fullClassesOfFinancialAssetsAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_nymoxStatementTable" xlink:to="loc_ifrs-fullClassesOfFinancialAssetsAxis" order="10"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_FinancialAssetsMember" xlink:label="loc_ifrs-fullFinancialAssetsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-fullClassesOfFinancialAssetsAxis" xlink:to="loc_ifrs-fullFinancialAssetsMember" order="20"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_FinancialAssetsMember" xlink:label="loc_ifrs-fullFinancialAssetsMember_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ifrs-fullClassesOfFinancialAssetsAxis" xlink:to="loc_ifrs-fullFinancialAssetsMember_10" order="30" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StockOptionsMember" xlink:label="loc_nymoxStockOptionsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullFinancialAssetsMember" xlink:to="loc_nymoxStockOptionsMember" order="11"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_DistributionAndAdministrativeExpense" xlink:label="loc_ifrs-fullDistributionAndAdministrativeExpense"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullDistributionAndAdministrativeExpense" order="1"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_ResearchAndDevelopmentExpense" xlink:label="loc_ifrs-fullResearchAndDevelopmentExpense"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullResearchAndDevelopmentExpense" order="2"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_AdjustmentsForSharebasedPayments1" xlink:label="loc_nymoxAdjustmentsForSharebasedPayments1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxAdjustmentsForSharebasedPayments1" order="3"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/ShareBasedCompensationDetailsNarrative" xlink:title="000069 - Disclosure - SHARE BASED COMPENSATION (Details Narrative)">
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementLineItems" xlink:label="loc_nymoxStatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementTable" xlink:label="loc_nymoxStatementTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStatementTable" order="2000" xbrldt:contextElement="segment" xbrldt:closed="true"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:label="loc_ifrs-fullCategoriesOfRelatedPartiesAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_nymoxStatementTable" xlink:to="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" order="10"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_EntitysTotalForRelatedPartiesMember" xlink:label="loc_ifrs-fullEntitysTotalForRelatedPartiesMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" xlink:to="loc_ifrs-fullEntitysTotalForRelatedPartiesMember" order="20"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_EntitysTotalForRelatedPartiesMember" xlink:label="loc_ifrs-fullEntitysTotalForRelatedPartiesMember_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" xlink:to="loc_ifrs-fullEntitysTotalForRelatedPartiesMember_10" order="30" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_DrAverbackMember" xlink:label="loc_nymoxDrAverbackMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullEntitysTotalForRelatedPartiesMember" xlink:to="loc_nymoxDrAverbackMember" order="11"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_SharesBasedCompensationRecognizedExpense" xlink:label="loc_nymoxSharesBasedCompensationRecognizedExpense"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxSharesBasedCompensationRecognizedExpense" order="1"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_SharesBasedCompensationUnrecognizedCompensation" xlink:label="loc_nymoxSharesBasedCompensationUnrecognizedCompensation"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxSharesBasedCompensationUnrecognizedCompensation" order="2"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_ReceviedForRestrictedShare" xlink:label="loc_nymoxReceviedForRestrictedShare"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxReceviedForRestrictedShare" order="3"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_ReceviedForRestrictedShareMonthly" xlink:label="loc_nymoxReceviedForRestrictedShareMonthly"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxReceviedForRestrictedShareMonthly" order="4"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_RerestrictedShares" xlink:label="loc_nymoxRerestrictedShares"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxRerestrictedShares" order="5"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_ParValuePerShare" xlink:label="loc_ifrs-fullParValuePerShare"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullParValuePerShare" order="6"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/WarrantsDetails" xlink:title="000070 - Disclosure - WARRANTS (Details)">
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementLineItems" xlink:label="loc_nymoxStatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementTable" xlink:label="loc_nymoxStatementTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStatementTable" order="2000" xbrldt:contextElement="segment" xbrldt:closed="true"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_ClassesOfShareCapitalAxis" xlink:label="loc_ifrs-fullClassesOfShareCapitalAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_nymoxStatementTable" xlink:to="loc_ifrs-fullClassesOfShareCapitalAxis" order="20"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_ClassesOfShareCapitalMember" xlink:label="loc_ifrs-fullClassesOfShareCapitalMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-fullClassesOfShareCapitalAxis" xlink:to="loc_ifrs-fullClassesOfShareCapitalMember" order="30"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_ClassesOfShareCapitalMember" xlink:label="loc_ifrs-fullClassesOfShareCapitalMember_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ifrs-fullClassesOfShareCapitalAxis" xlink:to="loc_ifrs-fullClassesOfShareCapitalMember_10" order="40" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_WarrantsMember" xlink:label="loc_nymoxWarrantsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullClassesOfShareCapitalMember" xlink:to="loc_nymoxWarrantsMember" order="21"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_WarrantsNumberOfOutstandingBalanceBeginning" xlink:label="loc_nymoxWarrantsNumberOfOutstandingBalanceBeginning"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxWarrantsNumberOfOutstandingBalanceBeginning" order="1"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_WarrantExercisedOutstandingShares" xlink:label="loc_nymoxWarrantExercisedOutstandingShares"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxWarrantExercisedOutstandingShares" order="2"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_WarrantGrantedOutstandingShares" xlink:label="loc_nymoxWarrantGrantedOutstandingShares"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxWarrantGrantedOutstandingShares" order="3"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_WarrantsNumberOfOutstandingBalanceEnding" xlink:label="loc_nymoxWarrantsNumberOfOutstandingBalanceEnding"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxWarrantsNumberOfOutstandingBalanceEnding" order="4"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_WarrantsWeightedAverageExercisePriceBeginning" xlink:label="loc_nymoxWarrantsWeightedAverageExercisePriceBeginning"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxWarrantsWeightedAverageExercisePriceBeginning" order="5"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_WarrantsWeightedAverageExercisePriceEnding" xlink:label="loc_nymoxWarrantsWeightedAverageExercisePriceEnding"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxWarrantsWeightedAverageExercisePriceEnding" order="6"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_WeightedAverageRemainingContractualLifeInYear" xlink:label="loc_nymoxWeightedAverageRemainingContractualLifeInYear"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxWeightedAverageRemainingContractualLifeInYear" order="7"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/WarrantsDetailsNarrative" xlink:title="000071 - Disclosure - WARRANTS (Details Narrative)">
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementLineItems" xlink:label="loc_nymoxStatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementTable" xlink:label="loc_nymoxStatementTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStatementTable" order="2000" xbrldt:contextElement="segment" xbrldt:closed="true"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_TypesOfContractsAxis" xlink:label="loc_ifrs-fullTypesOfContractsAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_nymoxStatementTable" xlink:to="loc_ifrs-fullTypesOfContractsAxis" order="20"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_TypesOfContractsMember" xlink:label="loc_ifrs-fullTypesOfContractsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-fullTypesOfContractsAxis" xlink:to="loc_ifrs-fullTypesOfContractsMember" order="30"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_TypesOfContractsMember" xlink:label="loc_ifrs-fullTypesOfContractsMember_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ifrs-fullTypesOfContractsAxis" xlink:to="loc_ifrs-fullTypesOfContractsMember_10" order="40" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_PrivatePlacementsMember" xlink:label="loc_nymoxPrivatePlacementsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullTypesOfContractsMember" xlink:to="loc_nymoxPrivatePlacementsMember" order="21"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_NumberOfWarrantsIssued" xlink:label="loc_nymoxNumberOfWarrantsIssued"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxNumberOfWarrantsIssued" order="1"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_ParValuePerShare" xlink:label="loc_ifrs-fullParValuePerShare"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullParValuePerShare" order="2"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_ProceesFromIssuanceOfWarrants" xlink:label="loc_nymoxProceesFromIssuanceOfWarrants"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxProceesFromIssuanceOfWarrants" order="3"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/IncomeTaxesDetails" xlink:title="000072 - Disclosure - INCOME TAXES (Details)">
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementLineItems" xlink:label="loc_nymoxStatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementTable" xlink:label="loc_nymoxStatementTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStatementTable" order="2000" xbrldt:contextElement="segment" xbrldt:closed="true"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_GeographicalAreasAxis" xlink:label="loc_ifrs-fullGeographicalAreasAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_nymoxStatementTable" xlink:to="loc_ifrs-fullGeographicalAreasAxis" order="20"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_GeographicalAreasMember" xlink:label="loc_ifrs-fullGeographicalAreasMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-fullGeographicalAreasAxis" xlink:to="loc_ifrs-fullGeographicalAreasMember" order="30"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_GeographicalAreasMember" xlink:label="loc_ifrs-fullGeographicalAreasMember_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ifrs-fullGeographicalAreasAxis" xlink:to="loc_ifrs-fullGeographicalAreasMember_10" order="40" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_BahamasMember" xlink:label="loc_nymoxBahamasMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullGeographicalAreasMember" xlink:to="loc_nymoxBahamasMember" order="21"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_UnitedStatesMember" xlink:label="loc_nymoxUnitedStatesMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullGeographicalAreasMember" xlink:to="loc_nymoxUnitedStatesMember" order="22"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_ProfitLossBeforeTaxes" xlink:label="loc_nymoxProfitLossBeforeTaxes"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxProfitLossBeforeTaxes" order="1"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_TaxRateEffectOfForeignTaxRates" xlink:label="loc_ifrs-fullTaxRateEffectOfForeignTaxRates"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullTaxRateEffectOfForeignTaxRates" order="2"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_IncomeTaxesAtDomesticTaxStatutoryRate" xlink:label="loc_nymoxIncomeTaxesAtDomesticTaxStatutoryRate"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxIncomeTaxesAtDomesticTaxStatutoryRate" order="3"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_ChangeInValuationAllowance" xlink:label="loc_nymoxChangeInValuationAllowance"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxChangeInValuationAllowance" order="4"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_DeferredTaxProvisionRecovery" xlink:label="loc_nymoxDeferredTaxProvisionRecovery"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxDeferredTaxProvisionRecovery" order="5"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/IncomeTaxesDetails1" xlink:title="000073 - Disclosure - INCOME TAXES (Details 1)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/IncomeTaxesDetails2" xlink:title="000074 - Disclosure - INCOME TAXES (Details 2)">
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementLineItems" xlink:label="loc_nymoxStatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementTable" xlink:label="loc_nymoxStatementTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStatementTable" order="2000" xbrldt:contextElement="segment" xbrldt:closed="true"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_CreationDateAxis" xlink:label="loc_ifrs-fullCreationDateAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_nymoxStatementTable" xlink:to="loc_ifrs-fullCreationDateAxis" order="10"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_DefaultFinancialStatementsDateMember" xlink:label="loc_ifrs-fullDefaultFinancialStatementsDateMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-fullCreationDateAxis" xlink:to="loc_ifrs-fullDefaultFinancialStatementsDateMember" order="20"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_DefaultFinancialStatementsDateMember" xlink:label="loc_ifrs-fullDefaultFinancialStatementsDateMember_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ifrs-fullCreationDateAxis" xlink:to="loc_ifrs-fullDefaultFinancialStatementsDateMember_10" order="30" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_TwoThousandTwentyMember" xlink:label="loc_nymoxTwoThousandTwentyMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullDefaultFinancialStatementsDateMember" xlink:to="loc_nymoxTwoThousandTwentyMember" order="11"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_TwoThousandNineMember" xlink:label="loc_nymoxTwoThousandNineMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullDefaultFinancialStatementsDateMember" xlink:to="loc_nymoxTwoThousandNineMember" order="12"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_TweentyHundredZeroOneMember" xlink:label="loc_nymoxTweentyHundredZeroOneMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullDefaultFinancialStatementsDateMember" xlink:to="loc_nymoxTweentyHundredZeroOneMember" order="13"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_TweentyHundredZeroTwoMember" xlink:label="loc_nymoxTweentyHundredZeroTwoMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullDefaultFinancialStatementsDateMember" xlink:to="loc_nymoxTweentyHundredZeroTwoMember" order="14"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_TweentyHundredZeroThreeMember" xlink:label="loc_nymoxTweentyHundredZeroThreeMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullDefaultFinancialStatementsDateMember" xlink:to="loc_nymoxTweentyHundredZeroThreeMember" order="15"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_TweentyHundredZeroFourMember" xlink:label="loc_nymoxTweentyHundredZeroFourMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullDefaultFinancialStatementsDateMember" xlink:to="loc_nymoxTweentyHundredZeroFourMember" order="16"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_TweentyHundredZeroFiveMember" xlink:label="loc_nymoxTweentyHundredZeroFiveMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullDefaultFinancialStatementsDateMember" xlink:to="loc_nymoxTweentyHundredZeroFiveMember" order="17"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_TweentyHundredZeroSixMember" xlink:label="loc_nymoxTweentyHundredZeroSixMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullDefaultFinancialStatementsDateMember" xlink:to="loc_nymoxTweentyHundredZeroSixMember" order="18"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_TweentyHundredZeroSevenMember" xlink:label="loc_nymoxTweentyHundredZeroSevenMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullDefaultFinancialStatementsDateMember" xlink:to="loc_nymoxTweentyHundredZeroSevenMember" order="19"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_TweentyHundredZeroEightMember" xlink:label="loc_nymoxTweentyHundredZeroEightMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullDefaultFinancialStatementsDateMember" xlink:to="loc_nymoxTweentyHundredZeroEightMember" order="20"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_TweentyHundredTenMember" xlink:label="loc_nymoxTweentyHundredTenMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullDefaultFinancialStatementsDateMember" xlink:to="loc_nymoxTweentyHundredTenMember" order="21"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_TweentyHundredElevenMember" xlink:label="loc_nymoxTweentyHundredElevenMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullDefaultFinancialStatementsDateMember" xlink:to="loc_nymoxTweentyHundredElevenMember" order="22"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_TweentyHundredTwelveMember" xlink:label="loc_nymoxTweentyHundredTwelveMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullDefaultFinancialStatementsDateMember" xlink:to="loc_nymoxTweentyHundredTwelveMember" order="23"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_TweentyHundredThirteenMember" xlink:label="loc_nymoxTweentyHundredThirteenMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullDefaultFinancialStatementsDateMember" xlink:to="loc_nymoxTweentyHundredThirteenMember" order="24"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_TweentyHundredFourteenMember" xlink:label="loc_nymoxTweentyHundredFourteenMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullDefaultFinancialStatementsDateMember" xlink:to="loc_nymoxTweentyHundredFourteenMember" order="25"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_TweentyHundredFifteenMember" xlink:label="loc_nymoxTweentyHundredFifteenMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullDefaultFinancialStatementsDateMember" xlink:to="loc_nymoxTweentyHundredFifteenMember" order="26"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_TweentyHundredSixteenMember" xlink:label="loc_nymoxTweentyHundredSixteenMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullDefaultFinancialStatementsDateMember" xlink:to="loc_nymoxTweentyHundredSixteenMember" order="27"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_TweentyHundredSeventeenMember" xlink:label="loc_nymoxTweentyHundredSeventeenMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullDefaultFinancialStatementsDateMember" xlink:to="loc_nymoxTweentyHundredSeventeenMember" order="28"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_TweentyHundredEighteenMember" xlink:label="loc_nymoxTweentyHundredEighteenMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullDefaultFinancialStatementsDateMember" xlink:to="loc_nymoxTweentyHundredEighteenMember" order="29"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_TwoHundredNineteenMember" xlink:label="loc_nymoxTwoHundredNineteenMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullDefaultFinancialStatementsDateMember" xlink:to="loc_nymoxTwoHundredNineteenMember" order="30"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_NetOperatingLossCarryforwardsForUsFederalIncomeTax" xlink:label="loc_nymoxNetOperatingLossCarryforwardsForUsFederalIncomeTax"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxNetOperatingLossCarryforwardsForUsFederalIncomeTax" order="1"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_OperatingLossCarryforwardsOriginatedDate" xlink:label="loc_nymoxOperatingLossCarryforwardsOriginatedDate"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxOperatingLossCarryforwardsOriginatedDate" order="2"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_OperatingLossCarryforwardExpirationDate" xlink:label="loc_nymoxOperatingLossCarryforwardExpirationDate"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxOperatingLossCarryforwardExpirationDate" order="3"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/IncomeTaxesDetailsNarrative" xlink:title="000075 - Disclosure - INCOME TAXES (Details Narrative)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/EarningsPerShareDetails" xlink:title="000076 - Disclosure - EARNINGS PER SHARE (Details)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/FinanceIncomeAndFinanceCostsDetails" xlink:title="000077 - Disclosure - FINANCE INCOME AND FINANCE COSTS (Details)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/SegmentDisclosuresDetails" xlink:title="000078 - Disclosure - SEGMENT DISCLOSURES (Details)">
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementLineItems" xlink:label="loc_nymoxStatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementTable" xlink:label="loc_nymoxStatementTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStatementTable" order="2000" xbrldt:contextElement="segment" xbrldt:closed="true"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_GeographicalAreasAxis" xlink:label="loc_ifrs-fullGeographicalAreasAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_nymoxStatementTable" xlink:to="loc_ifrs-fullGeographicalAreasAxis" order="10"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_GeographicalAreasMember" xlink:label="loc_ifrs-fullGeographicalAreasMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-fullGeographicalAreasAxis" xlink:to="loc_ifrs-fullGeographicalAreasMember" order="20"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_GeographicalAreasMember" xlink:label="loc_ifrs-fullGeographicalAreasMember_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ifrs-fullGeographicalAreasAxis" xlink:to="loc_ifrs-fullGeographicalAreasMember_10" order="30" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_GeographicalAreasUnitedStatesMember" xlink:label="loc_nymoxGeographicalAreasUnitedStatesMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullGeographicalAreasMember" xlink:to="loc_nymoxGeographicalAreasUnitedStatesMember" order="11"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_GeographicalAreasEuropeMember" xlink:label="loc_nymoxGeographicalAreasEuropeMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullGeographicalAreasMember" xlink:to="loc_nymoxGeographicalAreasEuropeMember" order="12"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_GeographicalAreasCanadaMember" xlink:label="loc_nymoxGeographicalAreasCanadaMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullGeographicalAreasMember" xlink:to="loc_nymoxGeographicalAreasCanadaMember" order="13"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_Revenue" xlink:label="loc_ifrs-fullRevenue"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullRevenue" order="1"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_PropertyPlantAndEquipment" xlink:label="loc_ifrs-fullPropertyPlantAndEquipment"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullPropertyPlantAndEquipment" order="2"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/ConcentrationsDetails" xlink:title="000079 - Disclosure - CONCENTRATIONS (Details)">
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementLineItems" xlink:label="loc_nymoxStatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementTable" xlink:label="loc_nymoxStatementTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStatementTable" order="2000" xbrldt:contextElement="segment" xbrldt:closed="true"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_MarketsOfCustomersAxis" xlink:label="loc_ifrs-fullMarketsOfCustomersAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_nymoxStatementTable" xlink:to="loc_ifrs-fullMarketsOfCustomersAxis" order="20"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_MarketsOfCustomersMember" xlink:label="loc_ifrs-fullMarketsOfCustomersMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-fullMarketsOfCustomersAxis" xlink:to="loc_ifrs-fullMarketsOfCustomersMember" order="30"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_MarketsOfCustomersMember" xlink:label="loc_ifrs-fullMarketsOfCustomersMember_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ifrs-fullMarketsOfCustomersAxis" xlink:to="loc_ifrs-fullMarketsOfCustomersMember_10" order="40" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_CustomersAMember" xlink:label="loc_nymoxCustomersAMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullMarketsOfCustomersMember" xlink:to="loc_nymoxCustomersAMember" order="21"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_CustomersBMember" xlink:label="loc_nymoxCustomersBMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullMarketsOfCustomersMember" xlink:to="loc_nymoxCustomersBMember" order="22"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_CustomersCMember" xlink:label="loc_nymoxCustomersCMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullMarketsOfCustomersMember" xlink:to="loc_nymoxCustomersCMember" order="23"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_RevenueFromSaleOfGoods" xlink:label="loc_ifrs-fullRevenueFromSaleOfGoods"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullRevenueFromSaleOfGoods" order="1"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/RelatedPartyTransactionsDetails" xlink:title="000080 - Disclosure - RELATED PARTY TRANSACTIONS (Details)">
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementLineItems" xlink:label="loc_nymoxStatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementTable" xlink:label="loc_nymoxStatementTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStatementTable" order="2000" xbrldt:contextElement="segment" xbrldt:closed="true"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:label="loc_ifrs-fullCategoriesOfRelatedPartiesAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_nymoxStatementTable" xlink:to="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" order="10"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_EntitysTotalForRelatedPartiesMember" xlink:label="loc_ifrs-fullEntitysTotalForRelatedPartiesMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" xlink:to="loc_ifrs-fullEntitysTotalForRelatedPartiesMember" order="20"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_EntitysTotalForRelatedPartiesMember" xlink:label="loc_ifrs-fullEntitysTotalForRelatedPartiesMember_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" xlink:to="loc_ifrs-fullEntitysTotalForRelatedPartiesMember_10" order="30" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_OfficersAndDirectorsMember" xlink:label="loc_nymoxOfficersAndDirectorsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullEntitysTotalForRelatedPartiesMember" xlink:to="loc_nymoxOfficersAndDirectorsMember" order="11"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_WagesAndSalaries" xlink:label="loc_ifrs-fullWagesAndSalaries"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullWagesAndSalaries" order="1"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_KeyManagementPersonnelCompensationShorttermEmployeeBenefits" xlink:label="loc_ifrs-fullKeyManagementPersonnelCompensationShorttermEmployeeBenefits"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullKeyManagementPersonnelCompensationShorttermEmployeeBenefits" order="2"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_KeyManagementPersonnelCompensationSharebasedPayment" xlink:label="loc_ifrs-fullKeyManagementPersonnelCompensationSharebasedPayment"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullKeyManagementPersonnelCompensationSharebasedPayment" order="3"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_KeyManagementPersonnelCompensation" xlink:label="loc_ifrs-fullKeyManagementPersonnelCompensation"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullKeyManagementPersonnelCompensation" order="4"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/RelatedPartyTransactionsDetailsNarrative" xlink:title="000081 - Disclosure - RELATED PARTY TRANSACTIONS (Details Narrative)">
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementLineItems" xlink:label="loc_nymoxStatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementTable" xlink:label="loc_nymoxStatementTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStatementTable" order="2000" xbrldt:contextElement="segment" xbrldt:closed="true"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:label="loc_ifrs-fullCategoriesOfRelatedPartiesAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_nymoxStatementTable" xlink:to="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" order="10"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_EntitysTotalForRelatedPartiesMember" xlink:label="loc_ifrs-fullEntitysTotalForRelatedPartiesMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" xlink:to="loc_ifrs-fullEntitysTotalForRelatedPartiesMember" order="20"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_EntitysTotalForRelatedPartiesMember" xlink:label="loc_ifrs-fullEntitysTotalForRelatedPartiesMember_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" xlink:to="loc_ifrs-fullEntitysTotalForRelatedPartiesMember_10" order="30" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_ChiefFinancialOfficersMember" xlink:label="loc_nymoxChiefFinancialOfficersMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullEntitysTotalForRelatedPartiesMember" xlink:to="loc_nymoxChiefFinancialOfficersMember" order="11"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_CorporateLegalCounselMember" xlink:label="loc_nymoxCorporateLegalCounselMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullEntitysTotalForRelatedPartiesMember" xlink:to="loc_nymoxCorporateLegalCounselMember" order="12"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_IndependentDirectorsMember" xlink:label="loc_nymoxIndependentDirectorsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullEntitysTotalForRelatedPartiesMember" xlink:to="loc_nymoxIndependentDirectorsMember" order="13"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_AmountsPayableRelatedPartyTransactions" xlink:label="loc_ifrs-fullAmountsPayableRelatedPartyTransactions"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullAmountsPayableRelatedPartyTransactions" order="1"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_TotalHonorariums" xlink:label="loc_nymoxTotalHonorariums"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxTotalHonorariums" order="2"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/ResearchAndDevelopmentExpensesDetails" xlink:title="000082 - Disclosure - RESEARCH AND DEVELOPMENT EXPENSES (Details)">
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementLineItems" xlink:label="loc_nymoxStatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementTable" xlink:label="loc_nymoxStatementTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStatementTable" order="2000" xbrldt:contextElement="segment" xbrldt:closed="true"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_ProductsAndServicesAxis" xlink:label="loc_ifrs-fullProductsAndServicesAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_nymoxStatementTable" xlink:to="loc_ifrs-fullProductsAndServicesAxis" order="20"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_ProductsAndServicesMember" xlink:label="loc_ifrs-fullProductsAndServicesMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-fullProductsAndServicesAxis" xlink:to="loc_ifrs-fullProductsAndServicesMember" order="30"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_ProductsAndServicesMember" xlink:label="loc_ifrs-fullProductsAndServicesMember_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ifrs-fullProductsAndServicesAxis" xlink:to="loc_ifrs-fullProductsAndServicesMember_10" order="40" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_SignificantInvestmentsInAssociatesAxis" xlink:label="loc_ifrs-fullSignificantInvestmentsInAssociatesAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_nymoxStatementTable" xlink:to="loc_ifrs-fullSignificantInvestmentsInAssociatesAxis" order="40"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_EntitysTotalForAssociatesMember" xlink:label="loc_ifrs-fullEntitysTotalForAssociatesMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-fullSignificantInvestmentsInAssociatesAxis" xlink:to="loc_ifrs-fullEntitysTotalForAssociatesMember" order="50"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_EntitysTotalForAssociatesMember" xlink:label="loc_ifrs-fullEntitysTotalForAssociatesMember_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ifrs-fullSignificantInvestmentsInAssociatesAxis" xlink:to="loc_ifrs-fullEntitysTotalForAssociatesMember_10" order="60" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_ResearchAndDevelopmentProgramMember" xlink:label="loc_nymoxResearchAndDevelopmentProgramMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullProductsAndServicesMember" xlink:to="loc_nymoxResearchAndDevelopmentProgramMember" order="41"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_AlzheimersDiseaseTherapeuticsMember" xlink:label="loc_nymoxAlzheimersDiseaseTherapeuticsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullEntitysTotalForAssociatesMember" xlink:to="loc_nymoxAlzheimersDiseaseTherapeuticsMember" order="42"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_AntiInfectivesMember" xlink:label="loc_nymoxAntiInfectivesMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullEntitysTotalForAssociatesMember" xlink:to="loc_nymoxAntiInfectivesMember" order="43"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_BPHEnlargedProstateAndProstateCancerTherapeuticsMember" xlink:label="loc_nymoxBPHEnlargedProstateAndProstateCancerTherapeuticsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullEntitysTotalForAssociatesMember" xlink:to="loc_nymoxBPHEnlargedProstateAndProstateCancerTherapeuticsMember" order="44"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_TobaccoExposureTestsMember" xlink:label="loc_nymoxTobaccoExposureTestsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullEntitysTotalForAssociatesMember" xlink:to="loc_nymoxTobaccoExposureTestsMember" order="45"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_PaymentsForDevelopmentProjectExpenditure" xlink:label="loc_ifrs-fullPaymentsForDevelopmentProjectExpenditure"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullPaymentsForDevelopmentProjectExpenditure" order="1"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/PersonnelExpensesDetails" xlink:title="000083 - Disclosure - PERSONNEL EXPENSES (Details)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/PersonnelExpensesDetailsNarrative" xlink:title="000084 - Disclosure - PERSONNEL EXPENSES (Details Narrative)">
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementLineItems" xlink:label="loc_nymoxStatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementTable" xlink:label="loc_nymoxStatementTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStatementTable" order="2000" xbrldt:contextElement="segment" xbrldt:closed="true"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_ClassesOfAssetsAxis" xlink:label="loc_ifrs-fullClassesOfAssetsAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_nymoxStatementTable" xlink:to="loc_ifrs-fullClassesOfAssetsAxis" order="10"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_ClassesOfAssetsMember" xlink:label="loc_ifrs-fullClassesOfAssetsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-fullClassesOfAssetsAxis" xlink:to="loc_ifrs-fullClassesOfAssetsMember" order="20"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_ClassesOfAssetsMember" xlink:label="loc_ifrs-fullClassesOfAssetsMember_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ifrs-fullClassesOfAssetsAxis" xlink:to="loc_ifrs-fullClassesOfAssetsMember_10" order="30" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_GeneralandAdminstrativeMember" xlink:label="loc_nymoxGeneralandAdminstrativeMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullClassesOfAssetsMember" xlink:to="loc_nymoxGeneralandAdminstrativeMember" order="11"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_Salaries" xlink:label="loc_nymoxSalaries"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxSalaries" order="1"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StockbasedCompensation" xlink:label="loc_nymoxStockbasedCompensation"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStockbasedCompensation" order="2"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/CapitalDisclosuresAndFinancialRiskDetailsNarrative" xlink:title="000085 - Disclosure - CAPITAL DISCLOSURES AND FINANCIAL RISK (Details Narrative)">
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementLineItems" xlink:label="loc_nymoxStatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementTable" xlink:label="loc_nymoxStatementTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStatementTable" order="2000" xbrldt:contextElement="segment" xbrldt:closed="true"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_TypesOfContractsAxis" xlink:label="loc_ifrs-fullTypesOfContractsAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_nymoxStatementTable" xlink:to="loc_ifrs-fullTypesOfContractsAxis" order="10"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_TypesOfContractsMember" xlink:label="loc_ifrs-fullTypesOfContractsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-fullTypesOfContractsAxis" xlink:to="loc_ifrs-fullTypesOfContractsMember" order="20"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_TypesOfContractsMember" xlink:label="loc_ifrs-fullTypesOfContractsMember_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ifrs-fullTypesOfContractsAxis" xlink:to="loc_ifrs-fullTypesOfContractsMember_10" order="30" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_PrivatePlacementMember" xlink:label="loc_nymoxPrivatePlacementMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullTypesOfContractsMember" xlink:to="loc_nymoxPrivatePlacementMember" order="11"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_PercentagesOfExpenses" xlink:label="loc_nymoxPercentagesOfExpenses"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxPercentagesOfExpenses" order="1"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_AmountOfIssuanceOfShareCapital" xlink:label="loc_nymoxAmountOfIssuanceOfShareCapital"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxAmountOfIssuanceOfShareCapital" order="2"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_IssuanceOfShareCapital" xlink:label="loc_nymoxIssuanceOfShareCapital"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxIssuanceOfShareCapital" order="3"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_CommonSharesIssued" xlink:label="loc_nymoxCommonSharesIssued"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxCommonSharesIssued" order="4"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/ForeignExchangeRiskDetailsNarrative" xlink:title="000086 - Disclosure - FOREIGN EXCHANGE RISK (Details Narrative)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/CreditRiskDetailsNarrative" xlink:title="000087 - Disclosure - CREDIT RISK (Details Narrative)">
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementLineItems" xlink:label="loc_nymoxStatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementTable" xlink:label="loc_nymoxStatementTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStatementTable" order="2000" xbrldt:contextElement="segment" xbrldt:closed="true"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_TypesOfCustomersAxis" xlink:label="loc_ifrs-fullTypesOfCustomersAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_nymoxStatementTable" xlink:to="loc_ifrs-fullTypesOfCustomersAxis" order="20"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_TypesOfCustomersMember" xlink:label="loc_ifrs-fullTypesOfCustomersMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-fullTypesOfCustomersAxis" xlink:to="loc_ifrs-fullTypesOfCustomersMember" order="30"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_TypesOfCustomersMember" xlink:label="loc_ifrs-fullTypesOfCustomersMember_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ifrs-fullTypesOfCustomersAxis" xlink:to="loc_ifrs-fullTypesOfCustomersMember_10" order="40" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_TwoCustomerMember" xlink:label="loc_nymoxTwoCustomerMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullTypesOfCustomersMember" xlink:to="loc_nymoxTwoCustomerMember" order="21"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_TradeReceivables" xlink:label="loc_ifrs-fullTradeReceivables"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullTradeReceivables" order="1"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_TradeReceivablesPercentage" xlink:label="loc_nymoxTradeReceivablesPercentage"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxTradeReceivablesPercentage" order="2"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/InterestRateRiskDetailsNarrative" xlink:title="000088 - Disclosure - INTEREST RATE RISK (Details Narrative)"/>
<link:definitionLink xlink:type="extended" xlink:role="http://nymox.com/role/LiquidityRiskDetails" xlink:title="000089 - Disclosure - LIQUIDITY RISK (Details)">
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementLineItems" xlink:label="loc_nymoxStatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_StatementTable" xlink:label="loc_nymoxStatementTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_nymoxStatementTable" order="2000" xbrldt:contextElement="segment" xbrldt:closed="true"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_CarryingAmountAccumulatedDepreciationAmortisationAndImpairmentAndGrossCarryingAmountAxis" xlink:label="loc_ifrs-fullCarryingAmountAccumulatedDepreciationAmortisationAndImpairmentAndGrossCarryingAmountAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_nymoxStatementTable" xlink:to="loc_ifrs-fullCarryingAmountAccumulatedDepreciationAmortisationAndImpairmentAndGrossCarryingAmountAxis" order="20"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_CarryingAmountMember" xlink:label="loc_ifrs-fullCarryingAmountMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-fullCarryingAmountAccumulatedDepreciationAmortisationAndImpairmentAndGrossCarryingAmountAxis" xlink:to="loc_ifrs-fullCarryingAmountMember" order="30"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_CarryingAmountMember" xlink:label="loc_ifrs-fullCarryingAmountMember_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ifrs-fullCarryingAmountAccumulatedDepreciationAmortisationAndImpairmentAndGrossCarryingAmountAxis" xlink:to="loc_ifrs-fullCarryingAmountMember_10" order="40" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_MaturityAxis" xlink:label="loc_ifrs-fullMaturityAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_nymoxStatementTable" xlink:to="loc_ifrs-fullMaturityAxis" order="40"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_AggregatedTimeBandsMember" xlink:label="loc_ifrs-fullAggregatedTimeBandsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-fullMaturityAxis" xlink:to="loc_ifrs-fullAggregatedTimeBandsMember" order="50"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_AggregatedTimeBandsMember" xlink:label="loc_ifrs-fullAggregatedTimeBandsMember_10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_ifrs-fullMaturityAxis" xlink:to="loc_ifrs-fullAggregatedTimeBandsMember_10" order="60" xbrldt:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_CarryingAmountsMember" xlink:label="loc_nymoxCarryingAmountsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullCarryingAmountMember" xlink:to="loc_nymoxCarryingAmountsMember" order="41"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_LessThanOneYearMember" xlink:label="loc_nymoxLessThanOneYearMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullAggregatedTimeBandsMember" xlink:to="loc_nymoxLessThanOneYearMember" order="42"/>
<link:loc xlink:type="locator" xlink:href="nymox-20201231.xsd#nymox_OneyearToFiveYearsMember" xlink:label="loc_nymoxOneyearToFiveYearsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-fullAggregatedTimeBandsMember" xlink:to="loc_nymoxOneyearToFiveYearsMember" order="43"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.ifrs.org/taxonomy/2019-03-27/full_ifrs/full_ifrs-cor_2019-03-27.xsd#ifrs-full_TradeAndOtherCurrentPayables" xlink:label="loc_ifrs-fullTradeAndOtherCurrentPayables"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_nymoxStatementLineItems" xlink:to="loc_ifrs-fullTradeAndOtherCurrentPayables" order="1"/>
</link:definitionLink>
</link:linkbase>


4 Previous Filings that this Filing References

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 3/31/16  Nymox Pharmaceutical Corp.        20-F       12/31/15    8:1.2M                                   e3 Fil… Computershare/FA
 6/03/11  Nymox Pharmaceutical Corp.        20-F/A     12/31/10    7:474K                                   e3 Fil… Computershare/FA
 6/30/04  Nymox Pharmaceutical Corp.        20-F       12/31/03    7:1.1M                                   Foley & Lardner/FA
 6/27/02  Nymox Pharmaceutical Corp.        20-F       12/31/01    2:246K                                   Foley & Lardner/FA
Top
Filing Submission 0001640334-21-000680   –   Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)

Copyright © 2024 Fran Finnegan & Company LLC – All Rights Reserved.
AboutPrivacyRedactionsHelp — Wed., Apr. 24, 3:39:35.2am ET