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Mimedx Group, Inc. – ‘10-K’ for 12/31/12 – ‘EX-101.DEF’

On:  Friday, 3/15/13, at 5:14pm ET   ·   For:  12/31/12   ·   Accession #:  1140361-13-12765   ·   File #:  0-52491

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  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 3/15/13  Mimedx Group, Inc.                10-K       12/31/12   70:10M                                    Broadridge Fin’l So… Inc

Annual Report   —   Form 10-K   —   Sect. 13 / 15(d) – SEA’34
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-K        Mimedx Group Inc 10-K 12-31-2012                    HTML   1.04M 
 2: EX-10.54    Material Contract                                   HTML     39K 
 3: EX-10.55    Material Contract                                   HTML     27K 
 4: EX-10.56    Material Contract                                   HTML     96K 
 5: EX-23.1     Consent of Experts or Counsel                       HTML     19K 
 6: EX-31.1     Certification -- §302 - SOA'02                      HTML     27K 
 7: EX-31.2     Certification -- §302 - SOA'02                      HTML     27K 
 8: EX-32.1     Certification -- §906 - SOA'02                      HTML     21K 
 9: EX-32.2     Certification -- §906 - SOA'02                      HTML     21K 
47: R1          Document and Entity Information                     HTML     48K 
37: R2          Consolidated Balance Sheets                         HTML    126K 
45: R3          Consolidated Balance Sheets (Parenthetical)         HTML     56K 
49: R4          Consolidated Statements of Operations               HTML     70K 
64: R5          Consolidated Statements of Stockholders' Equity     HTML    130K 
39: R6          Consolidated Statements of Stockholders' Equity     HTML     22K 
                (Parenthetical)                                                  
44: R7          Consolidated Statements of Cash Flows               HTML    150K 
34: R8          Consolidated Statements of Cash Flows               HTML     76K 
                (Parenthetical)                                                  
26: R9          Nature of Business                                  HTML     24K 
66: R10         Significant Accounting Policies                     HTML    124K 
51: R11         Liquidity and Management's Plans                    HTML     22K 
50: R12         Acquisition of Surgical Biologics, LLC              HTML     85K 
55: R13         Inventories                                         HTML     33K 
56: R14         Property and Equipment                              HTML     36K 
54: R15         Intangible Assets and Royalty Agreement             HTML     96K 
57: R16         Accrued Expenses                                    HTML     30K 
46: R17         Long-Term Debt                                      HTML     54K 
48: R18         Common Stock Placements                             HTML     36K 
53: R19         Equity                                              HTML    185K 
70: R20         Income Taxes                                        HTML     58K 
60: R21         Related Party Transactions                          HTML     38K 
41: R22         401k Plan                                           HTML     30K 
52: R23         Commitments                                         HTML     30K 
43: R24         Subsequent Events                                   HTML     24K 
20: R25         Significant Accounting Policies (Policies)          HTML    222K 
61: R26         Significant Accounting Policies (Tables)            HTML     65K 
67: R27         Acquisition of Surgical Biologics, LLC (Tables)     HTML     72K 
30: R28         Inventories (Tables)                                HTML     30K 
29: R29         Property and Equipment (Tables)                     HTML     33K 
32: R30         Intangible Assets and Royalty Agreement (Tables)    HTML     96K 
33: R31         Accrued Expenses (Tables)                           HTML     27K 
35: R32         Long-Term Debt (Tables)                             HTML     47K 
19: R33         Equity (Tables)                                     HTML    182K 
58: R34         Income Taxes (Tables)                               HTML     50K 
40: R35         Related Party Transactions (Tables)                 HTML     33K 
42: R36         Commitments (Tables)                                HTML     25K 
23: R37         Nature of Business (Details)                        HTML     21K 
69: R38         Significant Accounting Policies (Details)           HTML    157K 
16: R39         Liquidity and Management's Plans (Details)          HTML     31K 
36: R40         Acquisition of Surgical Biologics, LLC (Details)    HTML    177K 
63: R41         Inventories (Details)                               HTML     38K 
22: R42         Property and Equipment (Details)                    HTML     34K 
28: R43         Intangible Assets and Royalty Agreement (Details)   HTML    122K 
31: R44         Accrued Expenses (Details)                          HTML     31K 
38: R45         Long-Term Debt (Details)                            HTML    116K 
18: R46         Common Stock Placements (Details)                   HTML     70K 
25: R47         Equity (Details)                                    HTML    285K 
17: R48         Income Taxes (Details)                              HTML     95K 
62: R49         Related Party Transactions (Details)                HTML     31K 
21: R50         401k Plan (Details)                                 HTML     32K 
59: R51         Commitments (Details)                               HTML     28K 
24: R52         Subsequent Events (Details)                         HTML     37K 
68: XML         IDEA XML File -- Filing Summary                      XML     94K 
27: EXCEL       IDEA Workbook of Financial Reports (.xls)            XLS   1.52M 
10: EX-101.INS  XBRL Instance -- mdxg-20121231                       XML   2.21M 
12: EX-101.CAL  XBRL Calculations -- mdxg-20121231_cal               XML    193K 
13: EX-101.DEF  XBRL Definitions -- mdxg-20121231_def                XML    640K 
14: EX-101.LAB  XBRL Labels -- mdxg-20121231_lab                     XML   2.22M 
15: EX-101.PRE  XBRL Presentations -- mdxg-20121231_pre              XML   1.17M 
11: EX-101.SCH  XBRL Schema -- mdxg-20121231                         XSD    203K 
65: ZIP         XBRL Zipped Folder -- 0001140361-13-012765-xbrl      Zip    225K

‘EX-101.DEF’   —   XBRL Definitions — mdxg-20121231_def

This Exhibit is an XBRL XML File.

                                                                                                                                                                                
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionCostOfAcquiredEntityConvertibleSecuredPromissoryNote" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionCostOfAcquiredEntityConvertibleSecuredPromissoryNote" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="DebtInstrumentInterestRateStatedPercentage" xlink:title="DebtInstrumentInterestRateStatedPercentage"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="DebtInstrumentInterestRateStatedPercentage" xlink:title="definition: BusinessAcquisitionLineItems to DebtInstrumentInterestRateStatedPercentage" order="3.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned" xlink:label="BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned" xlink:title="BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned" order="4.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued" xlink:label="BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued" xlink:title="BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued" order="5.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_BusinessAcquisitionEquityInterestIssuedOrIssuableValuePerShare" xlink:label="BusinessAcquisitionEquityInterestIssuedOrIssuableValuePerShare" xlink:title="BusinessAcquisitionEquityInterestIssuedOrIssuableValuePerShare"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionEquityInterestIssuedOrIssuableValuePerShare" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionEquityInterestIssuedOrIssuableValuePerShare" order="6.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_CommonStockHeldInEscrowShares" xlink:label="CommonStockHeldInEscrowShares" xlink:title="CommonStockHeldInEscrowShares"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="CommonStockHeldInEscrowShares" xlink:title="definition: BusinessAcquisitionLineItems to CommonStockHeldInEscrowShares" order="7.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionPrice1" xlink:label="DebtInstrumentConvertibleConversionPrice1" xlink:title="DebtInstrumentConvertibleConversionPrice1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="DebtInstrumentConvertibleConversionPrice1" xlink:title="definition: BusinessAcquisitionLineItems to DebtInstrumentConvertibleConversionPrice1" order="8.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtInstrumentConvertibleStockPriceTrigger" xlink:label="DebtInstrumentConvertibleStockPriceTrigger" xlink:title="DebtInstrumentConvertibleStockPriceTrigger"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="DebtInstrumentConvertibleStockPriceTrigger" xlink:title="definition: BusinessAcquisitionLineItems to DebtInstrumentConvertibleStockPriceTrigger" order="9.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_MinimumNumberOfConsecutiveTradingDaysConsideredForClosingTradingPrice" xlink:label="MinimumNumberOfConsecutiveTradingDaysConsideredForClosingTradingPrice" xlink:title="MinimumNumberOfConsecutiveTradingDaysConsideredForClosingTradingPrice"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="MinimumNumberOfConsecutiveTradingDaysConsideredForClosingTradingPrice" xlink:title="definition: BusinessAcquisitionLineItems to MinimumNumberOfConsecutiveTradingDaysConsideredForClosingTradingPrice" order="10.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_DebtInstrumentMaturityPeriod" xlink:label="DebtInstrumentMaturityPeriod" xlink:title="DebtInstrumentMaturityPeriod"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="DebtInstrumentMaturityPeriod" xlink:title="definition: BusinessAcquisitionLineItems to DebtInstrumentMaturityPeriod" order="11.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RepaymentsOfConvertibleDebt" xlink:label="RepaymentsOfConvertibleDebt" xlink:title="RepaymentsOfConvertibleDebt"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="RepaymentsOfConvertibleDebt" xlink:title="definition: BusinessAcquisitionLineItems to RepaymentsOfConvertibleDebt" order="12.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_MovementInValuationAllowancesAndReservesRollForward" xlink:label="MovementInValuationAllowancesAndReservesRollForward" xlink:title="MovementInValuationAllowancesAndReservesRollForward"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="MovementInValuationAllowancesAndReservesRollForward" xlink:title="definition: BusinessAcquisitionLineItems to MovementInValuationAllowancesAndReservesRollForward" order="13.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationAbstract" xlink:label="BusinessAcquisitionPurchasePriceAllocationAbstract" xlink:title="BusinessAcquisitionPurchasePriceAllocationAbstract"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionPurchasePriceAllocationAbstract" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionPurchasePriceAllocationAbstract" order="14.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuable" xlink:label="BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuable" xlink:title="BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuable" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuable" order="15.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionCostOfAcquiredEntityCashPaid" xlink:label="BusinessAcquisitionCostOfAcquiredEntityCashPaid" xlink:title="BusinessAcquisitionCostOfAcquiredEntityCashPaid"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionCostOfAcquiredEntityCashPaid" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionCostOfAcquiredEntityCashPaid" order="16.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_BusinessAcquisitionCashRetainedForWorkingCapital" xlink:label="BusinessAcquisitionCashRetainedForWorkingCapital" xlink:title="BusinessAcquisitionCashRetainedForWorkingCapital"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionCashRetainedForWorkingCapital" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionCashRetainedForWorkingCapital" order="17.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationLiabilitiesAssumed" xlink:label="BusinessAcquisitionPurchasePriceAllocationLiabilitiesAssumed" xlink:title="BusinessAcquisitionPurchasePriceAllocationLiabilitiesAssumed"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionPurchasePriceAllocationLiabilitiesAssumed" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionPurchasePriceAllocationLiabilitiesAssumed" order="18.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionContingentConsiderationAtFairValue" xlink:label="BusinessAcquisitionContingentConsiderationAtFairValue" xlink:title="BusinessAcquisitionContingentConsiderationAtFairValue"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionContingentConsiderationAtFairValue" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionContingentConsiderationAtFairValue" order="19.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationAssetsAcquiredLiabilitiesAssumedNet" xlink:label="BusinessAcquisitionPurchasePriceAllocationAssetsAcquiredLiabilitiesAssumedNet" xlink:title="BusinessAcquisitionPurchasePriceAllocationAssetsAcquiredLiabilitiesAssumedNet"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionPurchasePriceAllocationAssetsAcquiredLiabilitiesAssumedNet" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionPurchasePriceAllocationAssetsAcquiredLiabilitiesAssumedNet" order="20.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_BusinessAcquisitionAssetsPurchasedAbstract" xlink:label="BusinessAcquisitionAssetsPurchasedAbstract" xlink:title="BusinessAcquisitionAssetsPurchasedAbstract"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionAssetsPurchasedAbstract" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionAssetsPurchasedAbstract" order="21.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationTangibleAssetsAbstract" xlink:label="BusinessAcquisitionPurchasePriceAllocationTangibleAssetsAbstract" xlink:title="BusinessAcquisitionPurchasePriceAllocationTangibleAssetsAbstract"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionPurchasePriceAllocationTangibleAssetsAbstract" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionPurchasePriceAllocationTangibleAssetsAbstract" order="22.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems" xlink:label="AcquiredFiniteLivedIntangibleAssetsLineItems" xlink:title="AcquiredFiniteLivedIntangibleAssetsLineItems"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="AcquiredFiniteLivedIntangibleAssetsLineItems" xlink:title="definition: BusinessAcquisitionLineItems to AcquiredFiniteLivedIntangibleAssetsLineItems" order="23.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AcquiredIndefiniteLivedIntangibleAssetsLineItems" xlink:label="AcquiredIndefiniteLivedIntangibleAssetsLineItems" xlink:title="AcquiredIndefiniteLivedIntangibleAssetsLineItems"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="AcquiredIndefiniteLivedIntangibleAssetsLineItems" xlink:title="definition: BusinessAcquisitionLineItems to AcquiredIndefiniteLivedIntangibleAssetsLineItems" order="24.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill" xlink:label="BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill" xlink:title="BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill" order="25.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationGoodwillAmount" xlink:label="BusinessAcquisitionPurchasePriceAllocationGoodwillAmount" xlink:title="BusinessAcquisitionPurchasePriceAllocationGoodwillAmount"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionPurchasePriceAllocationGoodwillAmount" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionPurchasePriceAllocationGoodwillAmount" order="26.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:label="BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:title="BusinessAcquisitionCostOfAcquiredEntityPurchasePrice"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" order="27.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_BusinessAcquisitionPurchasePriceAllocationWorkingCapitalAndOtherAssetsAbstract" xlink:label="BusinessAcquisitionPurchasePriceAllocationWorkingCapitalAndOtherAssetsAbstract" xlink:title="BusinessAcquisitionPurchasePriceAllocationWorkingCapitalAndOtherAssetsAbstract"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionPurchasePriceAllocationWorkingCapitalAndOtherAssetsAbstract" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionPurchasePriceAllocationWorkingCapitalAndOtherAssetsAbstract" order="28.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_BusinessAcquisitionPurchasePriceAllocationWorkingCapitalAbstract" xlink:label="BusinessAcquisitionPurchasePriceAllocationWorkingCapitalAbstract" xlink:title="BusinessAcquisitionPurchasePriceAllocationWorkingCapitalAbstract"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionPurchasePriceAllocationWorkingCapitalAbstract" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionPurchasePriceAllocationWorkingCapitalAbstract" order="29.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssetsCashAndCashEquivalents" xlink:label="BusinessAcquisitionPurchasePriceAllocationCurrentAssetsCashAndCashEquivalents" xlink:title="BusinessAcquisitionPurchasePriceAllocationCurrentAssetsCashAndCashEquivalents"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionPurchasePriceAllocationCurrentAssetsCashAndCashEquivalents" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionPurchasePriceAllocationCurrentAssetsCashAndCashEquivalents" order="30.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssetsPrepaidExpenseAndOtherAssets" xlink:label="BusinessAcquisitionPurchasePriceAllocationCurrentAssetsPrepaidExpenseAndOtherAssets" xlink:title="BusinessAcquisitionPurchasePriceAllocationCurrentAssetsPrepaidExpenseAndOtherAssets"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionPurchasePriceAllocationCurrentAssetsPrepaidExpenseAndOtherAssets" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionPurchasePriceAllocationCurrentAssetsPrepaidExpenseAndOtherAssets" order="31.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssetsReceivables" xlink:label="BusinessAcquisitionPurchasePriceAllocationCurrentAssetsReceivables" xlink:title="BusinessAcquisitionPurchasePriceAllocationCurrentAssetsReceivables"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionPurchasePriceAllocationCurrentAssetsReceivables" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionPurchasePriceAllocationCurrentAssetsReceivables" order="32.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_BusinessAcquisitionPurchasePriceAllocationLicenseReceivable" xlink:label="BusinessAcquisitionPurchasePriceAllocationLicenseReceivable" xlink:title="BusinessAcquisitionPurchasePriceAllocationLicenseReceivable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionPurchasePriceAllocationLicenseReceivable" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionPurchasePriceAllocationLicenseReceivable" order="33.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssetsInventory" xlink:label="BusinessAcquisitionPurchasePriceAllocationCurrentAssetsInventory" xlink:title="BusinessAcquisitionPurchasePriceAllocationCurrentAssetsInventory"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionPurchasePriceAllocationCurrentAssetsInventory" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionPurchasePriceAllocationCurrentAssetsInventory" order="34.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayable" xlink:label="BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayable" xlink:title="BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayable" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayable" order="35.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesDeferredRevenue" xlink:label="BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesDeferredRevenue" xlink:title="BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesDeferredRevenue"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesDeferredRevenue" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesDeferredRevenue" order="36.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_BusinessAcquisitionPurchasePriceAllocationDebt-FreeWorkingCapital" xlink:label="BusinessAcquisitionPurchasePriceAllocationDebt-FreeWorkingCapital" xlink:title="BusinessAcquisitionPurchasePriceAllocationDebt-FreeWorkingCapital"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionPurchasePriceAllocationDebt-FreeWorkingCapital" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionPurchasePriceAllocationDebt-FreeWorkingCapital" order="37.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesLongTermDebt" xlink:label="BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesLongTermDebt" xlink:title="BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesLongTermDebt"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesLongTermDebt" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesLongTermDebt" order="38.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationNoncurrentLiabilitiesLongTermDebt" xlink:label="BusinessAcquisitionPurchasePriceAllocationNoncurrentLiabilitiesLongTermDebt" xlink:title="BusinessAcquisitionPurchasePriceAllocationNoncurrentLiabilitiesLongTermDebt"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionPurchasePriceAllocationNoncurrentLiabilitiesLongTermDebt" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionPurchasePriceAllocationNoncurrentLiabilitiesLongTermDebt" order="39.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_BusinessAcquisitionPurchasePriceAllocationLineOfCredit" xlink:label="BusinessAcquisitionPurchasePriceAllocationLineOfCredit" xlink:title="BusinessAcquisitionPurchasePriceAllocationLineOfCredit"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="BusinessAcquisitionLineItems" xlink:to="BusinessAcquisitionPurchasePriceAllocationLineOfCredit" xlink:title="definition: BusinessAcquisitionLineItems to BusinessAcquisitionPurchasePriceAllocationLineOfCredit" order="40.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_NetWorkingCapital" xlink:label="NetWorkingCapital" xlink:title="NetWorkingCapital"/>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PatentsMember" xlink:label="PatentsMember" xlink:title="PatentsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:to="PatentsMember" xlink:title="definition: FiniteLivedIntangibleAssetsMajorClassNameDomain to PatentsMember" order="3.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LicensingAgreementsMember" xlink:label="LicensingAgreementsMember" xlink:title="LicensingAgreementsMember"/>
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<link:definitionLink xlink:type="extended" xlink:role="http://mimedx.com/role/InventoriesDetails"/>
<link:definitionLink xlink:type="extended" xlink:role="http://mimedx.com/role/PropertyAndEquipmentDetails">
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross" xlink:label="PropertyPlantAndEquipmentGross" xlink:title="PropertyPlantAndEquipmentGross"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="PropertyPlantAndEquipmentLineItems" xlink:to="PropertyPlantAndEquipmentGross" xlink:title="definition: PropertyPlantAndEquipmentLineItems to PropertyPlantAndEquipmentGross" order="1.0"/>
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="PropertyPlantAndEquipmentLineItems" xlink:to="AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:title="definition: PropertyPlantAndEquipmentLineItems to AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" order="2.0"/>
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="PropertyPlantAndEquipmentLineItems" xlink:to="ScheduleOfPropertyPlantAndEquipmentTable" xlink:title="definition: PropertyPlantAndEquipmentLineItems to ScheduleOfPropertyPlantAndEquipmentTable" order="4.0" t1:contextElement="segment"/>
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ScheduleOfPropertyPlantAndEquipmentTable" xlink:to="PropertyPlantAndEquipmentByTypeAxis" xlink:title="definition: ScheduleOfPropertyPlantAndEquipmentTable to PropertyPlantAndEquipmentByTypeAxis" order="1.0"/>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="PropertyPlantAndEquipmentTypeDomain_2" xlink:title="PropertyPlantAndEquipmentTypeDomain"/>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LeaseholdImprovementsMember" xlink:label="LeaseholdImprovementsMember" xlink:title="LeaseholdImprovementsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="PropertyPlantAndEquipmentTypeDomain" xlink:to="LeaseholdImprovementsMember" xlink:title="definition: PropertyPlantAndEquipmentTypeDomain to LeaseholdImprovementsMember" order="1.0"/>
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="PropertyPlantAndEquipmentTypeDomain" xlink:to="EquipmentMember" xlink:title="definition: PropertyPlantAndEquipmentTypeDomain to EquipmentMember" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FurnitureAndFixturesMember" xlink:label="FurnitureAndFixturesMember" xlink:title="FurnitureAndFixturesMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="PropertyPlantAndEquipmentTypeDomain" xlink:to="FurnitureAndFixturesMember" xlink:title="definition: PropertyPlantAndEquipmentTypeDomain to FurnitureAndFixturesMember" order="3.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ConstructionInProgressMember" xlink:label="ConstructionInProgressMember" xlink:title="ConstructionInProgressMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="PropertyPlantAndEquipmentTypeDomain" xlink:to="ConstructionInProgressMember" xlink:title="definition: PropertyPlantAndEquipmentTypeDomain to ConstructionInProgressMember" order="4.0"/>
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="IndefiniteLivedIntangibleAssetsByMajorClassLineItems" xlink:to="WeightedAverageUsefulLifeIndefiniteLived" xlink:title="definition: IndefiniteLivedIntangibleAssetsByMajorClassLineItems to WeightedAverageUsefulLifeIndefiniteLived" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill" xlink:label="IndefiniteLivedIntangibleAssetsExcludingGoodwill" xlink:title="IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="IndefiniteLivedIntangibleAssetsByMajorClassLineItems" xlink:to="IndefiniteLivedIntangibleAssetsExcludingGoodwill" xlink:title="definition: IndefiniteLivedIntangibleAssetsByMajorClassLineItems to IndefiniteLivedIntangibleAssetsExcludingGoodwill" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_IntangibleAssetsImpairmentAdjustment" xlink:label="IntangibleAssetsImpairmentAdjustment" xlink:title="IntangibleAssetsImpairmentAdjustment"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="IndefiniteLivedIntangibleAssetsByMajorClassLineItems" xlink:to="IntangibleAssetsImpairmentAdjustment" xlink:title="definition: IndefiniteLivedIntangibleAssetsByMajorClassLineItems to IntangibleAssetsImpairmentAdjustment" order="3.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_IntangibleAssetsAccumulatedAmortization" xlink:label="IntangibleAssetsAccumulatedAmortization" xlink:title="IntangibleAssetsAccumulatedAmortization"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="IndefiniteLivedIntangibleAssetsByMajorClassLineItems" xlink:to="IntangibleAssetsAccumulatedAmortization" xlink:title="definition: IndefiniteLivedIntangibleAssetsByMajorClassLineItems to IntangibleAssetsAccumulatedAmortization" order="4.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfIndefiniteLivedIntangibleAssetsTable" xlink:label="ScheduleOfIndefiniteLivedIntangibleAssetsTable" xlink:title="ScheduleOfIndefiniteLivedIntangibleAssetsTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="IndefiniteLivedIntangibleAssetsByMajorClassLineItems" xlink:to="ScheduleOfIndefiniteLivedIntangibleAssetsTable" xlink:title="definition: IndefiniteLivedIntangibleAssetsByMajorClassLineItems to ScheduleOfIndefiniteLivedIntangibleAssetsTable" order="5.0" t1:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="IndefiniteLivedIntangibleAssetsByMajorClassAxis" xlink:title="IndefiniteLivedIntangibleAssetsByMajorClassAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ScheduleOfIndefiniteLivedIntangibleAssetsTable" xlink:to="IndefiniteLivedIntangibleAssetsByMajorClassAxis" xlink:title="definition: ScheduleOfIndefiniteLivedIntangibleAssetsTable to IndefiniteLivedIntangibleAssetsByMajorClassAxis" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="IndefiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:title="IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="IndefiniteLivedIntangibleAssetsByMajorClassAxis" xlink:to="IndefiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:title="definition: IndefiniteLivedIntangibleAssetsByMajorClassAxis to IndefiniteLivedIntangibleAssetsMajorClassNameDomain" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="IndefiniteLivedIntangibleAssetsMajorClassNameDomain_2" xlink:title="IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="IndefiniteLivedIntangibleAssetsByMajorClassAxis" xlink:to="IndefiniteLivedIntangibleAssetsMajorClassNameDomain_2" xlink:title="definition: IndefiniteLivedIntangibleAssetsByMajorClassAxis to IndefiniteLivedIntangibleAssetsMajorClassNameDomain_2" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_TradeNamesAndTrademarksMember" xlink:label="TradeNamesAndTrademarksMember" xlink:title="TradeNamesAndTrademarksMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="IndefiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:to="TradeNamesAndTrademarksMember" xlink:title="definition: IndefiniteLivedIntangibleAssetsMajorClassNameDomain to TradeNamesAndTrademarksMember" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_InProcessResearchAndDevelopmentLiquidMember" xlink:label="InProcessResearchAndDevelopmentLiquidMember" xlink:title="InProcessResearchAndDevelopmentLiquidMember"/>
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<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_InProcessResearchAndDevelopmentOtherMember" xlink:label="InProcessResearchAndDevelopmentOtherMember" xlink:title="InProcessResearchAndDevelopmentOtherMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="IndefiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:to="InProcessResearchAndDevelopmentOtherMember" xlink:title="definition: IndefiniteLivedIntangibleAssetsMajorClassNameDomain to InProcessResearchAndDevelopmentOtherMember" order="3.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems" xlink:label="FiniteLivedIntangibleAssetsLineItems" xlink:title="FiniteLivedIntangibleAssetsLineItems"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife" xlink:label="AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife" xlink:title="AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="FiniteLivedIntangibleAssetsLineItems" xlink:to="AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife" xlink:title="definition: FiniteLivedIntangibleAssetsLineItems to AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross" xlink:label="FiniteLivedIntangibleAssetsGross" xlink:title="FiniteLivedIntangibleAssetsGross"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="FiniteLivedIntangibleAssetsLineItems" xlink:to="FiniteLivedIntangibleAssetsGross" xlink:title="definition: FiniteLivedIntangibleAssetsLineItems to FiniteLivedIntangibleAssetsGross" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_Finite-LivedIntangibleAssetsImpairmentAdjustment" xlink:label="Finite-LivedIntangibleAssetsImpairmentAdjustment" xlink:title="Finite-LivedIntangibleAssetsImpairmentAdjustment"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="FiniteLivedIntangibleAssetsLineItems" xlink:to="Finite-LivedIntangibleAssetsImpairmentAdjustment" xlink:title="definition: FiniteLivedIntangibleAssetsLineItems to Finite-LivedIntangibleAssetsImpairmentAdjustment" order="3.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization" xlink:label="FiniteLivedIntangibleAssetsAccumulatedAmortization" xlink:title="FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="FiniteLivedIntangibleAssetsLineItems" xlink:to="FiniteLivedIntangibleAssetsAccumulatedAmortization" xlink:title="definition: FiniteLivedIntangibleAssetsLineItems to FiniteLivedIntangibleAssetsAccumulatedAmortization" order="4.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet" xlink:label="FiniteLivedIntangibleAssetsNet" xlink:title="FiniteLivedIntangibleAssetsNet"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="FiniteLivedIntangibleAssetsLineItems" xlink:to="FiniteLivedIntangibleAssetsNet" xlink:title="definition: FiniteLivedIntangibleAssetsLineItems to FiniteLivedIntangibleAssetsNet" order="5.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PaymentsToAcquireIntangibleAssets" xlink:label="PaymentsToAcquireIntangibleAssets" xlink:title="PaymentsToAcquireIntangibleAssets"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="FiniteLivedIntangibleAssetsLineItems" xlink:to="PaymentsToAcquireIntangibleAssets" xlink:title="definition: FiniteLivedIntangibleAssetsLineItems to PaymentsToAcquireIntangibleAssets" order="6.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesIssuedForServices" xlink:label="StockIssuedDuringPeriodSharesIssuedForServices" xlink:title="StockIssuedDuringPeriodSharesIssuedForServices"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="FiniteLivedIntangibleAssetsLineItems" xlink:to="StockIssuedDuringPeriodSharesIssuedForServices" xlink:title="definition: FiniteLivedIntangibleAssetsLineItems to StockIssuedDuringPeriodSharesIssuedForServices" order="7.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueIssuedForServices" xlink:label="StockIssuedDuringPeriodValueIssuedForServices" xlink:title="StockIssuedDuringPeriodValueIssuedForServices"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="FiniteLivedIntangibleAssetsLineItems" xlink:to="StockIssuedDuringPeriodValueIssuedForServices" xlink:title="definition: FiniteLivedIntangibleAssetsLineItems to StockIssuedDuringPeriodValueIssuedForServices" order="8.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_PeriodOfApprovalMaximum" xlink:label="PeriodOfApprovalMaximum" xlink:title="PeriodOfApprovalMaximum"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="FiniteLivedIntangibleAssetsLineItems" xlink:to="PeriodOfApprovalMaximum" xlink:title="definition: FiniteLivedIntangibleAssetsLineItems to PeriodOfApprovalMaximum" order="9.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionContingentConsiderationPotentialCashPayment" xlink:label="BusinessAcquisitionContingentConsiderationPotentialCashPayment" xlink:title="BusinessAcquisitionContingentConsiderationPotentialCashPayment"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="FiniteLivedIntangibleAssetsLineItems" xlink:to="BusinessAcquisitionContingentConsiderationPotentialCashPayment" xlink:title="definition: FiniteLivedIntangibleAssetsLineItems to BusinessAcquisitionContingentConsiderationPotentialCashPayment" order="10.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_ContingentRoyaltyToBePaidToLicensor" xlink:label="ContingentRoyaltyToBePaidToLicensor" xlink:title="ContingentRoyaltyToBePaidToLicensor"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="FiniteLivedIntangibleAssetsLineItems" xlink:to="ContingentRoyaltyToBePaidToLicensor" xlink:title="definition: FiniteLivedIntangibleAssetsLineItems to ContingentRoyaltyToBePaidToLicensor" order="11.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RoyaltyExpense" xlink:label="RoyaltyExpense" xlink:title="RoyaltyExpense"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="FiniteLivedIntangibleAssetsLineItems" xlink:to="RoyaltyExpense" xlink:title="definition: FiniteLivedIntangibleAssetsLineItems to RoyaltyExpense" order="12.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_StockIssuedDuringPeriodSharesIssuedForPurchaseOfSurgicalSheets" xlink:label="StockIssuedDuringPeriodSharesIssuedForPurchaseOfSurgicalSheets" xlink:title="StockIssuedDuringPeriodSharesIssuedForPurchaseOfSurgicalSheets"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="FiniteLivedIntangibleAssetsLineItems" xlink:to="StockIssuedDuringPeriodSharesIssuedForPurchaseOfSurgicalSheets" xlink:title="definition: FiniteLivedIntangibleAssetsLineItems to StockIssuedDuringPeriodSharesIssuedForPurchaseOfSurgicalSheets" order="13.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_StockIssuedDuringPeriodValueIssuedForPurchaseOfSurgicalSheets" xlink:label="StockIssuedDuringPeriodValueIssuedForPurchaseOfSurgicalSheets" xlink:title="StockIssuedDuringPeriodValueIssuedForPurchaseOfSurgicalSheets"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="FiniteLivedIntangibleAssetsLineItems" xlink:to="StockIssuedDuringPeriodValueIssuedForPurchaseOfSurgicalSheets" xlink:title="definition: FiniteLivedIntangibleAssetsLineItems to StockIssuedDuringPeriodValueIssuedForPurchaseOfSurgicalSheets" order="14.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionContingentConsiderationSharesIssuable" xlink:label="BusinessAcquisitionContingentConsiderationSharesIssuable" xlink:title="BusinessAcquisitionContingentConsiderationSharesIssuable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="FiniteLivedIntangibleAssetsLineItems" xlink:to="BusinessAcquisitionContingentConsiderationSharesIssuable" xlink:title="definition: FiniteLivedIntangibleAssetsLineItems to BusinessAcquisitionContingentConsiderationSharesIssuable" order="15.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_ContingentPaymentsToLicensorSharesIssued" xlink:label="ContingentPaymentsToLicensorSharesIssued" xlink:title="ContingentPaymentsToLicensorSharesIssued"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="FiniteLivedIntangibleAssetsLineItems" xlink:to="ContingentPaymentsToLicensorSharesIssued" xlink:title="definition: FiniteLivedIntangibleAssetsLineItems to ContingentPaymentsToLicensorSharesIssued" order="16.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_MilestoneStockIssuedDuringPeriodValue" xlink:label="MilestoneStockIssuedDuringPeriodValue" xlink:title="MilestoneStockIssuedDuringPeriodValue"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="FiniteLivedIntangibleAssetsLineItems" xlink:to="MilestoneStockIssuedDuringPeriodValue" xlink:title="definition: FiniteLivedIntangibleAssetsLineItems to MilestoneStockIssuedDuringPeriodValue" order="17.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable" xlink:label="ScheduleOfFiniteLivedIntangibleAssetsTable" xlink:title="ScheduleOfFiniteLivedIntangibleAssetsTable"/>
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<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_License-SalumedicaLlcSpineRepairMember" xlink:label="License-SalumedicaLlcSpineRepairMember" xlink:title="License-SalumedicaLlcSpineRepairMember"/>
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<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_License-PolyvinylAlcoholCryogelMember" xlink:label="License-PolyvinylAlcoholCryogelMember" xlink:title="License-PolyvinylAlcoholCryogelMember"/>
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<link:definitionLink xlink:type="extended" xlink:role="http://mimedx.com/role/AccruedExpensesDetails"/>
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<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_LongTermDebtIncludingRelatedPartyExcludingCurrentMaturities" xlink:label="LongTermDebtIncludingRelatedPartyExcludingCurrentMaturities" xlink:title="LongTermDebtIncludingRelatedPartyExcludingCurrentMaturities"/>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LongTermDebtNoncurrent" xlink:label="LongTermDebtNoncurrent" xlink:title="LongTermDebtNoncurrent"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="DebtInstrumentLineItems" xlink:to="LongTermDebtNoncurrent" xlink:title="definition: DebtInstrumentLineItems to LongTermDebtNoncurrent" order="4.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="DebtInstrumentInterestRateStatedPercentage" xlink:title="DebtInstrumentInterestRateStatedPercentage"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="DebtInstrumentLineItems" xlink:to="DebtInstrumentInterestRateStatedPercentage" xlink:title="definition: DebtInstrumentLineItems to DebtInstrumentInterestRateStatedPercentage" order="5.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtInstrumentMaturityDate" xlink:label="DebtInstrumentMaturityDate" xlink:title="DebtInstrumentMaturityDate"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="DebtInstrumentLineItems" xlink:to="DebtInstrumentMaturityDate" xlink:title="definition: DebtInstrumentLineItems to DebtInstrumentMaturityDate" order="6.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_AdditionalInterestPaymentPercentage" xlink:label="AdditionalInterestPaymentPercentage" xlink:title="AdditionalInterestPaymentPercentage"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="DebtInstrumentLineItems" xlink:to="AdditionalInterestPaymentPercentage" xlink:title="definition: DebtInstrumentLineItems to AdditionalInterestPaymentPercentage" order="7.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities" xlink:label="StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities" xlink:title="StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="DebtInstrumentLineItems" xlink:to="StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities" xlink:title="definition: DebtInstrumentLineItems to StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities" order="8.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RepaymentsOfConvertibleDebt" xlink:label="RepaymentsOfConvertibleDebt" xlink:title="RepaymentsOfConvertibleDebt"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="DebtInstrumentLineItems" xlink:to="RepaymentsOfConvertibleDebt" xlink:title="definition: DebtInstrumentLineItems to RepaymentsOfConvertibleDebt" order="9.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_PercentageOfEquitySecuritiesToBeSoldForConversionOfNotes" xlink:label="PercentageOfEquitySecuritiesToBeSoldForConversionOfNotes" xlink:title="PercentageOfEquitySecuritiesToBeSoldForConversionOfNotes"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="DebtInstrumentLineItems" xlink:to="PercentageOfEquitySecuritiesToBeSoldForConversionOfNotes" xlink:title="definition: DebtInstrumentLineItems to PercentageOfEquitySecuritiesToBeSoldForConversionOfNotes" order="10.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_WarrantExercisePrice" xlink:label="WarrantExercisePrice" xlink:title="WarrantExercisePrice"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="DebtInstrumentLineItems" xlink:to="WarrantExercisePrice" xlink:title="definition: DebtInstrumentLineItems to WarrantExercisePrice" order="11.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_WarrantsVested" xlink:label="WarrantsVested" xlink:title="WarrantsVested"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="DebtInstrumentLineItems" xlink:to="WarrantsVested" xlink:title="definition: DebtInstrumentLineItems to WarrantsVested" order="12.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_WarrantsVoided" xlink:label="WarrantsVoided" xlink:title="WarrantsVoided"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="DebtInstrumentLineItems" xlink:to="WarrantsVoided" xlink:title="definition: DebtInstrumentLineItems to WarrantsVoided" order="13.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_ClosingTradingPriceOfCompanyStock" xlink:label="ClosingTradingPriceOfCompanyStock" xlink:title="ClosingTradingPriceOfCompanyStock"/>
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<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_NumberOfConsecutiveTradingDays" xlink:label="NumberOfConsecutiveTradingDays" xlink:title="NumberOfConsecutiveTradingDays"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="DebtInstrumentLineItems" xlink:to="NumberOfConsecutiveTradingDays" xlink:title="definition: DebtInstrumentLineItems to NumberOfConsecutiveTradingDays" order="15.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_BeneficialConversionFeatureValueRelatedToConvertibleDebtIssuedWithRegardToSeniorSecuredPromissoryNotes" xlink:label="BeneficialConversionFeatureValueRelatedToConvertibleDebtIssuedWithRegardToSeniorSecuredPromissoryNotes" xlink:title="BeneficialConversionFeatureValueRelatedToConvertibleDebtIssuedWithRegardToSeniorSecuredPromissoryNotes"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="DebtInstrumentLineItems" xlink:to="BeneficialConversionFeatureValueRelatedToConvertibleDebtIssuedWithRegardToSeniorSecuredPromissoryNotes" xlink:title="definition: DebtInstrumentLineItems to BeneficialConversionFeatureValueRelatedToConvertibleDebtIssuedWithRegardToSeniorSecuredPromissoryNotes" order="16.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredFinanceCostsGross" xlink:label="DeferredFinanceCostsGross" xlink:title="DeferredFinanceCostsGross"/>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ProceedsFromIssuanceOfDebt" xlink:label="ProceedsFromIssuanceOfDebt" xlink:title="ProceedsFromIssuanceOfDebt"/>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtInstrumentConvertibleNumberOfEquityInstruments" xlink:label="DebtInstrumentConvertibleNumberOfEquityInstruments" xlink:title="DebtInstrumentConvertibleNumberOfEquityInstruments"/>
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<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_PlacementFee" xlink:label="PlacementFee" xlink:title="PlacementFee"/>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_WarrantsNotSettleableInCashFairValueDisclosure" xlink:label="WarrantsNotSettleableInCashFairValueDisclosure" xlink:title="WarrantsNotSettleableInCashFairValueDisclosure"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="DebtInstrumentLineItems" xlink:to="WarrantsNotSettleableInCashFairValueDisclosure" xlink:title="definition: DebtInstrumentLineItems to WarrantsNotSettleableInCashFairValueDisclosure" order="23.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtIssuanceCosts" xlink:label="DebtIssuanceCosts" xlink:title="DebtIssuanceCosts"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="DebtInstrumentLineItems" xlink:to="DebtIssuanceCosts" xlink:title="definition: DebtInstrumentLineItems to DebtIssuanceCosts" order="24.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtConversionConvertedInstrumentSharesIssued1" xlink:label="DebtConversionConvertedInstrumentSharesIssued1" xlink:title="DebtConversionConvertedInstrumentSharesIssued1"/>
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<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="DebtInstrumentTable" xlink:title="DebtInstrumentTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="DebtInstrumentLineItems" xlink:to="DebtInstrumentTable" xlink:title="definition: DebtInstrumentLineItems to DebtInstrumentTable" order="26.0" t1:contextElement="segment"/>
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="DebtInstrumentAxis" xlink:to="DebtInstrumentNameDomain" xlink:title="definition: DebtInstrumentAxis to DebtInstrumentNameDomain" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="DebtInstrumentNameDomain_2" xlink:title="DebtInstrumentNameDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="DebtInstrumentAxis" xlink:to="DebtInstrumentNameDomain_2" xlink:title="definition: DebtInstrumentAxis to DebtInstrumentNameDomain_2" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ConvertibleDebtMember" xlink:label="ConvertibleDebtMember" xlink:title="ConvertibleDebtMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="DebtInstrumentNameDomain" xlink:to="ConvertibleDebtMember" xlink:title="definition: DebtInstrumentNameDomain to ConvertibleDebtMember" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_FivePercentConvertibleSeniorSecuredPromissoryNoteMember" xlink:label="FivePercentConvertibleSeniorSecuredPromissoryNoteMember" xlink:title="FivePercentConvertibleSeniorSecuredPromissoryNoteMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="DebtInstrumentNameDomain" xlink:to="FivePercentConvertibleSeniorSecuredPromissoryNoteMember" xlink:title="definition: DebtInstrumentNameDomain to FivePercentConvertibleSeniorSecuredPromissoryNoteMember" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LineOfCreditFacilityAxis" xlink:label="LineOfCreditFacilityAxis" xlink:title="LineOfCreditFacilityAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="DebtInstrumentTable" xlink:to="LineOfCreditFacilityAxis" xlink:title="definition: DebtInstrumentTable to LineOfCreditFacilityAxis" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LineOfCreditFacilityLenderDomain" xlink:label="LineOfCreditFacilityLenderDomain" xlink:title="LineOfCreditFacilityLenderDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="LineOfCreditFacilityAxis" xlink:to="LineOfCreditFacilityLenderDomain" xlink:title="definition: LineOfCreditFacilityAxis to LineOfCreditFacilityLenderDomain" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LineOfCreditFacilityLenderDomain" xlink:label="LineOfCreditFacilityLenderDomain_2" xlink:title="LineOfCreditFacilityLenderDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="LineOfCreditFacilityAxis" xlink:to="LineOfCreditFacilityLenderDomain_2" xlink:title="definition: LineOfCreditFacilityAxis to LineOfCreditFacilityLenderDomain_2" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BoardOfDirectorsChairmanMember" xlink:label="BoardOfDirectorsChairmanMember" xlink:title="BoardOfDirectorsChairmanMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="LineOfCreditFacilityLenderDomain" xlink:to="BoardOfDirectorsChairmanMember" xlink:title="definition: LineOfCreditFacilityLenderDomain to BoardOfDirectorsChairmanMember" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassOfWarrantOrRightAxis" xlink:label="ClassOfWarrantOrRightAxis" xlink:title="ClassOfWarrantOrRightAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="DebtInstrumentTable" xlink:to="ClassOfWarrantOrRightAxis" xlink:title="definition: DebtInstrumentTable to ClassOfWarrantOrRightAxis" order="3.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="ClassOfWarrantOrRightDomain" xlink:title="ClassOfWarrantOrRightDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="ClassOfWarrantOrRightAxis" xlink:to="ClassOfWarrantOrRightDomain" xlink:title="definition: ClassOfWarrantOrRightAxis to ClassOfWarrantOrRightDomain" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="ClassOfWarrantOrRightDomain_2" xlink:title="ClassOfWarrantOrRightDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="ClassOfWarrantOrRightAxis" xlink:to="ClassOfWarrantOrRightDomain_2" xlink:title="definition: ClassOfWarrantOrRightAxis to ClassOfWarrantOrRightDomain_2" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_FirstContingentWarrantsMember" xlink:label="FirstContingentWarrantsMember" xlink:title="FirstContingentWarrantsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ClassOfWarrantOrRightDomain" xlink:to="FirstContingentWarrantsMember" xlink:title="definition: ClassOfWarrantOrRightDomain to FirstContingentWarrantsMember" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_SecondContingentWarrantsMember" xlink:label="SecondContingentWarrantsMember" xlink:title="SecondContingentWarrantsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ClassOfWarrantOrRightDomain" xlink:to="SecondContingentWarrantsMember" xlink:title="definition: ClassOfWarrantOrRightDomain to SecondContingentWarrantsMember" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CreditFacilityAxis" xlink:label="CreditFacilityAxis" xlink:title="CreditFacilityAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="DebtInstrumentTable" xlink:to="CreditFacilityAxis" xlink:title="definition: DebtInstrumentTable to CreditFacilityAxis" order="4.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CreditFacilityDomain" xlink:label="CreditFacilityDomain" xlink:title="CreditFacilityDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="CreditFacilityAxis" xlink:to="CreditFacilityDomain" xlink:title="definition: CreditFacilityAxis to CreditFacilityDomain" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CreditFacilityDomain" xlink:label="CreditFacilityDomain_2" xlink:title="CreditFacilityDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="CreditFacilityAxis" xlink:to="CreditFacilityDomain_2" xlink:title="definition: CreditFacilityAxis to CreditFacilityDomain_2" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RevolvingCreditFacilityMember" xlink:label="RevolvingCreditFacilityMember" xlink:title="RevolvingCreditFacilityMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="CreditFacilityDomain" xlink:to="RevolvingCreditFacilityMember" xlink:title="definition: CreditFacilityDomain to RevolvingCreditFacilityMember" order="1.0"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://mimedx.com/role/CommonStockPlacementsDetails">
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_SaleOfStocksAndWarrantsLineItems" xlink:label="SaleOfStocksAndWarrantsLineItems" xlink:title="SaleOfStocksAndWarrantsLineItems"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="StockIssuedDuringPeriodSharesNewIssues" xlink:title="StockIssuedDuringPeriodSharesNewIssues"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SaleOfStocksAndWarrantsLineItems" xlink:to="StockIssuedDuringPeriodSharesNewIssues" xlink:title="definition: SaleOfStocksAndWarrantsLineItems to StockIssuedDuringPeriodSharesNewIssues" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_WarrantsVoided" xlink:label="WarrantsVoided" xlink:title="WarrantsVoided"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SaleOfStocksAndWarrantsLineItems" xlink:to="WarrantsVoided" xlink:title="definition: SaleOfStocksAndWarrantsLineItems to WarrantsVoided" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SharePrice" xlink:label="SharePrice" xlink:title="SharePrice"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SaleOfStocksAndWarrantsLineItems" xlink:to="SharePrice" xlink:title="definition: SaleOfStocksAndWarrantsLineItems to SharePrice" order="3.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_PrivatePlacementOfferingCosts" xlink:label="PrivatePlacementOfferingCosts" xlink:title="PrivatePlacementOfferingCosts"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SaleOfStocksAndWarrantsLineItems" xlink:to="PrivatePlacementOfferingCosts" xlink:title="definition: SaleOfStocksAndWarrantsLineItems to PrivatePlacementOfferingCosts" order="4.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ProceedsFromIssuanceOfPrivatePlacement" xlink:label="ProceedsFromIssuanceOfPrivatePlacement" xlink:title="ProceedsFromIssuanceOfPrivatePlacement"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SaleOfStocksAndWarrantsLineItems" xlink:to="ProceedsFromIssuanceOfPrivatePlacement" xlink:title="definition: SaleOfStocksAndWarrantsLineItems to ProceedsFromIssuanceOfPrivatePlacement" order="5.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_WarrantsTerm" xlink:label="WarrantsTerm" xlink:title="WarrantsTerm"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SaleOfStocksAndWarrantsLineItems" xlink:to="WarrantsTerm" xlink:title="definition: SaleOfStocksAndWarrantsLineItems to WarrantsTerm" order="6.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_RedemptionPriceOfCallableWarrant" xlink:label="RedemptionPriceOfCallableWarrant" xlink:title="RedemptionPriceOfCallableWarrant"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SaleOfStocksAndWarrantsLineItems" xlink:to="RedemptionPriceOfCallableWarrant" xlink:title="definition: SaleOfStocksAndWarrantsLineItems to RedemptionPriceOfCallableWarrant" order="7.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_NumberOfSharesToBePurchasedToReceiveOneWarrant" xlink:label="NumberOfSharesToBePurchasedToReceiveOneWarrant" xlink:title="NumberOfSharesToBePurchasedToReceiveOneWarrant"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SaleOfStocksAndWarrantsLineItems" xlink:to="NumberOfSharesToBePurchasedToReceiveOneWarrant" xlink:title="definition: SaleOfStocksAndWarrantsLineItems to NumberOfSharesToBePurchasedToReceiveOneWarrant" order="8.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_NumberOfSharesCoveredUnderEachWarrant" xlink:label="NumberOfSharesCoveredUnderEachWarrant" xlink:title="NumberOfSharesCoveredUnderEachWarrant"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SaleOfStocksAndWarrantsLineItems" xlink:to="NumberOfSharesCoveredUnderEachWarrant" xlink:title="definition: SaleOfStocksAndWarrantsLineItems to NumberOfSharesCoveredUnderEachWarrant" order="9.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_MinimumClosingPriceToExerciseCallableRights" xlink:label="MinimumClosingPriceToExerciseCallableRights" xlink:title="MinimumClosingPriceToExerciseCallableRights"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SaleOfStocksAndWarrantsLineItems" xlink:to="MinimumClosingPriceToExerciseCallableRights" xlink:title="definition: SaleOfStocksAndWarrantsLineItems to MinimumClosingPriceToExerciseCallableRights" order="10.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_MinimumNumberOfConsecutiveTradingDaysConsideredForClosingTradingPrice" xlink:label="MinimumNumberOfConsecutiveTradingDaysConsideredForClosingTradingPrice" xlink:title="MinimumNumberOfConsecutiveTradingDaysConsideredForClosingTradingPrice"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SaleOfStocksAndWarrantsLineItems" xlink:to="MinimumNumberOfConsecutiveTradingDaysConsideredForClosingTradingPrice" xlink:title="definition: SaleOfStocksAndWarrantsLineItems to MinimumNumberOfConsecutiveTradingDaysConsideredForClosingTradingPrice" order="11.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:label="ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:title="ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SaleOfStocksAndWarrantsLineItems" xlink:to="ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:title="definition: SaleOfStocksAndWarrantsLineItems to ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" order="12.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock" xlink:label="ProceedsFromIssuanceOfCommonStock" xlink:title="ProceedsFromIssuanceOfCommonStock"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SaleOfStocksAndWarrantsLineItems" xlink:to="ProceedsFromIssuanceOfCommonStock" xlink:title="definition: SaleOfStocksAndWarrantsLineItems to ProceedsFromIssuanceOfCommonStock" order="13.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="CommonStockSharesIssued" xlink:title="CommonStockSharesIssued"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SaleOfStocksAndWarrantsLineItems" xlink:to="CommonStockSharesIssued" xlink:title="definition: SaleOfStocksAndWarrantsLineItems to CommonStockSharesIssued" order="14.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_NumberOfWarrantsExercised" xlink:label="NumberOfWarrantsExercised" xlink:title="NumberOfWarrantsExercised"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SaleOfStocksAndWarrantsLineItems" xlink:to="NumberOfWarrantsExercised" xlink:title="definition: SaleOfStocksAndWarrantsLineItems to NumberOfWarrantsExercised" order="15.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_NumberOfCallableWarrantsRepurchased" xlink:label="NumberOfCallableWarrantsRepurchased" xlink:title="NumberOfCallableWarrantsRepurchased"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SaleOfStocksAndWarrantsLineItems" xlink:to="NumberOfCallableWarrantsRepurchased" xlink:title="definition: SaleOfStocksAndWarrantsLineItems to NumberOfCallableWarrantsRepurchased" order="16.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_PurchasePriceOfWarrantsRepurchased" xlink:label="PurchasePriceOfWarrantsRepurchased" xlink:title="PurchasePriceOfWarrantsRepurchased"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SaleOfStocksAndWarrantsLineItems" xlink:to="PurchasePriceOfWarrantsRepurchased" xlink:title="definition: SaleOfStocksAndWarrantsLineItems to PurchasePriceOfWarrantsRepurchased" order="17.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_NumberOfWarrantsVested" xlink:label="NumberOfWarrantsVested" xlink:title="NumberOfWarrantsVested"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SaleOfStocksAndWarrantsLineItems" xlink:to="NumberOfWarrantsVested" xlink:title="definition: SaleOfStocksAndWarrantsLineItems to NumberOfWarrantsVested" order="18.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_CommonStockAndWarrantsPrivatePlacementTable" xlink:label="CommonStockAndWarrantsPrivatePlacementTable" xlink:title="CommonStockAndWarrantsPrivatePlacementTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="SaleOfStocksAndWarrantsLineItems" xlink:to="CommonStockAndWarrantsPrivatePlacementTable" xlink:title="definition: SaleOfStocksAndWarrantsLineItems to CommonStockAndWarrantsPrivatePlacementTable" order="19.0" t1:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_SaleOfStockAndWarrantsEntityAxis" xlink:label="SaleOfStockAndWarrantsEntityAxis" xlink:title="SaleOfStockAndWarrantsEntityAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="CommonStockAndWarrantsPrivatePlacementTable" xlink:to="SaleOfStockAndWarrantsEntityAxis" xlink:title="definition: CommonStockAndWarrantsPrivatePlacementTable to SaleOfStockAndWarrantsEntityAxis" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_SaleOfStockAndWarrantsNameDomain" xlink:label="SaleOfStockAndWarrantsNameDomain" xlink:title="SaleOfStockAndWarrantsNameDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="SaleOfStockAndWarrantsEntityAxis" xlink:to="SaleOfStockAndWarrantsNameDomain" xlink:title="definition: SaleOfStockAndWarrantsEntityAxis to SaleOfStockAndWarrantsNameDomain" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_SaleOfStockAndWarrantsNameDomain" xlink:label="SaleOfStockAndWarrantsNameDomain_2" xlink:title="SaleOfStockAndWarrantsNameDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="SaleOfStockAndWarrantsEntityAxis" xlink:to="SaleOfStockAndWarrantsNameDomain_2" xlink:title="definition: SaleOfStockAndWarrantsEntityAxis to SaleOfStockAndWarrantsNameDomain_2" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BoardOfDirectorsChairmanMember" xlink:label="BoardOfDirectorsChairmanMember" xlink:title="BoardOfDirectorsChairmanMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SaleOfStockAndWarrantsNameDomain" xlink:to="BoardOfDirectorsChairmanMember" xlink:title="definition: SaleOfStockAndWarrantsNameDomain to BoardOfDirectorsChairmanMember" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="StatementEquityComponentsAxis" xlink:title="StatementEquityComponentsAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="CommonStockAndWarrantsPrivatePlacementTable" xlink:to="StatementEquityComponentsAxis" xlink:title="definition: CommonStockAndWarrantsPrivatePlacementTable to StatementEquityComponentsAxis" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="EquityComponentDomain" xlink:title="EquityComponentDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="StatementEquityComponentsAxis" xlink:to="EquityComponentDomain" xlink:title="definition: StatementEquityComponentsAxis to EquityComponentDomain" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="EquityComponentDomain_2" xlink:title="EquityComponentDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="StatementEquityComponentsAxis" xlink:to="EquityComponentDomain_2" xlink:title="definition: StatementEquityComponentsAxis to EquityComponentDomain_2" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CommonStockMember" xlink:label="CommonStockMember" xlink:title="CommonStockMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="EquityComponentDomain" xlink:to="CommonStockMember" xlink:title="definition: EquityComponentDomain to CommonStockMember" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_WarrantMember" xlink:label="WarrantMember" xlink:title="WarrantMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="EquityComponentDomain" xlink:to="WarrantMember" xlink:title="definition: EquityComponentDomain to WarrantMember" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_ContingentWarrantsMember" xlink:label="ContingentWarrantsMember" xlink:title="ContingentWarrantsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="EquityComponentDomain" xlink:to="ContingentWarrantsMember" xlink:title="definition: EquityComponentDomain to ContingentWarrantsMember" order="3.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_FirstContingentWarrantsMember" xlink:label="FirstContingentWarrantsMember" xlink:title="FirstContingentWarrantsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="EquityComponentDomain" xlink:to="FirstContingentWarrantsMember" xlink:title="definition: EquityComponentDomain to FirstContingentWarrantsMember" order="4.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_SecondContingentWarrantsMember" xlink:label="SecondContingentWarrantsMember" xlink:title="SecondContingentWarrantsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="EquityComponentDomain" xlink:to="SecondContingentWarrantsMember" xlink:title="definition: EquityComponentDomain to SecondContingentWarrantsMember" order="5.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SubsidiarySaleOfStockAxis" xlink:label="SubsidiarySaleOfStockAxis" xlink:title="SubsidiarySaleOfStockAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="CommonStockAndWarrantsPrivatePlacementTable" xlink:to="SubsidiarySaleOfStockAxis" xlink:title="definition: CommonStockAndWarrantsPrivatePlacementTable to SubsidiarySaleOfStockAxis" order="3.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain" xlink:label="SaleOfStockNameOfTransactionDomain" xlink:title="SaleOfStockNameOfTransactionDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="SubsidiarySaleOfStockAxis" xlink:to="SaleOfStockNameOfTransactionDomain" xlink:title="definition: SubsidiarySaleOfStockAxis to SaleOfStockNameOfTransactionDomain" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain" xlink:label="SaleOfStockNameOfTransactionDomain_2" xlink:title="SaleOfStockNameOfTransactionDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="SubsidiarySaleOfStockAxis" xlink:to="SaleOfStockNameOfTransactionDomain_2" xlink:title="definition: SubsidiarySaleOfStockAxis to SaleOfStockNameOfTransactionDomain_2" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_October2009PrivatePlacementMember" xlink:label="October2009PrivatePlacementMember" xlink:title="October2009PrivatePlacementMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SaleOfStockNameOfTransactionDomain" xlink:to="October2009PrivatePlacementMember" xlink:title="definition: SaleOfStockNameOfTransactionDomain to October2009PrivatePlacementMember" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_October2010PrivatePlacementMember" xlink:label="October2010PrivatePlacementMember" xlink:title="October2010PrivatePlacementMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SaleOfStockNameOfTransactionDomain" xlink:to="October2010PrivatePlacementMember" xlink:title="definition: SaleOfStockNameOfTransactionDomain to October2010PrivatePlacementMember" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_RepurchaseOfCallableWarrantsMember" xlink:label="RepurchaseOfCallableWarrantsMember" xlink:title="RepurchaseOfCallableWarrantsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SaleOfStockNameOfTransactionDomain" xlink:to="RepurchaseOfCallableWarrantsMember" xlink:title="definition: SaleOfStockNameOfTransactionDomain to RepurchaseOfCallableWarrantsMember" order="3.0"/>
</link:definitionLink>
<link:definitionLink xlink:type="extended" xlink:role="http://mimedx.com/role/EquityDetails">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassOfWarrantOrRightLineItems" xlink:label="ClassOfWarrantOrRightLineItems" xlink:title="ClassOfWarrantOrRightLineItems"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_WarrantsTerm" xlink:label="WarrantsTerm" xlink:title="WarrantsTerm"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ClassOfWarrantOrRightLineItems" xlink:to="WarrantsTerm" xlink:title="definition: ClassOfWarrantOrRightLineItems to WarrantsTerm" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_WarrantsNumberOfWarrantsRollForward" xlink:label="WarrantsNumberOfWarrantsRollForward" xlink:title="WarrantsNumberOfWarrantsRollForward"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ClassOfWarrantOrRightLineItems" xlink:to="WarrantsNumberOfWarrantsRollForward" xlink:title="definition: ClassOfWarrantOrRightLineItems to WarrantsNumberOfWarrantsRollForward" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_WarrantsWeighted-AverageExercisePricePerWarrantRollForward" xlink:label="WarrantsWeighted-AverageExercisePricePerWarrantRollForward" xlink:title="WarrantsWeighted-AverageExercisePricePerWarrantRollForward"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ClassOfWarrantOrRightLineItems" xlink:to="WarrantsWeighted-AverageExercisePricePerWarrantRollForward" xlink:title="definition: ClassOfWarrantOrRightLineItems to WarrantsWeighted-AverageExercisePricePerWarrantRollForward" order="3.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights" xlink:label="ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights" xlink:title="ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ClassOfWarrantOrRightLineItems" xlink:to="ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights" xlink:title="definition: ClassOfWarrantOrRightLineItems to ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights" order="4.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_WarrantsIssuedWeightedAverageExercisePrice" xlink:label="WarrantsIssuedWeightedAverageExercisePrice" xlink:title="WarrantsIssuedWeightedAverageExercisePrice"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ClassOfWarrantOrRightLineItems" xlink:to="WarrantsIssuedWeightedAverageExercisePrice" xlink:title="definition: ClassOfWarrantOrRightLineItems to WarrantsIssuedWeightedAverageExercisePrice" order="5.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_WarrantsExercisedWeightedAverageExercisePrice" xlink:label="WarrantsExercisedWeightedAverageExercisePrice" xlink:title="WarrantsExercisedWeightedAverageExercisePrice"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ClassOfWarrantOrRightLineItems" xlink:to="WarrantsExercisedWeightedAverageExercisePrice" xlink:title="definition: ClassOfWarrantOrRightLineItems to WarrantsExercisedWeightedAverageExercisePrice" order="6.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_WarrantsExpiredWeightedAverageExercisePrice" xlink:label="WarrantsExpiredWeightedAverageExercisePrice" xlink:title="WarrantsExpiredWeightedAverageExercisePrice"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ClassOfWarrantOrRightLineItems" xlink:to="WarrantsExpiredWeightedAverageExercisePrice" xlink:title="definition: ClassOfWarrantOrRightLineItems to WarrantsExpiredWeightedAverageExercisePrice" order="7.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassOfWarrantOrRightOutstanding" xlink:label="ClassOfWarrantOrRightOutstanding" xlink:title="ClassOfWarrantOrRightOutstanding"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ClassOfWarrantOrRightLineItems" xlink:to="ClassOfWarrantOrRightOutstanding" xlink:title="definition: ClassOfWarrantOrRightLineItems to ClassOfWarrantOrRightOutstanding" order="8.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesOther" xlink:label="StockIssuedDuringPeriodSharesOther" xlink:title="StockIssuedDuringPeriodSharesOther"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ClassOfWarrantOrRightLineItems" xlink:to="StockIssuedDuringPeriodSharesOther" xlink:title="definition: ClassOfWarrantOrRightLineItems to StockIssuedDuringPeriodSharesOther" order="9.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_WarrantsVoided" xlink:label="WarrantsVoided" xlink:title="WarrantsVoided"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ClassOfWarrantOrRightLineItems" xlink:to="WarrantsVoided" xlink:title="definition: ClassOfWarrantOrRightLineItems to WarrantsVoided" order="10.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_WarrantsExercisedShares" xlink:label="WarrantsExercisedShares" xlink:title="WarrantsExercisedShares"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ClassOfWarrantOrRightLineItems" xlink:to="WarrantsExercisedShares" xlink:title="definition: ClassOfWarrantOrRightLineItems to WarrantsExercisedShares" order="11.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_WarrantsExpired" xlink:label="WarrantsExpired" xlink:title="WarrantsExpired"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ClassOfWarrantOrRightLineItems" xlink:to="WarrantsExpired" xlink:title="definition: ClassOfWarrantOrRightLineItems to WarrantsExpired" order="12.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassOfWarrantOrRightTable" xlink:label="ClassOfWarrantOrRightTable" xlink:title="ClassOfWarrantOrRightTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="ClassOfWarrantOrRightLineItems" xlink:to="ClassOfWarrantOrRightTable" xlink:title="definition: ClassOfWarrantOrRightLineItems to ClassOfWarrantOrRightTable" order="13.0" t1:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_WarrantEventAxis" xlink:label="WarrantEventAxis" xlink:title="WarrantEventAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ClassOfWarrantOrRightTable" xlink:to="WarrantEventAxis" xlink:title="definition: ClassOfWarrantOrRightTable to WarrantEventAxis" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_WarrantEventDomain" xlink:label="WarrantEventDomain" xlink:title="WarrantEventDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="WarrantEventAxis" xlink:to="WarrantEventDomain" xlink:title="definition: WarrantEventAxis to WarrantEventDomain" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_WarrantEventDomain" xlink:label="WarrantEventDomain_2" xlink:title="WarrantEventDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="WarrantEventAxis" xlink:to="WarrantEventDomain_2" xlink:title="definition: WarrantEventAxis to WarrantEventDomain_2" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_WarrantsIssuedInConnectionWithPrivatePlacementMember" xlink:label="WarrantsIssuedInConnectionWithPrivatePlacementMember" xlink:title="WarrantsIssuedInConnectionWithPrivatePlacementMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="WarrantEventDomain" xlink:to="WarrantsIssuedInConnectionWithPrivatePlacementMember" xlink:title="definition: WarrantEventDomain to WarrantsIssuedInConnectionWithPrivatePlacementMember" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_WarrantsIssuedInConnectionWithConvertiblePromissoryNotesMember" xlink:label="WarrantsIssuedInConnectionWithConvertiblePromissoryNotesMember" xlink:title="WarrantsIssuedInConnectionWithConvertiblePromissoryNotesMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="WarrantEventDomain" xlink:to="WarrantsIssuedInConnectionWithConvertiblePromissoryNotesMember" xlink:title="definition: WarrantEventDomain to WarrantsIssuedInConnectionWithConvertiblePromissoryNotesMember" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_WarrantsIssuedInConnectionWithLineOfCreditWithRelatedPartyMember" xlink:label="WarrantsIssuedInConnectionWithLineOfCreditWithRelatedPartyMember" xlink:title="WarrantsIssuedInConnectionWithLineOfCreditWithRelatedPartyMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="WarrantEventDomain" xlink:to="WarrantsIssuedInConnectionWithLineOfCreditWithRelatedPartyMember" xlink:title="definition: WarrantEventDomain to WarrantsIssuedInConnectionWithLineOfCreditWithRelatedPartyMember" order="3.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_WarrantsIssuedInConnectionWithSeniorSecuredPromissoryNotesMember" xlink:label="WarrantsIssuedInConnectionWithSeniorSecuredPromissoryNotesMember" xlink:title="WarrantsIssuedInConnectionWithSeniorSecuredPromissoryNotesMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="WarrantEventDomain" xlink:to="WarrantsIssuedInConnectionWithSeniorSecuredPromissoryNotesMember" xlink:title="definition: WarrantEventDomain to WarrantsIssuedInConnectionWithSeniorSecuredPromissoryNotesMember" order="4.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_CallableWarrantsMember" xlink:label="CallableWarrantsMember" xlink:title="CallableWarrantsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="WarrantEventDomain" xlink:to="CallableWarrantsMember" xlink:title="definition: WarrantEventDomain to CallableWarrantsMember" order="5.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_WarrantsExpiredMember" xlink:label="WarrantsExpiredMember" xlink:title="WarrantsExpiredMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="WarrantEventDomain" xlink:to="WarrantsExpiredMember" xlink:title="definition: WarrantEventDomain to WarrantsExpiredMember" order="6.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_ContingentWarrantsRelatedToConvertibleNoteMember" xlink:label="ContingentWarrantsRelatedToConvertibleNoteMember" xlink:title="ContingentWarrantsRelatedToConvertibleNoteMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="WarrantEventDomain" xlink:to="ContingentWarrantsRelatedToConvertibleNoteMember" xlink:title="definition: WarrantEventDomain to ContingentWarrantsRelatedToConvertibleNoteMember" order="7.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_EquitySecuritiesOtherMember" xlink:label="EquitySecuritiesOtherMember" xlink:title="EquitySecuritiesOtherMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="WarrantEventDomain" xlink:to="EquitySecuritiesOtherMember" xlink:title="definition: WarrantEventDomain to EquitySecuritiesOtherMember" order="8.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_WarrantsRedeemedForCashlessExercisesMember" xlink:label="WarrantsRedeemedForCashlessExercisesMember" xlink:title="WarrantsRedeemedForCashlessExercisesMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="WarrantEventDomain" xlink:to="WarrantsRedeemedForCashlessExercisesMember" xlink:title="definition: WarrantEventDomain to WarrantsRedeemedForCashlessExercisesMember" order="9.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_RepurchaseOfCallableWarrantsMember" xlink:label="RepurchaseOfCallableWarrantsMember" xlink:title="RepurchaseOfCallableWarrantsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="WarrantEventDomain" xlink:to="RepurchaseOfCallableWarrantsMember" xlink:title="definition: WarrantEventDomain to RepurchaseOfCallableWarrantsMember" order="10.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PrivatePlacementMember" xlink:label="PrivatePlacementMember" xlink:title="PrivatePlacementMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="WarrantEventDomain" xlink:to="PrivatePlacementMember" xlink:title="definition: WarrantEventDomain to PrivatePlacementMember" order="11.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassOfWarrantOrRightAxis" xlink:label="ClassOfWarrantOrRightAxis" xlink:title="ClassOfWarrantOrRightAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ClassOfWarrantOrRightTable" xlink:to="ClassOfWarrantOrRightAxis" xlink:title="definition: ClassOfWarrantOrRightTable to ClassOfWarrantOrRightAxis" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="ClassOfWarrantOrRightDomain" xlink:title="ClassOfWarrantOrRightDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="ClassOfWarrantOrRightAxis" xlink:to="ClassOfWarrantOrRightDomain" xlink:title="definition: ClassOfWarrantOrRightAxis to ClassOfWarrantOrRightDomain" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="ClassOfWarrantOrRightDomain_2" xlink:title="ClassOfWarrantOrRightDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="ClassOfWarrantOrRightAxis" xlink:to="ClassOfWarrantOrRightDomain_2" xlink:title="definition: ClassOfWarrantOrRightAxis to ClassOfWarrantOrRightDomain_2" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_WarrantMember" xlink:label="WarrantMember" xlink:title="WarrantMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ClassOfWarrantOrRightDomain" xlink:to="WarrantMember" xlink:title="definition: ClassOfWarrantOrRightDomain to WarrantMember" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_ContingentWarrantsMember" xlink:label="ContingentWarrantsMember" xlink:title="ContingentWarrantsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ClassOfWarrantOrRightDomain" xlink:to="ContingentWarrantsMember" xlink:title="definition: ClassOfWarrantOrRightDomain to ContingentWarrantsMember" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredCompensationArrangementWithIndividualShareBasedPaymentsByTitleOfIndividualAxis" xlink:label="DeferredCompensationArrangementWithIndividualShareBasedPaymentsByTitleOfIndividualAxis" xlink:title="DeferredCompensationArrangementWithIndividualShareBasedPaymentsByTitleOfIndividualAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ClassOfWarrantOrRightTable" xlink:to="DeferredCompensationArrangementWithIndividualShareBasedPaymentsByTitleOfIndividualAxis" xlink:title="definition: ClassOfWarrantOrRightTable to DeferredCompensationArrangementWithIndividualShareBasedPaymentsByTitleOfIndividualAxis" order="3.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_TitleOfIndividualWithRelationshipToEntityDomain" xlink:label="TitleOfIndividualWithRelationshipToEntityDomain" xlink:title="TitleOfIndividualWithRelationshipToEntityDomain"/>
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<link:definitionLink xlink:type="extended" xlink:role="http://mimedx.com/role/RelatedPartyTransactionsDetails">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RelatedPartyTransactionLineItems" xlink:label="RelatedPartyTransactionLineItems" xlink:title="RelatedPartyTransactionLineItems"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty" xlink:label="RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty" xlink:title="RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="RelatedPartyTransactionLineItems" xlink:to="RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty" xlink:title="definition: RelatedPartyTransactionLineItems to RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_InterestExpenseRelatedParty" xlink:label="InterestExpenseRelatedParty" xlink:title="InterestExpenseRelatedParty"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="RelatedPartyTransactionLineItems" xlink:to="InterestExpenseRelatedParty" xlink:title="definition: RelatedPartyTransactionLineItems to InterestExpenseRelatedParty" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:label="ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:title="ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="RelatedPartyTransactionLineItems" xlink:to="ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:title="definition: RelatedPartyTransactionLineItems to ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" order="3.0" t1:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="PropertyPlantAndEquipmentByTypeAxis" xlink:title="PropertyPlantAndEquipmentByTypeAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:to="PropertyPlantAndEquipmentByTypeAxis" xlink:title="definition: ScheduleOfRelatedPartyTransactionsByRelatedPartyTable to PropertyPlantAndEquipmentByTypeAxis" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="PropertyPlantAndEquipmentTypeDomain" xlink:title="PropertyPlantAndEquipmentTypeDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="PropertyPlantAndEquipmentByTypeAxis" xlink:to="PropertyPlantAndEquipmentTypeDomain" xlink:title="definition: PropertyPlantAndEquipmentByTypeAxis to PropertyPlantAndEquipmentTypeDomain" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="PropertyPlantAndEquipmentTypeDomain_2" xlink:title="PropertyPlantAndEquipmentTypeDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="PropertyPlantAndEquipmentByTypeAxis" xlink:to="PropertyPlantAndEquipmentTypeDomain_2" xlink:title="definition: PropertyPlantAndEquipmentByTypeAxis to PropertyPlantAndEquipmentTypeDomain_2" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_OfficeSpaceLeaseMember" xlink:label="OfficeSpaceLeaseMember" xlink:title="OfficeSpaceLeaseMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="PropertyPlantAndEquipmentTypeDomain" xlink:to="OfficeSpaceLeaseMember" xlink:title="definition: PropertyPlantAndEquipmentTypeDomain to OfficeSpaceLeaseMember" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.sec.gov/sic/2011/sic-2011-01-31.xsd#sic_Z3721" xlink:label="Z3721" xlink:title="Z3721"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="PropertyPlantAndEquipmentTypeDomain" xlink:to="Z3721" xlink:title="definition: PropertyPlantAndEquipmentTypeDomain to Z3721" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ComponentOfOtherOperatingCostAndExpenseGeneralAxis" xlink:label="ComponentOfOtherOperatingCostAndExpenseGeneralAxis" xlink:title="ComponentOfOtherOperatingCostAndExpenseGeneralAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:to="ComponentOfOtherOperatingCostAndExpenseGeneralAxis" xlink:title="definition: ScheduleOfRelatedPartyTransactionsByRelatedPartyTable to ComponentOfOtherOperatingCostAndExpenseGeneralAxis" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ComponentOfOtherOperatingCostAndExpenseNameDomain" xlink:label="ComponentOfOtherOperatingCostAndExpenseNameDomain" xlink:title="ComponentOfOtherOperatingCostAndExpenseNameDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="ComponentOfOtherOperatingCostAndExpenseGeneralAxis" xlink:to="ComponentOfOtherOperatingCostAndExpenseNameDomain" xlink:title="definition: ComponentOfOtherOperatingCostAndExpenseGeneralAxis to ComponentOfOtherOperatingCostAndExpenseNameDomain" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ComponentOfOtherOperatingCostAndExpenseNameDomain" xlink:label="ComponentOfOtherOperatingCostAndExpenseNameDomain_2" xlink:title="ComponentOfOtherOperatingCostAndExpenseNameDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="ComponentOfOtherOperatingCostAndExpenseGeneralAxis" xlink:to="ComponentOfOtherOperatingCostAndExpenseNameDomain_2" xlink:title="definition: ComponentOfOtherOperatingCostAndExpenseGeneralAxis to ComponentOfOtherOperatingCostAndExpenseNameDomain_2" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember" xlink:label="SellingGeneralAndAdministrativeExpensesMember" xlink:title="SellingGeneralAndAdministrativeExpensesMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ComponentOfOtherOperatingCostAndExpenseNameDomain" xlink:to="SellingGeneralAndAdministrativeExpensesMember" xlink:title="definition: ComponentOfOtherOperatingCostAndExpenseNameDomain to SellingGeneralAndAdministrativeExpensesMember" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="LongtermDebtTypeAxis" xlink:title="LongtermDebtTypeAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:to="LongtermDebtTypeAxis" xlink:title="definition: ScheduleOfRelatedPartyTransactionsByRelatedPartyTable to LongtermDebtTypeAxis" order="3.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="LongtermDebtTypeDomain" xlink:title="LongtermDebtTypeDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="LongtermDebtTypeAxis" xlink:to="LongtermDebtTypeDomain" xlink:title="definition: LongtermDebtTypeAxis to LongtermDebtTypeDomain" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="LongtermDebtTypeDomain_2" xlink:title="LongtermDebtTypeDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="LongtermDebtTypeAxis" xlink:to="LongtermDebtTypeDomain_2" xlink:title="definition: LongtermDebtTypeAxis to LongtermDebtTypeDomain_2" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_HybridDebtInstrumentMember" xlink:label="HybridDebtInstrumentMember" xlink:title="HybridDebtInstrumentMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="LongtermDebtTypeDomain" xlink:to="HybridDebtInstrumentMember" xlink:title="definition: LongtermDebtTypeDomain to HybridDebtInstrumentMember" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LineOfCreditMember" xlink:label="LineOfCreditMember" xlink:title="LineOfCreditMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="LongtermDebtTypeDomain" xlink:to="LineOfCreditMember" xlink:title="definition: LongtermDebtTypeDomain to LineOfCreditMember" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_ConvertibleSeniorSecuredPromissoryNotesMember" xlink:label="ConvertibleSeniorSecuredPromissoryNotesMember" xlink:title="ConvertibleSeniorSecuredPromissoryNotesMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="LongtermDebtTypeDomain" xlink:to="ConvertibleSeniorSecuredPromissoryNotesMember" xlink:title="definition: LongtermDebtTypeDomain to ConvertibleSeniorSecuredPromissoryNotesMember" order="3.0"/>
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<link:definitionLink xlink:type="extended" xlink:role="http://mimedx.com/role/KPlanDetails"/>
<link:definitionLink xlink:type="extended" xlink:role="http://mimedx.com/role/CommitmentsDetails"/>
<link:definitionLink xlink:type="extended" xlink:role="http://mimedx.com/role/SubsequentEventsDetails">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SubsequentEventLineItems" xlink:label="SubsequentEventLineItems" xlink:title="SubsequentEventLineItems"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AreaOfRealEstateProperty" xlink:label="AreaOfRealEstateProperty" xlink:title="AreaOfRealEstateProperty"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SubsequentEventLineItems" xlink:to="AreaOfRealEstateProperty" xlink:title="definition: SubsequentEventLineItems to AreaOfRealEstateProperty" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="mdxg-20121231.xsd#mdxg_InitialTermOfLease" xlink:label="InitialTermOfLease" xlink:title="InitialTermOfLease"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SubsequentEventLineItems" xlink:to="InitialTermOfLease" xlink:title="definition: SubsequentEventLineItems to InitialTermOfLease" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:label="OperatingLeasesFutureMinimumPaymentsDue" xlink:title="OperatingLeasesFutureMinimumPaymentsDue"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SubsequentEventLineItems" xlink:to="OperatingLeasesFutureMinimumPaymentsDue" xlink:title="definition: SubsequentEventLineItems to OperatingLeasesFutureMinimumPaymentsDue" order="3.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SecurityDeposit" xlink:label="SecurityDeposit" xlink:title="SecurityDeposit"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SubsequentEventLineItems" xlink:to="SecurityDeposit" xlink:title="definition: SubsequentEventLineItems to SecurityDeposit" order="4.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtConversionConvertedInstrumentAmount1" xlink:label="DebtConversionConvertedInstrumentAmount1" xlink:title="DebtConversionConvertedInstrumentAmount1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SubsequentEventLineItems" xlink:to="DebtConversionConvertedInstrumentAmount1" xlink:title="definition: SubsequentEventLineItems to DebtConversionConvertedInstrumentAmount1" order="5.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DebtConversionConvertedInstrumentSharesIssued1" xlink:label="DebtConversionConvertedInstrumentSharesIssued1" xlink:title="DebtConversionConvertedInstrumentSharesIssued1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SubsequentEventLineItems" xlink:to="DebtConversionConvertedInstrumentSharesIssued1" xlink:title="definition: SubsequentEventLineItems to DebtConversionConvertedInstrumentSharesIssued1" order="6.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SubsequentEventTable" xlink:label="SubsequentEventTable" xlink:title="SubsequentEventTable"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="SubsequentEventLineItems" xlink:to="SubsequentEventTable" xlink:title="definition: SubsequentEventLineItems to SubsequentEventTable" order="7.0" t1:contextElement="segment"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="SubsequentEventTypeAxis" xlink:title="SubsequentEventTypeAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="SubsequentEventTable" xlink:to="SubsequentEventTypeAxis" xlink:title="definition: SubsequentEventTable to SubsequentEventTypeAxis" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="SubsequentEventTypeDomain" xlink:title="SubsequentEventTypeDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="SubsequentEventTypeAxis" xlink:to="SubsequentEventTypeDomain" xlink:title="definition: SubsequentEventTypeAxis to SubsequentEventTypeDomain" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="SubsequentEventTypeDomain_2" xlink:title="SubsequentEventTypeDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="SubsequentEventTypeAxis" xlink:to="SubsequentEventTypeDomain_2" xlink:title="definition: SubsequentEventTypeAxis to SubsequentEventTypeDomain_2" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="SubsequentEventMember" xlink:title="SubsequentEventMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="SubsequentEventTypeDomain" xlink:to="SubsequentEventMember" xlink:title="definition: SubsequentEventTypeDomain to SubsequentEventMember" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FinancingAxis" xlink:label="FinancingAxis" xlink:title="FinancingAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="SubsequentEventTable" xlink:to="FinancingAxis" xlink:title="definition: SubsequentEventTable to FinancingAxis" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FinancingDomain" xlink:label="FinancingDomain" xlink:title="FinancingDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="FinancingAxis" xlink:to="FinancingDomain" xlink:title="definition: FinancingAxis to FinancingDomain" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FinancingDomain" xlink:label="FinancingDomain_2" xlink:title="FinancingDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="FinancingAxis" xlink:to="FinancingDomain_2" xlink:title="definition: FinancingAxis to FinancingDomain_2" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IssuanceOfEquityMember" xlink:label="IssuanceOfEquityMember" xlink:title="IssuanceOfEquityMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="FinancingDomain" xlink:to="IssuanceOfEquityMember" xlink:title="definition: FinancingDomain to IssuanceOfEquityMember" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="RelatedPartyTransactionsByRelatedPartyAxis" xlink:title="RelatedPartyTransactionsByRelatedPartyAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="SubsequentEventTable" xlink:to="RelatedPartyTransactionsByRelatedPartyAxis" xlink:title="definition: SubsequentEventTable to RelatedPartyTransactionsByRelatedPartyAxis" order="3.0"/>
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<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="RelatedPartyTransactionsByRelatedPartyAxis" xlink:to="RelatedPartyDomain" xlink:title="definition: RelatedPartyTransactionsByRelatedPartyAxis to RelatedPartyDomain" order="1.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="RelatedPartyDomain_2" xlink:title="RelatedPartyDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="RelatedPartyTransactionsByRelatedPartyAxis" xlink:to="RelatedPartyDomain_2" xlink:title="definition: RelatedPartyTransactionsByRelatedPartyAxis to RelatedPartyDomain_2" order="2.0"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BoardOfDirectorsChairmanMember" xlink:label="BoardOfDirectorsChairmanMember" xlink:title="BoardOfDirectorsChairmanMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="RelatedPartyDomain" xlink:to="BoardOfDirectorsChairmanMember" xlink:title="definition: RelatedPartyDomain to BoardOfDirectorsChairmanMember" order="1.0"/>
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