| | | | | | | | | | | | | | | | | | | | | |
<?xml version="1.0" encoding="windows-1252"?> |
<!-- XBRL Document Created with Wdesk from Workiva --> |
<!-- Copyright 2021 Workiva --> |
<!-- r:bd31dae9-32cf-472e-92b3-8dd4bab789fd,g:8691cfc0-b8d7-43b3-b784-33d474882372 --> |
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"> |
| <link:roleRef roleURI="http://www.exactsciences.com/role/CoverPage" xlink:type="simple" xlink:href="exas-20210303.xsd#CoverPage"/> |
| <link:presentationLink xlink:role="http://www.exactsciences.com/role/CoverPage" xlink:type="extended"> |
| | <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_a9f3127a-48c5-421d-a7a4-599c0808a973" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CoverAbstract"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_89c9b703-c817-4689-acf1-32adaedf15b6" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentType"/> |
| | <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a9f3127a-48c5-421d-a7a4-599c0808a973" xlink:to="loc_dei_DocumentType_89c9b703-c817-4689-acf1-32adaedf15b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_e54af238-a4a6-4344-8f00-753ffe81c550" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentPeriodEndDate"/> |
| | <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a9f3127a-48c5-421d-a7a4-599c0808a973" xlink:to="loc_dei_DocumentPeriodEndDate_e54af238-a4a6-4344-8f00-753ffe81c550" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_1b71b9f5-1be7-41b3-abea-72ee903fab93" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityRegistrantName"/> |
| | <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a9f3127a-48c5-421d-a7a4-599c0808a973" xlink:to="loc_dei_EntityRegistrantName_1b71b9f5-1be7-41b3-abea-72ee903fab93" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_39fea8af-5e9f-4adc-a8a5-73baa76ee404" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityCentralIndexKey"/> |
| | <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a9f3127a-48c5-421d-a7a4-599c0808a973" xlink:to="loc_dei_EntityCentralIndexKey_39fea8af-5e9f-4adc-a8a5-73baa76ee404" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_e7b6129a-732b-4bf2-8307-d1693f61ad35" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CurrentFiscalYearEndDate"/> |
| | <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a9f3127a-48c5-421d-a7a4-599c0808a973" xlink:to="loc_dei_CurrentFiscalYearEndDate_e7b6129a-732b-4bf2-8307-d1693f61ad35" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_64f1d22b-2166-419b-af34-791c7d948ec2" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_AmendmentFlag"/> |
| | <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a9f3127a-48c5-421d-a7a4-599c0808a973" xlink:to="loc_dei_AmendmentFlag_64f1d22b-2166-419b-af34-791c7d948ec2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_6540b053-3657-449a-93eb-ce4a21772901" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityIncorporationStateCountryCode"/> |
| | <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a9f3127a-48c5-421d-a7a4-599c0808a973" xlink:to="loc_dei_EntityIncorporationStateCountryCode_6540b053-3657-449a-93eb-ce4a21772901" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_de6f0eae-82d1-4335-b5d8-787c3cafdd38" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityFileNumber"/> |
| | <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a9f3127a-48c5-421d-a7a4-599c0808a973" xlink:to="loc_dei_EntityFileNumber_de6f0eae-82d1-4335-b5d8-787c3cafdd38" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_f4a44df0-e822-446e-8f8f-424765a6026c" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityTaxIdentificationNumber"/> |
| | <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a9f3127a-48c5-421d-a7a4-599c0808a973" xlink:to="loc_dei_EntityTaxIdentificationNumber_f4a44df0-e822-446e-8f8f-424765a6026c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_3981cb5d-de52-4839-8276-9ac17ded2461" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressAddressLine1"/> |
| | <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a9f3127a-48c5-421d-a7a4-599c0808a973" xlink:to="loc_dei_EntityAddressAddressLine1_3981cb5d-de52-4839-8276-9ac17ded2461" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_a498551e-a7ce-4401-9f29-6d756e47ee2b" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressCityOrTown"/> |
| | <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a9f3127a-48c5-421d-a7a4-599c0808a973" xlink:to="loc_dei_EntityAddressCityOrTown_a498551e-a7ce-4401-9f29-6d756e47ee2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_8185be0d-2169-4a18-8cd3-b32f5cb542c8" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressStateOrProvince"/> |
| | <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a9f3127a-48c5-421d-a7a4-599c0808a973" xlink:to="loc_dei_EntityAddressStateOrProvince_8185be0d-2169-4a18-8cd3-b32f5cb542c8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_762d548a-0ef0-4807-8a2a-fb5d65341552" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressPostalZipCode"/> |
| | <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a9f3127a-48c5-421d-a7a4-599c0808a973" xlink:to="loc_dei_EntityAddressPostalZipCode_762d548a-0ef0-4807-8a2a-fb5d65341552" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_dc162fa7-1b1e-4f3b-9205-4cb46c9f3c25" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CityAreaCode"/> |
| | <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a9f3127a-48c5-421d-a7a4-599c0808a973" xlink:to="loc_dei_CityAreaCode_dc162fa7-1b1e-4f3b-9205-4cb46c9f3c25" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_edfd1700-543a-43c6-b018-1dac9c0e60a3" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_LocalPhoneNumber"/> |
| | <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a9f3127a-48c5-421d-a7a4-599c0808a973" xlink:to="loc_dei_LocalPhoneNumber_edfd1700-543a-43c6-b018-1dac9c0e60a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_a5643c4e-434a-49f6-a77a-c3b3cbae1cee" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_WrittenCommunications"/> |
| | <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a9f3127a-48c5-421d-a7a4-599c0808a973" xlink:to="loc_dei_WrittenCommunications_a5643c4e-434a-49f6-a77a-c3b3cbae1cee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_c195bd9a-ec91-45b4-baea-c18346f76b30" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_SolicitingMaterial"/> |
| | <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a9f3127a-48c5-421d-a7a4-599c0808a973" xlink:to="loc_dei_SolicitingMaterial_c195bd9a-ec91-45b4-baea-c18346f76b30" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_dffc4afa-d638-4ddd-bfbc-db7b6ec94ddd" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_PreCommencementTenderOffer"/> |
| | <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a9f3127a-48c5-421d-a7a4-599c0808a973" xlink:to="loc_dei_PreCommencementTenderOffer_dffc4afa-d638-4ddd-bfbc-db7b6ec94ddd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_dd8e6597-ae37-4779-87cf-448728bbcede" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_PreCommencementIssuerTenderOffer"/> |
| | <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a9f3127a-48c5-421d-a7a4-599c0808a973" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_dd8e6597-ae37-4779-87cf-448728bbcede" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_118a03d6-e89a-4bc7-918c-55b6bcbee553" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_Security12bTitle"/> |
| | <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a9f3127a-48c5-421d-a7a4-599c0808a973" xlink:to="loc_dei_Security12bTitle_118a03d6-e89a-4bc7-918c-55b6bcbee553" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_6a3b86f3-e2be-46e8-98af-bf6735c240d6" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_TradingSymbol"/> |
| | <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a9f3127a-48c5-421d-a7a4-599c0808a973" xlink:to="loc_dei_TradingSymbol_6a3b86f3-e2be-46e8-98af-bf6735c240d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_26be6508-fce5-4a31-bd80-88161a548c13" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_SecurityExchangeName"/> |
| | <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a9f3127a-48c5-421d-a7a4-599c0808a973" xlink:to="loc_dei_SecurityExchangeName_26be6508-fce5-4a31-bd80-88161a548c13" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/> |
| | <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_b0a796e2-2c9d-42a7-a4fb-f20858e8f9ce" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityEmergingGrowthCompany"/> |
| | <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a9f3127a-48c5-421d-a7a4-599c0808a973" xlink:to="loc_dei_EntityEmergingGrowthCompany_b0a796e2-2c9d-42a7-a4fb-f20858e8f9ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/> |
| | </link:presentationLink> |
| </link:linkbase> |