| | | | | | | | | | | | | | | | | | | | | |
<?xml version="1.0" encoding="windows-1252"?> |
<!-- XBRL Document Created with Wdesk from Workiva --> |
<!-- Copyright 2021 Workiva --> |
<!-- r:ec0ab77a-4aa4-46e0-a92a-85adba038ba6,g:b176d4f7-5c80-4168-aaa6-b91b4ed6b4e2 --> |
<xs:schema xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:exas="http://www.exactsciences.com/20210318" attributeFormDefault="unqualified" elementFormDefault="qualified" targetNamespace="http://www.exactsciences.com/20210318"> |
| <xs:import namespace="http://www.w3.org/1999/xlink" schemaLocation="http://www.xbrl.org/2003/xlink-2003-12-31.xsd"/> |
| <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/> |
| <xs:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/> |
| <xs:import namespace="http://xbrl.sec.gov/dei/2019-01-31" schemaLocation="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd"/> |
| <xs:annotation> |
| | <xs:appinfo> |
| | | <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="exas-20210318_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple"/> |
| | | <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="exas-20210318_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:type="simple"/> |
| | | <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="exas-20210318_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:type="simple"/> |
| | | <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="exas-20210318_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:type="simple"/> |
| | | <link:roleType id="CoverPage" roleURI="http://www.exactsciences.com/role/CoverPage"> |
| <link:definition> 0001001 - Document - Cover Page </link:definition> |
| <link:usedOn> link:presentationLink </link:usedOn> |
| <link:usedOn> link:calculationLink </link:usedOn> |
| <link:usedOn> link:definitionLink </link:usedOn> |
| </link:roleType> |
| | | </xs:appinfo> |
| | </xs:annotation> |
| </xs:schema> |