| | | | | | | | | | | | | | | | | | | | | |
<?xml version="1.0" encoding="windows-1252"?> |
<xbrl xml:lang="en-US" xmlns="http://www.xbrl.org/2003/instance" xmlns:dei="http://xbrl.sec.gov/dei/2019-01-31" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink"> |
| <link:schemaRef xlink:href="uthr-20210505.xsd" xlink:type="simple"/> |
| <context id="i6422086b2d32496883e14c5483581774_D20210505-20210505"> |
| | <entity> |
| | | <identifier scheme="http://www.sec.gov/CIK"> 0001082554 </identifier> |
| | | </entity> |
| | <period> |
| | | <startDate> 2021-05-05 </startDate> |
| | | <endDate> 2021-05-05 </endDate> |
| | | </period> |
| | </context> |
| <dei:EntityCentralIndexKey contextRef="i6422086b2d32496883e14c5483581774_D20210505-20210505" id="id3VybDovL2RvY3MudjEvZG9jOjg0Mzc4NzVlMDc1ZDQxM2RiOTgzOWVmOTc4MTVkYzJlL3NlYzo4NDM3ODc1ZTA3NWQ0MTNkYjk4MzllZjk3ODE1ZGMyZV80L2ZyYWc6YjllMjcwNmFjYWExNGYyMDgyZmUwOGUyNTE0MGY1MGUvdGFibGU6ZjJhM2IzYWVjMDg3NDg4ZGJkZjcwYzQyYTY3MzhhNWEvdGFibGVyYW5nZTpmMmEzYjNhZWMwODc0ODhkYmRmNzBjNDJhNjczOGE1YV8yLTEtMS0xLTA_bcb696f3-c267-4fa5-86f4-578af223a034"> 0001082554 </dei:EntityCentralIndexKey> |
| <dei:AmendmentFlag contextRef="i6422086b2d32496883e14c5483581774_D20210505-20210505" id="id3VybDovL2RvY3MudjEvZG9jOjg0Mzc4NzVlMDc1ZDQxM2RiOTgzOWVmOTc4MTVkYzJlL3NlYzo4NDM3ODc1ZTA3NWQ0MTNkYjk4MzllZjk3ODE1ZGMyZV80L2ZyYWc6YjllMjcwNmFjYWExNGYyMDgyZmUwOGUyNTE0MGY1MGUvdGFibGU6ZjJhM2IzYWVjMDg3NDg4ZGJkZjcwYzQyYTY3MzhhNWEvdGFibGVyYW5nZTpmMmEzYjNhZWMwODc0ODhkYmRmNzBjNDJhNjczOGE1YV8zLTEtMS0xLTA_7084d6f4-4608-4bdb-8cb0-eb857f6ad7ac"> false </dei:AmendmentFlag> |
| <dei:DocumentType contextRef="i6422086b2d32496883e14c5483581774_D20210505-20210505" id="id3VybDovL2RvY3MudjEvZG9jOjg0Mzc4NzVlMDc1ZDQxM2RiOTgzOWVmOTc4MTVkYzJlL3NlYzo4NDM3ODc1ZTA3NWQ0MTNkYjk4MzllZjk3ODE1ZGMyZV8xL2ZyYWc6NDhiMTdiZjFmM2YwNDU2NTgwOTZjNTNjZGM3MGZlZjQvdGV4dHJlZ2lvbjo0OGIxN2JmMWYzZjA0NTY1ODA5NmM1M2NkYzcwZmVmNF8xNjEw_262da2c6-b9d9-4c51-8cce-f532584c41f1"> 8-K </dei:DocumentType> |
| <dei:DocumentPeriodEndDate contextRef="i6422086b2d32496883e14c5483581774_D20210505-20210505" id="id3VybDovL2RvY3MudjEvZG9jOjg0Mzc4NzVlMDc1ZDQxM2RiOTgzOWVmOTc4MTVkYzJlL3NlYzo4NDM3ODc1ZTA3NWQ0MTNkYjk4MzllZjk3ODE1ZGMyZV8xL2ZyYWc6NDhiMTdiZjFmM2YwNDU2NTgwOTZjNTNjZGM3MGZlZjQvdGV4dHJlZ2lvbjo0OGIxN2JmMWYzZjA0NTY1ODA5NmM1M2NkYzcwZmVmNF8yNzQ4Nzc5MDcxMDgx_055bb7ee-f536-45c5-b99a-7440f8217e78"> 2021-05-05 </dei:DocumentPeriodEndDate> |
| <dei:EntityRegistrantName contextRef="i6422086b2d32496883e14c5483581774_D20210505-20210505" id="id3VybDovL2RvY3MudjEvZG9jOjg0Mzc4NzVlMDc1ZDQxM2RiOTgzOWVmOTc4MTVkYzJlL3NlYzo4NDM3ODc1ZTA3NWQ0MTNkYjk4MzllZjk3ODE1ZGMyZV8xL2ZyYWc6NDhiMTdiZjFmM2YwNDU2NTgwOTZjNTNjZGM3MGZlZjQvdGV4dHJlZ2lvbjo0OGIxN2JmMWYzZjA0NTY1ODA5NmM1M2NkYzcwZmVmNF8xNjE0_5111c1c9-23ba-45d6-9e90-99b1c902ad4f"> United Therapeutics Corporation </dei:EntityRegistrantName> |
| <dei:EntityIncorporationStateCountryCode contextRef="i6422086b2d32496883e14c5483581774_D20210505-20210505" id="id3VybDovL2RvY3MudjEvZG9jOjg0Mzc4NzVlMDc1ZDQxM2RiOTgzOWVmOTc4MTVkYzJlL3NlYzo4NDM3ODc1ZTA3NWQ0MTNkYjk4MzllZjk3ODE1ZGMyZV8xL2ZyYWc6NDhiMTdiZjFmM2YwNDU2NTgwOTZjNTNjZGM3MGZlZjQvdGFibGU6Mzg2MjBlNGFiMWI2NGM3ZWEzYzBlNGZiZGU0NmE2N2IvdGFibGVyYW5nZTozODYyMGU0YWIxYjY0YzdlYTNjMGU0ZmJkZTQ2YTY3Yl8wLTAtMS0xLTA_712762e3-51f1-4be7-b165-845902e00f66"> DE </dei:EntityIncorporationStateCountryCode> |
| <dei:EntityFileNumber contextRef="i6422086b2d32496883e14c5483581774_D20210505-20210505" id="id3VybDovL2RvY3MudjEvZG9jOjg0Mzc4NzVlMDc1ZDQxM2RiOTgzOWVmOTc4MTVkYzJlL3NlYzo4NDM3ODc1ZTA3NWQ0MTNkYjk4MzllZjk3ODE1ZGMyZV8xL2ZyYWc6NDhiMTdiZjFmM2YwNDU2NTgwOTZjNTNjZGM3MGZlZjQvdGFibGU6Mzg2MjBlNGFiMWI2NGM3ZWEzYzBlNGZiZGU0NmE2N2IvdGFibGVyYW5nZTozODYyMGU0YWIxYjY0YzdlYTNjMGU0ZmJkZTQ2YTY3Yl8wLTEtMS0xLTA_cab176ad-4778-4cf1-bee4-e3de9a666ee9"> 000-26301 </dei:EntityFileNumber> |
| <dei:EntityTaxIdentificationNumber contextRef="i6422086b2d32496883e14c5483581774_D20210505-20210505" id="id3VybDovL2RvY3MudjEvZG9jOjg0Mzc4NzVlMDc1ZDQxM2RiOTgzOWVmOTc4MTVkYzJlL3NlYzo4NDM3ODc1ZTA3NWQ0MTNkYjk4MzllZjk3ODE1ZGMyZV8xL2ZyYWc6NDhiMTdiZjFmM2YwNDU2NTgwOTZjNTNjZGM3MGZlZjQvdGFibGU6Mzg2MjBlNGFiMWI2NGM3ZWEzYzBlNGZiZGU0NmE2N2IvdGFibGVyYW5nZTozODYyMGU0YWIxYjY0YzdlYTNjMGU0ZmJkZTQ2YTY3Yl8wLTItMS0xLTA_35139548-b8a1-479b-9a61-f7186a63d225"> 52-1984749 </dei:EntityTaxIdentificationNumber> |
| <dei:EntityAddressAddressLine1 contextRef="i6422086b2d32496883e14c5483581774_D20210505-20210505" id="id3VybDovL2RvY3MudjEvZG9jOjg0Mzc4NzVlMDc1ZDQxM2RiOTgzOWVmOTc4MTVkYzJlL3NlYzo4NDM3ODc1ZTA3NWQ0MTNkYjk4MzllZjk3ODE1ZGMyZV8xL2ZyYWc6NDhiMTdiZjFmM2YwNDU2NTgwOTZjNTNjZGM3MGZlZjQvdGFibGU6ZjZjODRlYmEzYzkxNDNlZGFhYjUwYzA5ZjRlZjNmMmQvdGFibGVyYW5nZTpmNmM4NGViYTNjOTE0M2VkYWFiNTBjMDlmNGVmM2YyZF8wLTAtMS0xLTA_f7bbf31a-edc8-4409-8387-68d9d5db72e3"> 1040 Spring Street </dei:EntityAddressAddressLine1> |
| <dei:EntityAddressCityOrTown contextRef="i6422086b2d32496883e14c5483581774_D20210505-20210505" id="id3VybDovL2RvY3MudjEvZG9jOjg0Mzc4NzVlMDc1ZDQxM2RiOTgzOWVmOTc4MTVkYzJlL3NlYzo4NDM3ODc1ZTA3NWQ0MTNkYjk4MzllZjk3ODE1ZGMyZV8xL2ZyYWc6NDhiMTdiZjFmM2YwNDU2NTgwOTZjNTNjZGM3MGZlZjQvdGFibGU6ZjZjODRlYmEzYzkxNDNlZGFhYjUwYzA5ZjRlZjNmMmQvdGFibGVyYW5nZTpmNmM4NGViYTNjOTE0M2VkYWFiNTBjMDlmNGVmM2YyZF8xLTAtMS0xLTA_66893111-a9b8-450f-8b59-eb897078da1d"> Silver Spring, </dei:EntityAddressCityOrTown> |
| <dei:EntityAddressStateOrProvince contextRef="i6422086b2d32496883e14c5483581774_D20210505-20210505" id="id3VybDovL2RvY3MudjEvZG9jOjg0Mzc4NzVlMDc1ZDQxM2RiOTgzOWVmOTc4MTVkYzJlL3NlYzo4NDM3ODc1ZTA3NWQ0MTNkYjk4MzllZjk3ODE1ZGMyZV8xL2ZyYWc6NDhiMTdiZjFmM2YwNDU2NTgwOTZjNTNjZGM3MGZlZjQvdGFibGU6ZjZjODRlYmEzYzkxNDNlZGFhYjUwYzA5ZjRlZjNmMmQvdGFibGVyYW5nZTpmNmM4NGViYTNjOTE0M2VkYWFiNTBjMDlmNGVmM2YyZF8yLTAtMS0xLTA_aeeca25b-4b04-42f0-aa2b-b5badc37110d"> MD </dei:EntityAddressStateOrProvince> |
| <dei:EntityAddressPostalZipCode contextRef="i6422086b2d32496883e14c5483581774_D20210505-20210505" id="id3VybDovL2RvY3MudjEvZG9jOjg0Mzc4NzVlMDc1ZDQxM2RiOTgzOWVmOTc4MTVkYzJlL3NlYzo4NDM3ODc1ZTA3NWQ0MTNkYjk4MzllZjk3ODE1ZGMyZV8xL2ZyYWc6NDhiMTdiZjFmM2YwNDU2NTgwOTZjNTNjZGM3MGZlZjQvdGFibGU6ZjZjODRlYmEzYzkxNDNlZGFhYjUwYzA5ZjRlZjNmMmQvdGFibGVyYW5nZTpmNmM4NGViYTNjOTE0M2VkYWFiNTBjMDlmNGVmM2YyZF8yLTEtMS0xLTA_954637dd-c482-4776-91e8-06e8d57150b0"> 20910 </dei:EntityAddressPostalZipCode> |
| <dei:CityAreaCode contextRef="i6422086b2d32496883e14c5483581774_D20210505-20210505" id="id3VybDovL2RvY3MudjEvZG9jOjg0Mzc4NzVlMDc1ZDQxM2RiOTgzOWVmOTc4MTVkYzJlL3NlYzo4NDM3ODc1ZTA3NWQ0MTNkYjk4MzllZjk3ODE1ZGMyZV8xL2ZyYWc6NDhiMTdiZjFmM2YwNDU2NTgwOTZjNTNjZGM3MGZlZjQvdGV4dHJlZ2lvbjo0OGIxN2JmMWYzZjA0NTY1ODA5NmM1M2NkYzcwZmVmNF8xNjA2_12d9fa53-b9fc-4497-8046-288fb2dc751d"> 301 </dei:CityAreaCode> |
| <dei:LocalPhoneNumber contextRef="i6422086b2d32496883e14c5483581774_D20210505-20210505" id="id3VybDovL2RvY3MudjEvZG9jOjg0Mzc4NzVlMDc1ZDQxM2RiOTgzOWVmOTc4MTVkYzJlL3NlYzo4NDM3ODc1ZTA3NWQ0MTNkYjk4MzllZjk3ODE1ZGMyZV8xL2ZyYWc6NDhiMTdiZjFmM2YwNDU2NTgwOTZjNTNjZGM3MGZlZjQvdGV4dHJlZ2lvbjo0OGIxN2JmMWYzZjA0NTY1ODA5NmM1M2NkYzcwZmVmNF8xNjEx_5faad9f8-fbc4-4e9f-8734-492a83864003"> 608-9292 </dei:LocalPhoneNumber> |
| <dei:WrittenCommunications contextRef="i6422086b2d32496883e14c5483581774_D20210505-20210505" id="id3VybDovL2RvY3MudjEvZG9jOjg0Mzc4NzVlMDc1ZDQxM2RiOTgzOWVmOTc4MTVkYzJlL3NlYzo4NDM3ODc1ZTA3NWQ0MTNkYjk4MzllZjk3ODE1ZGMyZV8xL2ZyYWc6NDhiMTdiZjFmM2YwNDU2NTgwOTZjNTNjZGM3MGZlZjQvdGV4dHJlZ2lvbjo0OGIxN2JmMWYzZjA0NTY1ODA5NmM1M2NkYzcwZmVmNF8xNjEy_12090b49-a1e7-4706-ae6c-3778844cc43c"> false </dei:WrittenCommunications> |
| <dei:SolicitingMaterial contextRef="i6422086b2d32496883e14c5483581774_D20210505-20210505" id="id3VybDovL2RvY3MudjEvZG9jOjg0Mzc4NzVlMDc1ZDQxM2RiOTgzOWVmOTc4MTVkYzJlL3NlYzo4NDM3ODc1ZTA3NWQ0MTNkYjk4MzllZjk3ODE1ZGMyZV8xL2ZyYWc6NDhiMTdiZjFmM2YwNDU2NTgwOTZjNTNjZGM3MGZlZjQvdGV4dHJlZ2lvbjo0OGIxN2JmMWYzZjA0NTY1ODA5NmM1M2NkYzcwZmVmNF8xNjEz_ddb1887f-fc25-4125-a913-45d1bb2fc0e2"> false </dei:SolicitingMaterial> |
| <dei:PreCommencementTenderOffer contextRef="i6422086b2d32496883e14c5483581774_D20210505-20210505" id="id3VybDovL2RvY3MudjEvZG9jOjg0Mzc4NzVlMDc1ZDQxM2RiOTgzOWVmOTc4MTVkYzJlL3NlYzo4NDM3ODc1ZTA3NWQ0MTNkYjk4MzllZjk3ODE1ZGMyZV8xL2ZyYWc6NDhiMTdiZjFmM2YwNDU2NTgwOTZjNTNjZGM3MGZlZjQvdGV4dHJlZ2lvbjo0OGIxN2JmMWYzZjA0NTY1ODA5NmM1M2NkYzcwZmVmNF8xNjA3_289ce699-880a-440e-a12b-e4d9e9a6ec37"> false </dei:PreCommencementTenderOffer> |
| <dei:PreCommencementIssuerTenderOffer contextRef="i6422086b2d32496883e14c5483581774_D20210505-20210505" id="id3VybDovL2RvY3MudjEvZG9jOjg0Mzc4NzVlMDc1ZDQxM2RiOTgzOWVmOTc4MTVkYzJlL3NlYzo4NDM3ODc1ZTA3NWQ0MTNkYjk4MzllZjk3ODE1ZGMyZV8xL2ZyYWc6NDhiMTdiZjFmM2YwNDU2NTgwOTZjNTNjZGM3MGZlZjQvdGV4dHJlZ2lvbjo0OGIxN2JmMWYzZjA0NTY1ODA5NmM1M2NkYzcwZmVmNF8xNjA4_12e08edc-31d0-4d60-a839-d1a352e655d6"> false </dei:PreCommencementIssuerTenderOffer> |
| <dei:Security12bTitle contextRef="i6422086b2d32496883e14c5483581774_D20210505-20210505" id="id3VybDovL2RvY3MudjEvZG9jOjg0Mzc4NzVlMDc1ZDQxM2RiOTgzOWVmOTc4MTVkYzJlL3NlYzo4NDM3ODc1ZTA3NWQ0MTNkYjk4MzllZjk3ODE1ZGMyZV8xL2ZyYWc6NDhiMTdiZjFmM2YwNDU2NTgwOTZjNTNjZGM3MGZlZjQvdGFibGU6NDY5YmNlZTI3YTJlNGI0NWIwNTc4NDk1NzkxMTQ5OTEvdGFibGVyYW5nZTo0NjliY2VlMjdhMmU0YjQ1YjA1Nzg0OTU3OTExNDk5MV8xLTAtMS0xLTA_e0996682-361f-433a-b997-8ece5d66d11b"> Common Stock, par value $0.01 per share </dei:Security12bTitle> |
| <dei:TradingSymbol contextRef="i6422086b2d32496883e14c5483581774_D20210505-20210505" id="id3VybDovL2RvY3MudjEvZG9jOjg0Mzc4NzVlMDc1ZDQxM2RiOTgzOWVmOTc4MTVkYzJlL3NlYzo4NDM3ODc1ZTA3NWQ0MTNkYjk4MzllZjk3ODE1ZGMyZV8xL2ZyYWc6NDhiMTdiZjFmM2YwNDU2NTgwOTZjNTNjZGM3MGZlZjQvdGFibGU6NDY5YmNlZTI3YTJlNGI0NWIwNTc4NDk1NzkxMTQ5OTEvdGFibGVyYW5nZTo0NjliY2VlMjdhMmU0YjQ1YjA1Nzg0OTU3OTExNDk5MV8xLTEtMS0xLTA_91a0438d-6fa7-4236-878f-1fd0d8a5d989"> UTHR </dei:TradingSymbol> |
| <dei:SecurityExchangeName contextRef="i6422086b2d32496883e14c5483581774_D20210505-20210505" id="id3VybDovL2RvY3MudjEvZG9jOjg0Mzc4NzVlMDc1ZDQxM2RiOTgzOWVmOTc4MTVkYzJlL3NlYzo4NDM3ODc1ZTA3NWQ0MTNkYjk4MzllZjk3ODE1ZGMyZV8xL2ZyYWc6NDhiMTdiZjFmM2YwNDU2NTgwOTZjNTNjZGM3MGZlZjQvdGFibGU6NDY5YmNlZTI3YTJlNGI0NWIwNTc4NDk1NzkxMTQ5OTEvdGFibGVyYW5nZTo0NjliY2VlMjdhMmU0YjQ1YjA1Nzg0OTU3OTExNDk5MV8xLTItMS0xLTA_f1418d62-03e7-4a09-9dd2-3f7fba1b2920"> NASDAQ </dei:SecurityExchangeName> |
| <dei:EntityEmergingGrowthCompany contextRef="i6422086b2d32496883e14c5483581774_D20210505-20210505" id="id3VybDovL2RvY3MudjEvZG9jOjg0Mzc4NzVlMDc1ZDQxM2RiOTgzOWVmOTc4MTVkYzJlL3NlYzo4NDM3ODc1ZTA3NWQ0MTNkYjk4MzllZjk3ODE1ZGMyZV8xL2ZyYWc6NDhiMTdiZjFmM2YwNDU2NTgwOTZjNTNjZGM3MGZlZjQvdGV4dHJlZ2lvbjo0OGIxN2JmMWYzZjA0NTY1ODA5NmM1M2NkYzcwZmVmNF8xNjA5_304da682-2929-4518-b17d-3bf32c4a924b"> false </dei:EntityEmergingGrowthCompany> |
| </xbrl> |