SEC Info - Sac Capital Advisors LLC, et al. - ‘SC 13G/A’ on 1/12/09 re: Orexigen Therapeutics Inc

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Sac Capital Advisors LLC, et al. – ‘SC 13G/A’ on 1/12/09 re: Orexigen Therapeutics Inc

On: Monday, 1/12/09, at 5:20pm ET · Accession #: 899140-9-109 · File #: 5-83578

  As Of                Filer                Filing    For·On·As Docs:Size              Issuer               Agent

 1/12/09  Sac Capital Advisors LLC          SC 13G/A               1:18K  Orexigen Therapeutics Inc         Willkie Fa… Gallagher/FA
          CR Intrinsic Investors, LLC
          S.A.C. Capital Management, LLC
          Steven A. Cohen

Amendment to Statement of Beneficial Ownership — Schedule 13G
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: SC 13G/A    First Amendment                                       10     35K

Document Table of Contents

Page	(sequential)	\|	(alphabetic)	Top
			Alternative Formats (Word, et al.) Address of Issuer's Principal Executive Offices: Address of Principal Business Office: Certification: Citizenship: CUSIP Number: Identification and Classification of Members Identification and Classification of the Name of Issuer: Name of Person Filing: Not Applicable Notice of Dissolution of Group: Ownership: Ownership of Five Percent or Less of a Class: Ownership of More than Five Percent on Behalf of Another Title of Class of Securities:
1	1st Page - Filing Submission
6	Item 1(a). Name of Issuer:
"	Item 1(b). Address of Issuer's Principal Executive Offices:
"	Items 2(a). Name of Person Filing:
"	Item 2(b). Address of Principal Business Office:
"	Item 2(c). Citizenship:
"	Item 2(d). Title of Class of Securities:
7	Item 2(e). CUSIP Number:
"	Item 3. Not Applicable
"	Item 4. Ownership:
8	Item 5. Ownership of Five Percent or Less of a Class:
"	Item 6. Ownership of More than Five Percent on Behalf of Another
"	Item 7. Identification and Classification of the
9	Item 8. Identification and Classification of Members
"	Item 9. Notice of Dissolution of Group:
"	Item 10. Certification:

SC 13G/A 1st Page of 10 TOC ↑Top Previous Next ↓Bottom Just 1st
 
 UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

 Under the Securities Exchange Act of 1934
(Amendment No. 1)*

 OREXIGEN THERAPEUTICS, INC.
 ---------------------------
(Name of Issuer)

Common Stock, $0.001 Par Value Per Share
----------------------------------------
(Title of Class of Securities)

 686164104
 ---------
(CUSIP Number)

 December 31, 2008
 -----------------
(Date of Event which Requires Filing
of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule 
is filed:                                                                       

[ ]      Rule 13d-1(b)                      
[X]      Rule 13d-1(c)                      
[ ]      Rule 13d-1(d)                      

  *The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities,
 and for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.                                 

The information required on the remainder of this cover page shall not be   
 deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
  Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
 the Act but shall be subject to all other provisions of the Act (however, see
the Notes).                                                                 

Page 1 of 10

SC 13G/A 2nd Page of 10 TOC 1st Previous Next ↓Bottom Just 2nd
---------------------------                               ----------------------
CUSIP No. 686164104                      13G              Page 2 of 10 Pages    
---------------------------                               ----------------------

---------- ---------------------------------------------------------------------
1  NAME OF REPORTING PERSON                                     
I.R.S. IDENTIFICATION NO. OF ABOVE PERSON                 

S.A.C. Capital Advisors, LLC                              
---------- ---------------------------------------------------------------------
2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            
                                                                 (a) [ ]
                                                                 (b) [X]
---------- ---------------------------------------------------------------------
3  SEC USE ONLY                                                 
---------- ---------------------------------------------------------------------
4  CITIZENSHIP OR PLACE OF ORGANIZATION                         

Delaware                                                  
--------------------- ----- ----------------------------------------------------
5  SOLE VOTING POWER          

0                       
                      ----- ----------------------------------------------------
6  SHARED VOTING POWER        
NUMBER OF SHARES                                                                
BENEFICIALLY OWNED          349,300 (see Item 4)                                
BY EACH REPORTING     ----- ----------------------------------------------------
PERSON WITH              7  SOLE DISPOSITIVE POWER                              

0                       
                      ----- ----------------------------------------------------
8  SHARED DISPOSITIVE POWER   

349,300 (see Item 4)    
---------- ---------------------------------------------------------------------
9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 

349,300 (see Item 4)                                      
---------- ---------------------------------------------------------------------
      10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

[ ]                                                       
---------- ---------------------------------------------------------------------
11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)             

1.0% (see Item 4)                                         
---------- ---------------------------------------------------------------------
12  TYPE OF REPORTING PERSON*                                     

00                                                        
---------- ---------------------------------------------------------------------
 *SEE INSTRUCTION BEFORE FILLING OUT

Page 2 of 10

SC 13G/A 3rd Page of 10 TOC 1st Previous Next ↓Bottom Just 3rd
---------------------------                               ----------------------
CUSIP No. 686164104                      13G              Page 3 of 10 Pages    
---------------------------                               ----------------------

---------- ---------------------------------------------------------------------
1  NAME OF REPORTING PERSON                                     
I.R.S. IDENTIFICATION NO. OF ABOVE PERSON                 

S.A.C. Capital Management, LLC                            
---------- ---------------------------------------------------------------------
2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            
                                                                 (a) [ ]
                                                                 (b) [X]
---------- ---------------------------------------------------------------------
3  SEC USE ONLY                                                 
---------- ---------------------------------------------------------------------
4  CITIZENSHIP OR PLACE OF ORGANIZATION                         

Delaware                                                  
--------------------- ----- ----------------------------------------------------
5  SOLE VOTING POWER          

0                       
                      ----- ----------------------------------------------------
6  SHARED VOTING POWER        
NUMBER OF SHARES                                                                
BENEFICIALLY OWNED          349,300 (see Item 4)                                
BY EACH REPORTING     ----- ----------------------------------------------------
PERSON WITH              7  SOLE DISPOSITIVE POWER                              

0                       
                      ----- ----------------------------------------------------
8  SHARED DISPOSITIVE POWER   

349,300 (see Item 4)    
---------- ---------------------------------------------------------------------
9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 

349,300 (see Item 4)                                      
---------- ---------------------------------------------------------------------
      10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

[ ]                                                       
---------- ---------------------------------------------------------------------
11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)             

1.0% (see Item 4)                                         
---------- ---------------------------------------------------------------------
12  TYPE OF REPORTING PERSON*                                     

00                                                        
---------- ---------------------------------------------------------------------
 *SEE INSTRUCTION BEFORE FILLING OUT

Page 3 of 10

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---------------------------                               ----------------------
CUSIP No. 686164104                      13G              Page 4 of 10 Pages    
---------------------------                               ----------------------

---------- ---------------------------------------------------------------------
1  NAME OF REPORTING PERSON                                     
I.R.S. IDENTIFICATION NO. OF ABOVE PERSON                 

CR Intrinsic Investors, LLC                               
---------- ---------------------------------------------------------------------
2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            
                                                                 (a) [ ]
                                                                 (b) [X]
---------- ---------------------------------------------------------------------
3  SEC USE ONLY                                                 
---------- ---------------------------------------------------------------------
4  CITIZENSHIP OR PLACE OF ORGANIZATION                         

Delaware                                                  
--------------------- ----- ----------------------------------------------------
5  SOLE VOTING POWER          

0                       
                      ----- ----------------------------------------------------
6  SHARED VOTING POWER        
NUMBER OF SHARES                                                                
BENEFICIALLY OWNED          1,340,000 (see Item 4)                              
BY EACH REPORTING     ----- ----------------------------------------------------
PERSON WITH              7  SOLE DISPOSITIVE POWER                              

0                       
                      ----- ----------------------------------------------------
8  SHARED DISPOSITIVE POWER   

1,340,000 (see Item 4)  
---------- ---------------------------------------------------------------------
9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 

1,340,000 (see Item 4)                                    
---------- ---------------------------------------------------------------------
      10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

[ ]                                                       
---------- ---------------------------------------------------------------------
11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)             

3.9% (see Item 4)                                         
---------- ---------------------------------------------------------------------
12  TYPE OF REPORTING PERSON*                                     

00                                                        
---------- ---------------------------------------------------------------------
 *SEE INSTRUCTION BEFORE FILLING OUT

Page 4 of 10

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---------------------------                               ----------------------
CUSIP No. 686164104                      13G              Page 5 of 10 Pages    
---------------------------                               ----------------------

---------- ---------------------------------------------------------------------
1  NAME OF REPORTING PERSON                                     
I.R.S. IDENTIFICATION NO. OF ABOVE PERSON                 

Steven A. Cohen                                           
---------- ---------------------------------------------------------------------
2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            
                                                                 (a) [ ]
                                                                 (b) [X]
---------- ---------------------------------------------------------------------
3  SEC USE ONLY                                                 
---------- ---------------------------------------------------------------------
4  CITIZENSHIP OR PLACE OF ORGANIZATION                         

United States                                             
--------------------- ----- ----------------------------------------------------
5  SOLE VOTING POWER          

0                       
                      ----- ----------------------------------------------------
6  SHARED VOTING POWER        
NUMBER OF SHARES                                                                
BENEFICIALLY OWNED          1,689,300 (see Item 4)                              
BY EACH REPORTING     ----- ----------------------------------------------------
PERSON WITH              7  SOLE DISPOSITIVE POWER                              

0                       
                      ----- ----------------------------------------------------
8  SHARED DISPOSITIVE POWER   

1,689,300 (see Item 4)  
---------- ---------------------------------------------------------------------
9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 

1,689,300 (see Item 4)                                    
---------- ---------------------------------------------------------------------
      10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

[ ]                                                       
---------- ---------------------------------------------------------------------
11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)             

4.9% (see Item 4)                                         
---------- ---------------------------------------------------------------------
12  TYPE OF REPORTING PERSON*                                     

IN                                                        
---------- ---------------------------------------------------------------------
 *SEE INSTRUCTION BEFORE FILLING OUT

Page 5 of 10

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Item 1(a)           Name of Issuer:                                             
--------------                          

Orexigen Therapeutics, Inc.             

Item 1(b)           Address of Issuer's Principal Executive Offices:            
       -----------------------------------------------

                    3344 North Torrey Pines Court, Suite 200, La Jolla, CA 92037

Items 2(a)          Name of Person Filing:                                      
---------------------                   

                    This statement is filed by: (i) S.A.C. Capital Advisors, LLC
                 ("SAC Capital Advisors") with respect to shares of common
                   stock, $0.001 par value per share ("Shares"), of the Issuer
                  beneficially owned by S.A.C. Capital Associates, LLC ("SAC
                  Capital Associates") and S.A.C. MultiQuant Fund, LLC ("SAC
                    MultiQuant Fund"); (ii) S.A.C. Capital Management, LLC ("SAC
                Capital Management") with respect to Shares beneficially
                owned by SAC Capital Associates and SAC MultiQuant Fund;
                    (iii) CR Intrinsic Investors, LLC ("CR Intrinsic Investors")
                 with respect to Shares beneficially owned by CR Intrinsic
               Investments, LLC ("CR Intrinsic Investments"); and (iv)
                    Steven A. Cohen with respect to Shares beneficially owned by
                 SAC Capital Advisors, SAC Capital Management, SAC Capital
                   Associates, SAC MultiQuant Fund, CR Intrinsic Investors and
CR Intrinsic Investments.               

Item 2(b)           Address of Principal Business Office:                       
------------------------------------    

               The address of the principal business office of (i) SAC
                    Capital Advisors, CR Intrinsic Investors and Mr. Cohen is 72
                 Cummings Point Road, Stamford, Connecticut 06902 and (ii)
                   SAC Capital Management is 540 Madison Avenue, New York, New
York 10022.                             

Item 2(c)           Citizenship:                                                
-----------                             

           SAC Capital Advisors, SAC Capital Management and CR
          Intrinsic Investors are Delaware limited liability
        companies. Mr. Cohen is a United States citizen.

Item 2(d)           Title of Class of Securities:                               
----------------------------            

Common Stock, $0.001 par value per share

Page 6 of 10

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Item 2(e)           CUSIP Number:                                               
------------                            

686164104                               

Item 3              Not Applicable                                              

Item 4              Ownership:                                                  
---------                               

                 The percentages used herein are calculated based upon the
               Shares issued and outstanding as of November 3, 2008 as
                    reported on the Issuer's quarterly report on Form 10-Q filed
           with the Securities and Exchange Commission for the
  quarterly period ended September 30, 2008.

         As of the close of business on December 31, 2008:

1. S.A.C. Capital Advisors, LLC         
 (a)    Amount beneficially owned: 349,300
(b)    Percent of class: 1.0%           
         (c)(i) Sole power to vote or direct the vote: -0-
               (ii)   Shared power to vote or direct the vote: 349,300
                   (iii)  Sole power to dispose or direct the disposition: -0-
                 (iv)   Shared power to dispose or direct the disposition:
349,300                   

2. S.A.C. Capital Management, LLC       
 (a)    Amount beneficially owned: 349,300
(b)    Percent of class: 1.0%           
         (c)(i) Sole power to vote or direct the vote: -0-
               (ii)   Shared power to vote or direct the vote: 349,300
                   (iii)  Sole power to dispose or direct the disposition: -0-
                 (iv)   Shared power to dispose or direct the disposition:
349,300                   

3. CR Intrinsic Investors, LLC          
   (a)    Amount beneficially owned: 1,340,000
(b)    Percent of class: 3.9%           
         (c)(i) Sole power to vote or direct the vote: -0-
                 (ii)   Shared power to vote or direct the vote: 1,340,000
                   (iii)  Sole power to dispose or direct the disposition: -0-
                 (iv)   Shared power to dispose or direct the disposition:
1,340,000                 

4. Steven A. Cohen                      
   (a)    Amount beneficially owned: 1,689,300
(b)    Percent of class: 4.9%           
         (c)(i) Sole power to vote or direct the vote: -0-
                 (ii)   Shared power to vote or direct the vote: 1,689,300

Page 7 of 10

SC 13G/A 8th Page of 10 TOC 1st Previous Next ↓Bottom Just 8th
                   (iii)  Sole power to dispose or direct the disposition: -0-
                 (iv)   Shared power to dispose or direct the disposition:
1,689,300                 

                  SAC Capital Advisors, SAC Capital Management, CR Intrinsic
               Investors and Mr. Cohen do not directly own any Shares.
                 Pursuant to investment management agreements in effect at
              the time, each of SAC Capital Advisors and SAC Capital
              Management shared all investment and voting power with
                    respect to the securities held by SAC Capital Associates and
                 SAC MultiQuant Fund. Pursuant to an investment management
                  agreement, CR Intrinsic Investors maintains investment and
              voting power with respect to the securities held by CR
             Intrinsic Investments. Mr. Cohen controls each of SAC
                 Capital Advisors, SAC Capital Management and CR Intrinsic
             Investors. CR Intrinsic Investments is a wholly owned
                subsidiary of SAC Capital Associates. As of December 31,
              2008, by reason of the provisions of Rule 13d-3 of the
                    Securities Exchange Act of 1934, as amended, each of (i) SAC
                  Capital Advisors, SAC Capital Management and Mr. Cohen may
                  be deemed to own beneficially 349,300 Shares (constituting
                 approximately 1.0% of the Shares outstanding) and (ii) CR
              Intrinsic Investors and Mr. Cohen may be deemed to own
                 beneficially 1,340,000 Shares (constituting approximately
            3.9% of the Shares outstanding). Each of SAC Capital
                    Advisors, SAC Capital Management, CR Intrinsic Investors and
              Mr. Cohen disclaims beneficial ownership of any of the
             securities covered by this statement, and SAC Capital
                   Associates disclaims beneficial ownership of any securities
held by CR Intrinsic Investments.       

Item 5              Ownership of Five Percent or Less of a Class:               
    --------------------------------------------

                   If this statement is being filed to report the fact that as
                    of the date hereof the reporting person has ceased to be the
                  beneficial owner of more than five percent of the class of
securities, check the following.   [X]  

Item 6              Ownership of More than Five Percent on Behalf of Another    
                --------------------------------------------------------
Person:                                 
------                                  

Not Applicable                          

Item 7              Identification and Classification of the                    
----------------------------------------
    Subsidiary Which Acquired the Security Being
    --------------------------------------------
  Reported on By the Parent Holding Company:
 -----------------------------------------

Not Applicable                          

Page 8 of 10

SC 13G/A 9th Page of 10 TOC 1st Previous Next ↓Bottom Just 9th
Item 8              Identification and Classification of Members                
    --------------------------------------------
of the Group:                           
------------                            

Not Applicable                          

Item 9              Notice of Dissolution of Group:                             
------------------------------          

Not Applicable                          

Item 10             Certification:                                              
-------------                           

     By signing below the signatory certifies that, to the best of his knowledge
and belief, the securities referred to above were not acquired and are not held 
for the purpose of or with the effect of changing or influencing the control of 
the issuer of the securities and were not acquired and are not held in          
connection with or as a participant in any transaction having that purpose or   
effect.                                                                         

Page 9 of 10

SC 13G/A Last Page of 10 TOC 1st Previous Next ↓Bottom Just 10th
 SIGNATURE
 ---------

After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and  
correct.                                                                        

Dated: January 12, 2009                                                         

S.A.C. CAPITAL ADVISORS, LLC                                                    

By:     /s/ Peter Nussbaum                                                      
-----------------------------------                             
Name:   Peter Nussbaum                                                          
Title:  Authorized Person                                                       

S.A.C. CAPITAL MANAGEMENT, LLC                                                  

By:     /s/ Peter Nussbaum                                                      
-----------------------------------                             
Name:   Peter Nussbaum                                                          
Title:  Authorized Person                                                       

CR INTRINSIC INVESTORS, LLC                                                     

By:     /s/ Peter Nussbaum                                                      
-----------------------------------                             
Name:   Peter Nussbaum                                                          
Title:  Authorized Person                                                       

STEVEN A. COHEN                                                                 

By:     /s/ Peter Nussbaum                                                      
-----------------------------------                             
Name:   Peter Nussbaum                                                          
Title:  Authorized Person                                                       

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Dates Referenced Herein and Documents Incorporated by Reference

		Referenced-On Page
This ‘SC 13G/A’ Filing	Date	First	Last	Other Filings

Filed on:	1/12/09	10		13F-HR/A, 4, SC 13G/A
	12/31/08	1	8	13F-HR, 4
	11/3/08	7
	9/30/08	7		13F-HR
				List all Filings

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Filing Submission 0000899140-09-000109 – Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)

Sac Capital Advisors LLC, et al. – ‘SC 13G/A’ on 1/12/09 re: Orexigen Therapeutics Inc

On: Monday, 1/12/09, at 5:20pm ET · Accession #: 899140-9-109 · File #: 5-83578

Previous ‘SC 13G’: ‘SC 13G/A’ on 1/12/09 · Latest ‘SC 13G’: This Filing

Amendment to Statement of Beneficial Ownership — Schedule 13GFiling Table of Contents

Document Table of Contents

Dates Referenced Herein and Documents Incorporated by Reference

Amendment to Statement of Beneficial Ownership — Schedule 13G
Filing Table of Contents