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Akzo Nobel NV ˇ 20-F ˇ For 12/31/02

Filed On 4/22/03 10:43am ET   ˇ   SEC File 0-17444   ˇ   Accession Number 1208646-3-72

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  As Of               Filer                 Filing     As/For/On Docs:Pgs              Issuer               Agent

 4/22/03  Akzo Nobel NV                     20-F       12/31/02    3:172                                    Imprima Debussy Ltd/FA

Annual Report of a Foreign Private Issuer   ˇ   Form 20-F
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 20-F        Akzo Nobel 20f                                       149    742K 
 2: EX-8        Opinion re: Tax Matters                               22     91K 
 3: EX-10       Exhibit 10a                                            1      5K 


20-F   ˇ   Akzo Nobel 20f
Document Table of Contents

Page (sequential) | (alphabetic) Top
 
11st Page
5Item 1. Identity of Directors, Senior Management and Advisors
"Item 2. Offer Statistics and Expected Timetable
"Item 3. Key Information
15Item 4. Information on the Company
17Pharma
18Coatings
"Chemicals
34Business Review and Developments at Business Units
55Item 5. Operating and Financial Review and Prospects
"Change in Accounting Principles
77Forward looking statement on 2003
78Item 6. Directors, Senior Management and Employees
87Item 7. Major Shareholders and Related Party Transactions
88Item 8. Financial Information
91Item 9. The Offer and Listing
92Item 10. Additional Information
98Item 11. Quantitative and Qualitative Disclosures about Market Risk
100Item 12. Description of Securities Other Than Equity Securities
"Item 13. Defaults, Dividend Arreages and Delinquencies
"Item 14. Material Modifications to the Rights of Security Holders and Use of Proceeds
"Item 15. Disclosure Controls and Procedures
"Item 16. Reserved
"Item 17. Financial Statements
108Akzo Nobel
146Item 19. Exhibits
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SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 20-F (Mark one) ( )REGISTRATION STATEMENT PURSUANT TO SECTION 12 (b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 or (X) ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2002 or ( )TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number 0-17444 AKZO NOBEL N.V. (Exact name of registrant as specified in its charter) THE NETHERLANDS (Jurisdiction of incorporation or organization) 76 VELPERWEG, 6824 BM ARNHEM (Address of principal executive offices) Securities registered or to be registered pursuant to Section 12 (b) of the Act: Title of each class Name of each exchange on which registered -------------------- ----------------------------------------- AMERICAN DEPOSITARY SHARES NASDAQ/NMS COMMON SHARES OF EUR 2 EACH NASDAQ/NMS* * Not for trading, but only in connection with the registration of American Depositary Shares, pursuant to the requirements of the Securities and Exchange Commission Securities registered or to be registered pursuant to Section 12 (g) of the Act: NONE Securities for which there is a reporting obligation pursuant to Section 15 (d) of the Act: NONE Indicate the number of outstanding shares of each of the issuer's classes of capital or common shares as of the close of the period covered by the annual report: COMMON SHARES, PAR VALUE EUR 2 PER SHARE 286,147,260 PRIORITY SHARES, PAR VALUE EUR 400 PER SHARE 48 Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15 (d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes X No {box} Indicate by check mark which financial statement item the registrant has elected to follow. Item 17 {box} Item 18 X
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1 Akzo Nobel N.V. TABLE OF CONTENTS [Enlarge/Download Table] Page PART I Introduction 3 Item 1 Identity of directors, senior management and advisors 4 Item 2 Offer statistics and expected timetable 4 Item 3 Key information 4 Item 4 Information on the company 14 Item 5 Operating and financial review and prospects 54 Item 6 Directors, senior management and employees 77 Item 7 Major shareholders and related party transactions 86 Item 8 Financial information 87 Item 9 The offer and listing 90 Item 10 Additional information 91 Item 11 Quantitative and qualitative disclosure about market risk 97 Item 12 Description of securities other than equity securities 99 PART II Item 13 Defaults, dividend arreages and delinquencies 99 Item 14 Material modifications to the rights of security holders and use of proceeds 99 Item 15 Disclosure Controls and Procedures 99 Item 16 Reserved 99 PART III Item 17 Financial statements 99 Item 18 Financial statements 100 Item 19 Exhibits 145 Signatures and Certifications 146
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3 PART I INTRODUCTION The consolidated financial statements of Akzo Nobel N.V. and subsidiaries appearing in this annual report are prepared in accordance with accounting principles generally accepted in the Netherlands ("NL GAAP"). NL GAAP differ in certain respects from accounting principles generally accepted in the United States ("US GAAP"). The significant differences between NL GAAP and US GAAP affecting Akzo Nobel's net income and shareholder's equity are discussed in Note 21 of the Notes to the Consolidated Financial Statements of Akzo Nobel. The terms "Akzo Nobel" or "the Company" are sometimes used herein for convenience in contexts where reference is made to the consolidated companies of Akzo Nobel N.V. in general. Such terms are also used for convenience in referring to individual groups and subsidiaries. In this annual report, unless otherwise specified or the context otherwise requires, references to "dollars", "U.S. dollars" and "USD" are to the United States currency. For convenience only (except where noted otherwise), certain euro figures have been translated into dollars at the rate of EUR 0.955 = USD 1.00, the noon buying rate in The City of New York for cable transfers in foreign currencies as announced by the Federal Reserve Bank of New York for customs purposes (the "Noon Buying Rate") on December 31, 2002. These translations should not be construed as a representation that the euro amounts actually represent such dollar amounts or could be converted into dollars at the rate indicated. On April 17, 2003, the Noon Buying Rate was EUR 0.9156 = USD 1.00. In order to utilize the "Safe Harbor" provisions of the United States Private Securities Litigation Reform Act of 1995, Akzo Nobel is providing the following cautionary statement. This document contains certain forward-looking statements with respect to the financial condition, results of operations and business of Akzo Nobel and certain of the plans and objectives of Akzo Nobel with respect to these items. These statements may generally, but not always, be identified by the use of words such as "anticipate", "assume", "intend", "plan", "project", "should", "expect", "estimate", "believe" or similar expressions. In particular, among other statements, certain statements in Item 4 "Information on the Company" with regard to strategy, management objectives, including return on investment targets, market trends, market standing, market share estimates based on management's estimates, the product volumes, (future spending on) environmental compliance or remediation, Health, Safety and Environment targets, and the Pharma pipeline, and the statements in Item 8 "Financial Information" with regard to the outcome of disputes with tax authorities, pending or future legal or regulatory proceedings, including the antitrust investigations and other potential related lawsuits and their effect on the Company and those in Item 5 "Operating and Financial Review and Prospects" with regard to trends in results of operations, margins, overall market trends, risk management, exchange rates and objectives such as return on capital are forward-looking in nature as are all statements under "Forward looking statement on 2003" and Item 11 "Quantitative and Qualitative Disclosures about Market Risk". By their nature, forward-looking statements involve risk and uncertainty because they relate to events and depend on circumstances that will occur in the future. There are a number of factors that could cause actual results and developments to differ materially from those expressed or implied by these forward looking statements. These factors include, but are not limited to, levels of business spending in major economies (as well as other developments in the economies of the
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4 Company's markets in Asia, Latin America, North America and Western Europe), the development in market value of pension plan assets, governmental regulations, changes in customer needs, the levels of marketing expenditures by Akzo Nobel and its competitors, the introduction of new products by competitors, raw materials and employee costs, future foreign exchange and interest rates, changes in tax rates and product regulation, future business combinations, acquisitions or dispositions, environmental liabilities, and the outcome of tax disputes, antitrust investigations and potential product liability claims and other lawsuits, and wars and acts of terrorism or sabotage. Statements made in Item 4 "Information on the Company", referring to Akzo Nobel's competitive position are based on the Company's belief, and in some cases rely on a range of sources, including analyst's reports, independent market studies and Akzo Nobel's internal assessment of market share based on publicly available information about the financial results and performance of market participants unless otherwise noted. Such references to the Company's positioning generally refer to its market share based on sales. Item 1. IDENTITY OF DIRECTORS, SENIOR MANAGEMENT AND ADVISORS Not applicable. Item 2. OFFER STATISTICS AND EXPECTED TIMETABLE Not applicable. Item 3. KEY INFORMATION A. SELECTED CONSOLIDATED FINANCIAL INFORMATION The selected financial data set forth on the following pages are derived from previously published financial information of Akzo Nobel, including the consolidated financial statements, which appear elsewhere in this annual report and which have been translated into euros using the exchange rate fixed for Netherlands guilders and the euro on January 1, 1999. The selected financial data should be read in conjunction with, and are qualified in their entirety by reference to, such financial statements, including the notes thereto. The audited consolidated financial statements of Akzo Nobel as of and for each of the five years in the period ended December 31, 2002, have been audited by KPMG Accountants N.V., independent auditors. Reference is made to Note 21 of the Notes to the Consolidated Financial Statements regarding differences between NL GAAP and US GAAP that affected Akzo Nobel's net income and shareholders' equity.
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5 [Enlarge/Download Table] ---------------------------------------------------------------------------------------------------------------------- Selected financial data for the years ended December 31, In millions, except per share amounts 2002 2002 2001 2000 1999 1998 ---------------------------------------------------------------------------------------------------------------------- USD(a) EUR EUR EUR EUR EUR Consolidated Income data: Amounts in accordance with NL GAAP:* Net sales 14,662 14,002 14,110 14,003 14,432 12,482 Operating income before nonrecurring items (b) 1,562 1,492 1,571 1,641 1,238 1,147 Operating income, after nonrecurring items (b) 1,426 1,362 1,122 1,557 1,197 982 Income before nonrecurring and extraordinary items, less income taxes 971 927 966 999 722 677 Extraordinary items less income taxes (c) (77) (74) (259) (9) (508) (129) Net income after nonrecurring and extraordinary items 857 818 671 947 189 532 Basic earnings per share / ADS (d) 3.00 2.86 2.35 3.31 0.66 1.86 Amounts in accordance with US GAAP (e): Net income / (loss) 901 860 448 745 (627) 391 Basic earnings / (loss) per share / ADS (d) 3.15 3.01 1.57 2.61 (2.20) 1.37 Diluted earnings / (loss) per share / ADS (d) 3.14 3.00 1.56 2.60 (2.20) 1.37 Consolidated Balance Sheet data: Amounts in accordance with NL GAAP*: Total assets 13,392 12,789 12,925 12,707 12,643 12,528 Long-term borrowings 2,160 2,063 1,941 2,137 2,459 2,490 Shareholders' equity 2,197 2,098 2,878 2,694 2,082 2,101 Shareholders' equity in accordance with US GAAP: 5,712 5,455 6,362 6,368 5,987 6,254 ---------------------------------------------------------------------------------------------------------------------- (a) - (e): see accompanying notes on next page * Prior years have been restated for changes in accounting principles. Reference is made to "Item 5. Operating and Financial Review and Prospects - Changes in Accounting Principles".
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6 (a) Amounts in this column have been translated solely for the convenience of the reader at the Noon Buying Rate on December 31, 2002, of EUR 0.955 = USD 1.00. (b) Nonrecurring items relate to income and expenses resulting from normal business operations, which, because of their size or nature, are disclosed separately to give a better understanding of the underlying result for the period. These include items such as restructuring and impairment charges, and significant gains and losses on the disposal of businesses, not meeting the requirements for extraordinary items. (c) The extraordinary items for NL GAAP would not be considered extraordinary under US GAAP. The pre-tax effect of such items would have been included as part of operating income for US GAAP. (d) American Depositary Shares. (e) Earnings per share amounts under US GAAP are calculated after deducting priority and preferred dividends from earnings. The table below sets forth the number of common shares outstanding and the amounts of interim, final and total dividends declared (and the U.S.-dollar equivalents) on the common shares in respect of the fiscal years indicated. [Download Table] ------------------------------------------------------------------------------------ Number of shares Dividends per common share Year ended EUR USD* December 31, Average End of period Interim Final Total Interim Final Total ------------------------------------------------------------------------------------ 1998 285,296,603 285,320,200 0.30 0.68 0.98 0.34 0.79 1.14 1999 285,441,344 285,885,524 0.30 0.70 1.00 0.30 0.70 1.00 2000 285,902,574 285,937,700 0.30 0.90 1.20 0.28 0.84 1.11 2001 285,888,385 285,854,813 0.30 0.90 1.20 0.26 0.79 1.06 2002 285,827,092 285,691,957 0.30 0.90 1.20 0.32 0.94 1.26 ------------------------------------------------------------------------------------ * Dividends per common share in U.S. dollars are based on the Noon Buying Rate at December 31 of each year. The following table sets forth for the fiscal periods indicated the average exchange rates for U.S. dollars into euros per dollar based on the applicable Noon Buying Rate. The 1998 figure has been converted into euros using the fixed conversion rate, which became effective on January 1, 1999 (EUR 1 = NLG 2.20371). [Download Table] ------------------------------------------ Year ended Average* December 31, ------------------------------------------ 1998 0.90 1999 0.94 2000 1.08 2001 1.14 2002 0.96 ------------------------------------------ * The average of the Noon Buying Rates on the last day of each month during the period.
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7 The following table sets forth for the months indicated the high and low rates for U.S. dollars expressed in euros per dollar. [Download Table] --------------------------------------------- High Low October 2002 1.03 1.01 November 2002 1.08 0.98 December 2002 1.01 0.95 January 2003 0.97 0.92 February 2003 0.94 0.91 March 2003 0.95 0.90 --------------------------------------------- On April 17, 2003, the noon buying Rate was EUR 0.9156 = USD 1.00. As dividends, if any, will be paid in euros, exchange rate fluctuations may affect the USD amounts received by holders of ADS's upon conversion by the depositary of such dividends. B. CAPITALIZATION AND INDEBTEDNESS Not applicable. C. REASONS FOR THE OFFER AND USE OF PROCEEDS Not applicable. D. RISK FACTORS This section describes some of the risks that could affect the Company's business. The factors below should be considered in connection with any forward-looking statements in the Company's Annual Report on Form 20-F and the cautionary statements contained in the introduction on pages 3 and 4. Forward looking statements can be identified generally as those containing words such as "anticipate", "assume", "intend", "plan", "project", "should", "expect", "estimate", "believe", and words and terms of similar substance in connection with any discussion of future operating or financial performance. The risks below are not the only ones that Akzo Nobel faces. Some risks are not yet known to Akzo Nobel and some that Akzo Nobel does not currently believe to be material could later turn out to be material. All of these risks could materially affect Akzo Nobel's businesses, revenues, operating income, net income, net assets and liquidity and capital resources. The factors that could cause actual results to differ materially include the following: The Company may face intense competition from new products and from lower-cost generic products. The Company's products that are under patent protection face competition from competitors' proprietary products. This competition may increase as new products enter the market. The Company faces increasing competition from lower- cost generic products after patents on its products expire. Loss of patent protection typically leads to loss of sales in the product's markets and could affect the Company's future results.
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8 In 2002, the Company lost an important court case on its major product Remeron(R) in the United States. This will lead to increased competition in the United States from generic pharmaceutical companies who will produce and distribute generic versions of this product. U.S. revenues from Remeron(R) accounted for approximately 11 percent of revenues from Akzo Nobel's Pharma business in the financial year 2002. As new products enter the market, the Company's products may become obsolete or competitors' products may be more effective or more effectively marketed and sold than its own products. If Akzo Nobel fails to maintain its competitive position, this could have a material adverse effect on its business and results of operations. The Company's research and development efforts may not succeed or its competitors may develop more effective or successful products. In order to remain competitive, the Company must commit substantial resources each year to research and development through its dedicated resources as well as through various collaborations with third parties. Ongoing investments in new product launches and research and development for future products could produce higher costs without a proportional increase in revenues. Especially in the Pharma businesses, the research and development process can take from six to fourteen years, from discovery to commercial product launch. This process is conducted in various stages, and during each stage there is a substantial risk that the Company will not achieve its goals and accordingly may abandon a product for which it has spent substantial amounts. In this context it should be noted that the 2001 report prepared for the European Commission, entitled "Global Competitiveness in Pharmaceuticals, a European Perspective," concluded that European pharmaceutical companies have not only been losing competitiveness to their U.S. peers, but also that this trend has intensified. Unlike the U.S.-based multinationals, the European pharmaceutical companies still lack the background and leverage of a single domestic (European) market. The report also concluded that Europe has been less effective than the United States in encouraging growth of new technology suppliers and innovation specialists in such fields as combinatorial chemistry, genomics, and high- throughput screening. If the Company fails to continue developing commercially successful products, this could have a material adverse effect on the Company's business and results of operations. If its competitors develop more effective products or a greater number of successful new products, or if the competitive position of its European operations changes in a negative way, this could also have a material adverse effect on the Company's business and results of operations. So far, the introduction of two new FDA-approved Organon products, Arixtra(R) and NuvaRing(R), in the US market have taken off slower than expected. It can also be the case that due to unwanted side effects of pharmaceutical products, in particular, which appear at a later stage after introduction of a product, the Company may decide or may be forced to withdraw a certain product from the market. This also could have a material adverse affect on its business and results of operation. Product regulation may adversely affect the Company's ability to bring new products to market. The Company and its competitors are subject to strict government controls on the development, manufacture, labeling, distribution and marketing of products. The Company must obtain and maintain regulatory approval for its pharmaceutical and other products from regulatory agencies before certain products may be sold in a particular jurisdiction. The submission of an application to a regulatory authority does not guarantee that a license to market the product will be granted. Each authority may impose its own requirements and delay or refuse to grant approval, even though a product has been approved by another country. In the Company's principal markets, the approval process for a new product is complex, lengthy
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9 and expensive. For pharmaceutical products, the time taken to obtain approval varies by country but generally takes from eight months to several years from the date of application. Regulatory delays, the inability to complete clinical trials successfully, claims and concerns about safety and efficacy, new discoveries, patents and products of competitors and related patent disputes and claims about adverse side effects are only a few of the factors that could adversely affect the realization of product registration. This increases the Company's cost in developing new products and increases the risk that it will not succeed in selling them successfully. In this respect, the Company's planned introduction of the new CNS product Variza(TM) (gepirone ER) was delayed as it did not yet receive FDA approval. In light of the current uncertainties in the Hormone replacement therapy (HRT) area, a delay of the FDA filing of Xyvion(TM) into 2006 is to be expected. Akzo Nobel's business will continue to expose it to risks of environmental liabilities The Company uses hazardous materials, chemicals, viruses and toxic compounds in its product development programs and manufacturing processes, which have exposed it, and in the future could expose it, to risks of accidental contamination and events of noncompliance with environmental laws and regulatory enforcement, and personal injury and property damage claims resulting therefrom. If an accident occurred or if the Company were to discover contamination caused by prior operations, it could be liable for cleanup obligations, damages or fines, which could have an adverse effect on its business and results of operations. The environmental laws of many jurisdictions impose actual and potential obligations on the Company to remediate contaminated sites. These obligations may relate to sites: - that the Company currently owns or operates; - that the Company formerly owned or operated; or - where waste from the Company's operations was disposed. These environmental remediation obligations could significantly reduce the Company's operating results. In particular, the provisions and accruals for these obligations may be insufficient if the assumptions underlying the accruals prove incorrect or if the Company is held responsible for additional, currently undiscovered contamination. Stricter environmental, safety and health laws and enforcement policies could result in substantial costs and increase potential liabilities of the Company, and could subject the Company's handling, manufacture, use, reuse or disposal of substances or pollutants to more rigorous scrutiny than is currently the case. Consequently, compliance with these laws could result in significant capital expenditures as well as other costs and liabilities, thereby harming Akzo Nobel's business and operating results. The Company will be responsible for any liabilities arising out of antitrust litigation. Akzo Nobel is involved in investigations by the antitrust authorities in the United States, Canada, and the European Union into alleged violations of the respective antitrust laws for certain products in these jurisdictions. In addition, the Company is involved in civil damage claims in relation to some of these alleged antitrust violations. Fines, civil damage settlements, and legal costs incurred in 2002 in connection with these cases amounted to EUR 9 million (2001: EUR 59 million). Based on an estimate of the probable fines, civil damages, and costs to be paid over a number of years to come - taking into account legal advice and the current facts and circumstances - the Company had a provision and accrual at December 31, 2002, amounting to EUR 102 million (2001: EUR 111 million).
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10 However, it should be understood, that in light of future developments such as (a) the outcome of the investigations of the various antitrust authorities, (b) potential additional lawsuits by (indirect) purchasers, (c) possible future civil settlements, (d) the failure to satisfy the conditions of any future class action settlement, and (e) adverse rulings or judgments in the pending investigations or in related civil suits, these antitrust matters could result in additional liabilities and related costs. The Company at this point in time cannot estimate any additional amount of loss or range of loss in excess of the recorded amounts with sufficient certainty to allow such amount or range of amounts to be meaningful. Moreover, the aforementioned liabilities are typically paid over a number of years and the timing of such payments cannot be predicted with confidence. The Company believes that the potential aggregate amount of any additional fines and civil damages to be paid will not materially affect the Company's financial position. The aggregate amount, however, could be material to the Company's results of operations in any one accounting period. The outcome of tax disputes, litigation and regulatory action could adversely affect Akzo Nobel's business and results of operations. The Company brought claims against certain generic drug manufacturers in the United States under the U.S. Hatch-Waxman Act, alleging infringement by such manufacturers of the Company's U.S. patent protecting the use of mirtazapine (Remeron(R)) in combination with one or more SSRI's for the treatment of depression. In two of the patent infringement cases brought by the Company, the Court granted summary judgment of noninfringement in favor of the defendants. In light of recent new case law in an unrelated case providing guidance regarding inducement to infringe issue under the Hatch-Waxman Act, the Company has decided not to pursue further any actions and to withdraw all pending cases based on infringement of the above reference patent against the generic drug manufacturers. Some generic drug manufacturers sued by the Company have brought antitrust counterclaims against the Company in the United States. In addition, antitrust claims have been filed against the Company in the United States on behalf of classes of (in)direct purchasers of Remeron(R). The Company is aggressively defending these claims. There are pending against Akzo Nobel N.V. and its subsidiaries a number of other claims, all of which the Company is contesting. The Company is also involved in disputes with tax authorities in several jurisdictions. While the outcome of these claims and disputes cannot be predicted with certainty, management believes, based upon legal advice and information received, that the final outcome will not materially affect the consolidated financial position but could be material to the Company's result of operations in any one accounting period. Risks in production processes can adversely affect the Company's results of operations. Certain chemical production processes are hazardous, and natural disasters, operator error or other occurrences could result in explosions, fires, or equipment failure, which could result in injury or death, or damage to property or the environment. Losses and liabilities arising from such events, in so far as not covered by insurance, would significantly reduce the Company's revenues or increase costs and could have a material adverse effect on its operations or financial condition.
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11 Inability to access raw materials, growth in cost and expenses for raw materials, petroleum and natural gas and changes in product mix may adversely influence the future results of the Company. Important raw materials or auxiliary materials for the Company's production processes are salt, petroleum and petroleum derivatives, natural gas, titanium dioxide and electricity. Some of these components are available only from a small source of suppliers. The Company cannot assure that it will be able to establish or maintain good relationships with such suppliers or that such suppliers will continue to exist or be able to supply ingredients in conformity with regulatory requirements. In addition, growth in the costs and expenses of these components resulting from a shortage or a change in Akzo Nobel's product mix may adversely influence the Company's business and financial results. Akzo Nobel is sensitive to price movements in raw materials. In particular, energy prices pose a risk, presently aggravated by the armed conflict in the Middle East. Seasonality may adversely affect the operating results of the Company's Coatings business. A portion of the Company's Coatings business is seasonal, with sales and earnings being relatively higher during the outdoor season and lower during the indoor season. The operating results may be harmed if bad weather delays the outdoor season in the major markets in which the Company operates and the Company is not able to offset during the corresponding financial year the lag in earnings resulting from such delay. A failure to manage expansion effectively could adversely affect the Company's business. Management of the Company's growth, as well as the commencement of commercial manufacturing and marketing of the Company's forthcoming products, will require continued expansion of the Company's systems and internal controls and an increase in the Company's manufacturing, marketing and sales operations. In addition, the Company intends to continue to add new personnel. Any failure to manage growth effectively and integrate new personnel on a timely basis could adversely affect the Company's business. Akzo Nobel may not be able to identify future acquisitions or may not be successful in integrating acquired businesses. As part of its business strategy, the Company periodically reviews acquisition prospects and strategic alliances that it expects to complement its existing businesses or increase its revenues. The Company does not know if it will be able to identify any future acquisitions, joint ventures or alliances. A failure to identify future transactions may impair the Company's future growth. If the Company is unable to retain key personnel or attract new personnel, it could have an adverse effect on the Company's business. The Company's future operating results depend in part upon its ability to attract and retain qualified management, scientific, technical, marketing, and support personnel. Competition for such personnel is intense, and there can be no assurance that the Company will be able to continue to attract and retain such personnel. Regulations which limit the prices we may charge for our products can reduce the Company's revenues and adversely affect its business and results of operations.
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12 In addition to normal price competition in the marketplace, the prices of Akzo Nobel's pharmaceutical products are restricted by price controls imposed by governments and health care providers in most countries. Price controls operate differently in different countries and can cause wide variations in prices between markets. Currency fluctuations can aggravate these differences. The existence of price controls can limit the revenues Akzo Nobel earns from its products and may have an adverse effect on its business and results of operations. About half of the Company's earnings are derived from the healthcare markets. In many of these countries the prices for our products are regulated. In the United States, Medicare reform could result in de facto price controls on prescription drugs. In Europe, the Company's operations are also subject to price and market regulations. Many governments are introducing healthcare reforms in an attempt to curb increasing healthcare costs. In Japan, where Akzo Nobel also operates, governmental price cut rounds are introduced biannually. In response to rising healthcare costs, many governments and private medical care providers, such as HMOs, have instituted reimbursement schemes that favor the substitution of generic pharmaceuticals for more expensive brand-name pharmaceuticals. In the United States, generic substitution statutes have been enacted by virtually all states and permit or require the dispensing pharmacist to substitute a less expensive generic drug instead of the original brand-name drug. As a result, the Company expects pressures on its pricing and operating results to continue. Bad publicity and damage to the Company's brands could adversely affect its business and results of operations. The reputation of the Company's brands is critical to its business. The success in promoting and enhancing its brands is dependent on providing safe high- quality products, particularly in the pharma business. If it fails to successfully promote its brands, or if it receives bad publicity as a result of a product liability case or publicized health or other risks associated with its products, the value of the Company's brands will be diminished. This could have a material and adverse effect on the business and results of operations. Product liability claims could adversely affect Akzo Nobel's business and results of operations. Given the widespread impact that brand-name drugs have on the health of patient populations, pharmaceutical and medical devices companies have historically been subject to large product-liability claims and settlements caused by the use of their products. The Company also runs the risk of product liability claims from its Coatings and Chemicals products. The Company is currently involved in a number of product liability cases claiming damages as a result of its products. It believes that any reasonably foreseeable unaccrued costs and liabilities associated with such matters will not have a material adverse effect on the Company's consolidated financial position but could be materially adverse to its results of operations. There can, however, be no assurance that a future product liability claim or series of claims that are not fully covered by insurance would not have an adverse effect on the Company's business or results of operations. Exchange rate fluctuations can have a harmful impact on the Company's financial results. The Company has operations in more than 80 countries throughout the world. As a result, a substantial portion of its assets, liabilities, revenues and expenses are denominated in various currencies other than the euro, principally the U.S. dollar, the British pound, the Swedish krona, the Japanese yen, and Latin American and Asian currencies. Because the Company's financial statements are denominated in euro, fluctuations in currency exchange rates could have a material impact on its reported results.
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13 The Company's financial condition and results of operations could be adversely affected if the Company does not successfully mitigate risks associated with interest rate changes. A substantial portion of the Company's investments, loans and borrowings bear interest on a non-fixed basis. Accordingly, changes in interest rates can affect the cost of these interest-bearing investments, loans and borrowings. The Company mitigates interest risk by financing noncurrent assets and a certain portion of current assets with equity, long-term liabilities and long- term borrowings with fixed interest rates. In the event that this strategy is not successful, the business, financial condition and operating results of the Company could be materially and adversely affected as a result of changes in interest rates. Adverse stock market developments may affect assets of pension funds, causing higher pension charges and pension premiums payable. The Company has a number of defined benefit pension plans, covering the majority of its employees. Plan assets principally consist of long-term interest-earning investments, quoted equity securities, and real estate. The performance of stock markets could have a material impact on the Company's financial statements as some 40 percent of plan assets are equity securities. The poor performance of the stock markets in 2001 and 2002 had a negative influence on the investment results of Akzo Nobel's pension funds, resulting in additional pension charges, pension premiums and payments to such funds. The pension charges in 2002 were EUR 80 million higher than in 2001, while pension charges for 2003 will be EUR 130 million higher than in 2002. Furthermore, the Company recognized an additional minimum unfunded pension liability of approximately EUR 1.8 billion (pre-tax), at December 31, 2002 A downgrading by credit rating agencies could result in higher financing costs or reduced availability of credit At present the Company's long-term credit rating form Standard & Poor's is A- with a short-term rating of A-2. The current long-term credit rating from Moody's is A3 and their short-term rating is P-2. All ratings mentioned have a so-called "negative outlook" to them. The present rating is 3 notches above the so-called high-yield zone. However, if the Company's rating, due to whatever circumstances would approach or enter the high-yield zone, this will not only result in increased financing cost for the Company, but could also reduce availability of credit, especially at commercially acceptable rates. A security rating is not a recommendation to buy, sell or hold securities. The rating may be subject to revision or withdrawal at any time by the rating organization. Each rating should be valued independently of any other rating. Because the Company conducts international operations, it is exposed to a variety of risks, many of them beyond its control, that could adversely affect its business. Akzo Nobel is a global company with operations in Europe, North America, Latin America, Asia, the Middle East and Africa. In addition to general business risk and the risks described in this section, the Company's international operations are subject to a variety of potential risks including: political and economic instability, the risk of hyperinflation in some countries, currency and interest-rate fluctuations, lack of local business experience, difficulty in enforcing property rights, local security concerns, and language and other cultural barriers. In addition, changes in the tax laws of some countries where the Company does business can affect the Company's net income.
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14 Item 4. INFORMATION ON THE COMPANY Akzo Nobel is a corporation organized under the law of the Netherlands for an indefinite period. The principal executive offices of Akzo Nobel N.V. are located at Velperweg 76, 6824 BM Arnhem, the Netherlands. Its telephone number is +31 (26) 366 4433 and the fax number is +31 (26) 366 3250. The E-mail address is ACC@akzonobel.com. Any correspondence regarding this Annual Report on Form 20-F should be directed to the Company Secretary. The name and address of the person authorized to receive notices and communications from the U.S. Securities and Exchange Commission is: A. Jan A.J. Eijsbouts, General Counsel Akzo Nobel N.V. Velperweg 76, 6824 BM Arnhem The Netherlands Copies to: Edwin D. Williamson, Esq. Sullivan & Cromwell LLP 1701 Pennsylvania Avenue, N.W. Washington, D.C. 20006 202-956 7505 OVERVIEW Akzo Nobel is an international company that serves customers around the world with healthcare products, coatings, and chemicals. Headquartered in the Netherlands, Akzo Nobel had activities in more than 80 countries and employed 67,000 people during 2002. Sales in 2002 were EUR 14.0 billion, with Pharma, Coatings, and Chemicals accounting for EUR 4.0 billion, EUR 5.5 billion, and EUR 4.6 billion, respectively. In the pharmaceutical industry, Akzo Nobel is smaller than many of its competitors, but it has significant positions in products for female reproductive therapy and anesthesiology. Akzo Nobel believes that based on sales it is the largest coatings producer in the world; its products and markets vary widely from architectural paints in some countries to industrial and automotive coatings in others. In the chemical products industry, Akzo Nobel is a significant competitive factor in a number of markets, and on a global basis the Company competes with a number of larger chemical companies. Demand for Akzo Nobel's products, particularly its chemical and coatings products, is generally reflective of the overall health of industry in Western Europe and the United States and is, except for certain Coatings activities, generally not seasonal in nature. It is Akzo Nobel's objective to develop or acquire new and defend existing leading positions in its markets, while maintaining structural long-term profitability. In addition to its core business, the Company focuses on the development of new and improved products in major growth sectors that draw on the Company's technological and marketing know-how. The Company is pursuing expansion in Eastern Europe, South-East Asia and Latin America. Where the Company cannot achieve leading positions on its own, management may seek acquisitions, alliances or divestments, thus striving for structural, long-term increases in shareholder value.
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15 A. HISTORY AND DEVELOPMENT OF THE COMPANY Akzo was created in 1969, out of the merger between AKU N.V. ("AKU") and Koninklijke Zout-Organon N.V., and in 1994 it was renamed Akzo Nobel, after the merger with Nobel Industries AB ("Nobel"). AKU N.V. was founded in 1911 under the name of N.V. Nederlandsche Kunstzijdefabriek. Over the years this company grew into an international concern with interests in the field of cellulose fibers and, following the Second World War, synthetic textile and carpet fibers as well as industrial fibers. At the time of the 1969 merger, AKU's principal countries of operation were the Netherlands, Germany, the United States, the United Kingdom, Spain and several Latin American countries, where activities were often carried out through joint ventures with local partners. Koninklijke Zout-Organon N.V. was set up in 1967 as a holding company in connection with the merger between Koninklijke Zout-Ketjen N.V. and N.V. Koninklijke Zwanenberg-Organon. Koninklijke Zout-Ketjen N.V. had interests in companies active in salt refining, basic chemicals, specialty chemicals and coatings. While these companies were mainly active in the Netherlands, they had built up major export positions at the time of the merger. N.V. Koninklijke Zwanenberg-Organon consisted of companies active in food/nonfood products and chemical products and of pharmaceutical companies producing brand-name drugs, nonprescription products and raw materials for the pharmaceutical industry. Nobel was formed in 1984 through the merger of Bofors (established in 1646) and KemaNobel, founded in 1871. At the time of the merger with Akzo in 1994, Nobel was a leading European producer of chemicals (pulp and paper chemicals and surfactants) and coatings (paints for professional and consumer markets, industrial coatings and industrial products). Nobel had operations in more than 30 countries. In July 1998, Akzo Nobel acquired Courtaulds plc ("Courtaulds"), an international chemical company with leading positions in high-tech industrial coatings and man-made fibers. Its best known brands, International Paints, Courtelle acrylic fibers, and Tencel(R), a new cellulosic fiber, were included in the acquisition. Courtaulds, which was founded in 1816 as a silk weaving company, pioneered the global man-made fiber industry at the beginning of the 20th century. In the 1960s Courtaulds acquired International Paint and Pinchin Johnson. In November 1999, the Company acquired Hoechst Roussel Vet ("HR Vet"), the veterinary business of Hoechst AG. Through this acquisition, Intervet, the veterinary business of Akzo Nobel became a significant player in the veterinary business. After the Courtaulds acquisition, the fibers operations of Akzo Nobel and Courtaulds were combined into a separate organization, named Acordis. At December 31, 1999, Acordis was sold to a newly established company. Akzo Nobel retained a 21 percent stake in this company. In June 2001, Covance Biotechnology Services Inc (CBSI), North Carolina was acquired for EUR 223 million. Through this acquisition, Diosynth established the critical mass to play a leading role in the strongly developing biopharmaceutical market segment. At the end of June 2001, the diagnostic business of Organon Teknika was divested to bioMerieux for EUR 334 million. In addition, the activities of the business unit Printing Inks were divested for EUR 75 million, effective October 31, 2001.
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16 In April 2002, the Awlgrip(R) marine and aerospace coatings business was acquired for EUR 27 million. At the end of June 2002, the Industrial Specialties business of Crompton Corporation, including operations in the United States, Europe and Asia, was acquired for EUR 96 million. At the end of September 2002, the liquid pharmaceuticals manufacturing business Rosemont Pharmaceuticals Ltd in the United Kingdom was divested for EUR 102 million, and effective September 2002, Ferro's powder coatings businesses in the Americas and Asia Pacific were acquired for EUR 70 million. B. BUSINESS OVERVIEW Akzo Nobel has a two-layer organization, with the Board of Management as the highest executive authority. Operations are carried out in business units clustered in three groups on the basis of affinity between activities: Pharma, Coatings and Chemicals. At the corporate level, key tasks are coordinated in the fields of strategy; finance and control; human resources; technology; legal affairs and intellectual property; communications; health, safety, and environment; information management; and risk and insurance management. STRATEGY Akzo Nobel is a diversified multinational group of companies. We focus on leadership positions in selected markets on the strength of our entrepreneurial spirit and Business Principles. We consider our diversity an asset, the real value of which lies in our organization philosophy of strongly decentralized operating companies, combined with optimal use of our financial power, cyclical resilience, and collective know-how. Concentrating on sustained growth, we strengthen our market positions through a targeted investment policy, complementary acquisitions and, if necessary, restructuring measures. We continuously aim at striking a proper balance between overall size and the focus on our diverse activities. We strive to maintain strong growth in Pharma, further strengthen and expand our Coatings business-the world's largest in its industry-and concentrate on improving Chemicals' returns and cash flow. Our strategy is constantly being fine-tuned to optimize value creation, while a solid balance sheet structure and sound financial ratios are maintained. Pharma Pharma aims to continue its pattern of primarily organic growth, based on its strong commitment to R&D and its pipeline, which has created substantial value over the years. In addition, growth momentum will be supported by intensively pursuing opportunities for collaborations and product acquisitions. Our present portfolio enables us to exploit our extensive knowledge base, capitalize on our pipelines of innovative products, and harness critical mass in selected markets. Actions Our strategy is reflected in a double-digit average annual organic growth on an ongoing basis and an equally strong earnings gain over the last five years. Under a scenario of a temporary slowdown, we strive to bolster growth through new product launches-for example Arixtra(R) and NuvaRing(R)-from our pipeline. Simultaneously, cost cutting programs to safeguard our earnings level are implemented. Organon also moved its Executive Office to the United States, its most important market. Organic growth and acquisitions in the last few years have made Intervet the world's third largest supplier of veterinary products. Diosynth
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17 strengthened its position through CBSI acquired in 2001 and invested heavily in upstream and downstream processing capacity. In 2001 and 2002, Rosemont's generics activities in the United States and the United Kingdom were divested. Pharma's long-term financial targets are a return on sales of around 20 percent and return on investment of 40 percent. Coatings Major acquisitions in the last few years, combined with organic growth, has lifted Coatings to the world's number one position. We aim to strengthen this position through further organic growth and bolt-on acquisitions. Growth in mature markets is expected to remain in line with GDP. Opportunities are in emerging markets and in technology switches often driven by environmental considerations. In the fragmented worldwide coatings market, we, as the world leader, only represent 8 percent. This market is in a process of consolidation, in which our global positions in many fields should enable us to play a leading role. Actions In line with this strategy, Coatings' expansion efforts and investments in Asia resulted in improved positions and strong growth, particularly in China. The acquisitions of Ferro's powder coatings businesses in the Americas and Asia, the aerospace activities of U.S. Paint, a marine and protective coatings factory in Korea, and U.S. Paint Yacht bolstered our positions in these areas. Major restructuring programs, including some divestments and plant closures, and strong efforts to reduce working capital are geared to lift profitability. Coatings' long-term financial target is to achieve a 30 percent return on investment. Chemicals For Chemicals critical mass and leading positions in chosen segments are essential in the quite fragmented chemical industry. Our strategy is based on three cornerstones: concentrate on fewer growth areas, drive innovation, and inspire and develop our people. Our primary efforts focus on structural improvement of margins and cash flow through ongoing cost savings programs. Divestments, selective acquisitions, and generating sufficient cash flow to upgrade the portfolio are the leading principles. Growth efforts are directed at North America and Asia. Actions The acquisition of the Crompton Industrial Specialties business in the United States, Europe, and Asia and the start-up of a grassroots monochloroacetic acid plant in China represent two important steps to support Chemicals' leading positions in these areas. Base Chemicals strengthened its position in the German market by increasing its participation in ECI Elektro-Chemie from 50 percent to 100 percent. In order to improve performance and cash flow, extensive restructurings, including plant closures such as the Stade, Germany, salt plant, are being implemented, combined with a working capital reduction program. Chemicals is targeting a return over the business cycle of 2.5 percent over the cost of capital, which corresponds to a return on investment of about 17 percent.
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18 BUSINESS UNITS The business units and their products (as at December 31, 2002) are summarized below: PHARMA Organon - Brand-name prescription pharmaceuticals in the fields of contraceptives and infertility treatment, hormone replacement therapy (HRT) and osteoporosis, antidepressants and antipsychotics, antithrombotics and muscle relaxants. Intervet - Veterinary products: vaccines, antiparasitics, and antiinfectives, specialty products for pets and livestock, and feed additives for livestock, endocrinological fertility products, corticosteroids, antibiotics and anti-mastitis products. Diosynth - Complex active pharmaceutical ingredients based on chemicals and biochemical processes and generic medicines. COATINGS Decorative Coatings - Coatings for decoration and protection of architectural structures for professional uses and the do-it-yourself sector. Industrial Coatings* - Liquid coatings for industrial application; aerospace coatings Industrial Finishes - Coatings for industrial applications on wood and sheet metal (coil coatings) Powder Coatings - Powder coatings for industrial application in architectural automotive, domestic appliance and other industrial markets such as coatings for pipes. Marine & Protective Coatings - Antifouling and other high-performance coatings for the shipbuilding, ship repair and yacht markets; protective coatings and fire- retardant products for heavy-duty applications, such as on oilrigs. Car Refinishes - Products and services for the automotive aftersales market and for commercial vehicles. Industrial Products - Industrial adhesives, resin-impregnated paper, and expandable microspheres. * As per January 1, 2003, the business unit Industrial Coatings has been dissolved. Aerospace activities have been transferred to Marine & Protective Coatings. Transportation Coatings were transferred to Car Refinishes.
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19 CHEMICALS Pulp and Paper Chemicals - Pulp bleaching chemicals, notably sodium chlorate and hydrogen peroxide; wet-end paper chemicals, such as sizing and retention agents and wet strength resins. Functional Chemicals - Monochloroacetic acid and derivatives, such as carboxymethyl cellulose; methyl amines, choline chloride; ethylene amines; chelates; organophosphorus-based derivatives, notably flame-retardants for plastics and hydraulic fluids; carbon disulfide and thiocyanates; acid chlorides and lubrican chemicals. Surface Chemistry - Cationic, nonionic, and anionic surfactants for detergents, biocides, wood preservation, personal care, and industrial cleaners; cellulosic surfactants for paint and concrete; asphalt additives, viscose agents, animal feed additives and fatty acids. Polymer Chemicals - Initiators such as organic peroxides, metal alkyls, and Ziegler-Natta catalysts for the production of polymers, optical monomers and polymer additives. Resins - Synthetic resins for coatings and printing inks. Catalysts - Refinery catalysts, technology and related services; catalysts for the petrochemical industry and custom-made catalysts. Base Chemicals - Electrolysis products: notably chlorine, hydrochloric acid, methylen chloride, chloroform. Other products: sulphur products and dimethylether. Salt - High quality salts for food processing, consumer, agriculture, water softening, pharmaceuticals, electrolysis, de-icing and other industries. Energy - Supply of energy (cogeneration) and other utilities. ACTIVITIES OF AKZO NOBEL Industry segment information Prior years have been restated for changes in accounting principles. Reference is made to "Item 5. Operating and Financial Review and Prospects - Changes in Accounting Principles". Nonrecurring items relate to income and expenses resulting from normal business operations, which, because of their size or nature, are disclosed separately to give a better understanding of the underlying result for the period. These include items such as restructuring and impairment charges, and significant gains and losses on the disposal of businesses, not meeting the requirements for extraordinary items.
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20 Akzo Nobel's financial reporting and industry segment information consists of results from the following groups: "Pharma", "Coatings" and "Chemicals". The information presented below illustrates the relative importance of the individual groups. [Enlarge/Download Table] ----------------------------------------------------------------------------------------------------------------------------------- Net sales Operating income before nonrecurring* items Millions of euros 2002 2001 2000 2002 2001 2000 ----------------------------------------------------------------------------------------------------------------------------------- Pharma 4,008 4,044 3,839 768 831 765 Coatings 5,521 5,591 5,568 465 426 447 Chemicals 4,598 4,604 4,740 344 340 445 Miscellaneous products, intragroup deliveries, non-allocated items and eliminations (125) (129) (144) (85) (26) (16) ----------------------------------------------------------------------------------------------------------------------------------- Total 14,002 14,110 14,003 1,492 1,571 1,641 ----------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------- * Nonrecurring items relate to income and expenses resulting from normal business operations, which, because of their size or nature, are disclosed separately to give a better understanding of the underlying result for the period. These include items such as restructuring and impairment charges, and significant gains and losses on the disposal of businesses, not meeting the requirements for extraordinary items. [Enlarge/Download Table] ----------------------------------------------------------------------------------------------------------------------------------- Nonrecurring* items Operating income, after nonrecurring* items Millions of euros 2002 2001 2000 2002 2001 2000 ----------------------------------------------------------------------------------------------------------------------------------- Pharma 21 41 (2) 747 790 767 Coatings 19 200 13 446 226 434 Chemicals 96 218 77 248 122 368 Miscellaneous products, intragroup deliveries, non-allocated items and eliminations (6) (10) (4) (79) (16) (12) ----------------------------------------------------------------------------------------------------------------------------------- Total 130 449 84 1,362 1,122 1,557 ----------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------- * Nonrecurring items relate to income and expenses resulting from normal business operations, which, because of their size or nature, are disclosed separately to give a better understanding of the underlying result for the period. These include items such as restructuring and impairment charges, and significant gains and losses on the disposal of businesses, not meeting the requirements for extraordinary items. [Enlarge/Download Table] ----------------------------------------------------------------------------------------------------------------------------------- Property, plant and equipment Identifiable assets Expenditures Depreciation Millions of euros 2002 2001 2000 2002 2001 2000 2002 2001 2000 ----------------------------------------------------------------------------------------------------------------------------------- Pharma 3,195 3,333 2,964 297 317 214 152 148 146 Coatings 3,338 3,372 3,381 131 181 170 150 156 149 Chemicals 3,557 3,837 3,953 248 310 329 311 320 323 Miscellaneous products, nonallocated and eliminations, including cash and cash equivalents 2,208 1,808 1,736 13 14 12 9 11 13 ----------------------------------------------------------------------------------------------------------------------------------- 12,298 12,350 12,034 689 822 725 622 635 631 Nonconsolidated comp. 491 575 673 ----------------------------------------------------------------------------------------------------------------------------------- Total 12,789 12,925 12,707 689 822 725 622 635 631 ----------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------
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21 [Enlarge/Download Table] Percent (%) of total net sales and total operating income -------------------------------------------------------------------------------------------------------- Net sales Operating income Operating income before nonrecurring* after nonrecurring* items items 2002 2001 2000 2002 2001 2000 2002 2001 2000 -------------------------------------------------------------------------------------------------------- Pharma 29 29 27 51 53 47 55 70 49 Coatings 39 39 40 31 27 27 33 20 28 Chemicals 33 33 34 23 22 27 18 11 24 Miscellaneous products and nonallocated (1) (1) (1) (5) (2) (1) (6) (1) (1) -------------------------------------------------------------------------------------------------------- Total 100 100 100 100 100 100 100 100 100 -------------------------------------------------------------------------------------------------------- * Nonrecurring items relate to income and expenses resulting from normal business operations, which, because of their size or nature, are disclosed separately to give a better understanding of the underlying result for the period. These include items such as restructuring and impairment charges, and significant gains and losses on the disposal of businesses, not meeting the requirements for extraordinary items. Below a summary of the activities of each group is given. For more details on Akzo Nobel's activities, reference is made to "Business Review and Developments at Business Units". See Item 5 "Operating and Financial Review and Prospects" for a discussion on factors affecting comparability between periods. Description of Pharma's business Akzo Nobel's healthcare activities extend around the world. It engages in research, development, manufacturing, sales, and service in strategic areas of human and animal healthcare. These include prescription medicines, veterinary products, as well as complex active pharmaceutical ingredients. [Enlarge/Download Table] Major Product Lines Key Products/Applications Competitive Position* Prescription drugs, - Contraceptives, infertility treatment, - Among top four suppliers of hormonal veterinary products, and hormone replacement thereapy (HRT) contraceptives, second largest in complex active pharmaceutical and ostoporosis, CNS produts infertility products; among top five ingredients. (antidepressants, antipsychotics), players in HRT; building up positions antithrombotics, and muscle relaxants in CNS and osteoporosis. World leader in neuromuscular relaxation; entering the antithrombosis segment - Veterinary vaccines, and pharmaceuticals - The third- largest world supplier of veterinary products; leading in veterinary vaccines - Complex active pharmaceutical - Leading supplier of steroids and ingredients synthetic peptides, strong in heparins, oligosaccharides, and biopharmaceuticals * See the cautionary statements under introduction on pages 3 and 4. Akzo Nobel's business unit Organon has an international reputation based on quality products and innovative R&D. It is among a very few international companies conducting research into contraception.
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22 Sold as Desogen(R) in the United States, Marvelon(R) is one of the world's most prescribed contraceptive pills. However, sales of our oral contraceptives have been adversely affected by generic competition in the United States. NuvaRing(R), our contraceptive vaginal ring, was launched in the United States and Europe in 2002. The Company also produces fertility products and medicines for the treatment of menopausal complaints and, as innovator in the field of psychiatric drugs, is marketing a new-generation antidepressant (Remeron(R)). However, in December 2002 an unfavorable court ruling in the Remeron(R) case paved the way for our competitors to produce and distribute in the United States generic versions of this important Organon product. Together with Sanofi-Synthelabo, the Company developed the new antithrombotic (pentasaccharide) Arixtra(R), which has been approved and launched in the U.S. and Europe. Arixtra(R) is currently approved for the prevention of thrombosis following hip and joint surgery. The process of hospital formulary approval for the introduction of Arixtra in the United States is time consuming. In March 2003, the FDA granted a six-month priority review for a supplemental new drug application for Arixtra(R) for Prophylaxis of deep venous thrombosis, which may lead to pulmonary embolism, in patients undergoing hip fracture surgery, including extended prophylaxis. In the United States, additional data requests by the FDA regarding Variza(TM) (Gepirone ER) has delayed its registration. Intervet focuses on the veterinary medicine market, with vaccines for cattle, pigs, sheep, horses, poultry, fish and pets, endocrine fertility products, corticosteroids and antibiotics, including injectors for treating mastitis and metritis. The acquisition of Hoechst Roussel Vet, in November 1999, complemented the product range with specialty medical products for both pets and livestock, and feed additives for livestock. Intervet has an international reputation and works closely with leading research institutes, universities, and other companies. In 2003, a new vaccine production facility near Kansas City is expected to be opened. Diosynth is a leading manufacturer of complex active pharmaceutical ingredients, with production facilities in several countries. The company is active in biochemical extraction and purification, fermentation, industrial cell culture, and organic synthesis. Diosynth's main products are heparin, insulin, gonadotropic hormones, steroids, synthetic peptides, carbohydrates, and opiate analogs. Through the acquisition of CBSI, the Company believes that Diosynth now has sufficient size and products to play a leading role in the developing biopharmaceutical market segment. In 2002, we also decided to enter the human vaccine business because it is a growth market and because we can benefit from our experie