As Of                Filer                Filing    For·On·As Docs:Size              Issuer               Agent

 1/12/16  Kirk Randal J                     SC 13D/A               2:233K Transgenomic Inc                  Summit Fin’l Printing
          Third Security Incentive 2010 LLC
          Third Security Senior Staff 2008 LLC
          Third Security Staff 2010 LLC
          Third Security Staff 2014 LLC
          Third Security, LLC

Document/Exhibit                   Description                      Pages   Size 

 1: SC 13D/A    Randal J. Kirk SC 13D A No 4 1-6-2016               HTML    106K 
                          (Transgenomic, Inc.)                                   
 2: EX-99.22    Exhibit 22                                          HTML      9K 

This Amendment No. 4 (this “Amendment”) amends and supplements the Statement on Schedule 13D, dated December 29, 2010 and filed on January 11, 2011, as amended by Amendment No. 1 dated February 3, 2012 and filed on February 7, 2012, as amended by Amendment No. 2 dated January 25, 2013 and filed on January 31, 2013, as amended by Amendment No. 3 dated March 5, 2014 and filed on March 7, 2014 (the “Original Schedule 13D”), relating to the Common Stock, par value $0.01 per share (the “Common Stock”), of Transgenomic, Inc., a Delaware corporation (the “Company”).  Mr. Randal J. Kirk (“Mr. Kirk”), Third Security, LLC (“Third Security”), a Virginia limited liability company that is managed by Mr. Kirk, Third Security Senior Staff 2008 LLC (“Senior Staff”), a Virginia limited liability company that is managed by Third Security, Third Security Staff 2010 LLC (“Staff 2010”), a Virginia limited liability company that is managed by Third Security, Third Security Incentive 2010 LLC (“Incentive”), a Virginia limited liability company that is managed by Third Security, and Third Security Staff 2014 LLC (“Staff 2014” and, together with Senior Staff, Staff 2010 and Incentive, the “Investors,” and the Investors together with Mr. Kirk and Third Security, the “Reporting Persons”), a Virginia limited liability company that is managed by Third Security, are filing this Amendment to disclose:  (i) the acquisition by the Investors of an aggregate of 214,705 shares of Series A-1 Convertible Preferred Stock and 161,026 warrants to purchase Common Stock in a private placement transaction on January 8, 2016; (ii) the conversion of Series A Convertible Preferred Stock and Series B Convertible Preferred Stock on January 6, 2016 into an aggregate of 2,305,354 shares of Common Stock (the “Conversion Shares”); and (iii) the acquisition on January 6, 2016 of an aggregate of 4,474,825 shares of Common Stock in lieu of a cash dividend payment associated with the Conversion Shares.

Except as set forth below, there are no changes to the information set forth in the Original Schedule 13D.

Item 3 of the Original Schedule 13D is hereby amended and supplemented by adding the following at the end thereof:

On January 6, 2016, the Company entered into a Conversion Agreement with the Investors, pursuant to which the Company and the Investors: (i) elected to convert all of the outstanding Conversion Shares into shares of Common Stock, in each case in accordance with the terms thereof, and (ii) agreed that all accrued and unpaid dividends on the Conversion Shares would be paid by the Company in shares of Common Stock at a rate of one (1) share of Common Stock per dividend dollar, which is based upon the closing price of the Common Stock on January 6, 2016. The outstanding shares of Series A Convertible Preferred Stock were convertible into shares of Common Stock at a ratio of 1-for-3, and the outstanding shares of Series B Convertible Preferred Stock were convertible into shares of Common Stock at a ratio of 1-for-1.

The foregoing references to and description of the Purchase Agreement do not purport to be complete and are subject to, and are qualified in their entirety by reference to, the full text of the Purchase Agreement, which is included as Exhibit 20 hereto and is incorporated by reference to this Item 3.

Item 4 of the Original Schedule 13D is hereby amended and supplemented as follows:

Item 5 of the Original Schedule 13D is hereby amended and restated in its entirety as follows:

The information contained on the cover pages to this Statement and the information set forth or incorporated in Items 2, 3, 4 and 6 is incorporated herein by reference.

Item 6 of the Original Schedule 13D is hereby amended and supplemented by adding the following at the end thereof:

The following is a summary of certain terms and conditions of the Registration Rights Agreement which is attached hereto as Exhibit 21.