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Pacira BioSciences, Inc. – ‘10-K’ for 12/31/12 – ‘EX-101.INS’

On:  Thursday, 3/7/13, at 2:56pm ET   ·   For:  12/31/12   ·   Accession #:  1047469-13-2336   ·   File #:  1-35060

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  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 3/07/13  Pacira BioSciences, Inc.          10-K       12/31/12   87:9M                                     Toppan Merrill-FA

Annual Report   —   Form 10-K   —   Sect. 13 / 15(d) – SEA’34
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-K        Annual Report                                       HTML    979K 
 2: EX-10.47    Material Contract                                   HTML    318K 
 3: EX-10.48    Material Contract                                   HTML    163K 
 4: EX-21.1     Subsidiaries List                                   HTML     20K 
 5: EX-23.1     Consent of Experts or Counsel                       HTML     25K 
 6: EX-31.1     Certification -- §302 - SOA'02                      HTML     28K 
 7: EX-31.2     Certification -- §302 - SOA'02                      HTML     28K 
 8: EX-32.1     Certification -- §906 - SOA'02                      HTML     24K 
 9: EX-32.2     Certification -- §906 - SOA'02                      HTML     24K 
59: R1          Document and Entity Information                     HTML     51K 
45: R2          Consolidated Balance Sheets                         HTML    144K 
57: R3          Consolidated Balance Sheets (Parenthetical)         HTML     49K 
61: R4          Consolidated Statements of Operations               HTML     90K 
80: R5          Consolidated Statements of Comprehensive Loss       HTML     48K 
48: R6          Consolidated Statements of Stockholders' Equity     HTML    135K 
                (Deficit)                                                        
56: R7          Consolidated Statements of Cash Flows               HTML    180K 
41: R8          Business                                            HTML     33K 
31: R9          Summary of Significant Accounting Policies          HTML     67K 
81: R10         Recent Accounting Pronouncements                    HTML     26K 
63: R11         Financial Instruments                               HTML     54K 
62: R12         Inventories                                         HTML     32K 
68: R13         Fixed Assets                                        HTML     38K 
69: R14         Goodwill and Intangible Assets                      HTML     55K 
66: R15         Accrued Expenses                                    HTML     31K 
70: R16         Debt                                                HTML     51K 
58: R17         Stockholders' Equity                                HTML     48K 
60: R18         Stock Plans                                         HTML     73K 
65: R19         Earnings Per Share                                  HTML     43K 
87: R20         Cost of Revenues                                    HTML     31K 
76: R21         Income Taxes                                        HTML     59K 
52: R22         Other Employee Benefits                             HTML     25K 
64: R23         Commercial Partners and Other Agreements            HTML     35K 
54: R24         Related Party Transactions                          HTML     35K 
23: R25         Commitments and Contingencies                       HTML     42K 
77: R26         Subsequent Events                                   HTML     26K 
84: R27         Summary of Significant Accounting Policies          HTML    145K 
                (Policies)                                                       
36: R28         Summary of Significant Accounting Policies          HTML     40K 
                (Tables)                                                         
35: R29         Financial Instruments (Tables)                      HTML     53K 
39: R30         Inventories (Tables)                                HTML     29K 
40: R31         Fixed Assets (Tables)                               HTML     33K 
42: R32         Goodwill and Intangible Assets (Tables)             HTML     52K 
21: R33         Accrued Expenses (Tables)                           HTML     30K 
74: R34         Debt (Tables)                                       HTML     35K 
50: R35         Stockholders' Equity (Tables)                       HTML     37K 
53: R36         Stock Plans (Tables)                                HTML     77K 
26: R37         Earnings Per Share (Tables)                         HTML     43K 
86: R38         Cost of Revenues (Tables)                           HTML     30K 
16: R39         Income Taxes (Tables)                               HTML     54K 
43: R40         Commitments and Contingencies (Tables)              HTML     29K 
79: R41         Summary of Significant Accounting Policies          HTML     29K 
                (Details)                                                        
25: R42         Summary of Significant Accounting Policies          HTML     43K 
                (Details 2)                                                      
34: R43         Summary of Significant Accounting Policies          HTML     31K 
                (Details 3)                                                      
38: R44         Financial Instruments (Details)                     HTML     26K 
46: R45         Financial Instruments (Details 2)                   HTML     47K 
20: R46         Financial Instruments (Details 3)                   HTML     31K 
30: R47         Inventories (Details)                               HTML     42K 
18: R48         Fixed Assets (Details)                              HTML     52K 
78: R49         Goodwill and Intangible Assets (Details)            HTML     44K 
24: R50         Goodwill and Intangible Assets (Details 2)          HTML     59K 
75: R51         Accrued Expenses (Details)                          HTML     36K 
27: R52         Debt (Details)                                      HTML    169K 
44: R53         Stockholders' Equity (Details)                      HTML     61K 
17: R54         Stockholders' Equity (Details 2)                    HTML     53K 
19: R55         Stock Plans (Details)                               HTML     37K 
37: R56         Stock Plans (Details 2)                             HTML     30K 
22: R57         Stock Plans (Details 3)                             HTML    117K 
82: R58         Earnings Per Share (Details)                        HTML     42K 
49: R59         Earnings Per Share (Details 2)                      HTML     33K 
67: R60         Cost of Revenues (Details)                          HTML     30K 
29: R61         Income Taxes (Details)                              HTML     79K 
32: R62         Income Taxes (Details 2)                            HTML     45K 
73: R63         Other Employee Benefits (Details)                   HTML     25K 
71: R64         Commercial Partners and Other Agreements (Details)  HTML     29K 
51: R65         Related Party Transactions (Details)                HTML     60K 
72: R66         Commitments and Contingencies (Details)             HTML     63K 
28: R67         Commitments and Contingencies (Details 2)           HTML     33K 
55: R68         Commitments and Contingencies (Details 3)           HTML     32K 
83: R69         Subsequent Events (Details)                         HTML     42K 
85: XML         IDEA XML File -- Filing Summary                      XML    125K 
33: EXCEL       IDEA Workbook of Financial Reports (.xls)            XLS    909K 
10: EX-101.INS  XBRL Instance -- pcrx-20121231                       XML   1.48M 
12: EX-101.CAL  XBRL Calculations -- pcrx-20121231_cal               XML    258K 
15: EX-101.DEF  XBRL Definitions -- pcrx-20121231_def                XML    769K 
13: EX-101.LAB  XBRL Labels -- pcrx-20121231_lab                     XML   3.14M 
14: EX-101.PRE  XBRL Presentations -- pcrx-20121231_pre              XML   1.39M 
11: EX-101.SCH  XBRL Schema -- pcrx-20121231                         XSD    250K 
47: ZIP         XBRL Zipped Folder -- 0001047469-13-002336-xbrl      Zip    232K 


‘EX-101.INS’   —   XBRL Instance — pcrx-20121231


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<us-gaap:ProceedsFromIssuanceInitialPublicOffering id="Tag212" decimals="-3" contextRef="D2011" unitRef="USD"> 38016000 </us-gaap:ProceedsFromIssuanceInitialPublicOffering>
<us-gaap:ProceedsFromIssuanceOfCommonStock id="Tag213" decimals="-3" contextRef="D2011" unitRef="USD"> 49006000 </us-gaap:ProceedsFromIssuanceOfCommonStock>
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<us-gaap:ProceedsFromConvertibleDebt id="Tag217" decimals="-3" contextRef="D2010" unitRef="USD"> 7500000 </us-gaap:ProceedsFromConvertibleDebt>
<us-gaap:ProceedsFromSecuredNotesPayable id="Tag218" decimals="-3" contextRef="D2010" unitRef="USD"> 56250000 </us-gaap:ProceedsFromSecuredNotesPayable>
<us-gaap:RepaymentsOfDebt id="Tag219" decimals="-3" contextRef="D2010" unitRef="USD"> 11250000 </us-gaap:RepaymentsOfDebt>
<us-gaap:PaymentsOfFinancingCosts id="Tag220" decimals="-3" contextRef="D2010" unitRef="USD"> 1795000 </us-gaap:PaymentsOfFinancingCosts>
<us-gaap:NetCashProvidedByUsedInFinancingActivitiesContinuingOperations id="Tag221" decimals="-3" contextRef="D2010" unitRef="USD"> 50705000 </us-gaap:NetCashProvidedByUsedInFinancingActivitiesContinuingOperations>
<us-gaap:NetCashProvidedByUsedInContinuingOperations id="Tag222" decimals="-3" contextRef="D2011" unitRef="USD"> 20035000 </us-gaap:NetCashProvidedByUsedInContinuingOperations>
<us-gaap:NetCashProvidedByUsedInContinuingOperations id="Tag223" decimals="-3" contextRef="D2010" unitRef="USD"> 19056000 </us-gaap:NetCashProvidedByUsedInContinuingOperations>
<us-gaap:InterestPaid id="Tag224" decimals="-3" contextRef="D2010" unitRef="USD"> 2371000 </us-gaap:InterestPaid>
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<us-gaap:DebtIssuanceCostsIncurredDuringNoncashOrPartialNoncashTransaction id="Tag226" decimals="-3" contextRef="D2010" unitRef="USD"> 500000 </us-gaap:DebtIssuanceCostsIncurredDuringNoncashOrPartialNoncashTransaction>
<us-gaap:InterestPaid id="Tag227" decimals="-3" contextRef="D2012" unitRef="USD"> 4229000 </us-gaap:InterestPaid>
<us-gaap:DepreciationDepletionAndAmortization id="Tag228" decimals="-3" contextRef="D2012" unitRef="USD"> 5648000 </us-gaap:DepreciationDepletionAndAmortization>
<us-gaap:CashAndCashEquivalentsAtCarryingValue id="Tag229" decimals="-3" contextRef="I2009" unitRef="USD"> 7077000 </us-gaap:CashAndCashEquivalentsAtCarryingValue>
<us-gaap:CashAndCashEquivalentsAtCarryingValue id="Tag230" decimals="-3" contextRef="I2010" unitRef="USD"> 26133000 </us-gaap:CashAndCashEquivalentsAtCarryingValue>
<us-gaap:CashAndCashEquivalentsAtCarryingValue id="Tag231" decimals="-3" contextRef="I2012" unitRef="USD"> 10126000 </us-gaap:CashAndCashEquivalentsAtCarryingValue>
<us-gaap:OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock id="Tag232" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b>NOTE 1—BUSINESS</b></font></p> <p style="FONT-FAMILY: times"><font size="2">        Pacira Pharmaceuticals, Inc. and its subsidiaries (collectively, the "Company" or "Pacira") is an emerging specialty pharmaceutical company focused on the development, commercialization and manufacture of proprietary pharmaceutical products, based on its proprietary DepoFoam extended release drug delivery technology, for use in hospitals and ambulatory surgery centers. The Company's lead product EXPAREL, which consists of bupivacaine encapsulated in DepoFoam, was approved by the FDA on October 28, 2011 and launched commercially in April 2012. DepoFoam is also the basis for the Company's other FDA-approved product, DepoCyt(e), which the Company manufactures for commercial partners, and DepoDur, which the Company is no longer marketing.</font></p> <p style="FONT-FAMILY: times"><font size="2">        Pacira Pharmaceuticals, Inc. is the holding company for its California operating subsidiary of the same name, also referred to as PPI-California, which was acquired from SkyePharma Holding, Inc., or Skyepharma, in March 2007, or the Acquisition.</font></p> <p style="FONT-FAMILY: times"><font size="2"><b><i>Risks and Uncertainties</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company is subject to risks common to companies in similar industries and stages of development, including, but not limited to, competition from larger companies, reliance on revenue from few customers and products, reliance on single manufacturing sites, new technological innovations, dependence on key personnel, reliance on third-party service providers and sole source suppliers, protection of proprietary technology and compliance with government regulations.</font></p></div>
</us-gaap:OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock>
<us-gaap:SignificantAccountingPoliciesTextBlock id="Tag233" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b>NOTE 2—SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES</b></font></p> <p style="FONT-FAMILY: times"><font size="2"><b><i>Basis of Presentation and Principles of Consolidation</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        The consolidated financial statements have been prepared in accordance with generally accepted accounting principles in the United States of America, or GAAP, and in accordance with the rules and regulations of the Securities and Exchange Commission, or SEC. The accounts of wholly owned subsidiaries are included in the consolidated financial statements. All intercompany balances and transactions have been eliminated in consolidation. Certain reclassifications were made to conform to the current presentation. Specifically, the Company reclassified DepoCyt(e) and DepoDur supply sales for the years ended December 31, 2011 and 2010 to net product sales to conform to the current presentation. This reclassification had no impact on net loss or stockholders' equity as previously reported.</font></p> <p style="FONT-FAMILY: times"><font size="2"><b><i>Use of Estimates</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        The preparation of financial statements in conformity with GAAP requires the use of estimates and assumptions that affect the reported amounts of assets and liabilities, including disclosure of contingent assets and contingent liabilities, at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Estimates are used for, among other things, the valuation of assets acquired, impairment of long-lived assets, goodwill, stock-based compensation and valuation of deferred tax assets. The Company's critical accounting policies are those that are both most important to the Company's consolidated financial condition and results of operations and require the most difficult, subjective or complex judgments on the part of management in their application, often as a result of the need to make estimates about the effect of matters that are inherently uncertain. Because of the uncertainty of factors surrounding the estimates or judgments used in the preparation of the consolidated financial statements, actual results could differ from these estimates.</font></p> <p style="FONT-FAMILY: times"><font size="2"><b><i>Liquidity</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        Management believes that the Company's existing cash and cash equivalents, short-term investments, including the proceeds from its private offering of $120.0 million in convertible senior notes completed in January 2013, and revenue from product sales will be sufficient to enable the Company to meet its planned operating expenses, capital expenditure requirements and service its indebtedness at least through December 31, 2013. However, changing circumstances may cause the Company to expend cash significantly faster than currently anticipated, and the Company may need to spend more cash than currently expected because of circumstances beyond its control. The Company expects to continue to incur substantial additional operating losses as it commercializes EXPAREL and develops and seeks regulatory approval for its product candidates.</font></p> <p style="FONT-FAMILY: times"><font size="2"><b><i>Revenue Recognition</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Product Sales</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company sells EXPAREL primarily to wholesalers based on orders of the product from hospitals and other end user customers such as ambulatory surgery centers and doctors. The Company recognizes revenue when there is persuasive evidence that an arrangement exists, title has passed, collection is reasonably assured and the price is fixed or determinable. Sales to wholesalers provide for selling prices that are fixed on the date of sale. EXPAREL is delivered directly to the end user with the wholesaler never taking physical possession of the product. The Company records revenue at the time the product is delivered to the end user. The Company also recognizes revenue from products manufactured and supplied to commercial partners. Prior to the shipment of the manufactured products such as DepoCyt(e), the Company conducts initial product release and stability testing in accordance with current Good Manufacturing Practices, or cGMP.</font></p> <p style="FONT-FAMILY: times"><font size="2">        At the time the Company recognizes revenue, it also records certain sales reserves and allowances as a reduction of revenue. These reserves and allowances include a prompt payment reserve, return reserves, volume rebates, chargeback reserve and wholesaler service fee. Due to estimates and assumptions inherent in determining some of the sales reserves, the actual amount of volume rebates, chargebacks and returns may be different from estimates, at which time the Company would adjust the reserves accordingly.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Prompt Pay Reserve</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        The prompt payment reserve is based upon discounts offered to wholesalers as an incentive to meet certain payment terms. The Company accounts for these discounts at the time the sale is made and reduces accounts receivable accordingly.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Return Reserves</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company allows customers to return product that is damaged or received in error. In addition, the Company allows for EXPAREL product to be returned beginning six months prior to, and twelve months following product expiration. As EXPAREL is a new commercially available product, the Company is estimating its sales return reserve based on return history from other hospital-based products with similar distribution models, which management believes is the best estimate of the anticipated product to be returned. The returns reserve is recorded at the time of sale as a reduction to sales and an increase in returns liability.</font></p> <p style="FONT-FAMILY: times"><font size="2">        Commercial partners can return the products within contracted specified timeframes if the products do not meet the applicable inspection tests. Historically, returns from commercial partners have not been material.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Volume Rebates and Chargeback Reserve</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        Volume rebates and chargeback reserve are based upon contracted discounts and promotional offers the Company provides to certain end users, including hospitals and ambulatory surgery centers such as members of group purchasing organizations. The volume rebates and chargeback reserve are recorded as a reduction to sales and a customer payable and reduction to receivables, respectively.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Wholesaler Service Fee</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company's customers include major and regional wholesalers with whom the Company has contracted a fee for service based on a percentage of sales. This fee for service is recorded as a reduction to gross sales and a liability is established at the time the sale is recorded based on the contracted percentage.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Allowance for Doubtful Accounts</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company evaluates its accounts receivable to determine if a provision for an allowance for doubtful accounts is appropriate. The Company's sales to date are primarily to established customers. As of December 31, 2012 and 2011, the accounts receivable was considered collectible and no allowance for doubtful accounts was recorded.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Royalty Revenue</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company recognizes revenue from royalties based on sales of its products by commercial partners. Royalties are recognized as earned in accordance with contract terms when they can be estimated based on historical product sales, royalty receipts and other relevant information and collectability is reasonably assured.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Collaborative Licensing and Development Revenue</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company recognizes revenue from reimbursements received in connection with feasibility studies and development work for third parties who desire to utilize its DepoFoam extended release drug delivery technology for their products when the Company's contractual services are performed, provided collectability is reasonably assured. The Company's principal costs under these agreements include its personnel conducting research and development and allocated overhead, as well as research and development performed by outside contractors or consultants.</font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company recognizes revenues from non-refundable up-front license fees received ratably over the performance period using the estimated development period in development agreements and the contract period or longest patent life in supply and distribution agreements. If the estimated performance period is subsequently modified, the Company will modify the period over which the up-front license fee is recognized accordingly on a prospective basis. Upon notification of a termination of a collaboration agreement, any remaining non-refundable license fees received by the Company, which had been deferred, are recognized over the remaining contractual term. If the termination is immediate and no additional services are to be performed, the deferred revenue is generally recognized in full. All such recognized revenues are included in collaborative licensing and development revenue in the Company's consolidated statements of operations.</font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company recognizes revenue from milestone payments received under collaboration agreements when earned, provided that the milestone event is substantive, its achievability was not reasonably assured at the inception of the agreement, the Company has no further performance obligations relating to the event, and collectability is reasonably assured. If these criteria are not met, the Company recognizes milestone payments ratably over the remaining period of the Company's performance obligations under the collaboration agreement. All such recognized revenues are included in collaborative licensing and development revenue in the Company's consolidated statements of operations.</font></p> <p style="FONT-FAMILY: times"><font size="2"><b><i>Concentration of Major Customers</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company's customers are its major and regional wholesalers and commercial and collaborative and licensing partners. The Company is dependent on its commercial partners to market and sell DepoCyt(e). The table below includes the percentage of revenue comprised by the three largest customers in each year presented.</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="100%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="64"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="64"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="64"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="8"><font size="1"><b>Year Ended</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br /> 2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br /> 2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br /> 2010</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Largest customer</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">30</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">43</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">49</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Second largest customer</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">14</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">23</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">21</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Third largest customer</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">11</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">19</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">13</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"> </p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">55</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">85</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">83</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div> <p style="FONT-FAMILY: times"><font size="2">        Sales to customers outside the U.S. accounted for 23%, 64% and 52% of the Company's revenue for the years ended December 31, 2012, 2011 and 2010, respectively.</font></p> <p style="FONT-FAMILY: times"><font size="2"><b><i>Research and Development Expenses</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        Research and development expenses consist of costs associated with products being developed internally, and include related personnel expenses, laboratory supplies, active pharmaceutical ingredients, manufacturing supplies, facilities costs, preclinical and clinical trial costs, and other outside service fees. The Company expenses research and development costs as incurred. A significant portion of the Company's development activities are outsourced to third parties, including contract research organizations. In such cases, the Company may be required to estimate related service fees to be accrued.</font></p> <p style="FONT-FAMILY: times"><font size="2"><b><i>Cash and Cash Equivalents</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        All highly-liquid investments with maturities of 90 days or less when purchased are considered cash equivalents.</font></p> <p style="FONT-FAMILY: times"><font size="2"><b><i>Restricted Cash</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        As further discussed in Note 9,</font> <font size="2"><i>Debt</i></font><font size="2">, the Company has entered into a financing agreement with Royalty Securitization Trust I ("RST") for the sale of a royalty interest in its DepoCyt(e) and DepoDur product revenue and royalties. As part of this financing agreement, the Company and RST maintain a lockbox, where all DepoCyt(e) and DepoDur product revenue and royalties are received. The Company has no minimum payment obligations under this agreement. Commencing on April 1 of every year, the first $2.5 million received in the lockbox is restricted and is used to make quarterly payments due to RST, if any, under the agreement during the subsequent 12 month period. On March 31 of the subsequent year, the balance of cash in the lockbox, if any, is remitted to the Company. The RST agreement terminates on December 31, 2014. The royalty interest agreement pertains only to DepoCyt(e) and DepoDur, and does not include revenue related to EXPAREL or any other product candidates.</font></p> <p style="FONT-FAMILY: times"><font size="2"><b><i>Short-Term Investments</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company determines the appropriate classification of its investments at the time of purchase and reevaluates such determination at each balance sheet date. The Company's investment policy sets minimum credit quality criteria and maximum maturity limits on its investments to provide for preservation of capital, liquidity and a reasonable rate of return. Available-for-sale securities are recorded at fair value, based on current market valuations. Unrealized holding gains and losses on available-for-sale securities are excluded from net loss and are reported as a separate component of other comprehensive income (loss) until realized. Realized gains and losses are included in non-operating other income (expense) on the consolidated statement of operations and are derived using the specific identification method for determining the cost of the securities sold.</font></p> <p style="FONT-FAMILY: times"><font size="2"><b><i>Inventories</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        Inventories consist of finished goods held for sale and distribution, raw materials and work in process, and are stated at the lower of cost, which includes amounts related to material, labor and overhead, or market (net realizable) value and is determined using the first-in, first-out ("FIFO") method. The Company periodically reviews its inventory to identify obsolete, slow-moving or otherwise unsalable inventories, and establishes allowances for situations in which the cost of the inventory is not expected to be recovered. Overhead costs associated with excess manufacturing capacity are charged to cost of revenue, as incurred.</font></p> <p style="FONT-FAMILY: times"><font size="2"><b><i>Fixed Assets</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        Fixed assets are recorded at cost, net of accumulated depreciation and amortization. The Company reviews its property, plant and equipment assets for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset may not be recoverable.</font></p> <p style="FONT-FAMILY: times"><font size="2">        Depreciation of fixed assets is provided over their estimated useful lives on a straight-line basis. Leasehold improvements are amortized on a straight-line basis over the shorter of their estimated useful lives or the related lease terms. Useful lives by asset category are as follows:</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="100%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="left" width="75"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" nowrap="nowrap" align="left"> <div style="MARGIN-BOTTOM: 0pt; WIDTH: 53pt; BORDER-BOTTOM: #000000 1pt solid"><font size="1"><b>Asset Category <!-- COMMAND=ADD_SCROPPEDRULE,53pt --></b></font></div></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center"><font size="1"><b>Years</b></font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Manufacturing and laboratory equipment</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">5 to 10 years</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Computer equipment and software</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">1 to 3 years</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Office furniture and equipment</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">5 years</font></td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div> <p style="FONT-FAMILY: times"><font size="2"><b><i>Goodwill and Intangible Assets</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        Intangible assets are recorded at cost, net of accumulated amortization. Amortization of intangible assets is provided over their estimated useful lives on a straight-line basis. The Company evaluates the recoverability of intangible assets periodically and takes into account events and circumstances which indicate that impairment exists. Goodwill represents the excess of purchase price over fair value acquired in a business combination and is not amortized, but subject to impairment at least annually or when a triggering event occurs that could indicate a potential impairment.</font></p> <p style="FONT-FAMILY: times"><font size="2"><b><i>Impairment of Long-Lived Assets</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        Management reviews long-lived assets, including fixed assets, for impairment whenever events or changes in circumstances indicate the carrying amount of an asset may not be recoverable. Recoverability of assets to be held and used is measured by a comparison of the carrying amount of an asset to future undiscounted net cash flows expected to be generated by the asset. If such assets are considered to be impaired, the impairment to be recognized is measured as the amount by which the carrying amount of the assets exceeds the fair value of the assets.</font></p> <p style="FONT-FAMILY: times"><font size="2"><b><i>Foreign Currencies</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company receives payment from certain of its commercial partners relating to royalties on DepoCyte in Euros. Realized gains and losses from foreign currency transactions are reflected in the consolidated statements of operations and were not significant in any period. All foreign currency receivables and payables are measured at the applicable exchange rate at the end of the reporting period.</font></p> <p style="FONT-FAMILY: times"><font size="2"><b><i>Income Taxes</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company uses the asset and liability method of accounting for income taxes. Deferred tax assets and liabilities are recognized for the estimated future tax consequences attributable to differences between the financial statement carrying amounts of existing assets and liabilities and their respective tax bases. Deferred tax assets and liabilities are measured using enacted tax rates expected to apply to taxable income in the years in which those temporary differences are expected to be recovered or settled. Valuation allowances are established when necessary to reduce deferred tax assets to the amount expected to be realized. As of December 31, 2012 and 2011, all deferred tax assets were fully offset by a valuation allowance.</font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company accrues interest and penalties, if any, on underpayment of income taxes related to unrecognized tax benefits as a component of income tax expense in its consolidated statements of operations.</font></p> <p style="FONT-FAMILY: times"><font size="2"><b><i>Per Share Data</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        Basic net loss per share is computed by dividing net loss available (attributable) to common stockholders by the weighted average number of shares of common stock outstanding during the period. Because the holders of the Series A convertible preferred stock were not contractually required to share in the Company's losses, in applying the two-class method to compute basic net loss per common share no allocation to preferred stock was made for the years ended December 31, 2011 and 2010. At December 31, 2012, there were no Series A convertible preferred stock outstanding as a result of the initial public offering on February 8, 2011 when all convertible preferred stock was converted into common stock.</font></p> <p style="FONT-FAMILY: times"><font size="2">        Diluted net income (loss) per share is calculated by dividing net income available (attributable) to common stockholders as adjusted for the effect of dilutive securities, if any, by the weighted average number of common stock and dilutive common stock outstanding during the period. Potential common shares include the shares of common stock issuable upon the exercise of outstanding stock options and warrants (using the treasury stock method). Potential common shares in the diluted net loss per share computation are excluded to the extent that they would be anti-dilutive. No potentially dilutive securities are included in the computation of any diluted per share amounts as the Company reported a net loss for all periods presented.</font></p> <p style="FONT-FAMILY: times"><font size="2"><b><i>Stock-Based Compensation</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company's stock-based compensation programs include grants of stock options to employees, consultants and non-employee directors. The expense associated with these programs is recognized in the Company's consolidated statements of operations based on their fair values as they are earned under the applicable vesting terms.</font></p> <p style="FONT-FAMILY: times"><font size="2">        The valuation of stock options is an inherently subjective process, since market values are generally not available for long-term, non-transferable stock options. Accordingly, the Company uses an option pricing model to derive an estimated fair value. In calculating the estimated fair value of stock options granted, the Company uses the Black-Scholes option pricing model which requires the consideration of the following variables for purposes of estimating fair value:</font></p> <ul> <li style="list-style: none"> <dl compact="compact"> <dt style="MARGIN-BOTTOM: -11pt; FONT-FAMILY: times"><font size="2"></font></dt> <dd style="FONT-FAMILY: times"><font size="2">Expected term of the option</font> <font size="2"><br /> <br /></font></dd> <dt style="MARGIN-BOTTOM: -11pt; FONT-FAMILY: times"><font size="2"></font></dt> <dd style="FONT-FAMILY: times"><font size="2">Expected volatility</font> <font size="2"><br /> <br /></font></dd> <dt style="MARGIN-BOTTOM: -11pt; FONT-FAMILY: times"><font size="2"></font></dt> <dd style="FONT-FAMILY: times"><font size="2">Expected dividends</font> <font size="2"><br /> <br /></font></dd> <dt style="MARGIN-BOTTOM: -11pt; FONT-FAMILY: times"><font size="2"></font></dt> <dd style="FONT-FAMILY: times"><font size="2">Risk-free interest rate</font><br /> <br /> <br /> <p style="FONT-FAMILY: times"><font size="2">        Because the Company's common stock was not publicly held prior to February 2011, the expected volatility was based on the historic volatility for publicly traded industry peers for shares granted prior to the initial public offering. Since its initial public offering, the Company utilizes its available historic volatility data combined with the publicly traded peer's historic volatility to determine expected volatility over the expected option term. The Company's limited historical stock option exercise experience does not provide a reasonable basis upon which to estimate expected term. Accordingly, the Company uses a term based on a simplified method, pursuant to SEC Staff Accounting Bulletin No. 107, Share-based Payment, for "plain vanilla" options. The risk-free interest rate is based on the implied yield on U.S. Department of the Treasury zero coupon bonds for periods commensurate with the expected term of the options. The dividend yield on the Company's common stock is estimated to be zero as the Company has not paid any dividends since inception. The Company estimates the level of award forfeitures expected to occur, and records compensation cost only for those awards that are ultimately expected to vest.</font></p></dd></dl></li></ul> <p style="FONT-FAMILY: times"><font size="2"><b><i>Segment Reporting</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company operates in one reportable segment and, accordingly, no segment disclosures have been presented.</font></p></div>
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<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b>NOTE 3—RECENT ACCOUNTING PRONOUNCEMENTS</b></font></p> <p style="FONT-FAMILY: times"><font size="2">        In February 2013, the Financial Accounting Standards Board, or FASB, issued amendments to the accounting guidance for presentation of comprehensive income to improve the reporting of reclassifications out of accumulated other comprehensive income. The amendments do not change the current requirements for reporting net income or other comprehensive income, but do require an entity to provide information about the amounts reclassified out of accumulated other comprehensive income by component. In addition, an entity is required to present, either on the face of the statement where the net income is presented or in the notes, significant amounts reclassified out of accumulated other comprehensive income by the respective line items of net income but only if the amount reclassified is required under GAAP to be reclassified to net income in its entirety in the same reporting period. For other amounts that are not required under GAAP to be reclassified in their entirety to net income, an entity is required to cross-reference to other disclosures required under GAAP that provide additional detail about these amounts. These amendments are effective prospectively for reporting periods beginning after December 15, 2012. The Company does not believe the adoption of this guidance will have a material impact on the consolidated financial statements.</font></p> <p style="FONT-FAMILY: times"><font size="2">        Other pronouncements issued by the FASB or other authoritative accounting standards groups with future effective dates are either not applicable or not significant to the consolidated financial statements of the Company.</font></p></div>
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<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b>NOTE 4—FINANCIAL INSTRUMENTS</b></font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Fair Value Measurements</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        Fair value is defined as the price that would be received to sell an asset or paid to transfer a liability in the principal or most advantageous market in an orderly transaction. To increase consistency and comparability in fair value measurements, FASB established a three-level hierarchy, which requires an entity to maximize the use of observable inputs and minimize the use of unobservable inputs when measuring fair value. The three levels are:</font></p> <ul> <li style="list-style: none"> <dl compact="compact"> <dt style="MARGIN-BOTTOM: -11pt; FONT-FAMILY: times"><font size="2"></font></dt> <dd style="FONT-FAMILY: times"><font size="2"><i>Level 1:</i></font><font size="2">  Quoted prices (unadjusted) in active markets that are accessible at the measurement date for assets or liabilities. The fair value hierarchy gives the highest priority to Level 1 inputs.</font> <font size="2"><br /> <br /></font></dd> <dt style="MARGIN-BOTTOM: -11pt; FONT-FAMILY: times"><font size="2"></font></dt> <dd style="FONT-FAMILY: times"><font size="2"><i>Level 2:</i></font><font size="2">  Observable prices that are based on inputs not quoted on active markets, but corroborated by market data.</font> <font size="2"><br /> <br /></font></dd> <dt style="MARGIN-BOTTOM: -11pt; FONT-FAMILY: times"><font size="2"></font></dt> <dd style="FONT-FAMILY: times"><font size="2"><i>Level 3:</i></font><font size="2">  Unobservable inputs that are used when little or no market data is available. The fair value hierarchy gives the lowest priority to Level 3 inputs.</font></dd></dl></li></ul> <p style="FONT-FAMILY: times"><font size="2">        The fair value of the long-term debt at December 31, 2012 is calculated using a discounted cash flow analysis factoring in current market borrowing rates for similar types of borrowing arrangements under a similar credit profile. The carrying amount and fair value of the Company's long-term debt is for disclosure purposes only (in thousands):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 10%; WIDTH: 80%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="100%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="18"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="36"></td> <td style="FONT-FAMILY: times" width="18"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="18"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="36"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="2"> </font></th> <th style="FONT-FAMILY: times" align="left" colspan="2"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times" rowspan="2"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="8" rowspan="2"><font size="1"><b>Fair Value Measurements Using</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times" rowspan="2"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2" rowspan="2"><font size="1"><b>Carrying<br /> Value</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" nowrap="nowrap" align="left"> <div style="MARGIN-BOTTOM: 0pt; WIDTH: 166pt; BORDER-BOTTOM: #000000 1pt solid"><font size="1"><b>Financial Liabilities Carried at Historical Cost <!-- COMMAND=ADD_SCROPPEDRULE,166pt --></b></font></div></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Level 1</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Level 2</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Level 3</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2"><b>December 31, 2012</b></font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Long term debt—current and long-term</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">27,500</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">28,497</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div> <p style="FONT-FAMILY: times"><font size="2">        Short-term investments consist of U.S. Treasury securities, investment grade commercial paper, asset-backed securities collateralized by credit card receivables and corporate bonds with initial maturities of greater than three months at the date of purchase but less than one year. The net unrealized gains (losses) from the Company's short-term investments are captured in other comprehensive income (loss). At December 31, 2012, all of the Company's short-term investments are classified as available for sale investments and determined to be Level 2 instruments, which are measured at fair value using standard industry models with observable inputs. At December 31, 2012, the Company had $30.9 million invested in short-term investments which were rated A or better by Standard & Poor's and had maturities ranging from 210 to 356 days from date of purchase.</font></p> <p style="FONT-FAMILY: times"><font size="2">        The following summarizes the Company's short-term investments at December 31, 2012 and 2011 (in thousands):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="100%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="51"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="51"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="49"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" nowrap="nowrap" align="left"> <div style="MARGIN-BOTTOM: 0pt; WIDTH: 64pt; BORDER-BOTTOM: #000000 1pt solid"><font size="1"><b>December 31, 2012 <!-- COMMAND=ADD_SCROPPEDRULE,64pt --></b></font></div></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Cost</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Gross<br /> Unrealized<br /> Gains</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Gross<br /> Unrealized<br /> Losses</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Fair Value<br /> (Level 2)</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Debt securities:</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Commercial Paper</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">15,974</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">23</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">15,997</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Corporate Bonds</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">8,874</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(1</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">8,874</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Asset-backed Securities</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">6,049</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">4</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">6,053</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">30,897</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">28</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(1</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">30,924</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div> <p style="FONT-FAMILY: times"><font size="2"> <br /></font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="100%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="51"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="51"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="49"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" nowrap="nowrap" align="left"> <div style="MARGIN-BOTTOM: 0pt; WIDTH: 64pt; BORDER-BOTTOM: #000000 1pt solid"><font size="1"><b>December 31, 2011 <!-- COMMAND=ADD_SCROPPEDRULE,64pt --></b></font></div></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Cost</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Gross<br /> Unrealized<br /> Gains</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Gross<br /> Unrealized<br /> Losses</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Fair Value<br /> (Level 2)</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Debt securities:</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">US Treasury Securities</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,000</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,000</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Commercial Paper</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">11,476</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">23</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">11,499</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Corporate Bonds</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">17,494</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(10</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">17,486</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">29,970</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">25</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(10</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">29,985</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div> <p style="FONT-FAMILY: times"><font size="2">        Certain assets and liabilities are measured at fair value on a nonrecurring basis including assets and liabilities acquired in a business combination, equity-method investments and long-lived assets, which would be recognized at fair value if deemed to be impaired or if reclassified as assets held for sale. The fair value in these instances would be determined using Level 3 inputs.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Credit Risk</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        Financial instruments which potentially subject the Company to concentrations of credit risk consist primarily of cash and cash equivalents, short-term investments and accounts receivable. The Company maintains its cash and cash equivalents and short-term investments with high-credit quality financial institutions. At times, such amounts may exceed Federally insured limits. The Company performs ongoing credit evaluations of its customers, as warranted, and generally does not require collateral. As of December 31, 2012, four customers accounted for over 10% of the Company's accounts receivable; 31%, 27%, 16% and 15%. At December 31, 2011, two customers accounted for 56% and 41% of the Company's accounts receivable. Revenues are primarily derived from major wholesalers and pharmaceutical companies that generally have significant cash resources. Allowances for doubtful accounts receivable are maintained based on historical payment patterns, aging of accounts receivable and actual write-off history. As of December 31, 2012 and 2011, no allowances for doubtful accounts were deemed necessary by the Company on its accounts receivable.</font></p></div>
</us-gaap:FinancialInstrumentsDisclosureTextBlock>
<us-gaap:EarningsPerShareTextBlock id="Tag236" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b>NOTE 12—EARNINGS PER SHARE</b></font></p> <p style="FONT-FAMILY: times"><font size="2">        Basic earnings per share is calculated by dividing the net loss attributable by the weighted average number of shares outstanding during the period, without consideration for common stock equivalents. Diluted earnings per share is calculated by dividing the net loss attributable by the weighted average number of shares outstanding plus common stock equivalents computed using the treasury stock method. For purposes of this calculation, convertible preferred stock, stock options and warrants are considered to be common stock equivalents and are only included in the calculation of diluted net loss per share when their effect is dilutive. The following table sets forth the computation of basic and diluted loss per share for the years ended December 31, 2012, 2011 and 2010 (in thousands except per share amounts):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="100%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="64"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="64"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="64"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="8"><font size="1"><b>Year Ended</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br /> 2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br /> 2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br /> 2010</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2"><b>Numerator:</b></font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="white"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Net loss</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(52,281</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(43,328</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(27,149</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2"><b>Denominator:</b></font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="white"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Weighted average shares of common stock outstanding</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">30,332</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">16,437</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">574</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2"><b>Net loss per share</b></font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="white"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Basic and diluted net loss per share of common stock</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(1.72</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(2.64</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(47.29</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div> <p style="FONT-FAMILY: times"><font size="2">        The preferred stock, convertible debt, stock options and warrants are excluded from the calculation of diluted loss per share because the net loss for the years ended December 31, 2012, 2011 and 2010, causes such securities to be anti-dilutive. The potential dilutive effect of these securities is shown in the chart below (in thousands):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="100%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="64"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="64"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="64"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="8"><font size="1"><b>Year Ended</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br /> 2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br /> 2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br /> 2010</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Convertible series A preferred stock</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">6,323</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Stock options</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,276</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,177</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,058</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Convertible debt</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,425</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Warrants</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">161</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">110</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">80</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,437</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,287</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">8,886</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
</us-gaap:EarningsPerShareTextBlock>
<us-gaap:InventoryDisclosureTextBlock id="Tag237" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b>NOTE 5—INVENTORIES</b></font></p> <p style="FONT-FAMILY: times"><font size="2">        The components of inventories were as follows (in thousands):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="100%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="39"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="5"><font size="1"><b>December 31,</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Raw materials</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">4,081</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">862</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Work-in-process</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,979</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">96</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Finished goods</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,017</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">287</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">12,077</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,245</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div> <p style="FONT-FAMILY: times"><font size="2">        For the year ended December 31, 2012, the Company recorded a $0.3 million write down of DepoCyt(e) finished inventory related to the amount of excess product that may not be marketable under the remediation plan committed to the Medicines and Healthcare products Regulatory Agency, or MHRA. See Note 18,</font> <font size="2"><i>Commitments and Contingencies</i></font><font size="2">, for further discussion. For the year ended December 31, 2011, the Company recorded a $0.2 million write down of DepoDur inventory.</font></p></div>
</us-gaap:InventoryDisclosureTextBlock>
<us-gaap:PropertyPlantAndEquipmentDisclosureTextBlock id="Tag238" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b>NOTE 6—FIXED ASSETS</b></font></p> <p style="FONT-FAMILY: times"><font size="2">        Fixed assets, at cost, summarized by major category, consist of the following (in thousands):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="100%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="50"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="5"><font size="1"><b>December 31,</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Machinery and laboratory equipment</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">12,414</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">12,188</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Computer equipment and software</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,579</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,133</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Office furniture and equipment</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">437</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">352</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Leasehold improvements</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">6,217</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">6,056</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Construction in progress</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">30,072</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">13,656</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">50,719</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">33,385</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Less accumulated depreciation</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(11,603</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(8,282</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 30pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Fixed assets, net</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">39,116</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">25,103</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div> <p style="FONT-FAMILY: times"><font size="2">        Depreciation expense for the years ended December 31, 2012, 2011 and 2010 was $3.6 million, $2.0 million and $1.8 million, respectively. During the years ended December 31, 2012 and 2011, the Company capitalized interest of $2.0 million and $0.8 million, respectively, on the construction of its manufacturing site. Capitalized interest was not material and, therefore, not capitalized for the year ended December 31, 2010, due to non-routine delays in the construction of the manufacturing site.</font></p> <p style="FONT-FAMILY: times"><font size="2">        During the year ended December 31, 2011, an impairment loss of $1.3 million was recognized due to a decision made during the fourth quarter of 2011 to change the automation technology process in the Company's production line to expand EXPAREL capacity resulting in certain software and equipment previously capitalized as construction in progress that were no longer utilizable. Also during 2011, the Company impaired $0.3 million of DepoDur-related equipment. Refer to Note 7,</font> <font size="2"><i>Goodwill and Intangible Assets</i></font><font size="2">, for discussion on the impairment. These impairment losses are reflected in impairment of long-lived assets in the Company's consolidated statements of operations.</font></p></div>
</us-gaap:PropertyPlantAndEquipmentDisclosureTextBlock>
<us-gaap:IntangibleAssetsDisclosureTextBlock id="Tag239" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b>NOTE 7—GOODWILL AND INTANGIBLE ASSETS</b></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company's goodwill arose from the triggering in April 2012 of a contingent milestone payment to Skyepharma in connection with the Acquisition. The Acquisition was accounted for under Statement of Financial Accounting Standards 141,</font> <font size="2"><i>Accounting for Business Combinations</i></font><font size="2">, which was the effective GAAP at the Acquisition date. In connection with the Acquisition, the Company agreed to certain earn-out payments based on a percentage of net sales of EXPAREL collected and certain other yet-to-be-developed products, as well as milestone payments for EXPAREL as follows:</font></p> <ul> <li style="list-style: none"> <dl compact="compact"> <dt style="MARGIN-BOTTOM: -11pt; FONT-FAMILY: times"><font size="2">(a)</font></dt> <dd style="FONT-FAMILY: times"><font size="2">$10.0 million upon first commercial sale in the United States;<br /> <br /></font></dd> <dt style="MARGIN-BOTTOM: -11pt; FONT-FAMILY: times"><font size="2">(b)</font></dt> <dd style="FONT-FAMILY: times"><font size="2">$4.0 million upon first commercial sale in a major EU country (United Kingdom, France, Germany, Italy and Spain);<br /> <br /></font></dd> <dt style="MARGIN-BOTTOM: -11pt; FONT-FAMILY: times"><font size="2">(c)</font></dt> <dd style="FONT-FAMILY: times"><font size="2">$8.0 million when annual net sales collected reach $100.0 million;<br /> <br /></font></dd> <dt style="MARGIN-BOTTOM: -11pt; FONT-FAMILY: times"><font size="2">(d)</font></dt> <dd style="FONT-FAMILY: times"><font size="2">$8.0 million when annual net sales collected reach $250.0 million; and<br /> <br /></font></dd> <dt style="MARGIN-BOTTOM: -11pt; FONT-FAMILY: times"><font size="2">(e)</font></dt> <dd style="FONT-FAMILY: times"><font size="2">$32.0 million when annual net sales collected reach $500.0 million.</font></dd></dl></li></ul> <p style="FONT-FAMILY: times"><font size="2">        The first contingency was resolved in April 2012 resulting in a $10.0 million payment to Skyepharma. The Company recorded this payment net of the $2.0 million contingent consideration liability recognized at the time of the Acquisition resulting in $8.0 million recorded as goodwill. Additionally, as of December 31, 2012, the Company also recorded $0.3 million as goodwill for the percentage payments on net sales of EXPAREL collected. Any remaining earn-out payments will also be treated as additional cost of the Acquisition and, therefore, recorded as goodwill if and when each contingency is resolved.</font></p> <p style="FONT-FAMILY: times"><font size="2">        Intangible assets, net consist of core technology, developed technology and trademarks and trade names acquired in the Acquisition as follows (in thousands):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="100%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="18"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="18"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="center" width="53"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="5"><font size="1"><b>Year Ended</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times" rowspan="2"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="5" rowspan="2"><font size="1"><b>December 31,</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times" rowspan="2"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" rowspan="2"><font size="1"><b>Estimated<br /> Useful Life</b></font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Core Technology</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Gross amount</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,900</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,900</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">9 years</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Accumulated amortization</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(1,853</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(1,530</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom" align="center"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 30pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Net</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,047</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,370</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom" align="center"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Developed Technology</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Gross amount</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">11,700</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">11,700</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">7 years</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Accumulated amortization</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(9,610</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(7,939</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom" align="center"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 30pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Net</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,090</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,761</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom" align="center"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Trademarks and trade names</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Gross amount</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">400</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">400</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">7 years</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Accumulated amortization</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(329</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(272</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom" align="center"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 30pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Net</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">71</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">128</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom" align="center"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Intangible assets, net</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,208</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,259</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom" align="center"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div> <p style="FONT-FAMILY: times"><font size="2">        Annual amortization expense for intangibles for the years ended December 31, 2012, 2011 and 2010 was $2.1 million, $2.3 million and $2.3 million, respectively.</font></p> <p style="FONT-FAMILY: times"><font size="2">        In December 2011, the Company was notified of the intent of its commercial partner, EKR Therapeutics, Inc., or EKR, to exit the DepoDur market. As a result, the Company recorded an impairment loss of $1.4 million representing the entire net intangible value of the DepoDur rights. In making the determination to impair the intangible asset, the Company also considered its inability to re-sublicense the product due to minimal supply revenue for the product both in the U.S. and in Europe as well as DepoDur's complex manufacturing process. Such impairment losses are reflected in impairment of long-lived assets in the Company's consolidated statements of operations.</font></p> <p style="FONT-FAMILY: times"><font size="2">        The approximate amortization expense for intangibles subject to amortization is as follows (in thousands):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="100%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="53"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="53"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="58"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="39"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Core<br /> Technology</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Developed<br /> Technology</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Trademarks<br /> and<br /> Tradenames</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Total</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2013</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">322</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,671</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">57</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,050</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2014</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">322</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">419</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">14</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">755</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2015</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">322</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">322</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2016</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">81</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">81</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,047</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,090</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">71</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,208</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
</us-gaap:IntangibleAssetsDisclosureTextBlock>
<us-gaap:AccountsPayableAndAccruedLiabilitiesDisclosureTextBlock id="Tag240" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b>NOTE 8—ACCRUED EXPENSES</b></font></p> <p style="FONT-FAMILY: times"><font size="2">        Accrued expenses consist of the following (in thousands):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="100%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="18"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="39"></td> <td style="FONT-FAMILY: times" width="18"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="39"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="5"><font size="1"><b>December 31,</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Compensation and benefits</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,635</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,824</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Accrued operating expenses</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,924</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,090</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Accrued royalties</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">360</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">345</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Accrued interest and end of term fee</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,873</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">900</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">9,792</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">7,159</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
</us-gaap:AccountsPayableAndAccruedLiabilitiesDisclosureTextBlock>
<us-gaap:DebtDisclosureTextBlock id="Tag241" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b>NOTE 9—DEBT</b></font></p> <p style="FONT-FAMILY: times"><font size="2">        The composition of the Company's debt and financing obligations is as follows (in thousands):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="100%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="5"><font size="1"><b>December 31,</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Debt:</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Current portion of long-term debt</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">7,039</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Long-term debt</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">27,500</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">19,211</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Discount on debt</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(2,309</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(674</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 30pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total debt, net of discount</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">25,191</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">25,576</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Royalty interest obligation:</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Current portion of royalty interest obligation</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">823</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,219</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Long-term portion of royalty interest obligation</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">857</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,537</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 30pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total royalty interest obligation</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,680</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,756</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 30pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total debt and financing obligations</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">26,871</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">28,332</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div> <p style="FONT-FAMILY: times"><font size="2"><i>Oxford Loan Facility</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        On May 2, 2012, the Company entered into a definitive loan and security agreement, or the Loan Agreement, with Oxford Finance LLC, or the Lender, and borrowed the principal amount of $27.5 million, or the Loan Facility, at a fixed rate of 9.75%, with the first principal payment due December 1, 2013. Payments under the Loan Agreement were interest-only in arrears through November 30, 2013, followed by 30 equal monthly payments of principal and interest. In addition, a payment equal to 6% of the Loan Facility was due on the final payment date, or such earlier date as specified in the Loan Agreement. The $1.65 million end of term fee was recorded as a debt discount and amortized to interest expense over the term of the loan. The proceeds from the Loan Agreement were used by the Company to repay the entire $24.2 million outstanding balance plus accrued interest, $0.6 million end of term fee and $0.3 million early prepayment penalty on its credit facility with Hercules Technology Growth Capital, Inc. and Hercules Technology II, L.P., as lenders, or Hercules Credit Facility. The Company recorded a loss on extinguishment of debt of $1.1 million comprised of the remaining unamortized debt issuance costs, warrants and end of term fee, as well as the early prepayment penalty on the note issued under the Hercules Credit Facility.</font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company's obligations under the Loan Agreement were secured by a first priority security interest in substantially all of its assets, other than its intellectual property. The Company agreed not to pledge or otherwise encumber its intellectual property assets, except for permitted liens or to the extent the intellectual property constitutes royalty collateral, as such terms are defined in the Loan Agreement and except as otherwise provided in the Loan Agreement.</font></p> <p style="FONT-FAMILY: times"><font size="2">        If the Company repaid all or a portion of the Loan Facility prior to maturity, it would pay the Lender a prepayment fee based on a percentage of the then outstanding principal balance equal to: 3.00% if the prepayment occurred prior to or on the first anniversary of the funding date, 2.00% if the prepayment occurs after the first anniversary of the funding date but prior to or on the second anniversary of the funding date, or 1.00% if the prepayment occurs after the second anniversary of the funding date.</font></p> <p style="FONT-FAMILY: times"><font size="2">        The Loan Agreement includes customary affirmative and restrictive covenants for transactions of this type and customary events of default, including the following events of default: payment defaults, breaches of covenants, judgment defaults, cross defaults to certain other contracts, the occurrence of certain events under the Company's royalty agreements, certain events with respect to governmental approvals if such events could cause a material adverse change, a material impairment in the perfection or priority of the Lender's security interest or in the value of the collateral, a material adverse change in the business, operations or condition of the Company or any of its subsidiaries and a material impairment of the prospect of repayment of the loans. Upon the occurrence of an event of default, a default increase in the interest rate of an additional 5.00% could be applied to the outstanding loan balance and the Lender could declare all outstanding obligations immediately due and payable and take such other actions as set forth in the Loan Agreement.</font></p> <p style="FONT-FAMILY: times"><font size="2">        In connection with the Loan Agreement, the Company issued to the Lender warrants that are exercisable for an aggregate of 162,885 shares of its common stock at a per share exercise price of $10.97. Each warrant may be exercised on a cashless basis in whole or in part. The value of the warrants was recorded as a debt discount and amortized over the term of the loan to interest expense. The fair value of the warrants was determined using Black-Scholes option model (using a discount rate of 1.96%, volatility of 69.69%, a dividend yield of 0%, and a contractual term of 10 years). The relative fair value of the warrants totaled $1.4 million.</font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company's principal payments were due under the Loan Agreement as follows: $0.8 million in 2013, $10.3 million in 2014, $11.3 million in 2015 and $5.1 million in 2016. See Note 19,</font> <font size="2"><i>Subsequent Events</i></font><font size="2">, for further discussion.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Hercules Credit Facility</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        On November 24, 2010, the Company entered into the $26.3 million Hercules Credit Facility. At the closing of the Hercules Credit Facility, the Company entered into a term loan in the aggregate principal amount of $26.3 million, which was the full amount available under the facility. The term loan under the Hercules Credit Facility was comprised of two tranches, Tranche A and Tranche B. The Tranche A portion of the term loan was comprised of $11.3 million in principal and carried a floating per annum interest rate equal to 10.25% plus the amount, if any, by which the prime rate exceeds 4.00%. Upon the release of the investors' guaranty in November 2011, the interest rate on the Tranche A portion of the term loan was increased to a floating per annum interest rate equal to 11.00% plus the amount, if any, by which the prime rate exceeds 4.00%. The Tranche B portion of the term loan was comprised of $15.0 million in principal and carried a floating per annum interest rate equal to 12.65% plus the amount, if any, by which the prime rate exceeds 4.00%. As of December 31, 2011, the blended interest rate was 11.94%.</font></p> <p style="FONT-FAMILY: times"><font size="2">        As further consideration to the lenders to provide the term loan to the Company under the Hercules Credit Facility, the Company issued a warrant to purchase 178,986 shares of the Company's stock.</font></p> <p style="FONT-FAMILY: times"><font size="2">        The term loan under the Hercules Credit Facility was terminated in May 2012.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Sale of Royalty Interests</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        In 2000, PPI-California and SkyePharma PLC entered into a Royalty Interests Assignment Agreement ("PLC Royalty Agreement") with an affiliate of Paul Capital Advisors, LLC ("Paul Capital") to raise $30.0 million. Under the PLC Royalty Agreement, Paul Capital had the right to receive a royalty interest in four of SkyePharma's product sales including product sales of, and other payments related to DepoCyt(e) and DepoDur. Payments began for product sales realized on or after January 1, 2003 and continue through December 31, 2014.</font></p> <p style="FONT-FAMILY: times"><font size="2">        In connection with the Acquisition, the PLC Royalty Agreement was amended ("Amended and Restated Royalty Interests Assignment Agreement"). As part of this amendment the responsibility to pay the royalty interest in product sales of DepoCyt(e) and DepoDur were transferred to the Company and the payment to Paul Capital in a "Purchase Option Event" of the Company, as described below, was defined. The net present value of royalties expected to be repaid to Paul Capital (the "royalty interest obligation") was valued at $13.0 million.</font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company recorded the royalty interest obligation as a liability in the Company's consolidated balance sheets in accordance with ASC 470-10-25, Sales of Future Revenues. The Company imputes interest expense associated with this liability using the effective interest rate method. The effective interest rate may vary during the term of the agreement depending on a number of factors including the actual sales of DepoCyt(e) and DepoDur and a significant estimation, performed quarterly, of certain of the Company's future cash flows related to these products during the remaining term of the Royalty Interests Assignment Agreement which terminates on December 31, 2014. Any adjustment to the estimates is reflected in the Company's consolidated statements of operations as interest income (expense). In addition, such cash flows are subject to foreign exchange movements related to sales of DepoCyt(e) and DepoDur denominated in currencies other than U.S. dollars.</font></p> <p style="FONT-FAMILY: times"><font size="2">        The PLC Royalty Agreement also includes a provision for a "Purchase Option Event." The events include: (1) any change of control, a direct or indirect consequence of which is a material abatement of efforts to develop, market or sell any of the products or reformulated products; or (2) the transfer by the parent of all or substantially all of the parent's consolidated assets; or (3) the transfer by the Company of all or any part of their respective interests in the products or reformulated products, or (4) bankruptcy or other breach or default under the agreement. In the event a Purchase Option Event occurs, Paul Capital shall have the right, but not the obligation, exercisable within 90 days, to require the Company to repurchase from Paul Capital the Royalty Interests Assignment, for a repurchase price equal to 50% of the cumulative amount of all payments made during the preceding 24 months (calculated from the date of the Purchaser's receipt of the notice from the Company of the Purchase Option Event) multiplied by the number of days from the date of Paul Capital's exercise of such option until December 31, 2014, divided by 365.</font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company has no minimum payment obligations under the PLC Royalty Agreement. However, the repayment of the Paul Capital liability is supported through a jointly controlled lockbox, where all DepoCyt(e) and DepoDur supply revenue and royalties are received as discussed in Note 2,</font> <font size="2"><i>Summary of Significant Accounting Policies</i></font><font size="2">.</font></p></div>
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<us-gaap:StockholdersEquityNoteDisclosureTextBlock id="Tag242" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b>NOTE 10—STOCKHOLDERS' EQUITY</b></font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Common Stock</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        On February 8, 2011, the Company completed an initial public offering of common stock for an aggregate of 6,000,000 shares and raised $37.1 million in net proceeds after deducting underwriting discounts and offering expenses. In November 2011, the Company raised an additional $49.0 million in net proceeds after deducting underwriting discounts and offering expenses in a registered public offering of common stock for an aggregate of 8,050,000 shares.</font></p> <p style="FONT-FAMILY: times"><font size="2">        In April 2012, the Company sold 6,900,000 shares of common stock at a price of $9.75 per share in a registered public offering, which includes the underwriter's exercise of the overallotment option. The Company raised approximately $62.9 million in net proceeds after deducting discounts and offering expenses.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Convertible Preferred Stock</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        Upon the closing of the initial public offering in February 2011, all outstanding shares of Series A convertible preferred stock and the principal and accrued interest balance totaling $51.2 million on the convertible promissory notes sold in January 2009, the secured notes sold in June 2009, the secured notes sold in March 2010, the convertible promissory notes sold in December 2010, and the secured notes sold in April 2010 were converted into an aggregate of 10,647,549 shares of common stock, as shown in the table below.</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="100%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="87"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Conversion Shares</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Series A Convertible Preferred Stock</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">6,322,640</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2009 Convertible Notes</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">871,635</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2009 Secured Notes</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">927,881</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2010 Secured Notes</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,156,606</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">HBM Secured Notes</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">297,359</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2010 Convertible Notes</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,071,428</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div> <p style="FONT-FAMILY: times"><font size="2"><i>Warrants</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        On May 2, 2012, the Company issued warrants to the Lender in connection with the Loan Agreement that are exercisable for an aggregate of 162,885 shares of its common stock at a per share exercise price of $10.97. On October 5, 2012, the Lender exercised the warrants on a cashless basis and received 67,279 shares of common stock. At December 31, 2012 and 2011, the Company had 490,464 and 527,656 warrants outstanding at a weighted average exercise price of $10.79 and $10.22, respectively.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Accumulated Other Comprehensive Income</i></font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="100%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="101"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="101"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Net Unrealized Gains<br /> (Losses) From<br /> Marketable Securities</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Total Accumulated<br /> Other Comprehesive<br /> Income (Loss)</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Balances at December 31, 2010</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$—  </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$—  </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Period Change</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">15  </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">15  </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Balances at December 31, 2011</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$15  </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$15  </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Period Change</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">12  </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">12  </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Balances at December 31, 2012</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$27  </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$27  </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
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<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b>NOTE 11—STOCK PLANS</b></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company's 2007 stock incentive plan, or 2007 Plan, provides 1,729,498 shares for issuance. The Company's 2011 stock incentive plan, or 2011 Plan, which became effective immediately prior to the completion of the Company's initial public offering in February 2011, was adopted by its board of directors and approved by its stockholders in December 2010. The 2011 Plan provides for the grant of incentive stock options, non-statutory stock options, restricted stock awards and other stock-based awards. The remaining shares available for issuance under the 2007 Plan at the time of the completion of the Company's initial public offering were reallocated to the 2011 Plan. The 2011 Plan also increased the shares reserved for issuance from 1,729,498 to 2,546,657 shares. The 2011 Plan contained an "evergreen" provision, which allowed for an annual increase of up to 557,880 shares available for issuance under the 2011 Plan on the first day of each calendar year from 2012 through 2015. On January 1, 2012, the evergreen provision increased the number of shares of common stock authorized for issuance under the 2011 stock plan by 557,880 shares. On June 5, 2012, the 2011 Plan was amended, to, among other things: (i) increase the number of shares of common stock authorized for issuance under the 2011 Plan by 2,100,000, (ii) remove the evergreen provision and (iii) require stockholder approval prior to any repricing of awards granted under the 2011 Plan.</font></p> <p style="FONT-FAMILY: times"><font size="2">        The following table contains information about the Company's plans at December 31, 2012:</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="100%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="79"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="68"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="79"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" nowrap="nowrap" align="left"> <div style="MARGIN-BOTTOM: 0pt; WIDTH: 16pt; BORDER-BOTTOM: #000000 1pt solid"><font size="1"><b>Plan <!-- COMMAND=ADD_SCROPPEDRULE,16pt --></b></font></div></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Awards Reserved<br /> for Issuance</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Awards Issued</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Awards Available<br /> for Grant</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2011 Plan</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,138,519</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,393,214</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">745,305</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2007 Plan</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,066,018</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,066,018</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"> </p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,204,537</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">4,459,232</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">745,305</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div> <p style="FONT-FAMILY: times"><font size="2"><i>Stock-Based Compensation</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company recognized stock-based compensation in its consolidated statements of operations for the years ended December 31, 2012, 2011 and 2010 as follows (in thousands):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="100%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="39"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="39"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="25"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="8"><font size="1"><b>Year Ended December 31,</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2010</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Cost of revenues</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">563</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">218</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">12</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Research and development</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,155</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">804</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">10</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Selling, general and administrative</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,058</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,471</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">4,776</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,493</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">23</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div> <p style="FONT-FAMILY: times"><font size="2">        The following table summarizes the Company's stock option activity and related information for the period from January 1, 2010 to December 31, 2012 (in thousands except share and per share amounts):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 10%; WIDTH: 73%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"110%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="110%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="55"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="75"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="78"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="69"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Number of<br /> shares</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Weighted<br /> average exercise<br /> price</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Weighted<br /> Average<br /> remaining<br /> contractual term<br /> (years)</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Aggregate<br /> intrinsic value<br /> (in thousands)</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Outstanding at January 1, 2010</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">52,430</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">1.79</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">8.06</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">47</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="white"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Granted</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">2,028,158</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">2.71</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Exercised</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(1,177</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">1.89</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">1</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="white"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Forfeited</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(3,337</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">1.89</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Expired</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(2,374</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">1.75</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom" align="right"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="white"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Outstanding at December 31, 2010</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">2,073,700</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">2.69</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">9.70</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">6</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Granted</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">395,234</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">10.21</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="white"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Exercised</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(67,456</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">2.01</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">420</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Forfeited</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(62,776</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">5.05</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="white"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Expired</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(1,685</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">2.69</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom" align="right"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Outstanding at December 31, 2011</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">2,337,017</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">3.92</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">8.80</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">11,829</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="white"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Granted</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">2,120,250</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">11.55</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Exercised</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(279,476</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">2.75</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">3,005</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="white"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Forfeited</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(174,610</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">7.94</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Expired</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(15</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">7.07</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom" align="right"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="white"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Outstanding at December 31, 2012</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">4,003,166</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">7.86</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">8.66</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">38,485</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Exercisable at December 31, 2012</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">1,269,921</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">3.76</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">7.80</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">17,415</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="white"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Vested and expected to vest at December 31, 2012</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">3,889,392</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">7.78</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">8.64</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">37,686</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div> <p style="FONT-FAMILY: times"><font size="2">        As of December 31, 2012, $17.7 million of total unrecognized compensation cost related to non-vested stock options is expected to be recognized over the respective vesting terms of each award. The weighted average contractual term of the unrecognized stock-based compensation is approximately 3 years.</font></p> <p style="FONT-FAMILY: times"><font size="2">        The weighted average fair value of stock options granted for the years ended December 31, 2012, 2011 and 2010 was $8.52, $7.06 and $5.61 per share, respectively. The fair values of stock options granted were estimated using the Black-Scholes option pricing model with the following weighted average assumptions:</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="100%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="center" width="73"></td> <td style="FONT-FAMILY: times" width="14"></td> <td style="FONT-FAMILY: times" align="center" width="60"></td> <td style="FONT-FAMILY: times" width="14"></td> <td style="FONT-FAMILY: times" align="center" width="60"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="5"><font size="1"><b>Year Ended December 31,</b></font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center"><font size="1"><b>2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center"><font size="1"><b>2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center"><font size="1"><b>2010</b></font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Expected dividend yield</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">None</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">None</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">None</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Risk free interest rate</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">0.84 - 1.70%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">1.1 - 2.7%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">1.6 - 3.4%</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Expected volatility</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">74.0%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">76.8%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">80.8%</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Expected life of options</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">6.76 years</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">6.73 years</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">6.25 years</font></td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
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<pcrx:CostOfRevenuesDisclosureTextBlock id="Tag244" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b>NOTE 13—COST OF REVENUES</b></font></p> <p style="FONT-FAMILY: times"><font size="2">        Cost of revenues consists of the following (in thousands):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="100%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="8"><font size="1"><b>Year Ended December 31,</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2010</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Cost of goods sold</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">31,744</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">15,310</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">11,374</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Cost of collaborative licensing and development</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">395</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,429</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">902</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total cost of revenues</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">32,139</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">16,739</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">12,276</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div> <p style="FONT-FAMILY: times"><font size="2">        Cost of goods sold consists of the manufacturing and allocated overhead costs related to the Company's products. Cost of collaborative licensing and development consists of the Company's expenses related to feasibility studies and development work for third parties who desire to utilize the Company's DepoFoam extended release drug delivery technology for their products. Cost of goods sold and cost of collaborative licensing and development both include royalties due to Research Development Foundation ("RDF") for the use of DepoFoam technology.</font></p></div>
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<us-gaap:IncomeTaxDisclosureTextBlock id="Tag245" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b>NOTE 14—INCOME TAXES</b></font></p> <p style="FONT-FAMILY: times"><font size="2">        A reconciliation of income taxes at the U.S. Federal statutory rate to the provision for income taxes is as follows:</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="100%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="37"></td> <td style="FONT-FAMILY: times" width="16"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="37"></td> <td style="FONT-FAMILY: times" width="16"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="37"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="8"><font size="1"><b>Year Ended December 31,</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2010</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Benefit at U.S. Federal statutory rate</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">35.00</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">35.00</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">35.00</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">State taxes—deferred</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">6.73</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3.98</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">7.75</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Increase in valuation allowance</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(39.62</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(38.27</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(44.77</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)%</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Tax credits</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">0.00</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">0.13</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">0.18</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Other</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(2.11</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(0.84</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1.84</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Provision for income taxes</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">0.00</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">0.00</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">0.00</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div> <p style="FONT-FAMILY: times"><font size="2">        Significant components of the Company's deferred tax assets are as follows (in thousands):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="100%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="56"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="50"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="5"><font size="1"><b>December 31,</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Deferred tax assets:</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Federal and state net operating loss carry-forwards</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">89,150</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">62,231</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Federal and state research credits</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,631</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,395</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Depreciation and amortization</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,891</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">4,867</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Accruals and reserves</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,388</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,685</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Deferred revenue</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,897</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">8,745</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Other</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,997</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,325</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total gross deferred tax assets</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">103,954</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">83,248</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Less valuation allowance for deferred tax assets</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(103,954</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(83,248</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Net deferred tax assets</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div> <p style="FONT-FAMILY: times"><font size="2">        The Company has significant federal and state net operating loss carryforwards and federal and state research and development tax credit carryforwards. As of December 31, 2012, federal and state net operating losses totaled $219.2 million and $216.1 million, respectively. The Company also had federal and state research and development tax credit carry-forwards of approximately $2.6 million and $1.6 million, respectively. The net operating loss carryforwards will begin expiring in 2026 for federal purposes and 2015 for state purposes if the Company has not used them prior to that time, and the federal tax credits will begin expiring in 2028 unless previously used. The state tax credits carry forward indefinitely. There is significant doubt regarding the Company's ability to utilize its net deferred tax assets and, therefore, the Company has recorded a full valuation allowance. The valuation allowance for deferred tax assets increased by approximately $20.7 million, $16.6 million and $12.2 million during the years ended December 31, 2012, 2011 and 2010, respectively.</font></p> <p style="FONT-FAMILY: times"><font size="2">        Additionally, the Company's ability to use any net operating loss and credit carryforwards to offset taxable income or tax, respectively, in the future will be limited under Internal Revenue Code Sections 382 and 383 since the Company had a cumulative change in ownership of more than 50% within the three-year period. Such an ownership change was triggered by the cumulative ownership changes arising as a result of the completion of the initial public offering and other financing transactions. Because of the ownership change, the Company will be limited regarding the amount of net operating loss carryforwards and research tax credits that it can utilize annually in the future to offset taxable income or tax, respectively. The annual limitation may significantly reduce the utilization of the net operating loss carryforwards and research tax credits before they expire. In addition, California and certain states have suspended use of net operating loss carryforwards for certain taxable years, and other states are considering similar measures. As a result, the Company may incur higher state income tax expense in the future.</font></p> <p style="FONT-FAMILY: times"><font size="2">        The Acquisition was treated as a stock acquisition for tax purposes and, therefore, the acquired intangibles for book purposes are not deductible for income tax purposes. The Company also recorded goodwill relating to contingent payments due under the Acquisition during the year ended December 31, 2012, which is not deductible for income tax purposes.</font></p> <p style="FONT-FAMILY: times"><font size="2">        In connection with the adoption of stock-based compensation guidance in 2006, the Company elected to follow the with-and-without approach to determine the sequence in which deductions and net operating loss carryforwards are utilized. Accordingly, no tax benefit related to stock options was recognized in the current year. At December 31, 2012, the Company has approximately $2.2 million of net operating loss carryforwards that relate to stock-based compensation for which future tax benefits will be credited to equity.</font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company evaluates its uncertain tax positions in a two-step process. The Company first determines whether it is more-likely-than-not that a tax position will be sustained upon examination. If a tax position meets the more-likely-than-not recognition threshold it is then measured to determine the amount of benefit to be recognized in the financial statements. The tax position is measured as the largest amount of benefit that has a greater than 50% likelihood of being realized upon ultimate settlement.</font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company did not have a liability related to unrecognized tax benefits as of December 31, 2012 and 2011 due to operating losses but has reduced its deferred tax assets by $0.4 million at December 31, 2012 and 2011. Further, because the Company has recorded a full valuation allowance on its net deferred assets, the effect of implementing ASC 740 has been a reduction of the allowance by the amount above. A reconciliation of the beginning and ending amount of gross unrecognized tax benefit is as follows:</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="100%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="30"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="30"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="5"><font size="1"><b>Year Ended<br /> December 31,</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Balance at beginning of year</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">420</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">420</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Increases related to tax positions taken during the current year</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Increases related to tax positions taken during a prior period</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Balance at end of year</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">420</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">420</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div> <p style="FONT-FAMILY: times"><font size="2">        No interest or penalties were accrued for 2012, 2011 or 2010. The Company is currently open for audit by the United States Internal Revenue Service and state tax jurisdictions for 2006 through 2012. The American Tax Relief Act of 2012, enacted on January 2, 2013, retroactively reinstated the research and development tax credit for 2012. The Company will report credits of approximately $0.2 million for federal income tax purposes in the first quarter of 2013.</font></p></div>
</us-gaap:IncomeTaxDisclosureTextBlock>
<us-gaap:CompensationAndEmployeeBenefitPlansTextBlock id="Tag246" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b>NOTE 15—OTHER EMPLOYEE BENEFITS</b></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company sponsors a 401(k) savings plan. Under the plan, employees may make contributions to the plan, which are eligible for a discretionary percentage match as defined in the plan and determined by the board of directors. The Company recognized $0.3 million, $0.2 million and $0.0 million of related compensation expense for the years ended December 31, 2012, 2011 and 2010, respectively.</font></p></div>
</us-gaap:CompensationAndEmployeeBenefitPlansTextBlock>
<pcrx:CommercialPartnersAndAgreementsTextBlock id="Tag247" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b>NOTE 16—COMMERCIAL PARTNERS AND OTHER AGREEMENTS</b></font></p> <p style="FONT-FAMILY: times"><font size="2"><b><i>Commercial Partners</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Aratana Therapeutics, Inc.</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        On December 5, 2012, the Company entered into a worldwide license, development and commercialization agreement with Aratana Therapeutics, Inc., or Aratana. Under the agreement, the Company granted Aratana an exclusive royalty-bearing license, including the limited right to grant sublicenses, for the development and commercialization of the Company's bupivacaine liposome injectable suspension product for animal health indications. Under the agreement, Aratana will develop and seek approval for the use of the product in veterinary surgery to manage postsurgical pain, focusing initially on developing the product for cats, dogs and other companion animals. In connection with its entry into the license agreement, the Company received a one-time payment of $1.0 million and is eligible to receive up to an additional aggregate $42.5 million upon the achievement of development and commercial milestones. Once the product has been approved by the Food and Drug Administration for sale in the United States, Aratana will pay the Company a tiered double digit royalty on net sales made in the United States. If the product is approved by foreign regulatory agencies for sale outside of the United States, Aratana will pay the Company a tiered double digit royalty on such net sales. Royalty rates will be reduced by a certain percentage upon the entry of a generic competitor for animal health indications into a jurisdiction or if Aratana must pay royalties to third parties under certain circumstances.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Mundipharma International Holdings Limited</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        In June 2003, the Company entered into an agreement granting Mundipharma International Holdings Limited, or Mundipharma, exclusive marketing and distribution rights to DepoCyte in the European Union and certain other European countries. Under the agreement, as amended, and a separate supply agreement, the Company receives a fixed payment for manufacturing the vials of DepoCyte and a double-digit royalty, net of supply price, on sales in the applicable territories.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Sigma -Tau</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        In December 2002, the Company entered into a supply and distribution agreement with Enzon Pharmaceuticals Inc., subsequently acquired by Sigma-Tau Pharmaceuticals, Inc., or Sigma-Tau, regarding the sale of DepoCyt. Pursuant to the agreement, Sigma-Tau was appointed the exclusive distributor of DepoCyt in the United States and Canada. Under the supply and distribution agreement, the Company supplies unlabeled DepoCyt vials to Sigma-Tau for finished packaging by Sigma-Tau. Under these agreements, the Company receives a fixed payment for manufacturing the vials of DepoCyt and a double-digit royalty on sales, net of supply price, in the United States and Canada.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>EKR Therapeutics, Inc.</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        On January 3, 2012, EKR Therapeutics, Inc., or EKR, delivered a notice to the Company to terminate the licensing, distribution and marketing agreement relating to DepoDur. Pursuant to the terms of the agreement, the termination of the agreement was effective on July 1, 2012. The associated supply agreement also terminated concurrently with the termination of the licensing, distribution and marketing agreement. Both parties agreed to terminate the agreements effective June 8, 2012. As a result of the termination, the Company recognized any unamortized deferred revenue relating to the agreement on a straight-line basis through the termination date in June 2012.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Flynn Pharmaceuticals Limited</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        On October 29, 2012, the Company terminated the marketing agreement with Flynn Pharma Limited, or Flynn, which had granted exclusive distribution rights to DepoDur in the European Union, certain other European countries, South Africa and the Middle East. The supply agreement terminated concurrently with the marketing agreement. The termination was effective immediately. As a result of the termination, the Company recognized any unamortized deferred revenue relating to the agreement upon termination.</font></p> <p style="FONT-FAMILY: times"><font size="2"><b><i>Other Agreements</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        In the ordinary course of its business activities, the Company enters into agreements with third parties who desire access to its proprietary DepoFoam extended release drug delivery technology to conduct research, feasibility and formulation work. Under these agreements, the Company is compensated to perform feasibility testing on a third party product to determine the likelihood of developing a successful formulation of that product using its proprietary DepoFoam extended release drug delivery technology. If successful in the feasibility stage, these programs can advance to a full development contract.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Novo Nordisk</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        On June 29, 2012, the Company received a notice of termination from Novo Nordisk AS, or Novo, of the Development and License Agreement, dated January 14, 2011, which had granted non-exclusive rights to Novo under certain of its patents and know-how to develop, manufacture and commercialize formulations of a Novo proprietary drug using the Company's DepoFoam drug delivery technology. The Company received a one-time upfront payment of $1.5 million in January 2011 and a milestone payment of $2.0 million in November 2011, both of which had been deferred and was being recognized on a straight-line basis over the estimated contract period to collobrative licensing and development revenue in the consolidated statements of operations. Pursuant to the terms of the agreement, the termination of the agreement was effective on August 28, 2012. The agreement was terminated due to Novo's decision to discontinue development of the proprietary drug subject to the agreement. As a result of the termination, the Company recognized any unamortized deferred revenue relating to the agreement on a straight-line basis through the termination date in August 2012.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Amylin Pharmaceuticals, Inc.</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        In March 2008, the Company entered into a development and licensing agreement with Amylin Pharmaceuticals, Inc., or Amylin. Under the development and licensing agreement, the Company provides Amylin with access to its proprietary DepoFoam drug delivery technology to conduct research, feasibility and formulation work, and for the manufacturing of pre-clinical and clinical material for various Amylin products. The Company is entitled to payments from Amylin for its work on the formulation and development of compounds with the DepoFoam technology, its achievement of certain clinical development milestones, its achievement of certain worldwide sales and a tiered royalty based upon sales. The development and licensing agreement with Amylin remains effective, however, neither party is currently performing any activities under the agreement.</font></p></div>
</pcrx:CommercialPartnersAndAgreementsTextBlock>
<us-gaap:RelatedPartyTransactionsDisclosureTextBlock id="Tag248" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b>NOTE 17—RELATED PARTY TRANSACTIONS</b></font></p> <p style="FONT-FAMILY: times"><font size="2">        MPM Asset Management, or MPM, an investor in the Company, holds a seat on the Company's board of directors. MPM provides clinical management consulting services to the Company through Gary Patou, or Consultant, the Company's Chief Medical Officer. In October 2010, the Company entered into an agreement with MPM to provide services at a monthly rate of approximately $26,000 in 2010 and 2011 in exchange for 80% of Consultant's business time devoted to the Company, $16,000 in 2012 in exchange for 50% of Consultant's business time and $6,000 in 2013 and 2014 in exchange for 20% of Consultant's business time. The original services agreement has been amended twice. The first amendment to this agreement was entered into in December 2011 and declared that Consultant will continue to earn a monthly consulting fee of approximately $26,000 in exchange for 80% of its business time through September 30, 2012. In November 2012, the Company entered into a second amendment to the services agreement with MPM. Pursuant to the terms of the amended services agreement, the monthly services fee will remain at approximately $16,000, through December 31, 2013, in exchange for 50% of Consultant's business time. The Company incurred expenses of $0.4 million, $0.5 million and $0.7 million for the years ended December 31, 2012, 2011 and 2010, respectively. As of December 31, 2012 and 2011, $0.1 million and $0.2 million, respectively, was payable to MPM.</font></p> <p style="FONT-FAMILY: times"><font size="2">        In December 2012, the Company entered into a worldwide license, development and commercialization agreement with Aratana as discussed in Note 16,</font> <font size="2"><i>Commercial Partners and Other Agreements</i></font><font size="2">. MPM and its affiliates are holders of capital stock of Aratana.</font></p> <p style="FONT-FAMILY: times"><font size="2">        In April 2010, the Company signed a statement of work for a feasibility study with Rhythm Pharmaceuticals, Inc., or Rhythm. During the year ended December 31, 2010, the Company earned $0.3 million contract revenue from this statement of work. MPM and its affiliates are holders of capital stock of Rhythm and a managing director of MPM is a member of the board of directors of Rhythm.</font></p> <p style="FONT-FAMILY: times"><font size="2">        In June 2011, the Company entered into an agreement with Gary Pace, a member of its board of directors, to provide consulting services for manufacturing-related activities at a monthly fee of $5,000, not to exceed $60,000 annually. In connection with these services, Dr. Pace received an option to purchase 10,000 shares of common stock at an exercise price of $11.02 per share. In April 2012, the Company entered into an amended and restated consulting agreement with Gary Pace, whereby Dr. Pace will provide consulting services at the rate of $10,000 per month and received an option to purchase 20,000 shares of common stock at an exercise price of $11.02 per share pursuant to the amended and restated consulting agreement. The amendment also removed the stipulation that Dr. Pace's total yearly consulting fees could not exceed $60,000. In August 2012, the Company further amended and restated the consulting agreement with Gary Pace, whereby Dr. Pace will provide consulting services at the rate of $15,000 per month and received an option to purchase 70,000 shares of common stock at an exercise price of $16.67 per share pursuant to the amended and restated consulting agreement. Under this amendment, Dr. Pace will be eligible to receive a bonus up to $0.2 million, contingent upon the date of FDA approval of the Company's Suite C manufacturing facility for EXPAREL. The Company recorded expenses under the consulting arrangement for the years ended December 31, 2012 and 2011 of $0.2 million and less than $0.1 million, respectively.</font></p> <p style="FONT-FAMILY: times"><font size="2">        In November 2011, the Company terminated its services agreement with Stack Pharmaceuticals Inc., or SPI, an entity controlled by David Stack, the Company's chief executive officer. SPI had provided the Company with the use of SPI's office facilities and certain consulting services. In November 2011, the Company also purchased $0.02 million of office furniture and equipment from SPI. The Company incurred expenses under the SPI agreement of $0.2 million and $0.3 million for the years ended December 31, 2011 and 2010, respectively. As of December 31, 2012 and 2011, the Company had no outstanding balance payable to SPI.</font></p></div>
</us-gaap:RelatedPartyTransactionsDisclosureTextBlock>
<us-gaap:CommitmentsAndContingenciesDisclosureTextBlock id="Tag249" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b>NOTE 18—COMMITMENTS AND CONTINGENCIES</b></font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Leases</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        In August 2011, the Company entered into a new lease contract for its corporate headquarters in Parsippany, New Jersey. The lease, which occupies approximately 13,000 square feet, expires in June 2017. Under the lease, the Company is required to pay certain maintenance expenses in addition to rent.</font></p> <p style="FONT-FAMILY: times"><font size="2">        In addition, the Company leases research and development and manufacturing facilities in San Diego, California, in two facilities occupying approximately 106,000 square feet, referred to as the Science Center campus. The leases expire in July 2015. Under these leases, the Company is required to pay certain maintenance expenses in addition to the monthly rent. In connection with the Acquisition, the Company determined that its lease rates associated with the Science Center campus were in excess of market rates resulting in a $3.3 million unfavorable lease accrual as of the Acquisition date. The unfavorable lease accrual, which is recorded in other long-term liabilities in the Company's consolidated balance sheets, is amortized over the remaining terms of the leases. The annual amortization of the unfavorable lease accrual for each of the years ended December 31, 2012, 2011 and 2010 was $0.4 million. In December 2012, the Company signed a letter of intent to negotiate an extension of the leases for the Science Center campus through August 31, 2020.</font></p> <p style="FONT-FAMILY: times"><font size="2">        As of December 31, 2012, annual minimum payments due under the Company's lease obligations are as follows (in thousands):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="100%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" nowrap="nowrap" align="left"> <div style="MARGIN-BOTTOM: 0pt; WIDTH: 16pt; BORDER-BOTTOM: #000000 1pt solid"><font size="1"><b>Year <!-- COMMAND=ADD_SCROPPEDRULE,16pt --></b></font></div></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="FONT-FAMILY: times" align="center" colspan="2"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2013</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,284</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2014</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,463</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2015</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,464</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2016</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">405</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2017</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">201</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">14,817</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div> <p style="FONT-FAMILY: times"><font size="2">        Total rent expense, net of unfavorable lease obligation amortization, under all operating leases for years ended December 31, 2012, 2011 and 2010 was $4.8 million, $4.7 million and $4.5 million, respectively. Deferred rent at December 31, 2012 and 2011 was $1.3 million and $1.4 million, respectively.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Litigation</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company periodically becomes subject to legal proceedings and claims arising in connection with its business. The ultimate legal and financial liability of the Company in respect to all claims, lawsuits and proceedings cannot be estimated with any certainty. Any outcome, either individually or in the aggregate, is not expected to be material to the Company's consolidated financial position, results of operations, or cash flows.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Other Contingencies and Commitments</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        In July 2012, the Company received an inspection letter from the MHRA noting certain critical and major failures to comply with the Principles and Guidelines of Good Manufacturing Practices in the DepoCyt(e) manufacturing line, which is located in a separate building from the EXPAREL manufacturing site. As a result of the findings, the European Medicines Agency issued an assessment report which recommended that, until corrective actions are taken allowing new supply to enter the market, alternative medicines be used in European Union member countries where there are suitable alternatives. The assessment report also recommended a selective recall of DepoCyt(e) in European Union member countries where DepoCyt(e) is not considered to be an "essential medicinal product." In European Union member countries where the product is classified as an "essential medicinal product," DepoCyte can be used with specific recommendations to monitor patients' safety. No regulatory action has been taken by the FDA in the United States as a result of these inspection findings.</font></p> <p style="FONT-FAMILY: times"><font size="2">        During the year ended December 31, 2012, the Company recorded a charge of $1.3 million, in cost of revenues associated with the implementation of a remediation plan and estimated costs to replace the product once new product is available in Europe, which is expected in mid-2013. While the corrective actions and upgrades to the facilities were taking place, the Company stopped manufacturing DepoCyt(e). In December 2012, the MHRA re-inspected the DepoCyt(e) manufacturing facility to review progress in the implementation of the remediation commitments arising from the July 2012 inspection. The Company received notice in January 2013 from the MHRA that the Company's remediation efforts were successful and it plans to resume production of DepoCyt(e) for the European market in the first quarter of 2013. The temporary cessation of the manufacturing of DepoCyt(e) could result in additional costs or delays in production and sale of DepoCyt(e).</font></p> <p style="FONT-FAMILY: times"><font size="2">        In May 2012, the Company entered into a construction management agreement with DPR Construction, a general partnership, or DPR. Under the terms of the agreement, DPR is responsible for the management of the renovation of the Company's existing manufacturing facility in San Diego, California. The manufacturing facility is being renovated to allow the Company to expand the current manufacturing capacity and meet anticipated future market demand for EXPAREL. Pursuant to the agreement, the contract sum (the cost of the work plus the contractor fee) will not exceed approximately $7.7 million, provided that such amount is subject to change based on agreed-upon changes to the scope of work.</font></p> <p style="FONT-FAMILY: times"><font size="2">        The FDA, as a condition of the EXPAREL approval, has required the Company to study EXPAREL in pediatric patients. The Company has agreed to a trial timeline where, over several years, it will study pediatric patient populations in descending order starting with 12 - 18 year olds and ending with children under two years of age. The cost to complete the trial may be significant.</font></p> <p style="FONT-FAMILY: times"><font size="2">        In addition to the initial $19.6 million purchase price for the Acquisition, the Company entered into an earn-out agreement with SkyePharma which was based on the Company reaching certain revenue milestones following the Acquisition. According to this agreement, the Company would pay SkyePharma percentage payments based on the net revenues of EXPAREL and certain other products from the future yet-to-be-developed biologics product line and milestone payments of up to an aggregate of $62.0 million upon the occurrence of the following events: (a) first commercial sale in the United States; (b) first commercial sale in a major EU country (UK, France, Germany, Italy, or Spain); (c) annual net sales reaching $100 million; (d) annual net sales reaching $250 million and (e) annual net sales reaching $500 million. Additionally, the Company agreed to pay to SkyePharma a 3% percentage payment on collections of EXPAREL sales in the United States, Japan, the United Kingdom, France, Germany, Italy and Spain. Refer to Note 7,</font> <font size="2"><i>Goodwill and Intangible Assets</i></font><font size="2">, for further discussion.</font></p></div>
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<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b>NOTE 19—SUBSEQUENT EVENTS</b></font></p> <p style="FONT-FAMILY: times"><font size="2">        On January 23, 2013, the Company completed a private offering of $120.0 million in aggregate principal amount of 3.25% convertible senior notes due 2019 ("Notes") and entered into an indenture with Wells Fargo Bank, National Association, a national banking association, as trustee, governing the Notes. The net proceeds from the offering are approximately $115.3 million, after deducting the initial purchasers' discounts and commissions and the estimated offering expenses payable by the Company. The Notes accrue interest at 3.25% per year, payable semiannually in arrears on February 1 and August 1 of each year, beginning on August 1, 2013. The Notes will mature on February 1, 2019.</font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company used $30.1 million of the net proceeds from the offering of the Notes to repay in full the $27.5 million credit facility with Oxford Finance LLC. In connection with such termination, the Company paid the remaining principal amount of $27.5 million as well as accrued interest, certain prepayment fees and an end of term charge in the aggregate amount of $2.6 million.</font></p></div>
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<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"> <p style="FONT-FAMILY: times"><font size="2">The carrying amount and fair value of the Company's long-term debt is for disclosure purposes only (in thousands):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 10%; WIDTH: 80%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table style="WIDTH: 710px; HEIGHT: 29px" cellspacing="0" cellpadding="0" width="710" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="18"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="36"></td> <td style="FONT-FAMILY: times" width="18"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="18"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="36"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="2"> </font></th> <th style="FONT-FAMILY: times" align="left" colspan="2"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times" rowspan="2"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="8" rowspan="2"><font size="1"><b>Fair Value Measurements Using</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times" rowspan="2"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2" rowspan="2"><font size="1"><b>Carrying<br /> Value</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" nowrap="nowrap" align="left"> <div style="MARGIN-BOTTOM: 0pt; WIDTH: 166pt; BORDER-BOTTOM: #000000 1pt solid"><font size="1"><b>Financial Liabilities Carried at Historical Cost <!-- COMMAND=ADD_SCROPPEDRULE,166pt --></b></font></div></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Level 1</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Level 2</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Level 3</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2"><b>December 31, 2012</b></font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Long term debt—current and long-term</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">27,500</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">28,497</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
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<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"> <p style="FONT-FAMILY: times"><font size="2">The following summarizes the Company's short-term investments at December 31, 2012 and 2011 (in thousands):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table style="WIDTH: 759px; HEIGHT: 48px" cellspacing="0" cellpadding="0" width="759" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="51"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="51"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="49"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" nowrap="nowrap" align="left"> <div style="MARGIN-BOTTOM: 0pt; WIDTH: 64pt; BORDER-BOTTOM: #000000 1pt solid"><font size="1"><b>December 31, 2012 <!-- COMMAND=ADD_SCROPPEDRULE,64pt --></b></font></div></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Cost</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Gross<br /> Unrealized<br /> Gains</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Gross<br /> Unrealized<br /> Losses</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Fair Value<br /> (Level 2)</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Debt securities:</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Commercial Paper</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">15,974</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">23</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">15,997</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Corporate Bonds</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">8,874</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(1</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">8,874</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Asset-backed Securities</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">6,049</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">4</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">6,053</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">30,897</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">28</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(1</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">30,924</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div> <p style="FONT-FAMILY: times"> </p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table style="WIDTH: 761px; HEIGHT: 139px" cellspacing="0" cellpadding="0" width="761" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="51"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="51"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="49"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" nowrap="nowrap" align="left"> <div style="MARGIN-BOTTOM: 0pt; WIDTH: 64pt; BORDER-BOTTOM: #000000 1pt solid"><font size="1"><b>December 31, 2011 <!-- COMMAND=ADD_SCROPPEDRULE,64pt --></b></font></div></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Cost</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Gross<br /> Unrealized<br /> Gains</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Gross<br /> Unrealized<br /> Losses</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Fair Value<br /> (Level 2)</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Debt securities:</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">US Treasury Securities</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,000</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,000</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Commercial Paper</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">11,476</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">23</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">11,499</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Corporate Bonds</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">17,494</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(10</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">17,486</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">29,970</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">25</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(10</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">29,985</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
</us-gaap:ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock>
<us-gaap:DebtInstrumentFairValue id="Tag253" decimals="-3" contextRef="I2012_CarryingReportedAmountFairValueDisclosureMember" unitRef="USD"> 27500000 </us-gaap:DebtInstrumentFairValue>
<us-gaap:DebtInstrumentFairValue id="Tag254" decimals="-3" contextRef="I2012_FairValueInputsLevel2Member" unitRef="USD"> 28497000 </us-gaap:DebtInstrumentFairValue>
<us-gaap:ShortTermInvestments id="Tag255" decimals="-3" contextRef="I2012" unitRef="USD"> 30924000 </us-gaap:ShortTermInvestments>
<pcrx:ShortTermInvestmentsMaturityPeriod id="Tag256" contextRef="D2012_MinimumMember"> P210D </pcrx:ShortTermInvestmentsMaturityPeriod>
<pcrx:ShortTermInvestmentsMaturityPeriod id="Tag257" contextRef="D2012_MaximumMember"> P356D </pcrx:ShortTermInvestmentsMaturityPeriod>
<us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis id="Tag258" decimals="-3" contextRef="I2012" unitRef="USD"> 30897000 </us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis>
<us-gaap:AvailableforsaleSecuritiesGrossUnrealizedGain id="Tag259" decimals="-3" contextRef="I2012" unitRef="USD"> 28000 </us-gaap:AvailableforsaleSecuritiesGrossUnrealizedGain>
<us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis id="Tag260" decimals="-3" contextRef="I2012_AssetBackedSecuritiesMember" unitRef="USD"> 6049000 </us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis>
<us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis id="Tag261" decimals="-3" contextRef="I2012_CommercialPaperMember" unitRef="USD"> 15974000 </us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis>
<us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis id="Tag262" decimals="-3" contextRef="I2012_CorporateBondSecuritiesMember" unitRef="USD"> 8874000 </us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis>
<us-gaap:AvailableforsaleSecuritiesGrossUnrealizedGain id="Tag263" decimals="-3" contextRef="I2012_AssetBackedSecuritiesMember" unitRef="USD"> 4000 </us-gaap:AvailableforsaleSecuritiesGrossUnrealizedGain>
<us-gaap:AvailableforsaleSecuritiesGrossUnrealizedGain id="Tag264" decimals="-3" contextRef="I2012_CommercialPaperMember" unitRef="USD"> 23000 </us-gaap:AvailableforsaleSecuritiesGrossUnrealizedGain>
<us-gaap:AvailableforsaleSecuritiesGrossUnrealizedGain id="Tag265" decimals="-3" contextRef="I2012_CorporateBondSecuritiesMember" unitRef="USD"> 1000 </us-gaap:AvailableforsaleSecuritiesGrossUnrealizedGain>
<us-gaap:AvailableForSaleSecuritiesGrossUnrealizedLosses1 id="Tag266" decimals="-3" contextRef="I2012" unitRef="USD"> 1000 </us-gaap:AvailableForSaleSecuritiesGrossUnrealizedLosses1>
<us-gaap:AvailableForSaleSecuritiesGrossUnrealizedLosses1 id="Tag267" decimals="-3" contextRef="I2012_CorporateBondSecuritiesMember" unitRef="USD"> 1000 </us-gaap:AvailableForSaleSecuritiesGrossUnrealizedLosses1>
<us-gaap:AvailableForSaleSecuritiesFairValueDisclosure id="Tag268" decimals="-3" contextRef="I2012_FairValueInputsLevel2Member" unitRef="USD"> 30924000 </us-gaap:AvailableForSaleSecuritiesFairValueDisclosure>
<us-gaap:AvailableForSaleSecuritiesFairValueDisclosure id="Tag269" decimals="-3" contextRef="I2012_FairValueInputsLevel2Member_AssetBackedSecuritiesMember" unitRef="USD"> 6053000 </us-gaap:AvailableForSaleSecuritiesFairValueDisclosure>
<us-gaap:AvailableForSaleSecuritiesFairValueDisclosure id="Tag270" decimals="-3" contextRef="I2012_CommercialPaperMember_FairValueInputsLevel2Member" unitRef="USD"> 15997000 </us-gaap:AvailableForSaleSecuritiesFairValueDisclosure>
<us-gaap:AvailableForSaleSecuritiesFairValueDisclosure id="Tag271" decimals="-3" contextRef="I2012_CorporateBondSecuritiesMember_FairValueInputsLevel2Member" unitRef="USD"> 8874000 </us-gaap:AvailableForSaleSecuritiesFairValueDisclosure>
<pcrx:NumberOfMajorCustomers id="Tag272" decimals="INF" contextRef="D2012" unitRef="Item"> 4 </pcrx:NumberOfMajorCustomers>
<us-gaap:ConcentrationRiskPercentage1 id="Tag273" decimals="2" contextRef="D2012_AccountsReceivableMember_CreditConcentrationRiskMember_MajorCustomerOneMember" unitRef="Pure"> 0.31 </us-gaap:ConcentrationRiskPercentage1>
<us-gaap:ConcentrationRiskPercentage1 id="Tag274" decimals="2" contextRef="D2012_AccountsReceivableMember_CreditConcentrationRiskMember_MajorCustomerTwoMember" unitRef="Pure"> 0.27 </us-gaap:ConcentrationRiskPercentage1>
<us-gaap:ImpairmentOfLongLivedAssetsHeldForUse id="Tag275" decimals="-5" contextRef="D2011_ComputerEquipmentAndSoftwareMember" unitRef="USD"> 1300000 </us-gaap:ImpairmentOfLongLivedAssetsHeldForUse>
<us-gaap:ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock id="Tag276" contextRef="D2012">
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"> <p style="FONT-FAMILY: times"><font size="2">The following table sets forth the computation of basic and diluted loss per share for the years ended December 31, 2012, 2011 and 2010 (in thousands except per share amounts):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table style="WIDTH: 775px; HEIGHT: 86px" cellspacing="0" cellpadding="0" width="775" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="64"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="64"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="64"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="8"><font size="1"><b>Year Ended</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br /> 2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br /> 2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br /> 2010</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2"><b>Numerator:</b></font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="white"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Net loss</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(52,281</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(43,328</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(27,149</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2"><b>Denominator:</b></font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="white"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Weighted average shares of common stock outstanding</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">30,332</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">16,437</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">574</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2"><b>Net loss per share</b></font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="white"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Basic and diluted net loss per share of common stock</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(1.72</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(2.64</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(47.29</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
</us-gaap:ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock>
<us-gaap:ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock id="Tag277" contextRef="D2012">
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"> <p style="FONT-FAMILY: times"><font size="2">The potential dilutive effect of these securities is shown in the chart below (in thousands):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 89.44%; PADDING-TOP: 0pt; POSITION: relative; HEIGHT: 44px"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="100%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="64"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="64"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="64"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="8"><font size="1"><b>Year Ended</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br /> 2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br /> 2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br /> 2010</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Convertible series A preferred stock</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">6,323</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Stock options</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,276</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,177</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,058</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Convertible debt</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,425</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Warrants</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">161</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">110</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">80</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,437</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,287</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">8,886</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
</us-gaap:ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock>
<us-gaap:WeightedAverageNumberOfSharesOutstandingBasic id="Tag278" decimals="-3" contextRef="D2012" unitRef="Shares"> 30332000 </us-gaap:WeightedAverageNumberOfSharesOutstandingBasic>
<us-gaap:WeightedAverageNumberOfSharesOutstandingBasic id="Tag279" decimals="-3" contextRef="D2011" unitRef="Shares"> 16437000 </us-gaap:WeightedAverageNumberOfSharesOutstandingBasic>
<us-gaap:WeightedAverageNumberOfSharesOutstandingBasic id="Tag280" decimals="-3" contextRef="D2010" unitRef="Shares"> 574000 </us-gaap:WeightedAverageNumberOfSharesOutstandingBasic>
<us-gaap:RoyaltyRevenue id="Tag281" decimals="-3" contextRef="D2011" unitRef="USD"> 3720000 </us-gaap:RoyaltyRevenue>
<us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount id="Tag282" decimals="-3" contextRef="D2012_StockOptionsMember" unitRef="Shares"> 1276000 </us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount>
<us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount id="Tag283" decimals="-3" contextRef="D2012_WarrantMember" unitRef="Shares"> 161000 </us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount>
<us-gaap:ScheduleOfInventoryCurrentTableTextBlock id="Tag284" contextRef="D2012">
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"> <p style="FONT-FAMILY: times"><font size="2">The components of inventories were as follows (in thousands):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative; HEIGHT: 50px"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table style="WIDTH: 645px; HEIGHT: 152px" cellspacing="0" cellpadding="0" width="645" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="39"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="5"><font size="1"><b>December 31,</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Raw materials</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">4,081</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">862</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Work-in-process</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,979</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">96</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Finished goods</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,017</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">287</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">12,077</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,245</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
</us-gaap:ScheduleOfInventoryCurrentTableTextBlock>
<us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount id="Tag285" decimals="-3" contextRef="D2011_StockOptionsMember" unitRef="Shares"> 1177000 </us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount>
<us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount id="Tag286" decimals="-3" contextRef="D2011_WarrantMember" unitRef="Shares"> 110000 </us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount>
<us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount id="Tag287" decimals="-3" contextRef="D2010_SeriesAPreferredStockMember" unitRef="Shares"> 6323000 </us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount>
<us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount id="Tag288" decimals="-3" contextRef="D2010_StockOptionsMember" unitRef="Shares"> 1058000 </us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount>
<us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount id="Tag289" decimals="-3" contextRef="D2010_ConvertibleDebtSecuritiesMember" unitRef="Shares"> 1425000 </us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount>
<us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount id="Tag290" decimals="-3" contextRef="D2010_WarrantMember" unitRef="Shares"> 80000 </us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount>
<us-gaap:InventoryRawMaterialsNetOfReserves id="Tag291" decimals="-3" contextRef="I2011" unitRef="USD"> 862000 </us-gaap:InventoryRawMaterialsNetOfReserves>
<us-gaap:InventoryRawMaterialsNetOfReserves id="Tag292" decimals="-3" contextRef="I2012" unitRef="USD"> 4081000 </us-gaap:InventoryRawMaterialsNetOfReserves>
<us-gaap:InventoryWorkInProcessNetOfReserves id="Tag293" decimals="-3" contextRef="I2011" unitRef="USD"> 96000 </us-gaap:InventoryWorkInProcessNetOfReserves>
<us-gaap:InventoryWorkInProcessNetOfReserves id="Tag294" decimals="-3" contextRef="I2012" unitRef="USD"> 5979000 </us-gaap:InventoryWorkInProcessNetOfReserves>
<us-gaap:InventoryFinishedGoodsNetOfReserves id="Tag295" decimals="-3" contextRef="I2011" unitRef="USD"> 287000 </us-gaap:InventoryFinishedGoodsNetOfReserves>
<us-gaap:InventoryFinishedGoodsNetOfReserves id="Tag296" decimals="-3" contextRef="I2012" unitRef="USD"> 2017000 </us-gaap:InventoryFinishedGoodsNetOfReserves>
<us-gaap:InventoryNet id="Tag297" decimals="-3" contextRef="I2012" unitRef="USD"> 12077000 </us-gaap:InventoryNet>
<pcrx:ScheduleOfPropertyPlantAndEquipmentComponentsTableTextBlock id="Tag298" contextRef="D2012">
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"> <p style="FONT-FAMILY: times"><font size="2">Fixed assets, at cost, summarized by major category, consist of the following (in thousands):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table style="WIDTH: 763px; HEIGHT: 85px" cellspacing="0" cellpadding="0" width="763" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="50"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="5"><font size="1"><b>December 31,</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Machinery and laboratory equipment</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">12,414</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">12,188</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Computer equipment and software</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,579</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,133</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Office furniture and equipment</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">437</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">352</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Leasehold improvements</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">6,217</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">6,056</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Construction in progress</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">30,072</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">13,656</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">50,719</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">33,385</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Less accumulated depreciation</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(11,603</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(8,282</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 30pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Fixed assets, net</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">39,116</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">25,103</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
</pcrx:ScheduleOfPropertyPlantAndEquipmentComponentsTableTextBlock>
<us-gaap:PropertyPlantAndEquipmentGross id="Tag299" decimals="-3" contextRef="I2011_MachineryAndEquipmentMember" unitRef="USD"> 12188000 </us-gaap:PropertyPlantAndEquipmentGross>
<us-gaap:PropertyPlantAndEquipmentGross id="Tag300" decimals="-3" contextRef="I2011_ComputerEquipmentAndSoftwareMember" unitRef="USD"> 1133000 </us-gaap:PropertyPlantAndEquipmentGross>
<us-gaap:PropertyPlantAndEquipmentGross id="Tag301" decimals="-3" contextRef="I2011_FurnitureAndFixturesMember" unitRef="USD"> 352000 </us-gaap:PropertyPlantAndEquipmentGross>
<us-gaap:PropertyPlantAndEquipmentGross id="Tag302" decimals="-3" contextRef="I2011_LeaseholdImprovementsMember" unitRef="USD"> 6056000 </us-gaap:PropertyPlantAndEquipmentGross>
<us-gaap:PropertyPlantAndEquipmentGross id="Tag303" decimals="-3" contextRef="I2011_ConstructionInProgressMember" unitRef="USD"> 13656000 </us-gaap:PropertyPlantAndEquipmentGross>
<us-gaap:PropertyPlantAndEquipmentGross id="Tag304" decimals="-3" contextRef="I2011" unitRef="USD"> 33385000 </us-gaap:PropertyPlantAndEquipmentGross>
<us-gaap:InterestPaid id="Tag305" decimals="-3" contextRef="D2011" unitRef="USD"> 4739000 </us-gaap:InterestPaid>
<us-gaap:PropertyPlantAndEquipmentGross id="Tag306" decimals="-3" contextRef="I2012_MachineryAndEquipmentMember" unitRef="USD"> 12414000 </us-gaap:PropertyPlantAndEquipmentGross>
<us-gaap:PropertyPlantAndEquipmentGross id="Tag307" decimals="-3" contextRef="I2012_ComputerEquipmentAndSoftwareMember" unitRef="USD"> 1579000 </us-gaap:PropertyPlantAndEquipmentGross>
<us-gaap:PropertyPlantAndEquipmentGross id="Tag308" decimals="-3" contextRef="I2012_FurnitureAndFixturesMember" unitRef="USD"> 437000 </us-gaap:PropertyPlantAndEquipmentGross>
<us-gaap:PropertyPlantAndEquipmentGross id="Tag309" decimals="-3" contextRef="I2012_LeaseholdImprovementsMember" unitRef="USD"> 6217000 </us-gaap:PropertyPlantAndEquipmentGross>
<us-gaap:PropertyPlantAndEquipmentGross id="Tag310" decimals="-3" contextRef="I2012_ConstructionInProgressMember" unitRef="USD"> 30072000 </us-gaap:PropertyPlantAndEquipmentGross>
<us-gaap:PropertyPlantAndEquipmentGross id="Tag311" decimals="-3" contextRef="I2012" unitRef="USD"> 50719000 </us-gaap:PropertyPlantAndEquipmentGross>
<us-gaap:AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment id="Tag312" decimals="-3" contextRef="I2011" unitRef="USD"> 8282000 </us-gaap:AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment>
<us-gaap:AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment id="Tag313" decimals="-3" contextRef="I2012" unitRef="USD"> 11603000 </us-gaap:AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment>
<us-gaap:PropertyPlantAndEquipmentNet id="Tag314" decimals="-3" contextRef="I2012" unitRef="USD"> 39116000 </us-gaap:PropertyPlantAndEquipmentNet>
<us-gaap:Depreciation id="Tag315" decimals="-5" contextRef="D2012" unitRef="USD"> 3600000 </us-gaap:Depreciation>
<us-gaap:Depreciation id="Tag316" decimals="-5" contextRef="D2011" unitRef="USD"> 2000000 </us-gaap:Depreciation>
<us-gaap:Depreciation id="Tag317" decimals="-5" contextRef="D2010" unitRef="USD"> 1800000 </us-gaap:Depreciation>
<us-gaap:ImpairmentOfLongLivedAssetsHeldForUse id="Tag318" decimals="-5" contextRef="D2011_DepoDurMember" unitRef="USD"> 300000 </us-gaap:ImpairmentOfLongLivedAssetsHeldForUse>
<us-gaap:InterestCostsCapitalized id="Tag319" decimals="-5" contextRef="D2011" unitRef="USD"> 800000 </us-gaap:InterestCostsCapitalized>
<us-gaap:ScheduleOfFiniteLivedIntangibleAssetsTableTextBlock id="Tag320" contextRef="D2012">
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"> <p style="FONT-FAMILY: times"><font size="2">Intangible assets, net consist of core technology, developed technology and trademarks and trade names acquired in the Acquisition as follows (in thousands):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table style="WIDTH: 741px; HEIGHT: 64px" cellspacing="0" cellpadding="0" width="741" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="18"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="18"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="center" width="53"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="5"><font size="1"><b>Year Ended</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times" rowspan="2"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="5" rowspan="2"><font size="1"><b>December 31,</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times" rowspan="2"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" rowspan="2"><font size="1"><b>Estimated<br /> Useful Life</b></font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Core Technology</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Gross amount</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,900</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,900</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">9 years</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Accumulated amortization</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(1,853</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(1,530</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom" align="center"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 30pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Net</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,047</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,370</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom" align="center"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Developed Technology</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Gross amount</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">11,700</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">11,700</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">7 years</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Accumulated amortization</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(9,610</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(7,939</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom" align="center"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 30pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Net</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,090</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,761</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom" align="center"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Trademarks and trade names</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Gross amount</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">400</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">400</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">7 years</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Accumulated amortization</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(329</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(272</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom" align="center"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 30pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Net</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">71</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">128</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom" align="center"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Intangible assets, net</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,208</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,259</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom" align="center"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
</us-gaap:ScheduleOfFiniteLivedIntangibleAssetsTableTextBlock>
<us-gaap:ScheduleofFiniteLivedIntangibleAssetsFutureAmortizationExpenseTableTextBlock id="Tag321" contextRef="D2012">
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"> <p style="FONT-FAMILY: times"><font size="2">The approximate amortization expense for intangibles subject to amortization is as follows (in thousands):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table style="WIDTH: 695px; HEIGHT: 41px" cellspacing="0" cellpadding="0" width="695" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="53"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="53"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="58"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="39"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Core<br /> Technology</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Developed<br /> Technology</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Trademarks<br /> and<br /> Tradenames</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Total</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2013</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">322</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,671</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">57</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,050</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2014</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">322</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">419</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">14</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">755</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2015</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">322</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">322</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2016</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">81</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">81</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,047</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,090</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">71</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,208</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
</us-gaap:ScheduleofFiniteLivedIntangibleAssetsFutureAmortizationExpenseTableTextBlock>
<us-gaap:FiniteLivedIntangibleAssetsGross id="Tag322" decimals="-3" contextRef="I2012_CoreTechnologyMember" unitRef="USD"> 2900000 </us-gaap:FiniteLivedIntangibleAssetsGross>
<us-gaap:FiniteLivedIntangibleAssetsGross id="Tag323" decimals="-3" contextRef="I2012_DevelopedTechnologyRightsMember" unitRef="USD"> 11700000 </us-gaap:FiniteLivedIntangibleAssetsGross>
<us-gaap:FiniteLivedIntangibleAssetsGross id="Tag324" decimals="-3" contextRef="I2012_TrademarksAndTradeNamesMember" unitRef="USD"> 400000 </us-gaap:FiniteLivedIntangibleAssetsGross>
<us-gaap:FiniteLivedIntangibleAssetsGross id="Tag325" decimals="-3" contextRef="I2011_CoreTechnologyMember" unitRef="USD"> 2900000 </us-gaap:FiniteLivedIntangibleAssetsGross>
<us-gaap:FiniteLivedIntangibleAssetsGross id="Tag326" decimals="-3" contextRef="I2011_DevelopedTechnologyRightsMember" unitRef="USD"> 11700000 </us-gaap:FiniteLivedIntangibleAssetsGross>
<us-gaap:FiniteLivedIntangibleAssetsGross id="Tag327" decimals="-3" contextRef="I2011_TrademarksAndTradeNamesMember" unitRef="USD"> 400000 </us-gaap:FiniteLivedIntangibleAssetsGross>
<us-gaap:FiniteLivedIntangibleAssetUsefulLife id="Tag328" contextRef="D2012_CoreTechnologyMember"> P9Y </us-gaap:FiniteLivedIntangibleAssetUsefulLife>
<us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization id="Tag329" decimals="-3" contextRef="I2012_CoreTechnologyMember" unitRef="USD"> 1853000 </us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization>
<us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization id="Tag330" decimals="-3" contextRef="I2012_DevelopedTechnologyRightsMember" unitRef="USD"> 9610000 </us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization>
<us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization id="Tag331" decimals="-3" contextRef="I2012_TrademarksAndTradeNamesMember" unitRef="USD"> 329000 </us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization>
<us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization id="Tag332" decimals="-3" contextRef="I2011_CoreTechnologyMember" unitRef="USD"> 1530000 </us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization>
<us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization id="Tag333" decimals="-3" contextRef="I2011_DevelopedTechnologyRightsMember" unitRef="USD"> 7939000 </us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization>
<us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization id="Tag334" decimals="-3" contextRef="I2011_TrademarksAndTradeNamesMember" unitRef="USD"> 272000 </us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization>
<us-gaap:FiniteLivedIntangibleAssetUsefulLife id="Tag335" contextRef="D2012_DevelopedTechnologyRightsMember"> P7Y </us-gaap:FiniteLivedIntangibleAssetUsefulLife>
<us-gaap:FiniteLivedIntangibleAssetsNet id="Tag336" decimals="-3" contextRef="I2012_CoreTechnologyMember" unitRef="USD"> 1047000 </us-gaap:FiniteLivedIntangibleAssetsNet>
<us-gaap:FiniteLivedIntangibleAssetsNet id="Tag337" decimals="-3" contextRef="I2012_DevelopedTechnologyRightsMember" unitRef="USD"> 2090000 </us-gaap:FiniteLivedIntangibleAssetsNet>
<us-gaap:FiniteLivedIntangibleAssetsNet id="Tag338" decimals="-3" contextRef="I2012_TrademarksAndTradeNamesMember" unitRef="USD"> 71000 </us-gaap:FiniteLivedIntangibleAssetsNet>
<us-gaap:FiniteLivedIntangibleAssetsNet id="Tag339" decimals="-3" contextRef="I2011_CoreTechnologyMember" unitRef="USD"> 1370000 </us-gaap:FiniteLivedIntangibleAssetsNet>
<us-gaap:FiniteLivedIntangibleAssetsNet id="Tag340" decimals="-3" contextRef="I2011_DevelopedTechnologyRightsMember" unitRef="USD"> 3761000 </us-gaap:FiniteLivedIntangibleAssetsNet>
<us-gaap:FiniteLivedIntangibleAssetsNet id="Tag341" decimals="-3" contextRef="I2011_TrademarksAndTradeNamesMember" unitRef="USD"> 128000 </us-gaap:FiniteLivedIntangibleAssetsNet>
<us-gaap:FiniteLivedIntangibleAssetUsefulLife id="Tag342" contextRef="D2012_TrademarksAndTradeNamesMember"> P7Y </us-gaap:FiniteLivedIntangibleAssetUsefulLife>
<us-gaap:FiniteLivedIntangibleAssetsNet id="Tag343" decimals="-3" contextRef="I2012" unitRef="USD"> 3208000 </us-gaap:FiniteLivedIntangibleAssetsNet>
<us-gaap:AmortizationOfIntangibleAssets id="Tag344" decimals="-5" contextRef="D2012" unitRef="USD"> 2100000 </us-gaap:AmortizationOfIntangibleAssets>
<us-gaap:AmortizationOfIntangibleAssets id="Tag345" decimals="-5" contextRef="D2011" unitRef="USD"> 2300000 </us-gaap:AmortizationOfIntangibleAssets>
<us-gaap:AmortizationOfIntangibleAssets id="Tag346" decimals="-5" contextRef="D2010" unitRef="USD"> 2300000 </us-gaap:AmortizationOfIntangibleAssets>
<us-gaap:ImpairmentOfLongLivedAssetsHeldForUse id="Tag347" decimals="-5" contextRef="D2011Q4_M12_DepoDurRightsMember" unitRef="USD"> 1400000 </us-gaap:ImpairmentOfLongLivedAssetsHeldForUse>
<us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths id="Tag348" decimals="-3" contextRef="I2012_CoreTechnologyMember" unitRef="USD"> 322000 </us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths>
<us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths id="Tag349" decimals="-3" contextRef="I2012_DevelopedTechnologyRightsMember" unitRef="USD"> 1671000 </us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths>
<us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths id="Tag350" decimals="-3" contextRef="I2012_TrademarksAndTradeNamesMember" unitRef="USD"> 57000 </us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths>
<us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths id="Tag351" decimals="-3" contextRef="I2012" unitRef="USD"> 2050000 </us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths>
<us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo id="Tag352" decimals="-3" contextRef="I2012_CoreTechnologyMember" unitRef="USD"> 322000 </us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo>
<us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo id="Tag353" decimals="-3" contextRef="I2012_DevelopedTechnologyRightsMember" unitRef="USD"> 419000 </us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo>
<us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo id="Tag354" decimals="-3" contextRef="I2012_TrademarksAndTradeNamesMember" unitRef="USD"> 14000 </us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo>
<us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo id="Tag355" decimals="-3" contextRef="I2012" unitRef="USD"> 755000 </us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo>
<us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearThree id="Tag356" decimals="-3" contextRef="I2012_CoreTechnologyMember" unitRef="USD"> 322000 </us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearThree>
<us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearThree id="Tag357" decimals="-3" contextRef="I2012" unitRef="USD"> 322000 </us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearThree>
<us-gaap:EmployeeRelatedLiabilitiesCurrent id="Tag358" decimals="-3" contextRef="I2011" unitRef="USD"> 2824000 </us-gaap:EmployeeRelatedLiabilitiesCurrent>
<us-gaap:EmployeeRelatedLiabilitiesCurrent id="Tag359" decimals="-3" contextRef="I2012" unitRef="USD"> 1635000 </us-gaap:EmployeeRelatedLiabilitiesCurrent>
<pcrx:AccruedOperatingExpensesCurrent id="Tag360" decimals="-3" contextRef="I2012" unitRef="USD"> 5924000 </pcrx:AccruedOperatingExpensesCurrent>
<us-gaap:AccruedRoyaltiesCurrent id="Tag361" decimals="-3" contextRef="I2012" unitRef="USD"> 360000 </us-gaap:AccruedRoyaltiesCurrent>
<us-gaap:AccruedLiabilitiesCurrent id="Tag362" decimals="-3" contextRef="I2012" unitRef="USD"> 9792000 </us-gaap:AccruedLiabilitiesCurrent>
<pcrx:AccruedOperatingExpensesCurrent id="Tag363" decimals="-3" contextRef="I2011" unitRef="USD"> 3090000 </pcrx:AccruedOperatingExpensesCurrent>
<us-gaap:AccruedRoyaltiesCurrent id="Tag364" decimals="-3" contextRef="I2011" unitRef="USD"> 345000 </us-gaap:AccruedRoyaltiesCurrent>
<us-gaap:ScheduleOfAccruedLiabilitiesTableTextBlock id="Tag365" contextRef="D2012">
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"> <p style="FONT-FAMILY: times"><font size="2">Accrued expenses consist of the following (in thousands):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 78.5%; PADDING-TOP: 0pt; POSITION: relative; HEIGHT: 68px"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table style="WIDTH: 680px; HEIGHT: 80px" cellspacing="0" cellpadding="0" width="680" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="18"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="39"></td> <td style="FONT-FAMILY: times" width="18"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="39"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="5"><font size="1"><b>December 31,</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Compensation and benefits</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,635</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,824</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Accrued operating expenses</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,924</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,090</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Accrued royalties</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">360</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">345</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Accrued interest and end of term fee</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,873</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">900</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">9,792</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">7,159</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
</us-gaap:ScheduleOfAccruedLiabilitiesTableTextBlock>
<us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount id="Tag366" decimals="-3" contextRef="D2011" unitRef="Shares"> 1287000 </us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount>
<us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount id="Tag367" decimals="-3" contextRef="D2010" unitRef="Shares"> 8886000 </us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount>
<us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount id="Tag368" decimals="-3" contextRef="D2012" unitRef="Shares"> 1437000 </us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount>
<us-gaap:PaymentsOfStockIssuanceCosts id="Tag369" decimals="-3" contextRef="D2011" unitRef="USD"> 907000 </us-gaap:PaymentsOfStockIssuanceCosts>
<us-gaap:DebtConversionConvertedInstrumentAmount1 id="Tag370" decimals="-3" contextRef="D2011" unitRef="USD"> 51222000 </us-gaap:DebtConversionConvertedInstrumentAmount1>
<us-gaap:ConversionOfStockAmountConverted1 id="Tag371" decimals="-3" contextRef="D2011" unitRef="USD"> 6000 </us-gaap:ConversionOfStockAmountConverted1>
<us-gaap:ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock id="Tag372" contextRef="D2012">
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"> <p style="FONT-FAMILY: times"><font size="2"> The Company recognized stock-based compensation in its consolidated statements of operations for the years ended December 31, 2012, 2011 and 2010 as follows (in thousands):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table style="WIDTH: 701px; HEIGHT: 27px" cellspacing="0" cellpadding="0" width="701" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="39"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="39"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="25"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="8"><font size="1"><b>Year Ended December 31,</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2010</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Cost of revenues</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">563</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">218</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">12</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Research and development</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,155</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">804</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">10</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Selling, general and administrative</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,058</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,471</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">4,776</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,493</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">23</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
</us-gaap:ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock>
<pcrx:ScheduleOfSharesAvailableForIssuanceTableTextBlock id="Tag373" contextRef="D2012">
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"> <p style="FONT-FAMILY: times"><font size="2">The following table contains information about the Company's plans at December 31, 2012:</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table style="WIDTH: 759px; HEIGHT: 20px" cellspacing="0" cellpadding="0" width="759" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="79"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="68"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="79"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" nowrap="nowrap" align="left"> <div style="MARGIN-BOTTOM: 0pt; WIDTH: 16pt; BORDER-BOTTOM: #000000 1pt solid"><font size="1"><b>Plan <!-- COMMAND=ADD_SCROPPEDRULE,16pt --></b></font></div></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Awards Reserved<br /> for Issuance</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Awards Issued</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Awards Available<br /> for Grant</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2011 Plan</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,138,519</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,393,214</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">745,305</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2007 Plan</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,066,018</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,066,018</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"> </p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,204,537</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">4,459,232</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">745,305</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
</pcrx:ScheduleOfSharesAvailableForIssuanceTableTextBlock>
<us-gaap:StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities id="Tag374" decimals="INF" contextRef="D2011Q1_M0208_SeriesAPreferredStockMember" unitRef="Shares"> 6322640 </us-gaap:StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities>
<pcrx:CostOfRevenuesTableTextBlock id="Tag375" contextRef="D2012">
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"> <p style="FONT-FAMILY: times"><font size="2">Cost of revenues consists of the following (in thousands):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 85.55%; PADDING-TOP: 0pt; POSITION: relative; HEIGHT: 62px"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table style="WIDTH: 814px; HEIGHT: 42px" cellspacing="0" cellpadding="0" width="814" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="8"><font size="1"><b>Year Ended December 31,</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2010</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Cost of goods sold</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">31,744</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">15,310</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">11,374</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Cost of collaborative licensing and development</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">395</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,429</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">902</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total cost of revenues</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">32,139</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">16,739</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">12,276</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
</pcrx:CostOfRevenuesTableTextBlock>
<us-gaap:ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock id="Tag376" contextRef="D2012">
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"> </p> <div align="center"> <table style="WIDTH: 751px; HEIGHT: 37px" cellspacing="0" cellpadding="0" width="751" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="37"></td> <td style="FONT-FAMILY: times" width="16"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="37"></td> <td style="FONT-FAMILY: times" width="16"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="37"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="8"><font size="1"><b>Year Ended December 31,</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2010</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Benefit at U.S. Federal statutory rate</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">35.00</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">35.00</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">35.00</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">State taxes—deferred</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">6.73</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3.98</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">7.75</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Increase in valuation allowance</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(39.62</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(38.27</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(44.77</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)%</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Tax credits</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">0.00</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">0.13</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">0.18</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Other</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(2.11</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(0.84</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1.84</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Provision for income taxes</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">0.00</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">0.00</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">0.00</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
</us-gaap:ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock>
<us-gaap:ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock id="Tag377" contextRef="D2012">
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"> <p style="FONT-FAMILY: times"><font size="2">Significant components of the Company's deferred tax assets are as follows (in thousands):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table style="WIDTH: 797px; HEIGHT: 9px" cellspacing="0" cellpadding="0" width="797" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="56"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="50"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="5"><font size="1"><b>December 31,</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Deferred tax assets:</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Federal and state net operating loss carry-forwards</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">89,150</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">62,231</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Federal and state research credits</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,631</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,395</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Depreciation and amortization</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,891</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">4,867</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Accruals and reserves</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,388</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,685</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Deferred revenue</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,897</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">8,745</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Other</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,997</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,325</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total gross deferred tax assets</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">103,954</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">83,248</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Less valuation allowance for deferred tax assets</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(103,954</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(83,248</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Net deferred tax assets</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
</us-gaap:ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock>
<us-gaap:ScheduleOfUnrecognizedTaxBenefitsRollForwardTableTextBlock id="Tag378" contextRef="D2012">
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 80.08%; PADDING-TOP: 0pt; POSITION: relative; HEIGHT: 29px"> <p style="FONT-FAMILY: times"> </p> <div align="center"> <table style="WIDTH: 721px; HEIGHT: 152px" cellspacing="0" cellpadding="0" width="721" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="30"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="30"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="5"><font size="1"><b>Year Ended<br /> December 31,</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Balance at beginning of year</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">420</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">420</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Increases related to tax positions taken during the current year</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Increases related to tax positions taken during a prior period</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Balance at end of year</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">420</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">420</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
</us-gaap:ScheduleOfUnrecognizedTaxBenefitsRollForwardTableTextBlock>
<us-gaap:ScheduleOfFutureMinimumRentalPaymentsForOperatingLeasesTableTextBlock id="Tag379" contextRef="D2012">
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"> <p style="FONT-FAMILY: times"><font size="2">As of December 31, 2012, annual minimum payments due under the Company's lease obligations are as follows (in thousands):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table style="WIDTH: 611px; HEIGHT: 72px" cellspacing="0" cellpadding="0" width="611" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" nowrap="nowrap" align="left"> <div style="MARGIN-BOTTOM: 0pt; WIDTH: 16pt; BORDER-BOTTOM: #000000 1pt solid"><font size="1"><b>Year <!-- COMMAND=ADD_SCROPPEDRULE,16pt --></b></font></div></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="FONT-FAMILY: times" align="center" colspan="2"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2013</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,284</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2014</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">5,463</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2015</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">3,464</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2016</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">405</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2017</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">201</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">14,817</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
</us-gaap:ScheduleOfFutureMinimumRentalPaymentsForOperatingLeasesTableTextBlock>
<us-gaap:CostOfGoodsSold id="Tag380" decimals="-3" contextRef="D2012" unitRef="USD"> 31744000 </us-gaap:CostOfGoodsSold>
<us-gaap:CostOfGoodsSold id="Tag381" decimals="-3" contextRef="D2010" unitRef="USD"> 11374000 </us-gaap:CostOfGoodsSold>
<us-gaap:CostOfGoodsSold id="Tag382" decimals="-3" contextRef="D2011" unitRef="USD"> 15310000 </us-gaap:CostOfGoodsSold>
<us-gaap:CostOfServicesLicensesAndServices id="Tag383" decimals="-3" contextRef="D2012" unitRef="USD"> 395000 </us-gaap:CostOfServicesLicensesAndServices>
<us-gaap:CostOfServicesLicensesAndServices id="Tag384" decimals="-3" contextRef="D2010" unitRef="USD"> 902000 </us-gaap:CostOfServicesLicensesAndServices>
<us-gaap:CostOfServicesLicensesAndServices id="Tag385" decimals="-3" contextRef="D2011" unitRef="USD"> 1429000 </us-gaap:CostOfServicesLicensesAndServices>
<us-gaap:CostOfRevenue id="Tag386" decimals="-3" contextRef="D2012" unitRef="USD"> 32139000 </us-gaap:CostOfRevenue>
<us-gaap:DeferredTaxAssetsOperatingLossCarryforwards id="Tag387" decimals="-3" contextRef="I2011" unitRef="USD"> 62231000 </us-gaap:DeferredTaxAssetsOperatingLossCarryforwards>
<us-gaap:DeferredTaxAssetsTaxCreditCarryforwardsResearch id="Tag388" decimals="-3" contextRef="I2011" unitRef="USD"> 3395000 </us-gaap:DeferredTaxAssetsTaxCreditCarryforwardsResearch>
<us-gaap:DeferredTaxAssetsPropertyPlantAndEquipment id="Tag389" decimals="-3" contextRef="I2011" unitRef="USD"> 4867000 </us-gaap:DeferredTaxAssetsPropertyPlantAndEquipment>
<us-gaap:DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals id="Tag390" decimals="-3" contextRef="I2011" unitRef="USD"> 2685000 </us-gaap:DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals>
<us-gaap:DeferredTaxAssetsDeferredIncome id="Tag391" decimals="-3" contextRef="I2011" unitRef="USD"> 8745000 </us-gaap:DeferredTaxAssetsDeferredIncome>
<us-gaap:DeferredTaxAssetsOther id="Tag392" decimals="-3" contextRef="I2011" unitRef="USD"> 1325000 </us-gaap:DeferredTaxAssetsOther>
<us-gaap:DeferredTaxAssetsGross id="Tag393" decimals="-3" contextRef="I2011" unitRef="USD"> 83248000 </us-gaap:DeferredTaxAssetsGross>
<us-gaap:DeferredTaxAssetsValuationAllowance id="Tag394" decimals="-3" contextRef="I2011" unitRef="USD"> 83248000 </us-gaap:DeferredTaxAssetsValuationAllowance>
<us-gaap:DeferredTaxAssetsOperatingLossCarryforwards id="Tag395" decimals="-3" contextRef="I2012" unitRef="USD"> 89150000 </us-gaap:DeferredTaxAssetsOperatingLossCarryforwards>
<us-gaap:DeferredTaxAssetsTaxCreditCarryforwardsResearch id="Tag396" decimals="-3" contextRef="I2012" unitRef="USD"> 3631000 </us-gaap:DeferredTaxAssetsTaxCreditCarryforwardsResearch>
<us-gaap:DeferredTaxAssetsPropertyPlantAndEquipment id="Tag397" decimals="-3" contextRef="I2012" unitRef="USD"> 3891000 </us-gaap:DeferredTaxAssetsPropertyPlantAndEquipment>
<us-gaap:DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals id="Tag398" decimals="-3" contextRef="I2012" unitRef="USD"> 3388000 </us-gaap:DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals>
<us-gaap:DeferredTaxAssetsDeferredIncome id="Tag399" decimals="-3" contextRef="I2012" unitRef="USD"> 1897000 </us-gaap:DeferredTaxAssetsDeferredIncome>
<us-gaap:DeferredTaxAssetsOther id="Tag400" decimals="-3" contextRef="I2012" unitRef="USD"> 1997000 </us-gaap:DeferredTaxAssetsOther>
<us-gaap:DeferredTaxAssetsGross id="Tag401" decimals="-3" contextRef="I2012" unitRef="USD"> 103954000 </us-gaap:DeferredTaxAssetsGross>
<us-gaap:DeferredTaxAssetsValuationAllowance id="Tag402" decimals="-3" contextRef="I2012" unitRef="USD"> 103954000 </us-gaap:DeferredTaxAssetsValuationAllowance>
<us-gaap:ValuationAllowanceDeferredTaxAssetChangeInAmount id="Tag403" decimals="-5" contextRef="D2011" unitRef="USD"> 16600000 </us-gaap:ValuationAllowanceDeferredTaxAssetChangeInAmount>
<us-gaap:ValuationAllowanceDeferredTaxAssetChangeInAmount id="Tag404" decimals="-5" contextRef="D2010" unitRef="USD"> 12200000 </us-gaap:ValuationAllowanceDeferredTaxAssetChangeInAmount>
<us-gaap:ValuationAllowanceDeferredTaxAssetChangeInAmount id="Tag405" decimals="-5" contextRef="D2012" unitRef="USD"> 20700000 </us-gaap:ValuationAllowanceDeferredTaxAssetChangeInAmount>
<us-gaap:OperatingLossCarryforwards id="Tag406" decimals="-5" contextRef="I2012_InternalRevenueServiceIRSMember" unitRef="USD"> 219200000 </us-gaap:OperatingLossCarryforwards>
<us-gaap:OperatingLossCarryforwards id="Tag407" decimals="-5" contextRef="I2012_StateAndLocalJurisdictionMember" unitRef="USD"> 216100000 </us-gaap:OperatingLossCarryforwards>
<us-gaap:TaxCreditCarryforwardAmount id="Tag408" decimals="-5" contextRef="I2012_InternalRevenueServiceIRSMember_ResearchMember" unitRef="USD"> 2600000 </us-gaap:TaxCreditCarryforwardAmount>
<us-gaap:TaxCreditCarryforwardAmount id="Tag409" decimals="-5" contextRef="I2012_StateAndLocalJurisdictionMember_ResearchMember" unitRef="USD"> 1600000 </us-gaap:TaxCreditCarryforwardAmount>
<pcrx:MinimumCumulativePercentageOfChangeInOwnershipAsConditionToOffsetTaxableIncomeOrTax id="Tag410" decimals="2" contextRef="D2012" unitRef="Pure"> 0.50 </pcrx:MinimumCumulativePercentageOfChangeInOwnershipAsConditionToOffsetTaxableIncomeOrTax>
<pcrx:PeriodWithinWhichCumulativePercentageOfChangeInOwnershipOccursAsConditionToOffsetTaxableIncomeOrTax id="Tag411" contextRef="D2012"> P3Y </pcrx:PeriodWithinWhichCumulativePercentageOfChangeInOwnershipOccursAsConditionToOffsetTaxableIncomeOrTax>
<us-gaap:UnrecognizedTaxBenefits id="Tag412" decimals="-3" contextRef="I2011" unitRef="USD"> 420000 </us-gaap:UnrecognizedTaxBenefits>
<us-gaap:UnrecognizedTaxBenefits id="Tag413" decimals="-3" contextRef="I2010" unitRef="USD"> 420000 </us-gaap:UnrecognizedTaxBenefits>
<us-gaap:UnrecognizedTaxBenefits id="Tag414" decimals="-3" contextRef="I2012" unitRef="USD"> 420000 </us-gaap:UnrecognizedTaxBenefits>
<us-gaap:DefinedContributionPlanCostRecognized id="Tag415" decimals="-5" contextRef="D2011" unitRef="USD"> 200000 </us-gaap:DefinedContributionPlanCostRecognized>
<pcrx:CollaborativeArrangementUpfrontPaymentReceived id="Tag416" decimals="-5" contextRef="D2011Q1_M01_NovoNordiskASMember" unitRef="USD"> 1500000 </pcrx:CollaborativeArrangementUpfrontPaymentReceived>
<pcrx:CollaborativeArrangementMilestonePaymentsReceived id="Tag417" decimals="-5" contextRef="D2011Q4_M11_NovoNordiskASMember" unitRef="USD"> 2000000 </pcrx:CollaborativeArrangementMilestonePaymentsReceived>
<us-gaap:OffMarketLeaseUnfavorable id="Tag418" decimals="-5" contextRef="I2007Q1" unitRef="USD"> 3300000 </us-gaap:OffMarketLeaseUnfavorable>
<pcrx:AmortizationOfUnfavorableLeaseAccrual id="Tag419" decimals="-5" contextRef="D2012" unitRef="USD"> 400000 </pcrx:AmortizationOfUnfavorableLeaseAccrual>
<pcrx:AmortizationOfUnfavorableLeaseAccrual id="Tag420" decimals="-5" contextRef="D2011" unitRef="USD"> 400000 </pcrx:AmortizationOfUnfavorableLeaseAccrual>
<pcrx:AmortizationOfUnfavorableLeaseAccrual id="Tag421" decimals="-5" contextRef="D2010" unitRef="USD"> 400000 </pcrx:AmortizationOfUnfavorableLeaseAccrual>
<us-gaap:OperatingLeasesFutureMinimumPaymentsDueInTwoYears id="Tag422" decimals="-3" contextRef="I2012" unitRef="USD"> 5284000 </us-gaap:OperatingLeasesFutureMinimumPaymentsDueInTwoYears>
<us-gaap:OperatingLeasesFutureMinimumPaymentsDueInThreeYears id="Tag423" decimals="-3" contextRef="I2012" unitRef="USD"> 5463000 </us-gaap:OperatingLeasesFutureMinimumPaymentsDueInThreeYears>
<us-gaap:OperatingLeasesFutureMinimumPaymentsDueInFourYears id="Tag424" decimals="-3" contextRef="I2012" unitRef="USD"> 3464000 </us-gaap:OperatingLeasesFutureMinimumPaymentsDueInFourYears>
<us-gaap:OperatingLeasesFutureMinimumPaymentsDueThereafter id="Tag425" decimals="-3" contextRef="I2012" unitRef="USD"> 201000 </us-gaap:OperatingLeasesFutureMinimumPaymentsDueThereafter>
<us-gaap:OperatingLeasesFutureMinimumPaymentsDue id="Tag426" decimals="-3" contextRef="I2012" unitRef="USD"> 14817000 </us-gaap:OperatingLeasesFutureMinimumPaymentsDue>
<us-gaap:OperatingLeasesRentExpenseNet id="Tag427" decimals="-5" contextRef="D2012" unitRef="USD"> 4800000 </us-gaap:OperatingLeasesRentExpenseNet>
<us-gaap:OperatingLeasesFutureMinimumPaymentsDueInFiveYears id="Tag428" decimals="-3" contextRef="I2012" unitRef="USD"> 405000 </us-gaap:OperatingLeasesFutureMinimumPaymentsDueInFiveYears>
<us-gaap:OperatingLeasesRentExpenseNet id="Tag429" decimals="-5" contextRef="D2011" unitRef="USD"> 4700000 </us-gaap:OperatingLeasesRentExpenseNet>
<us-gaap:OperatingLeasesRentExpenseNet id="Tag430" decimals="-5" contextRef="D2010" unitRef="USD"> 4500000 </us-gaap:OperatingLeasesRentExpenseNet>
<us-gaap:DeferredRentCreditNoncurrent id="Tag431" decimals="-5" contextRef="I2012" unitRef="USD"> 1300000 </us-gaap:DeferredRentCreditNoncurrent>
<us-gaap:DeferredRentCreditNoncurrent id="Tag432" decimals="-5" contextRef="I2011" unitRef="USD"> 1400000 </us-gaap:DeferredRentCreditNoncurrent>
<us-gaap:BusinessAcquisitionCostOfAcquiredEntityPurchasePrice id="Tag433" decimals="-5" contextRef="I2007Q1_M0321_CaliforniaOperatingSubsidiaryMember" unitRef="USD"> 19600000 </us-gaap:BusinessAcquisitionCostOfAcquiredEntityPurchasePrice>
<pcrx:AgreedMilestonePaymentsForSaleOfProductInConnectionWithAcquisition id="Tag434" decimals="-5" contextRef="I2012_SkyePharmaHoldingIncMember" unitRef="USD"> 62000000 </pcrx:AgreedMilestonePaymentsForSaleOfProductInConnectionWithAcquisition>
<pcrx:AnnualNetSalesThresholdForDeterminingMilestonePaymentsForProductInConnectionWithAcquisition id="Tag435" decimals="-6" contextRef="I2012_MaximumMember_SalesMilestoneReachingDollars100MillionMember" unitRef="USD"> 100000000 </pcrx:AnnualNetSalesThresholdForDeterminingMilestonePaymentsForProductInConnectionWithAcquisition>
<pcrx:AnnualNetSalesThresholdForDeterminingMilestonePaymentsForProductInConnectionWithAcquisition id="Tag436" decimals="-6" contextRef="I2012_MaximumMember_SalesMilestoneReachingDollars250MillionMember" unitRef="USD"> 250000000 </pcrx:AnnualNetSalesThresholdForDeterminingMilestonePaymentsForProductInConnectionWithAcquisition>
<pcrx:AnnualNetSalesThresholdForDeterminingMilestonePaymentsForProductInConnectionWithAcquisition id="Tag437" decimals="-6" contextRef="I2012_MaximumMember_SalesMilestoneReachingDollars500MillionMember" unitRef="USD"> 500000000 </pcrx:AnnualNetSalesThresholdForDeterminingMilestonePaymentsForProductInConnectionWithAcquisition>
<pcrx:PercentageOfRoyaltyOnSaleOfProduct id="Tag438" decimals="2" contextRef="D2012" unitRef="Pure"> 0.03 </pcrx:PercentageOfRoyaltyOnSaleOfProduct>
<us-gaap:RevenueFromRelatedParties id="Tag439" decimals="-5" contextRef="D2010Q2_M04_RhythmPharmaceuticalsIncMember" unitRef="USD"> 300000 </us-gaap:RevenueFromRelatedParties>
<us-gaap:RelatedPartyTransactionPurchasesFromRelatedParty id="Tag440" decimals="-4" contextRef="D2011Q4_M11_StackPharmaceuticalsIncMember" unitRef="USD"> 20000 </us-gaap:RelatedPartyTransactionPurchasesFromRelatedParty>
<pcrx:RelatedPartyTransactionFeePayablePerYear id="Tag441" decimals="0" contextRef="I2011Q2_DirectorMember_ConsultingAgreementMember_MaximumMember" unitRef="USD"> 60000 </pcrx:RelatedPartyTransactionFeePayablePerYear>
<us-gaap:RelatedPartyTransactionAmountsOfTransaction id="Tag442" decimals="-5" contextRef="D2011_MPMAssetManagementMember" unitRef="USD"> 500000 </us-gaap:RelatedPartyTransactionAmountsOfTransaction>
<us-gaap:RelatedPartyTransactionAmountsOfTransaction id="Tag443" decimals="-5" contextRef="D2010_MPMAssetManagementMember" unitRef="USD"> 700000 </us-gaap:RelatedPartyTransactionAmountsOfTransaction>
<us-gaap:RelatedPartyTransactionAmountsOfTransaction id="Tag444" decimals="-5" contextRef="D2012_MPMAssetManagementMember" unitRef="USD"> 400000 </us-gaap:RelatedPartyTransactionAmountsOfTransaction>
<us-gaap:RelatedPartyTransactionAmountsOfTransaction id="Tag445" decimals="-5" contextRef="D2011_StackPharmaceuticalsIncMember" unitRef="USD"> 200000 </us-gaap:RelatedPartyTransactionAmountsOfTransaction>
<us-gaap:RelatedPartyTransactionAmountsOfTransaction id="Tag446" decimals="-5" contextRef="D2010_StackPharmaceuticalsIncMember" unitRef="USD"> 300000 </us-gaap:RelatedPartyTransactionAmountsOfTransaction>
<us-gaap:DueToRelatedPartiesCurrentAndNoncurrent id="Tag447" decimals="-5" contextRef="I2011_MPMAssetManagementMember" unitRef="USD"> 200000 </us-gaap:DueToRelatedPartiesCurrentAndNoncurrent>
<pcrx:RelatedPartyTransactionFeePayablePerMonth id="Tag448" decimals="0" contextRef="I2012_MPMAssetManagementMember" unitRef="USD"> 26000 </pcrx:RelatedPartyTransactionFeePayablePerMonth>
<us-gaap:ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock id="Tag449" contextRef="D2012">
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"> <p style="FONT-FAMILY: times"><font size="2">The following table summarizes the Company's stock option activity and related information for the period from January 1, 2010 to December 31, 2012 (in thousands except share and per share amounts):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 10%; WIDTH: 73%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"110%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table style="WIDTH: 839px; HEIGHT: 142px" cellspacing="0" cellpadding="0" width="839" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="55"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="75"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="78"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="69"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Number of<br /> shares</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Weighted<br /> average exercise<br /> price</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Weighted<br /> Average<br /> remaining<br /> contractual term<br /> (years)</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Aggregate<br /> intrinsic value<br /> (in thousands)</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Outstanding at January 1, 2010</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">52,430</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">1.79</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">8.06</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">47</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="white"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Granted</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">2,028,158</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">2.71</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Exercised</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(1,177</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">1.89</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">1</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="white"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Forfeited</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(3,337</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">1.89</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Expired</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(2,374</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">1.75</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom" align="right"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="white"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Outstanding at December 31, 2010</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">2,073,700</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">2.69</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">9.70</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">6</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Granted</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">395,234</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">10.21</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="white"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Exercised</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(67,456</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">2.01</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">420</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Forfeited</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(62,776</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">5.05</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="white"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Expired</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(1,685</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">2.69</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom" align="right"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Outstanding at December 31, 2011</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">2,337,017</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">3.92</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">8.80</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">11,829</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="white"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Granted</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">2,120,250</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">11.55</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Exercised</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(279,476</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">2.75</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">3,005</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="white"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Forfeited</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(174,610</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">7.94</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Expired</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">(15</font></td> <td style="FONT-FAMILY: times"><font size="2">)</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">7.07</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom" align="right"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="white"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Outstanding at December 31, 2012</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">4,003,166</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">7.86</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">8.66</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">38,485</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Exercisable at December 31, 2012</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">1,269,921</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">3.76</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">7.80</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">17,415</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="bottom" bgcolor="white"> <td style="FONT-FAMILY: times"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Vested and expected to vest at December 31, 2012</font></p></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">3,889,392</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">7.78</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">8.64</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" align="right"><font size="2">37,686</font></td> <td style="FONT-FAMILY: times"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
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<us-gaap:AllocatedShareBasedCompensationExpense id="Tag450" decimals="-3" contextRef="D2011_CostOfSalesMember" unitRef="USD"> 218000 </us-gaap:AllocatedShareBasedCompensationExpense>
<us-gaap:AllocatedShareBasedCompensationExpense id="Tag451" decimals="-3" contextRef="D2011_ResearchAndDevelopmentExpenseMember" unitRef="USD"> 804000 </us-gaap:AllocatedShareBasedCompensationExpense>
<us-gaap:AllocatedShareBasedCompensationExpense id="Tag452" decimals="-3" contextRef="D2011_SellingGeneralAndAdministrativeExpensesMember" unitRef="USD"> 1471000 </us-gaap:AllocatedShareBasedCompensationExpense>
<us-gaap:AllocatedShareBasedCompensationExpense id="Tag453" decimals="-3" contextRef="D2011" unitRef="USD"> 2493000 </us-gaap:AllocatedShareBasedCompensationExpense>
<us-gaap:AllocatedShareBasedCompensationExpense id="Tag454" decimals="-3" contextRef="D2010_CostOfSalesMember" unitRef="USD"> 12000 </us-gaap:AllocatedShareBasedCompensationExpense>
<us-gaap:AllocatedShareBasedCompensationExpense id="Tag455" decimals="-3" contextRef="D2010_ResearchAndDevelopmentExpenseMember" unitRef="USD"> 10000 </us-gaap:AllocatedShareBasedCompensationExpense>
<us-gaap:AllocatedShareBasedCompensationExpense id="Tag456" decimals="-3" contextRef="D2010_SellingGeneralAndAdministrativeExpensesMember" unitRef="USD"> 1000 </us-gaap:AllocatedShareBasedCompensationExpense>
<us-gaap:AllocatedShareBasedCompensationExpense id="Tag457" decimals="-3" contextRef="D2010" unitRef="USD"> 23000 </us-gaap:AllocatedShareBasedCompensationExpense>
<us-gaap:AllocatedShareBasedCompensationExpense id="Tag458" decimals="-3" contextRef="D2012_CostOfSalesMember" unitRef="USD"> 563000 </us-gaap:AllocatedShareBasedCompensationExpense>
<us-gaap:AllocatedShareBasedCompensationExpense id="Tag459" decimals="-3" contextRef="D2012_ResearchAndDevelopmentExpenseMember" unitRef="USD"> 1155000 </us-gaap:AllocatedShareBasedCompensationExpense>
<us-gaap:AllocatedShareBasedCompensationExpense id="Tag460" decimals="-3" contextRef="D2012_SellingGeneralAndAdministrativeExpensesMember" unitRef="USD"> 3058000 </us-gaap:AllocatedShareBasedCompensationExpense>
<us-gaap:AllocatedShareBasedCompensationExpense id="Tag461" decimals="-3" contextRef="D2012" unitRef="USD"> 4776000 </us-gaap:AllocatedShareBasedCompensationExpense>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized id="Tag462" decimals="INF" contextRef="I2012_Plan2007Member" unitRef="Shares"> 2066018 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized id="Tag463" decimals="INF" contextRef="D2012Q1_M01_StockIncentivePlan2011Member" unitRef="Shares"> 557880 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized id="Tag464" decimals="INF" contextRef="I2012_StockIncentivePlan2011Member" unitRef="Shares"> 3138519 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized id="Tag465" decimals="INF" contextRef="I2012" unitRef="Shares"> 5204537 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod id="Tag466" decimals="INF" contextRef="D2012_StockIncentivePlan2011Member" unitRef="Shares"> 2393214 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod id="Tag467" decimals="INF" contextRef="D2012_Plan2007Member" unitRef="Shares"> 2066018 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod id="Tag468" decimals="INF" contextRef="D2012" unitRef="Shares"> 4459232 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant id="Tag469" decimals="INF" contextRef="I2012_StockIncentivePlan2011Member" unitRef="Shares"> 745305 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant id="Tag470" decimals="INF" contextRef="I2012" unitRef="Shares"> 745305 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum id="Tag471" decimals="3" contextRef="D2011_StockOptionsMember_S" unitRef="Pure"> 0.011 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum id="Tag472" decimals="3" contextRef="D2011_StockOptionsMember_S" unitRef="Pure"> 0.027 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate id="Tag473" decimals="3" contextRef="D2011_StockOptionsMember_S" unitRef="Pure"> 0.768 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate>
<us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1 id="Tag474" contextRef="D2011_StockOptionsMember_S"> P6Y8M23D </us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1>
<us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1 id="Tag475" contextRef="D2010_StockOptionsMember_S"> P6Y3M </us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1>
<us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1 id="Tag476" contextRef="D2012_StockOptionsMember_S"> P6Y9M4D </us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate id="Tag477" decimals="3" contextRef="D2010_StockOptionsMember_S" unitRef="Pure"> 0.808 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate id="Tag478" decimals="3" contextRef="D2012_StockOptionsMember_S" unitRef="Pure"> 0.740 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum id="Tag479" decimals="3" contextRef="D2010_StockOptionsMember_S" unitRef="Pure"> 0.034 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum id="Tag480" decimals="4" contextRef="D2012_StockOptionsMember_S" unitRef="Pure"> 0.0170 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum id="Tag481" decimals="3" contextRef="D2010_StockOptionsMember_S" unitRef="Pure"> 0.016 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum id="Tag482" decimals="4" contextRef="D2012_StockOptionsMember_S" unitRef="Pure"> 0.0084 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue id="Tag483" decimals="2" contextRef="D2011_StockOptionsMember_S" unitRef="USDPerShare"> 7.06 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue id="Tag484" decimals="2" contextRef="D2010_StockOptionsMember_S" unitRef="USDPerShare"> 5.61 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue id="Tag485" decimals="2" contextRef="D2012_StockOptionsMember_S" unitRef="USDPerShare"> 8.52 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue>
<us-gaap:EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1 id="Tag486" contextRef="D2012_StockOptionsMember_S"> P3Y </us-gaap:EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1>
<us-gaap:EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions id="Tag487" decimals="-5" contextRef="I2012_StockOptionsMember" unitRef="USD"> 17700000 </us-gaap:EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber id="Tag488" decimals="INF" contextRef="I2010_StockOptionsMember" unitRef="Shares"> 2073700 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber id="Tag489" decimals="INF" contextRef="I2011_StockOptionsMember" unitRef="Shares"> 2337017 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross id="Tag490" decimals="INF" contextRef="D2011_StockOptionsMember_S" unitRef="Shares"> 395234 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross>
<us-gaap:StockIssuedDuringPeriodSharesStockOptionsExercised id="Tag491" decimals="INF" contextRef="D2011_StockOptionsMember_S" unitRef="Shares"> 67456 </us-gaap:StockIssuedDuringPeriodSharesStockOptionsExercised>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod id="Tag492" decimals="INF" contextRef="D2011_StockOptionsMember_S" unitRef="Shares"> 62776 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod id="Tag493" decimals="INF" contextRef="D2011_StockOptionsMember_S" unitRef="Shares"> 1685 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice id="Tag494" decimals="2" contextRef="I2010_StockOptionsMember" unitRef="USDPerShare"> 2.69 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice id="Tag495" decimals="2" contextRef="I2011_StockOptionsMember" unitRef="USDPerShare"> 3.92 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice>
<us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice id="Tag496" decimals="2" contextRef="D2011_StockOptionsMember_S" unitRef="USDPerShare"> 10.21 </us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice>
<us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice id="Tag497" decimals="2" contextRef="D2011_StockOptionsMember_S" unitRef="USDPerShare"> 2.01 </us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice>
<us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice id="Tag498" decimals="2" contextRef="D2011_StockOptionsMember_S" unitRef="USDPerShare"> 5.05 </us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice>
<us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice id="Tag499" decimals="2" contextRef="D2011_StockOptionsMember_S" unitRef="USDPerShare"> 2.69 </us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice>
<us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2 id="Tag500" contextRef="D2010_StockOptionsMember_S"> P9Y8M12D </us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue id="Tag501" decimals="-3" contextRef="I2010_StockOptionsMember" unitRef="USD"> 6000 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue id="Tag502" decimals="-3" contextRef="I2011_StockOptionsMember" unitRef="USD"> 11829000 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue id="Tag503" decimals="-3" contextRef="D2011_StockOptionsMember_S" unitRef="USD"> 420000 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue>
<pcrx:ScheduleOfConvertiblePreferredStockAndDebtConvertedIntoSharesOfCommonStockTableTextBlock id="Tag504" contextRef="D2012">
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"> </p> <div align="center"> <table style="WIDTH: 675px; HEIGHT: 22px" cellspacing="0" cellpadding="0" width="675" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="87"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Conversion Shares</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Series A Convertible Preferred Stock</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">6,322,640</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2009 Convertible Notes</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">871,635</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2009 Secured Notes</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">927,881</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2010 Secured Notes</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,156,606</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">HBM Secured Notes</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">297,359</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">2010 Convertible Notes</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,071,428</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
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<us-gaap:UseOfEstimates id="Tag552" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b><i>Use of Estimates</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        The preparation of financial statements in conformity with GAAP requires the use of estimates and assumptions that affect the reported amounts of assets and liabilities, including disclosure of contingent assets and contingent liabilities, at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Estimates are used for, among other things, the valuation of assets acquired, impairment of long-lived assets, goodwill, stock-based compensation and valuation of deferred tax assets. The Company's critical accounting policies are those that are both most important to the Company's consolidated financial condition and results of operations and require the most difficult, subjective or complex judgments on the part of management in their application, often as a result of the need to make estimates about the effect of matters that are inherently uncertain. Because of the uncertainty of factors surrounding the estimates or judgments used in the preparation of the consolidated financial statements, actual results could differ from these estimates.</font></p></div>
</us-gaap:UseOfEstimates>
<us-gaap:LiquidityDisclosureTextBlock id="Tag553" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b><i>Liquidity</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        Management believes that the Company's existing cash and cash equivalents, short-term investments, including the proceeds from its private offering of $120.0 million in convertible senior notes completed in January 2013, and revenue from product sales will be sufficient to enable the Company to meet its planned operating expenses, capital expenditure requirements and service its indebtedness at least through December 31, 2013. However, changing circumstances may cause the Company to expend cash significantly faster than currently anticipated, and the Company may need to spend more cash than currently expected because of circumstances beyond its control. The Company expects to continue to incur substantial additional operating losses as it commercializes EXPAREL and develops and seeks regulatory approval for its product candidates.</font></p></div>
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<us-gaap:CashAndCashEquivalentsPolicyTextBlock id="Tag554" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b><i>Cash and Cash Equivalents</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        All highly-liquid investments with maturities of 90 days or less when purchased are considered cash equivalents.</font></p></div>
</us-gaap:CashAndCashEquivalentsPolicyTextBlock>
<us-gaap:CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy id="Tag555" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b><i>Restricted Cash</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        As further discussed in Note 9,</font> <font size="2"><i>Debt</i></font><font size="2">, the Company has entered into a financing agreement with Royalty Securitization Trust I ("RST") for the sale of a royalty interest in its DepoCyt(e) and DepoDur product revenue and royalties. As part of this financing agreement, the Company and RST maintain a lockbox, where all DepoCyt(e) and DepoDur product revenue and royalties are received. The Company has no minimum payment obligations under this agreement. Commencing on April 1 of every year, the first $2.5 million received in the lockbox is restricted and is used to make quarterly payments due to RST, if any, under the agreement during the subsequent 12 month period. On March 31 of the subsequent year, the balance of cash in the lockbox, if any, is remitted to the Company. The RST agreement terminates on December 31, 2014. The royalty interest agreement pertains only to DepoCyt(e) and DepoDur, and does not include revenue related to EXPAREL or any other product candidates.</font></p></div>
</us-gaap:CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy>
<us-gaap:MarketableSecuritiesPolicy id="Tag556" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b><i>Short-Term Investments</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company determines the appropriate classification of its investments at the time of purchase and reevaluates such determination at each balance sheet date. The Company's investment policy sets minimum credit quality criteria and maximum maturity limits on its investments to provide for preservation of capital, liquidity and a reasonable rate of return. Available-for-sale securities are recorded at fair value, based on current market valuations. Unrealized holding gains and losses on available-for-sale securities are excluded from net loss and are reported as a separate component of other comprehensive income (loss) until realized. Realized gains and losses are included in non-operating other income (expense) on the consolidated statement of operations and are derived using the specific identification method for determining the cost of the securities sold.</font></p></div>
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<us-gaap:MajorCustomersPolicyPolicyTextBlock id="Tag557" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b><i>Concentration of Major Customers</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company's customers are its major and regional wholesalers and commercial and collaborative and licensing partners. The Company is dependent on its commercial partners to market and sell DepoCyt(e). The table below includes the percentage of revenue comprised by the three largest customers in each year presented.</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="100%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="64"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="64"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="64"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="8"><font size="1"><b>Year Ended</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br /> 2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br /> 2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br /> 2010</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Largest customer</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">30</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">43</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">49</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Second largest customer</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">14</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">23</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">21</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Third largest customer</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">11</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">19</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">13</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"> </p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">55</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">85</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">83</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div> <p style="FONT-FAMILY: times"><font size="2">        Sales to customers outside the U.S. accounted for 23%, 64% and 52% of the Company's revenue for the years ended December 31, 2012, 2011 and 2010, respectively.</font></p></div>
</us-gaap:MajorCustomersPolicyPolicyTextBlock>
<us-gaap:InventoryPolicyTextBlock id="Tag558" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b><i>Inventories</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        Inventories consist of finished goods held for sale and distribution, raw materials and work in process, and are stated at the lower of cost, which includes amounts related to material, labor and overhead, or market (net realizable) value and is determined using the first-in, first-out ("FIFO") method. The Company periodically reviews its inventory to identify obsolete, slow-moving or otherwise unsalable inventories, and establishes allowances for situations in which the cost of the inventory is not expected to be recovered. Overhead costs associated with excess manufacturing capacity are charged to cost of revenue, as incurred.</font></p></div>
</us-gaap:InventoryPolicyTextBlock>
<us-gaap:PropertyPlantAndEquipmentPolicyTextBlock id="Tag559" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b><i>Fixed Assets</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        Fixed assets are recorded at cost, net of accumulated depreciation and amortization. The Company reviews its property, plant and equipment assets for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset may not be recoverable.</font></p> <p style="FONT-FAMILY: times"><font size="2">        Depreciation of fixed assets is provided over their estimated useful lives on a straight-line basis. Leasehold improvements are amortized on a straight-line basis over the shorter of their estimated useful lives or the related lease terms. Useful lives by asset category are as follows:</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table cellspacing="0" cellpadding="0" width="100%" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="left" width="75"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" nowrap="nowrap" align="left"> <div style="MARGIN-BOTTOM: 0pt; WIDTH: 53pt; BORDER-BOTTOM: #000000 1pt solid"><font size="1"><b>Asset Category <!-- COMMAND=ADD_SCROPPEDRULE,53pt --></b></font></div></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center"><font size="1"><b>Years</b></font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Manufacturing and laboratory equipment</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">5 to 10 years</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Computer equipment and software</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">1 to 3 years</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Office furniture and equipment</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">5 years</font></td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
</us-gaap:PropertyPlantAndEquipmentPolicyTextBlock>
<us-gaap:ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock id="Tag560" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b><i>Impairment of Long-Lived Assets</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        Management reviews long-lived assets, including fixed assets, for impairment whenever events or changes in circumstances indicate the carrying amount of an asset may not be recoverable. Recoverability of assets to be held and used is measured by a comparison of the carrying amount of an asset to future undiscounted net cash flows expected to be generated by the asset. If such assets are considered to be impaired, the impairment to be recognized is measured as the amount by which the carrying amount of the assets exceeds the fair value of the assets.</font></p></div>
</us-gaap:ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock>
<us-gaap:ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock id="Tag561" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b><i>Foreign Currencies</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company receives payment from certain of its commercial partners relating to royalties on DepoCyte in Euros. Realized gains and losses from foreign currency transactions are reflected in the consolidated statements of operations and were not significant in any period. All foreign currency receivables and payables are measured at the applicable exchange rate at the end of the reporting period.</font></p></div>
</us-gaap:ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock>
<us-gaap:IncomeTaxPolicyTextBlock id="Tag562" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b><i>Income Taxes</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company uses the asset and liability method of accounting for income taxes. Deferred tax assets and liabilities are recognized for the estimated future tax consequences attributable to differences between the financial statement carrying amounts of existing assets and liabilities and their respective tax bases. Deferred tax assets and liabilities are measured using enacted tax rates expected to apply to taxable income in the years in which those temporary differences are expected to be recovered or settled. Valuation allowances are established when necessary to reduce deferred tax assets to the amount expected to be realized. As of December 31, 2012 and 2011, all deferred tax assets were fully offset by a valuation allowance.</font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company accrues interest and penalties, if any, on underpayment of income taxes related to unrecognized tax benefits as a component of income tax expense in its consolidated statements of operations.</font></p></div>
</us-gaap:IncomeTaxPolicyTextBlock>
<us-gaap:RevenueRecognitionPolicyTextBlock id="Tag563" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b><i>Revenue Recognition</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Product Sales</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company sells EXPAREL primarily to wholesalers based on orders of the product from hospitals and other end user customers such as ambulatory surgery centers and doctors. The Company recognizes revenue when there is persuasive evidence that an arrangement exists, title has passed, collection is reasonably assured and the price is fixed or determinable. Sales to wholesalers provide for selling prices that are fixed on the date of sale. EXPAREL is delivered directly to the end user with the wholesaler never taking physical possession of the product. The Company records revenue at the time the product is delivered to the end user. The Company also recognizes revenue from products manufactured and supplied to commercial partners. Prior to the shipment of the manufactured products such as DepoCyt(e), the Company conducts initial product release and stability testing in accordance with current Good Manufacturing Practices, or cGMP.</font></p> <p style="FONT-FAMILY: times"><font size="2">        At the time the Company recognizes revenue, it also records certain sales reserves and allowances as a reduction of revenue. These reserves and allowances include a prompt payment reserve, return reserves, volume rebates, chargeback reserve and wholesaler service fee. Due to estimates and assumptions inherent in determining some of the sales reserves, the actual amount of volume rebates, chargebacks and returns may be different from estimates, at which time the Company would adjust the reserves accordingly.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Prompt Pay Reserve</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        The prompt payment reserve is based upon discounts offered to wholesalers as an incentive to meet certain payment terms. The Company accounts for these discounts at the time the sale is made and reduces accounts receivable accordingly.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Return Reserves</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company allows customers to return product that is damaged or received in error. In addition, the Company allows for EXPAREL product to be returned beginning six months prior to, and twelve months following product expiration. As EXPAREL is a new commercially available product, the Company is estimating its sales return reserve based on return history from other hospital-based products with similar distribution models, which management believes is the best estimate of the anticipated product to be returned. The returns reserve is recorded at the time of sale as a reduction to sales and an increase in returns liability.</font></p> <p style="FONT-FAMILY: times"><font size="2">        Commercial partners can return the products within contracted specified timeframes if the products do not meet the applicable inspection tests. Historically, returns from commercial partners have not been material.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Volume Rebates and Chargeback Reserve</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        Volume rebates and chargeback reserve are based upon contracted discounts and promotional offers the Company provides to certain end users, including hospitals and ambulatory surgery centers such as members of group purchasing organizations. The volume rebates and chargeback reserve are recorded as a reduction to sales and a customer payable and reduction to receivables, respectively.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Wholesaler Service Fee</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company's customers include major and regional wholesalers with whom the Company has contracted a fee for service based on a percentage of sales. This fee for service is recorded as a reduction to gross sales and a liability is established at the time the sale is recorded based on the contracted percentage.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Allowance for Doubtful Accounts</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company evaluates its accounts receivable to determine if a provision for an allowance for doubtful accounts is appropriate. The Company's sales to date are primarily to established customers. As of December 31, 2012 and 2011, the accounts receivable was considered collectible and no allowance for doubtful accounts was recorded.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Royalty Revenue</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company recognizes revenue from royalties based on sales of its products by commercial partners. Royalties are recognized as earned in accordance with contract terms when they can be estimated based on historical product sales, royalty receipts and other relevant information and collectability is reasonably assured.</font></p> <p style="FONT-FAMILY: times"><font size="2"><i>Collaborative Licensing and Development Revenue</i></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company recognizes revenue from reimbursements received in connection with feasibility studies and development work for third parties who desire to utilize its DepoFoam extended release drug delivery technology for their products when the Company's contractual services are performed, provided collectability is reasonably assured. The Company's principal costs under these agreements include its personnel conducting research and development and allocated overhead, as well as research and development performed by outside contractors or consultants.</font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company recognizes revenues from non-refundable up-front license fees received ratably over the performance period using the estimated development period in development agreements and the contract period or longest patent life in supply and distribution agreements. If the estimated performance period is subsequently modified, the Company will modify the period over which the up-front license fee is recognized accordingly on a prospective basis. Upon notification of a termination of a collaboration agreement, any remaining non-refundable license fees received by the Company, which had been deferred, are recognized over the remaining contractual term. If the termination is immediate and no additional services are to be performed, the deferred revenue is generally recognized in full. All such recognized revenues are included in collaborative licensing and development revenue in the Company's consolidated statements of operations.</font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company recognizes revenue from milestone payments received under collaboration agreements when earned, provided that the milestone event is substantive, its achievability was not reasonably assured at the inception of the agreement, the Company has no further performance obligations relating to the event, and collectability is reasonably assured. If these criteria are not met, the Company recognizes milestone payments ratably over the remaining period of the Company's performance obligations under the collaboration agreement. All such recognized revenues are included in collaborative licensing and development revenue in the Company's consolidated statements of operations.</font></p></div>
</us-gaap:RevenueRecognitionPolicyTextBlock>
<us-gaap:ResearchAndDevelopmentExpensePolicy id="Tag564" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b><i>Research and Development Expenses</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        Research and development expenses consist of costs associated with products being developed internally, and include related personnel expenses, laboratory supplies, active pharmaceutical ingredients, manufacturing supplies, facilities costs, preclinical and clinical trial costs, and other outside service fees. The Company expenses research and development costs as incurred. A significant portion of the Company's development activities are outsourced to third parties, including contract research organizations. In such cases, the Company may be required to estimate related service fees to be accrued.</font></p></div>
</us-gaap:ResearchAndDevelopmentExpensePolicy>
<us-gaap:EarningsPerSharePolicyTextBlock id="Tag565" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b><i>Per Share Data</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        Basic net loss per share is computed by dividing net loss available (attributable) to common stockholders by the weighted average number of shares of common stock outstanding during the period. Because the holders of the Series A convertible preferred stock were not contractually required to share in the Company's losses, in applying the two-class method to compute basic net loss per common share no allocation to preferred stock was made for the years ended December 31, 2011 and 2010. At December 31, 2012, there were no Series A convertible preferred stock outstanding as a result of the initial public offering on February 8, 2011 when all convertible preferred stock was converted into common stock.</font></p> <p style="FONT-FAMILY: times"><font size="2">        Diluted net income (loss) per share is calculated by dividing net income available (attributable) to common stockholders as adjusted for the effect of dilutive securities, if any, by the weighted average number of common stock and dilutive common stock outstanding during the period. Potential common shares include the shares of common stock issuable upon the exercise of outstanding stock options and warrants (using the treasury stock method). Potential common shares in the diluted net loss per share computation are excluded to the extent that they would be anti-dilutive. No potentially dilutive securities are included in the computation of any diluted per share amounts as the Company reported a net loss for all periods presented.</font></p></div>
</us-gaap:EarningsPerSharePolicyTextBlock>
<us-gaap:ShareBasedCompensationOptionAndIncentivePlansPolicy id="Tag566" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b><i>Stock-Based Compensation</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company's stock-based compensation programs include grants of stock options to employees, consultants and non-employee directors. The expense associated with these programs is recognized in the Company's consolidated statements of operations based on their fair values as they are earned under the applicable vesting terms.</font></p> <p style="FONT-FAMILY: times"><font size="2">        The valuation of stock options is an inherently subjective process, since market values are generally not available for long-term, non-transferable stock options. Accordingly, the Company uses an option pricing model to derive an estimated fair value. In calculating the estimated fair value of stock options granted, the Company uses the Black-Scholes option pricing model which requires the consideration of the following variables for purposes of estimating fair value:</font></p> <ul> <li style="list-style: none"> <dl compact="compact"> <dt style="MARGIN-BOTTOM: -11pt; FONT-FAMILY: times"><font size="2"></font></dt> <dd style="FONT-FAMILY: times"><font size="2">Expected term of the option</font> <font size="2"><br /> <br /></font></dd> <dt style="MARGIN-BOTTOM: -11pt; FONT-FAMILY: times"><font size="2"></font></dt> <dd style="FONT-FAMILY: times"><font size="2">Expected volatility</font> <font size="2"><br /> <br /></font></dd> <dt style="MARGIN-BOTTOM: -11pt; FONT-FAMILY: times"><font size="2"></font></dt> <dd style="FONT-FAMILY: times"><font size="2">Expected dividends</font> <font size="2"><br /> <br /></font></dd> <dt style="MARGIN-BOTTOM: -11pt; FONT-FAMILY: times"><font size="2"></font></dt> <dd style="FONT-FAMILY: times"><font size="2">Risk-free interest rate</font><br /> <br /> <br /> <p style="FONT-FAMILY: times"><font size="2">        Because the Company's common stock was not publicly held prior to February 2011, the expected volatility was based on the historic volatility for publicly traded industry peers for shares granted prior to the initial public offering. Since its initial public offering, the Company utilizes its available historic volatility data combined with the publicly traded peer's historic volatility to determine expected volatility over the expected option term. The Company's limited historical stock option exercise experience does not provide a reasonable basis upon which to estimate expected term. Accordingly, the Company uses a term based on a simplified method, pursuant to SEC Staff Accounting Bulletin No. 107, Share-based Payment, for "plain vanilla" options. The risk-free interest rate is based on the implied yield on U.S. Department of the Treasury zero coupon bonds for periods commensurate with the expected term of the options. The dividend yield on the Company's common stock is estimated to be zero as the Company has not paid any dividends since inception. The Company estimates the level of award forfeitures expected to occur, and records compensation cost only for those awards that are ultimately expected to vest.</font></p></dd></dl></li></ul></div>
</us-gaap:ShareBasedCompensationOptionAndIncentivePlansPolicy>
<us-gaap:SegmentReportingPolicyPolicyTextBlock id="Tag567" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b><i>Segment Reporting</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        The Company operates in one reportable segment and, accordingly, no segment disclosures have been presented.</font></p></div>
</us-gaap:SegmentReportingPolicyPolicyTextBlock>
<pcrx:BasisOfPresentationAndPrinciplesOfConsolidationPolicyTextBlock id="Tag568" contextRef="D2012">
<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b><i>Basis of Presentation and Principles of Consolidation</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        The consolidated financial statements have been prepared in accordance with generally accepted accounting principles in the United States of America, or GAAP, and in accordance with the rules and regulations of the Securities and Exchange Commission, or SEC. The accounts of wholly owned subsidiaries are included in the consolidated financial statements. All intercompany balances and transactions have been eliminated in consolidation. Certain reclassifications were made to conform to the current presentation. Specifically, the Company reclassified DepoCyt(e) and DepoDur supply sales for the years ended December 31, 2011 and 2010 to net product sales to conform to the current presentation. This reclassification had no impact on net loss or stockholders' equity as previously reported.</font></p></div>
</pcrx:BasisOfPresentationAndPrinciplesOfConsolidationPolicyTextBlock>
<pcrx:AmountReceivedInLockboxRestrictedForPaymentOfRoyaltyInterest id="Tag569" decimals="-5" contextRef="D2012" unitRef="USD"> 2500000 </pcrx:AmountReceivedInLockboxRestrictedForPaymentOfRoyaltyInterest>
<pcrx:PaymentPeriodOfRoyaltyInterestFromRestrictedAmountInLockbox id="Tag570" contextRef="D2012"> P12M </pcrx:PaymentPeriodOfRoyaltyInterestFromRestrictedAmountInLockbox>
<us-gaap:ConcentrationRiskPercentage1 id="Tag571" decimals="2" contextRef="D2012_SalesRevenueGoodsNetMember_CustomerConcentrationRiskMember_LargestCustomerMember" unitRef="Pure"> 0.30 </us-gaap:ConcentrationRiskPercentage1>
<us-gaap:ConcentrationRiskPercentage1 id="Tag572" decimals="2" contextRef="D2012_SalesRevenueGoodsNetMember_CustomerConcentrationRiskMember_SecondLargestCustomerMember" unitRef="Pure"> 0.14 </us-gaap:ConcentrationRiskPercentage1>
<us-gaap:ConcentrationRiskPercentage1 id="Tag573" decimals="2" contextRef="D2012_SalesRevenueGoodsNetMember_CustomerConcentrationRiskMember_ThirdLargestCustomerMember" unitRef="Pure"> 0.11 </us-gaap:ConcentrationRiskPercentage1>
<us-gaap:ConcentrationRiskPercentage1 id="Tag574" decimals="2" contextRef="D2012_SalesRevenueGoodsNetMember_CustomerConcentrationRiskMember" unitRef="Pure"> 0.55 </us-gaap:ConcentrationRiskPercentage1>
<us-gaap:ConcentrationRiskPercentage1 id="Tag575" decimals="2" contextRef="D2011_SalesRevenueGoodsNetMember_CustomerConcentrationRiskMember_LargestCustomerMember" unitRef="Pure"> 0.43 </us-gaap:ConcentrationRiskPercentage1>
<us-gaap:ConcentrationRiskPercentage1 id="Tag576" decimals="2" contextRef="D2011_SalesRevenueGoodsNetMember_CustomerConcentrationRiskMember_SecondLargestCustomerMember" unitRef="Pure"> 0.23 </us-gaap:ConcentrationRiskPercentage1>
<us-gaap:ConcentrationRiskPercentage1 id="Tag577" decimals="2" contextRef="D2011_SalesRevenueGoodsNetMember_CustomerConcentrationRiskMember_ThirdLargestCustomerMember" unitRef="Pure"> 0.19 </us-gaap:ConcentrationRiskPercentage1>
<us-gaap:ConcentrationRiskPercentage1 id="Tag578" decimals="2" contextRef="D2011_SalesRevenueGoodsNetMember_CustomerConcentrationRiskMember" unitRef="Pure"> 0.85 </us-gaap:ConcentrationRiskPercentage1>
<us-gaap:ConcentrationRiskPercentage1 id="Tag579" decimals="2" contextRef="D2010_SalesRevenueGoodsNetMember_CustomerConcentrationRiskMember_LargestCustomerMember" unitRef="Pure"> 0.49 </us-gaap:ConcentrationRiskPercentage1>
<us-gaap:ConcentrationRiskPercentage1 id="Tag580" decimals="2" contextRef="D2010_SalesRevenueGoodsNetMember_CustomerConcentrationRiskMember_SecondLargestCustomerMember" unitRef="Pure"> 0.21 </us-gaap:ConcentrationRiskPercentage1>
<us-gaap:ConcentrationRiskPercentage1 id="Tag581" decimals="2" contextRef="D2010_SalesRevenueGoodsNetMember_CustomerConcentrationRiskMember_ThirdLargestCustomerMember" unitRef="Pure"> 0.13 </us-gaap:ConcentrationRiskPercentage1>
<us-gaap:ConcentrationRiskPercentage1 id="Tag582" decimals="2" contextRef="D2010_SalesRevenueGoodsNetMember_CustomerConcentrationRiskMember" unitRef="Pure"> 0.83 </us-gaap:ConcentrationRiskPercentage1>
<us-gaap:ConcentrationRiskPercentage1 id="Tag583" decimals="2" contextRef="D2011_SalesRevenueGoodsNetMember_CustomerConcentrationRiskMember_CustomersOutsideUSMember" unitRef="Pure"> 0.64 </us-gaap:ConcentrationRiskPercentage1>
<us-gaap:ConcentrationRiskPercentage1 id="Tag584" decimals="2" contextRef="D2010_SalesRevenueGoodsNetMember_CustomerConcentrationRiskMember_CustomersOutsideUSMember" unitRef="Pure"> 0.52 </us-gaap:ConcentrationRiskPercentage1>
<us-gaap:PropertyPlantAndEquipmentUsefulLife id="Tag585" contextRef="D2012_MachineryAndEquipmentMember_MinimumMember"> P5Y </us-gaap:PropertyPlantAndEquipmentUsefulLife>
<us-gaap:PropertyPlantAndEquipmentUsefulLife id="Tag586" contextRef="D2012_MachineryAndEquipmentMember_MaximumMember"> P10Y </us-gaap:PropertyPlantAndEquipmentUsefulLife>
<us-gaap:PropertyPlantAndEquipmentUsefulLife id="Tag587" contextRef="D2012_ComputerEquipmentAndSoftwareMember_MinimumMember"> P1Y </us-gaap:PropertyPlantAndEquipmentUsefulLife>
<us-gaap:PropertyPlantAndEquipmentUsefulLife id="Tag588" contextRef="D2012_ComputerEquipmentAndSoftwareMember_MaximumMember"> P3Y </us-gaap:PropertyPlantAndEquipmentUsefulLife>
<us-gaap:PropertyPlantAndEquipmentUsefulLife id="Tag589" contextRef="D2012_FurnitureAndFixturesMember"> P5Y </us-gaap:PropertyPlantAndEquipmentUsefulLife>
<us-gaap:SchedulesOfConcentrationOfRiskByRiskFactorTextBlock id="Tag590" contextRef="D2012">
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 91.88%; PADDING-TOP: 0pt; POSITION: relative; HEIGHT: 43px"> <p style="FONT-FAMILY: times"> </p> <div align="center"> <table style="WIDTH: 672px; HEIGHT: 156px" cellspacing="0" cellpadding="0" width="672" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="64"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="64"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="64"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="8"><font size="1"><b>Year Ended</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br /> 2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br /> 2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>December 31,<br /> 2010</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Largest customer</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">30</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">43</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">49</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Second largest customer</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">14</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">23</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">21</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Third largest customer</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">11</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">19</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">13</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"> </p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">55</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">85</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">83</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">%</font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
</us-gaap:SchedulesOfConcentrationOfRiskByRiskFactorTextBlock>
<us-gaap:PropertyPlantAndEquipmentTextBlock id="Tag591" contextRef="D2012">
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"> </p> <div align="center"> <table style="WIDTH: 646px; HEIGHT: 96px" cellspacing="0" cellpadding="0" width="646" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="left" width="75"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" nowrap="nowrap" align="left"> <div style="MARGIN-BOTTOM: 0pt; WIDTH: 53pt; BORDER-BOTTOM: #000000 1pt solid"><font size="1"><b>Asset Category <!-- COMMAND=ADD_SCROPPEDRULE,53pt --></b></font></div></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center"><font size="1"><b>Years</b></font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Manufacturing and laboratory equipment</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">5 to 10 years</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Computer equipment and software</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">1 to 3 years</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Office furniture and equipment</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">5 years</font></td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
</us-gaap:PropertyPlantAndEquipmentTextBlock>
<us-gaap:ScheduleOfDebtTableTextBlock id="Tag592" contextRef="D2012">
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"> <p style="FONT-FAMILY: times"><font size="2">The composition of the Company's debt and financing obligations is as follows (in thousands):</font></p> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"><font size="2"><!-- COMMAND=ADD_TABLEWIDTH,"100%" --></font></p> <!-- User-specified TAGGED TABLE --> <div align="center"> <table style="WIDTH: 757px; HEIGHT: 111px" cellspacing="0" cellpadding="0" width="757" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="45"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="5"><font size="1"><b>December 31,</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Debt:</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Current portion of long-term debt</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2"></font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">7,039</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Long-term debt</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">27,500</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">19,211</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Discount on debt</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(2,309</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">(674</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2">)</font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 30pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total debt, net of discount</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">25,191</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">25,576</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Royalty interest obligation:</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Current portion of royalty interest obligation</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">823</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,219</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 20pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Long-term portion of royalty interest obligation</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">857</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,537</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 30pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total royalty interest obligation</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">1,680</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">2,756</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 30pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Total debt and financing obligations</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">26,871</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$</font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">28,332</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
</us-gaap:ScheduleOfDebtTableTextBlock>
<pcrx:AmountToBeRaisedOnSaleOfRoyaltyInterest id="Tag593" decimals="-5" contextRef="D2000_AffiliateOfPaulCapitalAdvisorsLLCMember" unitRef="USD"> 30000000 </pcrx:AmountToBeRaisedOnSaleOfRoyaltyInterest>
<us-gaap:LineOfCreditFacilityMaximumBorrowingCapacity id="Tag594" decimals="-5" contextRef="I2010Q4_M1124_HerculesNoteMember" unitRef="USD"> 26300000 </us-gaap:LineOfCreditFacilityMaximumBorrowingCapacity>
<pcrx:DebtInstrumentSpecifiedPercentageOfReferenceRateExcessOfWhichIsAddedToFloatingRate id="Tag595" decimals="INF" contextRef="D2011Q4_M11_TrancheAOfTermLoanMember" unitRef="Pure"> 0.0400 </pcrx:DebtInstrumentSpecifiedPercentageOfReferenceRateExcessOfWhichIsAddedToFloatingRate>
<pcrx:RoyaltyInterestObligationCurrent id="Tag596" decimals="-3" contextRef="I2012" unitRef="USD"> 823000 </pcrx:RoyaltyInterestObligationCurrent>
<pcrx:RoyaltyInterestObligationNoncurrent id="Tag597" decimals="-3" contextRef="I2012" unitRef="USD"> 857000 </pcrx:RoyaltyInterestObligationNoncurrent>
<pcrx:NumberOfProductSalesOnWhichThereIsRightToReceiveRoyaltyInterest id="Tag598" decimals="INF" contextRef="D2000_AffiliateOfPaulCapitalAdvisorsLLCMember" unitRef="Item"> 4 </pcrx:NumberOfProductSalesOnWhichThereIsRightToReceiveRoyaltyInterest>
<us-gaap:DebtInstrumentIncreaseAdditionalBorrowings id="Tag599" decimals="-5" contextRef="D2010Q4_M1124_HerculesTermLoanMember" unitRef="USD"> 26300000 </us-gaap:DebtInstrumentIncreaseAdditionalBorrowings>
<pcrx:LongTermDebtIncludingRoyaltyInterestObligation id="Tag600" decimals="-3" contextRef="I2011" unitRef="USD"> 28332000 </pcrx:LongTermDebtIncludingRoyaltyInterestObligation>
<pcrx:LongTermDebtIncludingRoyaltyInterestObligation id="Tag601" decimals="-3" contextRef="I2012" unitRef="USD"> 26871000 </pcrx:LongTermDebtIncludingRoyaltyInterestObligation>
<pcrx:DebtInstrumentNumberOfTranches id="Tag602" decimals="INF" contextRef="D2010Q4_M11_HerculesTermLoanMember" unitRef="Item"> 2 </pcrx:DebtInstrumentNumberOfTranches>
<pcrx:DebtInstrumentVariableRateBaseRate id="Tag603" decimals="4" contextRef="I2010Q4_M1124_TrancheAOfTermLoanMember" unitRef="Pure"> 0.1025 </pcrx:DebtInstrumentVariableRateBaseRate>
<pcrx:DebtInstrumentVariableRateBaseRate id="Tag604" decimals="4" contextRef="I2011Q4_M1130_TrancheAOfTermLoanMember" unitRef="Pure"> 0.1100 </pcrx:DebtInstrumentVariableRateBaseRate>
<pcrx:NetPresentValueOfRoyaltiesExpectedToBeRepaid id="Tag605" decimals="-5" contextRef="I2000_AffiliateOfPaulCapitalAdvisorsLLCMember" unitRef="USD"> 13000000 </pcrx:NetPresentValueOfRoyaltiesExpectedToBeRepaid>
<us-gaap:DebtInstrumentIncreaseAdditionalBorrowings id="Tag606" decimals="-5" contextRef="D2010Q4_M11_TrancheBOfTermLoanMember" unitRef="USD"> 15000000 </us-gaap:DebtInstrumentIncreaseAdditionalBorrowings>
<pcrx:DebtInstrumentVariableRateBaseRate id="Tag607" decimals="4" contextRef="I2010Q4_M1124_TrancheBOfTermLoanMember" unitRef="Pure"> 0.1265 </pcrx:DebtInstrumentVariableRateBaseRate>
<pcrx:PurchaseOptionEventPeriodWithinWhichRightIsExercisableWhichRequiresEntityToRepurchaseRoyaltyInterestAssignment id="Tag608" contextRef="D2012_AffiliateOfPaulCapitalAdvisorsLLCMember"> P90D </pcrx:PurchaseOptionEventPeriodWithinWhichRightIsExercisableWhichRequiresEntityToRepurchaseRoyaltyInterestAssignment>
<us-gaap:DebtInstrumentInterestRateEffectivePercentage id="Tag609" decimals="4" contextRef="I2011_HerculesTermLoanMember" unitRef="Pure"> 0.1194 </us-gaap:DebtInstrumentInterestRateEffectivePercentage>
<us-gaap:ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights id="Tag610" decimals="INF" contextRef="I2010Q4_M1124_HerculesNoteMember" unitRef="Shares"> 178986 </us-gaap:ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights>
<pcrx:PurchaseOptionEventRepurchasePriceOfRoyaltyInterestAssignmentAsPercentageOfCumulativePaymentsMade id="Tag611" decimals="INF" contextRef="D2012_AffiliateOfPaulCapitalAdvisorsLLCMember" unitRef="Pure"> 0.50 </pcrx:PurchaseOptionEventRepurchasePriceOfRoyaltyInterestAssignmentAsPercentageOfCumulativePaymentsMade>
<pcrx:PurchaseOptionEventPeriodDuringWhichPaymentsWereMadeWhoseCumulativeAmountIsUsedForCalculatingRepurchasePriceOfRoyaltyInterestAssignment id="Tag612" contextRef="D2012_AffiliateOfPaulCapitalAdvisorsLLCMember"> P24M </pcrx:PurchaseOptionEventPeriodDuringWhichPaymentsWereMadeWhoseCumulativeAmountIsUsedForCalculatingRepurchasePriceOfRoyaltyInterestAssignment>
<pcrx:PurchaseOptionEventPeriodForCalculationOfRepurchasePrice id="Tag613" contextRef="D2012_AffiliateOfPaulCapitalAdvisorsLLCMember"> P365D </pcrx:PurchaseOptionEventPeriodForCalculationOfRepurchasePrice>
<us-gaap:ConcentrationRiskPercentage1 id="Tag615" decimals="2" contextRef="D2012_SalesRevenueGoodsNetMember_CustomerConcentrationRiskMember_CustomersOutsideUSMember" unitRef="Pure"> 0.23 </us-gaap:ConcentrationRiskPercentage1>
<us-gaap:StockholdersEquity id="Tag616" decimals="-3" contextRef="I2010" unitRef="USD"> -48383000 </us-gaap:StockholdersEquity>
<us-gaap:NumberOfReportableSegments id="Tag617" decimals="INF" contextRef="D2012" unitRef="Item"> 1 </us-gaap:NumberOfReportableSegments>
<us-gaap:DefinedContributionPlanCostRecognized id="Tag618" decimals="-5" contextRef="D2012" unitRef="USD"> 300000 </us-gaap:DefinedContributionPlanCostRecognized>
<us-gaap:Goodwill id="Tag619" decimals="-3" contextRef="I2012" unitRef="USD"> 8297000 </us-gaap:Goodwill>
<us-gaap:RoyaltyRevenue id="Tag620" decimals="-3" contextRef="D2010" unitRef="USD"> 3705000 </us-gaap:RoyaltyRevenue>
<pcrx:IncreaseDecreaseInRoyaltyInterestObligation id="Tag621" decimals="-3" contextRef="D2011" unitRef="USD"> 1815000 </pcrx:IncreaseDecreaseInRoyaltyInterestObligation>
<pcrx:IncreaseDecreaseInRoyaltyInterestObligation id="Tag622" decimals="-3" contextRef="D2010" unitRef="USD"> 675000 </pcrx:IncreaseDecreaseInRoyaltyInterestObligation>
<pcrx:PaymentOfContingentConsideration id="Tag623" decimals="-3" contextRef="D2012" unitRef="USD"> 10339000 </pcrx:PaymentOfContingentConsideration>
<us-gaap:RepaymentsOfDebt id="Tag624" decimals="-3" contextRef="D2012" unitRef="USD"> 26250000 </us-gaap:RepaymentsOfDebt>
<us-gaap:PaymentsOfFinancingCosts id="Tag625" decimals="-3" contextRef="D2012" unitRef="USD"> 1365000 </us-gaap:PaymentsOfFinancingCosts>
<us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis id="Tag626" decimals="-3" contextRef="I2011_USTreasurySecuritiesMember" unitRef="USD"> 1000000 </us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis>
<us-gaap:AvailableForSaleSecuritiesFairValueDisclosure id="Tag627" decimals="-3" contextRef="I2011_FairValueInputsLevel2Member_USTreasurySecuritiesMember" unitRef="USD"> 1000000 </us-gaap:AvailableForSaleSecuritiesFairValueDisclosure>
<us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis id="Tag628" decimals="-3" contextRef="I2011_CommercialPaperMember" unitRef="USD"> 11476000 </us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis>
<us-gaap:AvailableforsaleSecuritiesGrossUnrealizedGain id="Tag629" decimals="-3" contextRef="I2011_CommercialPaperMember" unitRef="USD"> 23000 </us-gaap:AvailableforsaleSecuritiesGrossUnrealizedGain>
<us-gaap:AvailableForSaleSecuritiesFairValueDisclosure id="Tag630" decimals="-3" contextRef="I2011_FairValueInputsLevel2Member_CommercialPaperMember" unitRef="USD"> 11499000 </us-gaap:AvailableForSaleSecuritiesFairValueDisclosure>
<us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis id="Tag631" decimals="-3" contextRef="I2011_CorporateBondSecuritiesMember" unitRef="USD"> 17494000 </us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis>
<us-gaap:AvailableforsaleSecuritiesGrossUnrealizedGain id="Tag632" decimals="-3" contextRef="I2011_CorporateBondSecuritiesMember" unitRef="USD"> 2000 </us-gaap:AvailableforsaleSecuritiesGrossUnrealizedGain>
<us-gaap:AvailableForSaleSecuritiesGrossUnrealizedLosses1 id="Tag633" decimals="-3" contextRef="I2011_CorporateBondSecuritiesMember" unitRef="USD"> 10000 </us-gaap:AvailableForSaleSecuritiesGrossUnrealizedLosses1>
<us-gaap:AvailableForSaleSecuritiesFairValueDisclosure id="Tag634" decimals="-3" contextRef="I2011_FairValueInputsLevel2Member_CorporateBondSecuritiesMember" unitRef="USD"> 17486000 </us-gaap:AvailableForSaleSecuritiesFairValueDisclosure>
<us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis id="Tag635" decimals="-3" contextRef="I2011" unitRef="USD"> 29970000 </us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis>
<us-gaap:AvailableforsaleSecuritiesGrossUnrealizedGain id="Tag636" decimals="-3" contextRef="I2011" unitRef="USD"> 25000 </us-gaap:AvailableforsaleSecuritiesGrossUnrealizedGain>
<us-gaap:AvailableForSaleSecuritiesGrossUnrealizedLosses1 id="Tag637" decimals="-3" contextRef="I2011" unitRef="USD"> 10000 </us-gaap:AvailableForSaleSecuritiesGrossUnrealizedLosses1>
<us-gaap:AvailableForSaleSecuritiesFairValueDisclosure id="Tag638" decimals="-3" contextRef="I2011_FairValueInputsLevel2Member" unitRef="USD"> 29985000 </us-gaap:AvailableForSaleSecuritiesFairValueDisclosure>
<pcrx:BeginningPeriodPriorToProductExpirationAllowedForReturningProduct id="Tag639" contextRef="D2012"> P6M </pcrx:BeginningPeriodPriorToProductExpirationAllowedForReturningProduct>
<pcrx:PeriodAfterProductExpirationUptoWhichProductIsAllowedToBeReturned id="Tag640" contextRef="D2012"> P12M </pcrx:PeriodAfterProductExpirationUptoWhichProductIsAllowedToBeReturned>
<pcrx:TerminationOfAgreementEffectivePeriodFromDateOfNotice id="Tag641" contextRef="D2012Q2_M06_NovoNordiskASMember"> P60D </pcrx:TerminationOfAgreementEffectivePeriodFromDateOfNotice>
<pcrx:InventoryValuationReserveOfProduct id="Tag642" decimals="-5" contextRef="I2012" unitRef="USD"> 300000 </pcrx:InventoryValuationReserveOfProduct>
<us-gaap:InterestCostsCapitalized id="Tag643" decimals="-5" contextRef="D2012" unitRef="USD"> 200000 </us-gaap:InterestCostsCapitalized>
<pcrx:AgreedMilestonePaymentsForSaleOfProductInConnectionWithAcquisition id="Tag644" decimals="-5" contextRef="I2012_UponFirstCommercialSaleInUnitedStatesMember" unitRef="USD"> 10000000 </pcrx:AgreedMilestonePaymentsForSaleOfProductInConnectionWithAcquisition>
<pcrx:AgreedMilestonePaymentsForSaleOfProductInConnectionWithAcquisition id="Tag645" decimals="-5" contextRef="I2012_UponFirstCommercialSaleInMajorEUCountryMember" unitRef="USD"> 4000000 </pcrx:AgreedMilestonePaymentsForSaleOfProductInConnectionWithAcquisition>
<pcrx:AgreedMilestonePaymentsForSaleOfProductInConnectionWithAcquisition id="Tag646" decimals="-5" contextRef="I2012_UponAnnualNetSalesReachingDollar100.0MillionThresholdMember" unitRef="USD"> 8000000 </pcrx:AgreedMilestonePaymentsForSaleOfProductInConnectionWithAcquisition>
<pcrx:AgreedMilestonePaymentsForSaleOfProductInConnectionWithAcquisition id="Tag647" decimals="-5" contextRef="I2012_UponAnnualNetSalesReachingDollar250.0MillionThresholdMember" unitRef="USD"> 8000000 </pcrx:AgreedMilestonePaymentsForSaleOfProductInConnectionWithAcquisition>
<pcrx:AgreedMilestonePaymentsForSaleOfProductInConnectionWithAcquisition id="Tag648" decimals="-5" contextRef="I2012_UponAnnualNetSalesReachingDollar500.0MillionThresholdMember" unitRef="USD"> 32000000 </pcrx:AgreedMilestonePaymentsForSaleOfProductInConnectionWithAcquisition>
<pcrx:AnnualNetSalesThresholdForDeterminingMilestonePaymentsForProductInConnectionWithAcquisition id="Tag649" decimals="-5" contextRef="I2012_UponAnnualNetSalesReachingDollar100.0MillionThresholdMember" unitRef="USD"> 100000000 </pcrx:AnnualNetSalesThresholdForDeterminingMilestonePaymentsForProductInConnectionWithAcquisition>
<pcrx:AnnualNetSalesThresholdForDeterminingMilestonePaymentsForProductInConnectionWithAcquisition id="Tag650" decimals="-5" contextRef="I2012_UponAnnualNetSalesReachingDollar250.0MillionThresholdMember" unitRef="USD"> 250000000 </pcrx:AnnualNetSalesThresholdForDeterminingMilestonePaymentsForProductInConnectionWithAcquisition>
<pcrx:AnnualNetSalesThresholdForDeterminingMilestonePaymentsForProductInConnectionWithAcquisition id="Tag651" decimals="-5" contextRef="I2012_UponAnnualNetSalesReachingDollar500.0MillionThresholdMember" unitRef="USD"> 500000000 </pcrx:AnnualNetSalesThresholdForDeterminingMilestonePaymentsForProductInConnectionWithAcquisition>
<pcrx:PaymentObligationArisingDueToFirstCommercialSaleOfProductInConnectionWithAcquisition id="Tag652" decimals="-5" contextRef="I2012Q2_M0430" unitRef="USD"> 10000000 </pcrx:PaymentObligationArisingDueToFirstCommercialSaleOfProductInConnectionWithAcquisition>
<us-gaap:Goodwill id="Tag653" decimals="-5" contextRef="I2012Q2_M0430" unitRef="USD"> 8000000 </us-gaap:Goodwill>
<pcrx:GoodwillRecordedForEarnOutPayments id="Tag654" decimals="-5" contextRef="I2012" unitRef="USD"> 300000 </pcrx:GoodwillRecordedForEarnOutPayments>
<pcrx:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorizedPriorToAmendment id="Tag655" decimals="INF" contextRef="I2012" unitRef="Shares"> 1729498 </pcrx:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorizedPriorToAmendment>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber id="Tag656" decimals="INF" contextRef="I2009_StockOptionsMember" unitRef="Shares"> 52430 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross id="Tag657" decimals="INF" contextRef="D2010_StockOptionsMember_S" unitRef="Shares"> 2028158 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross>
<us-gaap:StockIssuedDuringPeriodSharesStockOptionsExercised id="Tag658" decimals="INF" contextRef="D2010_StockOptionsMember_S" unitRef="Shares"> 1177 </us-gaap:StockIssuedDuringPeriodSharesStockOptionsExercised>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod id="Tag659" decimals="INF" contextRef="D2010_StockOptionsMember_S" unitRef="Shares"> 3337 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod id="Tag660" decimals="INF" contextRef="D2010_StockOptionsMember_S" unitRef="Shares"> 2374 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod>
<us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice id="Tag661" decimals="2" contextRef="D2010_StockOptionsMember_S" unitRef="USDPerShare"> 2.71 </us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice>
<us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice id="Tag662" decimals="2" contextRef="D2010_StockOptionsMember_S" unitRef="USDPerShare"> 1.89 </us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice>
<us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice id="Tag663" decimals="2" contextRef="D2010_StockOptionsMember_S" unitRef="USDPerShare"> 1.89 </us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice>
<us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice id="Tag664" decimals="2" contextRef="D2010_StockOptionsMember_S" unitRef="USDPerShare"> 1.75 </us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice>
<us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2 id="Tag665" contextRef="D2009_StockOptionsMember"> P8Y22D </us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue id="Tag666" decimals="-3" contextRef="I2009_StockOptionsMember" unitRef="USD"> 47000 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue id="Tag667" decimals="-3" contextRef="D2010_StockOptionsMember_S" unitRef="USD"> 1000 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber id="Tag668" decimals="INF" contextRef="I2012_StockOptionsMember" unitRef="Shares"> 1269921 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber id="Tag669" decimals="INF" contextRef="I2012_StockOptionsMember" unitRef="Shares"> 3889392 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice id="Tag670" decimals="2" contextRef="I2012_StockOptionsMember" unitRef="USDPerShare"> 3.76 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice id="Tag671" decimals="2" contextRef="I2012_StockOptionsMember" unitRef="USDPerShare"> 7.78 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice>
<us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1 id="Tag672" contextRef="D2012_StockOptionsMember_S"> P7Y9M18D </us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1>
<us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1 id="Tag673" contextRef="D2012_StockOptionsMember_S"> P8Y7M20D </us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1>
<us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2 id="Tag674" contextRef="D2011_StockOptionsMember_S"> P8Y9M18D </us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2>
<us-gaap:ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights id="Tag675" decimals="2" contextRef="I2012" unitRef="USDPerShare"> 10.79 </us-gaap:ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights>
<us-gaap:ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights id="Tag676" decimals="2" contextRef="I2012_OxfordNoteMember" unitRef="USDPerShare"> 10.97 </us-gaap:ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights>
<us-gaap:FairValueInputsDiscountRate id="Tag677" decimals="4" contextRef="D2012_OxfordNoteMember" unitRef="Pure"> 0.0196 </us-gaap:FairValueInputsDiscountRate>
<us-gaap:FairValueAssumptionsExpectedVolatilityRate id="Tag678" decimals="4" contextRef="D2012_OxfordNoteMember" unitRef="Pure"> 0.6969 </us-gaap:FairValueAssumptionsExpectedVolatilityRate>
<us-gaap:FairValueAssumptionsExpectedDividendRate id="Tag679" decimals="2" contextRef="D2012_OxfordNoteMember" unitRef="Pure"> 0.00 </us-gaap:FairValueAssumptionsExpectedDividendRate>
<us-gaap:FairValueAssumptionsExpectedTerm id="Tag680" contextRef="D2012_OxfordNoteMember"> P10Y </us-gaap:FairValueAssumptionsExpectedTerm>
<us-gaap:LongTermDebtFairValue id="Tag681" decimals="-5" contextRef="I2012_OxfordNoteMember" unitRef="USD"> 1400000 </us-gaap:LongTermDebtFairValue>
<us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1 id="Tag682" decimals="-3" contextRef="I2012_StockOptionsMember" unitRef="USD"> 17415000 </us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue id="Tag683" decimals="-3" contextRef="I2012_StockOptionsMember" unitRef="USD"> 37686000 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue>
<us-gaap:SalesRevenueGoodsNet id="Tag684" decimals="-3" contextRef="D2011" unitRef="USD"> 6895000 </us-gaap:SalesRevenueGoodsNet>
<us-gaap:SalesRevenueGoodsNet id="Tag685" decimals="-3" contextRef="D2010" unitRef="USD"> 7640000 </us-gaap:SalesRevenueGoodsNet>
<pcrx:DebtIssuanceOnIssuanceOfWarrantsValue id="Tag686" decimals="-3" contextRef="D2012_AdditionalPaidInCapitalMember" unitRef="USD"> 1354000 </pcrx:DebtIssuanceOnIssuanceOfWarrantsValue>
<us-gaap:ProceedsFromIssuanceOfLongTermDebt id="Tag687" decimals="-3" contextRef="D2012" unitRef="USD"> 27500000 </us-gaap:ProceedsFromIssuanceOfLongTermDebt>
<pcrx:ClassOfWarrantOrRightValueOfWarrantIssuedWithDebt id="Tag688" decimals="-3" contextRef="D2012" unitRef="USD"> 1354000 </pcrx:ClassOfWarrantOrRightValueOfWarrantIssuedWithDebt>
<us-gaap:DebtInstrumentUnamortizedDiscount id="Tag689" decimals="-3" contextRef="I2011" unitRef="USD"> 674000 </us-gaap:DebtInstrumentUnamortizedDiscount>
<us-gaap:DebtInstrumentUnamortizedDiscount id="Tag690" decimals="-3" contextRef="I2012" unitRef="USD"> 2309000 </us-gaap:DebtInstrumentUnamortizedDiscount>
<pcrx:RoyaltyInterestObligation id="Tag691" decimals="-3" contextRef="I2011" unitRef="USD"> 2756000 </pcrx:RoyaltyInterestObligation>
<pcrx:RoyaltyInterestObligation id="Tag692" decimals="-3" contextRef="I2012" unitRef="USD"> 1680000 </pcrx:RoyaltyInterestObligation>
<us-gaap:DebtInstrumentIncreaseAdditionalBorrowings id="Tag693" decimals="-5" contextRef="D2012Q2_M05_OxfordNoteMember" unitRef="USD"> 27500000 </us-gaap:DebtInstrumentIncreaseAdditionalBorrowings>
<us-gaap:DebtInstrumentInterestRateStatedPercentage id="Tag694" decimals="INF" contextRef="I2012Q2_M0502_OxfordNoteMember" unitRef="Pure"> 0.0975 </us-gaap:DebtInstrumentInterestRateStatedPercentage>
<pcrx:NumberOfEqualMonthlyPayments id="Tag695" decimals="INF" contextRef="D2012Q2_M05_OxfordNoteMember" unitRef="Item"> 30 </pcrx:NumberOfEqualMonthlyPayments>
<pcrx:AdditionalLoanPaymentAsAPercentageOfLoanFacilityOnMaturityDate id="Tag696" decimals="2" contextRef="D2012Q2_M05_OxfordNoteMember" unitRef="Pure"> 0.06 </pcrx:AdditionalLoanPaymentAsAPercentageOfLoanFacilityOnMaturityDate>
<us-gaap:DebtInstrumentUnamortizedDiscount id="Tag697" decimals="-4" contextRef="I2012Q2_M0502_OxfordNoteMember" unitRef="USD"> 1650000 </us-gaap:DebtInstrumentUnamortizedDiscount>
<us-gaap:DebtInstrumentDecreaseRepayments id="Tag698" decimals="-5" contextRef="D2012_HerculesNoteMember" unitRef="USD"> 24200000 </us-gaap:DebtInstrumentDecreaseRepayments>
<pcrx:DebtInstrumentProceedsUsedToRepayEndOfTermFee id="Tag699" decimals="-5" contextRef="D2012_HerculesNoteMember" unitRef="USD"> 600000 </pcrx:DebtInstrumentProceedsUsedToRepayEndOfTermFee>
<pcrx:DebtInstrumentProceedsUsedToRepayEarlyPrepaymentPenalty id="Tag700" decimals="-5" contextRef="D2012_HerculesNoteMember" unitRef="USD"> 300000 </pcrx:DebtInstrumentProceedsUsedToRepayEarlyPrepaymentPenalty>
<us-gaap:GainsLossesOnExtinguishmentOfDebt id="Tag701" decimals="-5" contextRef="D2012_HerculesNoteMember" unitRef="USD"> 1100000 </us-gaap:GainsLossesOnExtinguishmentOfDebt>
<pcrx:PercentageOfPrepaymentFeeIfPrepaymentOccursWithinFirstAnniversaryOfFundingDate id="Tag702" decimals="2" contextRef="D2012_OxfordNoteMember" unitRef="Pure"> 0.03 </pcrx:PercentageOfPrepaymentFeeIfPrepaymentOccursWithinFirstAnniversaryOfFundingDate>
<pcrx:PercentageOfPrepaymentFeeIfPrepaymentOccursBetweenFirstAndSecondAnniversaryOfFundingDate id="Tag703" decimals="2" contextRef="D2012_OxfordNoteMember" unitRef="Pure"> 0.02 </pcrx:PercentageOfPrepaymentFeeIfPrepaymentOccursBetweenFirstAndSecondAnniversaryOfFundingDate>
<pcrx:PercentageOfPrepaymentFeeIfPrepaymentOccursAfterSecondAnniversaryOfFundingDate id="Tag704" decimals="2" contextRef="D2012_OxfordNoteMember" unitRef="Pure"> 0.01 </pcrx:PercentageOfPrepaymentFeeIfPrepaymentOccursAfterSecondAnniversaryOfFundingDate>
<pcrx:DebtDefaultIncreaseInInterestRate id="Tag705" decimals="2" contextRef="D2012_OxfordNoteMember" unitRef="Pure"> 0.05 </pcrx:DebtDefaultIncreaseInInterestRate>
<us-gaap:ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights id="Tag706" decimals="INF" contextRef="I2012_OxfordNoteMember" unitRef="Shares"> 162885 </us-gaap:ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights>
<us-gaap:GainsLossesOnExtinguishmentOfDebt id="Tag707" decimals="-3" contextRef="D2012" unitRef="USD"> -1062000 </us-gaap:GainsLossesOnExtinguishmentOfDebt>
<us-gaap:AmortizationOfDebtDiscountPremium id="Tag708" decimals="-3" contextRef="D2011" unitRef="USD"> 1644000 </us-gaap:AmortizationOfDebtDiscountPremium>
<us-gaap:AmortizationOfDebtDiscountPremium id="Tag709" decimals="-3" contextRef="D2010" unitRef="USD"> 146000 </us-gaap:AmortizationOfDebtDiscountPremium>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber id="Tag710" decimals="INF" contextRef="I2012_StockOptionsMember" unitRef="Shares"> 4003166 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice id="Tag711" decimals="2" contextRef="I2012_StockOptionsMember" unitRef="USDPerShare"> 7.86 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross id="Tag712" decimals="INF" contextRef="D2012_StockOptionsMember_S" unitRef="Shares"> 2120250 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross>
<us-gaap:StockIssuedDuringPeriodSharesStockOptionsExercised id="Tag713" decimals="INF" contextRef="D2012_StockOptionsMember_S" unitRef="Shares"> 279476 </us-gaap:StockIssuedDuringPeriodSharesStockOptionsExercised>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod id="Tag714" decimals="INF" contextRef="D2012_StockOptionsMember_S" unitRef="Shares"> 174610 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod id="Tag715" decimals="INF" contextRef="D2012_StockOptionsMember_S" unitRef="Shares"> 15 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod>
<us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice id="Tag716" decimals="2" contextRef="D2012_StockOptionsMember_S" unitRef="USDPerShare"> 11.55 </us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice>
<us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice id="Tag717" decimals="2" contextRef="D2012_StockOptionsMember_S" unitRef="USDPerShare"> 2.75 </us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice>
<us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice id="Tag718" decimals="2" contextRef="D2012_StockOptionsMember_S" unitRef="USDPerShare"> 7.94 </us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice>
<us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice id="Tag719" decimals="2" contextRef="D2012_StockOptionsMember_S" unitRef="USDPerShare"> 7.07 </us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice>
<us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2 id="Tag720" contextRef="D2012_StockOptionsMember_S"> P8Y7M28D </us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue id="Tag721" decimals="-3" contextRef="D2012_StockOptionsMember_S" unitRef="USD"> 3005000 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice id="Tag722" decimals="2" contextRef="I2009_StockOptionsMember" unitRef="USDPerShare"> 1.79 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice>
<us-gaap:ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock id="Tag724" contextRef="D2012">
<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"> </p> <div align="center"> <table style="WIDTH: 701px; HEIGHT: 3px" cellspacing="0" cellpadding="0" width="701" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="center" width="73"></td> <td style="FONT-FAMILY: times" width="14"></td> <td style="FONT-FAMILY: times" align="center" width="60"></td> <td style="FONT-FAMILY: times" width="14"></td> <td style="FONT-FAMILY: times" align="center" width="60"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="5"><font size="1"><b>Year Ended December 31,</b></font></th></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="1"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center"><font size="1"><b>2012</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center"><font size="1"><b>2011</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center"><font size="1"><b>2010</b></font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Expected dividend yield</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">None</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">None</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">None</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Risk free interest rate</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">0.84 - 1.70%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">1.1 - 2.7%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">1.6 - 3.4%</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Expected volatility</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">74.0%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">76.8%</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">80.8%</font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Expected life of options</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">6.76 years</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">6.73 years</font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="center"><font size="2">6.25 years</font></td></tr></table></div> <!-- end of user-specified TAGGED TABLE --></div></div>
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<pcrx:DebtInstrumentSpecifiedPercentageOfReferenceRateExcessOfWhichIsAddedToFloatingRate id="Tag725" decimals="INF" contextRef="D2010Q4_M1124_TrancheBOfTermLoanMember" unitRef="Pure"> 0.0400 </pcrx:DebtInstrumentSpecifiedPercentageOfReferenceRateExcessOfWhichIsAddedToFloatingRate>
<pcrx:DebtInstrumentSpecifiedPercentageOfReferenceRateExcessOfWhichIsAddedToFloatingRate id="Tag726" decimals="4" contextRef="D2010Q4_M1124_TrancheAOfTermLoanMember" unitRef="Pure"> 0.0400 </pcrx:DebtInstrumentSpecifiedPercentageOfReferenceRateExcessOfWhichIsAddedToFloatingRate>
<pcrx:LongTermDebtNoncurrentGross id="Tag727" decimals="-3" contextRef="I2011" unitRef="USD"> 19211000 </pcrx:LongTermDebtNoncurrentGross>
<pcrx:LongTermDebtNoncurrentGross id="Tag728" decimals="-3" contextRef="I2012" unitRef="USD"> 27500000 </pcrx:LongTermDebtNoncurrentGross>
<us-gaap:LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths id="Tag729" decimals="-5" contextRef="I2012_OxfordNoteMember" unitRef="USD"> 800000 </us-gaap:LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths>
<us-gaap:LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo id="Tag730" decimals="-5" contextRef="I2012_OxfordNoteMember" unitRef="USD"> 10300000 </us-gaap:LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo>
<us-gaap:LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree id="Tag731" decimals="-5" contextRef="I2012_OxfordNoteMember" unitRef="USD"> 11300000 </us-gaap:LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree>
<us-gaap:LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour id="Tag732" decimals="-5" contextRef="I2012_OxfordNoteMember" unitRef="USD"> 5100000 </us-gaap:LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour>
<us-gaap:DebtInstrumentCarryingAmount id="Tag733" decimals="-5" contextRef="I2012_HerculesTermLoanMember" unitRef="USD"> 0 </us-gaap:DebtInstrumentCarryingAmount>
<us-gaap:LongTermDebt id="Tag734" decimals="-3" contextRef="I2011" unitRef="USD"> 25576000 </us-gaap:LongTermDebt>
<us-gaap:LongTermDebt id="Tag735" decimals="-3" contextRef="I2012" unitRef="USD"> 25191000 </us-gaap:LongTermDebt>
<us-gaap:ConcentrationRiskPercentage1 id="Tag736" decimals="2" contextRef="D2012_AccountsReceivableMember_CreditConcentrationRiskMember_MajorCustomerThreeMember" unitRef="Pure"> 0.16 </us-gaap:ConcentrationRiskPercentage1>
<us-gaap:ConcentrationRiskPercentage1 id="Tag737" decimals="2" contextRef="D2012_AccountsReceivableMember_CreditConcentrationRiskMember_MajorCustomerFourMember" unitRef="Pure"> 0.15 </us-gaap:ConcentrationRiskPercentage1>
<us-gaap:InventoryWriteDown id="Tag738" decimals="-5" contextRef="D2012" unitRef="USD"> 200000 </us-gaap:InventoryWriteDown>
<pcrx:AccruedEndOfTermFeeCurrent id="Tag739" decimals="-3" contextRef="I2012" unitRef="USD"> 1873000 </pcrx:AccruedEndOfTermFeeCurrent>
<pcrx:AccruedEndOfTermFeeCurrent id="Tag740" decimals="-3" contextRef="I2011" unitRef="USD"> 900000 </pcrx:AccruedEndOfTermFeeCurrent>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue id="Tag741" decimals="-3" contextRef="I2012_StockOptionsMember" unitRef="USD"> 38485000 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue>
<us-gaap:DefinedContributionPlanCostRecognized id="Tag742" decimals="-5" contextRef="D2010" unitRef="USD"> 0 </us-gaap:DefinedContributionPlanCostRecognized>
<us-gaap:RestrictedCashAndCashEquivalentsAtCarryingValue id="Tag743" decimals="-3" contextRef="I2012" unitRef="USD"> 1523000 </us-gaap:RestrictedCashAndCashEquivalentsAtCarryingValue>
<us-gaap:AccountsReceivableNetCurrent id="Tag744" decimals="-3" contextRef="I2012" unitRef="USD"> 4352000 </us-gaap:AccountsReceivableNetCurrent>
<us-gaap:PrepaidExpenseAndOtherAssetsCurrent id="Tag745" decimals="-3" contextRef="I2012" unitRef="USD"> 1920000 </us-gaap:PrepaidExpenseAndOtherAssetsCurrent>
<us-gaap:OtherAssetsNoncurrent id="Tag746" decimals="-3" contextRef="I2012" unitRef="USD"> 511000 </us-gaap:OtherAssetsNoncurrent>
<us-gaap:AccountsPayableCurrent id="Tag747" decimals="-3" contextRef="I2012" unitRef="USD"> 2569000 </us-gaap:AccountsPayableCurrent>
<us-gaap:DeferredRevenueCurrent id="Tag748" decimals="-3" contextRef="I2012" unitRef="USD"> 972000 </us-gaap:DeferredRevenueCurrent>
<us-gaap:LongTermDebtNoncurrent id="Tag749" decimals="-3" contextRef="I2012" unitRef="USD"> 25191000 </us-gaap:LongTermDebtNoncurrent>
<us-gaap:DeferredRevenueNoncurrent id="Tag750" decimals="-3" contextRef="I2012" unitRef="USD"> 3720000 </us-gaap:DeferredRevenueNoncurrent>
<us-gaap:OtherLiabilitiesNoncurrent id="Tag751" decimals="-3" contextRef="I2012" unitRef="USD"> 2275000 </us-gaap:OtherLiabilitiesNoncurrent>
<us-gaap:AdditionalPaidInCapital id="Tag752" decimals="-3" contextRef="I2012" unitRef="USD"> 298317000 </us-gaap:AdditionalPaidInCapital>
<us-gaap:RetainedEarningsAccumulatedDeficit id="Tag753" decimals="-3" contextRef="I2012" unitRef="USD"> -232520000 </us-gaap:RetainedEarningsAccumulatedDeficit>
<us-gaap:AccumulatedOtherComprehensiveIncomeLossNetOfTax id="Tag754" decimals="-3" contextRef="I2012" unitRef="USD"> 27000 </us-gaap:AccumulatedOtherComprehensiveIncomeLossNetOfTax>
<us-gaap:TreasuryStockValue id="Tag755" decimals="-3" contextRef="I2012" unitRef="USD"> 2000 </us-gaap:TreasuryStockValue>
<us-gaap:SalesRevenueGoodsNet id="Tag756" decimals="-3" contextRef="D2012" unitRef="USD"> 18191000 </us-gaap:SalesRevenueGoodsNet>
<pcrx:CollaborativeLicensingAndDevelopmentRevenue id="Tag757" decimals="-3" contextRef="D2012" unitRef="USD"> 18390000 </pcrx:CollaborativeLicensingAndDevelopmentRevenue>
<us-gaap:RoyaltyRevenue id="Tag758" decimals="-3" contextRef="D2012" unitRef="USD"> 2503000 </us-gaap:RoyaltyRevenue>
<us-gaap:ResearchAndDevelopmentExpense id="Tag759" decimals="-3" contextRef="D2012" unitRef="USD"> 9937000 </us-gaap:ResearchAndDevelopmentExpense>
<us-gaap:SellingGeneralAndAdministrativeExpense id="Tag760" decimals="-3" contextRef="D2012" unitRef="USD"> 46306000 </us-gaap:SellingGeneralAndAdministrativeExpense>
<us-gaap:InvestmentIncomeInterest id="Tag761" decimals="-3" contextRef="D2012" unitRef="USD"> 275000 </us-gaap:InvestmentIncomeInterest>
<us-gaap:InterestExpense id="Tag762" decimals="-3" contextRef="D2012" unitRef="USD"> 1807000 </us-gaap:InterestExpense>
<us-gaap:RoyaltyExpense id="Tag763" decimals="-3" contextRef="D2012" unitRef="USD"> 278000 </us-gaap:RoyaltyExpense>
<us-gaap:OtherNonoperatingIncomeExpense id="Tag764" decimals="-3" contextRef="D2012" unitRef="USD"> -111000 </us-gaap:OtherNonoperatingIncomeExpense>
<us-gaap:OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent id="Tag765" decimals="-3" contextRef="D2012" unitRef="USD"> 12000 </us-gaap:OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent>
<us-gaap:OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent id="Tag766" decimals="-3" contextRef="D2011" unitRef="USD"> 15000 </us-gaap:OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent>
<us-gaap:ComprehensiveIncomeNetOfTax id="Tag767" decimals="-3" contextRef="D2012" unitRef="USD"> -52269000 </us-gaap:ComprehensiveIncomeNetOfTax>
<us-gaap:ComprehensiveIncomeNetOfTax id="Tag768" decimals="-3" contextRef="D2011" unitRef="USD"> -43313000 </us-gaap:ComprehensiveIncomeNetOfTax>
<us-gaap:ComprehensiveIncomeNetOfTax id="Tag769" decimals="-3" contextRef="D2010" unitRef="USD"> -27149000 </us-gaap:ComprehensiveIncomeNetOfTax>
<pcrx:StockIssuedDuringPeriodSharesWarrantsExercised id="Tag770" decimals="INF" contextRef="D2012_CommonStockMember" unitRef="Shares"> 105 </pcrx:StockIssuedDuringPeriodSharesWarrantsExercised>
<pcrx:StockIssuedDuringPeriodValueWarrantsExercised id="Tag771" decimals="-3" contextRef="D2012_AdditionalPaidInCapitalMember" unitRef="USD"> 100000 </pcrx:StockIssuedDuringPeriodValueWarrantsExercised>
<pcrx:StockIssuedDuringPeriodValueWarrantsExercised id="Tag772" decimals="-3" contextRef="D2012" unitRef="USD"> 100000 </pcrx:StockIssuedDuringPeriodValueWarrantsExercised>
<pcrx:DebtIssuanceOnIssuanceOfWarrantsValue id="Tag773" decimals="-3" contextRef="D2012" unitRef="USD"> 1354000 </pcrx:DebtIssuanceOnIssuanceOfWarrantsValue>
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<div style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman"> <div style="PADDING-RIGHT: 0pt; PADDING-LEFT: 0pt; PADDING-BOTTOM: 0pt; MARGIN-LEFT: 15%; WIDTH: 70%; PADDING-TOP: 0pt; POSITION: relative"> <p style="FONT-FAMILY: times"> </p> <div align="center"> <table style="WIDTH: 799px; HEIGHT: 142px" cellspacing="0" cellpadding="0" width="799" border="0"> <tr style="HEIGHT: 0px"><!-- TABLE COLUMN WIDTHS SET --> <td style="FONT-FAMILY: times" align="left"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="101"></td> <td style="FONT-FAMILY: times" width="12"></td> <td style="FONT-FAMILY: times" align="right" width="7"></td> <td style="FONT-FAMILY: times" width="101"></td> <td style="FONT-FAMILY: times" width="12"></td><!-- TABLE COLUMN WIDTHS END --></tr> <tr style="HEIGHT: 0px" valign="bottom"> <th style="FONT-FAMILY: times" align="left"><font size="2"> </font><br /></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Net Unrealized Gains<br /> (Losses) From<br /> Marketable Securities</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th> <th style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" align="center" colspan="2"><font size="1"><b>Total Accumulated<br /> Other Comprehesive<br /> Income (Loss)</b></font></th> <th style="FONT-FAMILY: times"><font size="1"> </font></th></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Balances at December 31, 2010</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$—  </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$—  </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Period Change</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">15  </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">15  </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Balances at December 31, 2011</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$15  </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$15  </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="white"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Period Change</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">12  </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">12  </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 1pt solid; FONT-FAMILY: times" valign="bottom" align="right" colspan="2"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td></tr> <tr style="HEIGHT: 0px" valign="top" bgcolor="#CCEEFF"> <td style="FONT-FAMILY: times" valign="bottom"> <p style="MARGIN-LEFT: 10pt; TEXT-INDENT: -10pt; FONT-FAMILY: times"><font size="2">Balances at December 31, 2012</font></p></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$27  </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td> <td style="FONT-FAMILY: times" valign="bottom" align="right"><font size="2">$27  </font></td> <td style="FONT-FAMILY: times" valign="bottom"><font size="2"> </font></td></tr> <tr style="FONT-SIZE: 1.5pt; HEIGHT: 0px" valign="top"> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="FONT-FAMILY: times" valign="bottom"> </td> <td style="BORDER-BOTTOM: #000000 2.25pt double; 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<us-gaap:OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax id="Tag775" decimals="-3" contextRef="D2011" unitRef="USD"> 15000 </us-gaap:OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax>
<us-gaap:AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax id="Tag776" decimals="-3" contextRef="I2011" unitRef="USD"> 15000 </us-gaap:AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax>
<us-gaap:OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax id="Tag777" decimals="-3" contextRef="D2012" unitRef="USD"> 12000 </us-gaap:OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax>
<us-gaap:AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax id="Tag778" decimals="-3" contextRef="I2012" unitRef="USD"> 27000 </us-gaap:AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax>
<us-gaap:ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights id="Tag779" decimals="INF" contextRef="I2012Q2_M0502" unitRef="Shares"> 162885 </us-gaap:ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights>
<us-gaap:ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights id="Tag780" decimals="2" contextRef="I2012Q2_M0502" unitRef="USDPerShare"> 10.97 </us-gaap:ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights>
<us-gaap:ClassOfWarrantOrRightOutstanding id="Tag781" decimals="INF" contextRef="I2012" unitRef="Shares"> 490464 </us-gaap:ClassOfWarrantOrRightOutstanding>
<us-gaap:ClassOfWarrantOrRightOutstanding id="Tag782" decimals="INF" contextRef="I2011" unitRef="Shares"> 527656 </us-gaap:ClassOfWarrantOrRightOutstanding>
<us-gaap:ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights id="Tag783" decimals="2" contextRef="I2011" unitRef="USDPerShare"> 10.22 </us-gaap:ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights>
<us-gaap:TaxCreditCarryforwardAmount id="Tag784" decimals="-5" contextRef="I2013Q1_InternalRevenueServiceIRSMember_ResearchMember" unitRef="USD"> 200000 </us-gaap:TaxCreditCarryforwardAmount>
<pcrx:CollaborativeArrangementUpfrontPaymentReceived id="Tag785" decimals="-5" contextRef="D2012Q4_M1205_AratanaTherapeuticsIncMember" unitRef="USD"> 1000000 </pcrx:CollaborativeArrangementUpfrontPaymentReceived>
<pcrx:CollaborativeArrangementMilestonePaymentsToBeReceived id="Tag786" decimals="-5" contextRef="I2012Q4_M1205_AratanaTherapeuticsIncMember_MaximumMember_AchievementOfDevelopmentAndCommercialMilestonesMember" unitRef="USD"> 42500000 </pcrx:CollaborativeArrangementMilestonePaymentsToBeReceived>
<us-gaap:DebtInstrumentIncreaseAdditionalBorrowings id="Tag787" decimals="-5" contextRef="D2013Q1_M0123_SubsequentEventMember_TwoThousandNineteenSeniorConvertibleNotesMember" unitRef="USD"> 120000000 </us-gaap:DebtInstrumentIncreaseAdditionalBorrowings>
<us-gaap:DebtInstrumentInterestRateStatedPercentage id="Tag788" decimals="INF" contextRef="I2013Q1_M0123_SubsequentEventMember_TwoThousandNineteenSeniorConvertibleNotesMember" unitRef="Pure"> 0.0325 </us-gaap:DebtInstrumentInterestRateStatedPercentage>
<us-gaap:ProceedsFromDebtNetOfIssuanceCosts id="Tag789" decimals="-5" contextRef="D2013Q1_M0123_SubsequentEventMember_TwoThousandNineteenSeniorConvertibleNotesMember" unitRef="USD"> 115300000 </us-gaap:ProceedsFromDebtNetOfIssuanceCosts>
<us-gaap:DebtInstrumentInterestRateEffectivePercentage id="Tag790" decimals="4" contextRef="I2013Q1_M0123_SubsequentEventMember_TwoThousandNineteenSeniorConvertibleNotesMember" unitRef="Pure"> 0.0325 </us-gaap:DebtInstrumentInterestRateEffectivePercentage>
<us-gaap:DebtInstrumentDecreaseRepayments id="Tag791" decimals="-5" contextRef="D2013Q1_M0123_SubsequentEventMember_OxfordNoteMember" unitRef="USD"> 27500000 </us-gaap:DebtInstrumentDecreaseRepayments>
<pcrx:DebtInstrumentDecreaseRepaymentsOfRemainingPrincipalAmount id="Tag792" decimals="-5" contextRef="D2013Q1_M0123_SubsequentEventMember_OxfordNoteMember" unitRef="USD"> 27500000 </pcrx:DebtInstrumentDecreaseRepaymentsOfRemainingPrincipalAmount>
<pcrx:DebtInstrumentEndOfTermCharge id="Tag793" decimals="-5" contextRef="I2013Q1_M0123_SubsequentEventMember_OxfordNoteMember" unitRef="USD"> 2600000 </pcrx:DebtInstrumentEndOfTermCharge>
<pcrx:DebtInstrumentProceedsUsedToRepayCreditFacility id="Tag794" decimals="-5" contextRef="D2013Q1_M0123_SubsequentEventMember_OxfordNoteMember" unitRef="USD"> 30100000 </pcrx:DebtInstrumentProceedsUsedToRepayCreditFacility>
<us-gaap:NetRentableArea id="Tag795" decimals="INF" contextRef="I2011Q3_M0831" unitRef="Square_Foot"> 13000 </us-gaap:NetRentableArea>
<us-gaap:NetRentableArea id="Tag796" decimals="INF" contextRef="I2012" unitRef="Square_Foot"> 106000 </us-gaap:NetRentableArea>
<us-gaap:LossContingencyLossInPeriod id="Tag797" decimals="-5" contextRef="D2012_UnfavorableRegulatoryActionMember" unitRef="USD"> 1300000 </us-gaap:LossContingencyLossInPeriod>
<pcrx:ManagementAgreementContractSum id="Tag798" decimals="-5" contextRef="D2012Q2_M05" unitRef="USD"> 7700000 </pcrx:ManagementAgreementContractSum>
<pcrx:MinimumAgeOfPediatricPatientsToStudyEXPAREL id="Tag799" decimals="INF" contextRef="I2012" unitRef="Item"> 12 </pcrx:MinimumAgeOfPediatricPatientsToStudyEXPAREL>
<pcrx:MaximumAgeOfPediatricPatientsToStudyEXPAREL id="Tag800" decimals="INF" contextRef="I2012" unitRef="Item"> 18 </pcrx:MaximumAgeOfPediatricPatientsToStudyEXPAREL>
<pcrx:AgeOfChildrenPediatricPatientsToStudyEXPAREL id="Tag801" decimals="INF" contextRef="I2012" unitRef="Item"> 2 </pcrx:AgeOfChildrenPediatricPatientsToStudyEXPAREL>
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<div style='font-size:10.0pt;FONT-FAMILY: Times New Roman;'> <p style="FONT-FAMILY: times"><font size="2"><b><i>Goodwill and Intangible Assets</i></b></font></p> <p style="FONT-FAMILY: times"><font size="2">        Intangible assets are recorded at cost, net of accumulated amortization. Amortization of intangible assets is provided over their estimated useful lives on a straight-line basis. The Company evaluates the recoverability of intangible assets periodically and takes into account events and circumstances which indicate that impairment exists. Goodwill represents the excess of purchase price over fair value acquired in a business combination and is not amortized, but subject to impairment at least annually or when a triggering event occurs that could indicate a potential impairment.</font></p></div>
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<pcrx:RelatedPartyTransactionFeePayablePerMonth id="Tag803" decimals="0" contextRef="I2011Q2_DirectorMember_ConsultingAgreementMember" unitRef="USD"> 5000 </pcrx:RelatedPartyTransactionFeePayablePerMonth>
<pcrx:RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockNumberOfShares id="Tag804" decimals="INF" contextRef="D2011Q2_M06_DirectorMember_ConsultingAgreementMember" unitRef="Shares"> 10000 </pcrx:RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockNumberOfShares>
<pcrx:RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockExercisePrice id="Tag805" decimals="2" contextRef="D2011Q2_M06_DirectorMember_ConsultingAgreementMember" unitRef="USDPerShare"> 11.02 </pcrx:RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockExercisePrice>
<us-gaap:RelatedPartyTransactionAmountsOfTransaction id="Tag813" decimals="-5" contextRef="D2012_DirectorMember_ConsultingAgreementMember" unitRef="USD"> 200000 </us-gaap:RelatedPartyTransactionAmountsOfTransaction>
<pcrx:RelatedPartyTransactionFeePayablePerMonth id="Tag814" decimals="0" contextRef="I2010_MPMAssetManagementMember_ConsultingAgreementMember" unitRef="USD"> 26000 </pcrx:RelatedPartyTransactionFeePayablePerMonth>
<pcrx:RelatedPartyTransactionFeePayablePerMonth id="Tag815" decimals="0" contextRef="I2012_MPMAssetManagementMember_ConsultingAgreementMember" unitRef="USD"> 16000 </pcrx:RelatedPartyTransactionFeePayablePerMonth>
<pcrx:RelatedPartyTransactionPercentageOfConsultantBusinessTimeExchangedForFeePayablePerMonth id="Tag816" decimals="2" contextRef="I2010_MPMAssetManagementMember_ConsultingAgreementMember" unitRef="Pure"> 0.80 </pcrx:RelatedPartyTransactionPercentageOfConsultantBusinessTimeExchangedForFeePayablePerMonth>
<pcrx:RelatedPartyTransactionPercentageOfConsultantBusinessTimeExchangedForFeePayablePerMonth id="Tag817" decimals="2" contextRef="I2012_MPMAssetManagementMember_ConsultingAgreementMember" unitRef="Pure"> 0.50 </pcrx:RelatedPartyTransactionPercentageOfConsultantBusinessTimeExchangedForFeePayablePerMonth>
<pcrx:RelatedPartyTransactionPercentageOfConsultantBusinessTimeExchangedForFeePayablePerMonth id="Tag818" decimals="2" contextRef="I2013_MPMAssetManagementMember_ConsultingAgreementMember" unitRef="Pure"> 0.20 </pcrx:RelatedPartyTransactionPercentageOfConsultantBusinessTimeExchangedForFeePayablePerMonth>
<pcrx:RelatedPartyTransactionFeePayablePerMonth id="Tag819" decimals="0" contextRef="I2013_MPMAssetManagementMember_ConsultingAgreementMember" unitRef="USD"> 6000 </pcrx:RelatedPartyTransactionFeePayablePerMonth>
<pcrx:RelatedPartyTransactionFeePayablePerMonth id="Tag820" decimals="0" contextRef="I2011_MPMAssetManagementMember_ConsultingAgreementMember" unitRef="USD"> 26000 </pcrx:RelatedPartyTransactionFeePayablePerMonth>
<pcrx:RelatedPartyTransactionFeePayablePerMonth id="Tag821" decimals="0" contextRef="I2014_MPMAssetManagementMember_ConsultingAgreementMember" unitRef="USD"> 6000 </pcrx:RelatedPartyTransactionFeePayablePerMonth>
<pcrx:RelatedPartyTransactionPercentageOfConsultantBusinessTimeExchangedForFeePayablePerMonth id="Tag822" decimals="2" contextRef="I2011_MPMAssetManagementMember_ConsultingAgreementMember" unitRef="Pure"> 0.80 </pcrx:RelatedPartyTransactionPercentageOfConsultantBusinessTimeExchangedForFeePayablePerMonth>
<pcrx:RelatedPartyTransactionPercentageOfConsultantBusinessTimeExchangedForFeePayablePerMonth id="Tag823" decimals="2" contextRef="I2014_MPMAssetManagementMember_ConsultingAgreementMember" unitRef="Pure"> 0.20 </pcrx:RelatedPartyTransactionPercentageOfConsultantBusinessTimeExchangedForFeePayablePerMonth>
<us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearFour id="Tag825" decimals="-3" contextRef="I2012_CoreTechnologyMember" unitRef="USD"> 81000 </us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearFour>
<us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearFour id="Tag826" decimals="-3" contextRef="I2012" unitRef="USD"> 81000 </us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearFour>
<us-gaap:PaymentsToAcquireShortTermInvestments id="Tag827" decimals="-3" contextRef="D2011" unitRef="USD"> 52619000 </us-gaap:PaymentsToAcquireShortTermInvestments>
<us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized id="Tag828" decimals="INF" contextRef="D2012Q2_M0605_StockIncentivePlan2011Member" unitRef="Shares"> 2100000 </us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized>
<us-gaap:DebtInstrumentIncreaseAdditionalBorrowings id="Tag829" decimals="-5" contextRef="D2010Q4_M1124_TrancheAOfTermLoanMember" unitRef="USD"> 11300000 </us-gaap:DebtInstrumentIncreaseAdditionalBorrowings>
<pcrx:ContingentPaymentObligationEstablishedForSaleOfProductInConnectionWithAcquisition id="Tag830" decimals="-5" contextRef="I2012Q2_M0430" unitRef="USD"> 2000000 </pcrx:ContingentPaymentObligationEstablishedForSaleOfProductInConnectionWithAcquisition>
<us-gaap:ProceedsFromSaleOfShortTermInvestments id="Tag831" decimals="-3" contextRef="D2011" unitRef="USD"> 22649000 </us-gaap:ProceedsFromSaleOfShortTermInvestments>
<us-gaap:ProceedsFromDebtNetOfIssuanceCosts id="Tag832" decimals="-6" contextRef="D2013Q1_M01" unitRef="USD"> 120000000 </us-gaap:ProceedsFromDebtNetOfIssuanceCosts>
<us-gaap:StockIssuedDuringPeriodSharesNewIssues id="Tag833" decimals="INF" contextRef="D2011Q1_M0208" unitRef="Shares"> 6000000 </us-gaap:StockIssuedDuringPeriodSharesNewIssues>
<us-gaap:DebtConversionOriginalDebtAmount1 id="Tag834" decimals="-5" contextRef="D2011Q1_M0208_ConvertibleNotesPayableMember" unitRef="USD"> 51200000 </us-gaap:DebtConversionOriginalDebtAmount1>
<us-gaap:ProceedsFromIssuanceOfCommonStock id="Tag835" decimals="-5" contextRef="D2011Q1_M0208" unitRef="USD"> 37100000 </us-gaap:ProceedsFromIssuanceOfCommonStock>
<pcrx:StockIssuedDuringPeriodSharesFollowOnPublicOfferingIssues id="Tag836" decimals="INF" contextRef="D2011Q4_M11" unitRef="Shares"> 8050000 </pcrx:StockIssuedDuringPeriodSharesFollowOnPublicOfferingIssues>
<pcrx:StockIssuedDuringPeriodSharesFollowOnPublicOfferingIssues id="Tag837" decimals="INF" contextRef="D2012Q2_M04" unitRef="Shares"> 6900000 </pcrx:StockIssuedDuringPeriodSharesFollowOnPublicOfferingIssues>
<us-gaap:SharePrice id="Tag838" decimals="2" contextRef="I2012Q2_M0430" unitRef="USDPerShare"> 9.75 </us-gaap:SharePrice>
<us-gaap:ProceedsFromIssuanceOfCommonStock id="Tag839" decimals="-5" contextRef="D2012Q2_M04" unitRef="USD"> 62900000 </us-gaap:ProceedsFromIssuanceOfCommonStock>
<us-gaap:ProceedsFromIssuanceOfCommonStock id="Tag840" decimals="-5" contextRef="D2011Q4_M11" unitRef="USD"> 49000000 </us-gaap:ProceedsFromIssuanceOfCommonStock>
<pcrx:CommonStockSharesResultingFromCashlessExerciseOfWarrants id="Tag841" decimals="INF" contextRef="I2012Q4_M1005" unitRef="Shares"> 67279 </pcrx:CommonStockSharesResultingFromCashlessExerciseOfWarrants>
<us-gaap:EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate id="Tag842" decimals="4" contextRef="D2012" unitRef="Pure"> 0.3500 </us-gaap:EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate>
<us-gaap:EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate id="Tag843" decimals="4" contextRef="D2011" unitRef="Pure"> 0.3500 </us-gaap:EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate>
<us-gaap:EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate id="Tag844" decimals="4" contextRef="D2010" unitRef="Pure"> 0.3500 </us-gaap:EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate>
<us-gaap:EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes id="Tag845" decimals="4" contextRef="D2012" unitRef="Pure"> 0.0673 </us-gaap:EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes>
<us-gaap:EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes id="Tag846" decimals="4" contextRef="D2011" unitRef="Pure"> 0.0398 </us-gaap:EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes>
<us-gaap:EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes id="Tag847" decimals="4" contextRef="D2010" unitRef="Pure"> 0.0775 </us-gaap:EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes>
<us-gaap:EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance id="Tag848" decimals="4" contextRef="D2012" unitRef="Pure"> -0.3962 </us-gaap:EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance>
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<us-gaap:EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance id="Tag850" decimals="4" contextRef="D2010" unitRef="Pure"> -0.4477 </us-gaap:EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance>
<us-gaap:EffectiveIncomeTaxRateReconciliationTaxCredits id="Tag851" decimals="4" contextRef="D2012" unitRef="Pure"> 0.0000 </us-gaap:EffectiveIncomeTaxRateReconciliationTaxCredits>
<us-gaap:EffectiveIncomeTaxRateReconciliationTaxCredits id="Tag852" decimals="4" contextRef="D2011" unitRef="Pure"> -0.0013 </us-gaap:EffectiveIncomeTaxRateReconciliationTaxCredits>
<us-gaap:EffectiveIncomeTaxRateReconciliationTaxCredits id="Tag853" decimals="4" contextRef="D2010" unitRef="Pure"> -0.0018 </us-gaap:EffectiveIncomeTaxRateReconciliationTaxCredits>
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<us-gaap:EffectiveIncomeTaxRateContinuingOperations id="Tag859" decimals="4" contextRef="D2010" unitRef="Pure"> 0.0000 </us-gaap:EffectiveIncomeTaxRateContinuingOperations>
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<pcrx:RelatedPartyTransactionFeePayablePerMonth decimals="0" contextRef="I2012Q3_M0831_ConsultingAgreementMember_DirectorMember" unitRef="USD"> 15000 </pcrx:RelatedPartyTransactionFeePayablePerMonth>
<pcrx:RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockNumberOfShares decimals="INF" contextRef="D2012Q3_M08_ConsultingAgreementMember_DirectorMember" unitRef="Shares"> 70000 </pcrx:RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockNumberOfShares>
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<pcrx:RelatedPartyTransactionFeePayablePerMonth decimals="0" contextRef="I2012Q2_M0430_ConsultingAgreementMember_DirectorMember" unitRef="USD"> 10000 </pcrx:RelatedPartyTransactionFeePayablePerMonth>
<pcrx:RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockNumberOfShares decimals="INF" contextRef="D2012Q2_M04_ConsultingAgreementMember_DirectorMember" unitRef="Shares"> 20000 </pcrx:RelatedPartyTransactionOptionToPurchaseSharesOfCommonStockNumberOfShares>
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<us-gaap:RelatedPartyTransactionAmountsOfTransaction decimals="-5" contextRef="D2011_ConsultingAgreementMember_MaximumMember_DirectorMember" unitRef="USD"> 100000 </us-gaap:RelatedPartyTransactionAmountsOfTransaction>
<us-gaap:DueToRelatedPartiesCurrentAndNoncurrent decimals="-5" contextRef="I2012_MPMAssetManagementMember" unitRef="USD"> 100000 </us-gaap:DueToRelatedPartiesCurrentAndNoncurrent>
<pcrx:RelatedPartyTransactionEligibleBonusUponMeetingTargets decimals="-5" contextRef="D2012Q3_M08_ConsultingAgreementMember_MaximumMember_DirectorMember" unitRef="USD"> 200000 </pcrx:RelatedPartyTransactionEligibleBonusUponMeetingTargets>
<pcrx:NumberOfMajorCustomers decimals="INF" contextRef="D2011" unitRef="Item"> 2 </pcrx:NumberOfMajorCustomers>
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</xbrli:xbrl>


2 Subsequent Filings that Reference this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

12/13/13  SEC                               UPLOAD9/20/17    1:34K  Pacira BioSciences, Inc.
12/02/13  SEC                               UPLOAD9/20/17    1:153K Pacira BioSciences, Inc.
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