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Opko Health, Inc. – ‘10-Q’ for 9/30/12 – ‘EX-101.INS’

On:  Friday, 11/9/12, at 4:31pm ET   ·   For:  9/30/12   ·   Accession #:  1193125-12-463415   ·   File #:  1-33528

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  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

11/09/12  Opko Health, Inc.                 10-Q        9/30/12   60:6.7M                                   Donnelley … Solutions/FA

Quarterly Report   —   Form 10-Q   —   Sect. 13 / 15(d) – SEA’34
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-Q        Quarterly Report                                    HTML    456K 
 2: EX-2.8      Plan of Acquisition, Reorganization, Arrangement,   HTML    287K 
                Liquidation or Succession                                        
 3: EX-31.1     Certification -- §302 - SOA'02                      HTML     25K 
 4: EX-31.2     Certification -- §302 - SOA'02                      HTML     25K 
 5: EX-32.1     Certification -- §906 - SOA'02                      HTML     19K 
 6: EX-32.2     Certification -- §906 - SOA'02                      HTML     18K 
40: R1          Document and Entity Information                     HTML     38K 
30: R2          Condensed Consolidated Balance Sheets               HTML    134K 
38: R3          Condensed Consolidated Balance Sheets               HTML     60K 
                (Parenthetical) (Unaudited)                                      
42: R4          Condensed Consolidated Statements of Operations     HTML    116K 
                (Unaudited)                                                      
55: R5          Condensed Consolidated Statements of Comprehensive  HTML     39K 
                Loss (Unaudited)                                                 
32: R6          Condensed Consolidated Statements of Cash Flows     HTML    168K 
                (Unaudited)                                                      
37: R7          Business and Organization                           HTML     29K 
27: R8          Summary of Significant Accounting Policies          HTML     41K 
18: R9          Loss Per Share                                      HTML     24K 
56: R10         Composition of Certain Financial Statement          HTML     55K 
                Captions                                                         
44: R11         Acquisitions, Investments, and Licenses             HTML     98K 
43: R12         Discontinued Operations                             HTML     44K 
48: R13         Fair Value Measurements                             HTML     86K 
49: R14         Derivative Contracts                                HTML     43K 
47: R15         Related Party Transactions                          HTML     40K 
50: R16         Commitments and Contingencies                       HTML     26K 
39: R17         Segments                                            HTML     61K 
41: R18         Subsequent Events                                   HTML     23K 
46: R19         Summary of Significant Accounting Policies          HTML    100K 
                (Policies)                                                       
60: R20         Composition of Certain Financial Statement          HTML     54K 
                Captions (Tables)                                                
52: R21         Acquisitions, Investments, and Licenses (Tables)    HTML     75K 
34: R22         Discontinued Operations (Tables)                    HTML     39K 
45: R23         Fair Value Measurements (Tables)                    HTML     85K 
36: R24         Derivative Contracts (Tables)                       HTML     32K 
15: R25         Segments (Tables)                                   HTML     52K 
53: R26         Summary of Significant Accounting Policies          HTML     40K 
                (Details)                                                        
57: R27         Loss Per Share (Details)                            HTML     28K 
23: R28         Composition of Certain Financial Statement          HTML    115K 
                Captions (Details)                                               
22: R29         Acquisitions, Investments, and Licenses (Details)   HTML     70K 
25: R30         Acquisitions, Investments, and Licenses (Details    HTML     49K 
                1)                                                               
26: R31         Acquisitions, Investments, and Licenses (Details    HTML     64K 
                2)                                                               
28: R32         Acquisitions, Investments, and Licenses (Details    HTML    286K 
                Textual)                                                         
14: R33         Discontinued Operations (Details)                   HTML     34K 
51: R34         Discontinued Operations (Details 1)                 HTML     34K 
33: R35         Discontinued Operations (Details Textual)           HTML     23K 
35: R36         Fair Value Measurements (Details)                   HTML     41K 
17: R37         Fair Value Measurements (Details 1)                 HTML     73K 
59: R38         Fair Value Measurements (Details 2)                 HTML     41K 
13: R39         Fair Value Measurements (Details Textual)           HTML     38K 
29: R40         Derivative Contracts (Details)                      HTML     33K 
54: R41         Related Party Transactions (Details)                HTML    239K 
16: R42         Commitments and Contingencies (Details)             HTML     33K 
21: R43         Segments (Details)                                  HTML     42K 
24: R44         Segments (Details Textual)                          HTML     30K 
31: R45         Subsequent Events (Details)                         HTML     34K 
58: XML         IDEA XML File -- Filing Summary                      XML     88K 
20: EXCEL       IDEA Workbook of Financial Reports (.xls)            XLS   1.03M 
 7: EX-101.INS  XBRL Instance -- opk-20120930                        XML   1.31M 
 9: EX-101.CAL  XBRL Calculations -- opk-20120930_cal                XML    186K 
10: EX-101.DEF  XBRL Definitions -- opk-20120930_def                 XML    592K 
11: EX-101.LAB  XBRL Labels -- opk-20120930_lab                      XML   1.25M 
12: EX-101.PRE  XBRL Presentations -- opk-20120930_pre               XML    848K 
 8: EX-101.SCH  XBRL Schema -- opk-20120930                          XSD    187K 
19: ZIP         XBRL Zipped Folder -- 0001193125-12-463415-xbrl      Zip    146K

‘EX-101.INS’   —   XBRL Instance — opk-20120930

This Exhibit is an XBRL XML File.

                                                                                                                                                                                
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<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Note 1 - us-gaap:OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock--> <!-- xbrl,ns --> <!-- xbrl,nx --> <font style="font-family:times new roman" size="2"></font> <p style="margin-top:6px;margin-bottom:0px"><font style="font-family:times new roman" size="2"><b>NOTE 1 BUSINESS AND ORGANIZATION </b></font></p> <p style="margin-top:6px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">We are a multi-national pharmaceutical and diagnostics company that seeks to establish industry-leading positions in large and rapidly growing medical markets by leveraging our discovery, development and commercialization expertise and our novel and proprietary technologies. We are developing a range of solutions to diagnose, treat and prevent various conditions, including molecular diagnostics tests, laboratory developed tests, point-of-care tests, and proprietary pharmaceuticals and vaccines. We plan to commercialize these solutions on a global basis in large and high growth markets, including emerging markets. We own established pharmaceutical platforms in Spain, Chile and Mexico, which are generating revenue and which we expect to generate positive cash flow and facilitate future market entry for our products currently in development. We also operate a specialty active pharmaceutical ingredients (“APIs”) manufacturer in Israel, which is currently generating revenue and positive cash flow, and which we expect to play a valuable role in the development of our pipeline of peptoids and other molecules for our proprietary molecular diagnostic and therapeutic products. We continue to actively explore opportunities to acquire complementary pharmaceuticals, compounds, technologies, and businesses. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">We are incorporated in Delaware and our principal executive offices are located in leased offices in Miami, Florida. We lease office and lab space in Jupiter and Miramar, Florida, which is where our molecular diagnostics research and development and oligonucleotide research and development operations are based, respectively. We lease office, manufacturing, research and development and warehouse space in Woburn, Massachusetts for our point-of-care diagnostics business, and in Nesher, Israel for our API business. Our Chilean operations are located in leased offices and a leased warehouse facility in Santiago, Chile. Our Mexican operations are based in owned offices, manufacturing facilities and in a leased warehouse facility in Guadalajara, Mexico. Our Spanish operations are based in owned offices in Barcelona, Spain and in an owned manufacturing facility in Banyoles, Spain. </font></p>
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<us-gaap:SignificantAccountingPoliciesTextBlock contextRef="Jan-01-2012_Sep-30-2012">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Note 2 - us-gaap:SignificantAccountingPoliciesTextBlock--> <p style="margin-top:18px;margin-bottom:0px"><font style="font-family:times new roman" size="2"><b>NOTE 2 SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES </b></font></p> <p style="font-size:6px;margin-top:0px;margin-bottom:0px"> </p> <p style="margin-top:6px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Basis of presentation. </i>The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States and with the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, they do not include all information and notes required by accounting principles generally accepted in the United States for complete financial statements. In the opinion of management, all adjustments (consisting of only normal recurring adjustments) considered necessary to present fairly the Company’s results of operations, financial position and cash flows have been made. The results of operations for the three and nine months ended September 30, 2012 and cash flows for the nine months ended September 30, 2012, are not necessarily indicative of the results of operations and cash flows that may be reported for the remainder of 2012 or for future periods. The unaudited condensed consolidated financial statements should be read in conjunction with the Consolidated Financial Statements and the Notes to Consolidated Financial Statements included in our Annual Report on Form 10-K for the year ended December 31, 2011. </font></p> <p style="font-size:12px;margin-top:0px;margin-bottom:0px"> </p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Reclassifications. </i>As further discussed in Note 6, the results of operations and the assets and the liabilities related to the instrumentation business have been accounted for as discontinued operations. Accordingly, the results of the operations related to the instrumentation business from prior periods have been reclassified to discontinued operations. </font></p> <p style="font-size:12px;margin-top:0px;margin-bottom:0px"> </p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Principles of consolidation</i>. The accompanying unaudited condensed consolidated financial statements include the accounts of OPKO Health, Inc. and our wholly-owned subsidiaries. All significant intercompany accounts and transactions are eliminated in consolidation. </font></p> <p style="font-size:12px;margin-top:0px;margin-bottom:0px"> </p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Use of estimates</i>. The preparation of financial statements in conformity with accounting principles generally accepted in the United States of America requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates. </font></p> <p style="font-size:12px;margin-top:0px;margin-bottom:0px"> </p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Cash and cash equivalents. </i>Cash and cash equivalents include short-term, interest-bearing instruments with original maturities of 90 days or less at the date of purchase. We also consider all highly liquid investments with original maturities at the date of purchase of 90 days or less as cash equivalents. These investments include money markets, bank deposits, certificates of deposit and U.S. treasury securities. </font></p> <p style="font-size:1px;margin-top:12px;margin-bottom:0px"> </p> <p> </p> <p style="margin-top:0px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Marketable securities. </i>Investments with original maturities of greater than 90 days and remaining maturities of less than one year are classified as marketable securities. Marketable securities include U.S. treasury securities and certificates of deposit. Unrealized gains and losses on investments are included in Accumulated other comprehensive income (“OCI”) as a separate component of shareholders’ equity. Realized gains and losses, dividends, interest income, and declines in value judged to be other-than-temporary credit losses are included in Other income and (expense), net. Amortization of any premium or discount arising at purchase is included in Interest income. </font></p> <p style="font-size:12px;margin-top:0px;margin-bottom:0px"> </p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Inventories. </i>Inventories are valued at the lower of cost or market (net realizable value). Cost is determined by the first-in, first-out method. We consider such factors as the amount of inventory on hand, estimated time required to sell such inventories, remaining shelf-life, and current market conditions to determine whether inventories are stated at the lower of cost or market. </font></p> <p style="font-size:12px;margin-top:0px;margin-bottom:0px"> </p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Revenue recognition. </i>Generally, we recognize revenue from product sales when goods are shipped and title and risk of loss transfer to our customers. Our estimates for sales returns and allowances are based upon the historical patterns of products returned and allowances taken, matched against the sales from which they originated, and management’s evaluation of specific factors that may increase the risk of product returns. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">Other revenue includes revenue related to upfront license payments, license fees and milestone payments received through our license, collaboration and commercialization agreements. We analyze our multiple-element arrangements to determine whether the elements can be separated and accounted for individually as separate units of accounting. Other revenue for the three and nine months ended September 30, 2012, includes $0.3 million and $0.7 million, respectively, of revenue related to our consulting agreement with Neovasc, Inc. and to revenue related to molecular diagnostics collaboration agreements. Refer to Note 5. We recognize this revenue on a straight-line basis over the contractual term of the agreements. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">Non-refundable license fees for the out-license of our technology are recognized depending on the provisions of each agreement. We recognize non-refundable upfront license payments as revenue upon receipt if the license has standalone value and the fair value of our undelivered obligations, if any, can be determined. If the license is considered to have standalone value but the fair value of any of the undelivered items cannot be determined, the license payments are recognized as revenue over the period of our performance for such undelivered items or services. License fees with ongoing involvement or performance obligations are recorded as deferred revenue as Accrued expenses or Other long-term liabilities, when received and generally are recognized ratably over the period of such performance obligation only after both the license period has commenced and we have delivered the technology. The assessment of our obligations and related performance periods requires significant management judgment. If an agreement contains research and development obligations, the relevant time period for the research and development phase is based on management estimates and could vary depending on the outcome of clinical trials and the regulatory approval process. Such changes could materially impact the revenue recognized, and as a result, management reviews the estimates related to the relevant time period of research and development on a quarterly basis. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">Revenue from milestone payments related to arrangements under which we have continuing performance obligations are recognized as Other revenue upon achievement of the milestone only if all of the following conditions are met: the milestone payments are non-refundable; there was substantive uncertainty at the date of entering into the arrangement that the milestone would be achieved; the milestone is commensurate with either the vendor’s performance to achieve the milestone or the enhancement of the value of the delivered item by the vendor; the milestone relates solely to past performance; and the amount of the milestone is reasonable in relation to the effort expended or the risk associated with the achievement of the milestone. If any of these conditions are not met, the milestone payments are not considered to be substantive and are, therefore, deferred and recognized as Other revenue over the term of the arrangement as we complete our performance obligations. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">Total deferred revenue recorded as Accrued expenses and Other long-term liabilities at September 30, 2012 and December 31, 2011, was $1.4 million and $0.9 million, respectively. </font></p> <p style="font-size:12px;margin-top:0px;margin-bottom:0px"> </p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Derivative financial instruments. </i>We record derivative financial instruments on our balance sheet at their fair value and the changes in the fair value are recognized in Other income (expense), net, when they occur, the only exception being derivatives that qualify as hedges. For the derivative instrument to qualify as a hedge, we are required to meet strict hedge effectiveness and contemporaneous documentation requirements at the initiation of the hedge and assess the hedge effectiveness on an ongoing basis over the life of the hedge. At September 30, 2012 and December 31, 2011, our forward contracts for inventory purchases did not meet the documentation requirements to be designated as hedges. Accordingly, we recognize all changes in fair values of the forward contracts in Other income (expense), net. Refer to Note 8. Changes in fair value of our common stock option and common stock warrant holdings of our available for sale investments are recognized in either Other income (expense), net, or Other comprehensive loss, net. Refer to Note 7. </font></p> <p style="font-size:12px;margin-top:0px;margin-bottom:0px"> </p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Product warranties</i>. Product warranty expense is recorded concurrently with the recording of revenue for product sales. The costs of warranties are accounted for as a component of cost of sales. We estimate warranty costs based on our estimated historical experience and adjust for any known product reliability issues. </font></p> <p style="font-size:12px;margin-top:0px;margin-bottom:0px"> </p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Allowance for doubtful accounts</i>. We analyze accounts receivable and historical bad debt levels, customer credit worthiness and current economic trends when evaluating the adequacy of the allowance for doubtful accounts using the specific identification method. Our reported net loss is directly affected by our estimate of the collectability of accounts receivable. The amount of allowance for doubtful accounts was $0.3 million and $0.4 million at September 30, 2012 and December 31, 2011, respectively. </font></p> <p style="font-size:12px;margin-top:0px;margin-bottom:0px"> </p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Segment reporting</i>. Our chief operating decision-maker (“CODM”) is comprised of our executive management team with the oversight of our Board of Directors. Our CODM reviews our operating results and operating plans and makes resource allocation decisions on a Company-wide or aggregate basis. We currently manage our operations in one reportable segment, pharmaceuticals. The pharmaceutical segment consists of two operating segments, our (i) pharmaceutical research and development segment which is focused on the research and development of pharmaceutical products, diagnostic tests and vaccines, and (ii) the pharmaceutical operations we acquired in Chile, Mexico, Israel and Spain through the acquisition of OPKO Chile S.A. (“OPKO Chile”), Exakta-OPKO S.A. de C.V (“Exakta-OPKO”), FineTech Pharmaceuticals Ltd. (“FineTech”) and Farmadiet Group Holding, S.L. (“Farmadiet”), respectively. We evaluate the performance of each operating segment based on operating profit or loss. There is no inter-segment allocation of interest expense and income taxes. </font></p> <p style="font-size:12px;margin-top:0px;margin-bottom:0px"> </p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Equity-based compensation. </i>We measure the cost of employee services received in exchange for an award of equity instruments based on the grant-date fair value of the award. That cost is recognized in the statement of operations over the period during which an employee is required to provide service in exchange for the award. We record excess tax benefits, realized from the exercise of stock options as a financing cash inflow rather than as a reduction of taxes paid in cash flow from operations. Equity-based compensation arrangements to non-employees are recorded at their fair value on the measurement date. The measurement of equity-based compensation is subject to periodic adjustment as the underlying equity instruments vest. During the three months ended September 30, 2012 and 2011, we recorded $1.1 million and $1.8 million, respectively, of equity-based compensation expense. For the nine months ended September 30, 2012 and 2011, we recorded $3.3 million and $5.4 million, respectively, of equity-based compensation expense. </font></p> <p style="font-size:12px;margin-top:0px;margin-bottom:0px"> </p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Recent accounting pronouncements. </i>On January 1, 2012, we adopted an amendment issued by the Financial Accounting Standards Board (“FASB”) to the accounting standards related to fair value measurements and disclosure requirements. This amendment revises the existing guidance on the use and application of fair value measurements and maintains a definition of fair value that is based on the notion of exit price. The adoption of this amendment did not have a material impact on our condensed consolidated financial statements. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">On January 1, 2012, we adopted amendments issued by the FASB to the accounting standards related to the presentation of comprehensive income. These amendments revise the manner in which entities present comprehensive income in their financial statements and remove the option to present items of other comprehensive income in the statement of changes in stockholders’ equity. These amendments require an entity to report components of comprehensive income in either (1) a continuous statement of comprehensive income, or (2) two separate but consecutive statements of net income and other comprehensive income. We modified our condensed consolidated financial statements presentation using the latter alternative. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">On January 1, 2012, we adopted revised guidance issued by the FASB related to the testing of goodwill for impairment. Under the revised guidance, an entity has the option to perform a qualitative assessment of whether it is more-likely-than-not that a reporting unit’s fair value is less than its carrying value prior to performing the two-step quantitative goodwill impairment test. If, based on the qualitative factors, an entity determines that the fair value of the reporting unit is greater than its carrying amount, then the entity would not be required to perform the two-step quantitative impairment test for that reporting unit. However, if the qualitative assessment indicates that it is not more-likely-than-not that the reporting unit’s fair value exceeds its carrying value, then the quantitative assessment must be performed. An entity is permitted to perform the qualitative assessment on none, some or all of its reporting units and may also elect to bypass the qualitative assessment and begin with the quantitative assessment of goodwill impairment. This amendment did not have a material impact on our condensed consolidated financial statements. </font></p>
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<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Note 3 - us-gaap:EarningsPerShareTextBlock--> <p style="margin-top:18px;margin-bottom:0px"><font style="font-family:times new roman" size="2"><b>NOTE 3 LOSS PER SHARE </b></font></p> <p style="margin-top:6px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">Basic loss per share is computed by dividing our net loss by the weighted average number of shares outstanding during the period. Diluted loss per share is computed by dividing our net loss by the weighted average number of shares outstanding and the impact of all dilutive potential common shares, primarily stock options. The dilutive impact of stock options and warrants is determined by applying the “treasury stock” method. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">A total of 26,022,072 and 26,263,152 potential common shares have been excluded from the calculation of net loss per share for the three months ended September 30, 2012 and 2011, respectively, because their inclusion would be anti-dilutive. In addition, a total of 26,836,546 and 27,375,394 potential common shares have been excluded from the calculation of net loss per share for the nine months ended September 30, 2012 and 2011, respectively, because their inclusion would be anti-dilutive. As of September 30, 2012, the holders of our Series D Preferred Stock could convert their preferred shares into approximately 12,110,750 shares of our Common Stock. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"> During the nine months ended September 30, 2012, we issued 748,783 shares of our Common Stock as a result of Common Stock options and Common Stock warrants exercised. </font></p> <p style="font-size:1px;margin-top:18px;margin-bottom:0px"> </p>
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<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Note 4 - us-gaap:SupplementalBalanceSheetDisclosuresTextBlock--> <p style="margin-top:0px;margin-bottom:0px"><font style="font-family:times new roman" size="2"><b>NOTE 4 COMPOSITION OF CERTAIN FINANCIAL STATEMENT CAPTIONS </b></font></p> <p style="font-size:12px;margin-top:0px;margin-bottom:0px"> </p> <table cellspacing="0" cellpadding="0" width="100%" border="0" style="border-collapse:collapse; text-align: left" align="center"> <!-- Begin Table Head --> <tr> <td width="82%"> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td valign="bottom" nowrap="nowrap"> <p style="border-bottom:1px solid #000000;width:45pt"><font style="font-family:times new roman" size="1">(In thousands)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">September 30,<br />2012<br />(unaudited)</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">December 31,<br />2011<br />(audited)</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <!-- End Table Head --> <!-- Begin Table Body --> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Accounts receivable, net</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Accounts receivable</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">19,490</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">12,984</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Less: allowance for doubtful accounts</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(348</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(440</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr> <td valign="top"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">19,142</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">12,544</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Inventories, net</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Finished products</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">17,750</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">11,100</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Work-in process</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">633</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">277</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Raw materials</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">4,513</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,287</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Less: reserve for obsolescence</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(1,408</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(325</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr> <td valign="top"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">21,488</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">13,339</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Intangible assets, net</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Customer relationships</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">19,232</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">18,386</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">In-process research and development</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">11,504</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">10,000</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Technology</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">50,211</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">47,100</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Product registrations</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">9,638</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">3,895</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Tradename</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,921</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">827</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Covenants not to compete</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,758</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,560</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Other</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">297</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">297</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Less: accumulated amortization</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(11,975</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(5,335</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr> <td valign="top"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">82,586</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">76,730</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Accrued expenses</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Income taxes payable</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">649</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">484</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Deferred revenue</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">955</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">530</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Clinical trials</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">58</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">7</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Professional fees</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">817</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">632</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Employee benefits</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,910</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">907</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Deferred acquisition payments, net of discount</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">5,983</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Contingent consideration</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">7,992</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Other</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">3,430</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,396</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr> <td valign="top"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">21,794</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">4,956</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Other long-term liabilities</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Contingent consideration</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">13,909</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">18,002</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Deferred acquisition payments, net of discount</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">3,769</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Deferred tax liabilities</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">10,845</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">6,863</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-top:0px;margin-bottom:1px; margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Long-term debt</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">3,954</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Other including deferred revenue</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">453</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">578</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">32,930</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">25,443</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <!-- End Table Body --> </table> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">The change in value of the intangible assets includes the acquisitions of Farmadiet and ALS Distribuidora Limitada (“ALS”) (Refer to Note 5) and the foreign currency fluctuation between the Chilean and Mexican pesos against the US dollar at September 30, 2012 and December 31, 2011. </font></p> <p style="font-size:1px;margin-top:18px;margin-bottom:0px"> </p>
</us-gaap:SupplementalBalanceSheetDisclosuresTextBlock>
<!-- End Block Tagged Note --> <!-- Begin Block Tagged Note -->
<us-gaap:BusinessCombinationDisclosureTextBlock contextRef="Jan-01-2012_Sep-30-2012">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Note 5 - us-gaap:BusinessCombinationDisclosureTextBlock--> <p style="margin-top:0px;margin-bottom:0px"><font style="font-family:times new roman" size="2"><b>NOTE 5 ACQUISITIONS, INVESTMENTS, AND LICENSES </b></font></p> <p style="margin-top:6px;margin-bottom:0px; margin-left:4%"><font style="font-family:times new roman" size="2"><i>Farmadiet acquisition </i></font></p> <p style="margin-top:6px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"> In August 2012, we entered into a stock purchase agreement pursuant to which we acquired all of the outstanding stock of Farmadiet, a Spanish company engaged in the development, manufacture, marketing, and sale of pharmaceutical, nutraceutical, and veterinary products in Europe (the “Transaction”). </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">In connection with the Transaction, we agreed to pay an aggregate purchase price of €13.5 million (approximately $16.0 million), of which (i) 50% ($8.4 million) was paid in cash at closing, and (ii) 50% (the “Deferred Payments”) will be paid, at our option, in cash or shares of our Common Stock as follows: (x) 25% to be paid on the first anniversary of the closing date; and (y) 25% to be paid 18 months after the closing date. On the date of acquisition, we recorded the €6.8 million Deferred Payments at $7.8 million, net of a discount of $0.6 million. The discount will be amortized as interest expense through the respective payment dates. The Deferred Payments are required to be paid in Euro and as such, the final U.S. dollar amount to be paid will be based on the exchange rate at the time the Deferred Payments are made. In the event we elect to pay the Deferred Payments in shares of our Common Stock, the number of shares issuable shall be calculated using the average closing sales price per share of our Common Stock as reported on the New York Stock Exchange (“NYSE”) for the ten trading days immediately preceding the applicable payment date. We have the right to hold back up to $3.4 million from the Deferred Payment to satisfy indemnity claims. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">In connection with the Transaction, we also entered into two ancillary transactions (the “Ancillary Transactions”). In exchange for a forty percent interest held by one of the sellers in one of Farmadiet’s subsidiaries, we agreed to issue up to an aggregate of 250,000 shares of our Common Stock, of which (a) 125,000 shares were issued on the closing date, and (b) 125,000 will be issued upon achieving certain milestones. In addition, we acquired an interest held by an affiliate of Farmadiet in a product in development in exchange for which we agreed to pay up to an aggregate of €1.0 million ($1.1 million) payable at our option in cash or shares of our Common Stock, of which (a) 25% ($0.3 million) was paid at closing through delivery of 70,421 shares of our Common Stock, and 75% ($0.8 million) will be paid in cash or shares of our Common Stock upon achieving certain milestones. The final U.S. dollar amount to be paid will be based on the exchange rate at the time the milestones are achieved. The number of shares of our Common Stock issued is determined based on the average closing sales price for our Common Stock on the NYSE for the ten trading days preceding the required payment date. </font></p> <p style="margin-top:18px;margin-bottom:0px; margin-left:4%"><font style="font-family:times new roman" size="2"><i>ALS acquisition </i></font></p> <p style="margin-top:6px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"> In April 2012, we completed the acquisition of ALS, a privately-held Chilean pharmaceutical company, pursuant to a stock purchase agreement entered into in January 2012. In connection with the transaction, we agreed to pay up to a total of $4.0 million in cash to the sellers. Pursuant to the purchase agreement, we paid (i) $2.4 million in cash at the closing, less certain liabilities, and (ii) $0.8 million in cash at the closing into a separate escrow account to satisfy possible indemnity claims. We agreed to pay an additional $0.8 million, the remainder of the $4.0 million purchase price, upon the legal registration in the name of ALS of certain trademarks and product registrations previously held by Arama Laboratorios y Compańía Limitada. </font></p> <p style="font-size:1px;margin-top:12px;margin-bottom:0px"> </p> <p style="margin-top:0px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">The following table summarizes the preliminary fair value allocation of the net assets acquired and liabilities assumed in the acquisitions of Farmadiet and ALS at the dates of acquisition, which are subject to change while contingencies that existed on the acquisition dates are resolved: </font></p> <p style="font-size:12px;margin-top:0px;margin-bottom:0px"> </p> <table cellspacing="0" cellpadding="0" width="68%" border="0" style="border-collapse:collapse; text-align: left" align="center"> <!-- Begin Table Head --> <tr> <td width="88%"> </td> <td valign="bottom" width="6%"> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td valign="bottom" nowrap="nowrap"> <p style="border-bottom:1px solid #000000;width:45pt"><font style="font-family:times new roman" size="1">(In thousands)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td colspan="2" valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <!-- End Table Head --> <!-- Begin Table Body --> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Current assets (includes cash of $230)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">9,134</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Intangible assets:</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Customer relationships</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">436</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Technology</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">5,437</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">In-process research and development</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,459</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Product registrations</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">5,230</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Covenants not to compete</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">187</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Tradename</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,029</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:5.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total intangible assets</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">13,778</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Goodwill</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">8,520</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Plant and equipment</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">7,229</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Other assets</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">611</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Accounts payable and accrued expenses</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(3,667</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Deferred tax liability</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(3,169</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Deferred payment</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(7,755</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Debt assumed</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(7,829</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Contingent consideration</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(1,197</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total purchase price</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">15,655</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <!-- End Table Body --> </table> <p style="margin-top:18px;margin-bottom:0px; margin-left:4%"><font style="font-family:times new roman" size="2"><i>FineTech acquisition </i></font></p> <p style="margin-top:6px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"> In December 2011, we purchased all of the issued and outstanding shares of FineTech, a privately-held Israeli pharmaceutical company focused on the development and production of APIs. At closing, we delivered to the seller $27.7 million, of which $10.0 million was paid in cash and $17.7 million was paid in shares of our Common Stock. The shares delivered at closing were valued at $17.7 million based on the closing sales price per share of our Common Stock as reported by the NYSE on the actual closing date of the acquisition, or $4.90 per share. The number of shares issued was based on the average closing sales price per share of our Common Stock as reported on the NYSE for the ten trading days immediately preceding the execution of the purchase agreement, or $4.84 per share. Upon finalization of the closing financial statements of FineTech, we recorded an additional $0.5 million purchase price adjustment related to a working capital surplus, as defined in the purchase agreement, which was paid to the seller in February 2012. In addition, the purchase agreement provides for the payment of additional cash consideration subject to the achievement of certain sales milestones. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">The following table summarizes the preliminary fair value allocation of the net assets acquired and liabilities assumed in the acquisition of FineTech at the date of acquisition, which are subject to change while contingencies that existed on the acquisition date are resolved: </font></p> <p style="font-size:12px;margin-top:0px;margin-bottom:0px"> </p> <table cellspacing="0" cellpadding="0" width="68%" border="0" style="border-collapse:collapse; text-align: left" align="center"> <!-- Begin Table Head --> <tr> <td width="88%"> </td> <td valign="bottom" width="6%"> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td valign="bottom" nowrap="nowrap"> <p style="border-bottom:1px solid #000000;width:45pt"><font style="font-family:times new roman" size="1">(In thousands)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td colspan="2" valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <!-- End Table Head --> <!-- Begin Table Body --> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Current assets (including cash of $2,000)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">3,358</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Intangible assets:</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Customer relationships</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">14,200</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Technology</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,700</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Covenants not to compete</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,500</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Tradename</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">400</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:5.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total intangible assets</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">18,800</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Goodwill</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">11,623</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Plant and equipment</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,358</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Other assets</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,154</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Accounts payable and accrued expenses</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(910</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Deferred tax liability</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(2,457</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Contingent consideration</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(4,747</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total purchase price</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">28,179</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <!-- End Table Body --> </table> <p style="margin-top:0px;margin-bottom:0px; margin-left:4%"><font style="font-family:times new roman" size="2"><i>Claros Diagnostics acquisition </i></font></p> <p style="margin-top:6px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">In October 2011, we acquired Claros Diagnostics, Inc. (“OPKO Diagnostics”) pursuant to an agreement and plan of merger. We paid $10.0 million in cash, subject to certain set-offs and deductions, and $22.5 million in shares of our Common Stock, based on the closing sales price per share of our Common Stock as reported by the NYSE on the closing date of the merger, or $5.04 per share. The number of shares issued was based on the average closing sales price per share of our Common Stock as reported by the NYSE for the ten trading days immediately preceding the date of the merger, or $4.45 per share. Pursuant to the merger agreement, $5.0 million of the stock consideration was held in a separate escrow account until October 2012 to secure the indemnification obligations of Claros Diagnostics under the Claros Diagnostics, Inc. merger agreement. In December 2011, we made a $0.2 million claim against the escrow for certain undisclosed liabilities. In addition, the merger agreement provides for the payment of up to an additional $19.1 million in shares of our Common Stock upon and subject to the achievement of certain milestones. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">The following table summarizes the preliminary fair value allocation of the net assets acquired and liabilities assumed in the acquisition of OPKO Diagnostics at the date of acquisition, which are subject to change while contingencies that existed on the acquisition date are resolved: </font></p> <p style="font-size:12px;margin-top:0px;margin-bottom:0px"> </p> <table cellspacing="0" cellpadding="0" width="68%" border="0" style="border-collapse:collapse; text-align: left" align="center"> <!-- Begin Table Head --> <tr> <td width="87%"> </td> <td valign="bottom" width="7%"> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td valign="bottom" nowrap="nowrap"> <p style="border-bottom:1px solid #000000;width:45pt"><font style="font-family:times new roman" size="1">(In thousands)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td colspan="2" valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <!-- End Table Head --> <!-- Begin Table Body --> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Current assets (including cash of $351)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">378</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Technology</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">44,400</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Goodwill</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">17,977</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Equipment</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">333</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Other assets</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">18</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Accounts payable and accrued expenses</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(655</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Deferred tax liability</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(17,254</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Contingent consideration</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(12,745</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total purchase price</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">32,452</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <!-- End Table Body --> </table> <p style="margin-top:18px;margin-bottom:0px; margin-left:4%"><font style="font-family:times new roman" size="2"><i>Investments </i></font></p> <p style="margin-top:6px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"> In February 2012, we made a $1.0 million investment in ChromaDex Corporation (“ChromaDex”), a publicly-traded company and leading provider of proprietary ingredients and products for the dietary supplement, nutraceutical, food and beverage, functional food, pharmaceutical and cosmetic markets, in exchange for 1,333,333 shares of ChromaDex common stock, at $0.75 per share. In connection with our investment, we also entered into a license, supply and distribution agreement with ChromaDex pursuant to which we obtained exclusive distribution rights to certain of its products in Latin America. Our investment was part of a $3.7 million private placement by ChromaDex. Other investors participating in the private financing included certain related parties. Refer to Note 9. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">We have determined that our ownership, along with that of our related parties, do not provide us with significant influence over the operations of ChromaDex and as a result, we account for ChromaDex as an investment, available for sale, and we record changes in the fair value of ChromaDex as an unrealized gain or loss in Other comprehensive loss each reporting period. Refer to Note 7. The closing price of ChromaDex was $0.78 per share on September 30, 2012. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">In February 2012, we purchased from Biozone Pharmaceuticals, Inc., a publicly traded company that specializes in drug development, manufacturing, and marketing (“BZNE”), $1.7 million of 10% secured convertible promissory notes (the “BZNE Notes”), convertible into BZNE common stock at a price equal to $0.20 per common share, which BZNE Notes are due and payable on February 24, 2014 and ten year warrants (the “BZNE Warrants”) to purchase 8.5 million shares of BZNE common stock at an exercise price of $0.40 per share. In July 2012, we exercised the BZNE Warrants and received 7,650,000 shares of BZNE common stock. The BZNE Notes are secured pursuant to a security agreement by a first priority lien in the assets of BZNE, including the stock of its subsidiaries. As further consideration for the purchase of the BZNE Notes by us, BZNE granted us exclusive, worldwide distribution rights to its enhanced formulation of propofol, which license was terminated in September 2012. The parties also entered into a license agreement pursuant to which we acquired a world-wide license for the development and commercialization of products utilizing BZNE’s proprietary drug delivery technology, including a technology called QuSomes, exclusively for OPKO in the field of ophthalmology and non-exclusive for all other therapeutic fields, subject in each case to certain excluded products. Refer to Note 9. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">We have accounted for the BZNE Notes as an investment, available for sale. We recorded the BZNE Notes and BZNE Warrants at fair value on the date of acquisition. We record changes in fair value for the BZNE Notes as an unrealized gain or loss in Other comprehensive loss each reporting period and we record changes in fair value for the beneficial conversion feature of the BZNE Notes in Other income (expense), net in our Condensed Consolidated Statements of Operations. Refer to Note 7. The stock market trading activity in BZNE does not represent an active market and as such, we determined the fair market value utilizing a business enterprise valuation approach in order to determine the fair value of our investment. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">In August 2011, we made an investment in Neovasc Inc. (“Neovasc”), a Canadian publicly-traded medical technology company based in Vancouver, Canada. Neovasc is developing devices to treat cardiovascular diseases and is also a leading supplier of tissue components for the manufacturers of replacement heart valves. We invested $2.0 million and received two-million Neovasc common shares, and two-year warrants to purchase an additional one-million shares for $1.25 a share. We recorded the warrants on the date of grant at their estimated fair value of $0.7 million using the Black-Scholes-Merton Model. Prior to the warrants being readily convertible into cash, we recorded an unrealized gain of $0.2 million in Other comprehensive loss. We record changes in fair value for the Neovasc warrants in Other income (expense), net in our Condensed Consolidated Statement of Operations. Refer to Note 7. We also entered into an agreement with Neovasc to provide strategic advisory services to Neovasc as it continues to develop and commercialize its novel cardiac devices. In connection with the consulting agreement, Neovasc granted us 913,750 common stock options. The options were granted at (Canadian) $1.00 per share and vest annually over three years. We valued the options using the Black-Scholes-Merton Model at $0.8 million on the date of grant and will recognize the revenue over four years as Other revenue. In August 2012, Neovasc granted us an additional 86,250 common stock options. The options were granted at (Canadian) $1.30 per share and vested immediately. We valued the options using the Black-Scholes-Merton Model at $0.1 million on the date of grant and will recognize the revenue over three years as Other revenue. We record changes in the fair value of Neovasc options as an unrealized gain or loss in Other comprehensive loss each reporting period. Refer to Note 7. The closing price of Neovasc was $1.39 per share (Canadian) on September 30, 2012. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">In December 2010, we entered into a license agreement with TESARO, Inc. (“TESARO”) granting TESARO exclusive rights to the development, manufacture, commercialization and distribution of rolapitant and a related compound (the “TESARO License”). In connection with the TESARO License, we also received an equity position in TESARO. We recorded the equity investment at $0.7 million, the estimated fair value of the TESARO common stock based on a discounted cash flow model. Neither we nor our related parties have the ability to significantly influence TESARO and as such, we accounted for our investment in TESARO under the cost method until June 2012 on which date, TESARO had an initial public offering. As a result of the initial public offering, we determined TESARO had a readily determinable fair value and we changed the accounting for our investment in TESARO from a cost method investment to an investment, available for sale, and we recorded an unrealized gain in Other comprehensive loss of $5.3 million. We record changes in the fair value as an unrealized gain or loss in Other comprehensive loss each reporting period. Refer to Note 7. The closing price of TESARO was $14.23 per share on September 30, 2012. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"> In November 2010, we made a $0.7 million investment in Fabrus, Inc. (“Fabrus”), a privately-held early stage biotechnology company with next generation therapeutic antibody drug discovery and development capabilities. Fabrus is using its proprietary antibody screening and engineering approach to discover promising lead compounds against several important oncology targets. Our investment was part of a $2.1 million financing for Fabrus and included other related parties. Refer to Note 9. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">In September 2009, we entered into an agreement pursuant to which we invested $2.5 million in cash in Cocrystal Discovery, Inc., a privately-held biopharmaceutical company (“Cocrystal”), in exchange for 1,701,723 shares of Cocrystal’s Convertible Series A preferred stock. Cocrystal is focused on the discovery and development of novel antiviral drugs using a combination of protein structure-based approaches. Refer to Note 9. In October 2011, Cocrystal received an investment of $7.5 million from Teva Pharmaceutical Industries Ltd. (“Teva”). Dr. Phillip Frost, our Chief Executive Officer and Chairman of our Board of Directors, is Chairman of the Board of Directors of Teva. In connection with that investment, we determined Cocrystal no longer meets the definition of a variable interest entity as it has sufficient capital to carry out its principal activities without additional financial support. As a result of our and our related parties’ ownership interest, we and our related parties have the ability to significantly influence Cocrystal, and we account for our investment under the equity method. </font></p> <p style="margin-top:0px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">In June 2009, we entered into a stock purchase agreement with Sorrento Therapeutics, Inc. (“Sorrento”), a publicly-held company with a technology for generating fully human monoclonal antibodies, pursuant to which we invested $2.3 million in Sorrento. The closing stock price for Sorrento’s common stock, a thinly-traded stock, as quoted on the over-the-counter markets was $0.25 per share on September 30, 2012. Refer to Note 9. </font></p> <p style="margin-top:18px;margin-bottom:0px; margin-left:4%"><font style="font-family:times new roman" size="2"><i>Variable interest entities </i></font></p> <p style="margin-top:6px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">We have determined that we hold variable interests in two entities (“VIE”), Fabrus and BZNE. We made this determination as a result of our assessment that they do not have sufficient resources to carry out their principal activities without additional financial support. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">In order to determine the primary beneficiary of Fabrus, we evaluated our investment and our related parties’ investment, as well as our investment combined with the related party group’s investment to identify if we had the power to direct the activities that most significantly impact the economic performance of Fabrus. The related party group when considering our investment in Fabrus includes the Company, Frost Gamma Investments Trust, of which Dr. Frost is the sole trustee (the “Gamma Trust”), Hsu Gamma Investment, L.P., of which Dr. Jane Hsiao is the general partner (“Hsu Gamma”), and the Richard Lerner Family Trust, of which Dr. Richard Lerner is the general partner. Drs. Frost, Hsiao and Lerner are all members of our Board of Directors. As of September 30, 2012, we own approximately 13% of Fabrus and Drs. Frost, Hsiao and Lerner own a total of 24% of Fabrus’ voting stock on an “as converted” basis, including 16% held by the Gamma Trust. Drs. Frost and Hsiao currently serve on the board of directors of Fabrus and represent 40% of its board. Based on this analysis, we determined that neither we nor our related parties have the power to direct the activities of Fabrus. However, we did determine that our related parties can significantly influence the success of Fabrus through our board representation and voting power. Accordingly, as we and our related parties have the ability to exercise significant influence over Fabrus’ operations, we account for our investment in Fabrus under the equity method. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">In order to determine the primary beneficiary of BZNE, we evaluated our investment and our related parties’ investments, as well as our investment combined with the related party group’s investments to identify if we had the power to direct the activities that most significantly impact the economic performance of BZNE. We determined that power to direct the activities that most significantly impact BZNE’s economic performance is conveyed through the board of directors of BZNE and no entity is able to appoint the BZNE governing body that oversees its executive management team. Based on the capital structure, governing documents and overall business operations of BZNE, we determined that, while a VIE, no single entity has the power to direct the activities that most significantly impact BZNE’s economic performance. However, we determined that we and our related parties can significantly influence the success of BZNE through our rating power. As such, we account for investment in BZNE under the equity method. </font></p> <p style="font-size:1px;margin-top:12px;margin-bottom:0px"> </p> <p style="margin-top:0px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">The total assets, liabilities, and net losses of our equity method investees as of and for the nine months ended September 30, 2012 were $29.6 million, $11.0 million, and $11.4 million, respectively. The following table reflects our maximum exposure, accounting method, ownership interest and underlying equity in net assets of each of our investments: </font></p> <p style="font-size:12px;margin-top:0px;margin-bottom:0px"> </p> <table cellspacing="0" cellpadding="0" width="100%" border="0" style="border-collapse:collapse; text-align: left" align="center"> <!-- Begin Table Head --> <tr> <td width="28%"> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="4%"> </td> <td width="38%"> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td valign="bottom" nowrap="nowrap"> <p style="margin-top:0px;margin-bottom:0px"><font style="font-family:times new roman" size="1">(Dollars in thousands)</font></p> <p style="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000;width:70pt"><font style="font-family:times new roman" size="1"> Investee Name</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1"><b></b><b></b><b></b><b></b>Year Acquired</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" style="border-bottom:1px solid #000000"> <p style="margin-top:0px;margin-bottom:1px"><font style="font-family:times new roman" size="1"><b></b><b></b><b></b><b></b><b></b><b></b>Accounting Method</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Ownership<br />September 30,<br />2012</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1"><b></b><b></b>Investment</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1"><b></b><b></b>Underlying<br />equity in net<br />assets</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <!-- End Table Head --> <!-- Begin Table Body --> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Sorrento</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2009</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">Equity method</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">19</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">% </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,300</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,596</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Cocrystal</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2009</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">Equity method</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">16</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">% </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,500</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,012</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Neovasc</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2011</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">Equity method, cost (warrants)</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">4</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">% </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,013</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">146</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Fabrus</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2010</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">VIE, equity method</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">13</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">% </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">650</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">53</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">BZNE common stock</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2012</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">VIE, equity method</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">12</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">% </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,276</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(9</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr> <td valign="top" colspan="7"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Less: accumulated losses in investees</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(4,115</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top" colspan="7"> <p style="margin-left:5.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total carrying value of equity method investees</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">4,624</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">BZNE Note and conversion feature</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2012</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">VIE, investment available for sale</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">N/A</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,700</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">ChromaDex</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2012</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">Investment, available for sale</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">% </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,000</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Neovasc options</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2011</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">Investment, available for sale</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">N/A</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">925</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">TESARO</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2010</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">Investment, available for sale</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">% </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">731</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top" colspan="7"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Plus: unrealized gains on investments, options and warrants, net</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">6,018</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top" colspan="7"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total carrying value of investments, available for sale</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">10,374</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">14,998</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <!-- End Table Body --> </table>
</us-gaap:BusinessCombinationDisclosureTextBlock>
<!-- End Block Tagged Note --> <!-- Begin Block Tagged Note -->
<us-gaap:DisposalGroupsIncludingDiscontinuedOperationsDisclosureTextBlock contextRef="Jan-01-2012_Sep-30-2012">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Note 6 - us-gaap:DisposalGroupsIncludingDiscontinuedOperationsDisclosureTextBlock--> <p style="margin-top:18px;margin-bottom:0px"><font style="font-family:times new roman" size="2"><b>NOTE 6 DISCONTINUED OPERATIONS </b></font></p> <p style="margin-top:6px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">In September 2011, we entered into an agreement with Optos, Inc., a subsidiary of Optos plc (collectively “Optos”) to sell our ophthalmic instrumentation business. Upon closing in October 2011, we received $17.5 million of cash and will receive royalties up to $22.5 million on future sales. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">The assets and liabilities related to our instrumentation business have identifiable cash flows that are independent of the cash flows of other groups of assets and liabilities and we will not have a significant continuing involvement with the related products beyond one year after the closing of the transaction. Therefore, the accompanying Condensed Consolidated Balance Sheets report the assets and liabilities related to our instrumentation business as discontinued operations in all periods presented, and the results of operations related to our instrumentation business have been classified as discontinued operations in the accompanying Condensed Consolidated Statements of Operations for all periods presented. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">The following table presents the major classes of assets and liabilities that have been presented as assets of discontinued operations and liabilities of discontinued operations in the accompanying Condensed Consolidated Balance Sheets: </font></p> <p style="font-size:12px;margin-top:0px;margin-bottom:0px"> </p> <table cellspacing="0" cellpadding="0" width="76%" border="0" style="border-collapse:collapse; text-align: left" align="center"> <!-- Begin Table Head --> <tr> <td width="74%"> </td> <td valign="bottom" width="10%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="10%"> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td valign="bottom" nowrap="nowrap"><font style="font-family:times new roman" size="1">(In thousands)</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">September 30,</font><br /><font style="font-family:times new roman" size="1">2012</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">December 31,</font><br /><font style="font-family:times new roman" size="1">2011</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <!-- End Table Head --> <!-- Begin Table Body --> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Assets:</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Other current assets</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">4</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total assets of discontinued operations</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">4</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Liabilities:</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Trade accounts payable</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Accrued expenses and other liabilities</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">173</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total liabilities of discontinued operations</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">174</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <!-- End Table Body --> </table> <p style="font-size:1px;margin-top:12px;margin-bottom:0px"> </p> <p style="margin-top:0px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">The following table presents summarized financial information for the discontinued operations included in the Condensed Consolidated Statements of Operations: </font></p> <p style="font-size:12px;margin-top:0px;margin-bottom:0px"> </p> <table cellspacing="0" cellpadding="0" width="92%" border="0" style="border-collapse:collapse; text-align: left" align="center"> <!-- Begin Table Head --> <tr> <td width="72%"> </td> <td valign="bottom" width="3%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="3%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="3%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="3%"> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="6" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">For the three months  ended</font><br /><font style="font-family:times new roman" size="1">September 30,</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="6" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">For the nine months  ended</font><br /><font style="font-family:times new roman" size="1">September 30,</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <tr> <td valign="bottom" nowrap="nowrap"> <p style="border-bottom:1px solid #000000;width:45pt"><font style="font-family:times new roman" size="1">(In thousands)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">2012</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">2011</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">2012</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">2011</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <!-- End Table Head --> <!-- Begin Table Body --> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total revenue</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">730</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">4,142</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Operating income (loss) </font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">183</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(1,481</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">183</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(2,819</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Income (loss) before provision for income taxes</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">183</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(1,487</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">183</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(2,841</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Net income (loss)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">183</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(1,487</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">183</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(2,841</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <!-- End Table Body --> </table> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">The income from discontinued operations for the three and nine months ended September 30, 2012 primarily represents collection of an accounts receivable balance retained as part of the sale to Optos. </font></p>
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<!-- End Block Tagged Note --> <!-- Begin Block Tagged Note -->
<us-gaap:FairValueDisclosuresTextBlock contextRef="Jan-01-2012_Sep-30-2012">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Note 7 - us-gaap:FairValueDisclosuresTextBlock--> <p style="margin-top:18px;margin-bottom:0px"><font style="font-family:times new roman" size="2"><b>NOTE 7 FAIR VALUE MEASUREMENTS </b></font></p> <p style="margin-top:6px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">We record fair value at an exit price, representing the amount that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants. As such, fair value is a market-based measurement that should be determined based on assumptions that market participants would use in pricing an asset or liability. We utilize a three-tier fair value hierarchy, which prioritizes the inputs used in measuring fair value. These tiers include: Level 1, defined as observable inputs such as quoted prices in active markets; Level 2, defined as inputs other than quoted prices in active markets that are either directly or indirectly observable; and Level 3, defined as unobservable inputs in which little or no market data exists, therefore requiring an entity to develop its own assumptions. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">A summary of our investments as of September 30, 2012, classified as available for sale, and carried at fair value is as follows: </font></p> <p style="font-size:12px;margin-top:0px;margin-bottom:0px"> </p> <table cellspacing="0" cellpadding="0" width="100%" border="0" style="border-collapse:collapse; text-align: left" align="center"> <!-- Begin Table Head --> <tr> <td width="63%"> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td valign="bottom" nowrap="nowrap"> <p style="border-bottom:1px solid #000000;width:45pt"><font style="font-family:times new roman" size="1">(In thousands)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Amortized</font><br /><font style="font-family:times new roman" size="1">cost</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Gross</font><br /><font style="font-family:times new roman" size="1">unrealized</font><br /><font style="font-family:times new roman" size="1"> gains in</font><br /><font style="font-family:times new roman" size="1">Accumulated</font><br /><font style="font-family:times new roman" size="1">OCI</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Gross</font><br /><font style="font-family:times new roman" size="1">unrealized</font><br /><font style="font-family:times new roman" size="1"> losses in</font><br /><font style="font-family:times new roman" size="1">Accumulated<br />OCI</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Gain/(Loss)</font><br /><font style="font-family:times new roman" size="1">in</font><br /><font style="font-family:times new roman" size="1"> Accumulated</font><br /><font style="font-family:times new roman" size="1">Deficit</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Fair</font><br /><font style="font-family:times new roman" size="1">Value</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <!-- End Table Head --> <!-- Begin Table Body --> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Common stock investments</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,731</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">5,407</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">7,138</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">BZNE Note and conversion feature</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,700</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">53</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">287</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,040</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Neovasc common stock options</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">925</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">249</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">119</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,293</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Neovasc common stock warrants</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">659</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">194</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(375</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">478</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total assets</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">5,015</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">5,903</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">31</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">10,949</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <!-- End Table Body --> </table> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">Any future fluctuation in fair value related to these instruments that is judged to be temporary, including any recoveries of previous write-downs, would be recorded in Accumulated other comprehensive income. If we determine that any future valuation adjustment was other-than-temporary, we would record a loss during the period that such determination is made. </font></p> <p style="font-size:1px;margin-top:12px;margin-bottom:0px"> </p> <p style="margin-top:0px;margin-bottom:0px"><font style="font-family:times new roman" size="2">Our financial assets and liabilities measured at fair value on a recurring basis are as follows: </font></p> <p style="font-size:12px;margin-top:0px;margin-bottom:0px"> </p> <table cellspacing="0" cellpadding="0" width="92%" border="0" style="border-collapse:collapse; text-align: left" align="center"> <!-- Begin Table Head --> <tr> <td width="64%"> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="14" nowrap="nowrap" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Fair value measurements as of September 30, 2012</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <tr> <td valign="bottom" nowrap="nowrap"> <p style="border-bottom:1px solid #000000;width:45pt"><font style="font-family:times new roman" size="1">(In thousands)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Quote prices<br />in active<br />markets for<br />identical</font><br /><font style="font-family:times new roman" size="1"> assets</font><br /><font style="font-family:times new roman" size="1">(Level 1)</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Significant<br />other</font><br /><font style="font-family:times new roman" size="1">observable<br />inputs</font><br /> <font style="font-family:times new roman" size="1">(Level 2)</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Significant</font><br /><font style="font-family:times new roman" size="1">unobservable<br />inputs</font><br /><font style="font-family:times new roman" size="1"> (Level 3)</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Total</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <!-- End Table Head --> <!-- Begin Table Body --> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Assets:</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Money market funds</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">14,505</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">14,505</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">US Treasury securities</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">14,997</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">14,997</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Certificates of deposit</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">10,423</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">10,423</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Forward contracts</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">59</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">59</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Common stock investments</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">7,138</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">7,138</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">BZNE Note and conversion feature</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,040</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,040</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Neovasc common stock options</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,293</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,293</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Neovasc common stock warrants</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">478</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">478</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total assets</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">36,640</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">12,253</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,040</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">50,933</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Liabilities:</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Deferred acquisition payments, net of discount</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">9,752</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">9,752</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">CURNA contingent consideration</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">510</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">510</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">OPKO Diagnostics contingent consideration</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">15,098</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">15,098</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">FineTech contingent consideration</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">5,042</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">5,042</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Farmadiet contingent consideration</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,251</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,251</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total liabilities</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">31,653</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">31,653</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <!-- End Table Body --> </table> <p style="margin-top:12px;margin-bottom:0px"><font style="font-family:times new roman" size="2">The following table reconciles the beginning and ending balances of our Level 3 assets and liabilities: </font></p> <p style="font-size:12px;margin-top:0px;margin-bottom:0px"> </p> <table cellspacing="0" cellpadding="0" width="76%" border="0" style="border-collapse:collapse; text-align: left" align="center"> <!-- Begin Table Head --> <tr> <td width="64%"> </td> <td valign="bottom" width="7%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="7%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="7%"> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td valign="bottom" nowrap="nowrap"> <p style="border-bottom:1px solid #000000;width:45pt"><font style="font-family:times new roman" size="1">(In thousands)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">BZNE<br />Note and<br />conversion<br />feature</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Contingent<br />consideration</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Deferred<br />acquisition<br />payments,<br />net of discount</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <!-- End Table Head --> <!-- Begin Table Body --> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Balance at December 31, 2011</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">18,002</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Additions</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,700</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,234</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">9,673</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Change in fair value included in:</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:5.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Operating expenses</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,665</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:5.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Other income and (expense), net</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,563</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">79</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:5.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Other comprehensive loss</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font><br /></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">53</font><br /></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font><br /></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Transfer out to equity method investment</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(1,276</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Balance at September 30, 2012</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,040</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">21,901</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">9,752</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <!-- End Table Body --> </table> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">Our U.S. Treasury security matures on December 20, 2012 ($15.0 million). We intend to hold the U.S. Treasury security until its maturity. Of the $21.9 million of contingent consideration, $8.0 million is recorded in Accrued expenses and $13.9 million is recorded in Other long-term liabilities. We valued the contingent consideration utilizing a discounted cash flow model for the expected payments. The carrying value of our other assets and liabilities approximates their fair value due to their short-term nature. </font></p>
</us-gaap:FairValueDisclosuresTextBlock>
<!-- End Block Tagged Note --> <!-- Begin Block Tagged Note -->
<us-gaap:DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock contextRef="Jan-01-2012_Sep-30-2012">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Note 8 - us-gaap:DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock--> <p style="margin-top:18px;margin-bottom:0px"><font style="font-family:times new roman" size="2"><b>NOTE 8 DERIVATIVE CONTRACTS </b></font></p> <p style="margin-top:6px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">We enter into foreign currency forward exchange contracts to cover the risk of exposure to exchange rate differences arising from inventory purchases on letters of credit. Under these forward contracts, for any rate above or below the fixed rate, we receive or pay the difference between the spot rate and the fixed rate for the given amount at the settlement date. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">We record derivative financial instruments as Accrued expenses or Other current assets on our Condensed Consolidated Balance Sheets at their fair value and the corresponding gain or loss as Other income (expense), net. To qualify the derivative instrument as a hedge, we are required to meet strict hedge effectiveness and contemporaneous documentation requirements at the initiation of the hedge and assess the hedge effectiveness on an ongoing basis over the life of the hedge. At September 30, 2012, the forward contracts did not meet the documentation requirements to be designated as hedges. Accordingly, we recognize all changes in fair values in Other income (expense), net. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"> The outstanding forward contracts at September 30, 2012, have been recorded at fair value and their maturity details are as follows (dollars in thousands): </font></p> <p style="font-size:12px;margin-top:0px;margin-bottom:0px"> </p> <table cellspacing="0" cellpadding="0" width="84%" border="0" style="border-collapse:collapse; text-align: left" align="center"> <!-- Begin Table Head --> <tr> <td width="60%"> </td> <td valign="bottom" width="10%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="10%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="10%"> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td valign="bottom" nowrap="nowrap"> <p style="border-bottom:1px solid #000000;width:62pt"><font style="font-family:times new roman" size="1">Days until maturity</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Contract value</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Fair value at</font><br /><font style="font-family:times new roman" size="1">September 30,  2012</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Effect on loss</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <!-- End Table Head --> <!-- Begin Table Body --> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">0 to 30</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,798</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,834</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(36</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">31 to 60</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,273</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,288</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(15</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">61 to 90</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">320</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">328</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(8</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">91 to 120</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">121 to 180</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">More than 180</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">3,391</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">3,450</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(59</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <!-- End Table Body --> </table> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">In addition, the Neovasc warrants and vested Neovasc options are accounted for as derivatives as they are readily convertible into cash. As a result, the fluctuations in fair value are recorded in Other income (expense), net as an unrealized gain or loss. We value the Neovasc warrants and options based on the Black-Scholes-Merton valuation model. The conversion feature of the BZNE Notes is also accounted for as a derivative and the changes in the fair value are recorded in Other income (expense), net. </font></p>
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<us-gaap:RelatedPartyTransactionsDisclosureTextBlock contextRef="Jan-01-2012_Sep-30-2012">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Note 9 - us-gaap:RelatedPartyTransactionsDisclosureTextBlock--> <p style="margin-top:18px;margin-bottom:0px"><font style="font-family:times new roman" size="2"><b>NOTE 9 RELATED PARTY TRANSACTIONS </b></font></p> <p style="margin-top:6px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">During the nine months ended September 30, 2012, our FineTech subsidiary recorded revenue of $0.2 million for the sale of APIs to Teva. Dr. Frost serves as the Chairman of the Board of Directors of Teva. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">In February 2012, we entered into a cooperative research funding and option agreement with The Scripps Research Institute (“TSRI”) to support research for the development of novel oligomeric compounds relating to our molecular diagnostics technology (the “Research Agreement”). Pursuant to the Research Agreement, we agreed to provide funding of approximately $0.9 million annually over a five year period. In conjunction with entering into the Research Agreement, we also entered into a license agreement with TSRI for technology relating to libraries of peptide tertiary amides. In addition, we entered into a second license with TSRI for technology relating to highly selective inhibitors of c-Jun-N-Terminal Kinases that may be useful for the treatment of various diseases, including Parkinson’s disease. Dr. Frost serves as a Trustee for TSRI and Dr. Lerner served as its President until December 2011. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">In February 2012, we made a $1.0 million investment in ChromaDex. Other investors participating in the private financing included the Gamma Trust, Hsu Gamma, and Dr. Lerner. Mr. Curt Lockshin, our Vice President, Corporate R&D Initiatives, serves as a member of the Board of Directors of ChromaDex. Following our investment, we own 1.5% of ChromaDex, the Gamma Trust owns approximately 16% of ChromaDex; Hsu Gamma owns approximately 1%; and Dr. Lerner owns less than 1% of ChromaDex. Refer to Note 5. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"> In February 2012, we purchased from the BZNE Notes, convertible into BZNE common stock at a price equal to $0.20 per common share, which BZNE Notes are due and payable on February 24, 2014 and ten year warrants to purchase 8.5 million shares of BZNE common stock at an exercise price of $0.40 per share. Refer to Note 5. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"> Mr. Roberto Prego Novo is the Chairman of BZNE and presently serves as a consultant to us. Dr. Frost and Mr. Prego Novo previously invested in BZNE in February and March, 2011. On May 16, 2011, BZNE acquired the assets and assumed the liabilities of Aero Pharmaceuticals, Inc. (“Aero”) in exchange for which BZNE issued an aggregate of 8,331,396 shares of its restricted common stock to Aero. On September 21, 2011, BZNE issued an additional 13,914 shares to Aero due to the late filing of a registration statement. Prior to the transaction, Dr. Frost, through the Gamma Trust, beneficially owned approximately 46% of Aero’s issued and outstanding common stock; Mr. Prego Novo owned approximately 23% of Aero’s issued and outstanding common stock through Olyrca Trust; and Dr. Hsiao beneficially owned approximately 12% of Aero’s issued and outstanding common stock. Each of Drs. Frost and Hsiao and Mr. Prego Novo beneficially owned approximately 9.2%, 1.7%, and 8.2% of BZNE, respectively, following the purchase of Aero by BZNE. Mr. Rubin beneficially own less than 1% of BZNE as a result of his prior ownership of Aero shares. In April 2012 and June 2012, Dr. Frost, through the Gamma Trust, also made loans to BZNE in the principal amounts of $0.3million and $0.1 million, respectively, which were initially secured by a first priority lien on particular BZNE receivables. The notes to Frost Gamma were subsequently amended and Frost Gamma no longer holds a security interest in the BZNE receivables. </font></p> <p style="font-size:1px;margin-top:12px;margin-bottom:0px"> </p> <p style="margin-top:0px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">In August 2011, we made an investment in Neovasc. Refer to Note 5. Dr. Frost and other members of our management are shareholders of Neovasc. Prior to the investment, Dr. Frost beneficially owned approximately 36% of Neovasc, Dr. Hsiao owned approximately 6%, and Mr. Rubin owned less than 1%. Dr. Hsiao and Mr. Rubin also serve on the Board of Directors for Neovasc. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"> In March 2011, we issued 27,000,000 shares of our Common Stock. The 27,000,000 shares of our Common Stock issued included an aggregate of 3,733,000 shares purchased by the Gamma Trust and Hsu Gamma at the public offering price. The Gamma Trust purchased an aggregate of 3,200,000 shares for approximately $12.0 million, and Hsu Gamma purchased an aggregate of 533,000 shares for approximately $1.9 million. Jefferies & Company, Inc. and J.P. Morgan Securities LLC acted as joint book-running managers for the offering. UBS Investment Bank and Lazard Capital Markets LLC acted as co-lead managers for the offering and Ladenburg Thalmann & Co. Inc., a subsidiary of Ladenburg Thalmann Financial Services Inc., acted as co-manager for the offering. Dr. Frost is the Chairman of the Board of Directors and principal shareholder of Ladenburg Thalmann Financial Services Inc. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">In January 2011, we entered into a definitive agreement with CURNA, Inc. (“CURNA”) and each of CURNA’s stockholders and option holders, pursuant to which we agreed to acquire all of the outstanding stock of CURNA in exchange for $10.0 million in cash, plus $0.6 million in liabilities, of which $0.5 million was paid at closing. At the time of the transaction, TSRI owned approximately 4% of CURNA. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">We had a $12.0 million line of credit with the Frost Group, LLC (the “Frost Group”) which expired on March 31, 2012. The Frost Group members include a trust controlled by Dr. Frost, who is the Company’s Chief Executive Officer and Chairman of our Board of Directors, Dr. Hsiao, who is the Vice Chairman of our Board of Directors and Chief Technical Officer and Mr. Rubin who is Executive Vice President — Administration and a director of the Company. On June 2, 2010 we repaid all amounts outstanding on the line of credit including $12.0 million in principal and $4.1 million in interest. We did not have any borrowings under the line of credit at any time during 2011 and 2012. We were obligated to pay interest upon maturity, capitalized quarterly, on any outstanding borrowings under the line of credit at an 11% annual rate. The line of credit was collateralized by all of our U.S. personal property except our intellectual property. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"> In November 2010, we made an investment in Fabrus. In exchange for the investment, we acquired approximately 13% of Fabrus on a fully diluted basis. Our investment was part of a $2.1 million financing for Fabrus. Other investors participating in the financing include the Gamma Trust and Hsu Gamma. In connection with the financing, Drs. Frost and Hsiao joined the Fabrus Board of Managers. Dr. Lerner owns approximately 5% of Fabrus. Mr. Vaughn Smider, Founder and CEO of Fabrus, is an Assistant Professor at TSRI. Dr. Frost serves as a Trustee for TSRI and Dr. Lerner served as President of TSRI until December 2011. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">In July 2010, we entered into a use agreement for approximately 1,100 square feet of space in Jupiter, Florida to house our molecular diagnostics operations with TSRI. Pursuant to the terms of the use agreement, which was effective as of November 1, 2009, gross rent was approximately $40 thousand per year for a two-year term. We ceased use of this space in September 2011. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">In June 2010, we entered into a cooperative research and development agreement with Academia Sinica in Taipei, Taiwan (“Academia Sinica”), for pre-clinical work for a compound against various forms of cancer (the “Academia Sinica Agreement”). Dr. Alice Yu, a member of our Board of Directors, is a Distinguished Research Fellow and Associate Director at the Genomics Research Center, Academia Sinica (“Genomics Research Center”). In connection with the Academia Sinica Agreement, we are required to pay Academia Sinica approximately $0.2 million over the term of such agreement. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">In July 2009, we entered into a worldwide exclusive license agreement with Academia Sinica for a new technology to develop protein vaccines against influenza and other viral infections. Effective March 5, 2010, the Frost Group assigned two license agreements with Academia Sinica to us. The license agreements pertain to alpha-galactosyl ceramide analogs and their use as immunotherapies and peptide ligands in the diagnosis and treatment of cancer. In connection with the assignment of the two licenses, we agreed to reimburse $0.1 million to the Frost Group for the licensing fees previously paid by the Frost Group to Academia Sinica, as well as reimbursement of certain expenses totaling $50 thousand. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">Effective September 2009, we entered into an agreement pursuant to which we invested $2.5 million in Cocrystal in exchange for 1,701,723 shares of Cocrystal’s Convertible Series A preferred stock. A group of investors, led by the Frost Group (the “Cocrystal Investors”), previously invested $5.0 million in Cocrystal, and agreed to invest an additional $5 million payable in two equal installments in September 2009 and March 2010. As a result of an amendment to the Cocrystal Investors’ agreements dated June 9, 2009, we, rather than the Cocrystal Investors, made the first installment investment ($2.5 million) on September 21, 2009. Refer to Note 5. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">In June 2009, we entered into an agreement to lease approximately 10,000 square feet of space in Hialeah, Florida, to house manufacturing and service operations for our ophthalmic instrumentation business from an entity controlled by Drs. Frost and Hsiao. Effective as of July 1, 2011, the lease was amended to include an additional 5,000 square feet of space at the same rate per square foot then in effect under the lease. Following the amendment, gross rent payable under the lease was $0.2 million per year. Upon the closing of the sale of our instrumentation business to Optos, we assigned the lease to Optos. Refer to Note 6. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">In June 2009, we entered into a stock purchase agreement with Sorrento, pursuant to which we invested $2.3 million in Sorrento. Refer to Note 5. In exchange for the investment, we acquired approximately one-third of the outstanding common shares of Sorrento and received a fully-paid, exclusive license to the Sorrento antibody library for the discovery and development of therapeutic antibodies in the field of ophthalmology. On September 21, 2009, Sorrento entered into a merger transaction with Quikbyte Software, Inc. (“Quikbyte”). Prior to the merger transaction, certain investors, including Dr. Frost and other members of our management group, made an investment in Quikbyte. Dr. Lerner serves as a consultant and scientific advisory board member to Sorrento and owns less than one percent of its shares. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">In November 2007, we entered into an office lease with Frost Real Estate Holdings, LLC (“Frost Holdings”), an entity affiliated with Dr. Frost. The lease is for approximately 8,300 square feet of space in an office building in Miami, Florida, where the Company’s principal executive offices are located. The lease provides for payments of approximately $18 thousand per month in the first year increasing annually to $24 thousand per month by the fifth year, plus applicable sales tax. The rent is inclusive of operating expenses, property taxes and parking. The rent for the first year was reduced to reflect a $30 thousand credit for the costs of tenant improvements. In August 2012, we entered into a six-month extension on the same terms as the 2007 expiring lease. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">We reimburse Dr. Frost for Company-related use by Dr. Frost and our other executives of an airplane owned by a company that is beneficially owned by Dr. Frost. We reimburse Dr. Frost in an amount equal to the cost of a first class airline ticket between the travel cities for each executive, including Dr. Frost, traveling on the airplane for Company-related business. We do not reimburse Dr. Frost for personal use of the airplane by Dr. Frost or any other executive; nor do we pay for any other fixed or variable operating costs of the airplane. For the three and nine months ended September 30, 2012, we reimbursed Dr. Frost approximately $52 thousand and $181 thousand, respectively, for Company-related travel by Dr. Frost and other OPKO executives. For the three and nine months ended September 30, 2011, we reimbursed Dr. Frost approximately $14 thousand and $127 thousand, respectively, for Company-related travel by Dr. Frost and other OPKO executives. </font></p>
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<us-gaap:CommitmentsAndContingenciesDisclosureTextBlock contextRef="Jan-01-2012_Sep-30-2012">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Note 10 - us-gaap:CommitmentsAndContingenciesDisclosureTextBlock--> <p style="margin-top:18px;margin-bottom:0px"><font style="font-family:times new roman" size="2"><b>NOTE 10 COMMITMENTS AND CONTINGENCIES </b></font></p> <p style="margin-top:6px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">In connection with our acquisitions of CURNA, OPKO Diagnostics, FineTech and Farmadiet we agreed to pay future consideration upon the achievement of certain events. As a result, we recorded $21.9 million as contingent consideration, with $8.0 million recorded within Accrued expenses and $13.9 million recorded within Other long-term liabilities in the accompanying Condensed Consolidated Balance Sheets as of September 30, 2012. Refer to Note 5. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">On or around October 30, 2012, we received a letter from counsel to Optos making certain indemnity claims against us in connection with the sale of our instrumentation business. Refer to Note 6. It is too early to assess the likelihood of litigation in this matter or the probability of a favorable or unfavorable outcome. However, we do not currently believe this matter will have a material impact on our results of operations or financial condition. </font></p> <p style="font-size:1px;margin-top:12px;margin-bottom:0px"> </p> <p style="margin-top:0px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">We are a party to litigation in the ordinary course of business. We do not believe that any such litigation will have a material adverse effect on our business, financial condition, or results of operations. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">We expect to incur substantial losses as we continue the development of our product candidates, continue our other research and development activities, and establish a sales and marketing infrastructure in anticipation of the commercialization of our diagnostic and pharmaceutical product candidates. We currently have limited commercialization capabilities and it is possible that we may never successfully commercialize any of our diagnostic and pharmaceutical product candidates. We do not currently generate revenue from any of our diagnostic and pharmaceutical product candidates. Our research and development activities are projected to expand over a period of time and will require further resources if we are to be successful in commercializing our product candidates. As a result, we believe that our operating losses are likely to be substantial over the next several years. We may need to obtain additional funds to further develop our research and development programs, and there can be no assurance that additional capital will be available to us on acceptable terms, or at all. </font></p>
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<us-gaap:SegmentReportingDisclosureTextBlock contextRef="Jan-01-2012_Sep-30-2012">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Note 11 - us-gaap:SegmentReportingDisclosureTextBlock--> <p style="margin-top:18px;margin-bottom:0px"><font style="font-family:times new roman" size="2"><b>NOTE 11 SEGMENTS </b></font></p> <p style="margin-top:6px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">We currently manage our operations in one reportable segment, pharmaceuticals. The pharmaceuticals segment consists of two operating segments, our (i) pharmaceutical research and development segment, which is focused on the research and development of pharmaceutical products, diagnostic tests and vaccines, and (ii) the pharmaceutical operations we acquired in Chile, Spain, Mexico, and Israel through the acquisition of OPKO Chile, Farmadiet, Exakta-OPKO, and FineTech, respectively. We evaluate the performance of each segment based on operating profit or loss. There is no inter-segment allocation of interest expense and income taxes. We previously recorded our ophthalmic instrumentation business as its own reporting segment. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">Information regarding our operations and assets for the two operating segments and the unallocated corporate operations as well as geographic information are as follows: </font></p> <p style="font-size:12px;margin-top:0px;margin-bottom:0px"> </p> <table cellspacing="0" cellpadding="0" width="92%" border="0" style="border-collapse:collapse; text-align: left" align="center"> <!-- Begin Table Head --> <tr> <td width="66%"> </td> <td valign="bottom" width="3%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="3%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="3%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="3%"> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td valign="bottom"> <font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="6" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">For three months ended<br />September 30,</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="6" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">For the nine months ended<br />September 30,</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <tr> <td valign="bottom" nowrap="nowrap"> <p style="border-bottom:1px solid #000000;width:45pt"><font style="font-family:times new roman" size="1">(In thousands)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">2012</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">2011</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">2012</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">2011</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <!-- End Table Head --> <!-- Begin Table Body --> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Operating loss from continuing operations</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Pharmaceutical</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(5,593</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(262</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(17,053</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(3,601</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Corporate</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(3,776</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(5,542</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(10,504</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(11,113</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr> <td valign="top"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(9,369</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(5,804</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(27,557</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(14,714</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Depreciation and amortization</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Pharmaceutical</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,618</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">997</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">7,315</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,731</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Corporate</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">44</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">43</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">132</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">127</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr> <td valign="top"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,662</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,040</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">7,447</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,858</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Product sales</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">United States</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Chile</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">6,781</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">5,356</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">19,669</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">17,545</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Spain</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,997</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,997</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Israel</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,516</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">4,661</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Mexico</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,201</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,404</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">3,724</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">4,568</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">11,495</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">6,760</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">30,051</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">22,113</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <!-- End Table Body --> </table> <p style="font-size:1px;margin-top:12px;margin-bottom:0px"> </p> <table cellspacing="0" cellpadding="0" width="76%" border="0" style="border-collapse:collapse; text-align: left" align="center"> <!-- Begin Table Head --> <tr> <td width="74%"> </td> <td valign="bottom" width="6%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="6%"> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="6" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">As of</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <tr> <td valign="bottom" nowrap="nowrap"> <p style="border-bottom:1px solid #000000;width:45pt"><font style="font-family:times new roman" size="1">(In thousands)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">September 30,<br />2012</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">December 31,<br />2011</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <!-- End Table Head --> <!-- Begin Table Body --> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Assets:</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Pharmaceutical</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">198,483</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">154,437</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Corporate</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">51,539</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">75,048</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Discontinued operations</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">4</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">250,022</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">229,489</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <!-- End Table Body --> </table> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">During the three and nine months ended September 30, 2012, no customer represented more than 10% of our total revenues. During the three and nine months ended September 30, 2011, our largest customer represented 20% and 18% of our total revenues, respectively. As of September 30, 2012, no customer represented more than 10% of our accounts receivable balance. As of December 31, 2011, one customer represented 29% of our accounts receivable balance. </font></p>
</us-gaap:SegmentReportingDisclosureTextBlock>
<!-- End Block Tagged Note --> <!-- Begin Block Tagged Note -->
<us-gaap:SubsequentEventsTextBlock contextRef="Jan-01-2012_Sep-30-2012">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Note 12 - us-gaap:SubsequentEventsTextBlock--> <p style="margin-top:18px;margin-bottom:0px"><font style="font-family:times new roman" size="2"><b>NOTE 12 SUBSEQUENT EVENTS </b></font></p> <p style="margin-top:6px;margin-bottom:0px; text-indent:4%;padding-bottom:0px;"><font style="font-family:times new roman" size="2">On October 18, 2012, we entered into a definitive merger agreement to acquire Prost-Data, Inc., doing business as OURLab, a Nashville-based CLIA laboratory with 18 phlebotomy sites throughout the U.S. We believe OURLab provides us with a commercial platform to support the U.S. commercial launch of our panel of kallikrein biomarkers and associated algorithm (4Kscore<font style="font-family:times new roman" size="1"><sup>™</sup></font>) for the detection of prostate cancer. We agreed to pay an aggregate purchase price of $40.0 million, of which $9.4 million shall be payable in cash, and $30.6 million payable in shares of our Common Stock, subject to our ability to hold back up to $4.0 million of the cash otherwise payable at closing as escrow for potential indemnity claims. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">On or around October 30, 2012, we received a letter from counsel to Optos making certain indemnity claims against us in connection with the sale of our instrumentation business. Refer to Note 6. It is too early to assess the likelihood of litigation in this matter or the probability of a favorable or unfavorable outcome. However, we do not currently believe this matter will have a material impact on our results of operations or financial condition. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">On October 17, 2012 we completed the acquisition of a forty-five percent stake in a private Israeli company that produces a third-generation hepatitis B vaccine in its biologics manufacturing facility in Rehovot, Israel. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">We have reviewed all subsequent events and transactions that occurred after the date of our September 30, 2012 consolidated balance sheet date, through the time of filing this Quarterly Report on Form 10-Q. </font></p>
</us-gaap:SubsequentEventsTextBlock>
<!-- End Block Tagged Note --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table1 -->
<us-gaap:BasisOfAccountingPolicyPolicyTextBlock contextRef="Jan-01-2012_Sep-30-2012">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table1 - us-gaap:BasisOfAccountingPolicyPolicyTextBlock--> <p style="margin-top:6px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Basis of presentation. </i>The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States and with the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, they do not include all information and notes required by accounting principles generally accepted in the United States for complete financial statements. In the opinion of management, all adjustments (consisting of only normal recurring adjustments) considered necessary to present fairly the Company’s results of operations, financial position and cash flows have been made. The results of operations for the three and nine months ended September 30, 2012 and cash flows for the nine months ended September 30, 2012, are not necessarily indicative of the results of operations and cash flows that may be reported for the remainder of 2012 or for future periods. The unaudited condensed consolidated financial statements should be read in conjunction with the Consolidated Financial Statements and the Notes to Consolidated Financial Statements included in our Annual Report on Form 10-K for the year ended December 31, 2011. </font></p>
</us-gaap:BasisOfAccountingPolicyPolicyTextBlock>
<!-- End Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table1 --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table2 -->
<us-gaap:PriorPeriodReclassificationAdjustmentDescription contextRef="Jan-01-2012_Sep-30-2012">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table2 - us-gaap:PriorPeriodReclassificationAdjustmentDescription--> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Reclassifications. </i>As further discussed in Note 6, the results of operations and the assets and the liabilities related to the instrumentation business have been accounted for as discontinued operations. Accordingly, the results of the operations related to the instrumentation business from prior periods have been reclassified to discontinued operations. </font></p>
</us-gaap:PriorPeriodReclassificationAdjustmentDescription>
<!-- End Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table2 --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table3 -->
<us-gaap:ConsolidationPolicyTextBlock contextRef="Jan-01-2012_Sep-30-2012">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table3 - us-gaap:ConsolidationPolicyTextBlock--> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Principles of consolidation</i>. The accompanying unaudited condensed consolidated financial statements include the accounts of OPKO Health, Inc. and our wholly-owned subsidiaries. All significant intercompany accounts and transactions are eliminated in consolidation. </font></p>
</us-gaap:ConsolidationPolicyTextBlock>
<!-- End Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table3 --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table4 -->
<us-gaap:UseOfEstimates contextRef="Jan-01-2012_Sep-30-2012">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table4 - us-gaap:UseOfEstimates--> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Use of estimates</i>. The preparation of financial statements in conformity with accounting principles generally accepted in the United States of America requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates. </font></p>
</us-gaap:UseOfEstimates>
<!-- End Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table4 --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table5 -->
<us-gaap:CashAndCashEquivalentsPolicyTextBlock contextRef="Jan-01-2012_Sep-30-2012">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table5 - us-gaap:CashAndCashEquivalentsPolicyTextBlock--> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Cash and cash equivalents. </i>Cash and cash equivalents include short-term, interest-bearing instruments with original maturities of 90 days or less at the date of purchase. We also consider all highly liquid investments with original maturities at the date of purchase of 90 days or less as cash equivalents. These investments include money markets, bank deposits, certificates of deposit and U.S. treasury securities. </font></p>
</us-gaap:CashAndCashEquivalentsPolicyTextBlock>
<!-- End Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table5 --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table6 -->
<us-gaap:MarketableSecuritiesPolicy contextRef="Jan-01-2012_Sep-30-2012">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table6 - us-gaap:MarketableSecuritiesPolicy--> <p style="margin-top:0px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Marketable securities. </i>Investments with original maturities of greater than 90 days and remaining maturities of less than one year are classified as marketable securities. Marketable securities include U.S. treasury securities and certificates of deposit. Unrealized gains and losses on investments are included in Accumulated other comprehensive income (“OCI”) as a separate component of shareholders’ equity. Realized gains and losses, dividends, interest income, and declines in value judged to be other-than-temporary credit losses are included in Other income and (expense), net. Amortization of any premium or discount arising at purchase is included in Interest income. </font></p>
</us-gaap:MarketableSecuritiesPolicy>
<!-- End Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table6 --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table7 -->
<us-gaap:InventoryPolicyTextBlock contextRef="Jan-01-2012_Sep-30-2012">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table7 - us-gaap:InventoryPolicyTextBlock--> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Inventories. </i>Inventories are valued at the lower of cost or market (net realizable value). Cost is determined by the first-in, first-out method. We consider such factors as the amount of inventory on hand, estimated time required to sell such inventories, remaining shelf-life, and current market conditions to determine whether inventories are stated at the lower of cost or market. </font></p>
</us-gaap:InventoryPolicyTextBlock>
<!-- End Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table7 --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table8 -->
<us-gaap:RevenueRecognitionPolicyTextBlock contextRef="Jan-01-2012_Sep-30-2012">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table8 - us-gaap:RevenueRecognitionPolicyTextBlock--> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Revenue recognition. </i>Generally, we recognize revenue from product sales when goods are shipped and title and risk of loss transfer to our customers. Our estimates for sales returns and allowances are based upon the historical patterns of products returned and allowances taken, matched against the sales from which they originated, and management’s evaluation of specific factors that may increase the risk of product returns. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">Other revenue includes revenue related to upfront license payments, license fees and milestone payments received through our license, collaboration and commercialization agreements. We analyze our multiple-element arrangements to determine whether the elements can be separated and accounted for individually as separate units of accounting. Other revenue for the three and nine months ended September 30, 2012, includes $0.3 million and $0.7 million, respectively, of revenue related to our consulting agreement with Neovasc, Inc. and to revenue related to molecular diagnostics collaboration agreements. Refer to Note 5. We recognize this revenue on a straight-line basis over the contractual term of the agreements. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">Non-refundable license fees for the out-license of our technology are recognized depending on the provisions of each agreement. We recognize non-refundable upfront license payments as revenue upon receipt if the license has standalone value and the fair value of our undelivered obligations, if any, can be determined. If the license is considered to have standalone value but the fair value of any of the undelivered items cannot be determined, the license payments are recognized as revenue over the period of our performance for such undelivered items or services. License fees with ongoing involvement or performance obligations are recorded as deferred revenue as Accrued expenses or Other long-term liabilities, when received and generally are recognized ratably over the period of such performance obligation only after both the license period has commenced and we have delivered the technology. The assessment of our obligations and related performance periods requires significant management judgment. If an agreement contains research and development obligations, the relevant time period for the research and development phase is based on management estimates and could vary depending on the outcome of clinical trials and the regulatory approval process. Such changes could materially impact the revenue recognized, and as a result, management reviews the estimates related to the relevant time period of research and development on a quarterly basis. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">Revenue from milestone payments related to arrangements under which we have continuing performance obligations are recognized as Other revenue upon achievement of the milestone only if all of the following conditions are met: the milestone payments are non-refundable; there was substantive uncertainty at the date of entering into the arrangement that the milestone would be achieved; the milestone is commensurate with either the vendor’s performance to achieve the milestone or the enhancement of the value of the delivered item by the vendor; the milestone relates solely to past performance; and the amount of the milestone is reasonable in relation to the effort expended or the risk associated with the achievement of the milestone. If any of these conditions are not met, the milestone payments are not considered to be substantive and are, therefore, deferred and recognized as Other revenue over the term of the arrangement as we complete our performance obligations. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">Total deferred revenue recorded as Accrued expenses and Other long-term liabilities at September 30, 2012 and December 31, 2011, was $1.4 million and $0.9 million, respectively. </font></p>
</us-gaap:RevenueRecognitionPolicyTextBlock>
<!-- End Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table8 --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table9 -->
<us-gaap:DerivativesPolicyTextBlock contextRef="Jan-01-2012_Sep-30-2012">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table9 - us-gaap:DerivativesPolicyTextBlock--> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Derivative financial instruments. </i>We record derivative financial instruments on our balance sheet at their fair value and the changes in the fair value are recognized in Other income (expense), net, when they occur, the only exception being derivatives that qualify as hedges. For the derivative instrument to qualify as a hedge, we are required to meet strict hedge effectiveness and contemporaneous documentation requirements at the initiation of the hedge and assess the hedge effectiveness on an ongoing basis over the life of the hedge. At September 30, 2012 and December 31, 2011, our forward contracts for inventory purchases did not meet the documentation requirements to be designated as hedges. Accordingly, we recognize all changes in fair values of the forward contracts in Other income (expense), net. Refer to Note 8. Changes in fair value of our common stock option and common stock warrant holdings of our available for sale investments are recognized in either Other income (expense), net, or Other comprehensive loss, net. Refer to Note 7. </font></p>
</us-gaap:DerivativesPolicyTextBlock>
<!-- End Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table9 --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table10 -->
<us-gaap:GuaranteesIndemnificationsAndWarrantiesPolicies contextRef="Jan-01-2012_Sep-30-2012">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table10 - us-gaap:GuaranteesIndemnificationsAndWarrantiesPolicies--> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Product warranties</i>. Product warranty expense is recorded concurrently with the recording of revenue for product sales. The costs of warranties are accounted for as a component of cost of sales. We estimate warranty costs based on our estimated historical experience and adjust for any known product reliability issues. </font></p>
</us-gaap:GuaranteesIndemnificationsAndWarrantiesPolicies>
<!-- End Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table10 --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table11 -->
<opk:AllowanceForDoubtfulAccountsPolicyTextBlock contextRef="Jan-01-2012_Sep-30-2012" xmlns:opk="http://opko.com/20120930">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table11 - opk:AllowanceForDoubtfulAccountsPolicyTextBlock--> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Allowance for doubtful accounts</i>. We analyze accounts receivable and historical bad debt levels, customer credit worthiness and current economic trends when evaluating the adequacy of the allowance for doubtful accounts using the specific identification method. Our reported net loss is directly affected by our estimate of the collectability of accounts receivable. The amount of allowance for doubtful accounts was $0.3 million and $0.4 million at September 30, 2012 and December 31, 2011, respectively. </font></p>
</opk:AllowanceForDoubtfulAccountsPolicyTextBlock>
<!-- End Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table11 --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table12 -->
<us-gaap:SegmentReportingPolicyPolicyTextBlock contextRef="Jan-01-2012_Sep-30-2012">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table12 - us-gaap:SegmentReportingPolicyPolicyTextBlock--> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Segment reporting</i>. Our chief operating decision-maker (“CODM”) is comprised of our executive management team with the oversight of our Board of Directors. Our CODM reviews our operating results and operating plans and makes resource allocation decisions on a Company-wide or aggregate basis. We currently manage our operations in one reportable segment, pharmaceuticals. The pharmaceutical segment consists of two operating segments, our (i) pharmaceutical research and development segment which is focused on the research and development of pharmaceutical products, diagnostic tests and vaccines, and (ii) the pharmaceutical operations we acquired in Chile, Mexico, Israel and Spain through the acquisition of OPKO Chile S.A. (“OPKO Chile”), Exakta-OPKO S.A. de C.V (“Exakta-OPKO”), FineTech Pharmaceuticals Ltd. (“FineTech”) and Farmadiet Group Holding, S.L. (“Farmadiet”), respectively. We evaluate the performance of each operating segment based on operating profit or loss. There is no inter-segment allocation of interest expense and income taxes. </font></p>
</us-gaap:SegmentReportingPolicyPolicyTextBlock>
<!-- End Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table12 --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table13 -->
<us-gaap:CompensationRelatedCostsPolicyTextBlock contextRef="Jan-01-2012_Sep-30-2012">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table13 - us-gaap:CompensationRelatedCostsPolicyTextBlock--> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Equity-based compensation. </i>We measure the cost of employee services received in exchange for an award of equity instruments based on the grant-date fair value of the award. That cost is recognized in the statement of operations over the period during which an employee is required to provide service in exchange for the award. We record excess tax benefits, realized from the exercise of stock options as a financing cash inflow rather than as a reduction of taxes paid in cash flow from operations. Equity-based compensation arrangements to non-employees are recorded at their fair value on the measurement date. The measurement of equity-based compensation is subject to periodic adjustment as the underlying equity instruments vest. During the three months ended September 30, 2012 and 2011, we recorded $1.1 million and $1.8 million, respectively, of equity-based compensation expense. For the nine months ended September 30, 2012 and 2011, we recorded $3.3 million and $5.4 million, respectively, of equity-based compensation expense. </font></p>
</us-gaap:CompensationRelatedCostsPolicyTextBlock>
<!-- End Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table13 --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table14 -->
<us-gaap:NewAccountingPronouncementsPolicyPolicyTextBlock contextRef="Jan-01-2012_Sep-30-2012">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table14 - us-gaap:NewAccountingPronouncementsPolicyPolicyTextBlock--> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2"><i>Recent accounting pronouncements. </i>On January 1, 2012, we adopted an amendment issued by the Financial Accounting Standards Board (“FASB”) to the accounting standards related to fair value measurements and disclosure requirements. This amendment revises the existing guidance on the use and application of fair value measurements and maintains a definition of fair value that is based on the notion of exit price. The adoption of this amendment did not have a material impact on our condensed consolidated financial statements. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">On January 1, 2012, we adopted amendments issued by the FASB to the accounting standards related to the presentation of comprehensive income. These amendments revise the manner in which entities present comprehensive income in their financial statements and remove the option to present items of other comprehensive income in the statement of changes in stockholders’ equity. These amendments require an entity to report components of comprehensive income in either (1) a continuous statement of comprehensive income, or (2) two separate but consecutive statements of net income and other comprehensive income. We modified our condensed consolidated financial statements presentation using the latter alternative. </font></p> <p style="margin-top:12px;margin-bottom:0px; text-indent:4%"><font style="font-family:times new roman" size="2">On January 1, 2012, we adopted revised guidance issued by the FASB related to the testing of goodwill for impairment. Under the revised guidance, an entity has the option to perform a qualitative assessment of whether it is more-likely-than-not that a reporting unit’s fair value is less than its carrying value prior to performing the two-step quantitative goodwill impairment test. If, based on the qualitative factors, an entity determines that the fair value of the reporting unit is greater than its carrying amount, then the entity would not be required to perform the two-step quantitative impairment test for that reporting unit. However, if the qualitative assessment indicates that it is not more-likely-than-not that the reporting unit’s fair value exceeds its carrying value, then the quantitative assessment must be performed. An entity is permitted to perform the qualitative assessment on none, some or all of its reporting units and may also elect to bypass the qualitative assessment and begin with the quantitative assessment of goodwill impairment. This amendment did not have a material impact on our condensed consolidated financial statements. </font></p>
</us-gaap:NewAccountingPronouncementsPolicyPolicyTextBlock>
<!-- End Block Tagged Accounting Policy: opk-20120930_note2_accounting_policy_table14 --> <!-- Begin Block Tagged Note Table: opk-20120930_note4_table1 -->
<opk:CompositionOfCertainFinancialStatementCaptionsTableTextBlock contextRef="Jan-01-2012_Sep-30-2012" xmlns:opk="http://opko.com/20120930">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Note Table: opk-20120930_note4_table1 - opk:CompositionOfCertainFinancialStatementCaptionsTableTextBlock--> <table cellspacing="0" cellpadding="0" width="100%" border="0" style="border-collapse:collapse; text-align: left" align="center"> <!-- Begin Table Head --> <tr> <td width="82%"> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td valign="bottom" nowrap="nowrap"> <p style="border-bottom:1px solid #000000;width:45pt"><font style="font-family:times new roman" size="1">(In thousands)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">September 30,<br />2012<br />(unaudited)</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">December 31,<br />2011<br />(audited)</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <!-- End Table Head --> <!-- Begin Table Body --> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Accounts receivable, net</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Accounts receivable</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">19,490</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">12,984</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Less: allowance for doubtful accounts</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(348</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(440</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr> <td valign="top"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">19,142</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">12,544</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Inventories, net</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Finished products</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">17,750</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">11,100</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Work-in process</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">633</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">277</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Raw materials</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">4,513</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,287</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Less: reserve for obsolescence</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(1,408</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(325</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr> <td valign="top"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">21,488</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">13,339</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Intangible assets, net</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Customer relationships</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">19,232</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">18,386</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">In-process research and development</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">11,504</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">10,000</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Technology</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">50,211</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">47,100</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Product registrations</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">9,638</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">3,895</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Tradename</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,921</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">827</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Covenants not to compete</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,758</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,560</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Other</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">297</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">297</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Less: accumulated amortization</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(11,975</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(5,335</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr> <td valign="top"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">82,586</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">76,730</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Accrued expenses</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Income taxes payable</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">649</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">484</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Deferred revenue</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">955</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">530</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Clinical trials</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">58</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">7</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Professional fees</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">817</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">632</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Employee benefits</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,910</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">907</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Deferred acquisition payments, net of discount</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">5,983</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Contingent consideration</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">7,992</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Other</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">3,430</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,396</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr> <td valign="top"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">21,794</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">4,956</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Other long-term liabilities</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Contingent consideration</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">13,909</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">18,002</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Deferred acquisition payments, net of discount</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">3,769</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Deferred tax liabilities</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">10,845</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">6,863</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-top:0px;margin-bottom:1px; margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Long-term debt</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">3,954</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Other including deferred revenue</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">453</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">578</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">32,930</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">25,443</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <!-- End Table Body --> </table>
</opk:CompositionOfCertainFinancialStatementCaptionsTableTextBlock>
<!-- End Block Tagged Note Table: opk-20120930_note4_table1 --> <!-- Begin Block Tagged Note Table: opk-20120930_note5_table1 -->
<us-gaap:BusinessCombinationSeparatelyRecognizedTransactionsTableTextBlock contextRef="Jan-01-2012_Sep-30-2012_Arama_Laboratories_Acquisition_Member">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Note Table: opk-20120930_note5_table1 - us-gaap:BusinessCombinationSeparatelyRecognizedTransactionsTableTextBlock--> <table cellspacing="0" cellpadding="0" width="68%" border="0" style="border-collapse:collapse; text-align: left" align="center"> <!-- Begin Table Head --> <tr> <td width="88%"> </td> <td valign="bottom" width="6%"> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td valign="bottom" nowrap="nowrap"> <p style="border-bottom:1px solid #000000;width:45pt"><font style="font-family:times new roman" size="1">(In thousands)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td colspan="2" valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <!-- End Table Head --> <!-- Begin Table Body --> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Current assets (includes cash of $230)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">9,134</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Intangible assets:</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Customer relationships</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">436</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Technology</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">5,437</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">In-process research and development</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,459</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Product registrations</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">5,230</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Covenants not to compete</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">187</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Tradename</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,029</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:5.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total intangible assets</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">13,778</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Goodwill</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">8,520</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Plant and equipment</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">7,229</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Other assets</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">611</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Accounts payable and accrued expenses</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(3,667</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Deferred tax liability</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(3,169</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Deferred payment</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(7,755</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Debt assumed</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(7,829</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Contingent consideration</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(1,197</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total purchase price</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">15,655</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <!-- End Table Body --> </table>
</us-gaap:BusinessCombinationSeparatelyRecognizedTransactionsTableTextBlock>
<!-- End Block Tagged Note Table: opk-20120930_note5_table1 --> <!-- Begin Block Tagged Note Table: opk-20120930_note5_table2 -->
<us-gaap:BusinessCombinationSeparatelyRecognizedTransactionsTableTextBlock contextRef="Jan-01-2012_Sep-30-2012_Finetech_Acquisition_Member">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Note Table: opk-20120930_note5_table2 - us-gaap:BusinessCombinationSeparatelyRecognizedTransactionsTableTextBlock--> <table cellspacing="0" cellpadding="0" width="68%" border="0" style="border-collapse:collapse; text-align: left" align="center"> <!-- Begin Table Head --> <tr> <td width="88%"> </td> <td valign="bottom" width="6%"> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td valign="bottom" nowrap="nowrap"> <p style="border-bottom:1px solid #000000;width:45pt"><font style="font-family:times new roman" size="1">(In thousands)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td colspan="2" valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <!-- End Table Head --> <!-- Begin Table Body --> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Current assets (including cash of $2,000)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">3,358</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Intangible assets:</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Customer relationships</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">14,200</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Technology</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,700</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Covenants not to compete</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,500</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Tradename</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">400</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:5.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total intangible assets</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">18,800</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Goodwill</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">11,623</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Plant and equipment</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,358</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Other assets</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,154</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Accounts payable and accrued expenses</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(910</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Deferred tax liability</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(2,457</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Contingent consideration</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(4,747</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total purchase price</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">28,179</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <!-- End Table Body --> </table>
</us-gaap:BusinessCombinationSeparatelyRecognizedTransactionsTableTextBlock>
<!-- End Block Tagged Note Table: opk-20120930_note5_table2 --> <!-- Begin Block Tagged Note Table: opk-20120930_note5_table3 -->
<us-gaap:BusinessCombinationSeparatelyRecognizedTransactionsTableTextBlock contextRef="Jan-01-2012_Sep-30-2012_Claros_Diagnostics_Member">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Note Table: opk-20120930_note5_table3 - us-gaap:BusinessCombinationSeparatelyRecognizedTransactionsTableTextBlock--> <table cellspacing="0" cellpadding="0" width="68%" border="0" style="border-collapse:collapse; text-align: left" align="center"> <!-- Begin Table Head --> <tr> <td width="87%"> </td> <td valign="bottom" width="7%"> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td valign="bottom" nowrap="nowrap"> <p style="border-bottom:1px solid #000000;width:45pt"><font style="font-family:times new roman" size="1">(In thousands)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td colspan="2" valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <!-- End Table Head --> <!-- Begin Table Body --> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Current assets (including cash of $351)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">378</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Technology</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">44,400</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Goodwill</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">17,977</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Equipment</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">333</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Other assets</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">18</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Accounts payable and accrued expenses</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(655</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Deferred tax liability</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(17,254</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Contingent consideration</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(12,745</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total purchase price</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">32,452</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <!-- End Table Body --> </table>
</us-gaap:BusinessCombinationSeparatelyRecognizedTransactionsTableTextBlock>
<!-- End Block Tagged Note Table: opk-20120930_note5_table3 --> <!-- Begin Block Tagged Note Table: opk-20120930_note5_table4 -->
<us-gaap:InvestmentIncomeTextBlock contextRef="Jan-01-2012_Sep-30-2012">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Note Table: opk-20120930_note5_table4 - us-gaap:InvestmentIncomeTextBlock--> <table cellspacing="0" cellpadding="0" width="100%" border="0" style="border-collapse:collapse; text-align: left" align="center"> <!-- Begin Table Head --> <tr> <td width="28%"> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="4%"> </td> <td width="38%"> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td valign="bottom" nowrap="nowrap"> <p style="margin-top:0px;margin-bottom:0px"><font style="font-family:times new roman" size="1">(Dollars in thousands)</font></p> <p style="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000;width:70pt"><font style="font-family:times new roman" size="1"> Investee Name</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1"><b></b><b></b><b></b><b></b>Year Acquired</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" style="border-bottom:1px solid #000000"> <p style="margin-top:0px;margin-bottom:1px"><font style="font-family:times new roman" size="1"><b></b><b></b><b></b><b></b><b></b><b></b>Accounting Method</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Ownership<br />September 30,<br />2012</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1"><b></b><b></b>Investment</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1"><b></b><b></b>Underlying<br />equity in net<br />assets</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <!-- End Table Head --> <!-- Begin Table Body --> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Sorrento</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2009</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">Equity method</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">19</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">% </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,300</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,596</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Cocrystal</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2009</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">Equity method</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">16</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">% </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,500</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,012</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Neovasc</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2011</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">Equity method, cost (warrants)</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">4</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">% </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,013</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">146</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Fabrus</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2010</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">VIE, equity method</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">13</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">% </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">650</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">53</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">BZNE common stock</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2012</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">VIE, equity method</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">12</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">% </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,276</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(9</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr> <td valign="top" colspan="7"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Less: accumulated losses in investees</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(4,115</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top" colspan="7"> <p style="margin-left:5.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total carrying value of equity method investees</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">4,624</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">BZNE Note and conversion feature</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2012</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">VIE, investment available for sale</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">N/A</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,700</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">ChromaDex</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2012</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">Investment, available for sale</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">% </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,000</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Neovasc options</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2011</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">Investment, available for sale</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">N/A</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">925</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">TESARO</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2010</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">Investment, available for sale</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">% </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">731</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top" colspan="7"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Plus: unrealized gains on investments, options and warrants, net</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">6,018</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top" colspan="7"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total carrying value of investments, available for sale</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">10,374</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">14,998</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <!-- End Table Body --> </table>
</us-gaap:InvestmentIncomeTextBlock>
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<opk:DisposalGroupIncludingDiscontinuedOperationClassifiedBalanceSheetDisclosuresTableTextBlock contextRef="Jan-01-2012_Sep-30-2012" xmlns:opk="http://opko.com/20120930">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Note Table: opk-20120930_note6_table1 - opk:DisposalGroupIncludingDiscontinuedOperationClassifiedBalanceSheetDisclosuresTableTextBlock--> <table cellspacing="0" cellpadding="0" width="76%" border="0" style="border-collapse:collapse; text-align: left" align="center"> <!-- Begin Table Head --> <tr> <td width="74%"> </td> <td valign="bottom" width="10%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="10%"> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td valign="bottom" nowrap="nowrap"><font style="font-family:times new roman" size="1">(In thousands)</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">September 30,</font><br /><font style="font-family:times new roman" size="1">2012</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">December 31,</font><br /><font style="font-family:times new roman" size="1">2011</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <!-- End Table Head --> <!-- Begin Table Body --> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Assets:</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Other current assets</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">4</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total assets of discontinued operations</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">4</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Liabilities:</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Trade accounts payable</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Accrued expenses and other liabilities</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">173</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total liabilities of discontinued operations</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">174</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <!-- End Table Body --> </table>
</opk:DisposalGroupIncludingDiscontinuedOperationClassifiedBalanceSheetDisclosuresTableTextBlock>
<!-- End Block Tagged Note Table: opk-20120930_note6_table1 --> <!-- Begin Block Tagged Note Table: opk-20120930_note6_table2 -->
<opk:DisposalGroupNotDiscontinuedOperationIncomeStatementDisclosuresTableTextBlock contextRef="Jan-01-2012_Sep-30-2012" xmlns:opk="http://opko.com/20120930">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Note Table: opk-20120930_note6_table2 - opk:DisposalGroupNotDiscontinuedOperationIncomeStatementDisclosuresTableTextBlock--> <table cellspacing="0" cellpadding="0" width="92%" border="0" style="border-collapse:collapse; text-align: left" align="center"> <!-- Begin Table Head --> <tr> <td width="72%"> </td> <td valign="bottom" width="3%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="3%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="3%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="3%"> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="6" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">For the three months  ended</font><br /><font style="font-family:times new roman" size="1">September 30,</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="6" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">For the nine months  ended</font><br /><font style="font-family:times new roman" size="1">September 30,</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <tr> <td valign="bottom" nowrap="nowrap"> <p style="border-bottom:1px solid #000000;width:45pt"><font style="font-family:times new roman" size="1">(In thousands)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">2012</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">2011</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">2012</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">2011</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <!-- End Table Head --> <!-- Begin Table Body --> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total revenue</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">730</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">4,142</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Operating income (loss) </font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">183</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(1,481</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">183</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(2,819</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Income (loss) before provision for income taxes</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">183</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(1,487</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">183</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(2,841</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Net income (loss)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">183</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(1,487</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">183</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(2,841</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <!-- End Table Body --> </table>
</opk:DisposalGroupNotDiscontinuedOperationIncomeStatementDisclosuresTableTextBlock>
<!-- End Block Tagged Note Table: opk-20120930_note6_table2 --> <!-- Begin Block Tagged Note Table: opk-20120930_note7_table1 -->
<us-gaap:TradingSecuritiesAndCertainTradingAssetsTextBlock contextRef="Jan-01-2012_Sep-30-2012">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Note Table: opk-20120930_note7_table1 - us-gaap:TradingSecuritiesAndCertainTradingAssetsTextBlock--> <table cellspacing="0" cellpadding="0" width="100%" border="0" style="border-collapse:collapse; text-align: left" align="center"> <!-- Begin Table Head --> <tr> <td width="63%"> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td valign="bottom" nowrap="nowrap"> <p style="border-bottom:1px solid #000000;width:45pt"><font style="font-family:times new roman" size="1">(In thousands)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Amortized</font><br /><font style="font-family:times new roman" size="1">cost</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Gross</font><br /><font style="font-family:times new roman" size="1">unrealized</font><br /><font style="font-family:times new roman" size="1"> gains in</font><br /><font style="font-family:times new roman" size="1">Accumulated</font><br /><font style="font-family:times new roman" size="1">OCI</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Gross</font><br /><font style="font-family:times new roman" size="1">unrealized</font><br /><font style="font-family:times new roman" size="1"> losses in</font><br /><font style="font-family:times new roman" size="1">Accumulated<br />OCI</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Gain/(Loss)</font><br /><font style="font-family:times new roman" size="1">in</font><br /><font style="font-family:times new roman" size="1"> Accumulated</font><br /><font style="font-family:times new roman" size="1">Deficit</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Fair</font><br /><font style="font-family:times new roman" size="1">Value</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <!-- End Table Head --> <!-- Begin Table Body --> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Common stock investments</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,731</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">5,407</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">7,138</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">BZNE Note and conversion feature</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,700</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">53</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">287</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,040</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Neovasc common stock options</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">925</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">249</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">119</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,293</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Neovasc common stock warrants</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">659</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">194</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(375</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">478</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total assets</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">5,015</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">5,903</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">31</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">10,949</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <!-- End Table Body --> </table>
</us-gaap:TradingSecuritiesAndCertainTradingAssetsTextBlock>
<!-- End Block Tagged Note Table: opk-20120930_note7_table1 --> <!-- Begin Block Tagged Note Table: opk-20120930_note7_table2 -->
<us-gaap:ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock contextRef="Jan-01-2012_Sep-30-2012">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Note Table: opk-20120930_note7_table2 - us-gaap:ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock--> <table cellspacing="0" cellpadding="0" width="92%" border="0" style="border-collapse:collapse; text-align: left" align="center"> <!-- Begin Table Head --> <tr> <td width="64%"> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="4%"> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="14" nowrap="nowrap" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Fair value measurements as of September 30, 2012</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <tr> <td valign="bottom" nowrap="nowrap"> <p style="border-bottom:1px solid #000000;width:45pt"><font style="font-family:times new roman" size="1">(In thousands)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Quote prices<br />in active<br />markets for<br />identical</font><br /><font style="font-family:times new roman" size="1"> assets</font><br /><font style="font-family:times new roman" size="1">(Level 1)</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Significant<br />other</font><br /><font style="font-family:times new roman" size="1">observable<br />inputs</font><br /> <font style="font-family:times new roman" size="1">(Level 2)</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Significant</font><br /><font style="font-family:times new roman" size="1">unobservable<br />inputs</font><br /><font style="font-family:times new roman" size="1"> (Level 3)</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Total</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <!-- End Table Head --> <!-- Begin Table Body --> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Assets:</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Money market funds</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">14,505</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">14,505</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">US Treasury securities</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">14,997</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">14,997</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Certificates of deposit</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">10,423</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">10,423</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Forward contracts</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">59</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">59</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Common stock investments</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">7,138</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">7,138</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">BZNE Note and conversion feature</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,040</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,040</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Neovasc common stock options</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,293</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,293</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Neovasc common stock warrants</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">478</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">478</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total assets</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">36,640</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">12,253</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,040</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">50,933</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Liabilities:</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Deferred acquisition payments, net of discount</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">9,752</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">9,752</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">CURNA contingent consideration</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">510</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">510</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">OPKO Diagnostics contingent consideration</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">15,098</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">15,098</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">FineTech contingent consideration</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">5,042</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">5,042</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Farmadiet contingent consideration</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,251</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,251</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total liabilities</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">31,653</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">31,653</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <!-- End Table Body --> </table>
</us-gaap:ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock>
<!-- End Block Tagged Note Table: opk-20120930_note7_table2 --> <!-- Begin Block Tagged Note Table: opk-20120930_note7_table3 -->
<opk:ReconcilesBeginningAndEndingBalancesOfLevelThreeAssetsAndLiabilitiesTableTextBlock contextRef="Jan-01-2012_Sep-30-2012" xmlns:opk="http://opko.com/20120930">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Note Table: opk-20120930_note7_table3 - opk:ReconcilesBeginningAndEndingBalancesOfLevelThreeAssetsAndLiabilitiesTableTextBlock--> <table cellspacing="0" cellpadding="0" width="76%" border="0" style="border-collapse:collapse; text-align: left" align="center"> <!-- Begin Table Head --> <tr> <td width="64%"> </td> <td valign="bottom" width="7%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="7%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="7%"> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td valign="bottom" nowrap="nowrap"> <p style="border-bottom:1px solid #000000;width:45pt"><font style="font-family:times new roman" size="1">(In thousands)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">BZNE<br />Note and<br />conversion<br />feature</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Contingent<br />consideration</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Deferred<br />acquisition<br />payments,<br />net of discount</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <!-- End Table Head --> <!-- Begin Table Body --> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Balance at December 31, 2011</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">18,002</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Additions</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,700</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,234</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">9,673</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Change in fair value included in:</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:5.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Operating expenses</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,665</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:5.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Other income and (expense), net</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,563</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">79</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:5.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Other comprehensive loss</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font><br /></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">53</font><br /></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font><br /></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Transfer out to equity method investment</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(1,276</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Balance at September 30, 2012</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,040</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">21,901</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">9,752</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <!-- End Table Body --> </table>
</opk:ReconcilesBeginningAndEndingBalancesOfLevelThreeAssetsAndLiabilitiesTableTextBlock>
<!-- End Block Tagged Note Table: opk-20120930_note7_table3 --> <!-- Begin Block Tagged Note Table: opk-20120930_note8_table1 -->
<us-gaap:ScheduleOfForeignExchangeContractsStatementOfFinancialPositionTableTextBlock contextRef="Jan-01-2012_Sep-30-2012">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Note Table: opk-20120930_note8_table1 - us-gaap:ScheduleOfForeignExchangeContractsStatementOfFinancialPositionTableTextBlock--> <table cellspacing="0" cellpadding="0" width="84%" border="0" style="border-collapse:collapse; text-align: left" align="center"> <!-- Begin Table Head --> <tr> <td width="60%"> </td> <td valign="bottom" width="10%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="10%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="10%"> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td valign="bottom" nowrap="nowrap"> <p style="border-bottom:1px solid #000000;width:62pt"><font style="font-family:times new roman" size="1">Days until maturity</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Contract value</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Fair value at</font><br /><font style="font-family:times new roman" size="1">September 30,  2012</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">Effect on loss</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <!-- End Table Head --> <!-- Begin Table Body --> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">0 to 30</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,798</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,834</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(36</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">31 to 60</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,273</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,288</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(15</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">61 to 90</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">320</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">328</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(8</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">91 to 120</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">121 to 180</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">More than 180</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Total</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">3,391</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">3,450</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(59</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <!-- End Table Body --> </table>
</us-gaap:ScheduleOfForeignExchangeContractsStatementOfFinancialPositionTableTextBlock>
<!-- End Block Tagged Note Table: opk-20120930_note8_table1 --> <!-- Begin Block Tagged Note Table: opk-20120930_note11_table1 -->
<opk:ScheduleOfInformationRegardingProductRevenueByGeographicAreaTableTextBlock contextRef="Jan-01-2012_Sep-30-2012" xmlns:opk="http://opko.com/20120930">
<!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --> <!-- Begin Block Tagged Note Table: opk-20120930_note11_table1 - opk:ScheduleOfInformationRegardingProductRevenueByGeographicAreaTableTextBlock--> <table cellspacing="0" cellpadding="0" width="92%" border="0" style="border-collapse:collapse; text-align: left" align="center"> <!-- Begin Table Head --> <tr> <td width="66%"> </td> <td valign="bottom" width="3%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="3%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="3%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="3%"> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td valign="bottom"> <font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="6" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">For three months ended<br />September 30,</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="6" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">For the nine months ended<br />September 30,</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <tr> <td valign="bottom" nowrap="nowrap"> <p style="border-bottom:1px solid #000000;width:45pt"><font style="font-family:times new roman" size="1">(In thousands)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">2012</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">2011</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">2012</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">2011</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <!-- End Table Head --> <!-- Begin Table Body --> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Operating loss from continuing operations</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Pharmaceutical</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(5,593</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(262</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(17,053</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(3,601</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Corporate</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(3,776</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(5,542</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(10,504</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(11,113</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr> <td valign="top"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(9,369</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(5,804</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(27,557</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">(14,714</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2">) </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Depreciation and amortization</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Pharmaceutical</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,618</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">997</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">7,315</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,731</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Corporate</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">44</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">43</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">132</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">127</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr> <td valign="top"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,662</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,040</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">7,447</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">2,858</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Product sales</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">United States</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Chile</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">6,781</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">5,356</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">19,669</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">17,545</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Spain</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,997</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,997</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Israel</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,516</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">4,661</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Mexico</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,201</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">1,404</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">3,724</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">4,568</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">11,495</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">6,760</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">30,051</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">22,113</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <!-- End Table Body --> </table> <p style="font-size:1px;margin-top:12px;margin-bottom:0px"> </p> <table cellspacing="0" cellpadding="0" width="76%" border="0" style="border-collapse:collapse; text-align: left" align="center"> <!-- Begin Table Head --> <tr> <td width="74%"> </td> <td valign="bottom" width="6%"> </td> <td> </td> <td> </td> <td> </td> <td valign="bottom" width="6%"> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="6" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">As of</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <tr> <td valign="bottom" nowrap="nowrap"> <p style="border-bottom:1px solid #000000;width:45pt"><font style="font-family:times new roman" size="1">(In thousands)</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">September 30,<br />2012</font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom" colspan="2" align="center" style="border-bottom:1px solid #000000"><font style="font-family:times new roman" size="1">December 31,<br />2011</font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <!-- End Table Head --> <!-- Begin Table Body --> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:1.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Assets:</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> </td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Pharmaceutical</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">198,483</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">154,437</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Corporate</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">51,539</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">75,048</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr> <td valign="top"> <p style="margin-left:3.00em; text-indent:-1.00em"><font style="font-family:times new roman" size="2">Discontinued operations</font></p> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">—  </font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">4</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td valign="bottom"> <p style="border-top:1px solid #000000"> </p> </td> <td> </td> </tr> <tr bgcolor="#cceeff"> <td valign="top"> </td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">250,022</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="font-family:times new roman" size="2">$</font></td> <td valign="bottom" align="right"><font style="font-family:times new roman" size="2">229,489</font></td> <td nowrap="nowrap" valign="bottom"><font style="font-family:times new roman" size="2"> </font></td> </tr> <tr style="font-size:1px"> <td valign="bottom"> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> <td valign="bottom"> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td valign="bottom"> <p style="border-top:3px double #000000"> </p> </td> <td> </td> </tr> <!-- End Table Body --> </table>
</opk:ScheduleOfInformationRegardingProductRevenueByGeographicAreaTableTextBlock>
<!-- End Block Tagged Note Table: opk-20120930_note11_table1 -->
<dei:AmendmentFlag contextRef="Jan-01-2012_Sep-30-2012"> false </dei:AmendmentFlag>
<dei:CurrentFiscalYearEndDate contextRef="Jan-01-2012_Sep-30-2012"> --12-31 </dei:CurrentFiscalYearEndDate>
<dei:DocumentFiscalPeriodFocus contextRef="Jan-01-2012_Sep-30-2012"> Q3 </dei:DocumentFiscalPeriodFocus>
<dei:DocumentFiscalYearFocus contextRef="Jan-01-2012_Sep-30-2012"> 2012 </dei:DocumentFiscalYearFocus>
<dei:DocumentPeriodEndDate contextRef="Jan-01-2012_Sep-30-2012"> 2012-09-30 </dei:DocumentPeriodEndDate>
<dei:DocumentType contextRef="Jan-01-2012_Sep-30-2012"> 10-Q </dei:DocumentType>
<dei:EntityCentralIndexKey contextRef="Jan-01-2012_Sep-30-2012"> 0000944809 </dei:EntityCentralIndexKey>
<dei:EntityCommonStockSharesOutstanding contextRef="BalanceAsOf_02Nov2012" unitRef="Shares" decimals="INF"> 298184058 </dei:EntityCommonStockSharesOutstanding>
<dei:EntityFilerCategory contextRef="Jan-01-2012_Sep-30-2012"> Accelerated Filer </dei:EntityFilerCategory>
<dei:EntityRegistrantName contextRef="Jan-01-2012_Sep-30-2012"> Opko Health, Inc. </dei:EntityRegistrantName>
<opk:AccountsReceivableFromMajorCustomer contextRef="BalanceAsOf_31Dec2011_Customer_One_Member" unitRef="Pure" decimals="2"> 0.29 </opk:AccountsReceivableFromMajorCustomer>
<opk:AccountsReceivableFromMajorCustomer contextRef="BalanceAsOf_30Sep2012" unitRef="Pure" decimals="2"> 0.1 </opk:AccountsReceivableFromMajorCustomer>
<opk:AccruedClinicalTrials contextRef="BalanceAsOf_31Dec2011" unitRef="USD" decimals="-3"> 7000 </opk:AccruedClinicalTrials>
<opk:AccruedClinicalTrials contextRef="BalanceAsOf_30Sep2012" unitRef="USD" decimals="-3"> 58000 </opk:AccruedClinicalTrials>
<opk:AdditionalAgreementToLeaseSpaceToHouseManufacturing contextRef="BalanceAsOf_01Jul2011" unitRef="Square_Foot" decimals="INF"> 5000 </opk:AdditionalAgreementToLeaseSpaceToHouseManufacturing>
<opk:AdditionalAmountPaidForLegalRegistration contextRef="BalanceAsOf_30Apr2012_Als_Acquisition_Member" unitRef="USD" decimals="-5"> 4000000 </opk:AdditionalAmountPaidForLegalRegistration>
<opk:AdditionalInvestmentByGroupOfInvestor contextRef="BalanceAsOf_21Sep2009" unitRef="USD" decimals="-6"> 5000000 </opk:AdditionalInvestmentByGroupOfInvestor>
<opk:AdditionalTermOfUseOfSpaceToHouseMolecularDiagnosticsOperations contextRef="BalanceAsOf_20Jul2010_Trsi_Member"> P1Y </opk:AdditionalTermOfUseOfSpaceToHouseMolecularDiagnosticsOperations>
<opk:AdditionsToReconciliationOfFairValueMeasurement contextRef="NineMonthsEnded_30Sep2012_Bnze_Note_And_Bnze_Warrants_Member" unitRef="USD" decimals="-3"> 1700000 </opk:AdditionsToReconciliationOfFairValueMeasurement>
<opk:AdditionsToReconciliationOfFairValueMeasurement contextRef="NineMonthsEnded_30Sep2012_Contingent_Consideration_Member" unitRef="USD" decimals="-3"> 1234000 </opk:AdditionsToReconciliationOfFairValueMeasurement>
<opk:AdditionsToReconciliationOfFairValueMeasurement contextRef="NineMonthsEnded_30Sep2012_Deferred_Acquisition_Payments_Net_Of_Discount_Member" unitRef="USD" decimals="-3"> 9673000 </opk:AdditionsToReconciliationOfFairValueMeasurement>
<opk:AgreementPursuantToWhichInvested contextRef="BalanceAsOf_21Sep2009" unitRef="USD" decimals="-5"> 2500000 </opk:AgreementPursuantToWhichInvested>
<opk:AgreementToLeaseSpaceToHouseManufacturing contextRef="BalanceAsOf_16Jun2009" unitRef="Square_Foot" decimals="INF"> 10000 </opk:AgreementToLeaseSpaceToHouseManufacturing>
<opk:AmountPayableOnCashOrSharesOnAchievingMilestones contextRef="BalanceAsOf_31Aug2012_Product_In_Development_Member_Farmadiet_Acquisition_Member" unitRef="USD" decimals="-5"> 800000 </opk:AmountPayableOnCashOrSharesOnAchievingMilestones>
<opk:AncillaryTransactionDetails contextRef="BalanceAsOf_31Aug2012_Farmadiet_Acquisition_Member"> In connection with the Transaction, we also entered into two ancillary transactions (the “Ancillary Transactions”). In exchange for a forty percent interest held by one of the Sellers in one of Farmadiet’s subsidiaries </opk:AncillaryTransactionDetails>
<opk:AreaForMolecularDiagnosticsOperations contextRef="BalanceAsOf_20Jul2010_Trsi_Member" unitRef="Square_Foot" decimals="INF"> 1100 </opk:AreaForMolecularDiagnosticsOperations>
<opk:AverageClosingSalesPricePerShareOfCommonStock contextRef="OneMonthEnded_31Oct2011_Claros_Diagnostics_Member" unitRef="USDEPS" decimals="2"> 4.45 </opk:AverageClosingSalesPricePerShareOfCommonStock>
<opk:AverageClosingSalesPricePerShareOfCommonStock contextRef="OneMonthEnded_31Dec2011" unitRef="USDEPS" decimals="2"> 4.84 </opk:AverageClosingSalesPricePerShareOfCommonStock>
<opk:BiozonePharmaceuticalsWarrantsExercised contextRef="BalanceAsOf_31Jul2012_Biozone_Pharmaceuticals_Inc_Member" unitRef="Shares" decimals="INF"> 7650000 </opk:BiozonePharmaceuticalsWarrantsExercised>
<opk:BusinessAcquisitionCostOfAcquiredEntityCashPaidThroughEscrowAccount contextRef="BalanceAsOf_30Apr2012_Als_Acquisition_Member" unitRef="USD" decimals="-5"> 800000 </opk:BusinessAcquisitionCostOfAcquiredEntityCashPaidThroughEscrowAccount>
<opk:BusinessAcquisitionCostOfAcquiredEntityCommonStockIssuedMarketValuePerShare contextRef="BalanceAsOf_13Oct2011_Claros_Diagnostics_Member" unitRef="USDEPS" decimals="2"> 5.04 </opk:BusinessAcquisitionCostOfAcquiredEntityCommonStockIssuedMarketValuePerShare>
<opk:BusinessAcquisitionCostOfAcquiredEntityCommonStockIssuedMarketValuePerShare contextRef="BalanceAsOf_29Dec2011" unitRef="USDEPS" decimals="2"> 4.90 </opk:BusinessAcquisitionCostOfAcquiredEntityCommonStockIssuedMarketValuePerShare>
<opk:BusinessAcquisitionCostOfAcquiredEntityCommonStockIssuedMarketValuePerShare contextRef="BalanceAsOf_30Sep2012_Investments_Member_Sorrento_Therapeutics_Inc_Member" unitRef="USDEPS" decimals="2"> 0.25 </opk:BusinessAcquisitionCostOfAcquiredEntityCommonStockIssuedMarketValuePerShare>
<opk:BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuableParValue contextRef="BalanceAsOf_31Aug2011_Neovasc_Inc_Member" unitRef="USDEPS" decimals="2"> 1.25 </opk:BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuableParValue>
<opk:BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuableParValue contextRef="BalanceAsOf_29Feb2012_Biozone_Pharmaceuticals_Inc_Member" unitRef="USDEPS" decimals="2"> 0.20 </opk:BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuableParValue>
<opk:BusinessAcquisitionCostOfAcquiredEntityLiabilitiesIncurredPaidAtClosing contextRef="BalanceAsOf_28Jan2011" unitRef="USD" decimals="-5"> 500000 </opk:BusinessAcquisitionCostOfAcquiredEntityLiabilitiesIncurredPaidAtClosing>
<opk:BusinessAcquisitionPurchaseOfCommonStockShares contextRef="BalanceAsOf_31Aug2011_Neovasc_Inc_Member" unitRef="Shares" decimals="-6"> 2000000 </opk:BusinessAcquisitionPurchaseOfCommonStockShares>
<opk:BusinessAcquisitionPurchaseOfCommonStockShares contextRef="BalanceAsOf_29Feb2012_Chromadex_Corporation_Member" unitRef="Shares" decimals="INF"> 1333333 </opk:BusinessAcquisitionPurchaseOfCommonStockShares>
<opk:BusinessAcquisitionPurchaseOfSeriesPreferredStock contextRef="OneMonthEnded_30Sep2009_Cocrystal_Discovery_Inc_Member" unitRef="Shares" decimals="INF"> 1701723 </opk:BusinessAcquisitionPurchaseOfSeriesPreferredStock>
<opk:BusinessAcquisitionPurchasePriceAllocationCovenantsNotToCompete contextRef="BalanceAsOf_30Sep2012_Arama_Laboratories_Acquisition_Member" unitRef="USD" decimals="-3"> 187000 </opk:BusinessAcquisitionPurchasePriceAllocationCovenantsNotToCompete>
<opk:BusinessAcquisitionPurchasePriceAllocationCovenantsNotToCompete contextRef="BalanceAsOf_30Sep2012_Finetech_Acquisition_Member" unitRef="USD" decimals="-3"> 1500000 </opk:BusinessAcquisitionPurchasePriceAllocationCovenantsNotToCompete>
<opk:BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayableAndAccruedExpenses contextRef="BalanceAsOf_30Sep2012_Arama_Laboratories_Acquisition_Member" unitRef="USD" decimals="-3"> 3667000 </opk:BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayableAndAccruedExpenses>
<opk:BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayableAndAccruedExpenses contextRef="BalanceAsOf_30Sep2012_Claros_Diagnostics_Member" unitRef="USD" decimals="-3"> 655000 </opk:BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayableAndAccruedExpenses>
<opk:BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayableAndAccruedExpenses contextRef="BalanceAsOf_30Sep2012_Finetech_Acquisition_Member" unitRef="USD" decimals="-3"> 910000 </opk:BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayableAndAccruedExpenses>
<opk:BusinessAcquisitionPurchasePriceAllocationCustomerRelationships contextRef="BalanceAsOf_30Sep2012_Arama_Laboratories_Acquisition_Member" unitRef="USD" decimals="-3"> 436000 </opk:BusinessAcquisitionPurchasePriceAllocationCustomerRelationships>
<opk:BusinessAcquisitionPurchasePriceAllocationCustomerRelationships contextRef="BalanceAsOf_30Sep2012_Finetech_Acquisition_Member" unitRef="USD" decimals="-3"> 14200000 </opk:BusinessAcquisitionPurchasePriceAllocationCustomerRelationships>
<opk:BusinessAcquisitionPurchasePriceAllocationDeferredPayment contextRef="BalanceAsOf_30Sep2012_Arama_Laboratories_Acquisition_Member" unitRef="USD" decimals="-3"> -7755000 </opk:BusinessAcquisitionPurchasePriceAllocationDeferredPayment>
<opk:BusinessAcquisitionPurchasePriceAllocationProductRegistrations contextRef="BalanceAsOf_30Sep2012_Arama_Laboratories_Acquisition_Member" unitRef="USD" decimals="-3"> 5230000 </opk:BusinessAcquisitionPurchasePriceAllocationProductRegistrations>
<opk:BusinessAcquisitionPurchasePriceAllocationTechnology contextRef="BalanceAsOf_30Sep2012_Arama_Laboratories_Acquisition_Member" unitRef="USD" decimals="-3"> 5437000 </opk:BusinessAcquisitionPurchasePriceAllocationTechnology>
<opk:BusinessAcquisitionPurchasePriceAllocationTechnology contextRef="BalanceAsOf_30Sep2012_Claros_Diagnostics_Member" unitRef="USD" decimals="-3"> 44400000 </opk:BusinessAcquisitionPurchasePriceAllocationTechnology>
<opk:BusinessAcquisitionPurchasePriceAllocationTechnology contextRef="BalanceAsOf_30Sep2012_Finetech_Acquisition_Member" unitRef="USD" decimals="-3"> 2700000 </opk:BusinessAcquisitionPurchasePriceAllocationTechnology>
<opk:BusinessAcquisitionPurchasePriceAllocationTradeName contextRef="BalanceAsOf_30Sep2012_Arama_Laboratories_Acquisition_Member" unitRef="USD" decimals="-3"> 1029000 </opk:BusinessAcquisitionPurchasePriceAllocationTradeName>
<opk:BusinessAcquisitionPurchasePriceAllocationTradeName contextRef="BalanceAsOf_30Sep2012_Finetech_Acquisition_Member" unitRef="USD" decimals="-3"> 400000 </opk:BusinessAcquisitionPurchasePriceAllocationTradeName>
<opk:BusinessAcquisitionPurchasePriceInProcessResearchAndDevelopmentExpensed contextRef="BalanceAsOf_30Sep2012_Arama_Laboratories_Acquisition_Member" unitRef="USD" decimals="-3"> 1459000 </opk:BusinessAcquisitionPurchasePriceInProcessResearchAndDevelopmentExpensed>
<opk:ClaimAgainstEscrowForUndisclosedLiabilities contextRef="OneMonthEnded_31Dec2011_Claros_Diagnostics_Member" unitRef="USD" decimals="-5"> 200000 </opk:ClaimAgainstEscrowForUndisclosedLiabilities>
<opk:CommonStockIssuedForStockOptionAndWarrantsExercises contextRef="Jan-01-2012_Sep-30-2012" unitRef="Shares" decimals="INF"> 748783 </opk:CommonStockIssuedForStockOptionAndWarrantsExercises>
<opk:CommonStockWarrantsNetExercised contextRef="NineMonthsEnded_30Sep2011" unitRef="USD" decimals="-3"> 1155000 </opk:CommonStockWarrantsNetExercised>
<opk:CommonStockWarrantsNetExercised contextRef="Jan-01-2012_Sep-30-2012" unitRef="USD" decimals="-3"> 7000 </opk:CommonStockWarrantsNetExercised>
<opk:ContingentConsiderationLongTermObligations contextRef="BalanceAsOf_31Dec2011" unitRef="USD" decimals="-3"> 18002000 </opk:ContingentConsiderationLongTermObligations>
<opk:ContingentConsiderationLongTermObligations contextRef="BalanceAsOf_30Sep2012" unitRef="USD" decimals="-3"> 13909000 </opk:ContingentConsiderationLongTermObligations>
<opk:CreditForTenantImprovements contextRef="OneMonthEnded_30Nov2007_Real_Estate_Holdings_Llc_Member" unitRef="USD" decimals="-3"> 30000 </opk:CreditForTenantImprovements>
<opk:DeferredAcquisitionPaymentsDiscount contextRef="BalanceAsOf_31Aug2012_Farmadiet_Acquisition_Member" unitRef="USD" decimals="-5"> 600000 </opk:DeferredAcquisitionPaymentsDiscount>
<opk:DeferredAcquisitionPaymentsNetOfDiscount xsi:nil="true" contextRef="BalanceAsOf_31Dec2011" unitRef="USD"/>
<opk:DeferredAcquisitionPaymentsNetOfDiscount contextRef="BalanceAsOf_31Aug2012_Farmadiet_Acquisition_Member" unitRef="EUR" decimals="-5"> 6800000 </opk:DeferredAcquisitionPaymentsNetOfDiscount>
<opk:DeferredAcquisitionPaymentsNetOfDiscount contextRef="BalanceAsOf_31Aug2012_Farmadiet_Acquisition_Member" unitRef="USD" decimals="-5"> 7800000 </opk:DeferredAcquisitionPaymentsNetOfDiscount>
<opk:DeferredAcquisitionPaymentsNetOfDiscount contextRef="BalanceAsOf_30Sep2012" unitRef="USD" decimals="-3"> 5983000 </opk:DeferredAcquisitionPaymentsNetOfDiscount>
<opk:DeferredAcquisitionPaymentsNetOfDiscountLongTermLiabilities xsi:nil="true" contextRef="BalanceAsOf_31Dec2011" unitRef="USD"/>
<opk:DeferredAcquisitionPaymentsNetOfDiscountLongTermLiabilities contextRef="BalanceAsOf_30Sep2012" unitRef="USD" decimals="-3"> 3769000 </opk:DeferredAcquisitionPaymentsNetOfDiscountLongTermLiabilities>
<opk:DeferredPaymentToSatisfyIndemnityClaims contextRef="BalanceAsOf_31Aug2012_Farmadiet_Acquisition_Member" unitRef="USD" decimals="-5"> 3400000 </opk:DeferredPaymentToSatisfyIndemnityClaims>
<opk:DisposalGroupIncludingDiscontinuedOperationAccruedExpensesAndOtherLiabilities contextRef="BalanceAsOf_31Dec2011" unitRef="USD" decimals="-3"> 173000 </opk:DisposalGroupIncludingDiscontinuedOperationAccruedExpensesAndOtherLiabilities>
<opk:DisposalGroupIncludingDiscontinuedOperationAccruedExpensesAndOtherLiabilities contextRef="BalanceAsOf_30Sep2012" unitRef="USD" decimals="-3"> 1000 </opk:DisposalGroupIncludingDiscontinuedOperationAccruedExpensesAndOtherLiabilities>
<opk:DisposalGroupIncludingDiscontinuedOperationReceivedRoyalties contextRef="OneMonthEnded_31Oct2011" unitRef="USD" decimals="-5"> 22500000 </opk:DisposalGroupIncludingDiscontinuedOperationReceivedRoyalties>
<opk:EffectOfLossOnForeignCurrencyDerivativeBeforeTax contextRef="BalanceAsOf_30Sep2012" unitRef="USD" decimals="-3"> -59000 </opk:EffectOfLossOnForeignCurrencyDerivativeBeforeTax>
<opk:EffectOfLossOnForeignCurrencyDerivativeBeforeTax xsi:nil="true" contextRef="BalanceAsOf_30Sep2012_More_Than_One_Hundred_Eighty_Member" unitRef="USD"/>
<opk:EffectOfLossOnForeignCurrencyDerivativeBeforeTax xsi:nil="true" contextRef="BalanceAsOf_30Sep2012_Ninety_One_To_One_Hundred_Twenty_Member" unitRef="USD"/>
<opk:EffectOfLossOnForeignCurrencyDerivativeBeforeTax xsi:nil="true" contextRef="BalanceAsOf_30Sep2012_One_Hundred_Twenty_One_To_One_Hundred_Eighty_Member" unitRef="USD"/>
<opk:EffectOfLossOnForeignCurrencyDerivativeBeforeTax contextRef="BalanceAsOf_30Sep2012_Sixty_One_To_Ninety_Member" unitRef="USD" decimals="-3"> -8000 </opk:EffectOfLossOnForeignCurrencyDerivativeBeforeTax>
<opk:EffectOfLossOnForeignCurrencyDerivativeBeforeTax contextRef="BalanceAsOf_30Sep2012_Thirty_One_To_Sixty_Member" unitRef="USD" decimals="-3"> -15000 </opk:EffectOfLossOnForeignCurrencyDerivativeBeforeTax>
<opk:EffectOfLossOnForeignCurrencyDerivativeBeforeTax contextRef="BalanceAsOf_30Sep2012_Zero_To_Thirty_Member" unitRef="USD" decimals="-3"> -36000 </opk:EffectOfLossOnForeignCurrencyDerivativeBeforeTax>
<opk:EquityInvestment contextRef="BalanceAsOf_31Dec2010" unitRef="USD" decimals="-5"> 700000 </opk:EquityInvestment>
<opk:EquityInvestmentYear contextRef="BalanceAsOf_30Sep2012_Biozone_Member"> 2012 </opk:EquityInvestmentYear>
<opk:EquityInvestmentYear contextRef="BalanceAsOf_30Sep2012_Biozone_Pharmaceuticals_Inc_Member"> 2012 </opk:EquityInvestmentYear>
<opk:EquityInvestmentYear contextRef="BalanceAsOf_30Sep2012_Chroma_Dex_Member"> 2012 </opk:EquityInvestmentYear>
<opk:EquityInvestmentYear contextRef="BalanceAsOf_30Sep2012_Cocrystal_Member"> 2009 </opk:EquityInvestmentYear>
<opk:EquityInvestmentYear contextRef="BalanceAsOf_30Sep2012_Fabrus_Member"> 2010 </opk:EquityInvestmentYear>
<opk:EquityInvestmentYear contextRef="BalanceAsOf_30Sep2012_Neovasc_Member"> 2011 </opk:EquityInvestmentYear>
<opk:EquityInvestmentYear contextRef="BalanceAsOf_30Sep2012_Neovasc_Options_Member"> 2011 </opk:EquityInvestmentYear>
<opk:EquityInvestmentYear contextRef="BalanceAsOf_30Sep2012_Sorrento_Member"> 2009 </opk:EquityInvestmentYear>
<opk:EquityInvestmentYear contextRef="BalanceAsOf_30Sep2012_Tesaro_Member"> 2010 </opk:EquityInvestmentYear>
<opk:ExercisePriceOfWarrantsAcquiredInEquityMethodInvestment contextRef="OneMonthsEnded_29Feb2012_Biozone_Pharmaceuticals_Inc_Member" unitRef="USDEPS" decimals="2"> 0.40 </opk:ExercisePriceOfWarrantsAcquiredInEquityMethodInvestment>
<opk:ExercisePriceOfWarrantsAcquiredInEquityMethodInvestment contextRef="OneMonthsEnded_29Feb2012_Chromadex_Corporation_Member" unitRef="USDEPS" decimals="2"> 0.75 </opk:ExercisePriceOfWarrantsAcquiredInEquityMethodInvestment>
<opk:FairValueOfContingentConsiderationPeriodIncrease contextRef="Jan-01-2012_Sep-30-2012" unitRef="USD" decimals="-3"> 2665000 </opk:FairValueOfContingentConsiderationPeriodIncrease>
<opk:FairValueOfWarrantsAcquiredInEquityMethodInvestment contextRef="OneMonthEnded_31Aug2011_Neovasc_Inc_Member" unitRef="USD" decimals="-5"> 700000 </opk:FairValueOfWarrantsAcquiredInEquityMethodInvestment>
<opk:FinancingForVariableInterestEntities contextRef="BalanceAsOf_30Nov2010_Fabrus_Inc_Member" unitRef="USD" decimals="-5"> 2100000 </opk:FinancingForVariableInterestEntities>
<opk:FinancingForVariableInterestEntities contextRef="BalanceAsOf_30Nov2010_Investments_Member_Fabrus_Member" unitRef="USD" decimals="-5"> 2100000 </opk:FinancingForVariableInterestEntities>
<opk:FiniteLivedResearchAndDevelopmentInProcess contextRef="BalanceAsOf_31Dec2011" unitRef="USD" decimals="-3"> 10000000 </opk:FiniteLivedResearchAndDevelopmentInProcess>
<opk:FiniteLivedResearchAndDevelopmentInProcess contextRef="BalanceAsOf_30Sep2012" unitRef="USD" decimals="-3"> 11504000 </opk:FiniteLivedResearchAndDevelopmentInProcess>
<opk:FirstInstallmentInvestment contextRef="BalanceAsOf_21Sep2009" unitRef="USD" decimals="-5"> 2500000 </opk:FirstInstallmentInvestment>
<opk:ForeignCurrencyMeasurement contextRef="Jan-01-2012_Sep-30-2012" unitRef="USD" decimals="-3"> 204000 </opk:ForeignCurrencyMeasurement>
<opk:FundForResearchAgreement contextRef="BalanceAsOf_29Feb2012" unitRef="USD" decimals="-5"> 900000 </opk:FundForResearchAgreement>
<opk:GainLossFromContinuingOperationsBeforeInvestmentLosses contextRef="NineMonthsEnded_30Sep2011" unitRef="USD" decimals="-3"> -15670000 </opk:GainLossFromContinuingOperationsBeforeInvestmentLosses>
<opk:GainLossFromContinuingOperationsBeforeInvestmentLosses contextRef="ThreeMonthsEnded_30Sep2011" unitRef="USD" decimals="-3"> -6448000 </opk:GainLossFromContinuingOperationsBeforeInvestmentLosses>
<opk:GainLossFromContinuingOperationsBeforeInvestmentLosses contextRef="Jan-01-2012_Sep-30-2012" unitRef="USD" decimals="-3"> -27219000 </opk:GainLossFromContinuingOperationsBeforeInvestmentLosses>
<opk:GainLossFromContinuingOperationsBeforeInvestmentLosses contextRef="ThreeMonthsEnded_30Sep2012" unitRef="USD" decimals="-3"> -9361000 </opk:GainLossFromContinuingOperationsBeforeInvestmentLosses>
<opk:GrossRentIsForTwoYearTerm contextRef="BalanceAsOf_01Nov2009_Trsi_Member" unitRef="USD" decimals="-3"> 40000 </opk:GrossRentIsForTwoYearTerm>
<opk:GrossRentPayableUnderLease contextRef="ThreeMonthsEnded_30Sep2011" unitRef="USD" decimals="-5"> 200000 </opk:GrossRentPayableUnderLease>
<opk:InvestmentInVariableInterestEntities contextRef="OneMonthEnded_30Sep2009_Cocrystal_Discovery_Inc_Member_Investments_Member" unitRef="USD" decimals="-5"> 2500000 </opk:InvestmentInVariableInterestEntities>
<opk:InvestmentInVariableInterestEntities contextRef="OneMonthEnded_31Oct2011_Cocrystal_Discovery_Inc_Member_Investments_Member_Teva_Pharmaceutical_Industries_Ltd_Member" unitRef="USD" decimals="-5"> 7500000 </opk:InvestmentInVariableInterestEntities>
<opk:IssuanceOfCommonStockToAcquireEntity contextRef="Jan-01-2012_Sep-30-2012" unitRef="USD" decimals="-3"> 805000 </opk:IssuanceOfCommonStockToAcquireEntity>
<opk:LeaseRentPerMonthForFifthYear contextRef="OneMonthEnded_30Nov2007_Real_Estate_Holdings_Llc_Member" unitRef="USD" decimals="-3"> 24000 </opk:LeaseRentPerMonthForFifthYear>
<opk:LeaseRentPerMonthForFirstYear contextRef="OneMonthEnded_30Nov2007_Real_Estate_Holdings_Llc_Member" unitRef="USD" decimals="-3"> 18000 </opk:LeaseRentPerMonthForFirstYear>
<opk:LeaseSpaceInOfficeBuildingHavingPrincipalOffice contextRef="OneMonthEnded_30Nov2007_Real_Estate_Holdings_Llc_Member" unitRef="Square_Foot" decimals="INF"> 8300 </opk:LeaseSpaceInOfficeBuildingHavingPrincipalOffice>
<opk:LicensingFeesPaid contextRef="BalanceAsOf_05Mar2010_Management_One_Member" unitRef="USD" decimals="-5"> 100000 </opk:LicensingFeesPaid>
<opk:LicensingFeesPreviouslyPaid contextRef="BalanceAsOf_05Mar2010_Management_One_Member" unitRef="USD" decimals="-3"> 50000 </opk:LicensingFeesPreviouslyPaid>
<opk:LoanToBzne contextRef="BalanceAsOf_18Apr2012" unitRef="USD" decimals="-5"> 300000 </opk:LoanToBzne>
<opk:LoanToBzne contextRef="BalanceAsOf_30Jun2012" unitRef="USD" decimals="-5"> 100000 </opk:LoanToBzne>
<opk:MaturitiesOfShortTermMarketableSecurities contextRef="NineMonthsEnded_30Sep2011" unitRef="USD" decimals="-3"> 59982000 </opk:MaturitiesOfShortTermMarketableSecurities>
<opk:MaturitiesOfShortTermMarketableSecurities contextRef="Jan-01-2012_Sep-30-2012" unitRef="USD" decimals="-3"> 10000000 </opk:MaturitiesOfShortTermMarketableSecurities>
<opk:MaturityDateOfSecurity contextRef="BalanceAsOf_30Sep2012_U_S_Treasury_Securities_Member"> 2012-12-20 </opk:MaturityDateOfSecurity>
<opk:MaximumNumberOfDaysInterestBearingInstrumentsWithOriginalMaturitiesToConsiderAsCashEquivalent contextRef="Jan-01-2012_Sep-30-2012"> P90D </opk:MaximumNumberOfDaysInterestBearingInstrumentsWithOriginalMaturitiesToConsiderAsCashEquivalent>
<opk:MaximumNumberOfDaysInterestBearingInstrumentsWithRemainingMaturitiesToConsiderAsMarketableSecurities contextRef="Jan-01-2012_Sep-30-2012"> P90D </opk:MaximumNumberOfDaysInterestBearingInstrumentsWithRemainingMaturitiesToConsiderAsMarketableSecurities>
<opk:MaximumOwnershipPercentageHeldByMembers contextRef="BalanceAsOf_21Sep2009_Dr_Richard_Lerner_Member" unitRef="Pure" decimals="2"> 0.01 </opk:MaximumOwnershipPercentageHeldByMembers>
<opk:MaximumOwnershipPercentageHeldByMembers contextRef="BalanceAsOf_17Aug2011_Management_Four_Member" unitRef="Pure" decimals="2"> 0.01 </opk:MaximumOwnershipPercentageHeldByMembers>
<opk:MinimumNumberOfDaysInterestBearingInstrumentsWithOriginalMaturitiesToConsiderAsMarketableSecurities contextRef="Jan-01-2012_Sep-30-2012"> P90D </opk:MinimumNumberOfDaysInterestBearingInstrumentsWithOriginalMaturitiesToConsiderAsMarketableSecurities>
<opk:NumberOfAncillaryTransaction contextRef="BalanceAsOf_31Aug2012_Farmadiet_Acquisition_Member" unitRef="Transaction" decimals="INF"> 2 </opk:NumberOfAncillaryTransaction>
<opk:NumberOfCommonSharesToBeIssuedOnConversionOfPreferredStock contextRef="BalanceAsOf_30Sep2012" unitRef="Shares" decimals="INF"> 12110750 </opk:NumberOfCommonSharesToBeIssuedOnConversionOfPreferredStock>
<opk:NumberOfConvertibleSeriesPreferredStockHeldFromAgreement contextRef="BalanceAsOf_21Sep2009" unitRef="Shares" decimals="INF"> 1701723 </opk:NumberOfConvertibleSeriesPreferredStockHeldFromAgreement>
<opk:NumberOfCustomerRepresentation contextRef="Jan-01-2012_Sep-30-2012" unitRef="Customer" decimals="INF"> 0 </opk:NumberOfCustomerRepresentation>
<opk:NumberOfCustomerRepresentation contextRef="ThreeMonthsEnded_30Sep2012" unitRef="Customer" decimals="INF"> 0 </opk:NumberOfCustomerRepresentation>
<opk:NumberOfEqualInstallmentsPayableForAdditionalInvestment contextRef="BalanceAsOf_21Sep2009" unitRef="Installment" decimals="INF"> 2 </opk:NumberOfEqualInstallmentsPayableForAdditionalInvestment>
<opk:NumberOfLicenseAgreements contextRef="BalanceAsOf_05Mar2010" unitRef="License" decimals="INF"> 2 </opk:NumberOfLicenseAgreements>
<opk:NumberOfOperatingSegment contextRef="BalanceAsOf_30Sep2012" unitRef="Segment" decimals="INF"> 2 </opk:NumberOfOperatingSegment>
<opk:NumberOfReportableSegment contextRef="BalanceAsOf_30Sep2012" unitRef="Segment" decimals="INF"> 1 </opk:NumberOfReportableSegment>
<opk:NumberOfSharesIssuedAtClosingDate contextRef="BalanceAsOf_31Aug2012_Farmadiet_Acquisition_Member" unitRef="Shares" decimals="INF"> 125000 </opk:NumberOfSharesIssuedAtClosingDate>
<opk:NumberOfSharesIssuedAtClosingDate contextRef="BalanceAsOf_31Aug2012_Product_In_Development_Member_Farmadiet_Acquisition_Member" unitRef="Shares" decimals="INF"> 70421 </opk:NumberOfSharesIssuedAtClosingDate>
<opk:NumberOfSharesIssuedUponAchievingCertainMilestone contextRef="BalanceAsOf_31Aug2012_Farmadiet_Acquisition_Member" unitRef="Shares" decimals="INF"> 125000 </opk:NumberOfSharesIssuedUponAchievingCertainMilestone>
<opk:NumberOfSharesWarrantsAcquiredInEquityMethodInvestment contextRef="OneMonthEnded_31Aug2011_Neovasc_Inc_Member" unitRef="Shares" decimals="-6"> 1000000 </opk:NumberOfSharesWarrantsAcquiredInEquityMethodInvestment>
<opk:NumberOfTradingDays contextRef="BalanceAsOf_29Dec2011_Finetech_Acquisition_Member"> P10D </opk:NumberOfTradingDays>
<opk:NumberOfTradingDays contextRef="BalanceAsOf_31Aug2012_Product_In_Development_Member_Farmadiet_Acquisition_Member"> P10D </opk:NumberOfTradingDays>
<opk:NumberOfYearsOverWhichRevenueWillBeRecognized contextRef="OneMonthEnded_31Aug2011_Neovasc_Inc_Member"> P3Y </opk:NumberOfYearsOverWhichRevenueWillBeRecognized>
<opk:NumberOfYearsOverWhichRevenueWillBeRecognized contextRef="OneMonthEnded_31Aug2012_Neovasc_Member"> P3Y </opk:NumberOfYearsOverWhichRevenueWillBeRecognized>
<opk:OutstandingCommonSharesAcquired contextRef="BalanceAsOf_10Jun2009_Sorrento_Member" unitRef="Pure" decimals="2"> 0.33 </opk:OutstandingCommonSharesAcquired>
<opk:OwnershipPercentageHeld contextRef="BalanceAsOf_21Sep2011_Biozone_Pharmaceuticals_Inc_Member_Management_Four_Member"> less than 1% </opk:OwnershipPercentageHeld>
<opk:OwnershipPercentageHeld contextRef="BalanceAsOf_29Feb2012_Chromadex_Corporation_Member_Management_Five_Member"> less than 1% </opk:OwnershipPercentageHeld>
<opk:OwnershipPercentageHeldByDirector contextRef="OneMonthEnded_30Nov2010_Fabrus_Inc_Member" unitRef="Pure" decimals="2"> 0.05 </opk:OwnershipPercentageHeldByDirector>
<opk:OwnershipPercentageHeldByMembers contextRef="BalanceAsOf_17Aug2011_Management_One_Member" unitRef="Pure" decimals="2"> 0.36 </opk:OwnershipPercentageHeldByMembers>
<opk:OwnershipPercentageHeldByMembers contextRef="BalanceAsOf_17Aug2011_Management_Two_Member" unitRef="Pure" decimals="2"> 0.06 </opk:OwnershipPercentageHeldByMembers>
<opk:OwnershipPercentageHeldByMembers contextRef="BalanceAsOf_29Feb2012_Chromadex_Corporation_Member" unitRef="Pure" decimals="3"> 0.015 </opk:OwnershipPercentageHeldByMembers>
<opk:OwnershipPercentageHeldByMembers contextRef="BalanceAsOf_29Feb2012_Gamma_Trust_Member" unitRef="Pure" decimals="2"> 0.16 </opk:OwnershipPercentageHeldByMembers>
<opk:OwnershipPercentageHeldByMembers contextRef="BalanceAsOf_29Feb2012_Hsu_Gamma_Member" unitRef="Pure" decimals="2"> 0.01 </opk:OwnershipPercentageHeldByMembers>
<opk:OwnershipPercentageOfVariableInterestEntityByRelatedPartyGroup contextRef="BalanceAsOf_30Sep2012_Hsiao_And_Lerner_Member" unitRef="Pure" decimals="2"> 0.24 </opk:OwnershipPercentageOfVariableInterestEntityByRelatedPartyGroup>
<opk:OwnershipPercentageOfVariableInterestEntityByRelatedPartyGroup contextRef="BalanceAsOf_30Sep2012_Gamma_Trust_Member_Fabrus_And_Drs_Frost_Member" unitRef="Pure" decimals="2"> 0.16 </opk:OwnershipPercentageOfVariableInterestEntityByRelatedPartyGroup>
<opk:OwnershipPercentageOfVariablesInterestEntity contextRef="BalanceAsOf_30Sep2012_Fabrus_And_Drs_Frost_Member" unitRef="Pure" decimals="2"> 0.13 </opk:OwnershipPercentageOfVariablesInterestEntity>
<opk:PercentageInBoardOfManagers contextRef="BalanceAsOf_30Sep2012_Fabrus_And_Drs_Frost_Member_2" unitRef="Pure" decimals="2"> 0.40 </opk:PercentageInBoardOfManagers>
<opk:PercentageOfCustomerInTotalRevenue contextRef="Jan-01-2012_Sep-30-2012" unitRef="Pure" decimals="1"> 0.1 </opk:PercentageOfCustomerInTotalRevenue>
<opk:PercentageOfCustomerInTotalRevenue contextRef="ThreeMonthsEnded_30Sep2012" unitRef="Pure" decimals="1"> 0.1 </opk:PercentageOfCustomerInTotalRevenue>
<opk:PortionOfAmountPayableOnCashOrSharesOnAchievingMilestones contextRef="BalanceAsOf_31Aug2012_Product_In_Development_Member_Farmadiet_Acquisition_Member" unitRef="Pure" decimals="2"> 0.75 </opk:PortionOfAmountPayableOnCashOrSharesOnAchievingMilestones>
<opk:PortionOfBusinessAcquisitionCostOfAcquiredEntityCashPaid contextRef="BalanceAsOf_31Aug2012_Farmadiet_Acquisition_Member" unitRef="Pure" decimals="2"> 0.5 </opk:PortionOfBusinessAcquisitionCostOfAcquiredEntityCashPaid>
<opk:PortionOfBusinessAcquisitionCostOfAcquiredEntityCashPaid contextRef="BalanceAsOf_31Aug2012_Product_In_Development_Member_Farmadiet_Acquisition_Member" unitRef="Pure" decimals="2"> 0.25 </opk:PortionOfBusinessAcquisitionCostOfAcquiredEntityCashPaid>
<opk:PortionOfDeferredPaymentPaidAtOurOptionInCashOrShares contextRef="BalanceAsOf_31Aug2012_Farmadiet_Acquisition_Member" unitRef="Pure" decimals="2"> 0.5 </opk:PortionOfDeferredPaymentPaidAtOurOptionInCashOrShares>
<opk:PortionOfPaidInEighteenMonthsAfterClosingDate contextRef="BalanceAsOf_31Aug2012_Farmadiet_Acquisition_Member" unitRef="Pure" decimals="2"> 0.25 </opk:PortionOfPaidInEighteenMonthsAfterClosingDate>
<opk:PortionOfPaidOnFirstAnniversaryOfClosingDate contextRef="BalanceAsOf_31Aug2012_Farmadiet_Acquisition_Member" unitRef="Pure" decimals="2"> 0.25 </opk:PortionOfPaidOnFirstAnniversaryOfClosingDate>
<opk:PreviousInvestmentByGroupOfInvestor contextRef="BalanceAsOf_21Sep2009" unitRef="USD" decimals="-5"> 5000000 </opk:PreviousInvestmentByGroupOfInvestor>
<opk:PromissoryNotesMaturityDate contextRef="OneMonthsEnded_29Feb2012_Biozone_Pharmaceuticals_Inc_Member"> 2014-02-24 </opk:PromissoryNotesMaturityDate>
<opk:ProvisionForReversalOfInventoryReserves contextRef="NineMonthsEnded_30Sep2011" unitRef="USD" decimals="-3"> 534000 </opk:ProvisionForReversalOfInventoryReserves>
<opk:ProvisionForReversalOfInventoryReserves contextRef="Jan-01-2012_Sep-30-2012" unitRef="USD" decimals="-3"> 1520000 </opk:ProvisionForReversalOfInventoryReserves>
<opk:ProvisionRecoveryOfForDoubtfulAccounts contextRef="NineMonthsEnded_30Sep2011" unitRef="USD" decimals="-3"> 260000 </opk:ProvisionRecoveryOfForDoubtfulAccounts>
<opk:ProvisionRecoveryOfForDoubtfulAccounts contextRef="Jan-01-2012_Sep-30-2012" unitRef="USD" decimals="-3"> 11000 </opk:ProvisionRecoveryOfForDoubtfulAccounts>
<opk:ReimbursementOfCertainExpenses contextRef="BalanceAsOf_05Mar2010_Management_One_Member" unitRef="USD" decimals="-3"> 50000 </opk:ReimbursementOfCertainExpenses>
<opk:ReimbursementPaidToRelatedPartyForTravel contextRef="NineMonthsEnded_30Sep2011" unitRef="USD" decimals="-3"> 127000 </opk:ReimbursementPaidToRelatedPartyForTravel>
<opk:ReimbursementPaidToRelatedPartyForTravel contextRef="ThreeMonthsEnded_30Sep2011" unitRef="USD" decimals="-3"> 14000 </opk:ReimbursementPaidToRelatedPartyForTravel>
<opk:ReimbursementPaidToRelatedPartyForTravel contextRef="Jan-01-2012_Sep-30-2012" unitRef="USD" decimals="-3"> 181000 </opk:ReimbursementPaidToRelatedPartyForTravel>
<opk:ReimbursementPaidToRelatedPartyForTravel contextRef="ThreeMonthsEnded_30Sep2012" unitRef="USD" decimals="-3"> 52000 </opk:ReimbursementPaidToRelatedPartyForTravel>
<opk:ResearchAgreementMaturityPeriod contextRef="Jan-01-2012_Sep-30-2012"> P5Y </opk:ResearchAgreementMaturityPeriod>
<opk:ResearchAndDevelopmentAgreementAmountForPeriod contextRef="OneMonthEnded_30Jun2010" unitRef="USD" decimals="-5"> 200000 </opk:ResearchAndDevelopmentAgreementAmountForPeriod>
<opk:RevenueFromReceiptOfEquity contextRef="Jan-01-2012_Sep-30-2012" unitRef="USD" decimals="-3"> 159000 </opk:RevenueFromReceiptOfEquity>
<opk:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrantDateFairValue contextRef="OneMonthEnded_31Aug2011_Neovasc_Inc_Member" unitRef="USD" decimals="-5"> 800000 </opk:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrantDateFairValue>
<opk:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrantDateFairValue contextRef="OneMonthEnded_31Aug2012_Neovasc_Member" unitRef="USD" decimals="-5"> 100000 </opk:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrantDateFairValue>
<opk:TermOfUseOfSpaceToHouseMolecularDiagnosticsOperations contextRef="BalanceAsOf_20Jul2010_Trsi_Member"> P2Y </opk:TermOfUseOfSpaceToHouseMolecularDiagnosticsOperations>
<opk:TimeOfTransactionPercentageOwned contextRef="BalanceAsOf_28Jan2011" unitRef="Pure" decimals="2"> 0.04 </opk:TimeOfTransactionPercentageOwned>
<opk:TransferOutToEquityMethodInvestment contextRef="NineMonthsEnded_30Sep2012_Bnze_Note_And_Bnze_Warrants_Member" unitRef="USD" decimals="-3"> -1276000 </opk:TransferOutToEquityMethodInvestment>
<opk:TransferOutToEquityMethodInvestment xsi:nil="true" contextRef="NineMonthsEnded_30Sep2012_Contingent_Consideration_Member" unitRef="USD"/>
<opk:TransferOutToEquityMethodInvestment xsi:nil="true" contextRef="NineMonthsEnded_30Sep2012_Deferred_Acquisition_Payments_Net_Of_Discount_Member" unitRef="USD"/>
<opk:UnrealizedGainOnInvestmentsOptionsAndWarrants contextRef="BalanceAsOf_30Sep2012" unitRef="USD" decimals="-3"> 6018000 </opk:UnrealizedGainOnInvestmentsOptionsAndWarrants>
<opk:UnrealizedGainOnWarrants contextRef="NineMonthsEnded_30Sep2012_Neovasc_Member" unitRef="USD" decimals="-5"> 200000 </opk:UnrealizedGainOnWarrants>
<opk:ValueOfStockConsiderationHeldInEscrowAccount contextRef="OneMonthEnded_31Oct2011_Claros_Diagnostics_Member" unitRef="USD" decimals="-5"> 5000000 </opk:ValueOfStockConsiderationHeldInEscrowAccount>
<opk:VariableInterestEntityEntityAccountingMethod contextRef="BalanceAsOf_30Sep2012_Biozone_Member"> VIE,equity method </opk:VariableInterestEntityEntityAccountingMethod>
<opk:VariableInterestEntityEntityAccountingMethod contextRef="BalanceAsOf_30Sep2012_Biozone_Pharmaceuticals_Inc_Member"> VIE, investment, available for sale </opk:VariableInterestEntityEntityAccountingMethod>
<opk:VariableInterestEntityEntityAccountingMethod contextRef="BalanceAsOf_30Sep2012_Chroma_Dex_Member"> Investment, available for sale </opk:VariableInterestEntityEntityAccountingMethod>
<opk:VariableInterestEntityEntityAccountingMethod contextRef="BalanceAsOf_30Sep2012_Cocrystal_Member"> Equity method </opk:VariableInterestEntityEntityAccountingMethod>
<opk:VariableInterestEntityEntityAccountingMethod contextRef="BalanceAsOf_30Sep2012_Fabrus_Member"> VIE, equity method </opk:VariableInterestEntityEntityAccountingMethod>
<opk:VariableInterestEntityEntityAccountingMethod contextRef="BalanceAsOf_30Sep2012_Neovasc_Member"> Equity method, cost (warrants) </opk:VariableInterestEntityEntityAccountingMethod>
<opk:VariableInterestEntityEntityAccountingMethod contextRef="BalanceAsOf_30Sep2012_Neovasc_Options_Member"> Investment, available for sale </opk:VariableInterestEntityEntityAccountingMethod>
<opk:VariableInterestEntityEntityAccountingMethod contextRef="BalanceAsOf_30Sep2012_Sorrento_Member"> Equity method </opk:VariableInterestEntityEntityAccountingMethod>
<opk:VariableInterestEntityEntityAccountingMethod contextRef="BalanceAsOf_30Sep2012_Tesaro_Member"> Investment, available for sale </opk:VariableInterestEntityEntityAccountingMethod>
<opk:VariableInterestEntityEntityAccumulatedLossesInInvestees contextRef="BalanceAsOf_30Sep2012" unitRef="USD" decimals="-3"> 4115000 </opk:VariableInterestEntityEntityAccumulatedLossesInInvestees>
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<us-gaap:VariableInterestEntityEntityMaximumLossExposureAmount contextRef="BalanceAsOf_30Sep2012_Sorrento_Member" unitRef="USD" decimals="-3"> 2300000 </us-gaap:VariableInterestEntityEntityMaximumLossExposureAmount>
<us-gaap:VariableInterestEntityOwnershipPercentage contextRef="OneMonthEnded_30Nov2010_Fabrus_Inc_Member" unitRef="Pure" decimals="2"> 0.13 </us-gaap:VariableInterestEntityOwnershipPercentage>
</xbrl>

1 Subsequent Filing that References this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 2/18/21  Opko Health, Inc.                 10-K       12/31/20  111:16M
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