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| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_OperatingExpenses" xlink:to="loc_OtherCostAndExpenseOperating" order="37" use="optional" weight="1"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_OperatingIncomeLoss" xlink:to="loc_OperatingExpenses" order="38" use="optional" weight="-1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:label="loc_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments"/> |
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| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="loc_OtherNonoperatingIncomeExpense"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:to="loc_OtherNonoperatingIncomeExpense" order="40" use="optional" weight="1"/> |
| | <loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_GainLossFromContinuingOperationsBeforeInvestmentLosses" xlink:label="opk_GainLossFromContinuingOperationsBeforeInvestmentLosses"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="opk_GainLossFromContinuingOperationsBeforeInvestmentLosses" xlink:to="loc_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" order="41" use="optional" weight="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_IncomeTaxExpenseBenefit"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="opk_GainLossFromContinuingOperationsBeforeInvestmentLosses" xlink:to="loc_IncomeTaxExpenseBenefit" order="42" use="optional" weight="-1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeLossFromContinuingOperations" xlink:label="loc_IncomeLossFromContinuingOperations"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_IncomeLossFromContinuingOperations" xlink:to="opk_GainLossFromContinuingOperationsBeforeInvestmentLosses" order="43" use="optional" weight="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_GainLossOnInvestments" xlink:label="loc_GainLossOnInvestments"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_IncomeLossFromContinuingOperations" xlink:to="loc_GainLossOnInvestments" order="44" use="optional" weight="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_NetIncomeLoss"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetIncomeLoss" xlink:to="loc_IncomeLossFromContinuingOperations" order="45" use="optional" weight="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax" xlink:label="loc_IncomeLossFromDiscontinuedOperationsNetOfTax"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetIncomeLoss" xlink:to="loc_IncomeLossFromDiscontinuedOperationsNetOfTax" order="46" use="optional" weight="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic" xlink:label="loc_NetIncomeLossAvailableToCommonStockholdersBasic"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetIncomeLossAvailableToCommonStockholdersBasic" xlink:to="loc_NetIncomeLoss" order="47" use="optional" weight="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PreferredStockDividendsIncomeStatementImpact" xlink:label="loc_PreferredStockDividendsIncomeStatementImpact"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetIncomeLossAvailableToCommonStockholdersBasic" xlink:to="loc_PreferredStockDividendsIncomeStatementImpact" order="48" use="optional" weight="-1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RestructuringCharges" xlink:label="loc_RestructuringCharges"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_OperatingExpenses" xlink:to="loc_RestructuringCharges" order="36.5" use="optional" weight="1" priority="1"/> |
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| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:label="loc_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="loc_DepreciationDepletionAndAmortization"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_DepreciationDepletionAndAmortization" order="50" use="optional" weight="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AccretionExpense" xlink:label="loc_AccretionExpense"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_AccretionExpense" order="51" use="optional" weight="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_ShareBasedCompensation"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_ShareBasedCompensation" order="52" use="optional" weight="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_GainLossOnInvestments" xlink:label="loc_GainLossOnInvestments"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_GainLossOnInvestments" order="53" use="optional" weight="-1"/> |
| | <loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_ProvisionRecoveryOfForDoubtfulAccounts" xlink:label="opk_ProvisionRecoveryOfForDoubtfulAccounts"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="opk_ProvisionRecoveryOfForDoubtfulAccounts" order="54" use="optional" weight="1"/> |
| | <loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_ProvisionForReversalOfInventoryReserves" xlink:label="opk_ProvisionForReversalOfInventoryReserves"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="opk_ProvisionForReversalOfInventoryReserves" order="55" use="optional" weight="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:label="loc_IncreaseDecreaseInAccountsReceivable"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_IncreaseDecreaseInAccountsReceivable" order="56" use="optional" weight="-1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncreaseDecreaseInInventories" xlink:label="loc_IncreaseDecreaseInInventories"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_IncreaseDecreaseInInventories" order="57" use="optional" weight="-1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:label="loc_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" order="58" use="optional" weight="-1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:label="loc_IncreaseDecreaseInOtherOperatingAssets"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_IncreaseDecreaseInOtherOperatingAssets" order="59" use="optional" weight="-1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable" xlink:label="loc_IncreaseDecreaseInAccountsPayable"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_IncreaseDecreaseInAccountsPayable" order="60" use="optional" weight="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities" xlink:label="loc_IncreaseDecreaseInAccruedLiabilities"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_IncreaseDecreaseInAccruedLiabilities" order="61" use="optional" weight="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_NetCashProvidedByUsedInOperatingActivities"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInOperatingActivities" xlink:to="loc_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" order="62" use="optional" weight="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CashProvidedByUsedInOperatingActivitiesDiscontinuedOperations" xlink:label="loc_CashProvidedByUsedInOperatingActivitiesDiscontinuedOperations"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInOperatingActivities" xlink:to="loc_CashProvidedByUsedInOperatingActivitiesDiscontinuedOperations" order="63" use="optional" weight="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:label="loc_CashAndCashEquivalentsPeriodIncreaseDecrease"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:to="loc_NetCashProvidedByUsedInOperatingActivities" order="64" use="optional" weight="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_NetCashProvidedByUsedInInvestingActivities"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:to="loc_NetCashProvidedByUsedInInvestingActivities" order="72" use="optional" weight="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_NetCashProvidedByUsedInFinancingActivities"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock" xlink:label="loc_ProceedsFromIssuanceOfCommonStock"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInFinancingActivities" xlink:to="loc_ProceedsFromIssuanceOfCommonStock" order="73" use="optional" weight="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:label="loc_PaymentsForRepurchaseOfCommonStock"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInFinancingActivities" xlink:to="loc_PaymentsForRepurchaseOfCommonStock" order="74" use="optional" weight="-1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock" xlink:label="loc_PaymentsForRepurchaseOfRedeemablePreferredStock"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInFinancingActivities" xlink:to="loc_PaymentsForRepurchaseOfRedeemablePreferredStock" order="75" use="optional" weight="-1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ProceedsFromLongTermLinesOfCredit" xlink:label="loc_ProceedsFromLongTermLinesOfCredit"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInFinancingActivities" xlink:to="loc_ProceedsFromLongTermLinesOfCredit" order="77" use="optional" weight="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RepaymentsOfLongTermLinesOfCredit" xlink:label="loc_RepaymentsOfLongTermLinesOfCredit"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInFinancingActivities" xlink:to="loc_RepaymentsOfLongTermLinesOfCredit" order="78" use="optional" weight="-1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ProceedsFromIssuanceOrSaleOfEquity" xlink:label="loc_ProceedsFromIssuanceOrSaleOfEquity"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInFinancingActivities" xlink:to="loc_ProceedsFromIssuanceOrSaleOfEquity" order="79" use="optional" weight="1"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:to="loc_NetCashProvidedByUsedInFinancingActivities" order="80" use="optional" weight="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents" xlink:label="loc_EffectOfExchangeRateOnCashAndCashEquivalents"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:to="loc_EffectOfExchangeRateOnCashAndCashEquivalents" order="81" use="optional" weight="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PaymentsToAcquireProductiveAssets" xlink:label="loc_PaymentsToAcquireProductiveAssets"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInInvestingActivities" xlink:to="loc_PaymentsToAcquireProductiveAssets" order="20" use="optional" weight="-1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PaymentsToAcquireEquityMethodInvestments" xlink:label="loc_PaymentsToAcquireEquityMethodInvestments"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInInvestingActivities" xlink:to="loc_PaymentsToAcquireEquityMethodInvestments" order="10" use="optional" weight="-1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_MaturitiesOfShortTermMarketableSecurities" xlink:label="opk_MaturitiesOfShortTermMarketableSecurities"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInInvestingActivities" xlink:to="opk_MaturitiesOfShortTermMarketableSecurities" order="5" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PaymentsToAcquireMarketableSecurities" xlink:label="loc_PaymentsToAcquireMarketableSecurities"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInInvestingActivities" xlink:to="loc_PaymentsToAcquireMarketableSecurities" order="2.5" use="optional" weight="-1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired" xlink:label="loc_PaymentsToAcquireBusinessesNetOfCashAcquired"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInInvestingActivities" xlink:to="loc_PaymentsToAcquireBusinessesNetOfCashAcquired" order="1.25" use="optional" weight="-1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_ForeignCurrencyMeasurement" xlink:label="opk_ForeignCurrencyMeasurement"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="opk_ForeignCurrencyMeasurement" order="60.5" use="optional" weight="-1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_RevenueFromReceiptOfEquity" xlink:label="opk_RevenueFromReceiptOfEquity"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="opk_RevenueFromReceiptOfEquity" order="55.125" use="optional" weight="-1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax" xlink:label="loc_IncomeLossFromDiscontinuedOperationsNetOfTax"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_IncomeLossFromDiscontinuedOperationsNetOfTax" order="25" use="optional" weight="-1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_NetIncomeLoss"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_NetIncomeLoss" order="12.5" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AvailableforsaleSecuritiesTransfersToTradingGainsLossesExcludingOtherThanTemporaryImpairments" xlink:label="loc_AvailableforsaleSecuritiesTransfersToTradingGainsLossesExcludingOtherThanTemporaryImpairments"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="loc_AvailableforsaleSecuritiesTransfersToTradingGainsLossesExcludingOtherThanTemporaryImpairments" order="55.375" use="optional" weight="-1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_FairValueOfContingentConsiderationPeriodIncrease" xlink:label="opk_FairValueOfContingentConsiderationPeriodIncrease"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations" xlink:to="opk_FairValueOfContingentConsiderationPeriodIncrease" order="55.6875" use="optional" weight="1" priority="1"/> |
| | </calculationLink> |
| <roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#BusinessAndOrganization" roleURI="http://opko.com/role/BusinessAndOrganization"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/BusinessAndOrganization" xlink:title="0201 - Disclosure - Business and Organization"/> |
| <roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#SummaryOfSignificantAccountingPolicies" roleURI="http://opko.com/role/SummaryOfSignificantAccountingPolicies"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/SummaryOfSignificantAccountingPolicies" xlink:title="0202 - Disclosure - Summary of Significant Accounting Policies"/> |
| <roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#LossPerShare" roleURI="http://opko.com/role/LossPerShare"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/LossPerShare" xlink:title="0203 - Disclosure - Loss Per Share"/> |
| <roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#CompositionOfCertainFinancialStatementCaptions" roleURI="http://opko.com/role/CompositionOfCertainFinancialStatementCaptions"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/CompositionOfCertainFinancialStatementCaptions" xlink:title="0204 - Disclosure - Composition of Certain Financial Statement Captions"/> |
| <roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#DiscontinuedOperations" roleURI="http://opko.com/role/DiscontinuedOperations"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/DiscontinuedOperations" xlink:title="0206 - Disclosure - Discontinued Operations"/> |
| <roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#FairValueMeasurements" roleURI="http://opko.com/role/FairValueMeasurements"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurements" xlink:title="0207 - Disclosure - Fair Value Measurements"/> |
| <roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#DerivativeContracts" roleURI="http://opko.com/role/DerivativeContracts"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/DerivativeContracts" xlink:title="0208 - Disclosure - Derivative Contracts"/> |
| <roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#RelatedPartyTransactions" roleURI="http://opko.com/role/RelatedPartyTransactions"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/RelatedPartyTransactions" xlink:title="0209 - Disclosure - Related Party Transactions"/> |
| <roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#CommitmentsAndContingencies" roleURI="http://opko.com/role/CommitmentsAndContingencies"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/CommitmentsAndContingencies" xlink:title="0210 - Disclosure - Commitments and Contingencies"/> |
| <roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#Segments" roleURI="http://opko.com/role/Segments"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/Segments" xlink:title="0211 - Disclosure - Segments"/> |
| <roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#SubsequentEvents" roleURI="http://opko.com/role/SubsequentEvents"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/SubsequentEvents" xlink:title="0212 - Disclosure - Subsequent Events"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/SummaryOfSignificantAccountingPoliciesPolicies" xlink:title="0402 - Disclosure - Summary of Significant Accounting Policies (Policies)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/LossPerShareDetailsTextual" xlink:title="0603 - Disclosure - Loss Per Share (Details)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/DiscontinuedOperationsTables" xlink:title="0506 - Disclosure - Discontinued Operations (Tables)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsTables" xlink:title="0507 - Disclosure - Fair Value Measurements (Tables)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/DerivativeContractsTables" xlink:title="0508 - Disclosure - Derivative Contracts (Tables)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/SegmentsTables" xlink:title="0511 - Disclosure - Segments (Tables)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetails" xlink:title="0605 - Disclosure - Acquisitions, Investments, and Licenses (Details)"> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:label="loc_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionContingentConsiderationAtFairValue" xlink:label="loc_BusinessAcquisitionContingentConsiderationAtFairValue"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:to="loc_BusinessAcquisitionContingentConsiderationAtFairValue" order="20" use="optional" weight="-1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayableAndAccruedExpenses" xlink:label="opk_BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayableAndAccruedExpenses"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:to="opk_BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayableAndAccruedExpenses" order="40" use="optional" weight="-1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationGoodwillAmount" xlink:label="loc_BusinessAcquisitionPurchasePriceAllocationGoodwillAmount"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:to="loc_BusinessAcquisitionPurchasePriceAllocationGoodwillAmount" order="60" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill" xlink:label="loc_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:to="loc_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill" order="80" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationPropertyPlantAndEquipment" xlink:label="loc_BusinessAcquisitionPurchasePriceAllocationPropertyPlantAndEquipment"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:to="loc_BusinessAcquisitionPurchasePriceAllocationPropertyPlantAndEquipment" order="100" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssets" xlink:label="loc_BusinessAcquisitionPurchasePriceAllocationCurrentAssets"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:to="loc_BusinessAcquisitionPurchasePriceAllocationCurrentAssets" order="120" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BusinessAcquisitionPurchasePriceAllocationCustomerRelationships" xlink:label="opk_BusinessAcquisitionPurchasePriceAllocationCustomerRelationships"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill" xlink:to="opk_BusinessAcquisitionPurchasePriceAllocationCustomerRelationships" order="20" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BusinessAcquisitionPurchasePriceAllocationTradeName" xlink:label="opk_BusinessAcquisitionPurchasePriceAllocationTradeName"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill" xlink:to="opk_BusinessAcquisitionPurchasePriceAllocationTradeName" order="80" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationOtherAssets" xlink:label="loc_BusinessAcquisitionPurchasePriceAllocationOtherAssets"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:to="loc_BusinessAcquisitionPurchasePriceAllocationOtherAssets" order="110" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationDeferredIncomeTaxesAssetLiabilityNet" xlink:label="us-gaap_BusinessAcquisitionPurchasePriceAllocationDeferredIncomeTaxesAssetLiabilityNet_3"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:to="us-gaap_BusinessAcquisitionPurchasePriceAllocationDeferredIncomeTaxesAssetLiabilityNet_3" order="10" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationNotesPayableAndLongTermDebt" xlink:label="us-gaap_BusinessAcquisitionPurchasePriceAllocationNotesPayableAndLongTermDebt"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:to="us-gaap_BusinessAcquisitionPurchasePriceAllocationNotesPayableAndLongTermDebt" order="15" use="optional" weight="-1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BusinessAcquisitionPurchasePriceAllocationDeferredPayment" xlink:label="opk_BusinessAcquisitionPurchasePriceAllocationDeferredPayment"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:to="opk_BusinessAcquisitionPurchasePriceAllocationDeferredPayment" order="12.5" use="optional" weight="-1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BusinessAcquisitionPurchasePriceAllocationCovenantsNotToCompete" xlink:label="opk_BusinessAcquisitionPurchasePriceAllocationCovenantsNotToCompete"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill" xlink:to="opk_BusinessAcquisitionPurchasePriceAllocationCovenantsNotToCompete" order="30" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BusinessAcquisitionPurchasePriceAllocationProductRegistrations" xlink:label="opk_BusinessAcquisitionPurchasePriceAllocationProductRegistrations"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill" xlink:to="opk_BusinessAcquisitionPurchasePriceAllocationProductRegistrations" order="25" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BusinessAcquisitionPurchasePriceInProcessResearchAndDevelopmentExpensed" xlink:label="opk_BusinessAcquisitionPurchasePriceInProcessResearchAndDevelopmentExpensed"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill" xlink:to="opk_BusinessAcquisitionPurchasePriceInProcessResearchAndDevelopmentExpensed" order="21.5625" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BusinessAcquisitionPurchasePriceAllocationTechnology" xlink:label="opk_BusinessAcquisitionPurchasePriceAllocationTechnology"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill" xlink:to="opk_BusinessAcquisitionPurchasePriceAllocationTechnology" order="20.625" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationEquipment" xlink:label="loc_BusinessAcquisitionPurchasePriceAllocationEquipment"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:to="loc_BusinessAcquisitionPurchasePriceAllocationEquipment" order="70" use="optional" weight="1" priority="1"/> |
| | </calculationLink> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetails1" xlink:title="06052 - Disclosure - Acquisitions, Investments, and Licenses (Details 2)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetailsTextual" xlink:title="06053 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/DiscontinuedOperationsDetails" xlink:title="0606 - Disclosure - Discontinued Operations (Details)"> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperation" xlink:label="loc_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperation"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationAccountsPayable" xlink:label="loc_DisposalGroupIncludingDiscontinuedOperationAccountsPayable"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperation" xlink:to="loc_DisposalGroupIncludingDiscontinuedOperationAccountsPayable" order="40" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperation" xlink:label="loc_AssetsOfDisposalGroupIncludingDiscontinuedOperation"/> |
| | <loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_DisposalGroupIncludingDiscontinuedOperationAccruedExpensesAndOtherLiabilities" xlink:label="opk_DisposalGroupIncludingDiscontinuedOperationAccruedExpensesAndOtherLiabilities"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperation" xlink:to="opk_DisposalGroupIncludingDiscontinuedOperationAccruedExpensesAndOtherLiabilities" order="60" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherCurrentAssets" xlink:label="loc_DisposalGroupIncludingDiscontinuedOperationOtherCurrentAssets"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_AssetsOfDisposalGroupIncludingDiscontinuedOperation" xlink:to="loc_DisposalGroupIncludingDiscontinuedOperationOtherCurrentAssets" order="10" use="optional" weight="1" priority="1"/> |
| | </calculationLink> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/DiscontinuedOperationsDetails1" xlink:title="06061 - Disclosure - Discontinued Operations (Details 1)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/DiscontinuedOperationsDetailsTextual" xlink:title="06062 - Disclosure - Discontinued Operations (Details Textual)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails" xlink:title="06071 - Disclosure - Fair Value Measurements (Details 1)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetailsTextual" xlink:title="06073 - Disclosure - Fair Value Measurements (Details Textual)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/DerivativeContractsDetails" xlink:title="0608 - Disclosure - Derivative Contracts (Details)"> </calculationLink> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/CommitmentsAndContingenciesDetailsTextual" xlink:title="0610 - Disclosure - Commitments and Contingencies (Details)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/SegmentsDetails" xlink:title="0611 - Disclosure - Segments (Details)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/SegmentsDetailsTextual" xlink:title="06111 - Disclosure - Segments (Details Textual)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/BalanceSheetsParenthetical" xlink:title="0111 - Statement - Condensed Consolidated Balance Sheets (Parenthetical) (unaudited)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/SummaryOfSignificantAccountingPoliciesDetails" xlink:title="0602 - Disclosure - Summary of Significant Accounting Policies (Details)"/> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/StatementsOfComprehensiveLoss" xlink:title="0130 - Statement - Condensed Consolidated Statements of Comprehensive Loss (unaudited)"> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax" xlink:label="us-gaap_ComprehensiveIncomeNetOfTax"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="loc_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_ComprehensiveIncomeNetOfTax" xlink:to="loc_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" order="20" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax" xlink:label="loc_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_ComprehensiveIncomeNetOfTax" xlink:to="loc_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax" order="10" use="optional" weight="1" priority="1"/> |
| | <loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic" xlink:label="loc_NetIncomeLossAvailableToCommonStockholdersBasic"/> |
| | <calculationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="us-gaap_ComprehensiveIncomeNetOfTax" xlink:to="loc_NetIncomeLossAvailableToCommonStockholdersBasic" order="5" use="optional" weight="1" priority="1"/> |
| | </calculationLink> |
| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionsInvestmentsAndLicenses" xlink:title="0205 - Disclosure - Acquisitions, Investments, and Licenses"/> |
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| <calculationLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionsInvestmentsAndLicensesDetails1" xlink:title="06051 - Disclosure - Acquisitions, Investments, and Licenses (Details 1)"> |
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