SEC Info℠  
    Home      Search      My Interests      Help      Sign In      Please Sign In

Opko Health, Inc. – ‘10-Q’ for 9/30/12 – ‘EX-101.DEF’

On:  Friday, 11/9/12, at 4:31pm ET   ·   For:  9/30/12   ·   Accession #:  1193125-12-463415   ·   File #:  1-33528

Previous ‘10-Q’:  ‘10-Q’ on 8/9/12 for 6/30/12   ·   Next:  ‘10-Q’ on 5/10/13 for 3/31/13   ·   Latest:  ‘10-Q’ on 11/6/23 for 9/30/23   ·   1 Reference:  By:  Opko Health, Inc. – ‘10-K’ on 2/18/21 for 12/31/20

Find Words in Filings emoji
 		  in    Show  and   ↓Hints

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

11/09/12  Opko Health, Inc.                 10-Q        9/30/12   60:6.7M                                   Donnelley … Solutions/FA

Quarterly Report   —   Form 10-Q   —   Sect. 13 / 15(d) – SEA’34
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-Q        Quarterly Report                                    HTML    456K 
 2: EX-2.8      Plan of Acquisition, Reorganization, Arrangement,   HTML    287K 
                Liquidation or Succession                                        
 3: EX-31.1     Certification -- §302 - SOA'02                      HTML     25K 
 4: EX-31.2     Certification -- §302 - SOA'02                      HTML     25K 
 5: EX-32.1     Certification -- §906 - SOA'02                      HTML     19K 
 6: EX-32.2     Certification -- §906 - SOA'02                      HTML     18K 
40: R1          Document and Entity Information                     HTML     38K 
30: R2          Condensed Consolidated Balance Sheets               HTML    134K 
38: R3          Condensed Consolidated Balance Sheets               HTML     60K 
                (Parenthetical) (Unaudited)                                      
42: R4          Condensed Consolidated Statements of Operations     HTML    116K 
                (Unaudited)                                                      
55: R5          Condensed Consolidated Statements of Comprehensive  HTML     39K 
                Loss (Unaudited)                                                 
32: R6          Condensed Consolidated Statements of Cash Flows     HTML    168K 
                (Unaudited)                                                      
37: R7          Business and Organization                           HTML     29K 
27: R8          Summary of Significant Accounting Policies          HTML     41K 
18: R9          Loss Per Share                                      HTML     24K 
56: R10         Composition of Certain Financial Statement          HTML     55K 
                Captions                                                         
44: R11         Acquisitions, Investments, and Licenses             HTML     98K 
43: R12         Discontinued Operations                             HTML     44K 
48: R13         Fair Value Measurements                             HTML     86K 
49: R14         Derivative Contracts                                HTML     43K 
47: R15         Related Party Transactions                          HTML     40K 
50: R16         Commitments and Contingencies                       HTML     26K 
39: R17         Segments                                            HTML     61K 
41: R18         Subsequent Events                                   HTML     23K 
46: R19         Summary of Significant Accounting Policies          HTML    100K 
                (Policies)                                                       
60: R20         Composition of Certain Financial Statement          HTML     54K 
                Captions (Tables)                                                
52: R21         Acquisitions, Investments, and Licenses (Tables)    HTML     75K 
34: R22         Discontinued Operations (Tables)                    HTML     39K 
45: R23         Fair Value Measurements (Tables)                    HTML     85K 
36: R24         Derivative Contracts (Tables)                       HTML     32K 
15: R25         Segments (Tables)                                   HTML     52K 
53: R26         Summary of Significant Accounting Policies          HTML     40K 
                (Details)                                                        
57: R27         Loss Per Share (Details)                            HTML     28K 
23: R28         Composition of Certain Financial Statement          HTML    115K 
                Captions (Details)                                               
22: R29         Acquisitions, Investments, and Licenses (Details)   HTML     70K 
25: R30         Acquisitions, Investments, and Licenses (Details    HTML     49K 
                1)                                                               
26: R31         Acquisitions, Investments, and Licenses (Details    HTML     64K 
                2)                                                               
28: R32         Acquisitions, Investments, and Licenses (Details    HTML    286K 
                Textual)                                                         
14: R33         Discontinued Operations (Details)                   HTML     34K 
51: R34         Discontinued Operations (Details 1)                 HTML     34K 
33: R35         Discontinued Operations (Details Textual)           HTML     23K 
35: R36         Fair Value Measurements (Details)                   HTML     41K 
17: R37         Fair Value Measurements (Details 1)                 HTML     73K 
59: R38         Fair Value Measurements (Details 2)                 HTML     41K 
13: R39         Fair Value Measurements (Details Textual)           HTML     38K 
29: R40         Derivative Contracts (Details)                      HTML     33K 
54: R41         Related Party Transactions (Details)                HTML    239K 
16: R42         Commitments and Contingencies (Details)             HTML     33K 
21: R43         Segments (Details)                                  HTML     42K 
24: R44         Segments (Details Textual)                          HTML     30K 
31: R45         Subsequent Events (Details)                         HTML     34K 
58: XML         IDEA XML File -- Filing Summary                      XML     88K 
20: EXCEL       IDEA Workbook of Financial Reports (.xls)            XLS   1.03M 
 7: EX-101.INS  XBRL Instance -- opk-20120930                        XML   1.31M 
 9: EX-101.CAL  XBRL Calculations -- opk-20120930_cal                XML    186K 
10: EX-101.DEF  XBRL Definitions -- opk-20120930_def                 XML    592K 
11: EX-101.LAB  XBRL Labels -- opk-20120930_lab                      XML   1.25M 
12: EX-101.PRE  XBRL Presentations -- opk-20120930_pre               XML    848K 
 8: EX-101.SCH  XBRL Schema -- opk-20120930                          XSD    187K 
19: ZIP         XBRL Zipped Folder -- 0001193125-12-463415-xbrl      Zip    146K

‘EX-101.DEF’   —   XBRL Definitions — opk-20120930_def

This Exhibit is an XBRL XML File.

                                                                                                                                                                                
<?xml version="1.0" encoding="windows-1252"?>
<!-- XBRL document created by RR Donnelley Tagger version 10.0.0.199; Copyright (C) RR Donnelley -->
<!-- Based on XBRL 2.1 -->
<link:linkbase xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://www.xbrl.org/2003/linkbase" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
<link:roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#BalanceSheets" roleURI="http://opko.com/role/BalanceSheets"/>
<link:roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#BalanceSheetsParenthetical" roleURI="http://opko.com/role/BalanceSheetsParenthetical"/>
<link:roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#AcquisitionsInvestmentsAndLicensesTables" roleURI="http://opko.com/role/AcquisitionsInvestmentsAndLicensesTables"/>
<link:roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#AcquisitionAndInvestmentsDetails" roleURI="http://opko.com/role/AcquisitionAndInvestmentsDetails"/>
<link:roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#AcquisitionsInvestmentsAndLicensesDetails1" roleURI="http://opko.com/role/AcquisitionsInvestmentsAndLicensesDetails1"/>
<link:roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#AcquisitionAndInvestmentsDetails1" roleURI="http://opko.com/role/AcquisitionAndInvestmentsDetails1"/>
<link:roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#AcquisitionAndInvestmentsDetailsTextual" roleURI="http://opko.com/role/AcquisitionAndInvestmentsDetailsTextual"/>
<link:roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#FairValueMeasurementsDetails1" roleURI="http://opko.com/role/FairValueMeasurementsDetails1"/>
<link:roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#FairValueMeasurementsDetails" roleURI="http://opko.com/role/FairValueMeasurementsDetails"/>
<link:roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#FairValueMeasurementsDetails2" roleURI="http://opko.com/role/FairValueMeasurementsDetails2"/>
<link:roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#FairValueMeasurementsDetailsTextual" roleURI="http://opko.com/role/FairValueMeasurementsDetailsTextual"/>
<link:roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#DerivativeContractsDetails" roleURI="http://opko.com/role/DerivativeContractsDetails"/>
<link:roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#RelatedPartyTransactionsDetails" roleURI="http://opko.com/role/RelatedPartyTransactionsDetails"/>
<link:roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#CommitmentsAndContingenciesDetailsTextual" roleURI="http://opko.com/role/CommitmentsAndContingenciesDetailsTextual"/>
<link:roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#SegmentsDetails" roleURI="http://opko.com/role/SegmentsDetails"/>
<link:roleRef xlink:type="simple" xlink:href="opk-20120930.xsd#SegmentsDetailsTextual" roleURI="http://opko.com/role/SegmentsDetailsTextual"/>
<link:arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension" arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension"/>
<link:arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain" arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain"/>
<link:arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default" arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default"/>
<link:arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member" arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member"/>
<link:arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all" arcroleURI="http://xbrl.org/int/dim/arcrole/all"/>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/BalanceSheets" xlink:title="0110 - Statement - Condensed Consolidated Balance Sheets">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StatementTable" xlink:label="us-gaap_StatementTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="us-gaap_StatementClassOfStockAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_StatementTable" xlink:to="us-gaap_StatementClassOfStockAxis" order="1"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/BalanceSheets" xlink:title="0110 - Statement - Condensed Consolidated Balance Sheets">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="us-gaap_StatementClassOfStockAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="us-gaap_ClassOfStockDomain"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SeriesAPreferredStockMember" xlink:label="us-gaap_SeriesAPreferredStockMember"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SeriesCPreferredStockMember" xlink:label="us-gaap_SeriesCPreferredStockMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_StatementClassOfStockAxis" xlink:to="us-gaap_ClassOfStockDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockDomain" xlink:to="us-gaap_SeriesAPreferredStockMember" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockDomain" xlink:to="us-gaap_SeriesCPreferredStockMember" order="2"/>
</link:definitionLink>
<!-- Hypercube Definition (All) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/BalanceSheets" xlink:title="0110 - Statement - Condensed Consolidated Balance Sheets">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StatementTable" xlink:label="us-gaap_StatementTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StatementLineItems" xlink:label="us-gaap_StatementLineItems"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_StatementTable" order="2" xbrldt:closed="true" xbrldt:contextElement="segment"/>
</link:definitionLink>
<!-- Inheritance for Line Items: us-gaap:StatementLineItems -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/BalanceSheets" xlink:title="0110 - Statement - Condensed Consolidated Balance Sheets">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StatementLineItems" xlink:label="us-gaap_StatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AssetsAbstract" xlink:label="us-gaap_AssetsAbstract"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AssetsCurrentAbstract" xlink:label="us-gaap_AssetsCurrentAbstract"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_MarketableSecuritiesCurrent" xlink:label="us-gaap_MarketableSecuritiesCurrent"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="us-gaap_AccountsReceivableNetCurrent"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_InventoryNet" xlink:label="us-gaap_InventoryNet"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:label="us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrent" xlink:label="us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrent"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AssetsCurrent" xlink:label="us-gaap_AssetsCurrent"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="us-gaap_PropertyPlantAndEquipmentNet"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet" xlink:label="us-gaap_FiniteLivedIntangibleAssetsNet"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_Goodwill" xlink:label="us-gaap_Goodwill"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LongTermInvestments" xlink:label="us-gaap_LongTermInvestments"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OtherAssetsNoncurrent" xlink:label="us-gaap_OtherAssetsNoncurrent"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_Assets" xlink:label="us-gaap_Assets"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:label="us-gaap_LiabilitiesAndStockholdersEquityAbstract"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LiabilitiesCurrentAbstract" xlink:label="us-gaap_LiabilitiesCurrentAbstract"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AccountsPayableCurrent" xlink:label="us-gaap_AccountsPayableCurrent"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent" xlink:label="us-gaap_AccruedLiabilitiesCurrent"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LinesOfCreditCurrent" xlink:label="us-gaap_LinesOfCreditCurrent"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationCurrent" xlink:label="us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationCurrent"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LiabilitiesCurrent" xlink:label="us-gaap_LiabilitiesCurrent"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent" xlink:label="us-gaap_OtherLiabilitiesNoncurrent"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_Liabilities" xlink:label="us-gaap_Liabilities"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CommitmentsAndContingencies" xlink:label="us-gaap_CommitmentsAndContingencies"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_TemporaryEquityCarryingAmountAttributableToParent" xlink:label="us-gaap_TemporaryEquityCarryingAmountAttributableToParent"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StockholdersEquityAbstract" xlink:label="us-gaap_StockholdersEquityAbstract"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PreferredStockValue" xlink:label="us-gaap_PreferredStockValue"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CommonStockValue" xlink:label="us-gaap_CommonStockValue"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_TreasuryStockValue" xlink:label="us-gaap_TreasuryStockValue"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="us-gaap_AdditionalPaidInCapital"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="us-gaap_RetainedEarningsAccumulatedDeficit"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="us-gaap_StockholdersEquity"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="us-gaap_LiabilitiesAndStockholdersEquity"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_CashAndCashEquivalentsAtCarryingValue" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_MarketableSecuritiesCurrent" order="4"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_AccountsReceivableNetCurrent" order="5"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_InventoryNet" order="6"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_PrepaidExpenseAndOtherAssetsCurrent" order="7"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrent" order="8"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_AssetsCurrent" order="9"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_PropertyPlantAndEquipmentNet" order="10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_FiniteLivedIntangibleAssetsNet" order="11"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_Goodwill" order="12"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_LongTermInvestments" order="13"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_OtherAssetsNoncurrent" order="14"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_Assets" order="15"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_AccountsPayableCurrent" order="18"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_AccruedLiabilitiesCurrent" order="19"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_LinesOfCreditCurrent" order="20"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationCurrent" order="21"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_LiabilitiesCurrent" order="22"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_OtherLiabilitiesNoncurrent" order="23"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_Liabilities" order="24"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_CommitmentsAndContingencies" order="25"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_TemporaryEquityCarryingAmountAttributableToParent" order="26"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_PreferredStockValue" order="28"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_CommonStockValue" order="29"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_TreasuryStockValue" order="30"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_AdditionalPaidInCapital" order="31"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" order="32"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_RetainedEarningsAccumulatedDeficit" order="33"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_StockholdersEquity" order="34"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_LiabilitiesAndStockholdersEquity" order="35"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/BalanceSheets" xlink:title="0110 - Statement - Condensed Consolidated Balance Sheets">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="us-gaap_StatementClassOfStockAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="us-gaap_ClassOfStockDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_StatementClassOfStockAxis" xlink:to="us-gaap_ClassOfStockDomain" order="1"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/BalanceSheetsParenthetical" xlink:title="0111 - Statement - Condensed Consolidated Balance Sheets (Parenthetical) (unaudited)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StatementTable" xlink:label="us-gaap_StatementTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="us-gaap_StatementClassOfStockAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_StatementTable" xlink:to="us-gaap_StatementClassOfStockAxis" order="1"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/BalanceSheetsParenthetical" xlink:title="0111 - Statement - Condensed Consolidated Balance Sheets (Parenthetical) (unaudited)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="us-gaap_StatementClassOfStockAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="us-gaap_ClassOfStockDomain"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SeriesAPreferredStockMember" xlink:label="us-gaap_SeriesAPreferredStockMember"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SeriesCPreferredStockMember" xlink:label="us-gaap_SeriesCPreferredStockMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_StatementClassOfStockAxis" xlink:to="us-gaap_ClassOfStockDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockDomain" xlink:to="us-gaap_SeriesAPreferredStockMember" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockDomain" xlink:to="us-gaap_SeriesCPreferredStockMember" order="2"/>
</link:definitionLink>
<!-- Hypercube Definition (All) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/BalanceSheetsParenthetical" xlink:title="0111 - Statement - Condensed Consolidated Balance Sheets (Parenthetical) (unaudited)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StatementTable" xlink:label="us-gaap_StatementTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StatementLineItems" xlink:label="us-gaap_StatementLineItems"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_StatementTable" order="2" xbrldt:closed="true" xbrldt:contextElement="segment"/>
</link:definitionLink>
<!-- Inheritance for Line Items: us-gaap:StatementLineItems -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/BalanceSheetsParenthetical" xlink:title="0111 - Statement - Condensed Consolidated Balance Sheets (Parenthetical) (unaudited)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StatementLineItems" xlink:label="us-gaap_StatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_TemporaryEquityParOrStatedValuePerShare" xlink:label="us-gaap_TemporaryEquityParOrStatedValuePerShare"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_TemporaryEquitySharesAuthorized" xlink:label="us-gaap_TemporaryEquitySharesAuthorized"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_TemporaryEquitySharesIssued" xlink:label="us-gaap_TemporaryEquitySharesIssued"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_TemporaryEquitySharesOutstanding" xlink:label="us-gaap_TemporaryEquitySharesOutstanding"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_TemporaryEquityLiquidationPreference" xlink:label="us-gaap_TemporaryEquityLiquidationPreference"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PreferredStockParOrStatedValuePerShare" xlink:label="us-gaap_PreferredStockParOrStatedValuePerShare"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PreferredStockSharesAuthorized" xlink:label="us-gaap_PreferredStockSharesAuthorized"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PreferredStockSharesIssued" xlink:label="us-gaap_PreferredStockSharesIssued"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PreferredStockSharesOutstanding" xlink:label="us-gaap_PreferredStockSharesOutstanding"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare" xlink:label="us-gaap_CommonStockParOrStatedValuePerShare"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CommonStockSharesAuthorized" xlink:label="us-gaap_CommonStockSharesAuthorized"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="us-gaap_CommonStockSharesIssued"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_TreasuryStockShares" xlink:label="us-gaap_TreasuryStockShares"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_TemporaryEquityParOrStatedValuePerShare" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_TemporaryEquitySharesAuthorized" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_TemporaryEquitySharesIssued" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_TemporaryEquitySharesOutstanding" order="4"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_TemporaryEquityLiquidationPreference" order="5"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_PreferredStockParOrStatedValuePerShare" order="6"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_PreferredStockSharesAuthorized" order="7"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_PreferredStockSharesIssued" order="8"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_PreferredStockSharesOutstanding" order="9"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_CommonStockParOrStatedValuePerShare" order="10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_CommonStockSharesAuthorized" order="11"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_CommonStockSharesIssued" order="12"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_TreasuryStockShares" order="13"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/BalanceSheetsParenthetical" xlink:title="0111 - Statement - Condensed Consolidated Balance Sheets (Parenthetical) (unaudited)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="us-gaap_StatementClassOfStockAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="us-gaap_ClassOfStockDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_StatementClassOfStockAxis" xlink:to="us-gaap_ClassOfStockDomain" order="1"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionsInvestmentsAndLicensesTables" xlink:title="0505 - Disclosure - Acquisitions, Investments, and Licenses (Tables)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="us-gaap_BusinessAcquisitionAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:to="us-gaap_BusinessAcquisitionAxis" order="1"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionsInvestmentsAndLicensesTables" xlink:title="0505 - Disclosure - Acquisitions, Investments, and Licenses (Tables)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="us-gaap_BusinessAcquisitionAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="us-gaap_BusinessAcquisitionAcquireeDomain"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_AramaLaboratoriesAcquisitionMember" xlink:label="opk_AramaLaboratoriesAcquisitionMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_FinetechAcquisitionMember" xlink:label="opk_FinetechAcquisitionMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_ClarosDiagnosticsMember" xlink:label="opk_ClarosDiagnosticsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_BusinessAcquisitionAxis" xlink:to="us-gaap_BusinessAcquisitionAcquireeDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionAcquireeDomain" xlink:to="opk_AramaLaboratoriesAcquisitionMember" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionAcquireeDomain" xlink:to="opk_FinetechAcquisitionMember" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionAcquireeDomain" xlink:to="opk_ClarosDiagnosticsMember" order="3"/>
</link:definitionLink>
<!-- Hypercube Definition (All) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionsInvestmentsAndLicensesTables" xlink:title="0505 - Disclosure - Acquisitions, Investments, and Licenses (Tables)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="us-gaap_BusinessAcquisitionLineItems"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" order="2" xbrldt:closed="true" xbrldt:contextElement="segment"/>
</link:definitionLink>
<!-- Inheritance for Line Items: us-gaap:BusinessAcquisitionLineItems -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionsInvestmentsAndLicensesTables" xlink:title="0505 - Disclosure - Acquisitions, Investments, and Licenses (Tables)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="us-gaap_BusinessAcquisitionLineItems"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsTableTextBlock" xlink:label="us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsTableTextBlock"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_InvestmentIncomeTextBlock" xlink:label="us-gaap_InvestmentIncomeTextBlock"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsTableTextBlock" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_InvestmentIncomeTextBlock" order="2"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionsInvestmentsAndLicensesTables" xlink:title="0505 - Disclosure - Acquisitions, Investments, and Licenses (Tables)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="us-gaap_BusinessAcquisitionAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="us-gaap_BusinessAcquisitionAcquireeDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_BusinessAcquisitionAxis" xlink:to="us-gaap_BusinessAcquisitionAcquireeDomain" order="1"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetails" xlink:title="0605 - Disclosure - Acquisitions, Investments, and Licenses (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="us-gaap_BusinessAcquisitionAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:to="us-gaap_BusinessAcquisitionAxis" order="1"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetails" xlink:title="0605 - Disclosure - Acquisitions, Investments, and Licenses (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="us-gaap_BusinessAcquisitionAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="us-gaap_BusinessAcquisitionAcquireeDomain"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_AramaLaboratoriesAcquisitionMember" xlink:label="opk_AramaLaboratoriesAcquisitionMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_FinetechAcquisitionMember" xlink:label="opk_FinetechAcquisitionMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_BusinessAcquisitionAxis" xlink:to="us-gaap_BusinessAcquisitionAcquireeDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionAcquireeDomain" xlink:to="opk_AramaLaboratoriesAcquisitionMember" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionAcquireeDomain" xlink:to="opk_FinetechAcquisitionMember" order="2"/>
</link:definitionLink>
<!-- Hypercube Definition (All) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetails" xlink:title="0605 - Disclosure - Acquisitions, Investments, and Licenses (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="us-gaap_BusinessAcquisitionLineItems"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" order="2" xbrldt:closed="true" xbrldt:contextElement="segment"/>
</link:definitionLink>
<!-- Inheritance for Line Items: us-gaap:BusinessAcquisitionLineItems -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetails" xlink:title="0605 - Disclosure - Acquisitions, Investments, and Licenses (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="us-gaap_BusinessAcquisitionLineItems"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationAbstract" xlink:label="us-gaap_BusinessAcquisitionPurchasePriceAllocationAbstract"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssets" xlink:label="us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssets"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetAbstract" xlink:label="opk_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetAbstract"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BusinessAcquisitionPurchasePriceAllocationCustomerRelationships" xlink:label="opk_BusinessAcquisitionPurchasePriceAllocationCustomerRelationships"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BusinessAcquisitionPurchasePriceAllocationTechnology" xlink:label="opk_BusinessAcquisitionPurchasePriceAllocationTechnology"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BusinessAcquisitionPurchasePriceInProcessResearchAndDevelopmentExpensed" xlink:label="opk_BusinessAcquisitionPurchasePriceInProcessResearchAndDevelopmentExpensed"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BusinessAcquisitionPurchasePriceAllocationProductRegistrations" xlink:label="opk_BusinessAcquisitionPurchasePriceAllocationProductRegistrations"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BusinessAcquisitionPurchasePriceAllocationCovenantsNotToCompete" xlink:label="opk_BusinessAcquisitionPurchasePriceAllocationCovenantsNotToCompete"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BusinessAcquisitionPurchasePriceAllocationTradeName" xlink:label="opk_BusinessAcquisitionPurchasePriceAllocationTradeName"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill" xlink:label="us-gaap_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationGoodwillAmount" xlink:label="us-gaap_BusinessAcquisitionPurchasePriceAllocationGoodwillAmount"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationPropertyPlantAndEquipment" xlink:label="us-gaap_BusinessAcquisitionPurchasePriceAllocationPropertyPlantAndEquipment"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationOtherAssets" xlink:label="us-gaap_BusinessAcquisitionPurchasePriceAllocationOtherAssets"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayableAndAccruedExpenses" xlink:label="opk_BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayableAndAccruedExpenses"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationDeferredIncomeTaxesAssetLiabilityNet" xlink:label="us-gaap_BusinessAcquisitionPurchasePriceAllocationDeferredIncomeTaxesAssetLiabilityNet"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BusinessAcquisitionPurchasePriceAllocationDeferredPayment" xlink:label="opk_BusinessAcquisitionPurchasePriceAllocationDeferredPayment"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationNotesPayableAndLongTermDebt" xlink:label="us-gaap_BusinessAcquisitionPurchasePriceAllocationNotesPayableAndLongTermDebt"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionContingentConsiderationAtFairValue" xlink:label="us-gaap_BusinessAcquisitionContingentConsiderationAtFairValue"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:label="us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssets" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_BusinessAcquisitionPurchasePriceAllocationCustomerRelationships" order="4"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_BusinessAcquisitionPurchasePriceAllocationTechnology" order="5"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_BusinessAcquisitionPurchasePriceInProcessResearchAndDevelopmentExpensed" order="6"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_BusinessAcquisitionPurchasePriceAllocationProductRegistrations" order="7"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_BusinessAcquisitionPurchasePriceAllocationCovenantsNotToCompete" order="8"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_BusinessAcquisitionPurchasePriceAllocationTradeName" order="9"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill" order="10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionPurchasePriceAllocationGoodwillAmount" order="11"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionPurchasePriceAllocationPropertyPlantAndEquipment" order="12"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionPurchasePriceAllocationOtherAssets" order="13"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayableAndAccruedExpenses" order="14"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionPurchasePriceAllocationDeferredIncomeTaxesAssetLiabilityNet" order="15"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_BusinessAcquisitionPurchasePriceAllocationDeferredPayment" order="16"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionPurchasePriceAllocationNotesPayableAndLongTermDebt" order="17"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionContingentConsiderationAtFairValue" order="18"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" order="19"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetails" xlink:title="0605 - Disclosure - Acquisitions, Investments, and Licenses (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="us-gaap_BusinessAcquisitionAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="us-gaap_BusinessAcquisitionAcquireeDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_BusinessAcquisitionAxis" xlink:to="us-gaap_BusinessAcquisitionAcquireeDomain" order="1"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionsInvestmentsAndLicensesDetails1" xlink:title="06051 - Disclosure - Acquisitions, Investments, and Licenses (Details 1)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="us-gaap_BusinessAcquisitionAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:to="us-gaap_BusinessAcquisitionAxis" order="1"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionsInvestmentsAndLicensesDetails1" xlink:title="06051 - Disclosure - Acquisitions, Investments, and Licenses (Details 1)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="us-gaap_BusinessAcquisitionAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="us-gaap_BusinessAcquisitionAcquireeDomain"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_ClarosDiagnosticsMember" xlink:label="opk_ClarosDiagnosticsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_BusinessAcquisitionAxis" xlink:to="us-gaap_BusinessAcquisitionAcquireeDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionAcquireeDomain" xlink:to="opk_ClarosDiagnosticsMember" order="1"/>
</link:definitionLink>
<!-- Hypercube Definition (All) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionsInvestmentsAndLicensesDetails1" xlink:title="06051 - Disclosure - Acquisitions, Investments, and Licenses (Details 1)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="us-gaap_BusinessAcquisitionLineItems"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" order="2" xbrldt:closed="true" xbrldt:contextElement="segment"/>
</link:definitionLink>
<!-- Inheritance for Line Items: us-gaap:BusinessAcquisitionLineItems -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionsInvestmentsAndLicensesDetails1" xlink:title="06051 - Disclosure - Acquisitions, Investments, and Licenses (Details 1)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="us-gaap_BusinessAcquisitionLineItems"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationAbstract" xlink:label="us-gaap_BusinessAcquisitionPurchasePriceAllocationAbstract"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssets" xlink:label="us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssets"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BusinessAcquisitionPurchasePriceAllocationTechnology" xlink:label="opk_BusinessAcquisitionPurchasePriceAllocationTechnology"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationGoodwillAmount" xlink:label="us-gaap_BusinessAcquisitionPurchasePriceAllocationGoodwillAmount"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationEquipment" xlink:label="us-gaap_BusinessAcquisitionPurchasePriceAllocationEquipment"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationOtherAssets" xlink:label="us-gaap_BusinessAcquisitionPurchasePriceAllocationOtherAssets"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayableAndAccruedExpenses" xlink:label="opk_BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayableAndAccruedExpenses"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationDeferredIncomeTaxesAssetLiabilityNet" xlink:label="us-gaap_BusinessAcquisitionPurchasePriceAllocationDeferredIncomeTaxesAssetLiabilityNet"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionContingentConsiderationAtFairValue" xlink:label="us-gaap_BusinessAcquisitionContingentConsiderationAtFairValue"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:label="us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssets" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_BusinessAcquisitionPurchasePriceAllocationTechnology" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionPurchasePriceAllocationGoodwillAmount" order="4"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionPurchasePriceAllocationEquipment" order="5"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionPurchasePriceAllocationOtherAssets" order="6"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccountsPayableAndAccruedExpenses" order="7"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionPurchasePriceAllocationDeferredIncomeTaxesAssetLiabilityNet" order="8"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionContingentConsiderationAtFairValue" order="9"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" order="10"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionsInvestmentsAndLicensesDetails1" xlink:title="06051 - Disclosure - Acquisitions, Investments, and Licenses (Details 1)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="us-gaap_BusinessAcquisitionAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="us-gaap_BusinessAcquisitionAcquireeDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_BusinessAcquisitionAxis" xlink:to="us-gaap_BusinessAcquisitionAcquireeDomain" order="1"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetails1" xlink:title="06052 - Disclosure - Acquisitions, Investments, and Licenses (Details 2)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:label="us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis" xlink:label="us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:to="us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis" order="1"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetails1" xlink:title="06052 - Disclosure - Acquisitions, Investments, and Licenses (Details 2)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis" xlink:label="us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassificationOfVariableInterestEntityDomain" xlink:label="us-gaap_ClassificationOfVariableInterestEntityDomain"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:label="us-gaap_VariableInterestEntityPrimaryBeneficiaryMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_CocrystalMember" xlink:label="opk_CocrystalMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_NeovascMember" xlink:label="opk_NeovascMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_FabrusMember" xlink:label="opk_FabrusMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_SorrentoMember" xlink:label="opk_SorrentoMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BiozoneMember" xlink:label="opk_BiozoneMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BiozonePharmaceuticalsIncMember" xlink:label="opk_BiozonePharmaceuticalsIncMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_ChromaDexMember" xlink:label="opk_ChromaDexMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_NeovascOptionsMember" xlink:label="opk_NeovascOptionsMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_TesaroMember" xlink:label="opk_TesaroMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis" xlink:to="us-gaap_ClassificationOfVariableInterestEntityDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassificationOfVariableInterestEntityDomain" xlink:to="us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:to="opk_CocrystalMember" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:to="opk_NeovascMember" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:to="opk_FabrusMember" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:to="opk_SorrentoMember" order="4"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:to="opk_BiozoneMember" order="5"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:to="opk_BiozonePharmaceuticalsIncMember" order="6"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:to="opk_ChromaDexMember" order="7"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:to="opk_NeovascOptionsMember" order="8"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:to="opk_TesaroMember" order="9"/>
</link:definitionLink>
<!-- Hypercube Definition (All) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetails1" xlink:title="06052 - Disclosure - Acquisitions, Investments, and Licenses (Details 2)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:label="us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StatementLineItems" xlink:label="us-gaap_StatementLineItems"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" order="2" xbrldt:closed="true" xbrldt:contextElement="segment"/>
</link:definitionLink>
<!-- Inheritance for Line Items: us-gaap:StatementLineItems -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetails1" xlink:title="06052 - Disclosure - Acquisitions, Investments, and Licenses (Details 2)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StatementLineItems" xlink:label="us-gaap_StatementLineItems"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_UnrealizedGainLossOnInvestmentsAbstract" xlink:label="us-gaap_UnrealizedGainLossOnInvestmentsAbstract"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_EquityInvestmentYear" xlink:label="opk_EquityInvestmentYear"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_VariableInterestEntityEntityAccountingMethod" xlink:label="opk_VariableInterestEntityEntityAccountingMethod"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:label="us-gaap_EquityMethodInvestmentOwnershipPercentage"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_VariableInterestEntityEntityMaximumLossExposureAmount" xlink:label="us-gaap_VariableInterestEntityEntityMaximumLossExposureAmount"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_EquityMethodInvestmentUnderlyingEquityInNetAssets" xlink:label="us-gaap_EquityMethodInvestmentUnderlyingEquityInNetAssets"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_VariableInterestEntityEntityAccumulatedLossesInInvestees" xlink:label="opk_VariableInterestEntityEntityAccumulatedLossesInInvestees"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_VariableInterestEntityEntityMaximumNetLossExposureAmount" xlink:label="opk_VariableInterestEntityEntityMaximumNetLossExposureAmount"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_UnrealizedGainOnInvestmentsOptionsAndWarrants" xlink:label="opk_UnrealizedGainOnInvestmentsOptionsAndWarrants"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AvailableForSaleSecuritiesCurrent" xlink:label="us-gaap_AvailableForSaleSecuritiesCurrent"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AvailableForSaleSecuritiesEquitySecurities" xlink:label="us-gaap_AvailableForSaleSecuritiesEquitySecurities"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="opk_EquityInvestmentYear" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="opk_VariableInterestEntityEntityAccountingMethod" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_EquityMethodInvestmentOwnershipPercentage" order="4"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_VariableInterestEntityEntityMaximumLossExposureAmount" order="5"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_EquityMethodInvestmentUnderlyingEquityInNetAssets" order="6"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="opk_VariableInterestEntityEntityAccumulatedLossesInInvestees" order="7"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="opk_VariableInterestEntityEntityMaximumNetLossExposureAmount" order="8"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="opk_UnrealizedGainOnInvestmentsOptionsAndWarrants" order="9"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_AvailableForSaleSecuritiesCurrent" order="10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_AvailableForSaleSecuritiesEquitySecurities" order="11"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetails1" xlink:title="06052 - Disclosure - Acquisitions, Investments, and Licenses (Details 2)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis" xlink:label="us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassificationOfVariableInterestEntityDomain" xlink:label="us-gaap_ClassificationOfVariableInterestEntityDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis" xlink:to="us-gaap_ClassificationOfVariableInterestEntityDomain" order="1"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetailsTextual" xlink:title="06053 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="us-gaap_BusinessAcquisitionAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:to="us-gaap_BusinessAcquisitionAxis" order="1"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetailsTextual" xlink:title="06053 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="us-gaap_BusinessAcquisitionAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="us-gaap_BusinessAcquisitionAcquireeDomain"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_AlsAcquisitionMember" xlink:label="opk_AlsAcquisitionMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_FinetechAcquisitionMember" xlink:label="opk_FinetechAcquisitionMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_ClarosDiagnosticsMember" xlink:label="opk_ClarosDiagnosticsMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_FarmadietAcquisitionMember" xlink:label="opk_FarmadietAcquisitionMember"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:label="us-gaap_VariableInterestEntityPrimaryBeneficiaryMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_FabrusLlcMember" xlink:label="opk_FabrusLlcMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_FabrusAndDrsFrostMember" xlink:label="opk_FabrusAndDrsFrostMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_CocrystalDiscoveryIncMember" xlink:label="opk_CocrystalDiscoveryIncMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_BusinessAcquisitionAxis" xlink:to="us-gaap_BusinessAcquisitionAcquireeDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionAcquireeDomain" xlink:to="opk_AlsAcquisitionMember" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionAcquireeDomain" xlink:to="opk_FinetechAcquisitionMember" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionAcquireeDomain" xlink:to="opk_ClarosDiagnosticsMember" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionAcquireeDomain" xlink:to="opk_FarmadietAcquisitionMember" order="4"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionAcquireeDomain" xlink:to="us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" order="5"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:to="opk_FabrusLlcMember" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:to="opk_FabrusAndDrsFrostMember" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:to="opk_CocrystalDiscoveryIncMember" order="3"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetailsTextual" xlink:title="06053 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ProductOrServiceAxis" xlink:label="us-gaap_ProductOrServiceAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:to="us-gaap_ProductOrServiceAxis" order="2"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetailsTextual" xlink:title="06053 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ProductOrServiceAxis" xlink:label="us-gaap_ProductOrServiceAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="us-gaap_ProductsAndServicesDomain"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_ProductInDevelopmentMember" xlink:label="opk_ProductInDevelopmentMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_ProductOrServiceAxis" xlink:to="us-gaap_ProductsAndServicesDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ProductsAndServicesDomain" xlink:to="opk_ProductInDevelopmentMember" order="1"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetailsTextual" xlink:title="06053 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:to="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" order="3"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetailsTextual" xlink:title="06053 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="us-gaap_RelatedPartyDomain"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_GammaTrustMember" xlink:label="opk_GammaTrustMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_TevaPharmaceuticalIndustriesLtdMember" xlink:label="opk_TevaPharmaceuticalIndustriesLtdMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_ChromadexCorporationMember" xlink:label="opk_ChromadexCorporationMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BiozonePharmaceuticalsIncMember" xlink:label="opk_BiozonePharmaceuticalsIncMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_SorrentoMember" xlink:label="opk_SorrentoMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_CocrystalMember" xlink:label="opk_CocrystalMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_FabrusMember" xlink:label="opk_FabrusMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_NeovascMember" xlink:label="opk_NeovascMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_TesaroMember" xlink:label="opk_TesaroMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:to="us-gaap_RelatedPartyDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_GammaTrustMember" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_TevaPharmaceuticalIndustriesLtdMember" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_ChromadexCorporationMember" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_BiozonePharmaceuticalsIncMember" order="4"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_SorrentoMember" order="5"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_CocrystalMember" order="6"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_FabrusMember" order="7"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_NeovascMember" order="8"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_TesaroMember" order="9"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetailsTextual" xlink:title="06053 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:label="us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:to="us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" order="4"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetailsTextual" xlink:title="06053 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:label="us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_EquityMethodInvesteeNameDomain" xlink:label="us-gaap_EquityMethodInvesteeNameDomain"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_NeovascIncMember" xlink:label="opk_NeovascIncMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_SorrentoTherapeuticsIncMember" xlink:label="opk_SorrentoTherapeuticsIncMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:to="us-gaap_EquityMethodInvesteeNameDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_EquityMethodInvesteeNameDomain" xlink:to="opk_NeovascIncMember" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_EquityMethodInvesteeNameDomain" xlink:to="opk_SorrentoTherapeuticsIncMember" order="2"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetailsTextual" xlink:title="06053 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis" xlink:label="us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:to="us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis" order="5"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetailsTextual" xlink:title="06053 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis" xlink:label="us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassificationOfVariableInterestEntityDomain" xlink:label="us-gaap_ClassificationOfVariableInterestEntityDomain"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:label="us-gaap_VariableInterestEntityPrimaryBeneficiaryMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_FabrusLlcMember" xlink:label="opk_FabrusLlcMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_FabrusAndDrsFrostMember" xlink:label="opk_FabrusAndDrsFrostMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_CocrystalDiscoveryIncMember" xlink:label="opk_CocrystalDiscoveryIncMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis" xlink:to="us-gaap_ClassificationOfVariableInterestEntityDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassificationOfVariableInterestEntityDomain" xlink:to="us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" order="1"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetailsTextual" xlink:title="06053 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfCostMethodInvestmentsAxis" xlink:label="us-gaap_ScheduleOfCostMethodInvestmentsAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:to="us-gaap_ScheduleOfCostMethodInvestmentsAxis" order="6"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetailsTextual" xlink:title="06053 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfCostMethodInvestmentsAxis" xlink:label="us-gaap_ScheduleOfCostMethodInvestmentsAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" xlink:label="us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_InvestmentsMember" xlink:label="us-gaap_InvestmentsMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_TesaroMember" xlink:label="opk_TesaroMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_HsiaoAndLernerMember" xlink:label="opk_HsiaoAndLernerMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_ScheduleOfCostMethodInvestmentsAxis" xlink:to="us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" xlink:to="us-gaap_InvestmentsMember" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" xlink:to="opk_TesaroMember" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" xlink:to="opk_HsiaoAndLernerMember" order="3"/>
</link:definitionLink>
<!-- Hypercube Definition (All) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetailsTextual" xlink:title="06053 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="us-gaap_BusinessAcquisitionLineItems"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" order="7" xbrldt:closed="true" xbrldt:contextElement="segment"/>
</link:definitionLink>
<!-- Inheritance for Line Items: us-gaap:BusinessAcquisitionLineItems -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetailsTextual" xlink:title="06053 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="us-gaap_BusinessAcquisitionLineItems"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_AcquisitionAndInvestmentsTextualAbstract" xlink:label="opk_AcquisitionAndInvestmentsTextualAbstract"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssetsCashAndCashEquivalents" xlink:label="us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssetsCashAndCashEquivalents"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:label="us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionCostOfAcquiredEntityCashPaid" xlink:label="us-gaap_BusinessAcquisitionCostOfAcquiredEntityCashPaid"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_PortionOfBusinessAcquisitionCostOfAcquiredEntityCashPaid" xlink:label="opk_PortionOfBusinessAcquisitionCostOfAcquiredEntityCashPaid"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_PortionOfDeferredPaymentPaidAtOurOptionInCashOrShares" xlink:label="opk_PortionOfDeferredPaymentPaidAtOurOptionInCashOrShares"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_PortionOfPaidOnFirstAnniversaryOfClosingDate" xlink:label="opk_PortionOfPaidOnFirstAnniversaryOfClosingDate"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_PortionOfPaidInEighteenMonthsAfterClosingDate" xlink:label="opk_PortionOfPaidInEighteenMonthsAfterClosingDate"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_DeferredAcquisitionPaymentsNetOfDiscount" xlink:label="opk_DeferredAcquisitionPaymentsNetOfDiscount"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_DeferredAcquisitionPaymentsDiscount" xlink:label="opk_DeferredAcquisitionPaymentsDiscount"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_DeferredPaymentToSatisfyIndemnityClaims" xlink:label="opk_DeferredPaymentToSatisfyIndemnityClaims"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_NumberOfTradingDays" xlink:label="opk_NumberOfTradingDays"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_NumberOfAncillaryTransaction" xlink:label="opk_NumberOfAncillaryTransaction"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_AncillaryTransactionDetails" xlink:label="opk_AncillaryTransactionDetails"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="us-gaap_CommonStockSharesIssued"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_NumberOfSharesIssuedAtClosingDate" xlink:label="opk_NumberOfSharesIssuedAtClosingDate"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_NumberOfSharesIssuedUponAchievingCertainMilestone" xlink:label="opk_NumberOfSharesIssuedUponAchievingCertainMilestone"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_MinorityInterestOwnershipPercentageByParent" xlink:label="us-gaap_MinorityInterestOwnershipPercentageByParent"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_MinorityInterestOwnershipPercentageByNoncontrollingOwners" xlink:label="us-gaap_MinorityInterestOwnershipPercentageByNoncontrollingOwners"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_PortionOfAmountPayableOnCashOrSharesOnAchievingMilestones" xlink:label="opk_PortionOfAmountPayableOnCashOrSharesOnAchievingMilestones"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_AmountPayableOnCashOrSharesOnAchievingMilestones" xlink:label="opk_AmountPayableOnCashOrSharesOnAchievingMilestones"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BusinessAcquisitionCostOfAcquiredEntityCashPaidThroughEscrowAccount" xlink:label="opk_BusinessAcquisitionCostOfAcquiredEntityCashPaidThroughEscrowAccount"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionCostOfAcquiredEntityTransactionCosts" xlink:label="us-gaap_BusinessAcquisitionCostOfAcquiredEntityTransactionCosts"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionCostOfAcquiredEntityLiabilitiesIncurred" xlink:label="us-gaap_BusinessAcquisitionCostOfAcquiredEntityLiabilitiesIncurred"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BusinessAcquisitionCostOfAcquiredEntityLiabilitiesIncurredPaidAtClosing" xlink:label="opk_BusinessAcquisitionCostOfAcquiredEntityLiabilitiesIncurredPaidAtClosing"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuable" xlink:label="us-gaap_BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuable"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BusinessAcquisitionCostOfAcquiredEntityCommonStockIssuedMarketValuePerShare" xlink:label="opk_BusinessAcquisitionCostOfAcquiredEntityCommonStockIssuedMarketValuePerShare"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_AverageClosingSalesPricePerShareOfCommonStock" xlink:label="opk_AverageClosingSalesPricePerShareOfCommonStock"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_ValueOfStockConsiderationHeldInEscrowAccount" xlink:label="opk_ValueOfStockConsiderationHeldInEscrowAccount"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_ClaimAgainstEscrowForUndisclosedLiabilities" xlink:label="opk_ClaimAgainstEscrowForUndisclosedLiabilities"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AdditionalPaidInCapitalCommonStock" xlink:label="us-gaap_AdditionalPaidInCapitalCommonStock"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_WorkingCapitalSurplus" xlink:label="opk_WorkingCapitalSurplus"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuableParValue" xlink:label="opk_BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuableParValue"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_NumberOfSharesWarrantsAcquiredInEquityMethodInvestment" xlink:label="opk_NumberOfSharesWarrantsAcquiredInEquityMethodInvestment"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_PromissoryNotesMaturityDate" xlink:label="opk_PromissoryNotesMaturityDate"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_ExercisePriceOfWarrantsAcquiredInEquityMethodInvestment" xlink:label="opk_ExercisePriceOfWarrantsAcquiredInEquityMethodInvestment"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_FairValueOfWarrantsAcquiredInEquityMethodInvestment" xlink:label="opk_FairValueOfWarrantsAcquiredInEquityMethodInvestment"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrantDateIntrinsicValue" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrantDateIntrinsicValue"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_NumberOfYearsOverWhichRevenueWillBeRecognized" xlink:label="opk_NumberOfYearsOverWhichRevenueWillBeRecognized"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrantDateFairValue" xlink:label="opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrantDateFairValue"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:label="us-gaap_EquityMethodInvestmentOwnershipPercentage"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BusinessAcquisitionPurchaseOfCommonStockShares" xlink:label="opk_BusinessAcquisitionPurchaseOfCommonStockShares"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_FinancingForVariableInterestEntities" xlink:label="opk_FinancingForVariableInterestEntities"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_EquityInvestment" xlink:label="opk_EquityInvestment"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BusinessAcquisitionPurchaseOfSeriesPreferredStock" xlink:label="opk_BusinessAcquisitionPurchaseOfSeriesPreferredStock"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_VariableInterestEntityOwnershipPercentage" xlink:label="us-gaap_VariableInterestEntityOwnershipPercentage"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_WarrantsDuration" xlink:label="opk_WarrantsDuration"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BiozonePharmaceuticalsWarrantsExercised" xlink:label="opk_BiozonePharmaceuticalsWarrantsExercised"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SharePrice" xlink:label="us-gaap_SharePrice"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ProceedsFromIssuanceOfPrivatePlacement" xlink:label="us-gaap_ProceedsFromIssuanceOfPrivatePlacement"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationNotesPayableAndLongTermDebt" xlink:label="us-gaap_BusinessAcquisitionPurchasePriceAllocationNotesPayableAndLongTermDebt"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_WarrantsToPurchaseCommonShares" xlink:label="opk_WarrantsToPurchaseCommonShares"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_OwnershipPercentageOfVariableInterestEntityByRelatedPartyGroup" xlink:label="opk_OwnershipPercentageOfVariableInterestEntityByRelatedPartyGroup"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_UnrealizedGainOnWarrants" xlink:label="opk_UnrealizedGainOnWarrants"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_UnrealizedGainLossOnDerivatives" xlink:label="us-gaap_UnrealizedGainLossOnDerivatives"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AvailableforsaleSecuritiesGrossUnrealizedGain" xlink:label="us-gaap_AvailableforsaleSecuritiesGrossUnrealizedGain"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_OwnershipPercentageOfVariablesInterestEntity" xlink:label="opk_OwnershipPercentageOfVariablesInterestEntity"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_InvestmentInVariableInterestEntities" xlink:label="opk_InvestmentInVariableInterestEntities"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_PercentageInBoardOfManagers" xlink:label="opk_PercentageInBoardOfManagers"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_EquityMethodInvestments" xlink:label="us-gaap_EquityMethodInvestments"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets" xlink:label="us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilities" xlink:label="us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilities"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_EquityMethodInvestmentSummarizedFinancialInformationNetIncomeLoss" xlink:label="us-gaap_EquityMethodInvestmentSummarizedFinancialInformationNetIncomeLoss"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_AdditionalAmountPaidForLegalRegistration" xlink:label="opk_AdditionalAmountPaidForLegalRegistration"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssetsCashAndCashEquivalents" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionCostOfAcquiredEntityCashPaid" order="4"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_PortionOfBusinessAcquisitionCostOfAcquiredEntityCashPaid" order="5"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_PortionOfDeferredPaymentPaidAtOurOptionInCashOrShares" order="6"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_PortionOfPaidOnFirstAnniversaryOfClosingDate" order="7"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_PortionOfPaidInEighteenMonthsAfterClosingDate" order="8"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_DeferredAcquisitionPaymentsNetOfDiscount" order="9"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_DeferredAcquisitionPaymentsDiscount" order="10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_DeferredPaymentToSatisfyIndemnityClaims" order="11"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_NumberOfTradingDays" order="12"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_NumberOfAncillaryTransaction" order="13"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_AncillaryTransactionDetails" order="14"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_CommonStockSharesIssued" order="15"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_NumberOfSharesIssuedAtClosingDate" order="16"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_NumberOfSharesIssuedUponAchievingCertainMilestone" order="17"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_MinorityInterestOwnershipPercentageByParent" order="18"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_MinorityInterestOwnershipPercentageByNoncontrollingOwners" order="19"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_PortionOfAmountPayableOnCashOrSharesOnAchievingMilestones" order="20"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_AmountPayableOnCashOrSharesOnAchievingMilestones" order="21"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_BusinessAcquisitionCostOfAcquiredEntityCashPaidThroughEscrowAccount" order="22"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionCostOfAcquiredEntityTransactionCosts" order="23"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionCostOfAcquiredEntityLiabilitiesIncurred" order="24"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_BusinessAcquisitionCostOfAcquiredEntityLiabilitiesIncurredPaidAtClosing" order="25"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuable" order="26"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_BusinessAcquisitionCostOfAcquiredEntityCommonStockIssuedMarketValuePerShare" order="27"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_AverageClosingSalesPricePerShareOfCommonStock" order="28"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_ValueOfStockConsiderationHeldInEscrowAccount" order="29"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_ClaimAgainstEscrowForUndisclosedLiabilities" order="30"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_AdditionalPaidInCapitalCommonStock" order="31"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_WorkingCapitalSurplus" order="32"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuableParValue" order="33"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_NumberOfSharesWarrantsAcquiredInEquityMethodInvestment" order="34"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_PromissoryNotesMaturityDate" order="35"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_ExercisePriceOfWarrantsAcquiredInEquityMethodInvestment" order="36"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_FairValueOfWarrantsAcquiredInEquityMethodInvestment" order="37"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrantDateIntrinsicValue" order="38"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1" order="39"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_NumberOfYearsOverWhichRevenueWillBeRecognized" order="40"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrantDateFairValue" order="41"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_EquityMethodInvestmentOwnershipPercentage" order="42"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_BusinessAcquisitionPurchaseOfCommonStockShares" order="43"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_FinancingForVariableInterestEntities" order="44"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_EquityInvestment" order="45"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_BusinessAcquisitionPurchaseOfSeriesPreferredStock" order="46"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_VariableInterestEntityOwnershipPercentage" order="47"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_WarrantsDuration" order="48"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_BiozonePharmaceuticalsWarrantsExercised" order="49"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_SharePrice" order="50"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_ProceedsFromIssuanceOfPrivatePlacement" order="51"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionPurchasePriceAllocationNotesPayableAndLongTermDebt" order="52"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_WarrantsToPurchaseCommonShares" order="53"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_OwnershipPercentageOfVariableInterestEntityByRelatedPartyGroup" order="54"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_UnrealizedGainOnWarrants" order="55"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_UnrealizedGainLossOnDerivatives" order="56"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_AvailableforsaleSecuritiesGrossUnrealizedGain" order="57"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_OwnershipPercentageOfVariablesInterestEntity" order="58"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_InvestmentInVariableInterestEntities" order="59"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross" order="60"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_PercentageInBoardOfManagers" order="61"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_EquityMethodInvestments" order="62"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets" order="63"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilities" order="64"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_EquityMethodInvestmentSummarizedFinancialInformationNetIncomeLoss" order="65"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="opk_AdditionalAmountPaidForLegalRegistration" order="66"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetailsTextual" xlink:title="06053 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="us-gaap_BusinessAcquisitionAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="us-gaap_BusinessAcquisitionAcquireeDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_BusinessAcquisitionAxis" xlink:to="us-gaap_BusinessAcquisitionAcquireeDomain" order="1"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetailsTextual" xlink:title="06053 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ProductOrServiceAxis" xlink:label="us-gaap_ProductOrServiceAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="us-gaap_ProductsAndServicesDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_ProductOrServiceAxis" xlink:to="us-gaap_ProductsAndServicesDomain" order="2"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetailsTextual" xlink:title="06053 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="us-gaap_RelatedPartyDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:to="us-gaap_RelatedPartyDomain" order="3"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetailsTextual" xlink:title="06053 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:label="us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_EquityMethodInvesteeNameDomain" xlink:label="us-gaap_EquityMethodInvesteeNameDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:to="us-gaap_EquityMethodInvesteeNameDomain" order="4"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetailsTextual" xlink:title="06053 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis" xlink:label="us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ClassificationOfVariableInterestEntityDomain" xlink:label="us-gaap_ClassificationOfVariableInterestEntityDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis" xlink:to="us-gaap_ClassificationOfVariableInterestEntityDomain" order="5"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/AcquisitionAndInvestmentsDetailsTextual" xlink:title="06053 - Disclosure - Acquisitions, Investments, and Licenses (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfCostMethodInvestmentsAxis" xlink:label="us-gaap_ScheduleOfCostMethodInvestmentsAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" xlink:label="us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_ScheduleOfCostMethodInvestmentsAxis" xlink:to="us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" order="6"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails1" xlink:title="0607 - Disclosure - Fair Value Measurements (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueByBalanceSheetGroupingTable" xlink:label="us-gaap_FairValueByBalanceSheetGroupingTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_FairValueByBalanceSheetGroupingTable" xlink:to="us-gaap_FairValueByFairValueHierarchyLevelAxis" order="1"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails1" xlink:title="0607 - Disclosure - Fair Value Measurements (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_CommonStockInvestmentsMember" xlink:label="opk_CommonStockInvestmentsMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BzneNoteAndBeneficialConversationFeatureMember" xlink:label="opk_BzneNoteAndBeneficialConversationFeatureMember"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StockOptionsMember" xlink:label="us-gaap_StockOptionsMember"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_WarrantMember" xlink:label="us-gaap_WarrantMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:to="us-gaap_FairValueMeasurementsFairValueHierarchyDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:to="opk_CommonStockInvestmentsMember" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:to="opk_BzneNoteAndBeneficialConversationFeatureMember" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:to="us-gaap_StockOptionsMember" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:to="us-gaap_WarrantMember" order="4"/>
</link:definitionLink>
<!-- Hypercube Definition (All) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails1" xlink:title="0607 - Disclosure - Fair Value Measurements (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueByBalanceSheetGroupingTable" xlink:label="us-gaap_FairValueByBalanceSheetGroupingTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems" xlink:label="us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems" xlink:to="us-gaap_FairValueByBalanceSheetGroupingTable" order="2" xbrldt:closed="true" xbrldt:contextElement="segment"/>
</link:definitionLink>
<!-- Inheritance for Line Items: us-gaap:FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails1" xlink:title="0607 - Disclosure - Fair Value Measurements (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems" xlink:label="us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AvailableForSaleSecuritiesBalanceSheetReportedAmountsAbstract" xlink:label="us-gaap_AvailableForSaleSecuritiesBalanceSheetReportedAmountsAbstract"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAmortizedCost" xlink:label="us-gaap_AvailableForSaleSecuritiesAmortizedCost"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AvailableforsaleSecuritiesGrossUnrealizedGain" xlink:label="us-gaap_AvailableforsaleSecuritiesGrossUnrealizedGain"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLosses1" xlink:label="us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLosses1"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AvailableForSaleSecuritiesGrossUnrealizedGainLoss" xlink:label="us-gaap_AvailableForSaleSecuritiesGrossUnrealizedGainLoss"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AvailableForSaleSecuritiesFairValueDisclosure" xlink:label="us-gaap_AvailableForSaleSecuritiesFairValueDisclosure"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems" xlink:to="us-gaap_AvailableForSaleSecuritiesAmortizedCost" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems" xlink:to="us-gaap_AvailableforsaleSecuritiesGrossUnrealizedGain" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems" xlink:to="us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLosses1" order="4"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems" xlink:to="us-gaap_AvailableForSaleSecuritiesGrossUnrealizedGainLoss" order="5"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems" xlink:to="us-gaap_AvailableForSaleSecuritiesFairValueDisclosure" order="6"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails1" xlink:title="0607 - Disclosure - Fair Value Measurements (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:to="us-gaap_FairValueMeasurementsFairValueHierarchyDomain" order="1"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails" xlink:title="06071 - Disclosure - Fair Value Measurements (Details 1)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfCashAndCashEquivalentsTable" xlink:label="us-gaap_ScheduleOfCashAndCashEquivalentsTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="us-gaap_FairValueByMeasurementFrequencyAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_ScheduleOfCashAndCashEquivalentsTable" xlink:to="us-gaap_FairValueByMeasurementFrequencyAxis" order="1"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails" xlink:title="06071 - Disclosure - Fair Value Measurements (Details 1)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="us-gaap_FairValueByMeasurementFrequencyAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="us-gaap_FairValueMeasurementFrequencyDomain"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember" xlink:label="us-gaap_FairValueMeasurementsRecurringMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_FairValueByMeasurementFrequencyAxis" xlink:to="us-gaap_FairValueMeasurementFrequencyDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueMeasurementFrequencyDomain" xlink:to="us-gaap_FairValueMeasurementsRecurringMember" order="1"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails" xlink:title="06071 - Disclosure - Fair Value Measurements (Details 1)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfCashAndCashEquivalentsTable" xlink:label="us-gaap_ScheduleOfCashAndCashEquivalentsTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="us-gaap_FairValueByAssetClassAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_ScheduleOfCashAndCashEquivalentsTable" xlink:to="us-gaap_FairValueByAssetClassAxis" order="2"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails" xlink:title="06071 - Disclosure - Fair Value Measurements (Details 1)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="us-gaap_FairValueByAssetClassAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_MoneyMarketFundsMember" xlink:label="us-gaap_MoneyMarketFundsMember"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="us-gaap_USTreasurySecuritiesMember"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CertificatesOfDepositMember" xlink:label="us-gaap_CertificatesOfDepositMember"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ForwardContractsMember" xlink:label="us-gaap_ForwardContractsMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_CommonStockInvestmentsMember" xlink:label="opk_CommonStockInvestmentsMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BzneNoteAndBeneficialConversationFeatureMember" xlink:label="opk_BzneNoteAndBeneficialConversationFeatureMember"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StockOptionsMember" xlink:label="us-gaap_StockOptionsMember"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_WarrantMember" xlink:label="us-gaap_WarrantMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_FairValueByAssetClassAxis" xlink:to="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:to="us-gaap_MoneyMarketFundsMember" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:to="us-gaap_USTreasurySecuritiesMember" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:to="us-gaap_CertificatesOfDepositMember" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:to="us-gaap_ForwardContractsMember" order="4"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:to="opk_CommonStockInvestmentsMember" order="5"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:to="opk_BzneNoteAndBeneficialConversationFeatureMember" order="6"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:to="us-gaap_StockOptionsMember" order="7"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:to="us-gaap_WarrantMember" order="8"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails" xlink:title="06071 - Disclosure - Fair Value Measurements (Details 1)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfCashAndCashEquivalentsTable" xlink:label="us-gaap_ScheduleOfCashAndCashEquivalentsTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueByLiabilityClassAxis" xlink:label="us-gaap_FairValueByLiabilityClassAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_ScheduleOfCashAndCashEquivalentsTable" xlink:to="us-gaap_FairValueByLiabilityClassAxis" order="3"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails" xlink:title="06071 - Disclosure - Fair Value Measurements (Details 1)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueByLiabilityClassAxis" xlink:label="us-gaap_FairValueByLiabilityClassAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:label="us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_DeferredAcquisitionPaymentsNetOfDiscountMember" xlink:label="opk_DeferredAcquisitionPaymentsNetOfDiscountMember"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ContingentConsiderationClassifiedAsEquityMember" xlink:label="us-gaap_ContingentConsiderationClassifiedAsEquityMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_OpkoContigentConsiderationMember" xlink:label="opk_OpkoContigentConsiderationMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_FinetechContingentConsiderationMember" xlink:label="opk_FinetechContingentConsiderationMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_FarmadietContingentConsiderationMember" xlink:label="opk_FarmadietContingentConsiderationMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_FairValueByLiabilityClassAxis" xlink:to="us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:to="opk_DeferredAcquisitionPaymentsNetOfDiscountMember" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:to="us-gaap_ContingentConsiderationClassifiedAsEquityMember" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:to="opk_OpkoContigentConsiderationMember" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:to="opk_FinetechContingentConsiderationMember" order="4"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:to="opk_FarmadietContingentConsiderationMember" order="5"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails" xlink:title="06071 - Disclosure - Fair Value Measurements (Details 1)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfCashAndCashEquivalentsTable" xlink:label="us-gaap_ScheduleOfCashAndCashEquivalentsTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_ScheduleOfCashAndCashEquivalentsTable" xlink:to="us-gaap_FairValueByFairValueHierarchyLevelAxis" order="4"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails" xlink:title="06071 - Disclosure - Fair Value Measurements (Details 1)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="us-gaap_FairValueInputsLevel1Member"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="us-gaap_FairValueInputsLevel2Member"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="us-gaap_FairValueInputsLevel3Member"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:to="us-gaap_FairValueMeasurementsFairValueHierarchyDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:to="us-gaap_FairValueInputsLevel1Member" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:to="us-gaap_FairValueInputsLevel2Member" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:to="us-gaap_FairValueInputsLevel3Member" order="3"/>
</link:definitionLink>
<!-- Hypercube Definition (All) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails" xlink:title="06071 - Disclosure - Fair Value Measurements (Details 1)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfCashAndCashEquivalentsTable" xlink:label="us-gaap_ScheduleOfCashAndCashEquivalentsTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CashAndCashEquivalentsLineItems" xlink:label="us-gaap_CashAndCashEquivalentsLineItems"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_CashAndCashEquivalentsLineItems" xlink:to="us-gaap_ScheduleOfCashAndCashEquivalentsTable" order="5" xbrldt:closed="true" xbrldt:contextElement="segment"/>
</link:definitionLink>
<!-- Inheritance for Line Items: us-gaap:CashAndCashEquivalentsLineItems -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails" xlink:title="06071 - Disclosure - Fair Value Measurements (Details 1)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CashAndCashEquivalentsLineItems" xlink:label="us-gaap_CashAndCashEquivalentsLineItems"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_FinancialInstrumentsFinancialAssetsAndLiabilitiesBalanceSheetGroupingsAbstract" xlink:label="opk_FinancialInstrumentsFinancialAssetsAndLiabilitiesBalanceSheetGroupingsAbstract"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract" xlink:label="us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AssetsFairValueDisclosure" xlink:label="us-gaap_AssetsFairValueDisclosure"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosureAbstract" xlink:label="us-gaap_LiabilitiesFairValueDisclosureAbstract"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosure" xlink:label="us-gaap_LiabilitiesFairValueDisclosure"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_CashAndCashEquivalentsLineItems" xlink:to="us-gaap_AssetsFairValueDisclosure" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_CashAndCashEquivalentsLineItems" xlink:to="us-gaap_LiabilitiesFairValueDisclosure" order="5"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails" xlink:title="06071 - Disclosure - Fair Value Measurements (Details 1)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="us-gaap_FairValueByMeasurementFrequencyAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="us-gaap_FairValueMeasurementFrequencyDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_FairValueByMeasurementFrequencyAxis" xlink:to="us-gaap_FairValueMeasurementFrequencyDomain" order="1"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails" xlink:title="06071 - Disclosure - Fair Value Measurements (Details 1)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="us-gaap_FairValueByAssetClassAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_FairValueByAssetClassAxis" xlink:to="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" order="2"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails" xlink:title="06071 - Disclosure - Fair Value Measurements (Details 1)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueByLiabilityClassAxis" xlink:label="us-gaap_FairValueByLiabilityClassAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:label="us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_FairValueByLiabilityClassAxis" xlink:to="us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" order="3"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails" xlink:title="06071 - Disclosure - Fair Value Measurements (Details 1)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:to="us-gaap_FairValueMeasurementsFairValueHierarchyDomain" order="4"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails2" xlink:title="06072 - Disclosure - Fair Value Measurements (Details 2)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueByBalanceSheetGroupingTable" xlink:label="us-gaap_FairValueByBalanceSheetGroupingTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ContingentConsiderationByTypeAxis" xlink:label="us-gaap_ContingentConsiderationByTypeAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_FairValueByBalanceSheetGroupingTable" xlink:to="us-gaap_ContingentConsiderationByTypeAxis" order="1"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails2" xlink:title="06072 - Disclosure - Fair Value Measurements (Details 2)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ContingentConsiderationByTypeAxis" xlink:label="us-gaap_ContingentConsiderationByTypeAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ContingentConsiderationTypeDomain" xlink:label="us-gaap_ContingentConsiderationTypeDomain"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_ContingentConsiderationMember" xlink:label="opk_ContingentConsiderationMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_DeferredAcquisitionPaymentsNetOfDiscountMember" xlink:label="opk_DeferredAcquisitionPaymentsNetOfDiscountMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_ContingentConsiderationByTypeAxis" xlink:to="us-gaap_ContingentConsiderationTypeDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ContingentConsiderationTypeDomain" xlink:to="opk_ContingentConsiderationMember" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ContingentConsiderationTypeDomain" xlink:to="opk_DeferredAcquisitionPaymentsNetOfDiscountMember" order="2"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails2" xlink:title="06072 - Disclosure - Fair Value Measurements (Details 2)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueByBalanceSheetGroupingTable" xlink:label="us-gaap_FairValueByBalanceSheetGroupingTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="us-gaap_FairValueByAssetClassAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_FairValueByBalanceSheetGroupingTable" xlink:to="us-gaap_FairValueByAssetClassAxis" order="2"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails2" xlink:title="06072 - Disclosure - Fair Value Measurements (Details 2)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="us-gaap_FairValueByAssetClassAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BnzeNoteAndBnzeWarrantsMember" xlink:label="opk_BnzeNoteAndBnzeWarrantsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_FairValueByAssetClassAxis" xlink:to="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:to="opk_BnzeNoteAndBnzeWarrantsMember" order="1"/>
</link:definitionLink>
<!-- Hypercube Definition (All) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails2" xlink:title="06072 - Disclosure - Fair Value Measurements (Details 2)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueByBalanceSheetGroupingTable" xlink:label="us-gaap_FairValueByBalanceSheetGroupingTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems" xlink:label="us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems" xlink:to="us-gaap_FairValueByBalanceSheetGroupingTable" order="3" xbrldt:closed="true" xbrldt:contextElement="segment"/>
</link:definitionLink>
<!-- Inheritance for Line Items: us-gaap:FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails2" xlink:title="06072 - Disclosure - Fair Value Measurements (Details 2)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems" xlink:label="us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueAssumptionsAndMethodologyForAssetsAndLiabilitiesAbstract" xlink:label="us-gaap_FairValueAssumptionsAndMethodologyForAssetsAndLiabilitiesAbstract"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue" xlink:label="us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_AdditionsToReconciliationOfFairValueMeasurement" xlink:label="opk_AdditionsToReconciliationOfFairValueMeasurement"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisGainLossIncludedInEarningsAbstract" xlink:label="us-gaap_FairValueAssetsMeasuredOnRecurringBasisGainLossIncludedInEarningsAbstract"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetGainLossIncludedInEarnings1" xlink:label="us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetGainLossIncludedInEarnings1"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisGainLossIncludedInOtherComprehensiveIncomeLoss" xlink:label="us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisGainLossIncludedInOtherComprehensiveIncomeLoss"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:label="us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_TransferOutToEquityMethodInvestment" xlink:label="opk_TransferOutToEquityMethodInvestment"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems" xlink:to="us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems" xlink:to="opk_AdditionsToReconciliationOfFairValueMeasurement" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems" xlink:to="us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetGainLossIncludedInEarnings1" order="5"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems" xlink:to="us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisGainLossIncludedInOtherComprehensiveIncomeLoss" order="6"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems" xlink:to="us-gaap_OtherComprehensiveIncomeLossNetOfTax" order="7"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems" xlink:to="opk_TransferOutToEquityMethodInvestment" order="8"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails2" xlink:title="06072 - Disclosure - Fair Value Measurements (Details 2)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ContingentConsiderationByTypeAxis" xlink:label="us-gaap_ContingentConsiderationByTypeAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ContingentConsiderationTypeDomain" xlink:label="us-gaap_ContingentConsiderationTypeDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_ContingentConsiderationByTypeAxis" xlink:to="us-gaap_ContingentConsiderationTypeDomain" order="1"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetails2" xlink:title="06072 - Disclosure - Fair Value Measurements (Details 2)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="us-gaap_FairValueByAssetClassAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_FairValueByAssetClassAxis" xlink:to="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" order="2"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetailsTextual" xlink:title="06073 - Disclosure - Fair Value Measurements (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfCashAndCashEquivalentsTable" xlink:label="us-gaap_ScheduleOfCashAndCashEquivalentsTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="us-gaap_FairValueByAssetClassAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_ScheduleOfCashAndCashEquivalentsTable" xlink:to="us-gaap_FairValueByAssetClassAxis" order="1"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetailsTextual" xlink:title="06073 - Disclosure - Fair Value Measurements (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="us-gaap_FairValueByAssetClassAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="us-gaap_USTreasurySecuritiesMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_FairValueByAssetClassAxis" xlink:to="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:to="us-gaap_USTreasurySecuritiesMember" order="1"/>
</link:definitionLink>
<!-- Hypercube Definition (All) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetailsTextual" xlink:title="06073 - Disclosure - Fair Value Measurements (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfCashAndCashEquivalentsTable" xlink:label="us-gaap_ScheduleOfCashAndCashEquivalentsTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CashAndCashEquivalentsLineItems" xlink:label="us-gaap_CashAndCashEquivalentsLineItems"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_CashAndCashEquivalentsLineItems" xlink:to="us-gaap_ScheduleOfCashAndCashEquivalentsTable" order="2" xbrldt:closed="true" xbrldt:contextElement="segment"/>
</link:definitionLink>
<!-- Inheritance for Line Items: us-gaap:CashAndCashEquivalentsLineItems -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetailsTextual" xlink:title="06073 - Disclosure - Fair Value Measurements (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CashAndCashEquivalentsLineItems" xlink:label="us-gaap_CashAndCashEquivalentsLineItems"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_FairValueMeasurementsTextualAbstract" xlink:label="opk_FairValueMeasurementsTextualAbstract"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_MaturityDateOfSecurity" xlink:label="opk_MaturityDateOfSecurity"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_TreasuryStockValue" xlink:label="us-gaap_TreasuryStockValue"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionContingentConsiderationAtFairValue" xlink:label="us-gaap_BusinessAcquisitionContingentConsiderationAtFairValue"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccruedLiabilities" xlink:label="us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccruedLiabilities"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationOtherNoncurrentLiabilities" xlink:label="us-gaap_BusinessAcquisitionPurchasePriceAllocationOtherNoncurrentLiabilities"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_CashAndCashEquivalentsLineItems" xlink:to="opk_MaturityDateOfSecurity" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_CashAndCashEquivalentsLineItems" xlink:to="us-gaap_TreasuryStockValue" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_CashAndCashEquivalentsLineItems" xlink:to="us-gaap_BusinessAcquisitionContingentConsiderationAtFairValue" order="4"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_CashAndCashEquivalentsLineItems" xlink:to="us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesAccruedLiabilities" order="5"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_CashAndCashEquivalentsLineItems" xlink:to="us-gaap_BusinessAcquisitionPurchasePriceAllocationOtherNoncurrentLiabilities" order="6"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/FairValueMeasurementsDetailsTextual" xlink:title="06073 - Disclosure - Fair Value Measurements (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="us-gaap_FairValueByAssetClassAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_FairValueByAssetClassAxis" xlink:to="us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" order="1"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/DerivativeContractsDetails" xlink:title="0608 - Disclosure - Derivative Contracts (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable" xlink:label="us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="us-gaap_DerivativeInstrumentRiskAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable" xlink:to="us-gaap_DerivativeInstrumentRiskAxis" order="1"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/DerivativeContractsDetails" xlink:title="0608 - Disclosure - Derivative Contracts (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="us-gaap_DerivativeInstrumentRiskAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="us-gaap_DerivativeContractTypeDomain"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_ZeroToThirtyMember" xlink:label="opk_ZeroToThirtyMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_ThirtyOneToSixtyMember" xlink:label="opk_ThirtyOneToSixtyMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_SixtyOneToNinetyMember" xlink:label="opk_SixtyOneToNinetyMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_NinetyOneToOneHundredTwentyMember" xlink:label="opk_NinetyOneToOneHundredTwentyMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_OneHundredTwentyOneToOneHundredEightyMember" xlink:label="opk_OneHundredTwentyOneToOneHundredEightyMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_MoreThanOneHundredEightyMember" xlink:label="opk_MoreThanOneHundredEightyMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_DerivativeInstrumentRiskAxis" xlink:to="us-gaap_DerivativeContractTypeDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DerivativeContractTypeDomain" xlink:to="opk_ZeroToThirtyMember" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DerivativeContractTypeDomain" xlink:to="opk_ThirtyOneToSixtyMember" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DerivativeContractTypeDomain" xlink:to="opk_SixtyOneToNinetyMember" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DerivativeContractTypeDomain" xlink:to="opk_NinetyOneToOneHundredTwentyMember" order="4"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DerivativeContractTypeDomain" xlink:to="opk_OneHundredTwentyOneToOneHundredEightyMember" order="5"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DerivativeContractTypeDomain" xlink:to="opk_MoreThanOneHundredEightyMember" order="6"/>
</link:definitionLink>
<!-- Hypercube Definition (All) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/DerivativeContractsDetails" xlink:title="0608 - Disclosure - Derivative Contracts (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable" xlink:label="us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossLineItems" xlink:label="us-gaap_DerivativeInstrumentsGainLossLineItems"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_DerivativeInstrumentsGainLossLineItems" xlink:to="us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable" order="2" xbrldt:closed="true" xbrldt:contextElement="segment"/>
</link:definitionLink>
<!-- Inheritance for Line Items: us-gaap:DerivativeInstrumentsGainLossLineItems -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/DerivativeContractsDetails" xlink:title="0608 - Disclosure - Derivative Contracts (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossLineItems" xlink:label="us-gaap_DerivativeInstrumentsGainLossLineItems"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ForeignCurrencyDerivativesAbstract" xlink:label="us-gaap_ForeignCurrencyDerivativesAbstract"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_NotionalAmountOfForeignCurrencyDerivatives" xlink:label="us-gaap_NotionalAmountOfForeignCurrencyDerivatives"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ForeignCurrencyDerivativesAtFairValueNet" xlink:label="us-gaap_ForeignCurrencyDerivativesAtFairValueNet"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_EffectOfLossOnForeignCurrencyDerivativeBeforeTax" xlink:label="opk_EffectOfLossOnForeignCurrencyDerivativeBeforeTax"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DerivativeInstrumentsGainLossLineItems" xlink:to="us-gaap_NotionalAmountOfForeignCurrencyDerivatives" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DerivativeInstrumentsGainLossLineItems" xlink:to="us-gaap_ForeignCurrencyDerivativesAtFairValueNet" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_DerivativeInstrumentsGainLossLineItems" xlink:to="opk_EffectOfLossOnForeignCurrencyDerivativeBeforeTax" order="4"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/DerivativeContractsDetails" xlink:title="0608 - Disclosure - Derivative Contracts (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="us-gaap_DerivativeInstrumentRiskAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="us-gaap_DerivativeContractTypeDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_DerivativeInstrumentRiskAxis" xlink:to="us-gaap_DerivativeContractTypeDomain" order="1"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/RelatedPartyTransactionsDetails" xlink:title="0609 - Disclosure - Related Party Transactions (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:label="us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_RelatedPartyTransactionAxis" xlink:label="opk_RelatedPartyTransactionAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:to="opk_RelatedPartyTransactionAxis" order="1"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/RelatedPartyTransactionsDetails" xlink:title="0609 - Disclosure - Related Party Transactions (Details)">
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_RelatedPartyTransactionAxis" xlink:label="opk_RelatedPartyTransactionAxis"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_RelatedPartyTransactionDomain" xlink:label="opk_RelatedPartyTransactionDomain"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_ManagementOneMember" xlink:label="opk_ManagementOneMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_ManagementTwoMember" xlink:label="opk_ManagementTwoMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_ManagementFourMember" xlink:label="opk_ManagementFourMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_MrPregoNovoMember" xlink:label="opk_MrPregoNovoMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="opk_RelatedPartyTransactionAxis" xlink:to="opk_RelatedPartyTransactionDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="opk_RelatedPartyTransactionDomain" xlink:to="opk_ManagementOneMember" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="opk_RelatedPartyTransactionDomain" xlink:to="opk_ManagementTwoMember" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="opk_RelatedPartyTransactionDomain" xlink:to="opk_ManagementFourMember" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="opk_RelatedPartyTransactionDomain" xlink:to="opk_MrPregoNovoMember" order="4"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/RelatedPartyTransactionsDetails" xlink:title="0609 - Disclosure - Related Party Transactions (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:label="us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:to="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" order="2"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/RelatedPartyTransactionsDetails" xlink:title="0609 - Disclosure - Related Party Transactions (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="us-gaap_RelatedPartyDomain"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_TevaPharmaceuticalIndustriesMember" xlink:label="opk_TevaPharmaceuticalIndustriesMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_GammaTrustMember" xlink:label="opk_GammaTrustMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_HsuGammaMember" xlink:label="opk_HsuGammaMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_SorrentoMember" xlink:label="opk_SorrentoMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_GammaTrustAndHsuGammaMember" xlink:label="opk_GammaTrustAndHsuGammaMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_DrRichardLernerMember" xlink:label="opk_DrRichardLernerMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_TrsiMember" xlink:label="opk_TrsiMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_RealEstateHoldingsLlcMember" xlink:label="opk_RealEstateHoldingsLlcMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_ChromadexCorporationMember" xlink:label="opk_ChromadexCorporationMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BiozonePharmaceuticalsIncMember" xlink:label="opk_BiozonePharmaceuticalsIncMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_AeroPharmaceuticalsIncMember" xlink:label="opk_AeroPharmaceuticalsIncMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:to="us-gaap_RelatedPartyDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_TevaPharmaceuticalIndustriesMember" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_GammaTrustMember" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_HsuGammaMember" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_SorrentoMember" order="4"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_GammaTrustAndHsuGammaMember" order="5"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_DrRichardLernerMember" order="6"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_TrsiMember" order="7"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_RealEstateHoldingsLlcMember" order="8"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_ChromadexCorporationMember" order="9"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_BiozonePharmaceuticalsIncMember" order="10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="opk_AeroPharmaceuticalsIncMember" order="11"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/RelatedPartyTransactionsDetails" xlink:title="0609 - Disclosure - Related Party Transactions (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:label="us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_RelatedPartyAffliatesAxis" xlink:label="opk_RelatedPartyAffliatesAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:to="opk_RelatedPartyAffliatesAxis" order="3"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/RelatedPartyTransactionsDetails" xlink:title="0609 - Disclosure - Related Party Transactions (Details)">
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_RelatedPartyAffliatesAxis" xlink:label="opk_RelatedPartyAffliatesAxis"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_RelatedPartyAffliatesDomain" xlink:label="opk_RelatedPartyAffliatesDomain"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_FabrusIncMember" xlink:label="opk_FabrusIncMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_ManagementFiveMember" xlink:label="opk_ManagementFiveMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_ManagementSixMember" xlink:label="opk_ManagementSixMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_ManagementEightMember" xlink:label="opk_ManagementEightMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_ManagementSevenMember" xlink:label="opk_ManagementSevenMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="opk_RelatedPartyAffliatesAxis" xlink:to="opk_RelatedPartyAffliatesDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="opk_RelatedPartyAffliatesDomain" xlink:to="opk_FabrusIncMember" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="opk_RelatedPartyAffliatesDomain" xlink:to="opk_ManagementFiveMember" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="opk_RelatedPartyAffliatesDomain" xlink:to="opk_ManagementSixMember" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="opk_RelatedPartyAffliatesDomain" xlink:to="opk_ManagementEightMember" order="4"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="opk_RelatedPartyAffliatesDomain" xlink:to="opk_ManagementSevenMember" order="5"/>
</link:definitionLink>
<!-- Hypercube Definition (All) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/RelatedPartyTransactionsDetails" xlink:title="0609 - Disclosure - Related Party Transactions (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:label="us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RelatedPartyTransactionLineItems" xlink:label="us-gaap_RelatedPartyTransactionLineItems"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" order="4" xbrldt:closed="true" xbrldt:contextElement="segment"/>
</link:definitionLink>
<!-- Inheritance for Line Items: us-gaap:RelatedPartyTransactionLineItems -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/RelatedPartyTransactionsDetails" xlink:title="0609 - Disclosure - Related Party Transactions (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RelatedPartyTransactionLineItems" xlink:label="us-gaap_RelatedPartyTransactionLineItems"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_RelatedPartyTransactionsTextualAbstract" xlink:label="opk_RelatedPartyTransactionsTextualAbstract"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SalesRevenueNet" xlink:label="us-gaap_SalesRevenueNet"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_EquityMethodInvestments" xlink:label="us-gaap_EquityMethodInvestments"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_OwnershipPercentageHeldByMembers" xlink:label="opk_OwnershipPercentageHeldByMembers"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_OwnershipPercentageHeld" xlink:label="opk_OwnershipPercentageHeld"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuableParValue" xlink:label="opk_BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuableParValue"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_PromissoryNotesMaturityDate" xlink:label="opk_PromissoryNotesMaturityDate"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_WarrantsDuration" xlink:label="opk_WarrantsDuration"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_WarrantsToPurchaseCommonShares" xlink:label="opk_WarrantsToPurchaseCommonShares"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_ExercisePriceOfWarrantsAcquiredInEquityMethodInvestment" xlink:label="opk_ExercisePriceOfWarrantsAcquiredInEquityMethodInvestment"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="us-gaap_CommonStockSharesIssued"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:label="us-gaap_EquityMethodInvestmentOwnershipPercentage"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_MaximumOwnershipPercentageHeldByMembers" xlink:label="opk_MaximumOwnershipPercentageHeldByMembers"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:label="us-gaap_StockIssuedDuringPeriodValueNewIssues"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity" xlink:label="us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LineOfCreditFacilityPeriodicPaymentPrincipal" xlink:label="us-gaap_LineOfCreditFacilityPeriodicPaymentPrincipal"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LineOfCreditFacilityPeriodicPaymentInterest" xlink:label="us-gaap_LineOfCreditFacilityPeriodicPaymentInterest"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd" xlink:label="us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_FinancingForVariableInterestEntities" xlink:label="opk_FinancingForVariableInterestEntities"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_OwnershipPercentageHeldByDirector" xlink:label="opk_OwnershipPercentageHeldByDirector"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_AreaForMolecularDiagnosticsOperations" xlink:label="opk_AreaForMolecularDiagnosticsOperations"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_GrossRentIsForTwoYearTerm" xlink:label="opk_GrossRentIsForTwoYearTerm"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_TermOfUseOfSpaceToHouseMolecularDiagnosticsOperations" xlink:label="opk_TermOfUseOfSpaceToHouseMolecularDiagnosticsOperations"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_AdditionalTermOfUseOfSpaceToHouseMolecularDiagnosticsOperations" xlink:label="opk_AdditionalTermOfUseOfSpaceToHouseMolecularDiagnosticsOperations"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_LicensingFeesPreviouslyPaid" xlink:label="opk_LicensingFeesPreviouslyPaid"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_LicensingFeesPaid" xlink:label="opk_LicensingFeesPaid"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_ReimbursementOfCertainExpenses" xlink:label="opk_ReimbursementOfCertainExpenses"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_OutstandingCommonSharesAcquired" xlink:label="opk_OutstandingCommonSharesAcquired"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_LeaseSpaceInOfficeBuildingHavingPrincipalOffice" xlink:label="opk_LeaseSpaceInOfficeBuildingHavingPrincipalOffice"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_LeaseRentPerMonthForFirstYear" xlink:label="opk_LeaseRentPerMonthForFirstYear"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_LeaseRentPerMonthForFifthYear" xlink:label="opk_LeaseRentPerMonthForFifthYear"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_CreditForTenantImprovements" xlink:label="opk_CreditForTenantImprovements"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_VariableInterestEntityOwnershipPercentage" xlink:label="us-gaap_VariableInterestEntityOwnershipPercentage"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="us-gaap_SalesRevenueNet" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="us-gaap_EquityMethodInvestments" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_OwnershipPercentageHeldByMembers" order="4"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_OwnershipPercentageHeld" order="5"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_BusinessAcquisitionCostOfAcquiredEntityEquityInterestsIssuedAndIssuableParValue" order="6"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_PromissoryNotesMaturityDate" order="7"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_WarrantsDuration" order="8"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_WarrantsToPurchaseCommonShares" order="9"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_ExercisePriceOfWarrantsAcquiredInEquityMethodInvestment" order="10"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="us-gaap_CommonStockSharesIssued" order="11"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="us-gaap_EquityMethodInvestmentOwnershipPercentage" order="12"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_MaximumOwnershipPercentageHeldByMembers" order="13"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="us-gaap_StockIssuedDuringPeriodSharesNewIssues" order="14"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="us-gaap_StockIssuedDuringPeriodValueNewIssues" order="15"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity" order="16"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="us-gaap_LineOfCreditFacilityPeriodicPaymentPrincipal" order="17"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="us-gaap_LineOfCreditFacilityPeriodicPaymentInterest" order="18"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd" order="19"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_FinancingForVariableInterestEntities" order="20"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_OwnershipPercentageHeldByDirector" order="21"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_AreaForMolecularDiagnosticsOperations" order="22"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_GrossRentIsForTwoYearTerm" order="23"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_TermOfUseOfSpaceToHouseMolecularDiagnosticsOperations" order="24"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_AdditionalTermOfUseOfSpaceToHouseMolecularDiagnosticsOperations" order="25"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_LicensingFeesPreviouslyPaid" order="26"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_LicensingFeesPaid" order="27"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_ReimbursementOfCertainExpenses" order="28"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_OutstandingCommonSharesAcquired" order="29"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_LeaseSpaceInOfficeBuildingHavingPrincipalOffice" order="30"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_LeaseRentPerMonthForFirstYear" order="31"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_LeaseRentPerMonthForFifthYear" order="32"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="opk_CreditForTenantImprovements" order="33"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RelatedPartyTransactionLineItems" xlink:to="us-gaap_VariableInterestEntityOwnershipPercentage" order="34"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/RelatedPartyTransactionsDetails" xlink:title="0609 - Disclosure - Related Party Transactions (Details)">
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_RelatedPartyTransactionAxis" xlink:label="opk_RelatedPartyTransactionAxis"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_RelatedPartyTransactionDomain" xlink:label="opk_RelatedPartyTransactionDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="opk_RelatedPartyTransactionAxis" xlink:to="opk_RelatedPartyTransactionDomain" order="1"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/RelatedPartyTransactionsDetails" xlink:title="0609 - Disclosure - Related Party Transactions (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="us-gaap_RelatedPartyDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:to="us-gaap_RelatedPartyDomain" order="2"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/RelatedPartyTransactionsDetails" xlink:title="0609 - Disclosure - Related Party Transactions (Details)">
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_RelatedPartyAffliatesAxis" xlink:label="opk_RelatedPartyAffliatesAxis"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_RelatedPartyAffliatesDomain" xlink:label="opk_RelatedPartyAffliatesDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="opk_RelatedPartyAffliatesAxis" xlink:to="opk_RelatedPartyAffliatesDomain" order="3"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/CommitmentsAndContingenciesDetailsTextual" xlink:title="0610 - Disclosure - Commitments and Contingencies (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="us-gaap_BusinessAcquisitionAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:to="us-gaap_BusinessAcquisitionAxis" order="1"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/CommitmentsAndContingenciesDetailsTextual" xlink:title="0610 - Disclosure - Commitments and Contingencies (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="us-gaap_BusinessAcquisitionAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="us-gaap_BusinessAcquisitionAcquireeDomain"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_CurnaAcquisitionMember" xlink:label="opk_CurnaAcquisitionMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_BusinessAcquisitionAxis" xlink:to="us-gaap_BusinessAcquisitionAcquireeDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionAcquireeDomain" xlink:to="opk_CurnaAcquisitionMember" order="1"/>
</link:definitionLink>
<!-- Hypercube Definition (All) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/CommitmentsAndContingenciesDetailsTextual" xlink:title="0610 - Disclosure - Commitments and Contingencies (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="us-gaap_BusinessAcquisitionLineItems"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" order="2" xbrldt:closed="true" xbrldt:contextElement="segment"/>
</link:definitionLink>
<!-- Inheritance for Line Items: us-gaap:BusinessAcquisitionLineItems -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/CommitmentsAndContingenciesDetailsTextual" xlink:title="0610 - Disclosure - Commitments and Contingencies (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="us-gaap_BusinessAcquisitionLineItems"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionContingentConsiderationAtFairValue" xlink:label="us-gaap_BusinessAcquisitionContingentConsiderationAtFairValue"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionContingentConsiderationAtFairValue" order="1"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/CommitmentsAndContingenciesDetailsTextual" xlink:title="0610 - Disclosure - Commitments and Contingencies (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="us-gaap_BusinessAcquisitionAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="us-gaap_BusinessAcquisitionAcquireeDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_BusinessAcquisitionAxis" xlink:to="us-gaap_BusinessAcquisitionAcquireeDomain" order="1"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/SegmentsDetails" xlink:title="0611 - Disclosure - Segments (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable" xlink:label="us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StatementGeographicalAxis" xlink:label="us-gaap_StatementGeographicalAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable" xlink:to="us-gaap_StatementGeographicalAxis" order="1"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/SegmentsDetails" xlink:title="0611 - Disclosure - Segments (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StatementGeographicalAxis" xlink:label="us-gaap_StatementGeographicalAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="us-gaap_SegmentGeographicalDomain"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.sec.gov/country/2012/country-2012-01-31.xsd#country_US" xlink:label="country_US"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.sec.gov/country/2012/country-2012-01-31.xsd#country_CL" xlink:label="country_CL"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.sec.gov/country/2012/country-2012-01-31.xsd#country_ES" xlink:label="country_ES"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.sec.gov/country/2012/country-2012-01-31.xsd#country_IL" xlink:label="country_IL"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.sec.gov/country/2012/country-2012-01-31.xsd#country_MX" xlink:label="country_MX"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_StatementGeographicalAxis" xlink:to="us-gaap_SegmentGeographicalDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SegmentGeographicalDomain" xlink:to="country_US" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SegmentGeographicalDomain" xlink:to="country_CL" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SegmentGeographicalDomain" xlink:to="country_ES" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SegmentGeographicalDomain" xlink:to="country_IL" order="4"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SegmentGeographicalDomain" xlink:to="country_MX" order="5"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/SegmentsDetails" xlink:title="0611 - Disclosure - Segments (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable" xlink:label="us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="us-gaap_StatementBusinessSegmentsAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable" xlink:to="us-gaap_StatementBusinessSegmentsAxis" order="2"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/SegmentsDetails" xlink:title="0611 - Disclosure - Segments (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="us-gaap_StatementBusinessSegmentsAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SegmentDomain" xlink:label="us-gaap_SegmentDomain"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OperatingSegmentsMember" xlink:label="us-gaap_OperatingSegmentsMember"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CorporateMember" xlink:label="us-gaap_CorporateMember"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_DiscontinuedOperationsMember" xlink:label="opk_DiscontinuedOperationsMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_StatementBusinessSegmentsAxis" xlink:to="us-gaap_SegmentDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SegmentDomain" xlink:to="us-gaap_OperatingSegmentsMember" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SegmentDomain" xlink:to="us-gaap_CorporateMember" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_SegmentDomain" xlink:to="opk_DiscontinuedOperationsMember" order="3"/>
</link:definitionLink>
<!-- Hypercube Definition (All) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/SegmentsDetails" xlink:title="0611 - Disclosure - Segments (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable" xlink:label="us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems" xlink:label="us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems" xlink:to="us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable" order="3" xbrldt:closed="true" xbrldt:contextElement="segment"/>
</link:definitionLink>
<!-- Inheritance for Line Items: us-gaap:RevenuesFromExternalCustomersAndLongLivedAssetsLineItems -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/SegmentsDetails" xlink:title="0611 - Disclosure - Segments (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems" xlink:label="us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SalesRevenueServicesNetAbstract" xlink:label="us-gaap_SalesRevenueServicesNetAbstract"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:label="us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="us-gaap_DepreciationDepletionAndAmortization"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SalesRevenueGoodsNet" xlink:label="us-gaap_SalesRevenueGoodsNet"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_Assets" xlink:label="us-gaap_Assets"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems" xlink:to="us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems" xlink:to="us-gaap_DepreciationDepletionAndAmortization" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems" xlink:to="us-gaap_SalesRevenueGoodsNet" order="4"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems" xlink:to="us-gaap_Assets" order="5"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/SegmentsDetails" xlink:title="0611 - Disclosure - Segments (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StatementGeographicalAxis" xlink:label="us-gaap_StatementGeographicalAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="us-gaap_SegmentGeographicalDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_StatementGeographicalAxis" xlink:to="us-gaap_SegmentGeographicalDomain" order="1"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/SegmentsDetails" xlink:title="0611 - Disclosure - Segments (Details)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="us-gaap_StatementBusinessSegmentsAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SegmentDomain" xlink:label="us-gaap_SegmentDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_StatementBusinessSegmentsAxis" xlink:to="us-gaap_SegmentDomain" order="2"/>
</link:definitionLink>
<!-- Hypercube Definition (Line Items to Hypercube) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/SegmentsDetailsTextual" xlink:title="06111 - Disclosure - Segments (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable" xlink:label="us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_MajorCustomersAxis" xlink:label="us-gaap_MajorCustomersAxis"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable" xlink:to="us-gaap_MajorCustomersAxis" order="1"/>
</link:definitionLink>
<!-- Domain Members -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/SegmentsDetailsTextual" xlink:title="06111 - Disclosure - Segments (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_MajorCustomersAxis" xlink:label="us-gaap_MajorCustomersAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_NameOfMajorCustomerDomain" xlink:label="us-gaap_NameOfMajorCustomerDomain"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_CustomerOneMember" xlink:label="opk_CustomerOneMember"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_MajorCustomersAxis" xlink:to="us-gaap_NameOfMajorCustomerDomain" order="1"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_NameOfMajorCustomerDomain" xlink:to="opk_CustomerOneMember" order="1"/>
</link:definitionLink>
<!-- Hypercube Definition (All) -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/SegmentsDetailsTextual" xlink:title="06111 - Disclosure - Segments (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable" xlink:label="us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_EntityWideRevenueMajorCustomerLineItems" xlink:label="us-gaap_EntityWideRevenueMajorCustomerLineItems"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="us-gaap_EntityWideRevenueMajorCustomerLineItems" xlink:to="us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable" order="2" xbrldt:closed="true" xbrldt:contextElement="segment"/>
</link:definitionLink>
<!-- Inheritance for Line Items: us-gaap:EntityWideRevenueMajorCustomerLineItems -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/SegmentsDetailsTextual" xlink:title="06111 - Disclosure - Segments (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_EntityWideRevenueMajorCustomerLineItems" xlink:label="us-gaap_EntityWideRevenueMajorCustomerLineItems"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_SegmentsTextualAbstract" xlink:label="opk_SegmentsTextualAbstract"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_NumberOfReportableSegment" xlink:label="opk_NumberOfReportableSegment"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_NumberOfOperatingSegment" xlink:label="opk_NumberOfOperatingSegment"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_EntityWideRevenueMajorCustomerPercentage" xlink:label="us-gaap_EntityWideRevenueMajorCustomerPercentage"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_AccountsReceivableFromMajorCustomer" xlink:label="opk_AccountsReceivableFromMajorCustomer"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_NumberOfCustomerRepresentation" xlink:label="opk_NumberOfCustomerRepresentation"/>
<link:loc xlink:type="locator" xlink:href="opk-20120930.xsd#opk_PercentageOfCustomerInTotalRevenue" xlink:label="opk_PercentageOfCustomerInTotalRevenue"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_EntityWideRevenueMajorCustomerLineItems" xlink:to="opk_NumberOfReportableSegment" order="2"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_EntityWideRevenueMajorCustomerLineItems" xlink:to="opk_NumberOfOperatingSegment" order="3"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_EntityWideRevenueMajorCustomerLineItems" xlink:to="us-gaap_EntityWideRevenueMajorCustomerPercentage" order="4"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_EntityWideRevenueMajorCustomerLineItems" xlink:to="opk_AccountsReceivableFromMajorCustomer" order="5"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_EntityWideRevenueMajorCustomerLineItems" xlink:to="opk_NumberOfCustomerRepresentation" order="6"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_EntityWideRevenueMajorCustomerLineItems" xlink:to="opk_PercentageOfCustomerInTotalRevenue" order="7"/>
</link:definitionLink>
<!-- Dimension Defaults -->
<link:definitionLink xlink:type="extended" xlink:role="http://opko.com/role/SegmentsDetailsTextual" xlink:title="06111 - Disclosure - Segments (Details Textual)">
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_MajorCustomersAxis" xlink:label="us-gaap_MajorCustomersAxis"/>
<link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_NameOfMajorCustomerDomain" xlink:label="us-gaap_NameOfMajorCustomerDomain"/>
<link:definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_MajorCustomersAxis" xlink:to="us-gaap_NameOfMajorCustomerDomain" order="1"/>
</link:definitionLink>
</link:linkbase>

1 Subsequent Filing that References this Filing

  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 2/18/21  Opko Health, Inc.                 10-K       12/31/20  111:16M
↑Top
Filing Submission 0001193125-12-463415   –   Alternative Formats (Word / Rich Text, HTML, Plain Text, et al.)
Copyright © 2024 Fran Finnegan & Company LLC – All Rights Reserved.
About — Privacy — Redactions — Help — Thu., Apr. 25, 12:49:48.1pm ET