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Ziopharm Oncology Inc – ‘10-Q/A’ for 6/30/12 – ‘EX-101.SCH’

On:  Tuesday, 8/28/12, at 4:07pm ET   ·   For:  6/30/12   ·   Accession #:  1144204-12-48414   ·   File #:  1-33038

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  As Of               Filer                 Filing    For·On·As Docs:Size             Issuer                      Filing Agent

 8/28/12  Ziopharm Oncology Inc             10-Q/A      6/30/12   50:3.1M                                   Toppan Merrill/FA

Amendment to Quarterly Report   —   Form 10-Q   —   Sect. 13 / 15(d) – SEA’34
Filing Table of Contents

Document/Exhibit                   Description                      Pages   Size 

 1: 10-Q/A      Amendment to Quarterly Report                       HTML     29K 
 2: EX-31.1     Certification -- §302 - SOA'02                      HTML     20K 
 3: EX-31.2     Certification -- §302 - SOA'02                      HTML     20K 
 4: EX-32.1     Certification -- §906 - SOA'02                      HTML     18K 
32: R1          Document and Entity Information                     HTML     37K 
23: R2          Balance Sheets                                      HTML    112K 
30: R3          Balance Sheets (Parenthetical)                      HTML     39K 
34: R4          Statements Of Operations                            HTML     67K 
46: R5          Statement Of Stockholders' Equity                   HTML     66K 
24: R6          Statement Of Stockholders' Equity (Parenthetical)   HTML     18K 
29: R7          Statements of Cash Flows                            HTML    142K 
21: R8          Business                                            HTML     26K 
15: R9          Summary of Significant Accounting Policies          HTML     19K 
47: R10         Collaborations and Alliances                        HTML     21K 
36: R11         Fair Value Measurements                             HTML     38K 
35: R12         Net Loss per Share                                  HTML     23K 
40: R13         Related Party Transactions                          HTML     22K 
41: R14         Commitments and Contingencies                       HTML     53K 
39: R15         Warrants                                            HTML     52K 
42: R16         Common Stock                                        HTML     19K 
31: R17         Stock-Based Compensation                            HTML     48K 
33: R18         Fair Value Measurements (Tables)                    HTML     27K 
38: R19         Net Loss per Share (Tables)                         HTML     22K 
50: R20         Warrants (Tables)                                   HTML     42K 
44: R21         Stock-Based Compensation (Tables)                   HTML     52K 
26: R22         Business - Additional Information (Detail)          HTML     23K 
37: R23         Collaborations and Alliances - Additional           HTML     24K 
                Information (Detail)                                             
28: R24         Assets and Liabilities Measured at Fair Value on    HTML     26K 
                Recurring Basis (Detail)                                         
13: R25         Potential Dilutive Shares Excluded from             HTML     26K 
                Computation of Diluted Net Loss Per Share (Detail)               
45: R26         Related Party Transactions - Additional             HTML     28K 
                Information (Detail)                                             
48: R27         Commitments and Contingencies - Additional          HTML    121K 
                Information (Detail)                                             
18: R28         Number of Warrants Outstanding (Detail)             HTML     21K 
17: R29         Warrants - Additional Information (Detail)          HTML     74K 
19: R30         Assumptions Used In Binomial Valuation Model and    HTML     25K 
                Black-Scholes Valuation Model (Detail)                           
20: R31         Warrant Exercise (Detail)                           HTML     32K 
22: R32         Common Stock - Additional Information (Detail)      HTML     34K 
11: R33         Stock-Based Compensation Expense on All Employee    HTML     23K 
                and Non-Employee Awards (Detail)                                 
43: R34         Stock-Based Compensation - Additional Information   HTML     31K 
                (Detail)                                                         
25: R35         Fair Value of Stock Options Assumptions Using       HTML     34K 
                Black-Scholes Option Valuation Model (Detail)                    
27: R36         Stock Option Activity Under Stock Option Plan       HTML     83K 
                (Detail)                                                         
14: R37         Summary of Unvested Restricted Stock (Detail)       HTML     46K 
49: XML         IDEA XML File -- Filing Summary                      XML     74K 
16: EXCEL       IDEA Workbook of Financial Reports (.xls)            XLS    392K 
 5: EX-101.INS  XBRL Instance -- ziop-20120630                       XML    731K 
 7: EX-101.CAL  XBRL Calculations -- ziop-20120630_cal               XML    109K 
 8: EX-101.DEF  XBRL Definitions -- ziop-20120630_def                XML    650K 
 9: EX-101.LAB  XBRL Labels -- ziop-20120630_lab                     XML    966K 
10: EX-101.PRE  XBRL Presentations -- ziop-20120630_pre              XML    726K 
 6: EX-101.SCH  XBRL Schema -- ziop-20120630                         XSD    147K 
12: ZIP         XBRL Zipped Folder -- 0001144204-12-048414-xbrl      Zip    101K

‘EX-101.SCH’   —   XBRL Schema — ziop-20120630

This Exhibit is an XBRL XML File.

                                                                                                                                                                                
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<link:definition> 114 - Disclosure - Related Party Transactions </link:definition>
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<link:definition> 115 - Disclosure - Commitments and Contingencies </link:definition>
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<link:definition> 118 - Disclosure - Stock-Based Compensation </link:definition>
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<import namespace="http://xbrl.sec.gov/dei/2012-01-31" schemaLocation="http://xbrl.sec.gov/dei/2012/dei-2012-01-31.xsd"/>
<import namespace="http://xbrl.sec.gov/invest/2012-01-31" schemaLocation="http://xbrl.sec.gov/invest/2012/invest-2012-01-31.xsd"/>
<element name="AdditionalPaidInCapitalCommonStockMember" id="ziop_AdditionalPaidInCapitalCommonStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AdjustmentsToAdditionalPaidInCapitalWarrantExpired" id="ziop_AdjustmentsToAdditionalPaidInCapitalWarrantExpired" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="AssetAcquiredOtherThanThroughBusinessCombinationCashPaid" id="ziop_AssetAcquiredOtherThanThroughBusinessCombinationCashPaid" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BaxterHealthcareCorporationMember" id="ziop_BaxterHealthcareCorporationMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BeginningOfPeriodMember" id="ziop_BeginningOfPeriodMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="BlackScholesOptionPricingModelMember" id="ziop_BlackScholesOptionPricingModelMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ClassOfWarrantOrRightExercisedInPeriod" id="ziop_ClassOfWarrantOrRightExercisedInPeriod" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ClassOfWarrantOrRightExercisePeriod" id="ziop_ClassOfWarrantOrRightExercisePeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ClassOfWarrantOrRightExpiredInPeriod" id="ziop_ClassOfWarrantOrRightExpiredInPeriod" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ClassOfWarrantOrRightFairValueAssumptionExpectedDividendYield" id="ziop_ClassOfWarrantOrRightFairValueAssumptionExpectedDividendYield" type="num:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ClassOfWarrantOrRightFairValueAssumptionExpectedLife" id="ziop_ClassOfWarrantOrRightFairValueAssumptionExpectedLife" type="xbrli:decimalItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ClassOfWarrantOrRightFairValueAssumptionRiskFreeInterestRate" id="ziop_ClassOfWarrantOrRightFairValueAssumptionRiskFreeInterestRate" type="num:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ClassOfWarrantOrRightFairValueAssumptionStockVolatility" id="ziop_ClassOfWarrantOrRightFairValueAssumptionStockVolatility" type="num:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ClassOfWarrantOrRightIssuedInPeriod" id="ziop_ClassOfWarrantOrRightIssuedInPeriod" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ClassOfWarrantTerm" id="ziop_ClassOfWarrantTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CollaborationAgreementMember" id="ziop_CollaborationAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CollaborativeAgreementAxis" id="ziop_CollaborativeAgreementAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="CollaborativeAgreementDomain" id="ziop_CollaborativeAgreementDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CollaborativeArrangementAdditionalUpFrontPaymentToBeReceived" id="ziop_CollaborativeArrangementAdditionalUpFrontPaymentToBeReceived" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CollaborativeArrangementAgreementResearchFundingPeriod" id="ziop_CollaborativeArrangementAgreementResearchFundingPeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CommitmentAndContingenciesAxis" id="ziop_CommitmentAndContingenciesAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="CommitmentAndContingenciesDomain" id="ziop_CommitmentAndContingenciesDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CommitmentsAndContingenciesDisclosureLineItems" id="ziop_CommitmentsAndContingenciesDisclosureLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CommitmentsAndContingenciesDisclosureTable" id="ziop_CommitmentsAndContingenciesDisclosureTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem"/>
<element name="CommonStockDisclosureTextBlock" id="ziop_CommonStockDisclosureTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CommonStockIssuablePricePerShare" id="ziop_CommonStockIssuablePricePerShare" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CommonStockWarrantExercisePrice" id="ziop_CommonStockWarrantExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="CommonStockWarrantsFairValue" id="ziop_CommonStockWarrantsFairValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ConsultingFees" id="ziop_ConsultingFees" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ContractTerminationDescription" id="ziop_ContractTerminationDescription" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DEKKTecIncMember" id="ziop_DEKKTecIncMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DevelopmentMilestonePaymentsMember" id="ziop_DevelopmentMilestonePaymentsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DisclosureAssetsAndLiabilitiesMeasuredAtFairValueOnRecurringBasisAbstract" id="ziop_DisclosureAssetsAndLiabilitiesMeasuredAtFairValueOnRecurringBasisAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DisclosureAssumptionsUsedInBinomialValuationModelAndBlackScholesValuationModelAbstract" id="ziop_DisclosureAssumptionsUsedInBinomialValuationModelAndBlackScholesValuationModelAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DisclosureBusinessAdditionalInformationAbstract" id="ziop_DisclosureBusinessAdditionalInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DisclosureCollaborationsAndAlliancesAdditionalInformationAbstract" id="ziop_DisclosureCollaborationsAndAlliancesAdditionalInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DisclosureCommitmentsAndContingenciesAdditionalInformationAbstract" id="ziop_DisclosureCommitmentsAndContingenciesAdditionalInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DisclosureCommonStockAdditionalInformationAbstract" id="ziop_DisclosureCommonStockAdditionalInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DisclosureFairValueOfStockOptionsAssumptionsUsingBlackScholesOptionValuationModelAbstract" id="ziop_DisclosureFairValueOfStockOptionsAssumptionsUsingBlackScholesOptionValuationModelAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DisclosureNumberOfWarrantsOutstandingAbstract" id="ziop_DisclosureNumberOfWarrantsOutstandingAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DisclosurePotentialDilutiveSharesExcludedFromComputationOfDilutedNetLossPerShareAbstract" id="ziop_DisclosurePotentialDilutiveSharesExcludedFromComputationOfDilutedNetLossPerShareAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DisclosureRelatedPartyTransactionsAdditionalInformationAbstract" id="ziop_DisclosureRelatedPartyTransactionsAdditionalInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DisclosureStockBasedCompensationAdditionalInformationAbstract" id="ziop_DisclosureStockBasedCompensationAdditionalInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DisclosureStockBasedCompensationExpenseOnAllEmployeeAndNonEmployeeAwardsAbstract" id="ziop_DisclosureStockBasedCompensationExpenseOnAllEmployeeAndNonEmployeeAwardsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DisclosureStockOptionActivityUnderStockOptionPlanAbstract" id="ziop_DisclosureStockOptionActivityUnderStockOptionPlanAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DisclosureSummaryOfUnvestedRestrictedStockAbstract" id="ziop_DisclosureSummaryOfUnvestedRestrictedStockAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DisclosureWarrantExerciseAbstract" id="ziop_DisclosureWarrantExerciseAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DisclosureWarrantsAdditionalInformationAbstract" id="ziop_DisclosureWarrantsAdditionalInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="DocumentDocumentandEntityInformationAbstract" id="ziop_DocumentDocumentandEntityInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="EndOfPeriodMember" id="ziop_EndOfPeriodMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="EquityWarrantAssetMember" id="ziop_EquityWarrantAssetMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ExecutionOfSubscriptionAgreementMember" id="ziop_ExecutionOfSubscriptionAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisLineItems" id="ziop_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTable" id="ziop_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem"/>
<element name="GroupEightMember" id="ziop_GroupEightMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="GroupElevenMember" id="ziop_GroupElevenMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="GroupFiveMember" id="ziop_GroupFiveMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="GroupFourMember" id="ziop_GroupFourMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="GroupNineMember" id="ziop_GroupNineMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="GroupOneMember" id="ziop_GroupOneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="GroupSevenMember" id="ziop_GroupSevenMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="GroupSixMember" id="ziop_GroupSixMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="GroupTenMember" id="ziop_GroupTenMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="GroupThreeMember" id="ziop_GroupThreeMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="GroupTwoMember" id="ziop_GroupTwoMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="HarmonHillLlcMember" id="ziop_HarmonHillLlcMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="IntellectualPropertyRightsMember" id="ziop_IntellectualPropertyRightsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="IntrexonCorporationMember" id="ziop_IntrexonCorporationMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="InvestmentOptionExercisePeriod" id="ziop_InvestmentOptionExercisePeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="IssuanceOfWarrantsToPlacementAgentInPublicOffering" id="ziop_IssuanceOfWarrantsToPlacementAgentInPublicOffering" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="IssuanceOfWarrantsValue" id="ziop_IssuanceOfWarrantsValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="LiabilitiesMember" id="ziop_LiabilitiesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="MilestonePayment" id="ziop_MilestonePayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="MilestonePaymentsMaximumAmount" id="ziop_MilestonePaymentsMaximumAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="MonteCarloOptionPricingModelMember" id="ziop_MonteCarloOptionPricingModelMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="MonthlyPaymentMember" id="ziop_MonthlyPaymentMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NatureOfBusinessLineItems" id="ziop_NatureOfBusinessLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NatureOfBusinessTable" id="ziop_NatureOfBusinessTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem"/>
<element name="NonCashMember" id="ziop_NonCashMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NonVestedRestrictedStockMember" id="ziop_NonVestedRestrictedStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="NumberOfProducts" id="ziop_NumberOfProducts" type="xbrli:integerItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="OptionsToPurchaseCommonStock" id="ziop_OptionsToPurchaseCommonStock" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PercentageOfNetProfit" id="ziop_PercentageOfNetProfit" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PercentageOfRevenue" id="ziop_PercentageOfRevenue" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PeriodTypeAxis" id="ziop_PeriodTypeAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="PeriodTypeDomain" id="ziop_PeriodTypeDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PharmaceuticalResearchAssociatesIncMember" id="ziop_PharmaceuticalResearchAssociatesIncMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PhaseOneMember" id="ziop_PhaseOneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PhaseThreeMember" id="ziop_PhaseThreeMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PhaseTwoMember" id="ziop_PhaseTwoMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PPDDevelopmentLPMember" id="ziop_PPDDevelopmentLPMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ProceedsFromIssuanceOfCommonStockAndWarrantsNet" id="ziop_ProceedsFromIssuanceOfCommonStockAndWarrantsNet" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PublicOfferingMember" id="ziop_PublicOfferingMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="PublicOfferingNetPricePerShare" id="ziop_PublicOfferingNetPricePerShare" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="QuarterlyPaymentMember" id="ziop_QuarterlyPaymentMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ReclassificationOfWarrantLiabilitiesToEquity" id="ziop_ReclassificationOfWarrantLiabilitiesToEquity" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="RequirementOfEligibleFutureMilestonePaymentsAxis" id="ziop_RequirementOfEligibleFutureMilestonePaymentsAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="RequirementOfEligibleFutureMilestonePaymentsDomain" id="ziop_RequirementOfEligibleFutureMilestonePaymentsDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="RoyaltyPaymentsMember" id="ziop_RoyaltyPaymentsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SaleOfStockAxis" id="ziop_SaleOfStockAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/>
<element name="SaleOfStockDomain" id="ziop_SaleOfStockDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SalesEventsMilestoneMember" id="ziop_SalesEventsMilestoneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ScheduleOfResearchAndDevelopmentLineItems" id="ziop_ScheduleOfResearchAndDevelopmentLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ScheduleOfResearchAndDevelopmentTable" id="ziop_ScheduleOfResearchAndDevelopmentTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem"/>
<element name="ScheduleOfSecuritiesValuationAssumptionsTableTextBlock" id="ziop_ScheduleOfSecuritiesValuationAssumptionsTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ScheduleOfStockholdersEquityNoteWarrantsAndCommonStockActivityTableTextBlock" id="ziop_ScheduleOfStockholdersEquityNoteWarrantsAndCommonStockActivityTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsMethodUsedLineItems" id="ziop_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsMethodUsedLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsMethodUsedTable" id="ziop_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsMethodUsedTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem"/>
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsMethodUsedTableTextBlock" id="ziop_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsMethodUsedTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" id="ziop_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpectedToVestNumber" id="ziop_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpectedToVestNumber" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVested" id="ziop_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVested" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageExercisePriceAbstract" id="ziop_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageExercisePriceAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" id="ziop_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SolasiaPharmaKKMember" id="ziop_SolasiaPharmaKKMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="SouthernResearchInstituteMember" id="ziop_SouthernResearchInstituteMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="StockIssuedDuringPeriodSharesPublicOffering" id="ziop_StockIssuedDuringPeriodSharesPublicOffering" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="StockIssuedDuringPeriodSharesStockWarrantsExercised" id="ziop_StockIssuedDuringPeriodSharesStockWarrantsExercised" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="StockIssuedDuringPeriodValueStockWarrantsExercised" id="ziop_StockIssuedDuringPeriodValueStockWarrantsExercised" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="StockIssuedMember" id="ziop_StockIssuedMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TheUniversityOfTexasMDAndersonCancerCenterAndTheTexasAAndMUniversitySystemMember" id="ziop_TheUniversityOfTexasMDAndersonCancerCenterAndTheTexasAAndMUniversitySystemMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="TotalMember" id="ziop_TotalMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="UnderwriterMember" id="ziop_UnderwriterMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="UpFrontPaymentMember" id="ziop_UpFrontPaymentMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WarrantCashExerciseMember" id="ziop_WarrantCashExerciseMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WarrantExercisePrice" id="ziop_WarrantExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WarrantLiabilitiesFairValueDisclosure" id="ziop_WarrantLiabilitiesFairValueDisclosure" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WarrantLiabilityMember" id="ziop_WarrantLiabilityMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WarrantResetPrice" id="ziop_WarrantResetPrice" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WarrantsIssuedInInitialPublicOffering" id="ziop_WarrantsIssuedInInitialPublicOffering" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
<element name="WarrantsToPurchaseAggregateSharesOfCommonStock" id="ziop_WarrantsToPurchaseAggregateSharesOfCommonStock" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
</schema>

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